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Aliases for CRAMP1 Gene

Aliases for CRAMP1 Gene

  • Cramped Chromatin Regulator Homolog 1 2 3 4 5
  • Hematological And Neurological Expressed 1-Like Protein 3 4
  • CRAMP1L 3 4
  • HN1L 3 4
  • Crm, Cramped-Like (Drosophila) 2
  • Crm (Cramped Drosophila)-Like 2
  • T-Complex Expressed Gene 4 3
  • Protein Cramped-Like 3
  • Crm, Cramped-Like 3
  • C16orf34 4
  • KIAA1426 4
  • TCE4 3

External Ids for CRAMP1 Gene

Previous HGNC Symbols for CRAMP1 Gene


Summaries for CRAMP1 Gene

GeneCards Summary for CRAMP1 Gene

CRAMP1 (Cramped Chromatin Regulator Homolog 1) is a Protein Coding gene. An important paralog of this gene is ENSG00000261732.

Additional gene information for CRAMP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRAMP1 Gene

Genomics for CRAMP1 Gene

Regulatory Elements for CRAMP1 Gene

Enhancers for CRAMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001271 1.1 ENCODE 254.4 -340.5 -340499 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H001308 1.4 ENCODE dbSUPER 193 -301.6 -301571 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H002147 2 FANTOM5 Ensembl ENCODE dbSUPER 69.4 +543.5 543466 17.4 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 TBL3 UNKL E4F1 TSC2 SRRM2 ZNF213-AS1
GH16H000981 1.2 ENCODE dbSUPER 91.9 -630.9 -630850 0.2 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H002003 2 FANTOM5 Ensembl ENCODE dbSUPER 32.8 +394.9 394897 7.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 TBL3 CRAMP1 ZNF598 ENSG00000226890 ENSG00000255513 ENSG00000200059 AMDHD2 ENSG00000261240 ENSG00000260051 ENSG00000261505
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRAMP1 on UCSC Golden Path with GeneCards custom track

Promoters for CRAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279428 1075 4001 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766
ENSR00000082367 -1925 1201 HDGF PKNOX1 ARID4B SIN3A KLF7 ATF7 SP3 SP5 YY2 MXD4

Genomic Locations for CRAMP1 Gene

Genomic Locations for CRAMP1 Gene
65,584 bases
Plus strand

Genomic View for CRAMP1 Gene

Genes around CRAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRAMP1 Gene

Proteins for CRAMP1 Gene

  • Protein details for CRAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein cramped-like
    Protein Accession:
    Secondary Accessions:
    • A8MZL1
    • B1AJY1
    • Q8NDN1
    • Q9P2C1

    Protein attributes for CRAMP1 Gene

    1269 amino acids
    Molecular mass:
    134718 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAD38692.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for CRAMP1 Gene

Post-translational modifications for CRAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRAMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRAMP1 Gene

Domains & Families for CRAMP1 Gene

Gene Families for CRAMP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CRAMP1 Gene


Suggested Antigen Peptide Sequences for CRAMP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cramped family.
  • Belongs to the cramped family.
genes like me logo Genes that share domains with CRAMP1: view

Function for CRAMP1 Gene

Phenotypes From GWAS Catalog for CRAMP1 Gene

Gene Ontology (GO) - Molecular Function for CRAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with CRAMP1: view
genes like me logo Genes that share phenotypes with CRAMP1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRAMP1 Gene

Localization for CRAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRAMP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRAMP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with CRAMP1: view

Pathways & Interactions for CRAMP1 Gene

SuperPathways for CRAMP1 Gene

No Data Available

Interacting Proteins for CRAMP1 Gene

Gene Ontology (GO) - Biological Process for CRAMP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRAMP1 Gene

Drugs & Compounds for CRAMP1 Gene

No Compound Related Data Available

Transcripts for CRAMP1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRAMP1 Gene

No ASD Table

Relevant External Links for CRAMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CRAMP1 Gene:


Evidence on tissue expression from TISSUES for CRAMP1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CRAMP1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRAMP1 Gene

Orthologs for CRAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRAMP1L 33 34
  • 97.68 (n)
(Canis familiaris)
Mammalia CRAMP1L 33 34
  • 84.67 (n)
(Bos Taurus)
Mammalia CRAMP1L 33 34
  • 83.97 (n)
(Mus musculus)
Mammalia Cramp1l 33 16 34
  • 81.7 (n)
(Rattus norvegicus)
Mammalia Cramp1l 33
  • 81.63 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia CRAMP1L 34
  • 68 (a)
(Gallus gallus)
Aves CRAMP1L 33
  • 72.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cramp1l 33
  • 64.69 (n)
(Danio rerio)
Actinopterygii cramp1l 33
  • 63.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta crm 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea R151.8 34
  • 20 (a)
Species where no ortholog for CRAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRAMP1 Gene

Gene Tree for CRAMP1 (if available)
Gene Tree for CRAMP1 (if available)

Paralogs for CRAMP1 Gene

Paralogs for CRAMP1 Gene

genes like me logo Genes that share paralogs with CRAMP1: view

Variants for CRAMP1 Gene

Sequence variations from dbSNP and Humsavar for CRAMP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000028904 -- 1,630,700(+) TGGGA(C/T)AGCTC intron-variant
rs1000068095 -- 1,676,215(+) GCACC(C/T)ACCAC utr-variant-3-prime
rs1000105877 -- 1,634,500(+) TGGGG(C/G)GTCAC intron-variant
rs1000136617 -- 1,635,264(+) CTTGT(C/G)GCGTG intron-variant
rs1000163863 -- 1,632,043(+) GGTTC(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv833118 CNV loss 17160897
nsv827497 CNV gain 20364138
nsv827496 CNV gain 20364138
nsv518641 CNV loss 19592680
nsv428317 CNV gain 18775914
nsv1143803 CNV deletion 24896259
nsv1051692 CNV loss 25217958
esv3637621 CNV loss 21293372
esv3637620 CNV loss 21293372
esv2422427 CNV duplication 17116639
dgv4856n54 CNV loss 21841781
dgv4855n54 CNV loss 21841781

Variation tolerance for CRAMP1 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRAMP1 Gene

Disorders for CRAMP1 Gene

Relevant External Links for CRAMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRAMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRAMP1 Gene

Publications for CRAMP1 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for CRAMP1 Gene

Sources for CRAMP1 Gene

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