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Aliases for CRADD Gene

Aliases for CRADD Gene

  • CASP2 And RIPK1 Domain Containing Adaptor With Death Domain 2 3 5
  • RIP-Associated ICH1/CED3-Homologous Protein With Death Domain 2 3
  • RAIDD 3 4
  • RIP-Associated Protein With A Death Domain 4
  • Caspase And RIP Adaptor With Death Domain 3
  • Caspase And RIP Adapter With Death Domain 4
  • Death Domain Containing Protein CRADD 3
  • Death Adaptor Molecule RAIDD 3
  • MRT34 3

External Ids for CRADD Gene

Previous GeneCards Identifiers for CRADD Gene

  • GC12P093603
  • GC12P094592
  • GC12P094004
  • GC12P092573
  • GC12P092595
  • GC12P091137

Summaries for CRADD Gene

Entrez Gene Summary for CRADD Gene

  • This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CRADD Gene

CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include mental retardation, autosomal recessive 34 and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Gene Expression and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot for CRADD Gene

  • Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Gene Wiki entry for CRADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRADD Gene

Genomics for CRADD Gene

Regulatory Elements for CRADD Gene

Promoters for CRADD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRADD on UCSC Golden Path with GeneCards custom track

Genomic Location for CRADD Gene

Chromosome:
12
Start:
93,677,351 bp from pter
End:
93,894,840 bp from pter
Size:
217,490 bases
Orientation:
Plus strand

Genomic View for CRADD Gene

Genes around CRADD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRADD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRADD Gene

Proteins for CRADD Gene

  • Protein details for CRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78560-CRADD_HUMAN
    Recommended name:
    Death domain-containing protein CRADD
    Protein Accession:
    P78560
    Secondary Accessions:
    • B7Z2Q5

    Protein attributes for CRADD Gene

    Size:
    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts with PIDD.

    Three dimensional structures from OCA and Proteopedia for CRADD Gene

    Alternative splice isoforms for CRADD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRADD Gene

Proteomics data for CRADD Gene at MOPED

Post-translational modifications for CRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CRADD Gene

Domains & Families for CRADD Gene

Gene Families for CRADD Gene

Protein Domains for CRADD Gene

Graphical View of Domain Structure for InterPro Entry

P78560

UniProtKB/Swiss-Prot:

CRADD_HUMAN :
  • Contains a death domain involved in the binding of RIP protein.
Domain:
  • Contains a death domain involved in the binding of RIP protein.
  • The CARD domain mediates the interaction with caspase-2.
  • Contains 1 CARD domain.
  • Contains 1 death domain.
genes like me logo Genes that share domains with CRADD: view

Function for CRADD Gene

Molecular function for CRADD Gene

GENATLAS Biochemistry:
caspase 2 and RIPK2 adaptor containing with DEATH domain
UniProtKB/Swiss-Prot Function:
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Gene Ontology (GO) - Molecular Function for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030674 protein binding, bridging IPI 9044836
genes like me logo Genes that share ontologies with CRADD: view
genes like me logo Genes that share phenotypes with CRADD: view

Human Phenotype Ontology for CRADD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CRADD Gene

MGI Knock Outs for CRADD:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRADD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRADD Gene

Localization for CRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRADD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRADD Gene COMPARTMENTS Subcellular localization image for CRADD gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for CRADD Gene

Pathways & Interactions for CRADD Gene

genes like me logo Genes that share pathways with CRADD: view

Gene Ontology (GO) - Biological Process for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 21726810
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with CRADD: view

No data available for SIGNOR curated interactions for CRADD Gene

Drugs & Compounds for CRADD Gene

No Compound Related Data Available

Transcripts for CRADD Gene

Unigene Clusters for CRADD Gene

CASP2 and RIPK1 domain containing adaptor with death domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRADD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - -

Relevant External Links for CRADD Gene

GeneLoc Exon Structure for
CRADD
ECgene alternative splicing isoforms for
CRADD

Expression for CRADD Gene

mRNA expression in normal human tissues for CRADD Gene

Protein differential expression in normal tissues from HIPED for CRADD Gene

This gene is overexpressed in Rectum (11.9), Cardia (7.4), and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRADD Gene



SOURCE GeneReport for Unigene cluster for CRADD Gene Hs.591016

mRNA Expression by UniProt/SwissProt for CRADD Gene

P78560-CRADD_HUMAN
Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
genes like me logo Genes that share expression patterns with CRADD: view

Protein tissue co-expression partners for CRADD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRADD Gene

Orthologs for CRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRADD Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CRADD 35
  • 88.94 (n)
  • 87.94 (a)
CRADD 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cradd 35
  • 86.6 (n)
  • 89.95 (a)
Cradd 16
Cradd 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRADD 35
  • 99.83 (n)
  • 99.5 (a)
CRADD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRADD 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRADD 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRADD 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRADD 35
  • 69.54 (n)
  • 70.56 (a)
CRADD 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRADD 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489885 35
  • 59.39 (n)
  • 51.27 (a)
zebrafish
(Danio rerio)
Actinopterygii cradd 35
  • 57.22 (n)
  • 48.45 (a)
cradd 36
  • 47 (a)
OneToOne
Species with no ortholog for CRADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRADD Gene

ENSEMBL:
Gene Tree for CRADD (if available)
TreeFam:
Gene Tree for CRADD (if available)

Paralogs for CRADD Gene

(1) SIMAP similar genes for CRADD Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CRADD Gene

genes like me logo Genes that share paralogs with CRADD: view

No data available for Paralogs for CRADD Gene

Variants for CRADD Gene

Sequence variations from dbSNP and Humsavar for CRADD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_067536 Mental retardation, autosomal recessive 34 (MRT34)
rs1585 -- 93,760,349(+) AAACA(C/T)CAGCC intron-variant
rs183202 -- 93,806,581(+) TGCAT(C/G)TGCAC intron-variant
rs187890 -- 93,820,506(-) agtgg(C/T)atgat intron-variant
rs189719 -- 93,806,447(+) actcc(A/T)tctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRADD Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv825 CNV Insertion 18451855
nsv899440 CNV Gain 21882294
nsv510310 CNV Loss 20534489
nsv826 CNV Loss 18451855
esv2661164 CNV Deletion 23128226
esv2671632 CNV Deletion 23128226
nsv442284 CNV CNV 18776908
nsv826492 CNV Loss 20364138
nsv523282 CNV Loss 19592680
nsv9000 CNV Gain 18304495
nsv529049 CNV Loss 19592680
nsv524248 CNV Loss 19592680
nsv525412 CNV Loss 19592680

Variation tolerance for CRADD Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRADD Gene

HapMap Linkage Disequilibrium report
CRADD
Human Gene Mutation Database (HGMD)
CRADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRADD Gene

Disorders for CRADD Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRADD Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 34
  • mrt34
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search CRADD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRADD_HUMAN
  • Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. {ECO:0000269 PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRADD

Genetic Association Database (GAD)
CRADD
Human Genome Epidemiology (HuGE) Navigator
CRADD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRADD
genes like me logo Genes that share disorders with CRADD: view

No data available for Genatlas for CRADD Gene

Publications for CRADD Gene

  1. RAIDD is a new 'death' adaptor molecule. (PMID: 8985253) Duan H. … Dixit V.M. (Nature 1997) 2 3 4 67
  2. Purification, crystallization and preliminary x-ray crystallographic studies of RAIDD Death-Domain (DD). (PMID: 19582216) Jang T.H. … Park H.H. (Int J Mol Sci 2009) 3 23
  3. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H. … Zhivotovsky B. (Oncogene 2006) 3 23
  4. RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons. (PMID: 14765136) Jabado O. … Stefanis L. (Cell Death Differ. 2004) 3 23
  5. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. (PMID: 11832478) Guo Y. … Alnemri E.S. (J. Biol. Chem. 2002) 3 23

Products for CRADD Gene

Sources for CRADD Gene

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