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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRADD Gene

protein-coding GIFtS: 62
GCID: GC12P094004

CASP2 and RIPK1 domain containing adaptor with death domain

Explore 6 diseases affiliated with
CRADD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain¹ ²		Death Adaptor Molecule RAIDD²
RAIDD¹ ² ³ ⁵		Death Domain-Containing Protein CRADD²
RIP-Associated Protein With A Death Domain² ³		RIP-Associated ICH1/CED3-Homologous Protein With Death Domain²
MRT34²		Caspase And RIP Adapter With Death Domain³
Caspase And RIP Adaptor With Death Domain²

External Ids:	HGNC: 2340¹	Entrez Gene: 8738²	Ensembl: ENSG00000169372⁷	OMIM: 603454⁵	UniProtKB: P78560³

Export aliases for CRADD gene to outside databases

Previous GC identifers: GC12P093603 GC12P094592 GC12P092573 GC12P092595 GC12P091137

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRADD:

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell

apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death

signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of

other CARD domain-containing proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560

Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the

presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Gene Wiki entry for CRADD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRADD gene promoter:
SRF STAT1 SRF (504 AA) FOXD1 STAT1alpha Gfi-1 STAT2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRADD promoter sequence

Search SABiosciences Chromatin IP Primers for CRADD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRADD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.33-q23.1 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q21.33-q23.1

CRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRADD gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P094004: view genomic region (about GC identifiers)

Start:	94,071,151 bp from pter	End:	94,288,616 bp from pter
Size:	217,466 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560 (See protein sequence)

Recommended Name: Death domain-containing protein CRADD

Size: 199 amino acids; 22745 Da

Subunit: Interacts with PIDD

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

3 PDB 3D structures from and Proteopedia for CRADD:

2O71 (3D)

2OF5 (3D)

3CRD (3D)

Explore the universe of human proteins at neXtProt for CRADD: NX_P78560

CRADD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003796.1

ENSEMBL proteins:

ENSP00000449570 ENSP00000327647 ENSP00000449664 ENSP00000448685 ENSP00000448425

ENSP00000439068 ENSP00000442624

Human Recombinant Protein Products:

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	Novus Biologicals CRADD Proteins Novus Biologicals CRADD Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CRADD
	Uscn Proteins for CRADD

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

CRADD for ontologies About GeneDecksing

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	ThermoFisher Antibodies for CRADD

Assay Products for CRADD:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRADD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRADD for domains About GeneDecksing

3 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR000488 Death_domain

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry P78560

ProtoNet protein and cluster: P78560

2 Blocks protein families:

IPB000488 Death domain

IPB001315 CARD interaction domain

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560

Domain: Contains a death domain involved in the binding of RIP protein

Domain: The CARD domain mediates the interaction with caspase-2

Similarity: Contains 1 CARD domain

Similarity: Contains 1 death domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560

Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the

presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Genatlas biochemistry entry for CRADD:

caspase 2 and RIPK2 adaptor containing with DEATH domain

miRNA Products:		OriGene 3'-UTR Clone: CRADD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRADD
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRADD:
		hsa-miR-548am hsa-miR-548x
		SwitchGear 3'UTR luciferase reporter plasmid: CRADD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRADD (see all 7) OriGene shRNA RFP: CRADD OriGene siRNA: CRADD
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CRADD

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		GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRADD
		Search LifeMap BioReagents cell lines for CRADD

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CRADD

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	9044836
GO:0005515	protein binding	IPI	--
GO:0030674	protein binding, bridging	IPI	9044836
GO:0070513	death domain binding	IPI	9044836

CRADD for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CRADD:

Decreased influenza A virus in

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Cradd^tm1Mak for CRADD
3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cradd):

cellular

homeostasis/metabolism

mortality/aging

CRADD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

TNFR1 Pathway	0.53	TNF Signaling	0.40
HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptosis through Death Receptors	0.32
Apoptosis and survival TNFR1 signaling pathway	0.40	Fas Signaling	0.29
Apoptosis and survival_TNFR1 signaling pathway	0.40

Apoptosis and survival_Caspase cascade

Apoptosis and survival_Caspase cascade	1.00	Apoptosis and survival FAS signaling cascades	0.44
Apoptosis and survival Caspase cascade	1.00	Caspase cascade in apoptosis	0.42
Apoptosis and survival_FAS signaling cascades	0.44

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival_Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival Apoptotic TNF-family pathways	1.00

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Apoptosis

0.38

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CRADD

	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for CRADD

Apoptosis Signaling Pathways

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRADD

	Caspase Cascade
	TNF Signaling
	Apoptosis through Death Receptors
	Fas Signaling
	TNFR1 Pathway

4 GeneGo (Thomson Reuters) Pathways for CRADD

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival TNFR1 signaling pathway

5/6 BioSystems Pathways for CRADD (see all 6)

	Apoptosis Modulation and Signaling
	Apoptosis
	TNF-alpha/NF-kB Signaling Pathway
	HIV-1 Nef- Negative effector of Fas and TNF-alpha
	Ceramide signaling pathway

CRADD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRADD

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/28 Interacting proteins for CRADD (P78560^{1, 2, 3} ENSP00000327647⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIDD	Q9HB75¹^,²^,³, ENSP00000337797⁴	EBI-520375,EBI-520427 MINT-4054932 MINT-4054980 I2D: score=4 STRING: ENSP00000337797
CASP2	P42575¹^,²^,³, ENSP00000312664⁴	EBI-520375,EBI-520342 MINT-17424 I2D: score=6 STRING: ENSP00000312664
CASP8	Q14790³, ENSP00000351273⁴	I2D: score=2 STRING: ENSP00000351273
RIPK1	Q13546³, ENSP00000259808⁴	I2D: score=3 STRING: ENSP00000259808
TNFRSF1A	P19438³, ENSP00000162749⁴	I2D: score=1 STRING: ENSP00000162749

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	--	--
GO:0006917	induction of apoptosis	IDA	9044836
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP	--
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	TAS	9044836
GO:0042981	regulation of apoptotic process	--	--

CRADD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRADD
Search CenterWatch for drugs/clinical trials and news about CRADD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRADD gene:

NM_003805.3

Unigene Cluster for CRADD:

CASP2 and RIPK1 domain containing adaptor with death domain

Hs.591016 [show with all ESTs]

Unigene Representative Sequence: BC037905

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000552983 ENST00000549615 ENST00000332896(uc001tda.3) ENST00000552033

ENST00000548483 ENST00000551065(uc010sur.1 uc010sus.1) ENST00000542893

ENST00000547383 ENST00000550030 ENST00000548330 ENST00000541813

miRNA Products:		OriGene 3'-UTR Clone: CRADD Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRADD
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRADD:
		hsa-miR-548am hsa-miR-548x
		SwitchGear 3'UTR luciferase reporter plasmid: CRADD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRADD (see all 7) OriGene shRNA RFP: CRADD OriGene siRNA: CRADD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRADD

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRADD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRADD OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRADD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRADD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRADD

Additional cDNA sequence:

AB451280.1 AB451412.1 AK296225.1 AK314861.1 BC017042.1 BC037905.1 BT009837.1 CR407643.1

U79115.1 U84388.1

8 DOTS entries:

DT.413754 DT.100754396 DT.100754397 DT.101959803 DT.121201070 DT.40128065 DT.100754395 DT.91949369

24/94 AceView cDNA sequences (see all 94):

AA811130 BU628435 AA150833 CD742906 CB321796 AA626776 AI422699 CR407643

BM127462 BM981491 CA306602 AI791547 AI418811 BF969862 CA429170 CK724931

BC017042 CD108947 CK906099 AW136381 AI203643 AA745641 CD370871 AA194018

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRADD (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:			-				-		-				-		-
SP2:			-				-		-		-		-		-		-		-
SP3:			-
SP4:							-		-		-		-		-		-		-
SP5:															-		-		-

ECgene alternative splicing isoforms for CRADD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRADD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CRADD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CRADD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRADD

SOURCE GeneReport for Unigene cluster: Hs.591016

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560

Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis,

liver, skeletal muscle, fetal liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including CRADD (see all 6):

Endothelial Cell Biology in human mouse rat

p53 Signaling Pathway in human mouse rat

TNF Ligands & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRADD Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRADD

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CRADD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRADD gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cradd^{1 , 5}	CASP2 and RIPK1 domain containing adaptor with death more^{1, 5}	86.6(n)¹ 89.95(a)¹		10 (49.26 cM)⁵ 12905¹ NM_009950.2¹ NP_034080.1¹ 95174746⁵
chicken (Gallus gallus)	Aves	CRADD¹	CASP2 and RIPK1 domain containing adaptor with death more	69.54(n) 70.56(a)		417900 NM_001030748.1 NP_001025919.1
lizard (Anolis carolinensis)	Reptilia	CRADD⁶	--	62(a)	1 ↔ 1	5(31393478-31394464)
zebrafish (Danio rerio)	Actinopterygii	cradd¹	CASP2 and RIPK1 domain containing adaptor with death more	57.22(n) 48.45(a)		450046 NM_001006066.1 NP_001006066.1

ENSEMBL Gene Tree for CRADD (if available)
TreeFam Gene Tree for CRADD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRADD gene

1 SIMAP similar gene for CRADD using alignment to 8 protein entries: CRADD_HUMAN (see all proteins):

CASP2

CRADD for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CRADD
PGOHUM00000237835

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74760197^1,2	C,	--	91136759(+)	`AATTGA/GTTTAA`	1	--	us2k¹		2		WA	120
rs77013149^1,2	F,	--	91137605(+)	`CTAGGG/ATGGCT`	1	--	us2k¹		1		WA	118
rs73357713^1,2	C,	--	91137763(+)	`CACAGG/TAAGCA`	1	--	us2k¹		1		WA	2
rs78568297^1,2		--	91137764(+)	`ACAGTA/TAGCAT`	1	--	us2k¹		0	--	--	--	--
rs79640029^1,2	F,	--	91138128(+)	`CCGCTC/TTCCCC`	1	--	int¹		1		WA	118
rs4581493^1,2	C,F,H	--	91139334(+)	`GTGCAG/AAGGTA`	2	/K /E	mis¹ ese³		9		NS EA NA	956
rs4514473^1,2	C,F,H	--	91139406(+)	`TTCAAG/AAAATC`	2	/K /E	mis¹ ese³		6		NS EA	984
rs17021462^1,2	C,	--	91141382(+)	`GTAGAG/AGTATA`	1	--	int¹		4		NA WA	260
rs11831175^1,2	C,H,	--	91141489(+)	`ggtttA/Gagcaa`	1	--	int¹		1		NA	6
rs114640494^1,2	C,F,	--	91141829(+)	`ATGGGA/CAAAAA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for CRADD (94071151 - 94288616 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRADD
1 CNV: 38274
Human Gene Mutation Database (HGMD): CRADD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRADD

DNA2.0 Custom Variant and Variant Library Synthesis for CRADD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CRADD for disorders About GeneDecksing

OMIM gene information: 603454 OMIM disorders: --

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560

Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34) [MIM:614499]. A

disorder characterized by significantly below average general intellectual functioning associated with impairments in

adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected

individuals have mildly delayed development and significantly impaired cognitive function, precluding independent

living and self-care. Speech is rudimentary, but articulate; autism is not present

6 diseases for CRADD: About MalaCards

hepatitis b alzheimer's disease prostate cancer hepatitis

prostatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: CRADD (3 documents)

Export disorders for CRADD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRADD gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with CRADD)

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RAIDD is a new 'death' adaptor molecule. (PubMed id 8985253)^{1, 2, 3} Duan H. and Dixit V.M. (1997)
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PubMed id 9044836)^{1, 2, 3} Ahmad M.... Alnemri E.S. (1997)
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)^{1, 2, 9} Vakifahmetoglu H.... Zhivotovsky B. (2006)
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PubMed id 9695946)^{1, 2, 9} Chou J.J.... Wagner G. (1998)
Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)^{1, 2} Puffenberger E.G....Strauss K.A. (2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)^{1, 2} Tinel A. and Tschopp J. (2004)
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. (PubMed id 10713730)^{1, 9} Shearwin-Whyatt L.M....Kumar S. (2000)
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. (PubMed id 11832478)^{1, 9} Guo Y....Alnemri E.S. (2002)
Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)¹ Toyoshima M....Grandori C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8738	HGNC: 2340	AceView: CRADD	Ensembl:ENSG00000169372	euGenes: HUgn8738
ECgene: CRADD	H-InvDB: CRADD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRADD	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CRADD	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CRADD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CRADD gene:
Search GeneIP for patents involving CRADD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CASP2 and RIPK1 domain containing adaptor with death domain

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