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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRADD Gene

protein-coding   GIFtS: 65
GCID: GC12P094004

CASP2 And RIPK1 Domain Containing Adaptor With Death Domain

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain1 2     Caspase And RIP Adaptor With Death Domain2
RAIDD2 3 5     Death Adaptor Molecule RAIDD2
RIP-Associated ICH1/CED3-Homologous Protein With Death Domain1 2     Death Domain-Containing Protein CRADD2
RIP-Associated Protein With A Death Domain2 3     Caspase And RIP Adapter With Death Domain3
MRT342     

External Ids:    HGNC: 23401   Entrez Gene: 87382   Ensembl: ENSG000001693727   OMIM: 6034545   UniProtKB: P785603   

Export aliases for CRADD gene to outside databases

Previous GC identifers: GC12P093603 GC12P094592 GC12P092573 GC12P092595 GC12P091137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRADD Gene:
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell
apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell
death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and
numbers of other CARD domain-containing proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRADD Gene: 
CRADD (CASP2 and RIPK1 domain containing adaptor with death domain) is a protein-coding gene. Diseases associated with CRADD include narcolepsy, and mental retardation, and among its related super-pathways are TNFR1 Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the
presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Gene Wiki entry for CRADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRADD gene promoter:
         SRF   STAT1   SRF (504 AA)   FOXD1   STAT1alpha   Gfi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRADD promoter sequence
   Search SABiosciences Chromatin IP Primers for CRADD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.33-q23.1   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21.33-q23.1

CRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRADD gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P094004:  view genomic region     (about GC identifiers)

Start:
94,071,151 bp from pter      End:
94,288,616 bp from pter
Size:
217,466 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560 (See protein sequence)
Recommended Name: Death domain-containing protein CRADD  
Size: 199 amino acids; 22745 Da
Subunit: Interacts with PIDD
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for CRADD:
2O71 (3D)        2OF5 (3D)        3CRD (3D)    

Explore the universe of human proteins at neXtProt for CRADD: NX_P78560

Explore proteomics data for CRADD at MOPED 

CRADD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CRADD Protein Expression

REFSEQ proteins: NP_003796.1  
ENSEMBL proteins: 
 ENSP00000449570   ENSP00000327647   ENSP00000449664   ENSP00000448685   ENSP00000448425  
 ENSP00000439068   ENSP00000442624  

Human Recombinant Protein Products for CRADD: 
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Novus Biologicals CRADD Proteins
Novus Biologicals CRADD Lysates
Sino Biological Recombinant Protein for CRADD
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for CRADD
Cloud-Clone Corp. Proteins for CRADD 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus ISS--
GO:0005737cytoplasm ISS--

CRADD for ontologies           About GeneDecksing



CRADD Antibody Products: 
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Abcam antibodies for CRADD
Cloud-Clone Corp. Antibodies for CRADD 
ThermoFisher Antibodies for CRADD
LSBio Antibodies in human, mouse, rat for CRADD 

Assay Products for CRADD: 
Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for CRADD
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CRADD 
Cloud-Clone Corp. CLIAs for CRADD


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR011029 DEATH-like_dom
 IPR000488 Death_domain
 IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry P78560

ProtoNet protein and cluster: P78560

2 Blocks protein domains:
IPB000488 Death domain
IPB001315 CARD interaction domain


UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Domain: Contains a death domain involved in the binding of RIP protein
Domain: The CARD domain mediates the interaction with caspase-2
Similarity: Contains 1 CARD domain
Similarity: Contains 1 death domain


CRADD for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CRADD_HUMAN, P78560
Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the
presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

     Genatlas biochemistry entry for CRADD:
caspase 2 and RIPK2 adaptor containing with DEATH domain

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002020protease binding IPI9044836
GO:0005515protein binding IPI11156409
GO:0030674protein binding, bridging IPI9044836
GO:0070513death domain binding IPI9044836
     
CRADD for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CRADD:
 Decreased influenza A virus in  Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cradd):
 cellular  homeostasis/metabolism  mortality/aging 

CRADD for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Craddtm1Mak for CRADD

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CRADD 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRADD

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRADD 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRADD 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRADD
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRADD:
hsa-miR-548am hsa-miR-548x
SwitchGear 3'UTR luciferase reporter plasmidCRADD 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for CRADD
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRADD

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CRADD
Sirion Biotech Customized adenovirus for overexpression of CRADD

Clone
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OriGene clones in human, mouse for CRADD (see all 7)
OriGene ORF clones in mouse, rat for CRADD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRADD
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD
Sirion Biotech Customized lentivirus for stable overexpression of CRADD 
                     Customized lentivirus expression plasmids for stable overexpression of CRADD 

Cell Line
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Search LifeMap BioReagents cell lines for CRADD
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRADD


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CRADD About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1TWEAK Pathway
TNFR1 Pathway0.56
HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
TNF Signaling0.55
Apoptosis through Death Receptors0.42
Apoptosis and survival TNFR1 signaling pathway0.52
Fas Signaling0.35
2Apoptosis and survival Caspase cascade
Apoptosis and survival FAS signaling cascades0.44
Caspase cascade in apoptosis0.42
Apoptosis and survival Caspase cascade0.44
3Apoptosis and survival Apoptotic TNF-family pathways
Apoptosis and survival Apoptotic TNF-family pathways0.35
Apoptosis Signaling Pathways0.35
4Apoptosis Modulation and Signaling
Apoptosis0.38
Apoptosis Modulation and Signaling0.38
5TNF Signaling
Death Receptor Signaling0.50

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 EMD Millipore Pathways for CRADD
    Apoptosis and survival TNFR1 signaling pathway
Apoptosis and survival Caspase cascade
Apoptosis and survival FAS signaling cascades
Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for CRADD
    Apoptosis Signaling Pathways

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRADD
    Caspase Cascade
TNF Signaling
Apoptosis through Death Receptors
Fas Signaling
TNFR1 Pathway

4 GeneGo (Thomson Reuters) Pathways for CRADD
    Apoptosis and survival Apoptotic TNF-family pathways
Apoptosis and survival Caspase cascade
Apoptosis and survival FAS signaling cascades
Apoptosis and survival TNFR1 signaling pathway

5/6 BioSystems Pathways for CRADD (see all 6)
    Apoptosis
Apoptosis Modulation and Signaling
TNF-alpha/NF-kB Signaling Pathway
HIV-1 Nef- Negative effector of Fas and TNF-alpha
Ceramide signaling pathway

1 Sino Biological Pathway for CRADD 
    Death Receptor Signaling



CRADD for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRADD

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/28 Interacting proteins for CRADD (P785601, 2, 3 ENSP000003276474) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
PIDDQ9HB751, 2, 3, ENSP000003377974EBI-520375,EBI-520427 MINT-4054932 MINT-4054980 I2D: score=4 STRING: ENSP00000337797
CASP2P425751, 2, 3, ENSP000003126644EBI-520375,EBI-520342 MINT-17424 I2D: score=6 STRING: ENSP00000312664
CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
RIPK1Q135463, ENSP000002598084I2D: score=3 STRING: ENSP00000259808
TNFRSF1AP194383, ENSP000001627494I2D: score=1 STRING: ENSP00000162749
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process ----
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP--
GO:0007165signal transduction ----
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IC9044836
GO:0042981regulation of apoptotic process IEA--

CRADD for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRADD

Search CenterWatch for drugs/clinical trials and news about CRADD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRADD gene: 
NM_003805.3  

Unigene Cluster for CRADD:

CASP2 and RIPK1 domain containing adaptor with death domain
Hs.591016  [show with all ESTs]
Unigene Representative Sequence: BC037905
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000552983 ENST00000549615 ENST00000332896(uc001tda.3) ENST00000552033
ENST00000548483 ENST00000551065(uc010sur.1 uc010sus.1) ENST00000542893
ENST00000547383 ENST00000550030 ENST00000548330 ENST00000541813

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRADD
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRADD:
hsa-miR-548am hsa-miR-548x
SwitchGear 3'UTR luciferase reporter plasmidCRADD 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CRADD
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRADD
Clone
Products:
     
OriGene clones in human, mouse for CRADD (see all 7)
OriGene ORF clones in mouse, rat for CRADD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRADD
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD
Sirion Biotech Customized lentivirus for stable overexpression of CRADD 
                     Customized lentivirus expression plasmids for stable overexpression of CRADD 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CRADD
OriGene qSTAR qPCR primer pairs in human, mouse for CRADD
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRADD
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRADD
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRADD

Additional mRNA sequence: 

AB451280.1 AB451412.1 AK296225.1 AK314861.1 BC017042.1 BC037905.1 BT009837.1 CR407643.1 
U79115.1 U84388.1 

8 DOTS entries:

DT.413754  DT.100754396  DT.100754397  DT.101959803  DT.121201070  DT.40128065  DT.100754395  DT.91949369 

24/94 AceView cDNA sequences (see all 94):

AA626776 CA306602 AA811130 BM127462 BM981491 AW136381 CR407643 CD108947 
AA902585 CD370871 CK724931 AI422699 NM_003805 BU628435 BC017042 CA307146 
AI418811 AI733057 AA745641 CK906099 AA194018 AI203643 CA429170 BF969862 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRADD (see all 8)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1:        -           -     -           -     -                                 
SP2:        -           -     -     -     -     -     -     -                     
SP3:        -                                                                     
SP4:                    -     -     -     -     -     -     -                     
SP5:                                            -     -     -                     


ECgene alternative splicing isoforms for CRADD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRADD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CRADD Expression
About this image


See CRADD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRADD

SOURCE GeneReport for Unigene cluster: Hs.591016

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart,
testis, liver, skeletal muscle, fetal liver and kidney

    SABiosciences Expression via Pathway-Focused PCR Arrays including CRADD (see all 6): 
          Endothelial Cell Biology in human mouse rat
          p53 Signaling Pathway in human mouse rat
          TNF Ligands & Receptors in human mouse rat
          Neurotoxicity in human mouse rat
          Apoptosis 384HT in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for CRADD
OriGene qSTAR qPCR primer pairs in human, mouse for CRADD
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRADD
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRADD
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRADD
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRADD

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRADD gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cradd1 , 5 CASP2 and RIPK1 domain containing adaptor with death more1, 5 86.6(n)1
89.95(a)1
  10 (49.26 cM)5
129051  NM_009950.21  NP_034080.11 
 951747465 
chicken
(Gallus gallus)
Aves CRADD1 CASP2 and RIPK1 domain containing adaptor with death more 69.54(n)
70.56(a)
  417900  NM_001030748.1  NP_001025919.1 
lizard
(Anolis carolinensis)
Reptilia CRADD6
Uncharacterized protein
60(a)
1 ↔ 1
5(31393478-31394464)
zebrafish
(Danio rerio)
Actinopterygii cradd1 CASP2 and RIPK1 domain containing adaptor with death more 57.22(n)
48.45(a)
  450046  NM_001006066.1  NP_001006066.1 


ENSEMBL Gene Tree for CRADD (if available)
TreeFam Gene Tree for CRADD (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CRADD gene
1 SIMAP similar gene for CRADD using alignment to 8 protein entries:     CRADD_HUMAN (see all proteins):
CASP2

CRADD for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CRADD
PGOHUM00000237835


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/3612 SNPs in CRADD are shown (see all 3612)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0675364
Mental retardation, autosomal recessive 34 (MRT34)4--see VAR_0675362 G R mis40--------
rs1506719151,2
C--91192797(+) CATTT-/TCAGTG
        
TCTCT
1 -- int10--------
rs178371631,2
F,H--91192799(+) TTTTCA/TGTGTC 1 -- int15Minor allele frequency- T:0.01NA NS 344
rs673707331,2
C--91192799(+) TTTTC-/AGTGTC
        
TCTAA
1 -- int10--------
rs1133579961,2
C--91192802(+) TCAGTG/TTCTCT 1 -- int10--------
rs79659921,2
C,A--91199352(+) AAGAGA/CGGGAG 1 -- int1 trp32Minor allele frequency- C:0.25NA WA 4
rs58001151,2
C--91225244(+) TTTGG-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00CSA 2
rs108595751,2
C,A--91230651(+) CCAGGC/TGGGAG 1 -- int10--------
rs108595761,2
A--91230652(+) CAGGTG/TGGAGT 1 -- int10--------
rs356253211,2
C--91250995(+) AACTA-/T/TAAC
        
AAGCA
1 -- int10--------

HapMap Linkage Disequilibrium report for CRADD (94071151 - 94288616 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/14 variations for CRADD (see all 14):    About this table     
Variant IDTypeSubtypePubMed ID
esv2671632CNV Deletion23128226
esv2661164CNV Deletion23128226
nsv825CNV Insertion18451855
nsv524248CNV Loss19592680
nsv523282CNV Loss19592680
nsv510310CNV Loss20534489
nsv529049CNV Loss19592680
nsv826CNV Loss18451855
nsv826492CNV Loss20364138
nsv525412CNV Loss19592680


Human Gene Mutation Database (HGMD): CRADD
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603454    OMIM disorders: --

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
  • Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptative behavior
    and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly
    delayed development and significantly impaired cognitive function, precluding independent living and self-care.
    Speech is rudimentary, but articulate; autism is not present. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 9 diseases for CRADD:    About MalaCards
    narcolepsy    mental retardation    hepatitis b    alzheimer's disease
    hepatitis    prostate cancer    prostatitis    endotheliitis
    neuronitis


    CRADD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CRADD
    Human Genome Epidemiology (HuGE) Navigator: CRADD (3 documents)

    Export disorders for CRADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRADD gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CRADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAIDD is a new 'death' adaptor molecule. (PubMed id 8985253)1, 2, 3 Duan H. and Dixit V.M. (1997)
    2. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PubMed id 9044836)1, 2, 3 Ahmad M.... Alnemri E.S. (1997)
    3. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)1, 2, 9 Vakifahmetoglu H.... Zhivotovsky B. (2006)
    4. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PubMed id 9695946)1, 2, 9 Chou J.J.... Wagner G. (1998)
    5. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)1, 2 Puffenberger E.G....Strauss K.A. (2012)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    7. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)1, 2 Tinel A. and Tschopp J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8738 HGNC: 2340 AceView: CRADD Ensembl:ENSG00000169372 euGenes: HUgn8738
    ECgene: CRADD H-InvDB: CRADD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRADD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRADD gene:
    Search GeneIP for patents involving CRADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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