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CRADD Gene

protein-coding   GIFtS: 64
GCID: GC12P094004

CASP2 And RIPK1 Domain Containing Adaptor With Death Domain

  See CRADD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain1 2     Caspase And RIP Adaptor With Death Domain2
RAIDD2 3 5     Death Adaptor Molecule RAIDD2
RIP-Associated ICH1/CED3-Homologous Protein With Death Domain1 2     Death Domain-Containing Protein CRADD2
RIP-Associated Protein With A Death Domain2 3     Caspase And RIP Adapter With Death Domain3
MRT342 5     

External Ids:    HGNC: 23401   Entrez Gene: 87382   Ensembl: ENSG000001693727   OMIM: 6034545   UniProtKB: P785603   

Export aliases for CRADD gene to outside databases

Previous GC identifers: GC12P093603 GC12P094592 GC12P092573 GC12P092595 GC12P091137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRADD Gene:
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell
apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell
death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and
numbers of other CARD domain-containing proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRADD Gene:
CRADD (CASP2 and RIPK1 domain containing adaptor with death domain) is a protein-coding gene. Diseases associated with CRADD include mental retardation, autosomal recessive 34, and mental retardation, autosomal recessive 43. GO annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the
presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Gene Wiki entry for CRADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRADD gene promoter:
         SRF   STAT1   SRF (504 AA)   FOXD1   STAT1alpha   Gfi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRADD promoter sequence
   Search Chromatin IP Primers for CRADD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.33-q23.1   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21.33-q23.1

CRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRADD gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P094004:  view genomic region     (about GC identifiers)

Start:
94,071,151 bp from pter      End:
94,288,616 bp from pter
Size:
217,466 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560 (See protein sequence)
Recommended Name: Death domain-containing protein CRADD  
Size: 199 amino acids; 22745 Da
Subunit: Interacts with PIDD
3 PDB 3D structures from and Proteopedia for CRADD:
2O71 (3D)        2OF5 (3D)        3CRD (3D)    

Explore the universe of human proteins at neXtProt for CRADD: NX_P78560

Explore proteomics data for CRADD at MOPED


See CRADD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003796.1  
ENSEMBL proteins: 
 ENSP00000449570   ENSP00000327647   ENSP00000449664   ENSP00000448685   ENSP00000448425  
 ENSP00000439068   ENSP00000442624  

CRADD Human Recombinant Protein Products:

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Novus Biologicals CRADD Proteins
Novus Biologicals CRADD Lysates
Sino Biological Recombinant Protein for CRADD
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Cloud-Clone Corp. Proteins for CRADD

 
Search eBioscience for Proteins for CRADD 

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ThermoFisher Antibodies for CRADD
LSBio Antibodies in human, mouse, rat for CRADD

CRADD Assay Products:

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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CRADD
Cloud-Clone Corp. CLIAs for CRADD
Search eBioscience for ELISAs for CRADD 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR011029 DEATH-like_dom
 IPR000488 Death_domain
 IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry P78560

ProtoNet protein and cluster: P78560

2 Blocks protein domains:
IPB000488 Death domain
IPB001315 CARD interaction domain


UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Domain: Contains a death domain involved in the binding of RIP protein
Domain: The CARD domain mediates the interaction with caspase-2
Similarity: Contains 1 CARD domain
Similarity: Contains 1 death domain


Find genes that share domains with CRADD           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CRADD_HUMAN, P78560
Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the
presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

     Genatlas biochemistry entry for CRADD:
caspase 2 and RIPK2 adaptor containing with DEATH domain

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002020protease binding IPI9044836
GO:0005515protein binding IPI11156409
GO:0030674protein binding, bridging IPI9044836
GO:0070513death domain binding IPI9044836
     
Find genes that share ontologies with CRADD           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for CRADD:
 Decreased influenza A virus in  Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cradd):
 cellular  homeostasis/metabolism  mortality/aging 

Find genes that share phenotypes with CRADD           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Craddtm1Mak for CRADD

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRADD
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRADD

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRADD
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRADD

miRNA
Products:
    
miRTarBase miRNAs that target CRADD:
hsa-mir-26b-5p (MIRT029087)

Block miRNA regulation of human, mouse, rat CRADD using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CRADD:
hsa-miR-548am hsa-miR-548x
SwitchGear 3'UTR luciferase reporter plasmidCRADD 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CRADD
Predesigned siRNA for gene silencing in human, mouse, rat CRADD

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CRADD

Clone
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OriGene clones in human, mouse for CRADD (see all 6)
OriGene ORF clones in mouse, rat for CRADD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRADD
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CRADD
Browse ESI BIO Cell Lines and PureStem Progenitors for CRADD 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRADD


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CRADD_HUMAN, P78560: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol3
cytoskeleton1
mitochondrion1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus ISS--
GO:0005737cytoplasm ISS--

Find genes that share ontologies with CRADD           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CRADD About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1TWEAK Pathway
TNFR1 Pathway0.56
HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
TNF Signaling0.55
Apoptosis through Death Receptors0.42
Apoptosis and survival TNFR1 signaling pathway0.52
Fas Signaling0.35
2Apoptosis and survival Caspase cascade
Apoptosis and survival Caspase cascade0.44
Caspase cascade in apoptosis0.42
Apoptosis and survival FAS signaling cascades0.44
3Apoptosis Signaling Pathways
Apoptosis and survival Apoptotic TNF family pathways0.35
Apoptosis Signaling Pathways0.35
4Apoptosis (WikiPathways)
Apoptosis0.38
Apoptosis Modulation and Signaling0.38
5TNF Signaling
Death Receptor Signaling0.50

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CRADD
    Apoptosis Signaling Pathways

5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRADD
    Caspase Cascade
TNF Signaling
Apoptosis through Death Receptors
Fas Signaling
TNFR1 Pathway

4 GeneGo (Thomson Reuters) Pathways for CRADD
    Apoptosis and survival Apoptotic TNF-family pathways
Apoptosis and survival Caspase cascade
Apoptosis and survival FAS signaling cascades
Apoptosis and survival TNFR1 signaling pathway

Selected BioSystems Pathways for CRADD (see all 6)
    Apoptosis
Apoptosis Modulation and Signaling
TNF-alpha/NF-kB Signaling Pathway
Caspase cascade in apoptosis
HIV-1 Nef- Negative effector of Fas and TNF-alpha

1 Sino Biological Pathway for CRADD
    Death Receptor Signaling


    Pathway & Disease-focused RT2 Profiler PCR Arrays including CRADD (see all 6): 
          Endothelial Cell Biology in human mouse rat
          p53 Signaling Pathway in human mouse rat
          TNF Ligands & Receptors in human mouse rat
          Neurotoxicity in human mouse rat
          Apoptosis 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CRADD

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for CRADD (P785601, 2, 3 ENSP000003276474) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
PIDDQ9HB751, 2, 3, ENSP000003377974EBI-520375,EBI-520427 MINT-4054932 MINT-4054980 I2D: score=4 STRING: ENSP00000337797
CASP2P425751, 2, 3, ENSP000003126644EBI-520375,EBI-520342 MINT-17424 I2D: score=6 STRING: ENSP00000312664
CASP8Q147903, ENSP000003512734I2D: score=2 STRING: ENSP00000351273
RIPK1Q135463, ENSP000002598084I2D: score=3 STRING: ENSP00000259808
TNFRSF1AP194383, ENSP000001627494I2D: score=1 STRING: ENSP00000162749
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP--
GO:0007165signal transduction ----
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IC9044836
GO:0042981regulation of apoptotic process ----

Find genes that share ontologies with CRADD           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CRADD



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CRADD gene: 
NM_003805.3  

Unigene Cluster for CRADD:

CASP2 and RIPK1 domain containing adaptor with death domain
Hs.591016  [show with all ESTs]
Unigene Representative Sequence: BC037905
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000552983 ENST00000549615 ENST00000332896(uc001tda.3) ENST00000552033
ENST00000548483 ENST00000551065(uc010sur.1 uc010sus.1) ENST00000542893
ENST00000547383 ENST00000550766 ENST00000609189 ENST00000550030 ENST00000548330
ENST00000541813
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CRADD using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CRADD:
hsa-miR-548am hsa-miR-548x
SwitchGear 3'UTR luciferase reporter plasmidCRADD 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CRADD
Predesigned siRNA for gene silencing in human, mouse, rat CRADD
Clone
Products:
     
OriGene clones in human, mouse for CRADD (see all 6)
OriGene ORF clones in mouse, rat for CRADD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRADD (NM_003805)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRADD
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRADD
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CRADD
OriGene qSTAR qPCR primer pairs in human, mouse for CRADD
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRADD
  QuantiTect SYBR Green Assays in human, mouse, rat CRADD
  QuantiFast Probe-based Assays in human, mouse, rat CRADD

Additional mRNA sequence: 

AB451280.1 AB451412.1 AK296225.1 AK314861.1 BC017042.1 BC037905.1 BT009837.1 CR407643.1 
U79115.1 U84388.1 

8 DOTS entries:

DT.413754  DT.100754396  DT.100754397  DT.101959803  DT.121201070  DT.40128065  DT.100754395  DT.91949369 

Selected AceView cDNA sequences (see all 94):

AA626776 CA306602 AA811130 BM127462 BM981491 AW136381 CR407643 CD108947 
AA902585 CD370871 CK724931 AI422699 NM_003805 BU628435 BC017042 CA307146 
AI418811 AI733057 AA745641 CK906099 AA194018 AI203643 CA429170 BF969862 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRADD (see all 8)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1:        -           -     -           -     -                                 
SP2:        -           -     -     -     -     -     -     -                     
SP3:        -                                                                     
SP4:                    -     -     -     -     -     -     -                     
SP5:                                            -     -     -                     


ECgene alternative splicing isoforms for CRADD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CRADD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CRADD Expression
About this image

CRADD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CRADD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591016

UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart,
testis, liver, skeletal muscle, fetal liver and kidney

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CRADD (see all 6): 
          Endothelial Cell Biology in human mouse rat
          p53 Signaling Pathway in human mouse rat
          TNF Ligands & Receptors in human mouse rat
          Neurotoxicity in human mouse rat
          Apoptosis 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CRADD
OriGene qSTAR qPCR primer pairs in human, mouse for CRADD
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRADD
QuantiTect SYBR Green Assays in human, mouse, rat CRADD
QuantiFast Probe-based Assays in human, mouse, rat CRADD
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRADD

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CRADD gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cradd1 , 5 CASP2 and RIPK1 domain containing adaptor with death more1, 5 86.6(n)1
89.95(a)1
  10 (49.26 cM)5
129051  NM_009950.21  NP_034080.11 
 951747465 
chicken
(Gallus gallus)
Aves CRADD1 CASP2 and RIPK1 domain containing adaptor with death more 69.54(n)
70.56(a)
  417900  NM_001030748.1  NP_001025919.1 
lizard
(Anolis carolinensis)
Reptilia CRADD6
CASP2 and RIPK1 domain containing adaptor with dea...
61(a)
1 ↔ 1
5(31393478-31394464)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004898851 death domain-containing protein CRADD-like 59.39(n)
51.27(a)
  100489885  XM_002944140.2  XP_002944186.1 
zebrafish
(Danio rerio)
Actinopterygii cradd1 CASP2 and RIPK1 domain containing adaptor with death more 57.22(n)
48.45(a)
  450046  NM_001006066.1  NP_001006066.1 


ENSEMBL Gene Tree for CRADD (if available)
TreeFam Gene Tree for CRADD (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CRADD gene
1 SIMAP similar gene for CRADD using alignment to 8 protein entries:     CRADD_HUMAN (see all proteins):
CASP2

Find genes that share paralogs with CRADD           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CRADD
PGOHUM00000237835


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CRADD (see all 3612)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0675364
Mental retardation, autosomal recessive 34 (MRT34)4--see VAR_0675362 G R mis40--------
rs1506719151,2
C--91192797(+) CATTT-/TCAGTG
        
TCTCT
1 -- int10--------
rs178371631,2
F,H--91192799(+) TTTTCA/TGTGTC 1 -- int15Minor allele frequency- T:0.01NA NS 344
rs673707331,2
C--91192799(+) TTTTC-/AGTGTC
        
TCTAA
1 -- int10--------
rs1133579961,2
C--91192802(+) TCAGTG/TTCTCT 1 -- int10--------
rs79659921,2
C,A--91199352(+) AAGAGA/CGGGAG 1 -- int1 trp32Minor allele frequency- C:0.25NA WA 4
rs58001151,2
C--91225244(+) TTTGG-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00CSA 2
rs108595751,2
C,A--91230651(+) CCAGGC/TGGGAG 1 -- int10--------
rs108595761,2
A--91230652(+) CAGGTG/TGGAGT 1 -- int10--------
rs356253211,2
C--91250995(+) AACTA-/T/TAAC
        
AAGCA
1 -- int10--------

HapMap Linkage Disequilibrium report for CRADD (94071151 - 94288616 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CRADD (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
esv2671632CNV Deletion23128226
esv2661164CNV Deletion23128226
nsv825CNV Insertion18451855
nsv524248CNV Loss19592680
nsv523282CNV Loss19592680
nsv510310CNV Loss20534489
nsv529049CNV Loss19592680
nsv826CNV Loss18451855
nsv826492CNV Loss20364138
nsv525412CNV Loss19592680

Human Gene Mutation Database (HGMD): CRADD
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CRADD
DNA2.0 Custom Variant and Variant Library Synthesis for CRADD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603454   
OMIM disorders: 614499  
UniProtKB/Swiss-Prot: CRADD_HUMAN, P78560
  • Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptive behavior and
    manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly
    delayed development and significantly impaired cognitive function, precluding independent living and self-care.
    Speech is rudimentary, but articulate; autism is not present. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 2 diseases for CRADD:    
    About MalaCards
    mental retardation, autosomal recessive 34    mental retardation, autosomal recessive 43


    Find genes that share disorders with CRADD           About GenesLikeMe

    Genetic Association Database (GAD): CRADD
    Human Genome Epidemiology (HuGE) Navigator: CRADD (3 documents)

    Export disorders for CRADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRADD gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CRADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAIDD is a new 'death' adaptor molecule. (PubMed id 8985253)1, 2, 3 Duan H. and Dixit V.M. (Nature 1997)
    2. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PubMed id 9044836)1, 2, 3 Ahmad M.... Alnemri E.S. (Cancer Res. 1997)
    3. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)1, 2, 9 Vakifahmetoglu H.... Zhivotovsky B. (Oncogene 2006)
    4. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PubMed id 9695946)1, 2, 9 Chou J.J.... Wagner G. (Cell 1998)
    5. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)1, 2 Puffenberger E.G....Strauss K.A. (PLoS ONE 2012)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    7. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)1, 2 Tinel A. and Tschopp J. (Science 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8738 HGNC: 2340 AceView: CRADD Ensembl:ENSG00000169372 euGenes: HUgn8738
    ECgene: CRADD H-InvDB: CRADD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRADD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRADD gene:
    Search GeneIP for patents involving CRADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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