Aliases for CRADD Gene
External Ids for CRADD Gene
Previous GeneCards Identifiers for CRADD Gene
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for CRADD Gene
CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include Mental Retardation, Autosomal Recessive 34 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are DREAM Repression and Dynorphin Expression and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protease binding and death domain binding.
UniProtKB/Swiss-Prot for CRADD Gene
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.