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Aliases for CRADD Gene

Aliases for CRADD Gene

  • CASP2 And RIPK1 Domain Containing Adaptor With Death Domain 2 3 5
  • RIP-Associated ICH1/CED3-Homologous Protein With Death Domain 2 3
  • RAIDD 3 4
  • RIP-Associated Protein With A Death Domain 4
  • Caspase And RIP Adaptor With Death Domain 3
  • Caspase And RIP Adapter With Death Domain 4
  • Death Domain Containing Protein CRADD 3
  • Death Domain-Containing Protein CRADD 3
  • Death Adaptor Molecule RAIDD 3
  • MRT34 3

External Ids for CRADD Gene

Previous GeneCards Identifiers for CRADD Gene

  • GC12P093603
  • GC12P094592
  • GC12P094004
  • GC12P092573
  • GC12P092595
  • GC12P091137

Summaries for CRADD Gene

Entrez Gene Summary for CRADD Gene

  • This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CRADD Gene

CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are TNFR1 Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot for CRADD Gene

  • Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Gene Wiki entry for CRADD Gene

Additional gene information for CRADD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRADD Gene

Genomics for CRADD Gene

Regulatory Elements for CRADD Gene

Enhancers for CRADD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H093782 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +108.0 107962 5.6 PKNOX1 ARID4B FEZF1 BRCA1 TCF12 ZNF766 GATA2 FOS JUNB REST SOCS2 CRADD GC12P093788 GC12M093698
GH12H093373 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -303.4 -303364 1.7 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 ENSG00000257252 NUDT4 ENSG00000257512 CRADD LOC643339 GC12P093373
GH12H094147 1.6 FANTOM5 ENCODE dbSUPER 1.2 +473.2 473191 5.9 PKNOX1 FOXA2 SIN3A ARID4B FEZF1 DMAP1 YY1 GLIS2 ZNF143 ZNF207 TMCC3 PLXNC1 NR2C1 ENSG00000258365 ENSG00000271382 CRADD GC12P094149 ENSG00000258035
GH12H093447 0.7 FANTOM5 ENCODE 2.2 -229.4 -229407 1.4 BATF EGR2 CRADD UBE2N ENSG00000200011 GC12M093461
GH12H094123 1 FANTOM5 Ensembl ENCODE 1.4 +446.7 446651 1.6 IKZF1 RUNX3 PRDM1 PLXNC1 CRADD LOC441644 LOC105369913
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRADD on UCSC Golden Path with GeneCards custom track

Promoters for CRADD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000055632 149 1401 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Locations for CRADD Gene

Genomic Locations for CRADD Gene
217,490 bases
Plus strand

Genomic View for CRADD Gene

Genes around CRADD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRADD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRADD Gene

Proteins for CRADD Gene

  • Protein details for CRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death domain-containing protein CRADD
    Protein Accession:
    Secondary Accessions:
    • B7Z2Q5

    Protein attributes for CRADD Gene

    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts with PIDD.

    Three dimensional structures from OCA and Proteopedia for CRADD Gene

    Alternative splice isoforms for CRADD Gene


neXtProt entry for CRADD Gene

Post-translational modifications for CRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRADD Gene

Domains & Families for CRADD Gene

Gene Families for CRADD Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CRADD Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains a death domain involved in the binding of RIP protein.
  • Contains a death domain involved in the binding of RIP protein.
  • The CARD domain mediates the interaction with caspase-2.
genes like me logo Genes that share domains with CRADD: view

Function for CRADD Gene

Molecular function for CRADD Gene

GENATLAS Biochemistry:
caspase 2 and RIPK2 adaptor containing with DEATH domain
UniProtKB/Swiss-Prot Function:
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Phenotypes From GWAS Catalog for CRADD Gene

Gene Ontology (GO) - Molecular Function for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9044836
GO:0005515 protein binding IPI 8985253
GO:0030674 protein binding, bridging IPI 9044836
GO:0070513 death domain binding IPI 9044836
genes like me logo Genes that share ontologies with CRADD: view
genes like me logo Genes that share phenotypes with CRADD: view

Human Phenotype Ontology for CRADD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CRADD Gene

MGI Knock Outs for CRADD:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRADD Gene

Localization for CRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRADD Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRADD gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRADD: view

Pathways & Interactions for CRADD Gene

genes like me logo Genes that share pathways with CRADD: view

Gene Ontology (GO) - Biological Process for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 21726810
GO:0007165 signal transduction IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IC 9044836
genes like me logo Genes that share ontologies with CRADD: view

No data available for SIGNOR curated interactions for CRADD Gene

Drugs & Compounds for CRADD Gene

No Compound Related Data Available

Transcripts for CRADD Gene

Unigene Clusters for CRADD Gene

CASP2 and RIPK1 domain containing adaptor with death domain:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRADD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP8: - - - - -

Relevant External Links for CRADD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRADD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRADD Gene

Protein differential expression in normal tissues from HIPED for CRADD Gene

This gene is overexpressed in Rectum (11.9), Cardia (7.4), and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRADD Gene

Protein tissue co-expression partners for CRADD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRADD Gene:


SOURCE GeneReport for Unigene cluster for CRADD Gene:


mRNA Expression by UniProt/SwissProt for CRADD Gene:

Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Evidence on tissue expression from TISSUES for CRADD Gene

  • Nervous system(4.4)
  • Intestine(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CRADD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • skull
  • tooth
  • chest wall
  • heart
  • abdominal wall
  • foot
  • lower limb
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
genes like me logo Genes that share expression patterns with CRADD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRADD Gene

Orthologs for CRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRADD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRADD 33 34
  • 99.83 (n)
(Canis familiaris)
Mammalia CRADD 33 34
  • 88.94 (n)
(Mus musculus)
Mammalia Cradd 33 16 34
  • 86.6 (n)
(Ornithorhynchus anatinus)
Mammalia CRADD 34
  • 79 (a)
(Bos Taurus)
Mammalia CRADD 34
  • 78 (a)
(Monodelphis domestica)
Mammalia CRADD 34
  • 77 (a)
(Gallus gallus)
Aves CRADD 33 34
  • 69.54 (n)
(Anolis carolinensis)
Reptilia CRADD 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489885 33
  • 59.39 (n)
(Danio rerio)
Actinopterygii cradd 33 34
  • 57.22 (n)
Species where no ortholog for CRADD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRADD Gene

Gene Tree for CRADD (if available)
Gene Tree for CRADD (if available)

Paralogs for CRADD Gene

(1) SIMAP similar genes for CRADD Gene using alignment to 8 proteins: Pseudogenes for CRADD Gene

genes like me logo Genes that share paralogs with CRADD: view

No data available for Paralogs for CRADD Gene

Variants for CRADD Gene

Sequence variations from dbSNP and Humsavar for CRADD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs387906861 Pathogenic, Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34) [MIM:614499] 93,850,053(+) GGCTG(C/G)GCCCT intron-variant, downstream-variant-500B, reference, missense
rs141179774 Pathogenic 93,850,180(+) GCAGC(A/G)CTTCG intron-variant, downstream-variant-500B, reference, missense
rs370916968 Pathogenic 93,850,162(+) GGCCT(G/T)CATCC intron-variant, downstream-variant-500B, reference, missense
rs749655461 Pathogenic 93,850,179(+) GGCAG(C/T)GCTTC intron-variant, downstream-variant-500B, reference, missense
rs1000003347 -- 93,884,139(+) TGTCT(C/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRADD Gene

Variant ID Type Subtype PubMed ID
nsv825 CNV insertion 18451855
nsv826 CNV deletion 18451855
nsv826492 CNV loss 20364138
nsv9000 CNV gain 18304495
nsv7234 OTHER inversion 18451855
nsv529049 CNV loss 19592680
nsv525412 CNV loss 19592680
nsv524248 CNV loss 19592680
nsv523282 CNV loss 19592680
nsv510310 OTHER sequence alteration 20534489
nsv477449 CNV novel sequence insertion 20440878
nsv442284 CNV loss 18776908
esv3630403 CNV loss 21293372
esv3630402 CNV loss 21293372
esv3549594 CNV deletion 23714750
esv2671632 CNV deletion 23128226
esv2661164 CNV deletion 23128226

Variation tolerance for CRADD Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRADD Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRADD Gene

Disorders for CRADD Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRADD Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CRADD in MalaCards View complete list of genes associated with diseases


  • Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. {ECO:0000269 PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRADD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRADD: view

No data available for Genatlas for CRADD Gene

Publications for CRADD Gene

  1. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H … Zhivotovsky B (Oncogene 2006) 3 4 22 60
  2. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PMID: 9695946) Chou JJ … Wagner G (Cell 1998) 3 4 22 60
  3. RAIDD is a new 'death' adaptor molecule. (PMID: 8985253) Duan H … Dixit VM (Nature 1997) 2 3 4 60
  4. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PMID: 9044836) Ahmad M … Alnemri ES (Cancer research 1997) 2 3 4 60
  5. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PMID: 22279524) Puffenberger EG … Strauss KA (PloS one 2012) 3 4 60

Products for CRADD Gene

Sources for CRADD Gene

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