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Aliases for CRADD Gene

Aliases for CRADD Gene

  • CASP2 And RIPK1 Domain Containing Adaptor With Death Domain 2 3
  • RAIDD 3 4 6
  • RIP-Associated ICH1/CED3-Homologous Protein With Death Domain 2 3
  • RIP-Associated Protein With A Death Domain 3 4
  • MRT34 3 6
  • Caspase And RIP Adaptor With Death Domain 3
  • Caspase And RIP Adapter With Death Domain 4
  • Death Domain-Containing Protein CRADD 3
  • Death Adaptor Molecule RAIDD 3

External Ids for CRADD Gene

Previous GeneCards Identifiers for CRADD Gene

  • GC12P094592
  • GC12P094004
  • GC12P092573
  • GC12P092595
  • GC12P091137

Summaries for CRADD Gene

Entrez Gene Summary for CRADD Gene

  • The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRADD Gene

CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include mental retardation, autosomal recessive 34 and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Apoptosis and survival Caspase cascade and TWEAK Pathway. GO annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot for CRADD Gene

  • Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Gene Wiki entry for CRADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRADD Gene

Genomics for CRADD Gene

Regulatory Elements for CRADD Gene

Genomic Location for CRADD Gene

93,677,346 bp from pter
93,895,754 bp from pter
218,409 bases
Plus strand

Genomic View for CRADD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRADD Gene

Proteins for CRADD Gene

  • Protein details for CRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death domain-containing protein CRADD
    Protein Accession:
    Secondary Accessions:
    • B7Z2Q5

    Protein attributes for CRADD Gene

    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts with PIDD.

    Three dimensional structures from OCA and Proteopedia for CRADD Gene

    Alternative splice isoforms for CRADD Gene


neXtProt entry for CRADD Gene

Proteomics data for CRADD Gene at MOPED

Post-translational modifications for CRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRADD Gene

Antibody Products

No data available for DME Specific Peptides for CRADD Gene

Domains for CRADD Gene

Protein Domains for CRADD Gene

Graphical View of Domain Structure for InterPro Entry



  • P78560
  • Contains a death domain involved in the binding of RIP protein
  • The CARD domain mediates the interaction with caspase-2
  • Contains 1 CARD domain.
  • Contains 1 death domain.
genes like me logo Genes that share domains with CRADD: view

No data available for Gene Families for CRADD Gene

Function for CRADD Gene

Molecular function for CRADD Gene

GENATLAS Biochemistry: caspase 2 and RIPK2 adaptor containing with DEATH domain
UniProtKB/Swiss-Prot Function: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Gene Ontology (GO) - Molecular Function for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9044836
GO:0005515 protein binding IPI 11156409
GO:0030674 protein binding, bridging IPI 9044836
GO:0070513 death domain binding IPI 9044836
genes like me logo Genes that share ontologies with CRADD: view
genes like me logo Genes that share phenotypes with CRADD: view

Animal Models for CRADD Gene

MGI Knock Outs for CRADD:

Animal Model Products

CRISPR Products

miRNA for CRADD Gene

miRTarBase miRNAs that target CRADD

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRADD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRADD Gene

Localization for CRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRADD Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CRADD Gene COMPARTMENTS Subcellular localization image for CRADD gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with CRADD: view

Pathways for CRADD Gene

genes like me logo Genes that share pathways with CRADD: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 21726810
GO:0007165 signal transduction --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IC 9044836
GO:0042981 regulation of apoptotic process --
genes like me logo Genes that share ontologies with CRADD: view

Transcripts for CRADD Gene

Unigene Clusters for CRADD Gene

CASP2 and RIPK1 domain containing adaptor with death domain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRADD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRADD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP8: - - - - -

Relevant External Links for CRADD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRADD Gene

mRNA expression in normal human tissues for CRADD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRADD Gene

SOURCE GeneReport for Unigene cluster for CRADD Gene Hs.591016

mRNA Expression by UniProt/SwissProt for CRADD Gene

Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney
genes like me logo Genes that share expressions with CRADD: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRADD Gene

Orthologs for CRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRADD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRADD 35
  • 99.83 (n)
  • 99.5 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CRADD 36
  • 78 (a)
(Canis familiaris)
Mammalia CRADD 35
  • 88.94 (n)
  • 87.94 (a)
  • 87 (a)
(Mus musculus)
Mammalia Cradd 35
  • 86.6 (n)
  • 89.95 (a)
Cradd 16
Cradd 36
  • 90 (a)
(Monodelphis domestica)
Mammalia CRADD 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CRADD 36
  • 79 (a)
(Gallus gallus)
Aves CRADD 35
  • 69.54 (n)
  • 70.56 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia CRADD 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489885 35
  • 59.39 (n)
  • 51.27 (a)
(Danio rerio)
Actinopterygii cradd 35
  • 57.22 (n)
  • 48.45 (a)
cradd 36
  • 47 (a)
Species with no ortholog for CRADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRADD Gene

Gene Tree for CRADD (if available)
Gene Tree for CRADD (if available)

Paralogs for CRADD Gene

Selected SIMAP similar genes for CRADD Gene using alignment to 8 proteins: Pseudogenes for CRADD Gene

genes like me logo Genes that share paralogs with CRADD: view

No data available for Paralogs for CRADD Gene

Variants for CRADD Gene

Sequence variations from dbSNP and Humsavar for CRADD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1585 -- 93,760,349(+) AAACA(C/T)CAGCC intron-variant
rs174825 -- 93,806,575(+) CTCAT(C/G)TGCAT intron-variant
rs174826 -- 93,776,501(+) CTAAG(C/G)CTTTT intron-variant
rs183202 -- 93,806,581(+) TGCAT(C/G)TGCAC intron-variant
rs187890 -- 93,820,506(-) agtgg(C/T)atgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRADD Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv825 CNV Insertion 18451855
nsv899440 CNV Gain 21882294
nsv510310 CNV Loss 20534489
nsv826 CNV Loss 18451855
esv2661164 CNV Deletion 23128226
esv2671632 CNV Deletion 23128226
nsv442284 CNV CNV 18776908
nsv826492 CNV Loss 20364138
nsv523282 CNV Loss 19592680
nsv9000 CNV Gain 18304495
nsv529049 CNV Loss 19592680
nsv524248 CNV Loss 19592680
nsv525412 CNV Loss 19592680

Relevant External Links for CRADD Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRADD Gene

Disorders for CRADD Gene

(1) OMIM Diseases for CRADD Gene (603454)


  • Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. {ECO:0000269 PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRADD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRADD: view

Publications for CRADD Gene

  1. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PMID: 9695946) Chou J.J. … Wagner G. (Cell 1998) 3 4 23
  2. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H. … Zhivotovsky B. (Oncogene 2006) 3 4 23
  3. RAIDD is a new 'death' adaptor molecule. (PMID: 8985253) Duan H. … Dixit V.M. (Nature 1997) 2 3 4
  4. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PMID: 9044836) Ahmad M. … Alnemri E.S. (Cancer Res. 1997) 2 3 4
  5. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PMID: 15073321) Tinel A. … Tschopp J. (Science 2004) 3 4

Products for CRADD Gene

Sources for CRADD Gene

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