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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRABP2 Gene

protein-coding GIFtS: 63
GCID: GC01M156669

cellular retinoic acid binding protein 2

(Previous name: cellular retinoic acid-binding protein 2 )

Explore 38 diseases affiliated with
CRABP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cellular Retinoic Acid Binding Protein 2¹ ²
CRABP-II¹ ² ³
Cellular Retinoic Acid-Binding Protein 2¹ ²
Cellular Retinoic Acid-Binding Protein II² ³
RBP6² ⁵

External Ids:	HGNC: 2339¹	Entrez Gene: 1382²	Ensembl: ENSG00000143320⁷	OMIM: 180231⁵	UniProtKB: P29373³

Export aliases for CRABP2 gene to outside databases

Previous GC identifers: GC01M154538 GC01M152434 GC01M153447 GC01M153886 GC01M153482 GC01M154936 GC01M128026

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRABP2:

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and

lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which

facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid

signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively

spliced transcript variants encoding the same protein have been found for this gene.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373

Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid

receptors

Gene Wiki entry for CRABP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRABP2 gene promoter:
COUP-TF1 AP-2alpha isoform 3 COUP HNF-4alpha2 AP-2alpha isoform 2 HNF-4alpha1 COUP-TF AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRABP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CRABP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRABP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21.3

CRABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRABP2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M156669: view genomic region (about GC identifiers)

Start:	156,669,398 bp from pter	End:	156,675,608 bp from pter
Size:	6,211 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373 (See protein sequence)

Recommended Name: Cellular retinoic acid-binding protein 2

Size: 138 amino acids; 15693 Da

Subunit: Interacts with RXR and RARA (By similarity). Interacts with importin alpha

Subcellular location: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change

exposes a nuclear localization motif and the protein is transported into the nucleus

6/30 PDB 3D structures from and Proteopedia for CRABP2 (see all 30):

1BLR (3D)

1BM5 (3D)

1CBQ (3D)

1CBS (3D)

1XCA (3D)

2CBS (3D)

Secondary accessions: B2R4Z8 D3DVC5 F1T098 Q6ICN6

Explore the universe of human proteins at neXtProt for CRABP2: NX_P29373

Post-translational modifications:

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent

nuclear translocation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29373

CRABP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186652.1 NP_001869.1

ENSEMBL proteins:

ENSP00000357205 ENSP00000357204 ENSP00000357203

Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for CRABP2
	ProSpec Recombinant Protein for CRABP2
	Uscn Proteins for CRABP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005783	endoplasmic reticulum	IEA	--

CRABP2 for ontologies About GeneDecksing

CRABP2 Antibody Products:

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	GenScript Custom Assay Services for CRABP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRABP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRABP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR012674 Calycin

IPR011038 Calycin-like

IPR000463 Fatty_acid-bd

IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry P29373

ProtoNet protein and cluster: P29373

1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373

Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior

Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373

Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid

receptors

Induction: By retinoic acid

Genatlas biochemistry entry for CRABP2:

retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)

miRNA Products:		OriGene 3'-UTR Clone: CRABP2 Browse MicroRNA Expression Plasmids
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		hsa-miR-3163 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548v hsa-miR-4282 hsa-miR-4260
		SwitchGear 3'UTR luciferase reporter plasmid: CRABP2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRABP2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001972	retinoic acid binding	IEA	--
GO:0005215	transporter activity	IEA	--
GO:0005501	retinoid binding	TAS	1334086
GO:0016918	retinal binding	IEA	--
GO:0019841	retinol binding	IEA	--

CRABP2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CRABP2: Crabp2^tm1Ut Crabp2^tm1Ipc
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crabp2):

hearing/vestibular/ear

limbs/digits/tail

mortality/aging

CRABP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

all-trans-Retinoic Acid Signaling in Brain

0.59

RAR-Gamma-RXR-Alpha Degradation

0.54

HIV Infection

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

0.28

all-trans-Retinoic Acid Mediated Apoptosis

all-trans-Retinoic Acid Mediated Apoptosis

1.00

Vitamin A and carotenoid metabolism

Vitamin A and carotenoid metabolism

1.00

Apoptotic Pathways in Synovial Fibroblasts

Nuclear Receptor Activation by Vitamin-A

0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CRABP2

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRABP2

	Nuclear Receptor Activation by Vitamin-A
	all-trans-Retinoic Acid Signaling in Brain
	all-trans-Retinoic Acid Mediated Apoptosis
	RAR-Gamma-RXR-Alpha Degradation

1 GeneGo (Thomson Reuters) Pathway for CRABP2

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 BioSystems Pathway for CRABP2

Vitamin A and carotenoid metabolism

CRABP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRABP2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for CRABP2 (P29373³ ENSP00000357204⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCND3	P30281³, ENSP00000362082⁴	I2D: score=3 STRING: ENSP00000362082
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
APPBP2	Q92624³	I2D: score=1
UBA5	Q9GZZ9³	I2D: score=1
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	TAS	1334086
GO:0007165	signal transduction	TAS	1654334
GO:0008544	epidermis development	TAS	1654334
GO:0035115	embryonic forelimb morphogenesis	IEA	--
GO:0042573	retinoic acid metabolic process	IEA	--

CRABP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRABP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRABP2

1 HMDB Compound for CRABP2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Retinoic acid	Retinoate (see all 21)	302-79-4	--

5 DrugBank Compounds for CRABP2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alitretinoin	9-cis-Retinoic acid (see all 4)	5300-03-8	carrier	--	17407572 16109390 16166294 16813970 17667529
Tretinoin	All Trans Retinoic Acid (see all 5)	302-79-4	transporter	substrate	16109390 20552429 17929112
1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene	--	--	carrier	--	10592235
6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID	--	--	carrier	--	10592235
9-(4-HYDROXY-2,6-DIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-4,6,8-TRIENOIC ACID	--	--	carrier	--	10592235

10/21 Novoseek chemical compound relationships for CRABP2 gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	90.8	549	11909957 (8), 7998926 (7), 1314862 (7), 9865735 (6) (see all 99)
retinoid	87.1	47	8382035 (2), 8396608 (2), 12153175 (2), 8648186 (2) (see all 27)
4-oxoretinol	83.1	1	9377581 (1)
vitamin a	67.5	10	11288179 (1), 11956581 (1), 15152096 (1), 19016711 (1) (see all 8)
adapalene	54	7	8396608 (3), 9990415 (1)
carboxylate	24.5	1	7704533 (1)
ethidium bromide	13	2	1282237 (1), 9215617 (1)
estrogen	10.2	4	15870697 (2), 12727970 (1)
proline	8.52	2	7593315 (1)
actinomycin d	5.44	2	7998926 (1)

Search CenterWatch for drugs/clinical trials and news about CRABP2 / RABP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRABP2 gene (2 alternative transcripts):

NM_001199723.1 NM_001878.3

Unigene Cluster for CRABP2:

Cellular retinoic acid binding protein 2

Hs.405662 [show with all ESTs]

Unigene Representative Sequence: BI194589

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368222(uc001fpr.3 uc021pbi.1) ENST00000368221 ENST00000368220

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRABP2

Additional cDNA sequence:

AB593017.1 AK312007.1 BC001109.2 BT019827.1 CR450357.1 M68867.1

7 DOTS entries:

DT.118643 DT.95335972 DT.95335973 DT.100763186 DT.100763187 DT.91983493 DT.95336018

24/475 AceView cDNA sequences (see all 475):

CA489092 BU539242 AA707836 BM842319 BU197351 BU944730 BM461388 BF446284

BQ690797 BC001109 BU190232 BU857637 BQ688114 BU957159 AA364426 BQ888855

AI424411 AI125761 BQ931541 BF001188 BE618131 AI825918 BM450779 AI652832

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b
SP1:					-
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for CRABP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRABP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCACCGCCC

About this image

CRABP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Zeugopod Epiphyseal End

Bone

Brain

Eye

Kidney

Kidney

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See CRABP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRABP2

SOURCE GeneReport for Unigene cluster: Hs.405662

SABiosciences Expression via Pathway-Focused PCR Array including CRABP2:

Embryonic Stem Cells in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CRABP2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CRABP2⁶	--	77(a)	1 ↔ 1	GL343640.1(296818-299909)
African clawed frog (Xenopus laevis)	Amphibia	crabp2-A²	cellular retinoic acid binding protein 2	80.89(n)		S74933.1
zebrafish (Danio rerio)	Actinopterygii	crabp2²	cellular retinoic acid binding protein 2	74.94(n)		171480 AF497478.1
fruit fly (Drosophila melanogaster)	Insecta	fabp⁶	fatty acid bindin protein	34(a)	possible ortholog	3R(7385612-7392771)

ENSEMBL Gene Tree for CRABP2 (if available)
TreeFam Gene Tree for CRABP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRABP2 gene

FABP5² RBP5² FABP9² FABP12² FABP4² RBP1² FABP3² CRABP1²

RBP2² FABP2² PMP2² FABP7² RBP7²

16 SIMAP similar genes for CRABP2 using alignment to 2 protein entries: RABP2_HUMAN (see all proteins):

CRABP1 DKFZp547J2313 FABP7 FABP3 PMP2 FABP5

RBP5 FABP5P3 FABP12 FABP9 FABP4 RBP1

RBP7 RBP2 FABP2 FABP1

CRABP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193286868^1,2		--	156668955(+)	`TGGGTG/TCCGTT`	2	--	ds500¹		0	--	--	--	--
rs185513301^1,2		--	156668956(+)	`GGGTGC/TCGTTG`	2	--	ds500¹		0	--	--	--	--
rs145598153^1,2		--	156668957(+)	`GGTGCC/TGTTGA`	2	--	ds500¹		0	--	--	--	--
rs147715637^1,2		--	156668978(+)	`AACCAG/TGTGGG`	2	--	ds500¹		0	--	--	--	--
rs188839637^1,2		--	156669050(+)	`TGGAGG/TAGGAG`	2	--	ds500¹		0	--	--	--	--
rs146196396^1,2	C,	--	156669088(+)	`ATGGG-/AGAAGGTG`	2	--	ds500¹		0	--	--	--	--
rs115422714^1,2	F,	--	156669115(+)	`AGAGCC/GCAGTG`	2	--	ds500¹		1		WA	118
rs112729315^1,2	C,	--	156669172(+)	`CCAGAG/ACAGGA`	2	--	ds500¹		1		NA	2
rs146896532^1,2		--	156669249(+)	`GGGTGG/TTGGTT`	2	--	ds500¹		0	--	--	--	--
rs115225863^1,2	F,	--	156669350(+)	`GGCAAG/AGTTGA`	2	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for CRABP2 (156669398 - 156675608 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRABP2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CRABP2 for disorders           About GeneDecksing

OMIM gene information: 180231    OMIM disorders: --

20/38 diseases for CRABP2 (see all 38):    About MalaCards

neural tube defect cholesterol uterine fibroid polycythemia vera

spontaneous abortion oral squamous cell carcinoma acute promyelocytic leukemia squamous cell carcinoma

lipodystrophy pulmonary emphysema basal cell carcinoma polycythemia

emphysema skin disease keratoacanthoma hyperlipidemia

renal cell carcinoma wilms tumor carcinoma ichthyosis

10/15 Novoseek disease relationships for CRABP2 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma embryonal	60.2	2	1327537 (1)
hyperlipidemia familial combined	46.8	3	12628590 (1), 17484622 (1)
carcinoma basal cell	29.8	2	8618041 (2)
carcinoma squamous cell	26.5	1	8618041 (1)
lipodystrophy	21.4	5	12844477 (2), 12628590 (1)
leukemia promyelocytic acute	16.1	3	9865735 (2)
breast cancer	9.12	15	15870697 (4), 17187826 (2), 7743514 (2), 9135005 (1) (see all 5)
carcinoma	8.6	8	12907615 (3), 16166294 (2), 11909957 (2), 16211222 (1)
psoriasis	7.24	1	1335801 (1)
breast carcinoma	2.98	2	17187826 (1), 20005186 (1)

Genetic Association Database (GAD): CRABP2
Human Genome Epidemiology (HuGE) Navigator: CRABP2 (4 documents)

Export disorders for CRABP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRABP2 gene, integrated from 9 sources (see all 193):
(articles sorted by number of sources associating them with CRABP2)

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Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PubMed id 1654334)^{1, 2, 3, 9} Astroem A....Voorhees J.J. (1991)
Direct channeling of retinoic acid between cellular retinoic acid- binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (PubMed id 11909957)^{1, 2, 9} Budhu A.S. and Noy N. (2002)
A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. (PubMed id 15866176)^{1, 2, 9} Sessler R.J. and Noy N. (2005)
Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid. (PubMed id 1334086)^{1, 2, 9} Aastroem A.... Voorhees J.J. (1992)
The molecular cloning and expression of two CRABP cDNAs from human skin. (PubMed id 1309505)^{1, 2, 9} Eller M.S.... Gilchrest B.A. (1992)
Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. (PubMed id 7704533)^{1, 2, 9} Kleywegt G.J....Jones T.A. (1994)
Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids. (PubMed id 10531482)^{1, 2, 9} Chaudhuri B.N.... Jones T.A. (1999)
NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. (PubMed id 9737883)^{1, 2, 9} Wang L. and Yan H. (1998)
Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation. (PubMed id 21998312)^{1, 2} Majumdar A.... Noy N. (2011)
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)^{1, 2} Oshikawa M.... Kato S. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1382	HGNC: 2339	AceView: CRABP2	Ensembl:ENSG00000143320	euGenes: HUgn1382
ECgene: CRABP2	H-InvDB: CRABP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRABP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRABP2 gene
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Patent Information for CRABP2 gene:
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cellular retinoic acid binding protein 2

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cellular retinoic acid binding protein 2

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