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Aliases for CRABP2 Gene

Aliases for CRABP2 Gene

  • Cellular Retinoic Acid Binding Protein 2 2 3
  • Cellular Retinoic Acid-Binding Protein II 3 4
  • Cellular Retinoic Acid-Binding Protein 2 2 3
  • CRABP-II 3 4
  • RBP6 3 6

External Ids for CRABP2 Gene

Summaries for CRABP2 Gene

Entrez Gene Summary for CRABP2 Gene

  • This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

GeneCards Summary for CRABP2 Gene

CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Vitamin A and carotenoid metabolism. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for CRABP2 Gene

  • Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors

Gene Wiki entry for CRABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP2 Gene

Genomics for CRABP2 Gene

Genomic Location for CRABP2 Gene

Start:
156,699,606 bp from pter
End:
156,713,174 bp from pter
Size:
13,569 bases
Orientation:
Minus strand

Genomic View for CRABP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP2 Gene

Proteins for CRABP2 Gene

  • Protein details for CRABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29373-RABP2_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 2
    Protein Accession:
    P29373
    Secondary Accessions:
    • B2R4Z8
    • D3DVC5
    • F1T098
    • Q6ICN6

    Protein attributes for CRABP2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    • Interacts with RXR and RARA (By similarity). Interacts with importin alpha.

    Three dimensional structures from OCA and Proteopedia for CRABP2 Gene

neXtProt entry for CRABP2 Gene

Proteomics data for CRABP2 Gene at MOPED

Post-translational modifications for CRABP2 Gene

  • Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP2 Gene

No data available for DME Specific Peptides for CRABP2 Gene

Domains for CRABP2 Gene

Gene Families for CRABP2 Gene

HGNC:
  • FABP :Fatty acid binding protein family

UniProtKB/Swiss-Prot:

RABP2_HUMAN
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior:
    • P29373
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.:
    • P29373
genes like me logo Genes that share domains with CRABP2: view

Function for CRABP2 Gene

Molecular function for CRABP2 Gene

GENATLAS Biochemistry: retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)
UniProtKB/Swiss-Prot Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors
UniProtKB/Swiss-Prot Induction: By retinoic acid

Gene Ontology (GO) - Molecular Function for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 1334086
GO:0005515 protein binding IPI 25416956
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with CRABP2: view

Phenotypes for CRABP2 Gene

genes like me logo Genes that share phenotypes with CRABP2: view

Animal Models for CRABP2 Gene

MGI Knock Outs for CRABP2:

miRNA for CRABP2 Gene

miRTarBase miRNAs that target CRABP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRABP2 Gene

Localization for CRABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP2 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRABP2 Gene COMPARTMENTS Subcellular localization image for CRABP2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRABP2: view

Pathways for CRABP2 Gene

genes like me logo Genes that share pathways with CRABP2: view

Pathways by source for CRABP2 Gene

Gene Ontology (GO) - Biological Process for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002138 retinoic acid biosynthetic process IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 1334086
GO:0006810 transport IEA --
GO:0007165 signal transduction TAS 1654334
GO:0008544 epidermis development TAS 1654334
genes like me logo Genes that share ontologies with CRABP2: view

Compounds for CRABP2 Gene

(1) HMDB Compounds for CRABP2 Gene

Compound Synonyms Cas Number PubMed IDs
Retinoic acid
  • Retinoate
302-79-4

(5) Drugbank Compounds for CRABP2 Gene

(21) Novoseek inferred chemical compound relationships for CRABP2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 90.8 245
retinoid 87.1 32
4-oxoretinol 83.1 1
vitamin a 67.5 8
adapalene 54 4
genes like me logo Genes that share compounds with CRABP2: view

Transcripts for CRABP2 Gene

Unigene Clusters for CRABP2 Gene

Cellular retinoic acid binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CRABP2 Gene

GeneLoc Exon Structure for
CRABP2
ECgene alternative splicing isoforms for
CRABP2

Expression for CRABP2 Gene

mRNA expression in normal human tissues for CRABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP2 Gene

This gene is overexpressed in Esophagus - Mucosa (19.1), Vagina (9.2), and Cervix - Ectocervix (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRABP2 Gene

SOURCE GeneReport for Unigene cluster for CRABP2 Gene Hs.405662

genes like me logo Genes that share expressions with CRABP2: view

Orthologs for CRABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRABP2 36
  • 99.76 (n)
  • 100 (a)
CRABP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRABP2 36
  • 93.96 (n)
  • 97.1 (a)
CRABP2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRABP2 36
  • 89.86 (n)
  • 95.65 (a)
CRABP2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crabp2 36
  • 89.37 (n)
  • 93.48 (a)
Crabp2 16
Crabp2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRABP2 37
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRABP2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRABP2 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia crabp2-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp2 36
  • 80.19 (n)
  • 83.33 (a)
Str.1681 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9548 36
zebrafish
(Danio rerio)
Actinopterygii crabp2 36
crabp2a 37
  • 73 (a)
OneToMany
crabp2a 37
  • 73 (a)
OneToMany
crabp2b 37
  • 66 (a)
OneToMany
LOC100332539 36
  • 70.77 (n)
  • 74.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta fabp 37
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 37
  • 38 (a)
ManyToMany
lbp-6 37
  • 44 (a)
ManyToMany
lbp-7 37
  • 36 (a)
ManyToMany
lbp-8 37
  • 35 (a)
ManyToMany
lbp-9 37
  • 30 (a)
ManyToMany
Species with no ortholog for CRABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP2 Gene

ENSEMBL:
Gene Tree for CRABP2 (if available)
TreeFam:
Gene Tree for CRABP2 (if available)

Paralogs for CRABP2 Gene

Paralogs for CRABP2 Gene

Selected SIMAP similar genes for CRABP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRABP2: view

Variants for CRABP2 Gene

Sequence variations from dbSNP and Humsavar for CRABP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1803320 -- 156,700,991(-) GAGAT(C/T)AAACA reference, synonymous-codon
rs2236795 -- 156,705,979(-) GCGGG(C/T)GGGGT upstream-variant-2KB, intron-variant
rs3806412 -- 156,706,761(+) CTGGC(G/T)GGATG upstream-variant-2KB, intron-variant
rs3806413 -- 156,706,963(+) CTGGC(C/T)CCTCC upstream-variant-2KB, intron-variant
rs4387174 -- 156,703,392(+) AAGAC(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP2 Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv831648 CNV Loss 17160897
esv2675449 CNV Deletion 23128226

Relevant External Links for CRABP2 Gene

HapMap Linkage Disequilibrium report
CRABP2

Disorders for CRABP2 Gene

(15) Novoseek inferred disease relationships for CRABP2 Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 60.2 1
hyperlipidemia familial combined 46.8 2
carcinoma basal cell 29.8 2
carcinoma squamous cell 26.5 1
lipodystrophy 21.4 3

Relevant External Links for CRABP2

Genetic Association Database (GAD)
CRABP2
Human Genome Epidemiology (HuGE) Navigator
CRABP2
genes like me logo Genes that share disorders with CRABP2: view

No data available for UniProtKB/Swiss-Prot for CRABP2 Gene

Publications for CRABP2 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Astroem A. … Voorhees J.J. (J. Biol. Chem. 1991) 2 3 4 23
  2. Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. (PMID: 7704533) Kleywegt G.J. … Jones T.A. (Structure 1994) 3 4 23
  3. The molecular cloning and expression of two CRABP cDNAs from human skin. (PMID: 1309505) Eller M.S. … Gilchrest B.A. (Exp. Cell Res. 1992) 3 4 23
  4. NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. (PMID: 9737883) Wang L. … Yan H. (Biochemistry 1998) 3 4 23
  5. Direct channeling of retinoic acid between cellular retinoic acid- binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (PMID: 11909957) Budhu A.S. … Noy N. (Mol. Cell. Biol. 2002) 3 4 23

Products for CRABP2 Gene

Sources for CRABP2 Gene

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