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CRABP2 Gene

protein-coding   GIFtS: 64
GCID: GC01M156669

Cellular Retinoic Acid Binding Protein 2

(Previous name: cellular retinoic acid-binding protein 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cellular Retinoic Acid Binding Protein 21 2
Cellular Retinoic Acid-Binding Protein 21 2
Cellular Retinoic Acid-Binding Protein II2 3
CRABP-II2 3
RBP62 5

External Ids:    HGNC: 23391   Entrez Gene: 13822   Ensembl: ENSG000001433207   OMIM: 1802315   UniProtKB: P293733   

Export aliases for CRABP2 gene to outside databases

Previous GC identifers: GC01M154538 GC01M152434 GC01M153447 GC01M153886 GC01M153482 GC01M154936 GC01M128026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRABP2 Gene:
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and
lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein,
which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the
retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol.
Alternatively spliced transcript variants encoding the same protein have been found for this gene.(provided by
RefSeq, Dec 2010)

GeneCards Summary for CRABP2 Gene:
CRABP2 (cellular retinoic acid binding protein 2) is a protein-coding gene. Diseases associated with CRABP2 include uterine fibroid, and pulmonary emphysema. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373
Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic
acid receptors

Gene Wiki entry for CRABP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRABP2 gene promoter:
         COUP-TF1   AP-2alpha isoform 3   COUP   HNF-4alpha2   AP-2alpha isoform 2   HNF-4alpha1   COUP-TF   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRABP2 promoter sequence
   Search Chromatin IP Primers for CRABP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRABP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21.3

CRABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRABP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156669:  view genomic region     (about GC identifiers)

Start:
156,669,398 bp from pter      End:
156,675,608 bp from pter
Size:
6,211 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373 (See protein sequence)
Recommended Name: Cellular retinoic acid-binding protein 2  
Size: 138 amino acids; 15693 Da
Subunit: Interacts with RXR and RARA (By similarity). Interacts with importin alpha
Selected PDB 3D structures from and Proteopedia for CRABP2 (see all 34):
1BLR (3D)        1BM5 (3D)        1CBQ (3D)        1CBS (3D)        1XCA (3D)        2CBS (3D)    
Secondary accessions: B2R4Z8 D3DVC5 F1T098 Q6ICN6

Explore the universe of human proteins at neXtProt for CRABP2: NX_P29373

Explore proteomics data for CRABP2 at MOPED

Post-translational modifications: 

  • Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent
    nuclear translocation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRABP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186652.1  NP_001869.1  

    ENSEMBL proteins: 
     ENSP00000357205   ENSP00000357204   ENSP00000357203  

    CRABP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P29373

    ProtoNet protein and cluster: P29373

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: RABP2_HUMAN, P29373
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    CRABP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RABP2_HUMAN, P29373
    Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic
    acid receptors
    Induction: By retinoic acid

         Genatlas biochemistry entry for CRABP2:
    retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IEA--
    GO:0005215transporter activity IEA--
    GO:0005501retinoid binding TAS1334086
    GO:0016918retinal binding IEA--
    GO:0019841retinol binding IEA--
         
    CRABP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crabp2):
     hearing/vestibular/ear  limbs/digits/tail  mortality/aging 

    CRABP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRABP2: Crabp2tm1Ut Crabp2tm1Ipc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRABP2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRABP2

    miRNA
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    miRTarBase miRNAs that target CRABP2:
    hsa-mir-375 (MIRT019800)

    Block miRNA regulation of human, mouse, rat CRABP2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CRABP2:
    hsa-miR-3163 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548v hsa-miR-4282 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCRABP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CRABP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRABP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RABP2_HUMAN, P29373: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change
    exposes a nuclear localization motif and the protein is transported into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CRABP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRABP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    all-trans-Retinoic Acid Signaling in Brain0.71
    RAR-Gamma-RXR-Alpha Degradation0.62
    2Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    3Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism
    4Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes
    5all-trans-Retinoic Acid Mediated Apoptosis
    all-trans-Retinoic Acid Mediated Apoptosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRABP2
        Nuclear Receptor Activation by Vitamin-A
    all-trans-Retinoic Acid Signaling in Brain
    all-trans-Retinoic Acid Mediated Apoptosis
    RAR-Gamma-RXR-Alpha Degradation

    1 GeneGo (Thomson Reuters) Pathway for CRABP2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for CRABP2
        Vitamin A and carotenoid metabolism



        Pathway & Disease-focused RT2 Profiler PCR Array including CRABP2: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRABP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CRABP2 (P293733 ENSP000003572044) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCND3P302813, ENSP000003620824I2D: score=3 STRING: ENSP00000362082
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    APPBP2Q926243I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    EP300ENSP000002632534STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS1334086
    GO:0007165signal transduction TAS1654334
    GO:0008544epidermis development TAS1654334
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0042573retinoic acid metabolic process IEA--

    CRABP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRABP2 (RABP2)

    1 HMDB Compound for CRABP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinoic acidRetinoate (see all 21)302-79-4--

    5 DrugBank Compounds for CRABP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8carrier--17407572 16109390 16166294 16813970 17667529
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4transportersubstrate16109390 20552429 17929112
    1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene-- --carrier--10592235
    6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID-- --carrier--10592235
    9-(4-HYDROXY-2,6-DIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-4,6,8-TRIENOIC ACID-- --carrier--10592235

    Selected Novoseek inferred chemical compound relationships for CRABP2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 90.8 549 11909957 (8), 7998926 (7), 1314862 (7), 9865735 (6) (see all 99)
    retinoid 87.1 47 8382035 (2), 8396608 (2), 12153175 (2), 8648186 (2) (see all 27)
    4-oxoretinol 83.1 1 9377581 (1)
    vitamin a 67.5 10 11288179 (1), 11956581 (1), 15152096 (1), 19016711 (1) (see all 8)
    adapalene 54 7 8396608 (3), 9990415 (1)
    carboxylate 24.5 1 7704533 (1)
    ethidium bromide 13 2 1282237 (1), 9215617 (1)
    estrogen 10.2 4 15870697 (2), 12727970 (1)
    proline 8.52 2 7593315 (1)
    actinomycin d 5.44 2 7998926 (1)



    CRABP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRABP2 gene (2 alternative transcripts): 
    NM_001199723.1  NM_001878.3  

    Unigene Cluster for CRABP2:

    Cellular retinoic acid binding protein 2
    Hs.405662  [show with all ESTs]
    Unigene Representative Sequence: BI194589
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368222(uc001fpr.3 uc021pbi.1) ENST00000368221 ENST00000368220

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    Additional mRNA sequence: 

    AB593017.1 AK312007.1 BC001109.2 BT019827.1 CR450357.1 M68867.1 

    7 DOTS entries:

    DT.118643  DT.95335972  DT.95335973  DT.100763186  DT.100763187  DT.91983493  DT.95336018 

    Selected AceView cDNA sequences (see all 475):

    BU860330 AA291519 CA487722 AI424411 AA402826 BF001188 CK818770 BU161912 
    BM465180 BQ685981 BU542139 AA707836 AA405200 CA488797 N95154 AI825918 
    BQ440022 BU153598 BM762048 AA364426 BM682033 BU553974 AA476295 AI950201 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:              -                                       
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for CRABP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRABP2 expression in normal human tissues (normalized intensities)      CRABP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACCGCCC
    CRABP2 Expression
    About this image


    CRABP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Cranial Neural Crest
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced cells
    CRABP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRABP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405662
        Pathway & Disease-focused RT2 Profiler PCR Array including CRABP2: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRABP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRABP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crabp21 , 5 cellular retinoic acid binding protein II1, 5 89.37(n)1
    93.48(a)1
      3 (38.78 cM)5
    129041  NM_007759.21  NP_031785.11 
     879486665 
    chicken
    (Gallus gallus)
    Aves CRABP26
    Cellular retinoic acid-binding protein 2
    76(a)
    1 ↔ 1
    25(468703-470859)
    lizard
    (Anolis carolinensis)
    Reptilia CRABP26
    cellular retinoic acid binding protein 2
    86(a)
    1 ↔ 1
    GL343640.1(281418-302267)
    African clawed frog
    (Xenopus laevis)
    Amphibia crabp2-A2 cellular retinoic acid binding protein 2 80.89(n)    S74933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crabp22 cellular retinoic acid binding protein 2 74.94(n)   171480  AF497478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fabp6
    fatty acid bindin protein
    33(a)
    1 → many
    3R(7385612-7392771)
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-66
    lbp-56
    (see all 5)
    Protein LBP-5 (lbp-5) mRNA, complete cds
    (see all 5)
    44(a)
    38(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(6728285-6729376) WBGene00002258
    I(6731269-6732280) WBGene00002257


    ENSEMBL Gene Tree for CRABP2 (if available)
    TreeFam Gene Tree for CRABP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRABP2 gene
    FABP52  RBP52  FABP92  FABP122  FABP42  FABP32  RBP12  RBP22  
    CRABP12  FABP22  PMP22  FABP72  RBP72  
    16 SIMAP similar genes for CRABP2 using alignment to 2 protein entries:     RABP2_HUMAN (see all proteins):
    CRABP1    DKFZp547J2313    FABP7    FABP3    PMP2    FABP5
    RBP5    FABP5P3    FABP12    FABP9    FABP4    RBP1
    RBP7    RBP2    FABP2    FABP1

    CRABP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRABP2 (see all 187)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932868681,2
    --156668955(+) TGGGTG/TCCGTT 2 -- ds50010--------
    rs1855133011,2
    --156668956(+) GGGTGC/TCGTTG 2 -- ds50010--------
    rs1455981531,2
    --156668957(+) GGTGCC/TGTTGA 2 -- ds50010--------
    rs1477156371,2
    C--156668978(+) AACCAG/TGTGGG 2 -- ds50010--------
    rs1888396371,2
    --156669050(+) TGGAGG/TAGGAG 2 -- ds50010--------
    rs1461963961,2
    C--156669088(+) ATGGG-/AGAAAGGT 2 -- ds50010--------
    rs1154227141,2
    F--156669115(+) AGAGCC/GCAGTG 2 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1127293151,2
    C,F--156669172(+) CCAGAG/ACAGGA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1468965321,2
    --156669249(+) GGGTGG/TTGGTT 2 -- ds50010--------
    rs1152258631,2
    F--156669350(+) GGCAAG/AGTTGA 2 -- ds50011Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CRABP2 (156669398 - 156675608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRABP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675449CNV Deletion23128226
    nsv523181CNV Loss19592680
    nsv831648CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRABP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRABP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180231    OMIM disorders: --

    Selected diseases for CRABP2 (see all 30):    About MalaCards
    uterine fibroid    pulmonary emphysema    keratoacanthoma    lipodystrophy
    acute promyelocytic leukemia    skin disease    polycythemia vera    acne
    polycythemia    neural tube defects    basal cell carcinoma    teratocarcinoma
    papilloma    leiomyoma    wilms tumor    oral squamous cell carcinoma
    medulloblastoma    neuroblastoma    psoriasis    osteosarcoma


    CRABP2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CRABP2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 60.2 2 1327537 (1)
    hyperlipidemia familial combined 46.8 3 12628590 (1), 17484622 (1)
    carcinoma basal cell 29.8 2 8618041 (2)
    carcinoma squamous cell 26.5 1 8618041 (1)
    lipodystrophy 21.4 5 12844477 (2), 12628590 (1)
    leukemia promyelocytic acute 16.1 3 9865735 (2)
    breast cancer 9.12 15 15870697 (4), 17187826 (2), 7743514 (2), 9135005 (1) (see all 5)
    carcinoma 8.6 8 12907615 (3), 16166294 (2), 11909957 (2), 16211222 (1)
    psoriasis 7.24 1 1335801 (1)
    breast carcinoma 2.98 2 17187826 (1), 20005186 (1)

    Genetic Association Database (GAD): CRABP2
    Human Genome Epidemiology (HuGE) Navigator: CRABP2 (4 documents)

    Export disorders for CRABP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRABP2 gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with CRABP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PubMed id 1654334)1, 2, 3, 9 Astroem A....Voorhees J.J. (J. Biol. Chem. 1991)
    2. Direct channeling of retinoic acid between cellular retinoic acid- binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (PubMed id 11909957)1, 2, 9 Budhu A.S. and Noy N. (Mol. Cell. Biol. 2002)
    3. Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol. (PubMed id 17484622)1, 4, 9 Salazar J....Ribalta J. (Clin. Chem. Lab. Med. 2007)
    4. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. (PubMed id 15866176)1, 2, 9 Sessler R.J. and Noy N. (Mol. Cell 2005)
    5. Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid. (PubMed id 1334086)1, 2, 9 Aastroem A.... Voorhees J.J. (J. Biol. Chem. 1992)
    6. The molecular cloning and expression of two CRABP cDNAs from human skin. (PubMed id 1309505)1, 2, 9 Eller M.S.... Gilchrest B.A. (Exp. Cell Res. 1992)
    7. Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. (PubMed id 7704533)1, 2, 9 Kleywegt G.J....Jones T.A. (Structure 1994)
    8. Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids. (PubMed id 10531482)1, 2, 9 Chaudhuri B.N.... Jones T.A. (Acta Crystallogr. D 1999)
    9. NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. (PubMed id 9737883)1, 2, 9 Wang L. and Yan H. (Biochemistry 1998)
    10. Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation. (PubMed id 21998312)1, 2 Majumdar A.... Noy N. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1382 HGNC: 2339 AceView: CRABP2 Ensembl:ENSG00000143320 euGenes: HUgn1382
    ECgene: CRABP2 H-InvDB: CRABP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRABP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRABP2 gene:
    Search GeneIP for patents involving CRABP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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