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Aliases for CRABP1 Gene

Aliases for CRABP1 Gene

  • Cellular Retinoic Acid Binding Protein 1 2 3 5
  • Cellular Retinoic Acid-Binding Protein I 3 4
  • CRABP-I 3 4
  • RBP5 3 4
  • Cellular Retinoic Acid-Binding Protein 1 2
  • CRABPI 3
  • CRABP 3

External Ids for CRABP1 Gene

Previous HGNC Symbols for CRABP1 Gene

  • RBP5

Previous GeneCards Identifiers for CRABP1 Gene

  • GC15P074711
  • GC15P071722
  • GC15P076208
  • GC15P076348
  • GC15P076419
  • GC15P078632
  • GC15P055390

Summaries for CRABP1 Gene

Entrez Gene Summary for CRABP1 Gene

  • This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRABP1 Gene

CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include Embryonal Carcinoma and Teratocarcinoma. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Signaling by Retinoic Acid. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for CRABP1 Gene

  • Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP1 Gene

Genomics for CRABP1 Gene

Regulatory Elements for CRABP1 Gene

Enhancers for CRABP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRABP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRABP1 Gene

Chromosome:
15
Start:
78,340,324 bp from pter
End:
78,348,230 bp from pter
Size:
7,907 bases
Orientation:
Plus strand

Genomic View for CRABP1 Gene

Genes around CRABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP1 Gene

Proteins for CRABP1 Gene

  • Protein details for CRABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29762-RABP1_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 1
    Protein Accession:
    P29762
    Secondary Accessions:
    • Q6IAY7
    • Q8WTV5

    Protein attributes for CRABP1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRABP1 Gene

Proteomics data for CRABP1 Gene at MOPED

Post-translational modifications for CRABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRABP1 Gene

Domains & Families for CRABP1 Gene

Gene Families for CRABP1 Gene

Suggested Antigen Peptide Sequences for CRABP1 Gene

Graphical View of Domain Structure for InterPro Entry

P29762

UniProtKB/Swiss-Prot:

RABP1_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP1: view

Function for CRABP1 Gene

Molecular function for CRABP1 Gene

GENATLAS Biochemistry:
retinoic acid binding protein,cellular I,(lipocalin family,kernel group)
UniProtKB/Swiss-Prot Function:
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Ontology (GO) - Molecular Function for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005515 protein binding IPI 15607035
GO:0008289 lipid binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with CRABP1: view
genes like me logo Genes that share phenotypes with CRABP1: view

Animal Models for CRABP1 Gene

MGI Knock Outs for CRABP1:

Animal Model Products

miRNA for CRABP1 Gene

miRTarBase miRNAs that target CRABP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP1 Gene

Localization for CRABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRABP1 Gene COMPARTMENTS Subcellular localization image for CRABP1 gene
Compartment Confidence
cytosol 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for CRABP1 Gene

Pathways & Interactions for CRABP1 Gene

genes like me logo Genes that share pathways with CRABP1: view

Pathways by source for CRABP1 Gene

1 BioSystems pathway for CRABP1 Gene
1 GeneGo (Thomson Reuters) pathway for CRABP1 Gene

Gene Ontology (GO) - Biological Process for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction TAS 1309505
genes like me logo Genes that share ontologies with CRABP1: view

No data available for SIGNOR curated interactions for CRABP1 Gene

Drugs & Compounds for CRABP1 Gene

(11) Drugs for CRABP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 215
Alitretinoin Approved, Investigational Pharma Carrier 15
N-(5,5,8,8-Tetramethyl-5,8-Dihydro-Naphthalen-2-Yl)-Terephthalamic Acid Experimental Pharma Carrier 0
Etretinate Withdrawn Pharma Carrier 0

(7) Additional Compounds for CRABP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRABP1: view

Transcripts for CRABP1 Gene

mRNA/cDNA for CRABP1 Gene

Unigene Clusters for CRABP1 Gene

Cellular retinoic acid binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP1 Gene

No ASD Table

Relevant External Links for CRABP1 Gene

GeneLoc Exon Structure for
CRABP1
ECgene alternative splicing isoforms for
CRABP1

Expression for CRABP1 Gene

mRNA expression in normal human tissues for CRABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP1 Gene

This gene is overexpressed in Thyroid (x7.3), Brain - Caudate (basal ganglia) (x6.1), Spleen (x5.8), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for CRABP1 Gene

This gene is overexpressed in Retina (46.6) and Cerebral cortex (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRABP1 Gene



SOURCE GeneReport for Unigene cluster for CRABP1 Gene Hs.346950

genes like me logo Genes that share expression patterns with CRABP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CRABP1 Gene

Orthologs for CRABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRABP1 35
  • 94.89 (n)
  • 99.27 (a)
CRABP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crabp1 35
  • 91.97 (n)
  • 99.27 (a)
Crabp1 16
Crabp1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRABP1 35
  • 100 (n)
  • 100 (a)
CRABP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crabp1 35
  • 93.67 (n)
  • 99.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CRABP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRABP1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRABP1 35
  • 83.7 (n)
  • 96.35 (a)
CRABP-I 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp1 35
  • 72.79 (n)
  • 84.56 (a)
zebrafish
(Danio rerio)
Actinopterygii crabp1 35
crabp1a 35
  • 77.21 (n)
  • 86.03 (a)
crabp1a 36
  • 72 (a)
OneToMany
crabp1b 36
  • 85 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2517 35
fruit fly
(Drosophila melanogaster)
Insecta fabp 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 35 (a)
ManyToMany
lbp-6 36
  • 39 (a)
ManyToMany
lbp-7 36
  • 36 (a)
ManyToMany
lbp-8 36
  • 32 (a)
ManyToMany
lbp-9 36
  • 28 (a)
ManyToMany
Species with no ortholog for CRABP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP1 Gene

ENSEMBL:
Gene Tree for CRABP1 (if available)
TreeFam:
Gene Tree for CRABP1 (if available)

Paralogs for CRABP1 Gene

Paralogs for CRABP1 Gene

(14) SIMAP similar genes for CRABP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRABP1: view

Variants for CRABP1 Gene

Sequence variations from dbSNP and Humsavar for CRABP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7164468 -- 78,347,035(+) TTCTA(A/C)CTGCC intron-variant
rs12442427 -- 78,341,553(+) AGGAG(A/G)AGGAG intron-variant
rs1127472 -- 78,340,488(+) CTGCT(C/G)AAGGC reference, synonymous-codon
rs12593362 -- 78,342,389(+) AAAAA(G/T)TAAAG intron-variant
rs12910273 -- 78,341,528(+) CAGCG(C/T)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP1 Gene

Variant ID Type Subtype PubMed ID
nsv833063 CNV Loss 17160897

Variation tolerance for CRABP1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRABP1 Gene

Disorders for CRABP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRABP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
moyamoya disease
  • moyamoya disease 3
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRABP1

Genetic Association Database (GAD)
CRABP1
Human Genome Epidemiology (HuGE) Navigator
CRABP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRABP1
genes like me logo Genes that share disorders with CRABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP1 Gene

Publications for CRABP1 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Astroem A. … Voorhees J.J. (J. Biol. Chem. 1991) 3 4 23 67
  2. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. (PMID: 9154115) Flagiello D. … Malfoy B. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. (PMID: 17438526) Tanaka K. … Inazawa J. (Oncogene 2007) 3 23
  4. Perinuclear localisation of cellular retinoic acid binding protein I mRNA. (PMID: 16376305) Levadoux-Martin M. … Hesketh J.E. (Biochem. Biophys. Res. Commun. 2006) 23 25
  5. Pathogenesis of bronchopulmonary dysplasia: the role of interleukin 1beta in the regulation of inflammation-mediated pulmonary retinoic acid pathways in transgenic mice. (PMID: 16813970) Bry K. … Lappalainen U. (Semin. Perinatol. 2006) 23 25

Products for CRABP1 Gene

Sources for CRABP1 Gene

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