Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRABP1 Gene

Aliases for CRABP1 Gene

  • Cellular Retinoic Acid Binding Protein 1 2 3 5
  • Cellular Retinoic Acid-Binding Protein 1 2 3
  • Cellular Retinoic Acid-Binding Protein I 3 4
  • CRABP-I 3 4
  • RBP5 3 4
  • CRABPI 3
  • CRABP 3

External Ids for CRABP1 Gene

Previous HGNC Symbols for CRABP1 Gene

  • RBP5

Previous GeneCards Identifiers for CRABP1 Gene

  • GC15P074711
  • GC15P071722
  • GC15P076208
  • GC15P076348
  • GC15P076419
  • GC15P078632
  • GC15P055390

Summaries for CRABP1 Gene

Entrez Gene Summary for CRABP1 Gene

  • This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRABP1 Gene

CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include Teratocarcinoma and Embryonal Carcinoma. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP2.

UniProtKB/Swiss-Prot for CRABP1 Gene

  • Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP1 Gene

Genomics for CRABP1 Gene

Regulatory Elements for CRABP1 Gene

Enhancers for CRABP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G078447 1.4 Ensembl ENCODE dbSUPER 10.2 +109.0 108980 3.6 HDAC1 HDGF PKNOX1 RB1 ZSCAN4 FEZF1 RAD21 YY1 SCRT2 ZNF143 CHRNA5 CRABP1 PSMA4 IREB2 ENSG00000259474
GH15G078453 1.4 Ensembl ENCODE dbSUPER 10 +115.1 115129 4.5 PKNOX1 CREB3L1 NFIB INSM2 SIN3A FEZF1 ZNF121 ZNF366 ZSCAN5C SCRT2 PSMA4 IREB2 WDR61 CRABP1 ENSG00000259474
GH15G078460 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +121.3 121337 1.4 HNF1A CEBPA HNF4A BCL6 CHRNA5 IREB2 WDR61 CRABP1 ACSBG1 ENSG00000259474
GH15G078305 1.2 Ensembl ENCODE 11 -33.9 -33860 2.1 HDAC1 HDGF PTBP1 TBL1XR1 ARNT NFRKB ZBTB40 CHAMP1 EGR1 ETV6 CRABP1 IREB2 HYKK WDR61 DNAJA4 GC15P078331
GH15G078315 1 Ensembl ENCODE 12.4 -23.8 -23839 2.2 BCOR CTCF NFRKB TSC22D4 MAX ZNF140 ZMYM3 RBBP5 BRCA1 ZIC2 CRABP1 IREB2 ACSBG1 CHRNA5 DNAJA4 GC15P078331 WDR61
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRABP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRABP1 Gene

78,340,324 bp from pter
78,348,230 bp from pter
7,907 bases
Plus strand

Genomic View for CRABP1 Gene

Genes around CRABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP1 Gene

Proteins for CRABP1 Gene

  • Protein details for CRABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cellular retinoic acid-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6IAY7
    • Q8WTV5

    Protein attributes for CRABP1 Gene

    137 amino acids
    Molecular mass:
    15566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRABP1 Gene

Post-translational modifications for CRABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRABP1 Gene

Domains & Families for CRABP1 Gene

Gene Families for CRABP1 Gene

Suggested Antigen Peptide Sequences for CRABP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP1: view

Function for CRABP1 Gene

Molecular function for CRABP1 Gene

GENATLAS Biochemistry:
retinoic acid binding protein,cellular I,(lipocalin family,kernel group)
UniProtKB/Swiss-Prot Function:
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Ontology (GO) - Molecular Function for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 1309505
GO:0005515 protein binding IPI 15607035
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with CRABP1: view
genes like me logo Genes that share phenotypes with CRABP1: view

Animal Models for CRABP1 Gene

MGI Knock Outs for CRABP1:

Animal Model Products

CRISPR Products

miRNA for CRABP1 Gene

miRTarBase miRNAs that target CRABP1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP1 Gene

Localization for CRABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRABP1 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRABP1: view

Pathways & Interactions for CRABP1 Gene

genes like me logo Genes that share pathways with CRABP1: view

Pathways by source for CRABP1 Gene

1 BioSystems pathway for CRABP1 Gene
1 GeneGo (Thomson Reuters) pathway for CRABP1 Gene

Interacting Proteins for CRABP1 Gene

Gene Ontology (GO) - Biological Process for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction TAS 1309505
GO:0007275 multicellular organism development TAS 1309505
GO:0034653 retinoic acid catabolic process IEA --
genes like me logo Genes that share ontologies with CRABP1: view

No data available for SIGNOR curated interactions for CRABP1 Gene

Drugs & Compounds for CRABP1 Gene

(12) Drugs for CRABP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alitretinoin Approved, Investigational Pharma Carrier 17
Tamibarotene Approved, Investigational Pharma Agonist, Carrier RARα agonist 0
Tretinoin Approved, Investigational Nutra Transporter, substrate 228
Etretinate Withdrawn Pharma Carrier 0

(7) Additional Compounds for CRABP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4
genes like me logo Genes that share compounds with CRABP1: view

Transcripts for CRABP1 Gene

mRNA/cDNA for CRABP1 Gene

Unigene Clusters for CRABP1 Gene

Cellular retinoic acid binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP1 Gene

No ASD Table

Relevant External Links for CRABP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRABP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP1 Gene

This gene is overexpressed in Thyroid (x7.3), Brain - Caudate (basal ganglia) (x6.1), Spleen (x5.8), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for CRABP1 Gene

This gene is overexpressed in Retina (46.6) and Cerebral cortex (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRABP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRABP1 Gene:


SOURCE GeneReport for Unigene cluster for CRABP1 Gene:


Evidence on tissue expression from TISSUES for CRABP1 Gene

  • Nervous system(4.6)
  • Eye(3)
  • Skin(2.6)
  • Thyroid gland(2.6)
genes like me logo Genes that share expression patterns with CRABP1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRABP1 Gene

Orthologs for CRABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRABP1 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia CRABP1 35
  • 96 (a)
(Bos Taurus)
Mammalia CRABP1 34 35
  • 94.89 (n)
(Rattus norvegicus)
Mammalia Crabp1 34
  • 93.67 (n)
(Mus musculus)
Mammalia Crabp1 34 16 35
  • 91.97 (n)
(Ornithorhynchus anatinus)
Mammalia CRABP1 35
  • 67 (a)
(Gallus gallus)
Aves CRABP-I 35
  • 96 (a)
  • 83.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp1 34
  • 72.79 (n)
(Danio rerio)
Actinopterygii crabp1b 35
  • 85 (a)
crabp1a 34 35
  • 77.21 (n)
crabp1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2517 34
fruit fly
(Drosophila melanogaster)
Insecta fabp 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea lbp-6 35
  • 39 (a)
lbp-7 35
  • 36 (a)
lbp-5 35
  • 35 (a)
lbp-8 35
  • 32 (a)
lbp-9 35
  • 28 (a)
Species where no ortholog for CRABP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP1 Gene

Gene Tree for CRABP1 (if available)
Gene Tree for CRABP1 (if available)

Paralogs for CRABP1 Gene

Paralogs for CRABP1 Gene

(14) SIMAP similar genes for CRABP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRABP1: view

Variants for CRABP1 Gene

Sequence variations from dbSNP and Humsavar for CRABP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000533445 -- 78,340,050(+) ACCCA(A/G)GTCCA upstream-variant-2KB
rs1000576819 -- 78,347,880(+) TTTTT(C/G)CACAG intron-variant
rs1000650487 -- 78,348,165(+) CCTAG(C/T)GCTCC utr-variant-3-prime
rs1000681553 -- 78,348,354(+) GCTTT(C/G)AGCAT downstream-variant-500B
rs1000811062 -- 78,342,169(+) AGGCA(A/C)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP1 Gene

Variant ID Type Subtype PubMed ID
nsv1052910 CNV gain 25217958
nsv1116464 OTHER inversion 24896259
nsv833063 CNV loss 17160897

Variation tolerance for CRABP1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRABP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRABP1 Gene

Disorders for CRABP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CRABP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • mixed embryonal carcinoma and teratoma
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
moyamoya disease
  • moyamoya disease 3
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRABP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP1 Gene

Publications for CRABP1 Gene

  1. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. (PMID: 9154115) Flagiello D. … Malfoy B. (Cytogenet. Cell Genet. 1997) 2 3 22 64
  2. The molecular cloning and expression of two CRABP cDNAs from human skin. (PMID: 1309505) Eller M.S. … Gilchrest B.A. (Exp. Cell Res. 1992) 3 4 22 64
  3. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Astroem A. … Voorhees J.J. (J. Biol. Chem. 1991) 3 4 22 64
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  5. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. (PMID: 17438526) Tanaka K. … Inazawa J. (Oncogene 2007) 3 22 64

Products for CRABP1 Gene

Sources for CRABP1 Gene

Loading form....