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CRABP1 Gene

protein-coding   GIFtS: 66
GCID: GC15P078632

Cellular Retinoic Acid Binding Protein 1

(Previous name: cellular retinoic acid-binding protein 1)
(Previous symbol: RBP5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cellular Retinoic Acid Binding Protein 11 2     CRABP-I2 3
RBP51 2 3 5     CRABP2
Cellular Retinoic Acid-Binding Protein 11 2     CRABPI2
Cellular Retinoic Acid-Binding Protein I2 3     

External Ids:    HGNC: 23381   Entrez Gene: 13812   Ensembl: ENSG000001664267   OMIM: 1802305   UniProtKB: P297623   

Export aliases for CRABP1 gene to outside databases

Previous GC identifers: GC15P074711 GC15P071722 GC15P076208 GC15P076348 GC15P076419 GC15P055390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRABP1 Gene:
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important
role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the
cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may
contribute to vitamin A-directed differentiation in epithelial tissue. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRABP1 Gene:
CRABP1 (cellular retinoic acid binding protein 1) is a protein-coding gene. Diseases associated with CRABP1 include moyamoya disease, and acute promyelocytic leukemia. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: RABP1_HUMAN, P29762
Function: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

Gene Wiki entry for CRABP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRABP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRABP1 promoter sequence
   Search Chromatin IP Primers for CRABP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRABP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24

CRABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRABP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078632:  view genomic region     (about GC identifiers)

Start:
78,632,666 bp from pter      End:
78,640,572 bp from pter
Size:
7,907 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RABP1_HUMAN, P29762 (See protein sequence)
Recommended Name: Cellular retinoic acid-binding protein 1  
Size: 137 amino acids; 15566 Da
Secondary accessions: Q6IAY7 Q8WTV5

Explore the universe of human proteins at neXtProt for CRABP1: NX_P29762

Explore proteomics data for CRABP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRABP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004369.1  
    ENSEMBL proteins: 
     ENSP00000299529   ENSP00000385978  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P29762

    ProtoNet protein and cluster: P29762

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: RABP1_HUMAN, P29762
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    CRABP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RABP1_HUMAN, P29762
    Function: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

         Genatlas biochemistry entry for CRABP1:
    retinoic acid binding protein,cellular I,(lipocalin family,kernel group)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IEA--
    GO:0005215transporter activity IEA--
    GO:0005501retinoid binding TAS1309505
    GO:0005515protein binding IPI15607035
    GO:0016918retinal binding IEA--
         
    CRABP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRABP1:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crabp1):
     hearing/vestibular/ear  limbs/digits/tail  mortality/aging  normal 

    CRABP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRABP1: Crabp1tm1Ipc Crabp1tm1Adg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRABP1
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    miRTarBase miRNAs that target CRABP1:
    hsa-mir-335-5p (MIRT018173)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RABP1_HUMAN, P29762: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    CRABP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRABP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism
    2Retinol metabolism
    Retinol metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRABP1
        Nuclear Receptor Activation by Vitamin-A
    all-trans-Retinoic Acid Signaling in Brain
    Visual Cycle in Retinal Rods
    all-trans-Retinoic Acid Mediated Apoptosis
    RAR-Gamma-RXR-Alpha Degradation

    1 GeneGo (Thomson Reuters) Pathway for CRABP1
        Retinol metabolism

    1 BioSystems Pathway for CRABP1
        Vitamin A and carotenoid metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRABP1
    Interactions:

        GeneGlobe Interaction Network for CRABP1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CRABP1 (P297622, 3 ENSP000002995294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682, 3MINT-64782 I2D: score=4 
    TRA2AQ135952, 3, ENSP000002970714MINT-8252648 I2D: score=2 STRING: ENSP00000297071
    ACDENSP000003774964STRING: ENSP00000377496
    INADLENSP000003602004STRING: ENSP00000360200
    DLG3ENSP000003634804STRING: ENSP00000363480
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS1309505
    GO:0007275multicellular organismal development TAS1309505

    CRABP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRABP1 (RABP1)

    1 HMDB Compound for CRABP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinoic acidRetinoate (see all 21)302-79-4--

    4 DrugBank Compounds for CRABP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8carrier--16215318 16109390 16376305 16788631 16813970
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4transportersubstrate16109390 20552429
    Etretinate-- 54350-48-0carrier--3017242
    N-(5,5,8,8-Tetramethyl-5,8-Dihydro-Naphthalen-2-Yl)-Terephthalamic Acid-- --carrier--10592235

    Selected Novoseek inferred chemical compound relationships for CRABP1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ch 55 91.3 5 9269772 (1), 9720716 (1), 10704935 (1), 9701451 (1)
    retinoic acid 90.9 486 14713576 (8), 1847931 (7), 8382035 (7), 10446126 (6) (see all 99)
    retinoid 85.9 31 7586162 (2), 10571207 (2), 8382035 (2), 15130509 (1) (see all 23)
    am80 81 3 9269772 (1), 9720716 (1), 10531482 (1)
    vitamin a 75.4 35 2163611 (2), 11288179 (1), 11956581 (1), 7586162 (1) (see all 22)
    4-oxoretinoic acid 69.1 1 8144640 (1)
    acitretin 49.4 1 15714209 (1)
    indinavir 24.1 3 10704935 (1), 12844477 (1)
    isotretinoin 22.1 2 10202838 (1), 10571207 (1)
    fatty acid 7.05 3 15063719 (1), 9741849 (1)



    CRABP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRABP1 gene: 
    NM_004378.2  

    Unigene Cluster for CRABP1:

    Cellular retinoic acid binding protein 1
    Hs.346950  [show with all ESTs]
    Unigene Representative Sequence: AK096006
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299529(uc002bdp.2) ENST00000406419 ENST00000560753
    miRNA
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    Additional mRNA sequence: 

    AB593091.1 AK096006.1 AL110113.1 BC022069.1 CR457017.1 S74445.1 

    5 DOTS entries:

    DT.455548  DT.99933240  DT.100810081  DT.102825560  DT.95268034 

    Selected AceView cDNA sequences (see all 85):

    AI802302 AI863257 AA421217 BM668429 CA336112 AI668887 BQ638094 C20778 
    BM679148 CA389146 AU154201 AA326942 BU558224 BM699470 BM705057 BQ277632 
    BQ636048 BM711776 BV207813 AI376413 BM704011 CR457017 AW029383 BM722659 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRABP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAATGTTGT
    CRABP1 Expression
    About this image


    CRABP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Roof Plate Cells Mesencephalic Roof Plate
             Mesencephalic Roof Plate
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Branchial Arch 1
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
    CRABP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRABP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.346950
        Custom PCR Arrays for CRABP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRABP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRABP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crabp11 , 5 cellular retinoic acid binding protein I1, 5 91.97(n)1
    99.27(a)1
      9 (29.76 cM)5
    129031  NM_013496.31  NP_038524.11 
     547647485 
    chicken
    (Gallus gallus)
    Aves CRABP11 cellular retinoic acid binding protein 1 83.7(n)
    96.35(a)
      374211  NM_001030539.1  NP_001025710.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crabp11 cellular retinoic acid binding protein 1 72.79(n)
    84.56(a)
      100496464  XM_002934567.2  XP_002934613.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crabp12 cellular retinoic acid binding protein 1 79.09(n)   171479  AY242125.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fabp6
    fatty acid bindin protein
    31(a)
    1 → many
    3R(7385612-7392771)
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-66
    lbp-76
    (see all 5)
    Protein LBP-7 (lbp-7) mRNA, complete cds
    (see all 5)
    39(a)
    36(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(6728285-6729376) WBGene00002258
    V(13879550-13880214) WBGene00002259


    ENSEMBL Gene Tree for CRABP1 (if available)
    TreeFam Gene Tree for CRABP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRABP1 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP12  
    RBP22  FABP22  PMP22  FABP72  RBP72  
    14 SIMAP similar genes for CRABP1 using alignment to 3 protein entries:     RABP1_HUMAN (see all proteins):
    CRABP2    DKFZp547J2313    FABP7    RBP5    FABP3    RBP1
    PMP2    RBP2    RBP7    FABP12    FABP5    FABP9
    FABP2    FABP4

    CRABP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRABP1 (see all 235)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877306411,2
    --78630673(+) GGCAGC/TTCCAT 1 -- us2k10--------
    rs1499612501,2
    --78630745(+) TTCAGG/TACTCC 1 -- us2k10--------
    rs1921739131,2
    C--78630939(+) CCCAGC/TTACTT 1 -- us2k10--------
    rs1122873841,2
    C,F--78631009(+) ATTGCG/ACCACT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs38135731,2
    C,F,A,H--78631359(-) CTTGGG/AGAATC 1 -- us2k121Minor allele frequency- A:0.18NS EA NA WA 2488
    rs734575531,2
    C,F--78631377(+) GGGAAT/CCTTCA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1844344241,2
    --78631512(+) CAGAGC/TGAAGA 1 -- us2k10--------
    rs1872411681,2
    --78631716(+) TAAAAC/TGCATG 1 -- us2k10--------
    rs1927789011,2
    --78631824(+) CAAGGG/TTAATA 1 -- us2k10--------
    rs1113587501,2
    F--78632074(+) CTGCAC/GTCGGA 1 -- us2k12Minor allele frequency- G:0.02CSA WA 119

    HapMap Linkage Disequilibrium report for CRABP1 (78632666 - 78640572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRABP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833063CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRABP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRABP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180230    OMIM disorders: --

    Selected diseases for CRABP1 (see all 41):    
    About MalaCards
    moyamoya disease    acute promyelocytic leukemia    teratocarcinoma    keratoacanthoma
    lipodystrophy    bronchopulmonary dysplasia    functioning pituitary adenoma    t cell deficiency
    papillary thyroid carcinoma    cervical intraepithelial neoplasia    neural tube defects    pituitary adenoma
    basal cell carcinoma    leiomyoma    oral squamous cell carcinoma    adenoma
    esophageal squamous cell carcinoma    rhabdomyosarcoma    squamous cell carcinoma    acute leukemia

    1 disease from the University of Copenhagen DISEASES database for CRABP1:
    Colorectal cancer

    CRABP1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CRABP1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 63.4 3 1648546 (1), 8207983 (1), 7815831 (1)
    teratocarcinoma 50.2 4 1328234 (2), 1847931 (1)
    lipodystrophy 46 3 10202838 (1), 12844477 (1), 10860898 (1)
    carcinoma embryonal 40.7 2 15130509 (1)
    cervix uteri 34.3 3 10641750 (2), 1329518 (1)
    carcinoma squamous cell 30.1 6 15281009 (2), 1335015 (1), 1329518 (1), 7798615 (1)
    squamous cell cancer 25.6 1 1329518 (1)
    psoriasis 14.4 1 1335801 (1)
    carcinoma renal cell 0.271 1 16254461 (1)
    colorectal carcinoma 0 1 9200956 (1)

    Genetic Association Database (GAD): CRABP1
    Human Genome Epidemiology (HuGE) Navigator: CRABP1 (7 documents)

    Export disorders for CRABP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRABP1 gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with CRABP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PubMed id 1654334)1, 2, 9 Astroem A....Voorhees J.J. (J. Biol. Chem. 1991)
    2. The molecular cloning and expression of two CRABP cDNAs from human skin. (PubMed id 1309505)1, 2, 9 Eller M.S.... Gilchrest B.A. (Exp. Cell Res. 1992)
    3. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. (PubMed id 9154115)1, 3, 9 Flagiello D....Malfoy B. (Cytogenet. Cell Genet. 1997)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation. (PubMed id 14713576)1, 9 Blaese M.A....Rodemann H.P. (Int. J. Radiat. Biol. 2003)
    7. Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma. (PubMed id 16254461)1, 9 Pfoertner S....Schrader A.J. (Tumour Biol. 2005)
    8. Perinuclear localisation of cellular retinoic acid binding protein I mRNA. (PubMed id 16376305)7, 9 Levadoux-Martin M....Hesketh J.E. (Biochem. Biophys. Res. Commun. 2006)
    9. The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma. (PubMed id 15281009)1, 9 Won J.Y....Kim S.Y. (Metab. Clin. Exp. 2004)
    10. Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease. (PubMed id 14605320)1, 9 Kim S.K....Wang K.C. ( a journal of cerebral circulation 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1381 HGNC: 2338 AceView: CRABP1 Ensembl:ENSG00000166426 euGenes: HUgn1381
    ECgene: CRABP1 H-InvDB: CRABP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRABP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRABP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRABP1 gene:
    Search GeneIP for patents involving CRABP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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