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Aliases for CRABP1 Gene

Aliases for CRABP1 Gene

  • Cellular Retinoic Acid Binding Protein 1 2 3
  • RBP5 3 4 6
  • Cellular Retinoic Acid-Binding Protein 1 2 3
  • Cellular Retinoic Acid-Binding Protein I 3 4
  • CRABP-I 3 4
  • CRABPI 3
  • CRABP 3

External Ids for CRABP1 Gene

Previous Symbols for CRABP1 Gene

  • RBP5

Summaries for CRABP1 Gene

Entrez Gene Summary for CRABP1 Gene

  • This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRABP1 Gene

CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include colorectal cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Visual Cycle in Retinal Rods. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for CRABP1 Gene

  • Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

Gene Wiki entry for CRABP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP1 Gene

Genomics for CRABP1 Gene

Genomic Location for CRABP1 Gene

Start:
78,340,324 bp from pter
End:
78,348,230 bp from pter
Size:
7,907 bases
Orientation:
Plus strand

Genomic View for CRABP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP1 Gene

Regulatory Elements for CRABP1 Gene

Proteins for CRABP1 Gene

  • Protein details for CRABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29762-RABP1_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 1
    Protein Accession:
    P29762
    Secondary Accessions:
    • Q6IAY7
    • Q8WTV5

    Protein attributes for CRABP1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRABP1 Gene

Proteomics data for CRABP1 Gene at MOPED

Post-translational modifications for CRABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRABP1 Gene

Domains for CRABP1 Gene

Gene Families for CRABP1 Gene

HGNC:
  • FABP :Fatty acid binding protein family

UniProtKB/Swiss-Prot:

RABP1_HUMAN
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.:
    • P29762
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.:
    • P29762
genes like me logo Genes that share domains with CRABP1: view

Function for CRABP1 Gene

Molecular function for CRABP1 Gene

GENATLAS Biochemistry: retinoic acid binding protein,cellular I,(lipocalin family,kernel group)
UniProtKB/Swiss-Prot Function: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

Gene Ontology (GO) - Molecular Function for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 1309505
GO:0005515 protein binding IPI 15607035
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with CRABP1: view

Phenotypes for CRABP1 Gene

genes like me logo Genes that share phenotypes with CRABP1: view

Animal Models for CRABP1 Gene

MGI Knock Outs for CRABP1:

miRNA for CRABP1 Gene

miRTarBase miRNAs that target CRABP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRABP1 Gene

Localization for CRABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRABP1 Gene COMPARTMENTS Subcellular localization image for CRABP1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRABP1: view

Pathways for CRABP1 Gene

genes like me logo Genes that share pathways with CRABP1: view

Gene Ontology (GO) - Biological Process for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction TAS 1309505
GO:0007275 multicellular organismal development TAS 1309505
genes like me logo Genes that share ontologies with CRABP1: view

Compounds for CRABP1 Gene

(1) HMDB Compounds for CRABP1 Gene

Compound Synonyms Cas Number PubMed IDs
Retinoic acid
  • Retinoate
302-79-4

(4) Drugbank Compounds for CRABP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alitretinoin
  • 9-cis-Retinoic acid
5300-03-8 carrier
Etretinate
54350-48-0 carrier
N-(5,5,8,8-Tetramethyl-5,8-Dihydro-Naphthalen-2-Yl)-Terephthalamic Acid
carrier
Tretinoin
  • All Trans Retinoic Acid
302-79-4 transporter substrate

(14) Novoseek inferred chemical compound relationships for CRABP1 Gene

Compound -log(P) Hits PubMed IDs
ch 55 91.3 4
retinoic acid 90.9 208
retinoid 85.9 26
am80 81 3
vitamin a 75.4 23
genes like me logo Genes that share compounds with CRABP1: view

Transcripts for CRABP1 Gene

mRNA/cDNA for CRABP1 Gene

Unigene Clusters for CRABP1 Gene

Cellular retinoic acid binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP1 Gene

No ASD Table

Relevant External Links for CRABP1 Gene

GeneLoc Exon Structure for
CRABP1
ECgene alternative splicing isoforms for
CRABP1

Expression for CRABP1 Gene

mRNA expression in normal human tissues for CRABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP1 Gene

This gene is overexpressed in Thyroid (7.3), Brain - Caudate (basal ganglia) (6.1), Spleen (5.8), Brain - Nucleus accumbens (basal ganglia) (5.2), Brain - Putamen (basal ganglia) (4.9), and Brain - Hypothalamus (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRABP1 Gene

SOURCE GeneReport for Unigene cluster for CRABP1 Gene Hs.346950

genes like me logo Genes that share expressions with CRABP1: view

Orthologs for CRABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRABP1 36
  • 100 (n)
  • 100 (a)
CRABP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRABP1 36
  • 94.89 (n)
  • 99.27 (a)
CRABP1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crabp1 36
  • 91.97 (n)
  • 99.27 (a)
Crabp1 16
Crabp1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRABP1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRABP1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crabp1 36
  • 93.67 (n)
  • 99.27 (a)
chicken
(Gallus gallus)
Aves CRABP-I 37
  • 96 (a)
OneToOne
CRABP1 36
  • 83.7 (n)
  • 96.35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp1 36
  • 72.79 (n)
  • 84.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2517 36
zebrafish
(Danio rerio)
Actinopterygii crabp1 36
crabp1a 36
  • 77.21 (n)
  • 86.03 (a)
crabp1a 37
  • 72 (a)
OneToMany
crabp1b 37
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fabp 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 37
  • 35 (a)
ManyToMany
lbp-6 37
  • 39 (a)
ManyToMany
lbp-7 37
  • 36 (a)
ManyToMany
lbp-8 37
  • 32 (a)
ManyToMany
lbp-9 37
  • 28 (a)
ManyToMany
Species with no ortholog for CRABP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP1 Gene

ENSEMBL:
Gene Tree for CRABP1 (if available)
TreeFam:
Gene Tree for CRABP1 (if available)

Paralogs for CRABP1 Gene

Paralogs for CRABP1 Gene

Selected SIMAP similar genes for CRABP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRABP1: view

Variants for CRABP1 Gene

Sequence variations from dbSNP and Humsavar for CRABP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1127472 -- 78,340,488(+) CTGCT(C/G)AAGGC reference, synonymous-codon
rs2139440 -- 78,341,253(-) GGGAC(A/C)CGGGG intron-variant
rs2280367 -- 78,340,165(-) TGGGG(A/G)GCCTC upstream-variant-2KB
rs2280368 -- 78,340,032(-) CTACT(C/T)TTCTC upstream-variant-2KB
rs3784333 -- 78,342,846(-) GATTT(A/G)ACAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP1 Gene

Variant ID Type Subtype PubMed ID
nsv833063 CNV Loss 17160897

Relevant External Links for CRABP1 Gene

HapMap Linkage Disequilibrium report
CRABP1

Disorders for CRABP1 Gene

(1) MalaCards Diseases for CRABP1 Gene

Search for CRABP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CRABP1 Gene

(15) Novoseek inferred disease relationships for CRABP1 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 63.4 3
teratocarcinoma 50.2 3
lipodystrophy 46 3
carcinoma embryonal 40.7 1
cervix uteri 34.3 3

Relevant External Links for CRABP1

Genetic Association Database (GAD)
CRABP1
Human Genome Epidemiology (HuGE) Navigator
CRABP1
genes like me logo Genes that share disorders with CRABP1: view

No data available for UniProtKB/Swiss-Prot for CRABP1 Gene

Publications for CRABP1 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Astroem A. … Voorhees J.J. (J. Biol. Chem. 1991) 3 4 23
  2. The molecular cloning and expression of two CRABP cDNAs from human skin. (PMID: 1309505) Eller M.S. … Gilchrest B.A. (Exp. Cell Res. 1992) 3 4 23
  3. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. (PMID: 9154115) Flagiello D. … Malfoy B. (Cytogenet. Cell Genet. 1997) 2 3 23
  4. Regulation of cellular retinoic acid binding protein (CRABP II) during human monocyte differentiation in vitro. (PMID: 9704013) Kreutz M. … Krause S.W. (Biochem. Biophys. Res. Commun. 1998) 3 23
  5. Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutants. (PMID: 8999826) Wang L. … Yan H. (J. Biol. Chem. 1997) 3 23

Products for CRABP1 Gene

  • antibodies-online proteins for CRABP1
  • antibodies-online antibodies for CRABP1
  • antibodies-online kits for CRABP1

Sources for CRABP1 Gene

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