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CR2 Gene

protein-coding   GIFtS: 65
GCID: GC01P207627

Complement Component (3d/Epstein Barr Virus) Receptor 2

  See CR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component (3d/Epstein Barr Virus) Receptor 21 2     SLEB92 5
C3DR2 3 5     CD212
Complement C3d Receptor2 3     CR2
Epstein-Barr Virus Receptor2 3     Complement Receptor Type 22
EBV Receptor2 3     Cr23
CVID72 5     CD21 Antigen3

External Ids:    HGNC: 23361   Entrez Gene: 13802   Ensembl: ENSG000001173227   OMIM: 1206505   UniProtKB: P200233   

Export aliases for CR2 gene to outside databases

Previous GC identifers: GC01P206287 GC01P203337 GC01P204270 GC01P204578 GC01P204016 GC01P205694 GC01P178320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CR2 Gene:
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and
T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus
type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this
gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for CR2 Gene:
CR2 (complement component (3d/Epstein Barr virus) receptor 2) is a protein-coding gene. Diseases associated with CR2 include chronic wasting disease, and follicular dendritic cell tumor. GO annotations related to this gene include protein homodimerization activity and complement receptor activity. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: CR2_HUMAN, P20023
Function: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU.
Participates in B lymphocytes activation

Gene Wiki entry for CR2 (Complement receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CR2 gene promoter:
         GR   AML1a   Pax-6   GR-beta   FOXD1   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCR2 promoter sequence
   Search Chromatin IP Primers for CR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

CR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207627:  view genomic region     (about GC identifiers)

Start:
207,627,575 bp from pter      End:
207,663,240 bp from pter
Size:
35,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CR2_HUMAN, P20023 (See protein sequence)
Recommended Name: Complement receptor type 2 precursor  
Size: 1033 amino acids; 112916 Da
Subunit: Interacts (via Sushi domain 1 and 2) with C3dg
Sequence caution: Sequence=AAA35784.1; Type=Frameshift; Positions=758, 769, 776;
6 PDB 3D structures from and Proteopedia for CR2:
1GHQ (3D)        1LY2 (3D)        1W2R (3D)        1W2S (3D)        2GSX (3D)        3OED (3D)    
Secondary accessions: C9JHD2 Q13866 Q14212 Q53EL2 Q5BKT9 Q5SR46 Q5SR48
Alternative splicing: 4 isoforms:  P20023-1   P20023-2   P20023-3   P20023-4   (Ref.3 (AAA35784) sequence is in conflict in position: 663:S->P)

Explore the universe of human proteins at neXtProt for CR2: NX_P20023

Explore proteomics data for CR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn121, Asn127, Asn294, Asn372, Asn492, Asn623, Asn682, Asn800, Asn823, Asn861,
                                 Asn911
  • Modification sites at PhosphoSitePlus

  • See CR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006659.1  NP_001868.2  

    ENSEMBL proteins: 
     ENSP00000356025   ENSP00000356024   ENSP00000356026   ENSP00000404222  

    CR2 Human Recombinant Protein Products:

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    antibodies-online proteins for CR2 

     
    antibodies-online peptides for CR2

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    antibodies-online antibodies for CR2 (248 products) 

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    antibodies-online kits for CR2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    complement: Complement system

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P20023

    ProtoNet protein and cluster: P20023

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: CR2_HUMAN, P20023
    Similarity: Belongs to the receptors of complement activation (RCA) family
    Similarity: Contains 15 Sushi (CCP/SCR) domains


    Find genes that share domains with CR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR2_HUMAN, P20023
    Function: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU.
    Participates in B lymphocytes activation

         Genatlas biochemistry entry for CR2:
    complement component (C3d/Epstein Barr virus) receptor 2 (see RCA@)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001848complement binding IDA11034390
    GO:0003677DNA binding IDA--
    GO:0004872receptor activity ----
    GO:0004875complement receptor activity NAS2827171
    GO:0004888transmembrane signaling receptor activity NAS2827171
         
    Find genes that share ontologies with CR2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cr2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  renal/urinary system 

    Find genes that share phenotypes with CR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CR2: Cr2tm1Tft Cr2tm1Crr Cr2tm2.1Jhws Cr2tm1.1Jhws Cr2tm1Hmo

       genOway: Develop your customized and physiologically relevant rodent model for CR2

    miRNA
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    miRTarBase miRNAs that target CR2:
    hsa-mir-132-3p (MIRT021795)

    Block miRNA regulation of human, mouse, rat CR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CR2 (see all 13):
    hsa-miR-34c-5p hsa-miR-3688-3p hsa-miR-449b hsa-miR-4297 hsa-miR-519e hsa-miR-519c-3p hsa-miR-449a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CR2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CR2 (NM_001006658)
    Sino Biological Human cDNA Clone for CR2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CR2_HUMAN, P20023: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS2563370
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane NAS2827171
    GO:0043235receptor complex IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with CR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CR2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Immune response Alternative complement pathway0.56
    Immune response Classic complement pathway0.56
    Complement Activation Pathways0.30
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    34-1BB Pathway
    NF-KappaB Activation by EBV0.42
    NF-kappaB Activation by Viruses0.42
    4Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    5B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42


    Find genes that share SuperPaths with CR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CR2
        PI3K Signaling in B-Lymphocyte
    NF-kappaB Activation by Viruses
    NF-KappaB Activation by EBV

    5 GeneGo (Thomson Reuters) Pathways for CR2
        Immune response Alternative complement pathway
    Apoptosis and survival APRIL and BAFF signaling
    Immune response Classical complement pathway
    Immune response BCR pathway
    Immune response Lectin induced complement pathway

    2 BioSystems Pathways for CR2
        B Cell Receptor Signaling Pathway
    Complement and Coagulation Cascades

    1 Sino Biological Pathway for CR2
        Complement Activation Pathways


    4 Kegg Pathways  (Kegg details for CR2):
        Complement and coagulation cascades
    Hematopoietic cell lineage
    B cell receptor signaling pathway
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CR2: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CR2 (P200233 ENSP000003560244) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNA1P015623, ENSP000002769274I2D: score=3 STRING: ENSP00000276927
    C3P010243, ENSP000002459074I2D: score=3 STRING: ENSP00000245907
    CD19P153913, ENSP000003134194I2D: score=3 STRING: ENSP00000313419
    IFITM1P131643, ENSP000003861874I2D: score=3 STRING: ENSP00000386187
    IFNA13P015623I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002430complement receptor mediated signaling pathway ----
    GO:0006955immune response NAS2827171
    GO:0006958complement activation, classical pathway IEA--
    GO:0030183B cell differentiation IDA2995485
    GO:0042100B cell proliferation IDA2995485

    Find genes that share ontologies with CR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CR2

    Selected Novoseek inferred chemical compound relationships for CR2 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cr2+ 70.8 6 9886379 (2), 1378022 (1), 7957570 (1)
    paraffin 17.7 4 9521469 (1), 8607441 (1), 9820867 (1), 18813826 (1)
    tyrosine 15.7 26 9886379 (5), 11207269 (5), 16289966 (4), 9808169 (1) (see all 10)
    okt3 14.5 1 1371493 (1)
    streptavidin 5.83 2 15713467 (1), 11684127 (1)
    hematoxylin 0 1 7706516 (1)
    calcium 0 6 1831222 (2), 2137840 (1), 1371493 (1), 1386093 (1)
    threonine 0 1 9250823 (1)
    zinc 0 1 7759994 (1)
    phosphatidylinositol 0 4 9886379 (2), 7688513 (1)



    Find genes that share compounds with CR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CR2 gene (2 alternative transcripts): 
    NM_001006658.2  NM_001877.4  

    Unigene Cluster for CR2:

    Complement component (3d/Epstein Barr virus) receptor 2
    Hs.445757  [show with all ESTs]
    Unigene Representative Sequence: NM_001006658
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367058(uc001hfw.3) ENST00000367057(uc001hfv.3) ENST00000367059(uc009xci.1 uc009xch.3)
    ENST00000479186 ENST00000485707 ENST00000475194 ENST00000458541
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    hsa-miR-34c-5p hsa-miR-3688-3p hsa-miR-449b hsa-miR-4297 hsa-miR-519e hsa-miR-519c-3p hsa-miR-449a hsa-miR-519a
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    Additional mRNA sequence: 

    AK223627.1 AK301496.1 BC032548.1 BC090937.1 BC136394.1 J03565.1 M26004.1 M26317.1 
    S62696.1 Y00649.1 

    8 DOTS entries:

    DT.114560  DT.100746166  DT.101980265  DT.114562  DT.101959379  DT.86845818  DT.101969390  DT.121335820 

    Selected AceView cDNA sequences (see all 97):

    S62696 BU429544 AI253682 X68990 CF137827 AW303499 AW317053 NM_001877 
    BP338927 AI880641 AU133057 BU430697 AI819443 AI635781 AW951599 AA744360 
    AI015545 AW503883 CF121681 AA808943 AI934444 M26004 BQ004295 AI695225 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CR2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:        -     -                                                                                                                                             
    SP4:                                                                                      -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTAAAAA
    CR2 Expression
    About this image


    CR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    CR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445757

    UniProtKB/Swiss-Prot: CR2_HUMAN, P20023
    Tissue specificity: Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular
    dendritic cells of the spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CR2: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cr21 , 5 complement receptor 21, 5 76.64(n)1
    66.28(a)1
      1 (98.44 cM)5
    129021  NM_007758.21  NP_031784.11 
     1951368115 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    GL343255.1(1970429-1983402)
    zebrafish
    (Danio rerio)
    Actinopterygii selp6
    --
    10(a)
    many ↔ many
    20(33987436-33990756) ENSDARG00000096787
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101866
    --
    13(a)
    many ↔ many
    2L(19508953-19517201)


    ENSEMBL Gene Tree for CR2 (if available)
    TreeFam Gene Tree for CR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CR2 gene
    CSMD12  SELP2  C4BPA2  SELL2  CSMD32  CR1L2  APOH2  CSMD22  
    SELE2  CD462  CD552  CR12  SVEP12  
    3 SIMAP similar genes for CR2 using alignment to 4 protein entries:     CR2_HUMAN (see all proteins):
    cd21    CR1    CD55

    Find genes that share paralogs with CR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CR2 (see all 867)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124976781,2
    C--207631404(+) CCACA-/C/C   
      ACACAC
    ACACA
    2 -- int11CSA 2
    rs597356421,2
    C--207631444(+) CACAC-/ACACAC/ACACAC
    AC
    /ACACACACACAC
    TCCTT
    6 -- int1 cds11NA 2
    rs351625051,2
    C--207631623(+) TTTTT-/TGGCCC 2 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs717557181,2
    C--207638754(+) CATAC-/AT/TA 
            
    ATATA
    2 -- int10--------
    rs349565111,2
    C--207638767(+) ATATA-/TAATTAT 2 -- int11Minor allele frequency- TA:0.00NA 2
    rs730725771,2
    C,F--207650615(+) AGAGAG/ACGTGT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1435410321,2
    C--207652232(+) AAAAA-/AGGCCA 2 -- int10--------
    rs570324781,2
    C--207654266(+) AAAAA-/ATTGTG 2 -- int10--------
    rs354264731,2
    C--207656900(+) TTTTTT/-CTTGT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs672079601,2
    C--207659917(-) TCTTA-/AC/C  
            
    ACAGC
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for CR2 (207627575 - 207663240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv174e1CNV Complex17122850
    dgv175e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120650   
    OMIM disorders: 610927  614699  
    UniProtKB/Swiss-Prot: CR2_HUMAN, P20023
  • Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often
    febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin,
    joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the
    regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an
    elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by
    antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody
    response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of
    immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 19 diseases for CR2:    
    About MalaCards
    chronic wasting disease    follicular dendritic cell tumor    systemic lupus erythematosus 9    immunodeficiency, common variable, 7
    smooth muscle tumor    cr2-related common variable immune deficiency    cr2-related susceptibility to systemic lupus erythematosus    histiocytic sarcoma
    follicular dendritic cell sarcoma    dendritic cell sarcoma    common variable immune deficiency    immunodeficiency, common variable, 9
    lupus erythematosus    castleman's disease    prion disease    infectious mononucleosis
    stickler syndrome    systemic lupus erythematosus    inflammatory myofibroblastic tumor


    Find genes that share disorders with CR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CR2 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ebv infections 80.5 15 9344904 (2), 10233927 (1), 1966579 (1), 1712014 (1) (see all 11)
    lymphoma 52.2 11 8547075 (2), 15944952 (1), 16054780 (1), 16289966 (1) (see all 7)
    burkitt lymphoma 49.9 3 1283697 (1), 1354347 (1)
    infectious mononucleosis 46 3 1315687 (1), 8210710 (1)
    smooth muscle tumor 43 1 9198329 (1)
    lymphoma b-cell 38.4 6 9521469 (1), 15521918 (1), 9250823 (1), 20009432 (1) (see all 5)
    herpes 36.6 1 18813826 (1)
    sarcoma 36.1 1 8001974 (1)
    lupus erythematosus systemic 32.7 4 1424280 (1), 19387458 (1), 15932028 (1), 14719374 (1)
    leukaemia lymphocytic 30.6 2 9250823 (1), 1825940 (1)

    Genatlas disease: CR2
    infections,recurrent,pyogenic

    Genetic Association Database (GAD): CR2
    Human Genome Epidemiology (HuGE) Navigator: CR2 (11 documents)

    Export disorders for CR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CR2 gene, integrated from 10 sources (see all 327):
    (articles sorted by number of sources associating them with CR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. (PubMed id 17360460)1, 2, 4 Wu H.... Tsao B.P. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    2. Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage. (PubMed id 10068037)1, 2, 9 Barel M.... Frade R. (Mol. Immunol. 1998)
    3. The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding. (PubMed id 12122212)1, 2, 9 Prota A.E.... Fingeroth J.D. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. (PubMed id 19387458)1, 4, 9 Douglas K.B....Boackle S.A. (Genes Immun. 2009)
    5. A crystal structure of the complex between human complement receptor 2 and its ligand C3d. (PubMed id 21527715)1, 2 van den Elsen J.M. and Isenman D.E. (Science 2011)
    6. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PubMed id 21490949)1, 4 Sim X....Tai E.S. (PLoS Genet. 2011)
    7. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    8. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (Lancet 2008)
    9. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    10. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (Hum. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1380 HGNC: 2336 AceView: CR2 Ensembl:ENSG00000117322 euGenes: HUgn1380
    ECgene: CR2 Kegg: 1380 H-InvDB: CR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CR2 gene:
    Search GeneIP for patents involving CR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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