CR1L Gene
protein-coding GIFtS: 43
GCID: GC01P207820
|
|
complement component (3b/4b) receptor 1-like
| |
Aliases
for CR1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Component (3b/4b) Receptor 1-Like1 2 | | Complement C4b-Binding Protein CR-1-Like Protein2 3 | | Complement Component Receptor 1-Like Protein2 |
Export aliases for CR1L gene to outside databasesPrevious GC identifers: GC01P206492 GC01P203528 GC01P204461 GC01P204579 GC01P204581 GC01P204206 GC01P205885 GC01P178493 |
Summaries
for CR1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CR1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CR1L gene promoter:
Spz1 Sox5 MEF-2 HNF-3beta MEF-2A FOXO1a aMEF-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CR1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CR1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.1CR1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P207820: view genomic region
(about GC identifiers)
Start:
|
207,818,458 bp from pter |
End:
|
207,911,761 bp from pter |
Size:
|
93,304 bases |
Orientation:
|
plus strand |
|
Proteins
for CR1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CR1L_HUMAN, Q2VPA4 (See
protein sequence)Recommended Name: Complement component receptor 1-like protein precursor Size: 569 amino acids; 62714 Da
Subunit: Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3)
Subcellular location: Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membranefraction, but also located in the cytoplasm and in the supernatant
Secondary accessions: Q32MC9 Q8NEU7Alternative splicing: 3 isoforms: Q2VPA4-1 Q2VPA4-2 Q2VPA4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CR1L: NX_Q2VPA4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2VPA4
CR1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_783641.1
ENSEMBL proteins: ENSP00000421736 ENSP00000434864
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CR1L for ontologies About GeneDecksing
CR1L Antibody Products:
Assay Products for CR1L: |
Protein
Domains /
Families
for CR1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CR1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2VPA4ProtoNet protein and cluster: Q2VPA4 UniProtKB/Swiss-Prot: CR1L_HUMAN, Q2VPA4Similarity: Belongs to the receptors of complement activation (RCA) familySimilarity: Contains 8 Sushi (CCP/SCR) domains |
Function
for CR1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for CR1L:complement component (3b/4b) receptor 1-like (see RCA@)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CR1L (NM_175710) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CR1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CR1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CR1L |
|
Pathways & Interactions
for CR1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CR1L
|
Drugs & Compounds
for CR1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CR1L
Search CenterWatch for drugs/clinical trials and news about CR1L
|
Transcripts
for CR1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CR1L gene: NM_175710.1 Unigene Cluster for CR1L: Complement component (3b/4b) receptor 1-like Hs.655194 [show with all ESTs]Unigene Representative Sequence: NM_1757105 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531844 ENST00000508064(uc001hfz.2 uc001hga.4) ENST00000430248
ENST00000530905 ENST00000294997(uc001hgb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CR1L (NM_175710) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CR1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CR1L |
Additional cDNA sequence: AY114160.1 BC109190.1 BC109191.1 5 DOTS entries: DT.86841396 DT.40202520 DT.86852962 DT.112655 DT.99972271 24/30 AceView cDNA sequences (see all 30): BX094042 AY114160 AI240881 T66824 BU662562 AI735459 T66823 BU662944 BE552138 M11617 T27695 AW609089 BF374618 AW809858 H73873 BF240184 AW293797 R01561 BE842195 R00897 BE842236 BE842203 BF374648 AW387993
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CR1L About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CR1L
|
Expression
for CR1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CR1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACTCCT
About this image
See CR1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CR1L
SOURCE GeneReport for Unigene cluster: Hs.655194
UniProtKB/Swiss-Prot: CR1L_HUMAN, Q2VPA4Tissue specificity: Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears tobe limited to hematopoietic and fetal lymphoid tissue
SABiosciences Custom PCR Arrays for CR1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CR1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CR1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CR1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CR1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CR1L |
Orthologs
for CR1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CR1L gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for CR1L (if available)
TreeFam Gene Tree for CR1L (if available) |
Paralogs
for CR1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CR1L gene
- CSMD12 SEZ6L22 SELP2 C4BPA2 CR22 SELL2 CSMD32 SEZ62
- SELE2 SEZ6L2 CSMD22 CR12 CD552 CD462 SVEP12
6 SIMAP similar genes for CR1L using alignment to 1 protein entry: CR1L_HUMAN:CR1 cd21 CD46 CD55 DAF C4BPB
CR1L for paralogs About GeneDecksing
|
Genomic Variants
for CR1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CR1L (207818458 - 207911761 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 24 variations for CR1L
15/16 CNVs (see all 16): 30452 74882 84832 84833 74883 74884 84834 74885 84829 31683 74886 65764 84831 84837 30453
8 Indels: 84838 84835 74879 71099 84836 74881 74880 84830 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CR1L |
|
Disorders
/ Diseases
for CR1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CR1L for disorders About GeneDecksing
OMIM gene information: 605886
OMIM disorders: --
3  diseases for CR1L: About MalaCardscomplement component receptor 1 abdominal aortic aneurysm aortic aneurysm
Export disorders for CR1L gene to outside databases
|
Publications
for CR1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CR1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with CR1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue. (PubMed id 14687939)1, 2 Logar C.M.... Birmingham D.J. (2004)
- Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. (PubMed id 2295627)1, 3 Hourcade D.... Atkinson J.P. (1990)
- Complement receptor 1 gene variants are associated wi th erythrocyte sedimentation rate. (PubMed id 21700265)1 Kullo I.J....Chute C.G. (2011)
- Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PubMed id 19060910)1 Sabatti C....Peltonen L. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
|
External Searches for CR1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CR1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CR1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CR1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CR1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CR1L gene:
Search GeneIP for patents involving CR1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CR1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CR1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CR1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CR1L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CR1L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CR1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CR1L | | OriGene Custom Protein Services for CR1L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CR1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CR1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CR1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CR1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CR1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CR1L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CR1L |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CR1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CR1L |
|  |  |  | | | | ThermoFisher Antibodies for CR1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CR1L |
|
|
|
|
