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Aliases for CR1L Gene

Aliases for CR1L Gene

  • Complement Component (3b/4b) Receptor 1-Like 2 3
  • Complement C4b-Binding Protein CR-1-Like Protein 4

External Ids for CR1L Gene

Previous GeneCards Identifiers for CR1L Gene

  • GC01P206492
  • GC01P203528
  • GC01P204461
  • GC01P204579
  • GC01P204581
  • GC01P204206
  • GC01P205885
  • GC01P207820
  • GC01P178493
  • GC01P207826

Summaries for CR1L Gene

GeneCards Summary for CR1L Gene

CR1L (Complement Component (3b/4b) Receptor 1-Like) is a Protein Coding gene. An important paralog of this gene is CSMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1L Gene

Genomics for CR1L Gene

Regulatory Elements for CR1L Gene

Genomic Location for CR1L Gene

Start:
207,645,113 bp from pter
End:
207,738,416 bp from pter
Size:
93,304 bases
Orientation:
Plus strand

Genomic View for CR1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR1L Gene

Proteins for CR1L Gene

  • Protein details for CR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPA4-CR1L_HUMAN
    Recommended name:
    Complement component receptor 1-like protein
    Protein Accession:
    Q2VPA4
    Secondary Accessions:
    • Q32MC9
    • Q8NEU7

    Protein attributes for CR1L Gene

    Size:
    569 amino acids
    Molecular mass:
    62714 Da
    Quaternary structure:
    • Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).

    Alternative splice isoforms for CR1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CR1L Gene

Proteomics data for CR1L Gene at MOPED

Post-translational modifications for CR1L Gene

  • Glycosylation at Asn48 and Asn437
  • Modification sites at PhosphoSitePlus

Other Protein References for CR1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CR1L Gene

Domains for CR1L Gene

Gene Families for CR1L Gene

HGNC:

Protein Domains for CR1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VPA4

UniProtKB/Swiss-Prot:

CR1L_HUMAN :
  • Q2VPA4
Domain:
  • Contains 8 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR1L: view

Function for CR1L Gene

Molecular function for CR1L Gene

GENATLAS Biochemistry: complement component (3b/4b) receptor 1-like (see RCA@)

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CR1L Gene

Localization for CR1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR1L Gene

Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CR1L Gene COMPARTMENTS Subcellular localization image for CR1L gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with CR1L: view

Pathways for CR1L Gene

SuperPathways for CR1L Gene

No Data Available

Interacting Proteins for CR1L Gene

Gene Ontology (GO) - Biological Process for CR1L Gene

None

No data available for Pathways by source for CR1L Gene

Transcripts for CR1L Gene

mRNA/cDNA for CR1L Gene

Unigene Clusters for CR1L Gene

Complement component (3b/4b) receptor 1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CR1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CR1L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CR1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -

Relevant External Links for CR1L Gene

GeneLoc Exon Structure for
CR1L
ECgene alternative splicing isoforms for
CR1L

Expression for CR1L Gene

mRNA expression in normal human tissues for CR1L Gene

mRNA differential expression in normal tissues according to GTEx for CR1L Gene

This gene is overexpressed in Whole Blood (22.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CR1L Gene

SOURCE GeneReport for Unigene cluster for CR1L Gene Hs.655194

mRNA Expression by UniProt/SwissProt for CR1L Gene

Q2VPA4-CR1L_HUMAN
Tissue specificity: Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.
genes like me logo Genes that share expressions with CR1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CR1L Gene

Orthologs for CR1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CR1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CR1L 35
  • 94.2 (n)
  • 92.27 (a)
CR1L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cr1l 35
  • 66.37 (n)
  • 54.05 (a)
Cr1l 36
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cr1l 35
  • 58.4 (n)
  • 47 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii sele 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
OneToMany
Species with no ortholog for CR1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CR1L Gene

ENSEMBL:
Gene Tree for CR1L (if available)
TreeFam:
Gene Tree for CR1L (if available)

Paralogs for CR1L Gene

Paralogs for CR1L Gene

Selected SIMAP similar genes for CR1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CR1L: view

Variants for CR1L Gene

Sequence variations from dbSNP and Humsavar for CR1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3085 - 207,683,909(-) TGAGA(C/T)GATGC reference, missense
rs584814 -- 207,677,800(+) GAAAA(C/T)CCCCA intron-variant
rs585637 -- 207,684,422(+) TCTTA(A/G)AATTT intron-variant
rs596615 -- 207,684,589(+) CATTA(C/T)AAAGA intron-variant
rs596966 -- 207,684,611(+) AACAT(A/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CR1L Gene

Variant ID Type Subtype PubMed ID
dgv175e1 CNV Complex 17122850
esv2722106 CNV Deletion 23290073
esv2675458 CNV Deletion 23128226
esv2722117 CNV Deletion 23290073
nsv8735 CNV Gain 18304495
nsv8746 CNV Loss 18304495
esv2676306 CNV Deletion 23128226
esv25546 CNV Loss 19812545
esv27524 CNV Loss 19812545
nsv8757 CNV Gain 18304495

Relevant External Links for CR1L Gene

HapMap Linkage Disequilibrium report
CR1L
Human Gene Mutation Database (HGMD)
CR1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CR1L Gene

Disorders for CR1L Gene

Relevant External Links for CR1L

Genetic Association Database (GAD)
CR1L
genes like me logo Genes that share disorders with CR1L: view

No data available for UniProtKB/Swiss-Prot for CR1L Gene

Publications for CR1L Gene

  1. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. (PMID: 2295627) Hourcade D. … Atkinson J.P. (J. Biol. Chem. 1990) 2 3
  2. A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue. (PMID: 14687939) Logar C.M. … Birmingham D.J. (Mol. Immunol. 2004) 3 4
  3. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C. … Peltonen L. (Nat. Genet. 2009) 3 48
  4. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. (PMID: 21700265) Kullo I.J. … Chute C.G. (Am. J. Hum. Genet. 2011) 3 48
  5. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for CR1L Gene

Sources for CR1L Gene

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