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Aliases for CR1L Gene

Aliases for CR1L Gene

  • Complement Component 3b/4b Receptor 1-Like 2 3
  • Complement Component (3b/4b) Receptor 1-Like 2 5
  • Complement C4b-Binding Protein CR-1-Like Protein 4

External Ids for CR1L Gene

Previous GeneCards Identifiers for CR1L Gene

  • GC01P206492
  • GC01P203528
  • GC01P204461
  • GC01P204579
  • GC01P204581
  • GC01P204206
  • GC01P205885
  • GC01P207820
  • GC01P178493
  • GC01P207826

Summaries for CR1L Gene

GeneCards Summary for CR1L Gene

CR1L (Complement Component 3b/4b Receptor 1-Like) is a Protein Coding gene. Diseases associated with CR1L include Complement Component Receptor 1 and Vascular Hemostatic Disease. An important paralog of this gene is CSMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1L Gene

Genomics for CR1L Gene

Regulatory Elements for CR1L Gene

Enhancers for CR1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CR1L on UCSC Golden Path with GeneCards custom track

Promoters for CR1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CR1L on UCSC Golden Path with GeneCards custom track

Genomic Location for CR1L Gene

207,645,113 bp from pter
207,738,416 bp from pter
93,304 bases
Plus strand

Genomic View for CR1L Gene

Genes around CR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR1L Gene

Proteins for CR1L Gene

  • Protein details for CR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component receptor 1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q32MC9
    • Q8NEU7

    Protein attributes for CR1L Gene

    569 amino acids
    Molecular mass:
    62714 Da
    Quaternary structure:
    • Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).

    Alternative splice isoforms for CR1L Gene


neXtProt entry for CR1L Gene

Proteomics data for CR1L Gene at MOPED

Post-translational modifications for CR1L Gene

  • Glycosylation at Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for CR1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CR1L Gene

Domains & Families for CR1L Gene

Gene Families for CR1L Gene

Protein Domains for CR1L Gene


Suggested Antigen Peptide Sequences for CR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
  • Contains 8 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR1L: view

Function for CR1L Gene

Molecular function for CR1L Gene

GENATLAS Biochemistry:
complement component (3b/4b) receptor 1-like (see RCA@)
genes like me logo Genes that share phenotypes with CR1L: view

Animal Models for CR1L Gene

MGI Knock Outs for CR1L:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CR1L Gene

Localization for CR1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR1L Gene

Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.

Subcellular locations from

Jensen Localization Image for CR1L Gene COMPARTMENTS Subcellular localization image for CR1L gene
Compartment Confidence
extracellular 4
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with CR1L: view

Pathways & Interactions for CR1L Gene

SuperPathways for CR1L Gene

No Data Available

Interacting Proteins for CR1L Gene

Gene Ontology (GO) - Biological Process for CR1L Gene


No data available for Pathways by source and SIGNOR curated interactions for CR1L Gene

Drugs & Compounds for CR1L Gene

No Compound Related Data Available

Transcripts for CR1L Gene

Unigene Clusters for CR1L Gene

Complement component (3b/4b) receptor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CR1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for CR1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CR1L Gene

mRNA expression in normal human tissues for CR1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CR1L Gene

This gene is overexpressed in Whole Blood (x22.6).

Protein differential expression in normal tissues from HIPED for CR1L Gene

This gene is overexpressed in Serum (50.9) and Peripheral blood mononuclear cells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CR1L Gene

SOURCE GeneReport for Unigene cluster for CR1L Gene Hs.655194

mRNA Expression by UniProt/SwissProt for CR1L Gene

Tissue specificity: Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.
genes like me logo Genes that share expression patterns with CR1L: view

Protein tissue co-expression partners for CR1L Gene

- Elite partner

Primer Products

Orthologs for CR1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CR1L Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Cr1l 35
  • 66.37 (n)
  • 54.05 (a)
Cr1l 16
Cr1l 36
  • 40 (a)
(Pan troglodytes)
Mammalia CR1L 35
  • 94.2 (n)
  • 92.27 (a)
CR1L 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Cr1l 35
  • 58.4 (n)
  • 47 (a)
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
(Danio rerio)
Actinopterygii sele 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
Species with no ortholog for CR1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CR1L Gene

Gene Tree for CR1L (if available)
Gene Tree for CR1L (if available)

Paralogs for CR1L Gene

Paralogs for CR1L Gene

(4) SIMAP similar genes for CR1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CR1L: view

Variants for CR1L Gene

Sequence variations from dbSNP and Humsavar for CR1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2296158 - 207,678,266(+) AGTTC(A/G)GATCC reference, missense
rs3085 - 207,683,909(-) TGAGA(C/T)GATGC reference, missense
rs12729569 - 207,699,250(+) TTTGG(A/G)ATAGC reference, missense
rs6683902 - 207,708,212(+) AATGT(A/G)TCCTC reference, missense
rs2796257 - 207,717,521(+) TCCCC(C/T)TGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CR1L Gene

Variant ID Type Subtype PubMed ID
dgv175e1 CNV Complex 17122850
esv2722106 CNV Deletion 23290073
esv2675458 CNV Deletion 23128226
esv2722117 CNV Deletion 23290073
nsv8735 CNV Gain 18304495
nsv8746 CNV Loss 18304495
esv2676306 CNV Deletion 23128226
esv25546 CNV Loss 19812545
esv27524 CNV Loss 19812545
nsv8757 CNV Gain 18304495

Variation tolerance for CR1L Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CR1L Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CR1L Gene

Disorders for CR1L Gene

MalaCards: The human disease database

(3) MalaCards diseases for CR1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
complement component receptor 1
vascular hemostatic disease
  • hemostatic disorders
cavernous hemangioma
  • cavernoma
- elite association - COSMIC cancer census association via MalaCards
Search CR1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CR1L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CR1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CR1L Gene

Publications for CR1L Gene

  1. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. (PMID: 21700265) Kullo I.J. … Chute C.G. (Am. J. Hum. Genet. 2011) 3 48 67
  2. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. (PMID: 2295627) Hourcade D. … Atkinson J.P. (J. Biol. Chem. 1990) 2 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C. … Peltonen L. (Nat. Genet. 2009) 3

Products for CR1L Gene

Sources for CR1L Gene