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Aliases for CR1L Gene

Aliases for CR1L Gene

  • Complement C3b/C4b Receptor 1 Like 2 3 5
  • Complement C4b-Binding Protein CR-1-Like Protein 4
  • Complement Component (3b/4b) Receptor 1-Like 2

External Ids for CR1L Gene

Previous GeneCards Identifiers for CR1L Gene

  • GC01P206492
  • GC01P203528
  • GC01P204461
  • GC01P204579
  • GC01P204581
  • GC01P204206
  • GC01P205885
  • GC01P207820
  • GC01P178493
  • GC01P207826

Summaries for CR1L Gene

GeneCards Summary for CR1L Gene

CR1L (Complement C3b/C4b Receptor 1 Like) is a Protein Coding gene. Diseases associated with CR1L include Complement Component Receptor 1 and Vascular Hemostatic Disease. An important paralog of this gene is CR1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1L Gene

Genomics for CR1L Gene

Regulatory Elements for CR1L Gene

Enhancers for CR1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F207649 1.4 FANTOM5 ENCODE 23.1 +4.8 4836 1.8 HDGF PKNOX1 ARNT SIN3A DMAP1 FEZF1 YY1 ZNF302 ZNF143 ZNF207 CR1L CDCA4P4 C4BPA MIR29B2 MIR29C C1orf132 CR2 CDCA4P3
GH01F207816 1.8 FANTOM5 Ensembl ENCODE 5.1 +177.8 177761 12.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF302 CD46 C1orf132 MIR29B2 MIR29C CD34 CR1 PLXNA2 CR1L PIR33548 GC01P207829
GH01F207747 1.7 FANTOM5 Ensembl ENCODE 5.3 +106.0 106023 6.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 CD46 MIR29C MIR29B2 C1orf132 CR1L GC01P207741
GH01F207846 1.6 FANTOM5 Ensembl ENCODE 5.1 +205.5 205483 7.6 PKNOX1 ARNT CREB3L1 SIN3A ZNF2 ZNF302 FOS DEK ZNF263 MCM3 CD46 LINC01717 C1orf132 MIR29C MIR29B2 CD34 CR1L PLXNA2 CR1 GC01P207829
GH01F207648 0.6 FANTOM5 13.2 +3.4 3419 0.2 TAL1 IKZF1 PRDM10 MLLT1 CR1L C4BPA C1orf132 MIR29B2 MIR29C CDCA4P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CR1L on UCSC Golden Path with GeneCards custom track

Promoters for CR1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CR1L Gene

207,645,113 bp from pter
207,738,416 bp from pter
93,304 bases
Plus strand

Genomic View for CR1L Gene

Genes around CR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR1L Gene

Proteins for CR1L Gene

  • Protein details for CR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component receptor 1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q32MC9
    • Q8NEU7

    Protein attributes for CR1L Gene

    569 amino acids
    Molecular mass:
    62714 Da
    Quaternary structure:
    • Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).

    Alternative splice isoforms for CR1L Gene


neXtProt entry for CR1L Gene

Post-translational modifications for CR1L Gene

  • Glycosylation at Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for CR1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CR1L Gene

Domains & Families for CR1L Gene

Gene Families for CR1L Gene

Protein Domains for CR1L Gene


Suggested Antigen Peptide Sequences for CR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
  • Contains 8 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR1L: view

Function for CR1L Gene

Molecular function for CR1L Gene

GENATLAS Biochemistry:
complement component (3b/4b) receptor 1-like (see RCA@)
genes like me logo Genes that share phenotypes with CR1L: view

Animal Models for CR1L Gene

MGI Knock Outs for CR1L:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CR1L Gene

Localization for CR1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR1L Gene

Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CR1L gene
Compartment Confidence
extracellular 4
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with CR1L: view

Pathways & Interactions for CR1L Gene

No Data Available

Interacting Proteins for CR1L Gene

Selected Interacting proteins: Q2VPA4-CR1L_HUMAN for CR1L Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CR1L Gene


No data available for Pathways by source and SIGNOR curated interactions for CR1L Gene

Transcripts for CR1L Gene

Unigene Clusters for CR1L Gene

Complement component (3b/4b) receptor 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CR1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for CR1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CR1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CR1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CR1L Gene

This gene is overexpressed in Whole Blood (x22.6).

Protein differential expression in normal tissues from HIPED for CR1L Gene

This gene is overexpressed in Serum (50.9) and Peripheral blood mononuclear cells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CR1L Gene

Protein tissue co-expression partners for CR1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CR1L Gene:


SOURCE GeneReport for Unigene cluster for CR1L Gene:


mRNA Expression by UniProt/SwissProt for CR1L Gene:

Tissue specificity: Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.
genes like me logo Genes that share expression patterns with CR1L: view

Primer Products

Orthologs for CR1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CR1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CR1L 34 35
  • 94.2 (n)
(Mus musculus)
Mammalia Cr1l 34 16 35
  • 66.37 (n)
(Rattus norvegicus)
Mammalia Cr1l 34
  • 58.4 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
(Canis familiaris)
Mammalia -- 35
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
(Danio rerio)
Actinopterygii sele 35
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 4 (a)
Species where no ortholog for CR1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CR1L Gene

Gene Tree for CR1L (if available)
Gene Tree for CR1L (if available)

Paralogs for CR1L Gene

Paralogs for CR1L Gene

(4) SIMAP similar genes for CR1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CR1L: view

Variants for CR1L Gene

Sequence variations from dbSNP and Humsavar for CR1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10081975 -- 207,654,592(+) CTATA(C/T)TCAAT intron-variant
rs10082154 -- 207,657,038(+) CTATA(C/T)TGACA intron-variant
rs10494884 -- 207,674,531(-) TTTGC(A/G)TAGTA intron-variant
rs10523807 -- 207,707,785(+) GTATT(-/AC/ACAC/ACACACACACACACACACAC)ACACA intron-variant
rs10573245 -- 207,648,588(+) GAAAC(-/AT)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CR1L Gene

Variant ID Type Subtype PubMed ID
nsv945269 CNV duplication 23825009
nsv8757 CNV gain 18304495
nsv8746 CNV loss 18304495
nsv8735 CNV gain 18304495
esv3891082 CNV loss 25118596
esv3588675 CNV loss 21293372
esv3588674 CNV gain 21293372
esv3578397 CNV loss 25503493
esv3545666 CNV deletion 23714750
esv2758993 CNV gain+loss 17122850
esv27524 CNV loss 19812545
esv2722117 CNV deletion 23290073
esv2722106 CNV deletion 23290073
esv2676306 CNV deletion 23128226
esv2675458 CNV deletion 23128226
esv25546 CNV loss 19812545

Variation tolerance for CR1L Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CR1L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CR1L Gene

Disorders for CR1L Gene

MalaCards: The human disease database

(2) MalaCards diseases for CR1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
complement component receptor 1
  • complement component receptor-1
vascular hemostatic disease
  • hemostatic disorders
- elite association - COSMIC cancer census association via MalaCards
Search CR1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CR1L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CR1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CR1L Gene

Publications for CR1L Gene

  1. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. (PMID: 21700265) Kullo I.J. … Chute C.G. (Am. J. Hum. Genet. 2011) 3 46 64
  2. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C. … Peltonen L. (Nat. Genet. 2009) 3 46 64
  3. A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue. (PMID: 14687939) Logar C.M. … Birmingham D.J. (Mol. Immunol. 2004) 3 4 64
  4. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. (PMID: 2295627) Hourcade D. … Atkinson J.P. (J. Biol. Chem. 1990) 2 3 64
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64

Products for CR1L Gene

Sources for CR1L Gene

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