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Aliases for CR1 Gene

Aliases for CR1 Gene

  • Complement Component 3b/4b Receptor 1 (Knops Blood Group) 2 3
  • Complement Component (3b/4b) Receptor 1 (Knops Blood Group) 2 3 5
  • C3b/C4b Receptor 3 4
  • CD35 Antigen 3 4
  • C3BR 3 4
  • Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System 2
  • Knops Blood Group Antigen 3
  • C3-Binding Protein 3
  • C4BR 3
  • CD35 3
  • KN 3

External Ids for CR1 Gene

Previous GeneCards Identifiers for CR1 Gene

  • GC01P206329
  • GC01P203379
  • GC01P204312
  • GC01P204753
  • GC01P204057
  • GC01P205736
  • GC01P207669
  • GC01P178362

Summaries for CR1 Gene

Entrez Gene Summary for CR1 Gene

  • This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CR1 Gene

CR1 (Complement Component 3b/4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Plasmodium Falciparum Malaria. Among its related pathways are Immune response Lectin induced complement pathway and Toxoplasmosis. GO annotations related to this gene include complement component C3b binding and complement component C4b receptor activity. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for CR1 Gene

  • Mediates cellular binding of particles and immune complexes that have activated complement.

  • (Microbial infection) Acts as a receptor for Epstein-Barr virus.

Gene Wiki entry for CR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1 Gene

Genomics for CR1 Gene

Regulatory Elements for CR1 Gene

Enhancers for CR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CR1 on UCSC Golden Path with GeneCards custom track

Promoters for CR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CR1 Gene

207,496,128 bp from pter
207,641,765 bp from pter
145,638 bases
Plus strand

Genomic View for CR1 Gene

Genes around CR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR1 Gene

Proteins for CR1 Gene

  • Protein details for CR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement receptor type 1
    Protein Accession:
    Secondary Accessions:
    • Q16744
    • Q16745
    • Q5SR43
    • Q5SR45
    • Q9UQV2

    Protein attributes for CR1 Gene

    2039 amino acids
    Molecular mass:
    223663 Da
    Quaternary structure:
    • Monomer.
    • (Microbial infection) Interacts with Epstein-Barr virus gp350.

    Three dimensional structures from OCA and Proteopedia for CR1 Gene

neXtProt entry for CR1 Gene

Proteomics data for CR1 Gene at MOPED

Post-translational modifications for CR1 Gene

  • Glycosylation at Asn 56, Asn 156, Asn 252, Asn 410, Asn 447, Asn 509, Asn 578, Asn 702, Asn 860, Asn 897, Asn 959, Asn 1028, Asn 1152, Asn 1310, Asn 1481, Asn 1504, Asn 1534, Asn 1540, Asn 1605, Asn 1763, and Asn 1908
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CR1 Gene

Domains & Families for CR1 Gene

Protein Domains for CR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 30 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
  • Contains 30 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR1: view

Function for CR1 Gene

Molecular function for CR1 Gene

GENATLAS Biochemistry:
complement component (3b/4b) receptor 1 (see RCA@)
UniProtKB/Swiss-Prot Function:
Mediates cellular binding of particles and immune complexes that have activated complement.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Epstein-Barr virus.
genes like me logo Genes that share phenotypes with CR1: view

Animal Model Products

miRNA for CR1 Gene

miRTarBase miRNAs that target CR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CR1 Gene

Localization for CR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CR1 Gene COMPARTMENTS Subcellular localization image for CR1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CR1 Gene

Pathways & Interactions for CR1 Gene

genes like me logo Genes that share pathways with CR1: view

Gene Ontology (GO) - Biological Process for CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0045957 negative regulation of complement activation, alternative pathway IDA 10531307
GO:0046718 viral entry into host cell IEA --
GO:1900005 positive regulation of serine-type endopeptidase activity IDA 2972794
genes like me logo Genes that share ontologies with CR1: view

No data available for SIGNOR curated interactions for CR1 Gene

Drugs & Compounds for CR1 Gene

(19) Drugs for CR1 Gene - From: PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Eculizumab Approved, Investigational Pharma 0
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 45
4'-N-benzoylstaurosporine Pharma 23
Protein Kinase Inhibitors Pharma 3500

(26) Additional Compounds for CR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CR1: view

Transcripts for CR1 Gene

Unigene Clusters for CR1 Gene

Complement component (3b/4b) receptor 1 (Knops blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CR1 Gene

No ASD Table

Relevant External Links for CR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CR1 Gene

mRNA expression in normal human tissues for CR1 Gene

mRNA differential expression in normal tissues according to GTEx for CR1 Gene

This gene is overexpressed in Whole Blood (x31.7) and Spleen (x7.4).

Protein differential expression in normal tissues from HIPED for CR1 Gene

This gene is overexpressed in Urine (50.9) and Neutrophil (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CR1 Gene

SOURCE GeneReport for Unigene cluster for CR1 Gene Hs.334019

mRNA Expression by UniProt/SwissProt for CR1 Gene

Tissue specificity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
genes like me logo Genes that share expression patterns with CR1: view

Protein tissue co-expression partners for CR1 Gene

- Elite partner

Primer Products

Orthologs for CR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC102157092 35
  • 69.17 (n)
  • 57.18 (a)
-- 36
  • 52 (a)
(Pan troglodytes)
Mammalia CR1 35
  • 97.13 (n)
  • 96.25 (a)
CR1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
(Mus musculus)
Mammalia Cr1l 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
(Danio rerio)
Actinopterygii ntd5 36
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10186 37
  • 26 (a)
fw 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea T07H6.5 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
Species with no ortholog for CR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CR1 Gene

Gene Tree for CR1 (if available)
Gene Tree for CR1 (if available)

Paralogs for CR1 Gene

Paralogs for CR1 Gene Pseudogenes for CR1 Gene

genes like me logo Genes that share paralogs with CR1: view

Variants for CR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CR1 Gene

CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.
Genetic variations in CR1 resulting in CR1 deficiency are involved in protection against severe malaria [MIM:611162]. Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as rosettes. CR1-deficient red blood cells show greatly reduced rosetting and CR1 deficiency occurs in healthy individuals from malaria-endemic regions.
Other polymorphic forms of CR1 contain 23, 37 or 44 Sushi (CCP/SCR) domains instead of the 30 Sushi (CCP/SCR) domains. The most frequent alleles are the F allotype (shown here) and the S allotype (37 repeat Sushi domains). The gene frequencies of the F allotype and S allotype are 0.87 and 0.11 in Caucasians, 0.82 and 0.11 in African Americans, 0.89 and 0.11 in Mexicans.

Sequence variations from dbSNP and Humsavar for CR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2274567 - 207,580,276(+) TGAGC(A/G)TACCC reference, missense
VAR_013820 -
rs17047660 - 207,609,511(+) CTAAT(A/G)AATGC reference, missense
rs17047661 - 207,609,544(+) CAATT(A/G)GAGTA reference, missense
rs4844609 - 207,609,571(+) TCTTT(A/T)CCCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CR1 Gene

Variant ID Type Subtype PubMed ID
dgv174e1 CNV Complex 17122850
dgv175e1 CNV Complex 17122850
esv2722106 CNV Deletion 23290073
nsv508690 CNV Loss 20534489
nsv4232 CNV Loss 18451855
nsv821188 CNV Deletion 20802225
nsv826476 CNV Loss 20364138
esv26263 CNV Gain+Loss 19812545
nsv124 CNV Loss 15895083
nsv8724 CNV Gain+Loss 18304495
nsv471426 CNV Duplication 19718026
nsv514918 CNV Complex 21397061
dgv94e199 CNV Deletion 23128226
dgv5n47 CNV Loss 21111241
esv2675458 CNV Deletion 23128226
dgv6n47 CNV Loss 21111241
nsv436034 CNV Insertion 17901297
esv33009 CNV Gain+Loss 17666407
nsv514919 CNV Complex 21397061
esv2722117 CNV Deletion 23290073
nsv826487 CNV Gain 20364138

Variation tolerance for CR1 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.67; 93.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CR1 Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for CR1 Gene

MalaCards: The human disease database

(25) MalaCards diseases for CR1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malaria, severe
plasmodium falciparum malaria
  • falciparum malaria
viral pneumonia
  • pneumonia, viral
alzheimer disease risk factor
- elite association - COSMIC cancer census association via MalaCards
Search CR1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for CR1 Gene

lupus systemic syndrome

Relevant External Links for CR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CR1: view

No data available for UniProtKB/Swiss-Prot for CR1 Gene

Publications for CR1 Gene

  1. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. (PMID: 14694201) Cockburn I.A. … Rowe J.A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 48 67
  2. The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera. (PMID: 1708809) Moulds J.M. … Atkinson J.P. (J. Exp. Med. 1991) 2 3 23
  3. CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity. (PMID: 19480840) Sinha S. … Habib S. (Hum. Immunol. 2009) 3 23
  4. Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1. (PMID: 18684861) Ghiran I. … Nicholson-Weller A. (Blood 2008) 3 23
  5. Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene. (PMID: 16426237) Cockburn I.A. … Rowe J.A. (Int. J. Immunogenet. 2006) 3 23

Products for CR1 Gene

Sources for CR1 Gene