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Aliases for CPZ Gene

Aliases for CPZ Gene

  • Carboxypeptidase Z 2 3 5
  • Metallocarboxypeptidase Z 2
  • EC 63
  • EC 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPZ Gene

Previous GeneCards Identifiers for CPZ Gene

  • GC04P008774
  • GC04P008786
  • GC04P008712

Summaries for CPZ Gene

Entrez Gene Summary for CPZ Gene

  • This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPZ Gene

CPZ (Carboxypeptidase Z) is a Protein Coding gene. Diseases associated with CPZ include Yaws. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot for CPZ Gene

  • Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

Gene Wiki entry for CPZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPZ Gene

Genomics for CPZ Gene

Regulatory Elements for CPZ Gene

Enhancers for CPZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPZ on UCSC Golden Path with GeneCards custom track

Promoters for CPZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPZ on UCSC Golden Path with GeneCards custom track

Genomic Location for CPZ Gene

8,592,660 bp from pter
8,619,761 bp from pter
27,102 bases
Plus strand

Genomic View for CPZ Gene

Genes around CPZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPZ Gene

Proteins for CPZ Gene

  • Protein details for CPZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase Z
    Protein Accession:
    Secondary Accessions:
    • O00520
    • Q96MX2

    Protein attributes for CPZ Gene

    652 amino acids
    Molecular mass:
    73655 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • Sequence=BAB71147.1; Type=Frameshift; Positions=358; Evidence={ECO:0000305};

    Alternative splice isoforms for CPZ Gene


neXtProt entry for CPZ Gene

Proteomics data for CPZ Gene at MOPED

Post-translational modifications for CPZ Gene

Other Protein References for CPZ Gene

Antibody Products

Domains & Families for CPZ Gene

Gene Families for CPZ Gene

Suggested Antigen Peptide Sequences for CPZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FZ (frizzled) domain.
  • Belongs to the peptidase M14 family.
  • Contains 1 FZ (frizzled) domain.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPZ: view

Function for CPZ Gene

Molecular function for CPZ Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2 mM for dansyl-Phe-Ala-Arg {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699}; KM=2 mM for dansyl-Pro-Ala-Arg {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699}; pH dependence: Optimum pH is 7.8. {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA.
UniProtKB/Swiss-Prot Function:
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

Enzyme Numbers (IUBMB) for CPZ Gene

genes like me logo Genes that share phenotypes with CPZ: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPZ

miRNA for CPZ Gene

miRTarBase miRNAs that target CPZ

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPZ Gene

Localization for CPZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPZ Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for CPZ Gene COMPARTMENTS Subcellular localization image for CPZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CPZ Gene

Pathways & Interactions for CPZ Gene

SuperPathways for CPZ Gene

No Data Available

Interacting Proteins for CPZ Gene

Gene Ontology (GO) - Biological Process for CPZ Gene


No data available for Pathways by source and SIGNOR curated interactions for CPZ Gene

Drugs & Compounds for CPZ Gene

No Compound Related Data Available

Transcripts for CPZ Gene

Unigene Clusters for CPZ Gene

Carboxypeptidase Z:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPZ Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: -
SP6: -
SP7: - -
SP8: - - -
SP10: -

Relevant External Links for CPZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPZ Gene

mRNA expression in normal human tissues for CPZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPZ Gene

This gene is overexpressed in Ovary (x21.9).

Protein differential expression in normal tissues from HIPED for CPZ Gene

This gene is overexpressed in Plasma (48.1) and Urine (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPZ Gene

SOURCE GeneReport for Unigene cluster for CPZ Gene Hs.61995

mRNA Expression by UniProt/SwissProt for CPZ Gene

Tissue specificity: In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with CPZ: view

No data available for Protein tissue co-expression partners for CPZ Gene

Orthologs for CPZ Gene

This gene was present in the common ancestor of animals.

Orthologs for CPZ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPZ 35
  • 86.62 (n)
  • 87.36 (a)
CPZ 36
  • 86 (a)
(Canis familiaris)
Mammalia CPZ 35
  • 84.1 (n)
  • 84.79 (a)
CPZ 36
  • 84 (a)
(Mus musculus)
Mammalia Cpz 35
  • 82.27 (n)
  • 83.12 (a)
Cpz 16
Cpz 36
  • 81 (a)
(Pan troglodytes)
Mammalia CPZ 35
  • 97.71 (n)
  • 97.85 (a)
CPZ 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Cpz 35
  • 81.9 (n)
  • 84.71 (a)
(Monodelphis domestica)
Mammalia CPZ 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia CPZ 36
  • 70 (a)
(Gallus gallus)
Aves CPZ 35
  • 65.28 (n)
  • 66.35 (a)
CPZ 36
  • 66 (a)
(Anolis carolinensis)
Reptilia CPZ 36
  • 11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpz 35
  • 65.95 (n)
  • 64.12 (a)
Str.12000 35
(Danio rerio)
Actinopterygii cpz 35
  • 61.57 (n)
  • 58.62 (a)
cpz 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea F01D4.4 37
  • 40 (a)
F59A3.1 37
  • 41 (a)
egl-21 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for CPZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPZ Gene

Gene Tree for CPZ (if available)
Gene Tree for CPZ (if available)

Paralogs for CPZ Gene

Paralogs for CPZ Gene

(6) SIMAP similar genes for CPZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CPZ: view

Variants for CPZ Gene

Sequence variations from dbSNP and Humsavar for CPZ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2302583 - 8,592,847(-) GCGGC(A/G/T)GCGGG reference, missense, utr-variant-5-prime
rs9991535 - 8,614,497(+) GGAGA(C/T)GGTGA reference, missense
rs34964084 - 8,592,850(+) GCTGC(C/T)GCTGC reference, missense, utr-variant-5-prime
rs35993494 - 8,601,390(+) CTGCC(A/T)GCCCG reference, missense, utr-variant-5-prime
rs7378066 - 8,614,452(+) GTACA(C/T)ACTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CPZ Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv878604 CNV Gain 21882294
dgv1569e1 CNV Complex 17122850
nsv428437 CNV Gain 18775914
dgv1570e1 CNV Complex 17122850
nsv878612 CNV Gain 21882294
dgv5460n71 CNV Loss 21882294
dgv5461n71 CNV Loss 21882294
nsv878618 CNV Loss 21882294
nsv470015 CNV Loss 18288195
nsv4225 CNV Insertion 18451855
esv33219 CNV Gain 17666407
nsv829855 CNV Gain+Loss 17160897
nsv521867 CNV Loss 19592680
nsv518282 CNV Loss 19592680
nsv4226 CNV Loss 18451855
nsv10442 CNV Gain 18304495

Variation tolerance for CPZ Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPZ Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPZ Gene

Disorders for CPZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPZ Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • bouba
- elite association - COSMIC cancer census association via MalaCards
Search CPZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPZ Gene

Publications for CPZ Gene

  1. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. (PMID: 9099699) Song L. … Fricker L.D. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. (PMID: 12417617) Fan X. … Johnson M.D. (J. Histochem. Cytochem. 2002) 3 23
  3. Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding. (PMID: 11766880) Reznik S.E. … Fricker L.D. (Cell. Mol. Life Sci. 2001) 3 23
  4. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. (PMID: 10671522) Novikova E.G. … Fricker L.D. (J. Biol. Chem. 2000) 3 23
  5. Purification and characterization of human metallocarboxypeptidase Z. (PMID: 10080937) Novikova E.G. … Fricker L.D. (Biochem. Biophys. Res. Commun. 1999) 3 23

Products for CPZ Gene

Sources for CPZ Gene