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Aliases for CPZ Gene

Aliases for CPZ Gene

  • Carboxypeptidase Z 2 3 5
  • Metallocarboxypeptidase Z 2
  • EC 3.4.17.10 61
  • EC 3.4.17.3 61
  • EC 3.4.17.- 4
  • EC 3.4.17 61

External Ids for CPZ Gene

Previous GeneCards Identifiers for CPZ Gene

  • GC04P008774
  • GC04P008786
  • GC04P008712

Summaries for CPZ Gene

Entrez Gene Summary for CPZ Gene

  • This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPZ Gene

CPZ (Carboxypeptidase Z) is a Protein Coding gene. Diseases associated with CPZ include Yaws and Retinitis Pigmentosa 3. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot for CPZ Gene

  • Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

Gene Wiki entry for CPZ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPZ Gene

Genomics for CPZ Gene

Regulatory Elements for CPZ Gene

Enhancers for CPZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G008514 1.1 Ensembl ENCODE dbSUPER 6.9 -76.3 -76326 3.6 MAFG JUND ZNF316 SMARCA4 POLR2A NFE2 FOS EMSY TRMT44 ENSG00000205959 ENSG00000251186 GPR78 CPZ GC04M008538
GH04G008340 1.1 Ensembl ENCODE dbSUPER 6 -250.3 -250324 4.2 SOX5 CTCF PKNOX1 NFIA RAD21 NR2F2 GATA3 PBX2 NR2C2 ENSG00000251615 CPZ ENSG00000205959 LINC02517
GH04G008591 1.5 Ensembl ENCODE dbSUPER 0.7 +0.7 671 3.3 ATF1 PKNOX1 ARNT FEZF1 GLIS2 ZNF263 MIER2 REST SMARCA4 RCOR2 CPZ GC04P008645
GH04G008589 0.8 ENCODE dbSUPER 0.7 -2.8 -2752 0.2 SCRT1 SCRT2 KLF17 ZIC2 CPZ GPR78
GH04G008592 0.7 dbSUPER 0.7 -2.0 -2031 0.6 HDAC1 KLF1 PHF8 NRF1 ZNF398 ZIC2 OSR2 TFDP1 ZFHX2 KDM5B CPZ GPR78
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPZ on UCSC Golden Path with GeneCards custom track

Genomic Location for CPZ Gene

Chromosome:
4
Start:
8,592,660 bp from pter
End:
8,619,761 bp from pter
Size:
27,102 bases
Orientation:
Plus strand

Genomic View for CPZ Gene

Genes around CPZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPZ Gene

Proteins for CPZ Gene

  • Protein details for CPZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K79-CBPZ_HUMAN
    Recommended name:
    Carboxypeptidase Z
    Protein Accession:
    Q66K79
    Secondary Accessions:
    • O00520
    • Q96MX2

    Protein attributes for CPZ Gene

    Size:
    652 amino acids
    Molecular mass:
    73655 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71147.1; Type=Frameshift; Positions=358; Evidence={ECO:0000305};

    Alternative splice isoforms for CPZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPZ Gene

Selected DME Specific Peptides for CPZ Gene

Q66K79:
  • GDYWRLL
  • EGAGYNGW
  • YWWGKVAPETKA
  • YLLGNPRIQ
  • IPFVLSA
  • FSPTPDEKMFK
  • AFDAIDMAWPYFLDC
  • YLHTNCFE
  • PSMNPDGYE
  • DLNRNFPD
  • TYSIGRSF
  • WYSFTGGM

Post-translational modifications for CPZ Gene

  • Glycosylation at isoforms=2, 3281
  • Modification sites at PhosphoSitePlus

Other Protein References for CPZ Gene

Domains & Families for CPZ Gene

Gene Families for CPZ Gene

Suggested Antigen Peptide Sequences for CPZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q66K79

UniProtKB/Swiss-Prot:

CBPZ_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPZ: view

Function for CPZ Gene

Molecular function for CPZ Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2 mM for dansyl-Phe-Ala-Arg {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699}; KM=2 mM for dansyl-Pro-Ala-Arg {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699}; pH dependence: Optimum pH is 7.8. {ECO:0000269 PubMed:10080937, ECO:0000269 PubMed:9099699};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA.
UniProtKB/Swiss-Prot Function:
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

Enzyme Numbers (IUBMB) for CPZ Gene

Gene Ontology (GO) - Molecular Function for CPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity TAS,IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPZ: view
genes like me logo Genes that share phenotypes with CPZ: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPZ

CRISPR Products

miRNA for CPZ Gene

miRTarBase miRNAs that target CPZ

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CPZ
  • Applied Biological Materials Clones for CPZ

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPZ Gene

Localization for CPZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPZ Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CPZ: view

Pathways & Interactions for CPZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 9099699
GO:0006518 peptide metabolic process IBA --
GO:0016055 Wnt signaling pathway IEA --
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CPZ: view

No data available for Pathways by source and SIGNOR curated interactions for CPZ Gene

Drugs & Compounds for CPZ Gene

No Compound Related Data Available

Transcripts for CPZ Gene

Unigene Clusters for CPZ Gene

Carboxypeptidase Z:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CPZ
  • Applied Biological Materials Clones for CPZ

Alternative Splicing Database (ASD) splice patterns (SP) for CPZ Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: -
SP5:
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for CPZ Gene

GeneLoc Exon Structure for
CPZ
ECgene alternative splicing isoforms for
CPZ

Expression for CPZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPZ Gene

This gene is overexpressed in Ovary (x21.9).

Protein differential expression in normal tissues from HIPED for CPZ Gene

This gene is overexpressed in Plasma (48.1) and Urine (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPZ Gene



NURSA nuclear receptor signaling pathways regulating expression of CPZ Gene:

CPZ

SOURCE GeneReport for Unigene cluster for CPZ Gene:

Hs.61995

mRNA Expression by UniProt/SwissProt for CPZ Gene:

Q66K79-CBPZ_HUMAN
Tissue specificity: In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for CPZ Gene

  • Muscle(4)
genes like me logo Genes that share expression patterns with CPZ: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPZ Gene

Orthologs for CPZ Gene

This gene was present in the common ancestor of animals.

Orthologs for CPZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPZ 34 35
  • 97.71 (n)
cow
(Bos Taurus)
Mammalia CPZ 34 35
  • 86.62 (n)
dog
(Canis familiaris)
Mammalia CPZ 34 35
  • 84.1 (n)
mouse
(Mus musculus)
Mammalia Cpz 34 16 35
  • 82.27 (n)
rat
(Rattus norvegicus)
Mammalia Cpz 34
  • 81.9 (n)
oppossum
(Monodelphis domestica)
Mammalia CPZ 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPZ 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPZ 34 35
  • 65.28 (n)
lizard
(Anolis carolinensis)
Reptilia CPZ 35
  • 11 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpz 34
  • 65.95 (n)
Str.12000 34
zebrafish
(Danio rerio)
Actinopterygii cpz 34 35
  • 61.57 (n)
worm
(Caenorhabditis elegans)
Secernentea F59A3.1 36
  • 41 (a)
F01D4.4 36
  • 40 (a)
egl-21 35
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for CPZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPZ Gene

ENSEMBL:
Gene Tree for CPZ (if available)
TreeFam:
Gene Tree for CPZ (if available)

Paralogs for CPZ Gene

Paralogs for CPZ Gene

(6) SIMAP similar genes for CPZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CPZ: view

Variants for CPZ Gene

Sequence variations from dbSNP and Humsavar for CPZ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000018340 -- 8,611,087(+) GCTCA(C/T)TCACT intron-variant
rs1000081859 -- 8,617,085(+) TGGGC(C/G)TGAGC intron-variant
rs1000095056 -- 8,618,129(+) TGGCA(A/G)GAAAG intron-variant
rs1000197796 -- 8,616,438(+) CCTGG(C/G)AGAGC intron-variant
rs1000208259 -- 8,593,553(+) TCCTG(G/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPZ Gene

Variant ID Type Subtype PubMed ID
esv2759222 CNV gain+loss 17122850
esv33219 CNV gain 17666407
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1014219 CNV gain 25217958
nsv10442 CNV gain 18304495
nsv1128032 CNV deletion 24896259
nsv4225 CNV insertion 18451855
nsv4226 CNV deletion 18451855
nsv428437 CNV gain 18775914
nsv470015 CNV loss 18288195
nsv518282 CNV loss 19592680
nsv521867 CNV loss 19592680
nsv829855 CNV gain+loss 17160897
nsv949785 CNV deletion 24416366
nsv949786 CNV duplication 24416366

Variation tolerance for CPZ Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPZ Gene

Human Gene Mutation Database (HGMD)
CPZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPZ Gene

Disorders for CPZ Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
yaws
  • bouba
retinitis pigmentosa 3
  • rp3
- elite association - COSMIC cancer census association via MalaCards
Search CPZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPZ

Genetic Association Database (GAD)
CPZ
Human Genome Epidemiology (HuGE) Navigator
CPZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPZ
genes like me logo Genes that share disorders with CPZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPZ Gene

Publications for CPZ Gene

  1. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. (PMID: 9099699) Song L. … Fricker L.D. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. (PMID: 12417617) Fan X. … Johnson M.D. (J. Histochem. Cytochem. 2002) 3 4 22 64
  3. Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding. (PMID: 11766880) Reznik S.E. … Fricker L.D. (Cell. Mol. Life Sci. 2001) 3 4 22 64
  4. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. (PMID: 10671522) Novikova E.G. … Fricker L.D. (J. Biol. Chem. 2000) 3 4 22 64
  5. Purification and characterization of human metallocarboxypeptidase Z. (PMID: 10080937) Novikova E.G. … Fricker L.D. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64

Products for CPZ Gene

  • Addgene plasmids for CPZ

Sources for CPZ Gene

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