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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPZ Gene

protein-coding   GIFtS: 53
GCID: GC04P008583

carboxypeptidase Z
 Explore 5 diseases affiliated with
CPZ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPZ    

Aliases
for CPZ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase Z1 2
Metallocarboxypeptidase Z2
EC 3.4.17.-3
EC 3.4.178
EC 3.4.17.108
EC 3.4.17.38

External Ids:    HGNC: 23331   Entrez Gene: 85322   Ensembl: ENSG000001096257   OMIM: 6031055   UniProtKB: Q66K793   

Export aliases for CPZ gene to outside databases

Previous GC identifers: GC04P008774 GC04P008786 GC04P008712


Summaries
for CPZ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPZ:
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity
towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active
site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by
cleaving some undefined protein. May play a role in cleavage during prohormone processing

Gene Wiki entry for CPZ


Genomic Views
for CPZ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPZ gene promoter:
         AREB6   NRSF form 1   MyoD   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPZ promoter sequence
   Search SABiosciences Chromatin IP Primers for CPZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

CPZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPZ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P008583:  view genomic region     (about GC identifiers)

Start:
 8,594,387 bp from pter      End:
 8,621,488 bp from pter
Size:
 27,102 bases      Orientation:
 plus strand

Proteins
for CPZ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79 (See protein sequence)
Recommended Name: Carboxypeptidase Z precursor  
Size: 652 amino acids; 73655 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=BAB71147.1; Type=Frameshift; Positions=358;
Secondary accessions: O00520 Q96MX2
Alternative splicing: 3 isoforms:  Q66K79-1   Q66K79-2   Q66K79-3   

Explore the universe of human proteins at neXtProt for CPZ: NX_Q66K79

4/12 DME Specific Peptides for CPZ (Q66K79) (see all 12)
 GDYWRLL  IPFVLSA  EGAGYNGW  WYSFTGGM 

CPZ Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins (3 alternative transcripts): 
NP_001014447.1  NP_001014448.1  NP_003643.2  

ENSEMBL proteins: 
 ENSP00000354255   ENSP00000422693   ENSP00000315074   ENSP00000371920   ENSP00000403981  

Human Recombinant Protein Products: 
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OriGene Protein Over-expression Lysate (see all 2): CPZ
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Browse ProSpec Recombinant Proteins
Uscn Proteins for CPZ

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IEA--


CPZ for ontologies           About GeneDecksing



CPZ Antibody Products: 
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Uscn ELISAs and CLIAs for CPZ

Protein Domains /
Families
for CPZ gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
CPZ for domains           About GeneDecksing

4 InterPro domains/families:
 IPR008969 CarboxyPept-like_regulatory
 IPR020067 Frizzled_dom
 IPR014766 CarboxyPept_regulatory_dom
 IPR000834 Peptidase_M14

Graphical View of Domain Structure for InterPro Entry Q66K79

ProtoNet protein and cluster: Q66K79

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Similarity: Belongs to the peptidase M14 family
Similarity: Contains 1 FZ (frizzled) domain


Function
for CPZ gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by
cleaving some undefined protein. May play a role in cleavage during prohormone processing
Enzyme regulation: Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and
guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA
Biophysicochemical properties: Kinetic parameters: KM=2 mM for dansyl-Phe-Ala-Arg; KM=2 mM for dansyl-Pro-Ala-Arg; pH
dependence: Optimum pH is 7.8;

Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.102 EC 3.4.17.32 EC 3.4.17.-1

miRNA
Products:    		 OriGene 3'-UTR Clone (see all 3): CPZ
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPZ
1 QIAGEN miScript miRNA Assays for microRNA that regulate CPZ:
hsa-miR-335
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPZ (see all 6)
OriGene shRNA RFP: CPZ
OriGene siRNA: CPZ
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPZ

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for CPZ

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPZ (see all 5)
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GenScript: all cDNA clones in your preferred vector (see all 3): CPZ (NM_001014447)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPZ
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPZ 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for CPZ
Search LifeMap BioReagents cell lines for CPZ

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPZ

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004181metallocarboxypeptidase activity IEA--
GO:0008270zinc ion binding IEA--


CPZ for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for CPZ:
 Decreased melanin production 


Pathways & Interactions
for CPZ gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPZ

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0016055Wnt receptor signaling pathway IEA--


CPZ for ontologies           About GeneDecksing



Drugs & Compounds
for CPZ gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CPZ
Search CenterWatch for drugs/clinical trials and news about CPZ / CBPZ 

Transcripts
for CPZ gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for CPZ gene (3 alternative transcripts): 
NM_001014447.2  NM_001014448.2  NM_003652.3  

Unigene Cluster for CPZ:

Carboxypeptidase Z
Hs.61995  [show with all ESTs]
Unigene Representative Sequence: NM_001014448
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360986(uc003glm.3 uc003glo.3) ENST00000506287 ENST00000504070
ENST00000511057 ENST00000515606 ENST00000315782 ENST00000514602 ENST00000514875
ENST00000513486 ENST00000382480(uc003gln.3) ENST00000429646

miRNA
Products:     		 OriGene 3'-UTR Clone (see all 3): CPZ
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPZ
1 QIAGEN miScript miRNA Assays for microRNA that regulate CPZ:
hsa-miR-335
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPZ (see all 6)
OriGene shRNA RFP: CPZ
OriGene siRNA: CPZ
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPZ
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPZ (see all 4)
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GenScript: all cDNA clones in your preferred vector (see all 3): CPZ (NM_001014447)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPZ
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPZ 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPZ
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPZ

Additional cDNA sequence: 

AK056317.1 BC006393.2 BC018913.2 BC080539.1 U83411.1 

12 DOTS entries:

DT.97794433  DT.444024  DT.95369589  DT.100701339  DT.100020696  DT.92420889  DT.121255963  DT.102826056 
DT.95287956  DT.100785282  DT.95369587  DT.91809445 

24/110 AceView cDNA sequences (see all 110):

AU102221 BC018913 AA242820 CA431308 AI270606 BP374768 CA422568 BM666506 
CD652870 BX459172 AK127844 BX352105 BX417997 BI113847 CR611914 BU741581 
BX340104 AA242955 BC080539 AA335964 AA427724 AW952585 CA413810 BP375058 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CPZ (see all 10)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1:                          -                 -                       -                             -                 -                           
SP2:                          -     -     -     -     -                 -                             -                 -                           
SP3:                                      -     -     -                 -                             -                 -                           
SP4:                                                                                                                    -                           
SP5:                                                                                                                                                


ECgene alternative splicing isoforms for CPZ

Expression
for CPZ gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CPZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGCGGAG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

CPZ expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
BoneZeugopod PeriosteumBone
LimbLimb BudLimb
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells 
NameCategory
PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
PureStem™ progenitor T42 (Embryonic Progenitor Cell)
PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
Definitive endoderm-like cells (A scalable, suspensi...)

See CPZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPZ

SOURCE GeneReport for Unigene cluster: Hs.61995

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Tissue specificity: In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space.
Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in
normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein
level). Widely expressed

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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPZ

Orthologs
for CPZ gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of eukaryotes.

Orthologs for CPZ gene from 7/25 species (see all 25)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves CPZ1 carboxypeptidase Z 65.77(n)
66.77(a)		   395266  NM_204578.1  NP_989909.1 
lizard
(Anolis carolinensis)		 Reptilia --
--
(see all 3)		 --
 65(a)
55(a)
(see all 3)		 1 ↔ many
1 ↔ many
(see all 3)		 GL343236.1(1774354-1814755)
AAWZ02036718(15114-20008)
tropical clawed frog
(Xenopus tropicalis)		 Amphibia Str.120002 Transcribed sequence with weak similarity to protein more 78.56(n)    BX714479.1 
zebrafish
(Danio rerio)		 Actinopterygii cpz1 carboxypeptidase Z 61.06(n)
58.02(a)		   557534  XM_680621.3  XP_685713.3 
fruit fly
(Drosophila melanogaster)		 Insecta svr6
 silver
 12(a)
 possible ortholog
 X(390504-403113)
thale cress
(Arabidopsis thaliana)		 eudicotyledons SOL16
 putative carboxypeptidase D
 28(a)
 1 → many
 1(26966887-26970572)
rice
(Oryza sativa)		 Liliopsida --
 zinc carboxypeptidase family protein, putative, ex...
 34(a)
 1 → many
 6(2357309-2364541)


ENSEMBL Gene Tree for CPZ (if available)
TreeFam Gene Tree for CPZ (if available) 

Paralogs
for CPZ gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CPZ gene
CPE2  CPXM22  AEBP12  CPN12  CPD2  CPM2  CPXM12  
6 SIMAP similar genes for CPZ using alignment to 3 protein entries:     CBPZ_HUMAN (see all proteins):
CPN1    CPE    CPXM2    DKFZp666J235    CPXM1    CPM

CPZ for paralogs           About GeneDecksing



Genomic Variants
for CPZ gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CPZ
     11 CNVs: 36307 7455 30201 80180 91920 36305 3479 30202 36306 4377 91921
Human Gene Mutation Database (HGMD): CPZ
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPZ
DNA2.0 Custom Variant and Variant Library Synthesis for CPZ

Disorders / Diseases
for CPZ gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
CPZ for disorders           About GeneDecksing

OMIM gene information: 603105    OMIM disorders: --

5 diseases for CPZ:    About MalaCards
intestinal volvulus    sleeping sickness    monkeypox    pituitary adenoma
adenoma

1 disease from the University of Copenhagen DISEASES database for CPZ:
Sleeping sickness

1 Novoseek disease relationship for CPZ gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma 24.7 1 10671522 (1)

Human Genome Epidemiology (HuGE) Navigator: CPZ (2 documents)

Export disorders for CPZ gene to outside databases

Publications
for CPZ gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CPZ gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CPZ)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. (PubMed id 9099699)1, 2, 3, 9 Song L. and Fricker L.D. (1997)
  2. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. (PubMed id 10671522)1, 2, 9 Novikova E.G.... Fricker L.D. (2000)
  3. Purification and characterization of human metallocarboxypeptidase Z. (PubMed id 10080937)1, 2, 9 Novikova E.G. and Fricker L.D. (1999)
  4. Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding. (PubMed id 11766880)1, 2, 9 Reznik S.E. and Fricker L.D. (2001)
  5. Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. (PubMed id 12417617)1, 2, 9 Fan X.... Johnson M.D. (2002)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

External Searches for CPZ gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing CPZ gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8532 HGNC: 2333 AceView: CPZ Ensembl:ENSG00000109625 euGenes: HUgn8532
ECgene: CPZ H-InvDB: CPZ

Other Databases showing CPZ gene

(According to HUGE)
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Specialized Databases showing CPZ gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CPZ Pharmacogenomics, SNPs, Pathways

Intellectual Property
for CPZ gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPZ gene:
Search GeneIP for patents involving CPZ

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for CPZ gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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