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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPZ Gene

protein-coding   GIFtS: 56
GCID: GC04P008583

Carboxypeptidase Z

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase Z1 2
Metallocarboxypeptidase Z1 2
EC 3.4.17.-3
EC 3.4.178
EC 3.4.17.108
EC 3.4.17.38

External Ids:    HGNC: 23331   Entrez Gene: 85322   Ensembl: ENSG000001096257   OMIM: 6031055   UniProtKB: Q66K793   

Export aliases for CPZ gene to outside databases

Previous GC identifers: GC04P008774 GC04P008786 GC04P008712


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPZ Gene:
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity
towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active
site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPZ Gene: 
CPZ (carboxypeptidase Z) is a protein-coding gene. Diseases associated with CPZ include monkeypox, and sleeping sickness. GO annotations related to this gene include metallocarboxypeptidase activity and zinc ion binding. An important paralog of this gene is CPE.

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by
cleaving some undefined protein. May play a role in cleavage during prohormone processing

Gene Wiki entry for CPZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPZ gene promoter:
         AREB6   NRSF form 1   MyoD   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPZ promoter sequence
   Search SABiosciences Chromatin IP Primers for CPZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

CPZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPZ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P008583:  view genomic region     (about GC identifiers)

Start:
8,594,387 bp from pter      End:
8,621,488 bp from pter
Size:
27,102 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79 (See protein sequence)
Recommended Name: Carboxypeptidase Z precursor  
Size: 652 amino acids; 73655 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=BAB71147.1; Type=Frameshift; Positions=358;
Secondary accessions: O00520 Q96MX2
Alternative splicing: 3 isoforms:  Q66K79-1   Q66K79-2   Q66K79-3   

Explore the universe of human proteins at neXtProt for CPZ: NX_Q66K79

Explore proteomics data for CPZ at MOPED 

4/12 DME Specific Peptides for CPZ (Q66K79) (see all 12)
 GDYWRLL  IPFVLSA  EGAGYNGW  WYSFTGGM 

CPZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CPZ Protein Expression
REFSEQ proteins (3 alternative transcripts): 
NP_001014447.1  NP_001014448.1  NP_003643.2  

ENSEMBL proteins: 
 ENSP00000354255   ENSP00000422693   ENSP00000315074   ENSP00000371920   ENSP00000403981  

Human Recombinant Protein Products for CPZ: 
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OriGene Protein Over-expression Lysate for CPZ
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Novus Biologicals CPZ Lysates
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Cloud-Clone Corp. Proteins for CPZ 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IEA--

CPZ for ontologies           About GeneDecksing



CPZ Antibody Products: 
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Cloud-Clone Corp. CLIAs for CPZ


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase Z 
Metallocarboxypeptidases

4 InterPro protein domains:
 IPR008969 CarboxyPept-like_regulatory
 IPR020067 Frizzled_dom
 IPR014766 CarboxyPept_regulatory_dom
 IPR000834 Peptidase_M14

Graphical View of Domain Structure for InterPro Entry Q66K79

ProtoNet protein and cluster: Q66K79

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Similarity: Belongs to the peptidase M14 family
Similarity: Contains 1 FZ (frizzled) domain


CPZ for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CBPZ_HUMAN, Q66K79
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by
cleaving some undefined protein. May play a role in cleavage during prohormone processing
Enzyme regulation: Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and
guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA
Biophysicochemical properties: Kinetic parameters: KM=2 mM for dansyl-Phe-Ala-Arg; KM=2 mM for dansyl-Pro-Ala-Arg;
pH dependence: Optimum pH is 7.8;

     Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.102 EC 3.4.17.32 EC 3.4.17.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004181metallocarboxypeptidase activity IEA--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
CPZ for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CPZ:
 Decreased melanin production 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CPZ 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPZ

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPZ 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPZ 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPZ
1 QIAGEN miScript miRNA Assays for microRNA that regulate CPZ:
hsa-miR-335
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Inhib. RNA
Products:
    
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPZ

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of CPZ

Clone
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OriGene ORF clones in mouse, rat for CPZ
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): CPZ (NM_001014447)
Sino Biological Human cDNA Clone for CPZ
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPZ
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPZ
Sirion Biotech Customized lentivirus for stable overexpression of CPZ 
                     Customized lentivirus expression plasmids for stable overexpression of CPZ 

Cell Line
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GenScript Custom overexpressing Cell Line Services for CPZ
Search LifeMap BioReagents cell lines for CPZ
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPZ


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPZ

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0016055Wnt receptor signaling pathway IEA--

CPZ for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CPZ (CBPZ)

Search CenterWatch for drugs/clinical trials and news about CPZ / CBPZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CPZ gene (3 alternative transcripts): 
NM_001014447.2  NM_001014448.2  NM_003652.3  

Unigene Cluster for CPZ:

Carboxypeptidase Z
Hs.61995  [show with all ESTs]
Unigene Representative Sequence: NM_001014448
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360986(uc003glm.3 uc003glo.3) ENST00000506287 ENST00000515606
ENST00000315782 ENST00000514602 ENST00000504070 ENST00000514875 ENST00000513486
ENST00000382480(uc003gln.3) ENST00000429646
miRNA
Products:
     
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1 QIAGEN miScript miRNA Assays for microRNA that regulate CPZ:
hsa-miR-335
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CPZ
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Clone
Products:
     
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GenScript: all cDNA clones in your preferred vector (see all 3): CPZ (NM_001014447)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPZ
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPZ
Sirion Biotech Customized lentivirus for stable overexpression of CPZ 
                     Customized lentivirus expression plasmids for stable overexpression of CPZ 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CPZ
OriGene qSTAR qPCR primer pairs in human, mouse for CPZ
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPZ
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPZ
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPZ

Additional mRNA sequence: 

AK056317.1 BC006393.2 BC018913.2 BC080539.1 U83411.1 

12 DOTS entries:

DT.97794433  DT.444024  DT.95369589  DT.100701339  DT.100020696  DT.92420889  DT.121255963  DT.102826056 
DT.95287956  DT.100785282  DT.95369587  DT.91809445 

24/110 AceView cDNA sequences (see all 110):

AU102221 BX340104 AI270606 CA431308 BC018913 AA242820 BP374768 CA422568 
BX459172 BM666506 BX352105 BX417997 AK127844 CD652870 AU279762 BQ016849 
BM476863 AW262754 AL541859 BM695616 AI131477 BP372791 AK056317 BC006393 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CPZ (see all 10)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1:                          -                 -                       -                             -                 -                           
SP2:                          -     -     -     -     -                 -                             -                 -                           
SP3:                                      -     -     -                 -                             -                 -                           
SP4:                                                                                                                    -                           
SP5:                                                                                                                                                


ECgene alternative splicing isoforms for CPZ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CPZ expression in normal human tissues (normalized intensities)      CPZ embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCTGCGGAG
CPZ Expression
About this image


CPZ expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/19 selected tissues (see all 19) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         Membranous Facial Bones
         sensory organ/ear/inner ear   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
         Normal Human Articular chondrocytes (NHAC)   
         skeleton/cranium   
 
 Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
         Foregut
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         limb/hindlimb   
 
 Eye (Sensory Organs)
         Retina

See CPZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPZ

SOURCE GeneReport for Unigene cluster: Hs.61995

UniProtKB/Swiss-Prot: CBPZ_HUMAN, Q66K79
Tissue specificity: In placenta, it is present within invasive trophoblasts and in the surrounding extracellular
space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type.
Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing
adenomas) (at protein level). Widely expressed

    SABiosciences Custom PCR Arrays for CPZ
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPZ
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPZ

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CPZ gene from 5/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cpz1 , 5 carboxypeptidase Z1, 5 81.81(n)1
82.48(a)1
  5 (18.16 cM)5
2429391  NM_153107.21  NP_694747.21 
 355022155 
chicken
(Gallus gallus)
Aves CPZ1 carboxypeptidase Z 65.77(n)
66.77(a)
  395266  NM_204578.1  NP_989909.1 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
67(a)
54(a)
1 ↔ many
1 ↔ many
GL343236.1(1774354-1815170)
AAWZ02036718(14889-21479)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.120002 Transcribed sequence with weak similarity to protein more 78.56(n)    BX714479.1 
zebrafish
(Danio rerio)
Actinopterygii cpz1 carboxypeptidase Z 61.06(n)
58.02(a)
  557534  XM_680621.3  XP_685713.3 


ENSEMBL Gene Tree for CPZ (if available)
TreeFam Gene Tree for CPZ (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CPZ gene
CPE2  CPXM22  AEBP12  CPN12  CPD2  CPM2  CPXM12  
6 SIMAP similar genes for CPZ using alignment to 3 protein entries:     CBPZ_HUMAN (see all proteins):
CPN1    CPE    CPXM2    DKFZp666J235    CPXM1    CPM

CPZ for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1467 SNPs in CPZ are shown (see all 1467)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1490595531,2
C,Funtested18583721(+) TCATCC/TGCTTC 6 R C mis11Minor allele frequency- T:0.00NA 4312
rs2020922741,2
Cuntested18585722(+) GCAACA/GAGGTG 6 K E mis10--------
VAR_0472464
----see VAR_0472462 I T mis40--------
rs783434711,2
C,F--8570353(+) ACCCAC/TCCTCC 3 -- us2k11Minor allele frequency- T:0.04WA 118
rs37561801,2
C,F--8570556(-) GGGGAG/TAGGCC 3 -- us2k12Minor allele frequency- T:0.16EA 1582
rs1809010521,2
--8570594(+) CTCTTC/GGTACT 3 -- us2k10--------
rs1863110421,2
--8570641(+) CTGAGA/GCAGAC 3 -- us2k10--------
rs595386341,2
C,F--8570657(+) CCTCCC/GTCCTC 3 -- us2k12Minor allele frequency- G:0.03WA 120
rs37561791,2
C,F,A,H--8570672(-) GGGCTG/ATGAGC 3 -- us2k117Minor allele frequency- A:0.35NS EA NA WA CSA 977
rs1903669011,2
--8570696(+) TCAAGA/GGTCCA 3 -- us2k10--------

HapMap Linkage Disequilibrium report for CPZ (8594387 - 8621488 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/17 variations for CPZ (see all 17):    About this table     
Variant IDTypeSubtypePubMed ID
nsv4225CNV Insertion18451855
nsv878618CNV Loss21882294
dgv5461n71CNV Loss21882294
nsv518282CNV Loss19592680
dgv5460n71CNV Loss21882294
nsv470015CNV Loss18288195
nsv4226CNV Loss18451855
nsv521867CNV Loss19592680
nsv10442CNV Gain18304495
nsv878612CNV Gain21882294


Human Gene Mutation Database (HGMD): CPZ
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CPZ
DNA2.0 Custom Variant and Variant Library Synthesis for CPZ

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603105    OMIM disorders: --

5 diseases for CPZ:    About MalaCards
monkeypox    sleeping sickness    intestinal volvulus    pituitary adenoma
adenoma

2 diseases from the University of Copenhagen DISEASES database for CPZ:
Yaws     Sleeping sickness

CPZ for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for CPZ gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma 24.7 1 10671522 (1)

Genetic Association Database (GAD): CPZ
Human Genome Epidemiology (HuGE) Navigator: CPZ (2 documents)

Export disorders for CPZ gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CPZ gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CPZ)
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  1. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. (PubMed id 9099699)1, 2, 3, 9 Song L. and Fricker L.D. (1997)
  2. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. (PubMed id 10671522)1, 2, 9 Novikova E.G.... Fricker L.D. (2000)
  3. Purification and characterization of human metallocarboxypeptidase Z. (PubMed id 10080937)1, 2, 9 Novikova E.G. and Fricker L.D. (1999)
  4. Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding. (PubMed id 11766880)1, 2, 9 Reznik S.E. and Fricker L.D. (2001)
  5. Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. (PubMed id 12417617)1, 2, 9 Fan X.... Johnson M.D. (2002)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8532 HGNC: 2333 AceView: CPZ Ensembl:ENSG00000109625 euGenes: HUgn8532
ECgene: CPZ H-InvDB: CPZ

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CPZ Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPZ gene:
Search GeneIP for patents involving CPZ

GeneCards and IP:
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