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Aliases for CPXM2 Gene

Aliases for CPXM2 Gene

  • Carboxypeptidase X (M14 Family), Member 2 2 3
  • Cytosolic Carboxypeptidase 2 3
  • Carboxypeptidase-Like Protein X2 3
  • Carboxypeptidase Hlo 3
  • 4632435C11Rik 3
  • EC 3.4.17.3 63
  • EC 3.4.17 63
  • UNQ676 3
  • CPX2 3

External Ids for CPXM2 Gene

Previous GeneCards Identifiers for CPXM2 Gene

  • GC10M125495
  • GC10M125462
  • GC10M119120

Summaries for CPXM2 Gene

GeneCards Summary for CPXM2 Gene

CPXM2 (Carboxypeptidase X (M14 Family), Member 2) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for CPXM2 Gene

  • May be involved in cell-cell interactions

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXM2 Gene

Genomics for CPXM2 Gene

Regulatory Elements for CPXM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPXM2 Gene

Chromosome:
10
Start:
123,706,207 bp from pter
End:
123,940,267 bp from pter
Size:
234,061 bases
Orientation:
Minus strand

Genomic View for CPXM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPXM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM2 Gene

Proteins for CPXM2 Gene

  • Protein details for CPXM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N436-CPXM2_HUMAN
    Recommended name:
    Inactive carboxypeptidase-like protein X2
    Protein Accession:
    Q8N436
    Secondary Accessions:
    • B4E3Q2

    Protein attributes for CPXM2 Gene

    Size:
    756 amino acids
    Molecular mass:
    85870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM2 Gene

Proteomics data for CPXM2 Gene at MOPED

Selected DME Specific Peptides for CPXM2 Gene

Post-translational modifications for CPXM2 Gene

  • Glycosylation at Asn 231, Asn 241, Asn 281, Asn 337, and Asn 491
  • Modification sites at PhosphoSitePlus

Other Protein References for CPXM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPXM2 Gene

Gene Families for CPXM2 Gene

Suggested Antigen Peptide Sequences for CPXM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N436

UniProtKB/Swiss-Prot:

CPXM2_HUMAN :
  • Contains 1 F5/8 type C domain.
  • Belongs to the peptidase M14 family.
Domain:
  • Contains 1 F5/8 type C domain.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPXM2: view

Function for CPXM2 Gene

Molecular function for CPXM2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interactions

Enzyme Numbers (IUBMB) for CPXM2 Gene

Gene Ontology (GO) - Molecular Function for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPXM2: view

Phenotypes for CPXM2 Gene

genes like me logo Genes that share phenotypes with CPXM2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPXM2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPXM2 Gene

Localization for CPXM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPXM2 Gene COMPARTMENTS Subcellular localization image for CPXM2 gene
Compartment Confidence
extracellular 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with CPXM2: view

Pathways & Interactions for CPXM2 Gene

SuperPathways for CPXM2 Gene

No Data Available

Interacting Proteins for CPXM2 Gene

Selected Interacting proteins: Q8N436-CPXM2_HUMAN for CPXM2 Gene via I2D

Symbol External ID(s) Details
SMAD9

Gene Ontology (GO) - Biological Process for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPXM2: view

No data available for Pathways by source and SIGNOR curated interactions for CPXM2 Gene

Drugs & Compounds for CPXM2 Gene

No Compound Related Data Available

Transcripts for CPXM2 Gene

Unigene Clusters for CPXM2 Gene

Carboxypeptidase X (M14 family), member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPXM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for CPXM2 Gene

GeneLoc Exon Structure for
CPXM2
ECgene alternative splicing isoforms for
CPXM2

Expression for CPXM2 Gene

mRNA expression in normal human tissues for CPXM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM2 Gene

This gene is overexpressed in Artery - Aorta (x10.7), Artery - Coronary (x6.3), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for CPXM2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (31.2) and Colon (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPXM2 Gene



SOURCE GeneReport for Unigene cluster for CPXM2 Gene Hs.656887

genes like me logo Genes that share expression patterns with CPXM2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CPXM2 Gene

Orthologs for CPXM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPXM2 35
  • 88.23 (n)
  • 90.34 (a)
CPXM2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPXM2 35
  • 89.16 (n)
  • 95.84 (a)
CPXM2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpxm2 35
  • 85.79 (n)
  • 90.19 (a)
Cpxm2 16
Cpxm2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPXM2 35
  • 99.23 (n)
  • 99.23 (a)
CPXM2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpxm2 35
  • 85.19 (n)
  • 89.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CPXM2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPXM2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPXM2 35
  • 75.8 (n)
  • 81.3 (a)
CPXM2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPXM2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpxm2 35
  • 71.11 (n)
  • 75.98 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC793308 35
  • 63.14 (n)
  • 61.34 (a)
CABZ01090975.1 36
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for CPXM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPXM2 Gene

ENSEMBL:
Gene Tree for CPXM2 (if available)
TreeFam:
Gene Tree for CPXM2 (if available)

Paralogs for CPXM2 Gene

Paralogs for CPXM2 Gene

(9) SIMAP similar genes for CPXM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPXM2: view

Variants for CPXM2 Gene

Sequence variations from dbSNP and Humsavar for CPXM2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8277 -- 123,745,885(-) CCCTG(C/T)GTGGA utr-variant-3-prime, intron-variant
rs9060 -- 123,745,937(-) AAAGA(A/G)CCAGA utr-variant-3-prime, intron-variant
rs727416 -- 123,771,230(-) AAAGT(A/G)GGCAT intron-variant
rs727417 -- 123,771,393(-) ttggg(C/G)attag intron-variant
rs735632 -- 123,743,948(+) GGCTC(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPXM2 Gene

Variant ID Type Subtype PubMed ID
nsv832011 CNV Gain+Loss 17160897
nsv25320 CNV Loss 16902084
esv2220029 CNV Deletion 18987734
esv2742506 CNV Deletion 23290073
nsv820023 CNV Loss 19587683
esv2742517 CNV Deletion 23290073
esv2742528 CNV Deletion 23290073
esv2742539 CNV Deletion 23290073
esv2742550 CNV Deletion 23290073
esv27822 CNV Loss 19812545

Variation tolerance for CPXM2 Gene

Residual Variation Intolerance Score: 80.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPXM2 Gene

HapMap Linkage Disequilibrium report
CPXM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXM2 Gene

Disorders for CPXM2 Gene

Relevant External Links for CPXM2

Genetic Association Database (GAD)
CPXM2
Human Genome Epidemiology (HuGE) Navigator
CPXM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPXM2
genes like me logo Genes that share disorders with CPXM2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPXM2 Gene

Publications for CPXM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  2. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. (PMID: 25082827) JuliA A. … Marsal S. (Hum. Mol. Genet. 2014) 67
  3. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M. … . (Thorax 2011) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Proteomics characterization of extracellular space components in the human aorta. (PMID: 20551380) Didangelos A. … Mayr M. (Mol. Cell. Proteomics 2010) 67

Products for CPXM2 Gene

Sources for CPXM2 Gene

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