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Aliases for CPXM1 Gene

Aliases for CPXM1 Gene

  • Carboxypeptidase X (M14 Family), Member 1 2 3
  • Carboxypeptidase-Like Protein X1 2 3
  • Metallocarboxypeptidase CPX-1 3 4
  • CPXM 3 4
  • CPX1 3 4
  • Carboxypeptidase X (M14 Family) 2
  • Probable Carboxypeptidase X1 3
  • EC 3.4.17.10 64
  • EC 3.4.17.3 64
  • EC 3.4.17.- 4
  • EC 3.4.17 64

External Ids for CPXM1 Gene

Previous Symbols for CPXM1 Gene

  • CPXM

Summaries for CPXM1 Gene

Entrez Gene Summary for CPXM1 Gene

  • This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]

GeneCards Summary for CPXM1 Gene

CPXM1 (Carboxypeptidase X (M14 Family), Member 1) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for CPXM1 Gene

  • May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Gene Wiki entry for CPXM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXM1 Gene

Genomics for CPXM1 Gene

Genomic Location for CPXM1 Gene

Start:
2,794,069 bp from pter
End:
2,800,646 bp from pter
Size:
6,578 bases
Orientation:
Minus strand

Genomic View for CPXM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPXM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM1 Gene

Regulatory Elements for CPXM1 Gene

Proteins for CPXM1 Gene

  • Protein details for CPXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SM3-CPXM1_HUMAN
    Recommended name:
    Probable carboxypeptidase X1
    Protein Accession:
    Q96SM3
    Secondary Accessions:
    • Q6P4G8
    • Q6UW65
    • Q9NUB5

    Protein attributes for CPXM1 Gene

    Size:
    734 amino acids
    Molecular mass:
    81668 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM1 Gene

Proteomics data for CPXM1 Gene at MOPED

Selected DME Specific Peptides for CPXM1 Gene

Post-translational modifications for CPXM1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57, Asn210, Asn220, Asn318, Asn428, and Asn472

Other Protein References for CPXM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CPXM1 Gene

UniProtKB/Swiss-Prot:

CPXM1_HUMAN
Domain:
  • Contains 1 F5/8 type C domain.:
    • Q96SM3
Family:
  • Belongs to the peptidase M14 family.:
    • Q96SM3
genes like me logo Genes that share domains with CPXM1: view

Function for CPXM1 Gene

Molecular function for CPXM1 Gene

UniProtKB/Swiss-Prot Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Enzyme Numbers (IUBMB) for CPXM1 Gene

Gene Ontology (GO) - Molecular Function for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPXM1: view

Phenotypes for CPXM1 Gene

GenomeRNAi human phenotypes for CPXM1:
genes like me logo Genes that share phenotypes with CPXM1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPXM1 Gene

Localization for CPXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPXM1 Gene COMPARTMENTS Subcellular localization image for CPXM1 gene
Compartment Confidence
extracellular 2

Gene Ontology (GO) - Cellular Components for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CPXM1: view

Pathways for CPXM1 Gene

SuperPathways for CPXM1 Gene

No Data Available

Interacting Proteins for CPXM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369979%0d%0a9606.ENSP00000263025%0d%0a9606.ENSP00000278360%0d%0a
Selected Interacting proteins: ENSP00000369979 Q96SM3-CPXM1_HUMAN for CPXM1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion --
genes like me logo Genes that share ontologies with CPXM1: view

No data available for Pathways by source for CPXM1 Gene

Transcripts for CPXM1 Gene

mRNA/cDNA for CPXM1 Gene

Unigene Clusters for CPXM1 Gene

Carboxypeptidase X (M14 family), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for CPXM1 Gene

GeneLoc Exon Structure for
CPXM1
ECgene alternative splicing isoforms for
CPXM1

Expression for CPXM1 Gene

mRNA expression in normal human tissues for CPXM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM1 Gene

This gene is overexpressed in Cervix - Ectocervix (7.1), Adipose - Visceral (Omentum) (5.8), Uterus (5.2), and Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPXM1 Gene

SOURCE GeneReport for Unigene cluster for CPXM1 Gene Hs.659346

genes like me logo Genes that share expressions with CPXM1: view

Orthologs for CPXM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPXM1 36
  • 97.12 (n)
  • 95.75 (a)
CPXM1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPXM1 36
  • 88.04 (n)
  • 88.49 (a)
CPXM1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPXM1 36
  • 86.64 (n)
  • 87.69 (a)
CPXM1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpxm1 36
  • 84.21 (n)
  • 86.29 (a)
Cpxm1 16
Cpxm1 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPXM1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPXM1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpxm1 36
  • 83.84 (n)
  • 87.12 (a)
chicken
(Gallus gallus)
Aves CPXM1 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPXM1 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpxm1 36
  • 65.83 (n)
  • 65.93 (a)
Str.17581 36
zebrafish
(Danio rerio)
Actinopterygii CPXM1 (1 of 2) 37
  • 55 (a)
OneToMany
CU469518.1 37
  • 42 (a)
OneToMany
si:dkey-19p15.7 36
  • 64.24 (n)
  • 64.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for CPXM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPXM1 Gene

ENSEMBL:
Gene Tree for CPXM1 (if available)
TreeFam:
Gene Tree for CPXM1 (if available)

Paralogs for CPXM1 Gene

Paralogs for CPXM1 Gene

Selected SIMAP similar genes for CPXM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPXM1: view

Variants for CPXM1 Gene

Sequence variations from dbSNP and Humsavar for CPXM1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs127076 -- 2,797,429(-) ACAGT(A/G)AGCTT intron-variant
rs127078 -- 2,794,686(-) AGCAC(A/G)TTATC intron-variant
rs215537 -- 2,793,959(+) CAATG(C/T)GTCCA downstream-variant-500B
rs215538 -- 2,793,983(+) GAGAG(A/T)GTGCA downstream-variant-500B
rs215539 -- 2,794,037(+) CGGGG(A/G)GAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CPXM1 Gene

Variant ID Type Subtype PubMed ID
nsv833895 CNV Loss 17160897
nsv522009 CNV Gain 19592680
nsv510780 CNV Loss 20534489

Relevant External Links for CPXM1 Gene

HapMap Linkage Disequilibrium report
CPXM1

Disorders for CPXM1 Gene

(1) University of Copenhagen DISEASES for CPXM1 Gene

genes like me logo Genes that share disorders with CPXM1: view

No data available for UniProtKB/Swiss-Prot for CPXM1 Gene

Publications for CPXM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CPXM1 Gene

Sources for CPXM1 Gene

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