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CPXM1 Gene

protein-coding   GIFtS: 52
GCID: GC20M002723

Carboxypeptidase X (M14 Family), Member 1

(Previous name: carboxypeptidase X (M14 family))
(Previous symbol: CPXM)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase X (M14 Family), Member 11 2     Probable Carboxypeptidase X12
CPXM1 2 3     EC 3.4.17.-3
Carboxypeptidase-Like Protein X11 2     EC 3.4.178
Metallocarboxypeptidase CPX-12 3     EC 3.4.17.108
CPX12 3     EC 3.4.17.38
Carboxypeptidase X (M14 Family)1     

External Ids:    HGNC: 157711   Entrez Gene: 562652   Ensembl: ENSG000000888827   OMIM: 6095555   UniProtKB: Q96SM33   

Export aliases for CPXM1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPXM1 Gene:
This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in
mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the
protein appears to lack residues necessary for carboxypeptidase activity.(provided by RefSeq, May 2010)

GeneCards Summary for CPXM1 Gene:
CPXM1 (carboxypeptidase X (M14 family), member 1) is a protein-coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3
Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity)

Gene Wiki entry for CPXM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPXM1 gene promoter:
         ER-alpha   Pax-6   XBP-1   Ik-3   E47   GATA-1   C/EBPalpha   Egr-2   MRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPXM1 promoter sequence
   Search Chromatin IP Primers for CPXM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPXM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CPXM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPXM1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M002723:  view genomic region     (about GC identifiers)

Start:
2,774,715 bp from pter      End:
2,781,292 bp from pter
Size:
6,578 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3 (See protein sequence)
Recommended Name: Probable carboxypeptidase X1 precursor  
Size: 734 amino acids; 81668 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q6P4G8 Q6UW65 Q9NUB5

Explore the universe of human proteins at neXtProt for CPXM1: NX_Q96SM3

Explore proteomics data for CPXM1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn210, Asn220, Asn318, Asn428, Asn472
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CPXM1 (Q96SM3) (see all 8)
     GINHDVT  GDYWRLL  IPFVLSA  ELSCDKFP 


    See CPXM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171628.1  NP_062555.1  

    ENSEMBL proteins: 
     ENSP00000369979  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CPXM1 (4 products) 

     
    antibodies-online peptides for CPXM1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase X (M14 family), member 1
    Metallocarboxypeptidases

    5 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR008979 Galactose-bd-like
     IPR000834 Peptidase_M14
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry Q96SM3

    ProtoNet protein and cluster: Q96SM3

    1 Blocks protein domain: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

    UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3
    Similarity: Belongs to the peptidase M14 family
    Similarity: Contains 1 F5/8 type C domain


    Find genes that share domains with CPXM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPXM1_HUMAN, Q96SM3
    Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.32 EC 3.4.17.102 EC 3.4.17.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CPXM1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CPXM1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CPXM1

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    hsa-miR-596
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPXM1_HUMAN, Q96SM3: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CPXM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPXM1
    Interactions:

        Search GeneGlobe Interaction Network for CPXM1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CPXM1 (Q96SM33 ENSP000003699794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with CPXM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPXM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPXM1 gene (2 alternative transcripts): 
    NM_001184699.1  NM_019609.4  

    Unigene Cluster for CPXM1:

    Carboxypeptidase X (M14 family), member 1
    Hs.659346  [show with all ESTs]
    Unigene Representative Sequence: BC063430
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380605(uc010gas.3 uc002wgu.3)
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    hsa-miR-596
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    Additional mRNA sequence: 

    AK027661.1 AK075508.1 AK075527.1 AK303142.1 AK315027.1 AY358956.1 BC063430.1 

    10 DOTS entries:

    DT.101975031  DT.309737  DT.120800017  DT.120800070  DT.120800046  DT.120800173  DT.75164890  DT.86996255 
    DT.97821517  DT.102839092 

    Selected AceView cDNA sequences (see all 66):

    BQ671780 BF530379 AY358956 CR621966 AK075527 AI783636 BU683257 BC032692 
    D78784 BC063430 AK027661 NM_019609 AK075508 BE858065 AL559874 BX644074 
    BM727971 BX460533 BX366559 BX335102 CA310165 BQ069335 BQ672628 AA136113 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                                        -                                                                           
    SP2:                                                        -                                         -     -                           
    SP3:                                                        -                                                                           
    SP4:                                                  -     -                                                                           
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for CPXM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPXM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPXM1 Expression
    About this image


    CPXM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Lens
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Kidney (Urinary System)
             Metanephros
    CPXM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPXM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659346
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CPXM1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpxm11 , 5 carboxypeptidase X 1 (M14 family)1, 5 84.21(n)1
    86.29(a)1
      2 (63.22 cM)5
    562641  NM_019696.21  NP_062670.21 
     1303907755 
    chicken
    (Gallus gallus)
    Aves CPXM16
    carboxypeptidase X (M14 family), member 1
    65(a)
    1 ↔ 1
    AADN03018085.1(305-1213)
    lizard
    (Anolis carolinensis)
    Reptilia CPXM16
    carboxypeptidase X (M14 family), member 1
    59(a)
    1 ↔ 1
    GL343698.1(53176-113460)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175812 Transcribed sequence with weak similarity to protein more 74.15(n)    BX757076.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-19p15.71 si:dkey-19p15.7 64.24(n)
    64.57(a)
      564830  XM_688164.5  XP_693256.4 


    ENSEMBL Gene Tree for CPXM1 (if available)
    TreeFam Gene Tree for CPXM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPXM1 gene
    CPZ2  CPE2  CPXM22  AEBP12  CPN12  CPD2  CPM2  
    7 SIMAP similar genes for CPXM1 using alignment to 1 protein entry:     CPXM1_HUMAN:
    DKFZp666J235    CPXM2    AEBP1    CPE    CPN1    CPZ
    CPM

    Find genes that share paralogs with CPXM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPXM1 (see all 341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800417641,2
    F--2774277(+) TTCTAT/CTGCAT 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1145212101,2
    C,F--2774300(+) CAGTCC/TTGTTG 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1884356141,2
    --2774357(+) GGCACA/CTGGCC 2 -- ds50010--------
    rs1819117511,2
    --2774457(+) ATTCCC/TTGCAC 2 -- ds50010--------
    rs1862895611,2
    --2774517(+) TACCTA/GTAGCA 2 -- ds50010--------
    rs735840331,2
    C,F--2774562(+) GCCCTT/CGGTTC 2 -- ds50012Minor allele frequency- C:0.03WA 120
    rs2155371,2
    C,F,A--2774605(+) CAATGT/CGTCCA 2 -- ds50014Minor allele frequency- C:0.03MN NA 308
    rs2155381,2
    C,F,A--2774629(+) GAGAGT/AGTGCA 2 -- ds50019Minor allele frequency- A:0.32EA MN NA WA CSA 2052
    rs1128849561,2
    C,F--2774639(+) AAGTGT/CGCAGA 2 -- ds50014Minor allele frequency- C:0.13WA CSA 124
    rs758056251,2
    C,F--2774666(+) GGGCCG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for CPXM1 (2774715 - 2781292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPXM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833895CNV Loss17160897
    nsv510780CNV Loss20534489
    nsv522009CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPXM1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609555    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CPXM1:
    Lymphedema

    Find genes that share disorders with CPXM1           About GenesLikeMe


    Export disorders for CPXM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPXM1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CPXM1)
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    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (J. Proteome Res. 2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    8. An unappreciated role for RNA surveillance. (PubMed id 14759258)1 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2. (PubMed id 10073577)1 Lei Y....Fricker L.D. (DNA Cell Biol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56265 HGNC: 15771 AceView: CPXM Ensembl:ENSG00000088882 euGenes: HUgn56265
    ECgene: CPXM1 H-InvDB: CPXM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPXM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPXM1 gene:
    Search GeneIP for patents involving CPXM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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