Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPXM1 Gene

protein-coding   GIFtS: 52
GCID: GC20M002723

Carboxypeptidase X (M14 Family), Member 1

(Previous name: carboxypeptidase X (M14 family))
(Previous symbol: CPXM)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase X (M14 Family), Member 11 2     Probable Carboxypeptidase X12
CPXM1 2 3     EC 3.4.17.-3
Carboxypeptidase-Like Protein X11 2     EC 3.4.178
Metallocarboxypeptidase CPX-12 3     EC 3.4.17.108
CPX12 3     EC 3.4.17.38
Carboxypeptidase X (M14 Family)1     

External Ids:    HGNC: 157711   Entrez Gene: 562652   Ensembl: ENSG000000888827   OMIM: 6095555   UniProtKB: Q96SM33   

Export aliases for CPXM1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPXM1 Gene:
This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in
mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the
protein appears to lack residues necessary for carboxypeptidase activity.(provided by RefSeq, May 2010)

GeneCards Summary for CPXM1 Gene: 
CPXM1 (carboxypeptidase X (M14 family), member 1) is a protein-coding gene. Diseases associated with CPXM1 include lymphedema. GO annotations related to this gene include metallocarboxypeptidase activity and zinc ion binding. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3
Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity)

Gene Wiki entry for CPXM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPXM1 gene promoter:
         ER-alpha   Pax-6   XBP-1   Ik-3   E47   GATA-1   C/EBPalpha   Egr-2   MRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPXM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPXM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPXM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CPXM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPXM1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M002723:  view genomic region     (about GC identifiers)

Start:
2,774,715 bp from pter      End:
2,781,292 bp from pter
Size:
6,578 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3 (See protein sequence)
Recommended Name: Probable carboxypeptidase X1 precursor  
Size: 734 amino acids; 81668 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q6P4G8 Q6UW65 Q9NUB5

Explore the universe of human proteins at neXtProt for CPXM1: NX_Q96SM3

Explore proteomics data for CPXM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96SM3

  • 4/8 DME Specific Peptides for CPXM1 (Q96SM3) (see all 8)
     GINHDVT  GDYWRLL  IPFVLSA  ELSCDKFP 

    CPXM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPXM1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171628.1  NP_062555.1  

    ENSEMBL proteins: 
     ENSP00000369979  

    Human Recombinant Protein Products for CPXM1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CPXM1
    OriGene Protein Over-expression Lysate for CPXM1
    OriGene MassSpec for CPXM1 
    OriGene Custom Protein Services for CPXM1
    GenScript Custom Purified and Recombinant Proteins Services for CPXM1
    Novus Biologicals CPXM1 Proteins
    Novus Biologicals CPXM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CPXM1 for ontologies           About GeneDecksing



    CPXM1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CPXM1 (Carboxypeptidase X1/CPXM1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CPXM1
    GenScript Custom Superior Antibodies Services for CPXM1
    Novus Biologicals CPXM1 Antibodies
    Abcam antibodies for CPXM1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CPXM1
    LSBio Antibodies in human, mouse, rat for CPXM1 

    Assay Products for CPXM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CPXM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPXM1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase X (M14 family), member 1 
    Metallocarboxypeptidases

    5 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR008979 Galactose-bd-like
     IPR000834 Peptidase_M14
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry Q96SM3

    ProtoNet protein and cluster: Q96SM3

    1 Blocks protein domain: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

    UniProtKB/Swiss-Prot: CPXM1_HUMAN, Q96SM3
    Similarity: Belongs to the peptidase M14 family
    Similarity: Contains 1 F5/8 type C domain


    CPXM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPXM1_HUMAN, Q96SM3
    Function: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.32 EC 3.4.17.102 EC 3.4.17.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPXM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPXM1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPXM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPXM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPXM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPXM1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPXM1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPXM1:
    hsa-miR-596
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPXM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPXM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPXM1
    Sirion Biotech Customized adenovirus for overexpression of CPXM1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CPXM1 (see all 13)
    OriGene ORF clones in mouse, rat for CPXM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPXM1 (NM_001184699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPXM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPXM1
    Sirion Biotech Customized lentivirus for stable overexpression of CPXM1 
                         Customized lentivirus expression plasmids for stable overexpression of CPXM1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CPXM1
    Search LifeMap BioReagents cell lines for CPXM1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPXM1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CPXM1 (Q96SM33 ENSP000003699794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007155cell adhesion IEA--

    CPXM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPXM1

    Search CenterWatch for drugs/clinical trials and news about CPXM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPXM1 gene (2 alternative transcripts): 
    NM_001184699.1  NM_019609.4  

    Unigene Cluster for CPXM1:

    Carboxypeptidase X (M14 family), member 1
    Hs.659346  [show with all ESTs]
    Unigene Representative Sequence: BC063430
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380605(uc010gas.3 uc002wgu.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPXM1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPXM1:
    hsa-miR-596
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPXM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPXM1
    Clone
    Products:
         
    OriGene clones in human, mouse for CPXM1 (see all 13)
    OriGene ORF clones in mouse, rat for CPXM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPXM1 (NM_001184699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPXM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPXM1
    Sirion Biotech Customized lentivirus for stable overexpression of CPXM1 
                         Customized lentivirus expression plasmids for stable overexpression of CPXM1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPXM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CPXM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPXM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPXM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPXM1

    Additional mRNA sequence: 

    AK027661.1 AK075508.1 AK075527.1 AK303142.1 AK315027.1 AY358956.1 BC063430.1 

    10 DOTS entries:

    DT.101975031  DT.309737  DT.120800017  DT.120800070  DT.120800046  DT.120800173  DT.75164890  DT.86996255 
    DT.97821517  DT.102839092 

    24/66 AceView cDNA sequences (see all 66):

    D78784 BQ671780 AK075527 BF530379 AI783636 AY358956 BU683257 AK075508 
    CR621966 NM_019609 AK027661 BC063430 BC032692 BX366559 BM662810 BX361452 
    BF342099 BF341134 BQ672628 BU147502 BX644074 BM727971 BQ069335 BX460533 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                                        -                                                                           
    SP2:                                                        -                                         -     -                           
    SP3:                                                        -                                                                           
    SP4:                                                  -     -                                                                           
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for CPXM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPXM1 expression in normal human tissues (normalized intensities)      CPXM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPXM1 Expression
    About this image


    CPXM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
             brain/hindbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor SM22
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Retina
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier

    See CPXM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPXM1

    SOURCE GeneReport for Unigene cluster: Hs.659346
        SABiosciences Custom PCR Arrays for CPXM1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CPXM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CPXM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPXM1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPXM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPXM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CPXM1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpxm11 , 5 carboxypeptidase X 1 (M14 family)1, 5 84.21(n)1
    86.29(a)1
      2 (63.22 cM)5
    562641  NM_019696.21  NP_062670.21 
     1303907755 
    lizard
    (Anolis carolinensis)
    Reptilia CPXM16
    carboxypeptidase X (M14 family), member 1
    58(a)
    1 ↔ 1
    GL343698.1(53176-113460)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.175812 Transcribed sequence with weak similarity to protein more 74.15(n)    BX757076.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-19p15.71 si:dkey-19p15.7 63.53(n)
    63.8(a)
      564830  XM_688164.4  XP_693256.3 


    ENSEMBL Gene Tree for CPXM1 (if available)
    TreeFam Gene Tree for CPXM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPXM1 gene
    CPZ2  CPE2  CPXM22  AEBP12  CPN12  CPD2  CPM2  
    7 SIMAP similar genes for CPXM1 using alignment to 1 protein entry:     CPXM1_HUMAN:
    DKFZp666J235    CPXM2    AEBP1    CPE    CPN1    CPZ
    CPM

    CPXM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/341 SNPs in CPXM1 are shown (see all 341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800417641,2
    F--2774277(+) TTCTAT/CTGCAT 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1145212101,2
    C,F--2774300(+) CAGTCC/TTGTTG 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1884356141,2
    --2774357(+) GGCACA/CTGGCC 2 -- ds50010--------
    rs1819117511,2
    --2774457(+) ATTCCC/TTGCAC 2 -- ds50010--------
    rs1862895611,2
    --2774517(+) TACCTA/GTAGCA 2 -- ds50010--------
    rs735840331,2
    C,F--2774562(+) GCCCTT/CGGTTC 2 -- ds50012Minor allele frequency- C:0.03WA 120
    rs2155371,2
    C,F,A--2774605(+) CAATGT/CGTCCA 2 -- ds50014Minor allele frequency- C:0.03MN NA 308
    rs2155381,2
    C,F,A--2774629(+) GAGAGT/AGTGCA 2 -- ds50019Minor allele frequency- A:0.32EA MN NA WA CSA 2052
    rs1128849561,2
    C,F--2774639(+) AAGTGT/CGCAGA 2 -- ds50014Minor allele frequency- C:0.13WA CSA 124
    rs758056251,2
    C,F--2774666(+) GGGCCG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for CPXM1 (2774715 - 2781292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPXM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833895CNV Loss17160897
    nsv510780CNV Loss20534489
    nsv522009CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPXM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CPXM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609555    OMIM disorders: --

    2 diseases for CPXM1:    About MalaCards
    lymphedema    

    1 disease from the University of Copenhagen DISEASES database for CPXM1:
    Lymphedema

    CPXM1 for disorders           About GeneDecksing


    Export disorders for CPXM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPXM1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CPXM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    8. An unappreciated role for RNA surveillance. (PubMed id 14759258)1 Hillman R.T.... Brenner S.E. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2. (PubMed id 10073577)1 Lei Y....Fricker L.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56265 HGNC: 15771 AceView: CPXM Ensembl:ENSG00000088882 euGenes: HUgn56265
    ECgene: CPXM1 H-InvDB: CPXM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPXM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPXM1 gene:
    Search GeneIP for patents involving CPXM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CPXM1 (Carboxypeptidase X1/CPXM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CPXM1  
     OriGene qPCR primer pairs and template standards for CPXM1   OriGene Protein Over-expression Lysate for CPXM1  
     OriGene MassSpec something-or-other for CPXM1   OriGene clones in human, mouse for CPXM1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CPXM1   OriGene Purified Protein for CPXM1  
     OriGene ORF clones in mouse, rat for CPXM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CPXM1   OriGene Custom Protein Services for CPXM1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPXM1
     QIAGEN SeqTarget long-range PCR primers for resequencing CPXM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPXM1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPXM1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPXM1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPXM1
     GenScript Custom Purified and Recombinant Proteins Services for CPXM1 GenScript cDNA clones with any tag delivered in your preferred vector for CPXM1
     GenScript Custom Assay Services for CPXM1 GenScript Custom Superior Antibodies Services for CPXM1
     GenScript Custom overexpressing Cell Line Services for CPXM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CPXM1 promoter
     Search Chromatin IP Primers for CPXM1
     RT2 qPCR Primer Assay in human, mouse, rat CPXM1
     Search GNC Networks for CPXM1
     SABiosciences Custom PCR Arrays for CPXM1
     Search Tocris compounds for CPXM1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CPXM1 antibodies
     CPXM1 proteins
     CPXM1 lysates
     Antibodies for CPXM1
     See all of Abcam's Antibodies, Kits and Proteins for CPXM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CPXM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXM1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CPXM1
     SwitchGear Promoter luciferase reporter plasmids for CPXM1
     ThermoFisher Antibodies for CPXM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPXM1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CPXM1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPXM1
    Customized:
     lentivirus for stable overexpression of CPXM1
     lentivirus expression plasmids for stable overexpression of CPXM1
     adenovirus for overexpression of CPXM1
     LSBio Antibodies in human, mouse, rat for CPXM1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CPXM1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4