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Aliases for CPXCR1 Gene

Aliases for CPXCR1 Gene

  • CPX Chromosome Region, Candidate 1 2 3 5
  • Cancer/Testis Antigen 77 2 3 4
  • CT77 3 4
  • CPX Chromosomal Region Candidate Gene 1 Protein 3

External Ids for CPXCR1 Gene

Previous GeneCards Identifiers for CPXCR1 Gene

  • GC0XP083274
  • GC0XP084971
  • GC0XP086037
  • GC0XP086774
  • GC0XP087808
  • GC0XP088002
  • GC0XP081584

Summaries for CPXCR1 Gene

Entrez Gene Summary for CPXCR1 Gene

  • This gene is one of several genes identified in a region of the X chromosome associated with an X-linked cleft palate (CPX) disorder. The encoded protein contains a motif similar to a motif found in zinc-finger proteins. Mutation analysis of this gene has not revealed any mutation which causes the CPX disorder. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for CPXCR1 Gene

CPXCR1 (CPX Chromosome Region, Candidate 1) is a Protein Coding gene. Diseases associated with CPXCR1 include Ankyloglossia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXCR1 Gene

Genomics for CPXCR1 Gene

Regulatory Elements for CPXCR1 Gene

Enhancers for CPXCR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF088612 0.7 ENCODE 0.1 -133.8 -133843 0.9 CTCF ZNF654 FOXA3 ZNF384 RAD21 YY1 SMC3 EHMT2 PRDM1 CPXCR1 GC0XM088362
GH0XF088604 0.9 ENCODE 0.1 -142.2 -142231 0.2 ELF3 TBP MLX ARID4B ZSCAN9 RAD21 RARA CREM MIXL1 THAP11 CPXCR1 GC0XM088362
GH0XF088464 0.2 ENCODE 0.1 -282.5 -282544 0.9 GC0XM088362 CPXCR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CPXCR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPXCR1 Gene

Chromosome:
X
Start:
88,747,225 bp from pter
End:
88,754,785 bp from pter
Size:
7,561 bases
Orientation:
Plus strand

Genomic View for CPXCR1 Gene

Genes around CPXCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPXCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXCR1 Gene

Proteins for CPXCR1 Gene

  • Protein details for CPXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N123-CPXCR_HUMAN
    Recommended name:
    CPX chromosomal region candidate gene 1 protein
    Protein Accession:
    Q8N123
    Secondary Accessions:
    • B2R9F9
    • D3DTE7
    • Q96RS3

    Protein attributes for CPXCR1 Gene

    Size:
    301 amino acids
    Molecular mass:
    34727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPXCR1 Gene

Post-translational modifications for CPXCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPXCR1 Gene

Antibody Products

  • Abcam antibodies for CPXCR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CPXCR1

No data available for DME Specific Peptides for CPXCR1 Gene

Domains & Families for CPXCR1 Gene

Protein Domains for CPXCR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPXCR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CPXCR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CPXCR1 Gene

Function for CPXCR1 Gene

Gene Ontology (GO) - Molecular Function for CPXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPXCR1: view
genes like me logo Genes that share phenotypes with CPXCR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPXCR1 Gene

Localization for CPXCR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPXCR1 Gene COMPARTMENTS Subcellular localization image for CPXCR1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPXCR1 Gene

Pathways & Interactions for CPXCR1 Gene

SuperPathways for CPXCR1 Gene

No Data Available

Interacting Proteins for CPXCR1 Gene

Selected Interacting proteins: Q8N123-CPXCR_HUMAN for CPXCR1 Gene via IID

Gene Ontology (GO) - Biological Process for CPXCR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPXCR1 Gene

Transcripts for CPXCR1 Gene

mRNA/cDNA for CPXCR1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPXCR1 Gene

CPX chromosome region, candidate 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPXCR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for CPXCR1 Gene

GeneLoc Exon Structure for
CPXCR1
ECgene alternative splicing isoforms for
CPXCR1

Expression for CPXCR1 Gene

mRNA expression in normal human tissues for CPXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CPXCR1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for CPXCR1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPXCR1 Gene



Protein tissue co-expression partners for CPXCR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPXCR1 Gene:

CPXCR1

SOURCE GeneReport for Unigene cluster for CPXCR1 Gene:

Hs.458292

mRNA Expression by UniProt/SwissProt for CPXCR1 Gene:

Q8N123-CPXCR_HUMAN
Tissue specificity: Expressed in a variety of fetal tissues.
genes like me logo Genes that share expression patterns with CPXCR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPXCR1 Gene

Orthologs for CPXCR1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CPXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPXCR1 34 35
  • 99.22 (n)
mouse
(Mus musculus)
Mammalia Cpxcr1 34 16 35
  • 63.82 (n)
Species where no ortholog for CPXCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CPXCR1 Gene

ENSEMBL:
Gene Tree for CPXCR1 (if available)
TreeFam:
Gene Tree for CPXCR1 (if available)

Paralogs for CPXCR1 Gene

No data available for Paralogs for CPXCR1 Gene

Variants for CPXCR1 Gene

Sequence variations from dbSNP and Humsavar for CPXCR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10593202 -- 88,748,323(+) ATATT(-/TAATG)TATAT intron-variant
rs111280995 -- 88,753,654(+) GATCA(A/G)CGAGA reference, synonymous-codon
rs111361844 -- 88,755,045(+) CTTCC(C/T)CTCCA downstream-variant-500B
rs111373839 -- 88,745,909(+) CCAGC(A/G)TATTG upstream-variant-2KB
rs111741645 -- 88,745,882(+) AAAGC(C/T)TCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPXCR1 Gene

Variant ID Type Subtype PubMed ID
nsv515219 CNV loss 21397061

Variation tolerance for CPXCR1 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.52; 77.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPXCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPXCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXCR1 Gene

Disorders for CPXCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPXCR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ankyloglossia
  • tongue-tie
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CPXCR1

Genetic Association Database (GAD)
CPXCR1
Human Genome Epidemiology (HuGE) Navigator
CPXCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPXCR1
genes like me logo Genes that share disorders with CPXCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPXCR1 Gene

Publications for CPXCR1 Gene

  1. Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region. (PMID: 11499681) Braybrook C. … Stanier P. (Hum. Genet. 2001) 2 3 4 64
  2. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons P.A. … Smith K.G. (N. Engl. J. Med. 2012) 3 64
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3 64
  4. [Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer]. (PMID: 19035188) Wang J. … Xiao Y. (Zhonghua Yu Fang Yi Xue Za Zhi 2008) 46 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64

Products for CPXCR1 Gene

Sources for CPXCR1 Gene

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