CPXCR1 Gene
protein-coding GIFtS: 44
GCID: GC0XP088002
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CPX chromosome region, candidate 1
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Aliases
for CPXCR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CPX Chromosome Region, Candidate 11 2 | | CT771 2 3 | | Cancer/Testis Antigen 772 3 | | CPX Chromosomal Region Candidate Gene 1 Protein2 |
Export aliases for CPXCR1 gene to outside databasesPrevious GC identifers: GC0XP083274 GC0XP084971 GC0XP086037 GC0XP086774 GC0XP087808 GC0XP081584 |
Summaries
for CPXCR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CPXCR1:
This gene is one of several genes identified in a region of the X chromosome associated with an X-linked cleft palate(CPX) disorder. The encoded protein contains a motif similar to a motif found in zinc-finger proteins. Mutationanalysis of this gene has not revealed any mutation which causes the CPX disorder. Multiple alternatively splicedvariants, encoding the same protein, have been identified. (provided by RefSeq, Sep 2011)
|
Genomic Views
for CPXCR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPXCR1 gene promoter:
FOXJ2 (long isoform) Sox9 FOXJ2 NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPXCR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPXCR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.3 Ensembl cytogenetic band: Xq21.31 HGNC cytogenetic band: Xq21.3CPXCR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP088002: view genomic region
(about GC identifiers)
Start:
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88,002,226 bp from pter |
End:
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88,009,786 bp from pter |
Size:
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7,561 bases |
Orientation:
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plus strand |
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Proteins
for CPXCR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPXCR_HUMAN, Q8N123 (See
protein sequence)Recommended Name: CPX chromosomal region candidate gene 1 protein Size: 301 amino acids; 34727 Da
Secondary accessions: B2R9F9 D3DTE7 Q96RS3Explore the universe of human proteins at neXtProt for CPXCR1: NX_Q8N123
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N123
CPXCR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171700.1 NP_149037.4
ENSEMBL proteins: ENSP00000276127 ENSP00000362203
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
CPXCR1 for ontologies About GeneDecksing
CPXCR1 Antibody Products:
Assay Products for CPXCR1: |
Protein
Domains /
Families
for CPXCR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPXCR1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N123ProtoNet protein and cluster: Q8N123 |
Function
for CPXCR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPXCR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPXCR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXCR1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
CPXCR1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CPXCR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPXCR1
1 Interacting protein for CPXCR1 (Q8N1232) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CPXCR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPXCR1
Search CenterWatch for drugs/clinical trials and news about CPXCR1 / CPXCR
|
Transcripts
for CPXCR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPXCR1 gene (2 alternative transcripts): NM_001184771.1 NM_033048.5 Unigene Cluster for CPXCR1: CPX chromosome region, candidate 1 Hs.458292 [show with all ESTs]Unigene Representative Sequence: NM_0330482 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276127(uc004efd.4 uc004efc.4) ENST00000373111
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPXCR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPXCR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CPXCR1 (NM_033048) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPXCR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPXCR1 |
Additional cDNA sequence: AF284767.1 AK098646.1 AK313768.1 BC027614.2 2 DOTS entries: DT.100687295 DT.97790621 12 AceView cDNA sequences: AF284767 AK098646 BQ432767 BU570042 BU171477 BG773380 BU568617 BQ429621 NM_033048 BX099988 BC027614 AA724780
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CPXCR1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for CPXCR1
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Expression
for CPXCR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPXCR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACATAAATT
About this image
See CPXCR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPXCR1
SOURCE GeneReport for Unigene cluster: Hs.458292
UniProtKB/Swiss-Prot: CPXCR_HUMAN, Q8N123Tissue specificity: Expressed in a variety of fetal tissues
SABiosciences Custom PCR Arrays for CPXCR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPXCR1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXCR1 |
Orthologs
for CPXCR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CPXCR1 gene from 1/2 species (see all 2) About this table
ENSEMBL Gene Tree for CPXCR1 (if available)
TreeFam Gene Tree for CPXCR1 (if available) |
Paralogs
for CPXCR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CPXCR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPXCR1 (88002226 - 88009786 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CPXCR1: --
Locus Specific Mutation Databases (LSDB): CPXCR1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPXCR1 |
|
Disorders
/ Diseases
for CPXCR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPXCR1 for disorders About GeneDecksing
4  diseases for CPXCR1: About MalaCardscleft palate cleft palate with ankyloglossia uterine fibroid leiomyoma
Human Genome Epidemiology (HuGE) Navigator: CPXCR1 (1 document)
Export disorders for CPXCR1 gene to outside databases
|
Publications
for CPXCR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPXCR1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CPXCR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region. (PubMed id 11499681)1, 2, 3 Braybrook C.... Stanier P. (2001)
- Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CPXCR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CPXCR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPXCR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CPXCR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CPXCR1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CPXCR1 gene:
Search GeneIP for patents involving CPXCR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CPXCR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | CPXCR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPXCR1 |
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