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Aliases for CPVL Gene

Aliases for CPVL Gene

  • Carboxypeptidase, Vitellogenic Like 2 3 5
  • Vitellogenic Carboxypeptidase-Like Protein 2 3 4
  • Carboxypeptidase, Vitellogenic-Like 2 4
  • CP-Mac Carboxypeptidase 2 3
  • Carboxypeptidase WUG 2 3
  • VCP-Like Protein 3 4
  • HVLP 3 4
  • Probable Serine Carboxypeptidase CPVL 3
  • EC 3.4.16.- 4
  • EC 3.4.16 61
  • VLP 4

External Ids for CPVL Gene

Previous GeneCards Identifiers for CPVL Gene

  • GC07M028677
  • GC07M028743
  • GC07M028777
  • GC07M028808
  • GC07M029001
  • GC07M028917

Summaries for CPVL Gene

Entrez Gene Summary for CPVL Gene

  • The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two alternatively spliced transcripts which encode the same protein have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPVL Gene

CPVL (Carboxypeptidase, Vitellogenic Like) is a Protein Coding gene. Diseases associated with CPVL include Exudative Vitreoretinopathy 1. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CTSA.

UniProtKB/Swiss-Prot for CPVL Gene

  • May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Gene Wiki entry for CPVL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPVL Gene

Genomics for CPVL Gene

Regulatory Elements for CPVL Gene

Enhancers for CPVL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F029113 1.1 Ensembl ENCODE 21.2 +80.5 80528 3.8 ELF3 PKNOX1 FEZF1 DNMT3B RAD21 RARA ZNF207 FOS ZNF654 ETV4 CPVL LOC107986703 LOC102724484 CHN2
GH07F029139 1.2 Ensembl ENCODE 17.7 +53.6 53562 5.8 MLX ARID4B DMAP1 ZNF48 SLC30A9 ZNF263 SP5 MXD4 MIER2 PPARG CPVL CHN2 LOC101928168 GC07M029191
GH07F029336 1.5 FANTOM5 Ensembl ENCODE 12 -142.2 -142154 2.4 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SP5 NFYC MXD4 MIER2 CHN2 CPVL LOC102724484 GC07P029212 GC07M029201
GH07F029288 1.4 FANTOM5 Ensembl ENCODE 12 -94.1 -94052 1.8 ELF3 PKNOX1 RAD21 RARA SCRT2 CREM MIXL1 TBX21 PPARG SMARCA4 CHN2 CPVL LOC102724484 GC07P029212 GC07M029201
GH07F029228 1.2 FANTOM5 ENCODE 12.3 -33.6 -33603 1.5 ELF3 ARID4B RAD21 RARA YY1 CREM MIXL1 THAP11 SP5 CEBPB CHN2 LOC102724484 CPVL LOC107986703 GC07P029212 GC07M029201
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPVL on UCSC Golden Path with GeneCards custom track

Promoters for CPVL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001049391 251 2401 ELF3 TBP KLF17 ARID4B ZNF48 RAD21 ZNF2 YY1 GLIS2 ZNF366

Genomic Location for CPVL Gene

28,995,231 bp from pter
29,195,451 bp from pter
200,221 bases
Minus strand

Genomic View for CPVL Gene

Genes around CPVL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPVL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPVL Gene

Proteins for CPVL Gene

  • Protein details for CPVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable serine carboxypeptidase CPVL
    Protein Accession:
    Secondary Accessions:
    • A4D1A4
    • Q6UX20
    • Q8NBL7
    • Q96AR7
    • Q9HB41

    Protein attributes for CPVL Gene

    476 amino acids
    Molecular mass:
    54164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPVL Gene

Selected DME Specific Peptides for CPVL Gene


Post-translational modifications for CPVL Gene

  • Ubiquitination at Lys 280, Lys 331, Lys 423, and Lys 469
  • Glycosylation at Asn 81, Asn 132, Asn 307, and Asn 346
  • Modification sites at PhosphoSitePlus

Domains & Families for CPVL Gene

Gene Families for CPVL Gene

Suggested Antigen Peptide Sequences for CPVL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S10 family.
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with CPVL: view

Function for CPVL Gene

Molecular function for CPVL Gene

UniProtKB/Swiss-Prot Function:
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Enzyme Numbers (IUBMB) for CPVL Gene

Gene Ontology (GO) - Molecular Function for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004185 serine-type carboxypeptidase activity IEA,IBA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPVL: view
genes like me logo Genes that share phenotypes with CPVL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPVL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPVL Gene

Localization for CPVL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPVL gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CPVL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPVL Gene

Pathways & Interactions for CPVL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CPVL: view

No data available for Pathways by source and SIGNOR curated interactions for CPVL Gene

Transcripts for CPVL Gene

Unigene Clusters for CPVL Gene

Carboxypeptidase, vitellogenic-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPVL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -

Relevant External Links for CPVL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPVL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPVL Gene

This gene is overexpressed in Whole Blood (x8.0), Spleen (x6.0), and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for CPVL Gene

This gene is overexpressed in Fetal gut (12.9), Spleen (10.4), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPVL Gene

Protein tissue co-expression partners for CPVL Gene

NURSA nuclear receptor signaling pathways regulating expression of CPVL Gene:


SOURCE GeneReport for Unigene cluster for CPVL Gene:


mRNA Expression by UniProt/SwissProt for CPVL Gene:

Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
genes like me logo Genes that share expression patterns with CPVL: view

Orthologs for CPVL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPVL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPVL 34 35
  • 99.23 (n)
(Bos Taurus)
Mammalia CPVL 34 35
  • 83.96 (n)
(Canis familiaris)
Mammalia CPVL 34 35
  • 83.9 (n)
(Rattus norvegicus)
Mammalia Cpvl 34
  • 79.32 (n)
(Mus musculus)
Mammalia Cpvl 34 16 35
  • 79.18 (n)
(Monodelphis domestica)
Mammalia CPVL 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CPVL 35
  • 67 (a)
(Anolis carolinensis)
Reptilia CPVL 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpvl 34
  • 65.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22832 34
(Danio rerio)
Actinopterygii cpvl 34 35
  • 62.79 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2569 34
fruit fly
(Drosophila melanogaster)
Insecta CG4572 36 34 35
  • 53.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007505 34
  • 53.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 21 (a)
PRC1 35
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons scpl50 34
  • 48 (n)
(Oryza sativa)
Liliopsida Os01g0215100 34
  • 45.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
-- 35
  • 28 (a)
-- 35
  • 26 (a)
CSA.11111 35
  • 16 (a)
Species where no ortholog for CPVL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPVL Gene

Gene Tree for CPVL (if available)
Gene Tree for CPVL (if available)

Paralogs for CPVL Gene

Paralogs for CPVL Gene

genes like me logo Genes that share paralogs with CPVL: view

Variants for CPVL Gene

Sequence variations from dbSNP and Humsavar for CPVL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1012090 -- 28,995,224(+) ATTGA(C/T)TCATC intron-variant, downstream-variant-500B
rs10228797 -- 28,995,938(+) AATAC(A/G)TGGAA intron-variant
rs10235164 -- 29,015,315(+) gatct(A/G)tgtcc intron-variant
rs10237814 -- 29,021,255(+) acagc(C/T)tatga intron-variant
rs10239350 -- 29,097,105(+) AATAA(A/C)AACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPVL Gene

Variant ID Type Subtype PubMed ID
nsv525084 CNV loss 19592680
nsv1137205 CNV deletion 24896259
esv3612688 CNV loss 21293372
esv3612687 CNV loss 21293372
esv3612685 CNV loss 21293372
esv3612679 CNV loss 21293372
esv3450095 CNV insertion 20981092
esv3424078 CNV insertion 20981092
esv3363043 CNV insertion 20981092
esv3305886 CNV mobile element insertion 20981092
esv2734181 CNV deletion 23290073
esv2734180 CNV deletion 23290073
esv2734179 CNV deletion 23290073
esv2173744 CNV deletion 18987734

Variation tolerance for CPVL Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPVL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPVL Gene

Disorders for CPVL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPVL Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search CPVL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPVL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPVL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPVL Gene

Publications for CPVL Gene

  1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PMID: 11401439) Mahoney J.A. … McKnight A.J. (Genomics 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PMID: 20460425) Maeda S. … Nakamura Y. (Diabetes 2010) 3 46 64
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs J.B. … Dupuis J. (BMC Med. Genet. 2007) 3 46 64

Products for CPVL Gene

Sources for CPVL Gene

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