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Aliases for CPVL Gene

Aliases for CPVL Gene

  • Carboxypeptidase, Vitellogenic Like 2 3
  • Carboxypeptidase, Vitellogenic-Like 2 3 4 5
  • Vitellogenic Carboxypeptidase-Like Protein 2 3 4
  • CP-Mac Carboxypeptidase 2 3
  • Carboxypeptidase WUG 2 3
  • VCP-Like Protein 3 4
  • HVLP 3 4
  • EC 3.4.16.- 4
  • EC 3.4.16 63
  • VLP 4

External Ids for CPVL Gene

Previous GeneCards Identifiers for CPVL Gene

  • GC07M028677
  • GC07M028743
  • GC07M028777
  • GC07M028808
  • GC07M029001
  • GC07M028917

Summaries for CPVL Gene

Entrez Gene Summary for CPVL Gene

  • The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two alternatively spliced transcripts which encode the same protein have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPVL Gene

CPVL (Carboxypeptidase, Vitellogenic Like) is a Protein Coding gene. Diseases associated with CPVL include Exudative Vitreoretinopathy 1. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is SCPEP1.

UniProtKB/Swiss-Prot for CPVL Gene

  • May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Gene Wiki entry for CPVL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPVL Gene

Genomics for CPVL Gene

Regulatory Elements for CPVL Gene

Enhancers for CPVL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPVL on UCSC Golden Path with GeneCards custom track

Promoters for CPVL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPVL on UCSC Golden Path with GeneCards custom track

Genomic Location for CPVL Gene

28,995,231 bp from pter
29,195,451 bp from pter
200,221 bases
Minus strand

Genomic View for CPVL Gene

Genes around CPVL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPVL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPVL Gene

Proteins for CPVL Gene

  • Protein details for CPVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable serine carboxypeptidase CPVL
    Protein Accession:
    Secondary Accessions:
    • A4D1A4
    • Q6UX20
    • Q8NBL7
    • Q96AR7
    • Q9HB41

    Protein attributes for CPVL Gene

    476 amino acids
    Molecular mass:
    54164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPVL Gene

Proteomics data for CPVL Gene at MOPED

Selected DME Specific Peptides for CPVL Gene

Post-translational modifications for CPVL Gene

  • Ubiquitination at Lys 280, Lys 331, Lys 423, and Lys 469
  • Glycosylation at Asn 81, Asn 132, Asn 307, and Asn 346
  • Modification sites at PhosphoSitePlus

Domains & Families for CPVL Gene

Gene Families for CPVL Gene

Suggested Antigen Peptide Sequences for CPVL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S10 family.
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with CPVL: view

Function for CPVL Gene

Molecular function for CPVL Gene

UniProtKB/Swiss-Prot Function:
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Enzyme Numbers (IUBMB) for CPVL Gene

genes like me logo Genes that share phenotypes with CPVL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPVL

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPVL Gene

Localization for CPVL Gene

Subcellular locations from

Jensen Localization Image for CPVL Gene COMPARTMENTS Subcellular localization image for CPVL gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPVL Gene

Pathways & Interactions for CPVL Gene

SuperPathways for CPVL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CPVL: view

No data available for Pathways by source and SIGNOR curated interactions for CPVL Gene

Drugs & Compounds for CPVL Gene

No Compound Related Data Available

Transcripts for CPVL Gene

Unigene Clusters for CPVL Gene

Carboxypeptidase, vitellogenic-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPVL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -

Relevant External Links for CPVL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPVL Gene

mRNA expression in normal human tissues for CPVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPVL Gene

This gene is overexpressed in Whole Blood (x8.0), Spleen (x6.0), and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for CPVL Gene

This gene is overexpressed in Fetal gut (12.9), Spleen (10.4), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPVL Gene

SOURCE GeneReport for Unigene cluster for CPVL Gene Hs.233389

mRNA Expression by UniProt/SwissProt for CPVL Gene

Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
genes like me logo Genes that share expression patterns with CPVL: view

Protein tissue co-expression partners for CPVL Gene

Primer Products

Orthologs for CPVL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPVL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPVL 35
  • 83.96 (n)
  • 79.25 (a)
  • 77 (a)
(Canis familiaris)
Mammalia CPVL 35
  • 83.9 (n)
  • 77.22 (a)
  • 72 (a)
(Mus musculus)
Mammalia Cpvl 35
  • 79.18 (n)
  • 76.37 (a)
Cpvl 16
Cpvl 36
  • 76 (a)
(Pan troglodytes)
Mammalia CPVL 35
  • 99.23 (n)
  • 98.32 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Cpvl 35
  • 79.32 (n)
  • 74.89 (a)
(Monodelphis domestica)
Mammalia CPVL 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CPVL 36
  • 67 (a)
(Anolis carolinensis)
Reptilia CPVL 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpvl 35
  • 65.17 (n)
  • 61.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22832 35
(Danio rerio)
Actinopterygii cpvl 35
  • 62.79 (n)
  • 62.28 (a)
cpvl 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2569 35
fruit fly
(Drosophila melanogaster)
Insecta CG4572 37
  • 44 (a)
CG4572 35
  • 53.13 (n)
  • 46.01 (a)
CG4572 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007505 35
  • 53.01 (n)
  • 46.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
PRC1 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons scpl50 35
  • 48 (n)
  • 37.08 (a)
(Oryza sativa)
Liliopsida Os01g0215100 35
  • 45.97 (n)
  • 35.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 28 (a)
-- 36
  • 26 (a)
CSA.11111 36
  • 16 (a)
Species with no ortholog for CPVL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPVL Gene

Gene Tree for CPVL (if available)
Gene Tree for CPVL (if available)

Paralogs for CPVL Gene

Paralogs for CPVL Gene

genes like me logo Genes that share paralogs with CPVL: view

Variants for CPVL Gene

Sequence variations from dbSNP and Humsavar for CPVL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7313 - 29,030,593(-) GCAAG(C/T)GGGTG reference, missense
rs36074676 - 29,121,030(+) CCAGC(A/G)AAACA reference, missense
rs34219043 - 29,120,988(+) GGGAG(C/G/T)GAAAC reference, missense
rs1052200 - 29,030,704(-) AGAGC(A/G)CTCCT reference, missense
rs765994 -- 29,032,760(+) ATCTC(C/T)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPVL Gene

Variant ID Type Subtype PubMed ID
esv2734179 CNV Deletion 23290073
esv2173744 CNV Deletion 18987734
esv2734180 CNV Deletion 23290073
esv2734181 CNV Deletion 23290073
nsv525084 CNV Loss 19592680
esv267722 CNV Insertion 20981092
esv270163 CNV Insertion 20981092

Variation tolerance for CPVL Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPVL Gene

Disorders for CPVL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPVL Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search CPVL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPVL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPVL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPVL Gene

Publications for CPVL Gene

  1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PMID: 11401439) Mahoney J.A. … McKnight A.J. (Genomics 2001) 2 3 4 23 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CPVL Gene

Sources for CPVL Gene