Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPVL Gene

Aliases for CPVL Gene

  • Carboxypeptidase, Vitellogenic-Like 2 3 4
  • Vitellogenic Carboxypeptidase-Like Protein 2 3 4
  • HVLP 3 4 6
  • CP-Mac Carboxypeptidase 2 3
  • Carboxypeptidase WUG 2 3
  • VCP-Like Protein 3 4
  • Probable Serine Carboxypeptidase CPVL 3
  • EC 3.4.16.- 4
  • EC 3.4.16 63
  • VLP 4

External Ids for CPVL Gene

Previous GeneCards Identifiers for CPVL Gene

  • GC07M028677
  • GC07M028743
  • GC07M028777
  • GC07M028808
  • GC07M029001
  • GC07M028917

Summaries for CPVL Gene

Entrez Gene Summary for CPVL Gene

  • The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two alternatively spliced transcripts which encode the same protein have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPVL Gene

CPVL (Carboxypeptidase, Vitellogenic-Like) is a Protein Coding gene. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CTSA.

UniProtKB/Swiss-Prot for CPVL Gene

  • May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation

Gene Wiki entry for CPVL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPVL Gene

Genomics for CPVL Gene

Regulatory Elements for CPVL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPVL Gene

Start:
28,995,231 bp from pter
End:
29,195,451 bp from pter
Size:
200,221 bases
Orientation:
Minus strand

Genomic View for CPVL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPVL Gene

Proteins for CPVL Gene

  • Protein details for CPVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3G5-CPVL_HUMAN
    Recommended name:
    Probable serine carboxypeptidase CPVL
    Protein Accession:
    Q9H3G5
    Secondary Accessions:
    • A4D1A4
    • Q6UX20
    • Q8NBL7
    • Q96AR7
    • Q9HB41

    Protein attributes for CPVL Gene

    Size:
    476 amino acids
    Molecular mass:
    54164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPVL Gene

Proteomics data for CPVL Gene at MOPED

Selected DME Specific Peptides for CPVL Gene

Post-translational modifications for CPVL Gene

  • Ubiquitination at Lys280, Lys331, Lys423, and Lys469
  • Glycosylation at Asn81, Asn132, Asn307, and Asn346
  • Modification sites at PhosphoSitePlus

Domains for CPVL Gene

Suggested Antigen Peptide Sequences for CPVL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3G5

UniProtKB/Swiss-Prot:

CPVL_HUMAN :
  • Q9H3G5
Family:
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with CPVL: view

Function for CPVL Gene

Molecular function for CPVL Gene

UniProtKB/Swiss-Prot Function: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation

Enzyme Numbers (IUBMB) for CPVL Gene

Gene Ontology (GO) - Molecular Function for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004185 serine-type carboxypeptidase activity IEA --
genes like me logo Genes that share ontologies with CPVL: view

Phenotypes for CPVL Gene

MGI mutant phenotypes for CPVL:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CPVL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPVL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPVL Gene

Localization for CPVL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPVL Gene COMPARTMENTS Subcellular localization image for CPVL gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CPVL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPVL Gene

Pathways for CPVL Gene

SuperPathways for CPVL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPVL: view

No data available for Pathways by source for CPVL Gene

Transcripts for CPVL Gene

Unigene Clusters for CPVL Gene

Carboxypeptidase, vitellogenic-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPVL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPVL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for CPVL Gene

GeneLoc Exon Structure for
CPVL
ECgene alternative splicing isoforms for
CPVL

Expression for CPVL Gene

mRNA expression in normal human tissues for CPVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPVL Gene

This gene is overexpressed in Whole Blood (8.0), Spleen (6.0), and Heart - Left Ventricle (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPVL Gene

SOURCE GeneReport for Unigene cluster for CPVL Gene Hs.233389

mRNA Expression by UniProt/SwissProt for CPVL Gene

Q9H3G5-CPVL_HUMAN
Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta
genes like me logo Genes that share expressions with CPVL: view

In Situ Assay Products

Orthologs for CPVL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPVL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPVL 35
  • 99.23 (n)
  • 98.32 (a)
CPVL 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPVL 35
  • 83.96 (n)
  • 79.25 (a)
CPVL 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPVL 35
  • 83.9 (n)
  • 77.22 (a)
CPVL 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpvl 35
  • 79.18 (n)
  • 76.37 (a)
Cpvl 16
Cpvl 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPVL 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPVL 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpvl 35
  • 79.32 (n)
  • 74.89 (a)
lizard
(Anolis carolinensis)
Reptilia CPVL 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22832 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpvl 35
  • 65.17 (n)
  • 61.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2569 35
zebrafish
(Danio rerio)
Actinopterygii cpvl 35
  • 62.79 (n)
  • 62.28 (a)
cpvl 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007505 35
  • 53.01 (n)
  • 46.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4572 35
  • 53.13 (n)
  • 46.01 (a)
CG4572 36
  • 39 (a)
OneToOne
CG4572 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
ManyToMany
PRC1 36
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons scpl50 35
  • 48 (n)
  • 37.08 (a)
rice
(Oryza sativa)
Liliopsida Os01g0215100 35
  • 45.97 (n)
  • 35.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
CSA.11111 36
  • 16 (a)
ManyToMany
Species with no ortholog for CPVL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPVL Gene

ENSEMBL:
Gene Tree for CPVL (if available)
TreeFam:
Gene Tree for CPVL (if available)

Paralogs for CPVL Gene

Paralogs for CPVL Gene

Selected SIMAP similar genes for CPVL Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with CPVL: view

Variants for CPVL Gene

Sequence variations from dbSNP and Humsavar for CPVL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7313 - 29,030,593(-) GCAAG(C/T)GGGTG reference, missense
rs24650 -- 29,015,962(+) TGTGG(C/T)AGACC intron-variant
rs24651 -- 29,016,142(+) GGTCA(C/G)GAGTT intron-variant
rs122504 -- 29,061,110(+) GATTC(A/T)GAGTT intron-variant
rs160836 -- 29,075,516(-) TTAAG(A/G)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPVL Gene

Variant ID Type Subtype PubMed ID
esv2734179 CNV Deletion 23290073
esv2173744 CNV Deletion 18987734
esv2734180 CNV Deletion 23290073
esv2734181 CNV Deletion 23290073
nsv525084 CNV Loss 19592680
esv267722 CNV Insertion 20981092
esv270163 CNV Insertion 20981092

Relevant External Links for CPVL Gene

HapMap Linkage Disequilibrium report
CPVL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPVL Gene

Disorders for CPVL Gene

Relevant External Links for CPVL

Genetic Association Database (GAD)
CPVL
Human Genome Epidemiology (HuGE) Navigator
CPVL
genes like me logo Genes that share disorders with CPVL: view

No data available for UniProtKB/Swiss-Prot for CPVL Gene

Publications for CPVL Gene

  1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PMID: 11401439) Mahoney J.A. … McKnight A.J. (Genomics 2001) 2 3 4 23
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for CPVL Gene

Sources for CPVL Gene

Back to Top

Content