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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPVL Gene

protein-coding   GIFtS: 55
GCID: GC07M029001

carboxypeptidase, vitellogenic-like
 Explore 9 diseases affiliated with
CPVL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPVL    

Aliases
for CPVL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase, Vitellogenic-Like1 2 3     Probable Serine Carboxypeptidase CPVL2
Vitellogenic Carboxypeptidase-Like Protein2 3     EC 3.4.16.-3
VCP-Like Protein2 3     VLP3
HVLP2 5     HVLP2 5
Carboxypeptidase WUG2     EC 3.4.168
CP-Mac Carboxypeptidase2     

External Ids:    HGNC: 143991   Entrez Gene: 545042   Ensembl: ENSG000001060667   OMIM: 6097805   UniProtKB: Q9H3G53   

Export aliases for CPVL gene to outside databases

Previous GC identifers: GC07M028677 GC07M028743 GC07M028777 GC07M028808 GC07M028917


Summaries
for CPVL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPVL:
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine
carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the
carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At
least two alternatively spliced transcripts which encode the same protein have been observed. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
Function: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory
protease cascade, and trimming of peptides for antigen presentation

Gene Wiki entry for CPVL


Genomic Views
for CPVL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPVL gene promoter:
         HOXA3   AML1a   CUTL1   POU3F2   C/EBPalpha   Evi-1   S8   IRF-2   POU2F1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CPVL promoter sequence
   Search SABiosciences Chromatin IP Primers for CPVL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPVL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15.1

CPVL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPVL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M029001:  view genomic region     (about GC identifiers)

Start:
 29,034,847 bp from pter      End:
 29,235,067 bp from pter
Size:
 200,221 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 29,085,477-29,236,357     

Proteins
for CPVL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5 (See protein sequence)
Recommended Name: Probable serine carboxypeptidase CPVL precursor  
Size: 476 amino acids; 54164 Da
Secondary accessions: A4D1A4 Q6UX20 Q8NBL7 Q96AR7 Q9HB41

Explore the universe of human proteins at neXtProt for CPVL: NX_Q9H3G5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3G5

    • 4 DME Specific Peptides for CPVL (Q9H3G5)
     TGESYAG  PVGTGFS  NSNLFFW  NLFFWFFPA 

    CPVL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_061902.2  NP_112601.3  

    ENSEMBL proteins: 
     ENSP00000265394   ENSP00000379572   ENSP00000397327   ENSP00000403580   ENSP00000387164  
     ENSP00000409036   ENSP00000417015   ENSP00000395690   ENSP00000413287   ENSP00000412857  
     ENSP00000416555  

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    Novus Biologicals CPVL Protein
    Novus Biologicals CPVL Lysates
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    Uscn Proteins for CPVL


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    Uscn Antibodies for CPVL
    ThermoFisher Antibodies for CPVL

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    Uscn ELISAs and CLIAs for CPVL

    Protein Domains /
    Families
    for CPVL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPVL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018202 Peptidase_S10_AS
     IPR001563 Peptidase_S10

    Graphical View of Domain Structure for InterPro Entry Q9H3G5

    ProtoNet protein and cluster: Q9H3G5

    2 Blocks protein families:
    IPB001064 Beta and gamma crystallin
    IPB001563 Serine carboxypeptidase (S10)


    UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
    Similarity: Belongs to the peptidase S10 family


    Function
    for CPVL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
    Function: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory
    protease cascade, and trimming of peptides for antigen presentation

    Enzyme Numbers (IUBMB): EC 3.4.16.-1 EC 3.4.162

    miRNA
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    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPVL (see all 7)
    OriGene shRNA RFP: CPVL
    OriGene siRNA: CPVL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPVL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CPVL

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPVL (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CPVL (NM_031311)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for CPVL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPVL

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004185serine-type carboxypeptidase activity IEA--


    CPVL for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cpvl):
     mortality/aging 

    CPVL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CPVL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPVL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CPVL (Q9H3G52, 3 ENSP000002653944) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48515 I2D: score=2 
    NRBF2Q96F243, ENSP000002777464I2D: score=3 STRING: ENSP00000277746
    PLRG1O436603, ENSP000003031914I2D: score=1 STRING: ENSP00000303191
    CTNNBIP1Q9NSA33, ENSP000003664664I2D: score=2 STRING: ENSP00000366466
    SCRIBQ141603I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    CPVL for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPVL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPVL
    Search CenterWatch for drugs/clinical trials and news about CPVL 

    Transcripts
    for CPVL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPVL gene (2 alternative transcripts): 
    NM_019029.2  NM_031311.3  

    Unigene Cluster for CPVL:

    Carboxypeptidase, vitellogenic-like
    Hs.233389  [show with all ESTs]
    Unigene Representative Sequence: AK124472
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265394(uc003szv.3) ENST00000396276(uc003szw.3) ENST00000432534
    ENST00000455893 ENST00000409850(uc003szx.3) ENST00000448959 ENST00000458405
    ENST00000447426 ENST00000488891 ENST00000449801 ENST00000455544 ENST00000437527


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CPVL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPVL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPVL
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPVL (see all 7)
    OriGene shRNA RFP: CPVL
    OriGene siRNA: CPVL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPVL
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPVL (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPVL (see all 2)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CPVL (NM_031311)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPVL

    Additional cDNA sequence: 

    AF106704.2 AF217508.1 AF282617.1 AK075433.1 AK124472.1 AK225545.1 AY358549.1 BC016838.2 

    12 DOTS entries:

    DT.97779238  DT.95114041  DT.101975346  DT.99962670  DT.100024595  DT.100646650  DT.95101996  DT.102833613 
    DT.121109161  DT.91768286  DT.121109262  DT.121109351 

    24/242 AceView cDNA sequences (see all 242):

    CR595924 AI970669 CR597484 NM_019029 NM_031311 CR601820 CB156924 CR593867 
    CB215711 CB530077 AU184992 CR623778 BX369386 CR613388 AL552903 BE671385 
    CR607237 BI825410 AL553224 CR603975 AA234471 BV176947 AI810958 AA435824 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CPVL    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:              -     -                 -                                                               
    SP2:                    -                 -                                                               
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for CPVL

    Expression
    for CPVL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPVL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTAATCGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CPVL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)

    See CPVL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPVL

    SOURCE GeneReport for Unigene cluster: Hs.233389

    UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
    Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney.
    Also expressed in spleen, leukocytes, and placenta

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPVL

    Orthologs
    for CPVL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPVL gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CPVL6
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343275.1(209776-231097)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.228322 Xenopus laevis transcribed sequence with weak similarity more 75.91(n)    BJ621570.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cpvl2 carboxypeptidase, vitellogenic-like 74.15(n)   387531  BC051154.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG45721 , 3 carboxypeptidase C3
    CG45721    		 44(a)3
    53.21(n)1
    46.24(a)1    		   92B33
    423601  NM_142579.31  NP_650836.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons scpl506
    		 serine carboxypeptidase-like 50
    		 32(a)
    		 1 ↔ 1
    		 1(5168596-5170066)
    rice
    (Oryza sativa)    		 Liliopsida Os07g04793001 hypothetical protein 45.13(n)
    33.59(a)    		   4343226  NM_001066169.1  NP_001059634.1 


    ENSEMBL Gene Tree for CPVL (if available)
    TreeFam Gene Tree for CPVL (if available) 

    Paralogs
    for CPVL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPVL gene
    CTSA2  
    3 SIMAP similar genes for CPVL using alignment to 10 protein entries:     CPVL_HUMAN (see all proteins):
    SCPEP1    CTSA    PPGB

    CPVL for paralogs           About GeneDecksing



    Genomic Variants
    for CPVL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2716 NCBI SNPs in CPVL are shown (see all 2716)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425998751,2
    		C,--29034795(+) AAGAT-/TAAG  
                TAAGT     		3 -- ds5001 int10--------
    rs10120901,2
    		C,F,O,H,--29034840(+) ATTGAT/CTCATC 3 -- ds5001 int124Minor allele frequency- C:0.19NS EA NA WA CSA 2294
    rs10348381,2
    		C,F,A,--29034899(+) AGACTT/GTATAC 3 -- int1 ds50017Minor allele frequency- G:0.33NA WA CSA EA 248
    rs10348391,2
    		C,F,A,H,--29034918(+) ATCTTT/GTCCCC 3 -- ds5001 int1 trp322Minor allele frequency- G:0.23NS EA NA WA CSA 2246
    rs1845673081,2
    		--29034933(+) CTATTA/GTAGCT 3 -- ds5001 int10--------
    rs1394826361,2
    		--29034950(+) ATTTAC/TTTGGG 3 -- ds5001 int10--------
    rs1428111721,2
    		--29035196(+) TCATGC/TACTCA 3 -- int1 ds50010--------
    rs1891507081,2
    		--29035205(+) CATGTA/TAATTT 3 -- ds5001 int10--------
    rs730880331,2
    		C,F,--29035240(+) ACAAAA/GGCTCA 3 -- ds5001 int11Minor allele frequency- G:0.03NA 120
    rs119816591,2
    		C,F,H,--29035330(+) TCTGTT/CTTTAC 3 -- ut31 int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CPVL (29034847 - 29235067 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CPVL: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPVL
    DNA2.0 Custom Variant and Variant Library Synthesis for CPVL

    Disorders / Diseases
    for CPVL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPVL for disorders           About GeneDecksing

    OMIM gene information: 609780    OMIM disorders: --

    9 diseases for CPVL:    About MalaCards
    periventricular leukomalacia    leukomalacia    cerebral palsy    diabetic retinopathy
    retinopathy of prematurity    rheumatoid arthritis    nephropathy    cerebritis
    arthritis

    3 diseases from the University of Copenhagen DISEASES database for CPVL:
    Periventricular leukomalacia     Cerebral palsy     Chorioamnionitis
    Human Genome Epidemiology (HuGE) Navigator: CPVL (6 documents)

    Export disorders for CPVL gene to outside databases

    Publications
    for CPVL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPVL gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CPVL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PubMed id 11401439)1, 2, 3, 9 Mahoney J.A.... McKnight A.J. (2001)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients. (PubMed id 21911749)1 Hu C....Jia W. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)

    External Searches for CPVL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CPVL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54504 HGNC: 14399 AceView: CPVL Ensembl:ENSG00000106066 euGenes: HUgn54504
    ECgene: CPVL H-InvDB: CPVL

    Other Databases showing CPVL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPVL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPVL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CPVL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPVL gene:
    Search GeneIP for patents involving CPVL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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