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CPVL Gene

protein-coding   GIFtS: 60
GCID: GC07M029001

Carboxypeptidase, Vitellogenic-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase, Vitellogenic-Like1 2 3     Probable Serine Carboxypeptidase CPVL2
Vitellogenic Carboxypeptidase-Like Protein1 2 3     EC 3.4.16.-3
Carboxypeptidase WUG1 2     VLP3
CP-Mac Carboxypeptidase1 2     hVLP3
VCP-Like Protein2 3     EC 3.4.168
HVLP2 5     

External Ids:    HGNC: 143991   Entrez Gene: 545042   Ensembl: ENSG000001060667   OMIM: 6097805   UniProtKB: Q9H3G53   

Export aliases for CPVL gene to outside databases

Previous GC identifers: GC07M028677 GC07M028743 GC07M028777 GC07M028808 GC07M028917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPVL Gene:
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine
carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from
the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been
determined. At least two alternatively spliced transcripts which encode the same protein have been observed.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CPVL Gene:
CPVL (carboxypeptidase, vitellogenic-like) is a protein-coding gene. Diseases associated with CPVL include periventricular leukomalacia, and leukomalacia. GO annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CTSA.

UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
Function: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an
inflammatory protease cascade, and trimming of peptides for antigen presentation

Gene Wiki entry for CPVL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPVL gene promoter:
         HOXA3   AML1a   CUTL1   POU3F2   C/EBPalpha   Evi-1   S8   IRF-2   POU2F1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CPVL promoter sequence
   Search Chromatin IP Primers for CPVL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPVL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15.1

CPVL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPVL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M029001:  view genomic region     (about GC identifiers)

Start:
29,034,847 bp from pter      End:
29,235,067 bp from pter
Size:
200,221 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 29,085,477-29,236,357     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5 (See protein sequence)
Recommended Name: Probable serine carboxypeptidase CPVL precursor  
Size: 476 amino acids; 54164 Da
Secondary accessions: A4D1A4 Q6UX20 Q8NBL7 Q96AR7 Q9HB41

Explore the universe of human proteins at neXtProt for CPVL: NX_Q9H3G5

Explore proteomics data for CPVL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280, Lys331, Lys423, Lys469
  • Glycosylation2 at Asn81, Asn132, Asn307, Asn346
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CPVL (Q9H3G5)
     TGESYAG  PVGTGFS  NSNLFFW  NLFFWFFPA 


    See CPVL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061902.2  NP_112601.3  

    ENSEMBL proteins: 
     ENSP00000265394   ENSP00000379572   ENSP00000397327   ENSP00000403580   ENSP00000387164  
     ENSP00000409036   ENSP00000417015   ENSP00000395690   ENSP00000413287   ENSP00000412857  
     ENSP00000416555  

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    Novus Biologicals CPVL Protein
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    Cloud-Clone Corp. CLIAs for CPVL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Vitellogenic carboxypeptidase-like protein
    Serine-type carboxypeptidases

    2 InterPro protein domains:
     IPR018202 Peptidase_S10_AS
     IPR001563 Peptidase_S10

    Graphical View of Domain Structure for InterPro Entry Q9H3G5

    ProtoNet protein and cluster: Q9H3G5

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB001563 Serine carboxypeptidase (S10)


    UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
    Similarity: Belongs to the peptidase S10 family


    CPVL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPVL_HUMAN, Q9H3G5
    Function: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an
    inflammatory protease cascade, and trimming of peptides for antigen presentation

         Enzyme Numbers (IUBMB): EC 3.4.16.-1 EC 3.4.162

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004185serine-type carboxypeptidase activity IEA--
         
    CPVL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cpvl):
     mortality/aging 

    CPVL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPVL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPVL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPVL

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    Sino Biological Human cDNA Clone for CPVL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPVL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPVL

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPVL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    CPVL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPVL
    Interactions:

        Search GeneGlobe Interaction Network for CPVL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CPVL (Q9H3G52, 3 ENSP000002653944) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48515 I2D: score=2 
    NRBF2Q96F243, ENSP000002777464I2D: score=3 STRING: ENSP00000277746
    PLRG1O436603, ENSP000003031914I2D: score=1 STRING: ENSP00000303191
    CTNNBIP1Q9NSA33, ENSP000003664664I2D: score=2 STRING: ENSP00000366466
    SCRIBQ141603I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    CPVL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPVL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPVL gene (2 alternative transcripts): 
    NM_019029.2  NM_031311.3  

    Unigene Cluster for CPVL:

    Carboxypeptidase, vitellogenic-like
    Hs.233389  [show with all ESTs]
    Unigene Representative Sequence: AK124472
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265394(uc003szv.3) ENST00000396276(uc003szw.3) ENST00000432534
    ENST00000455893 ENST00000409850(uc003szx.3) ENST00000448959 ENST00000458405
    ENST00000447426 ENST00000488891 ENST00000449801 ENST00000455544 ENST00000437527

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CPVL (NM_031311)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPVL
    Primer
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    OriGene qPCR primer pairs and template standards for CPVL
    OriGene qSTAR qPCR primer pairs in human, mouse for CPVL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPVL
      QuantiTect SYBR Green Assays in human, mouse, rat CPVL
      QuantiFast Probe-based Assays in human, mouse, rat CPVL

    Additional mRNA sequence: 

    AF106704.2 AF217508.1 AF282617.1 AK075433.1 AK124472.1 AK225545.1 AY358549.1 BC016838.2 

    12 DOTS entries:

    DT.97779238  DT.95114041  DT.101975346  DT.99962670  DT.100024595  DT.100646650  DT.95101996  DT.102833613 
    DT.121109161  DT.91768286  DT.121109262  DT.121109351 

    Selected AceView cDNA sequences (see all 242):

    AA446391 AI810958 BX330568 CR607237 CR624622 AA435824 C02411 BV176947 
    CR603975 AL553224 AA234471 CR600754 BI825410 CR625045 F04717 CR625865 
    CR623624 CR603250 BI523887 BI753175 BC016838 CR596105 CR613388 BE671385 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CPVL    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:              -     -                 -                                                               
    SP2:                    -                 -                                                               
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for CPVL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPVL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAATCGAT
    CPVL Expression
    About this image


    CPVL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Neurons
             Midbrain dopaminergic-like neurons
    CPVL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPVL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.233389

    UniProtKB/Swiss-Prot: CPVL_HUMAN, Q9H3G5
    Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and
    kidney. Also expressed in spleen, leukocytes, and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPVL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPVL gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpvl1 , 5 carboxypeptidase, vitellogenic-like1, 5 79.18(n)1
    76.37(a)1
      6 (26.19 cM)5
    712871  NM_027749.11  NP_082025.11 
     538733795 
    lizard
    (Anolis carolinensis)
    Reptilia CPVL6
    carboxypeptidase, vitellogenic-like
    50(a)
    1 ↔ 1
    GL343275.1(193732-231934)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.228322 Xenopus laevis transcribed sequence with weak similarity more 75.91(n)    BJ621570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpvl2 carboxypeptidase, vitellogenic-like 74.15(n)   387531  BC051154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45721 , 3 carboxypeptidase C3
    CG45721
    44(a)3
    53.13(n)1
    46.01(a)1
      92B33
    423601  NM_142579.41  NP_650836.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    PRC16
    Putative serine type carboxypeptidase with a role ...
    Vacuolar carboxypeptidase Y (proteinase C; CPY), b...
    21(a)
    20(a)
    many ↔ many
    many ↔ many
    II(515664-517190) YBR139W
    XIII(861922-863520) YMR297W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons scpl501 scpl50 48(n)
    37.08(a)
      838065  NM_101369.2  NP_172953.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02151001 Os01g0215100 45.97(n)
    35.11(a)
      4325261  NM_001048929.1  NP_001042394.1 


    ENSEMBL Gene Tree for CPVL (if available)
    TreeFam Gene Tree for CPVL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPVL gene
    CTSA2  
    3 SIMAP similar genes for CPVL using alignment to 10 protein entries:     CPVL_HUMAN (see all proteins):
    CTSA    SCPEP1    PPGB

    CPVL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPVL (see all 2707)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106013231,2
    C--29024620(+) GGGGG-/G/GG  
            
    TGCTA
    2 -- int1 trp31NA 2
    rs732981871,2
    C,F--29053501(+) ATAAAA/GGGCCT 2 -- int14Minor allele frequency- G:0.08WA CSA 124
    rs1382458921,2
    --29053577(+) TTGTCC/TGGCCT 2 -- int10--------
    rs1438541241,2
    --29053615(+) CCAGTA/CTTGCT 2 -- int10--------
    rs1480693541,2
    --29053690(+) AGTGCC/TTGCTT 2 -- int10--------
    rs1417237591,2
    C--29053848(+) GAACCC/TGTGAA 2 -- int10--------
    rs42579181,2
    C,F,A,H--29053849(+) AACCCG/ATGAAA 2 -- int113Minor allele frequency- A:0.20NA NS EA WA CSA 925
    rs1847887201,2
    C--29053880(+) AAGGCA/GACTGC 2 -- int10--------
    rs1505746081,2
    C--29053914(+) TTTGCC/TGATTT 2 -- int10--------
    rs2014475281,2
    --29053939(+) AAGCT-/TTTTG 
            
    TTTTG
    2 -- int10--------

    HapMap Linkage Disequilibrium report for CPVL (29034847 - 29235067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CPVL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734180CNV Deletion23290073
    esv2734179CNV Deletion23290073
    esv2734181CNV Deletion23290073
    esv2173744CNV Deletion18987734
    esv267722CNV Insertion20981092
    esv270163CNV Insertion20981092
    nsv525084CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609780    OMIM disorders: --

    15 diseases for CPVL:    
    About MalaCards
    periventricular leukomalacia    leukomalacia    retinopathy of prematurity    chorioamnionitis
    cerebral palsy    diabetic retinopathy    diabetic nephropathy    cerebritis
    type 1 diabetes    rheumatoid arthritis    arthritis    tonsillitis
    thyroiditis    malaria    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for CPVL:
    Periventricular leukomalacia     Cerebral palsy     Chorioamnionitis     Retinopathy of prematurity

    CPVL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPVL
    Human Genome Epidemiology (HuGE) Navigator: CPVL (6 documents)

    Export disorders for CPVL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPVL gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CPVL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PubMed id 11401439)1, 2, 3, 9 Mahoney J.A.... McKnight A.J. (Genomics 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PubMed id 20460425)1, 4 Maeda S....Nakamura Y. (Diabetes 2010)
    4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)1, 4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54504 HGNC: 14399 AceView: CPVL Ensembl:ENSG00000106066 euGenes: HUgn54504
    ECgene: CPVL H-InvDB: CPVL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPVL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPVL gene:
    Search GeneIP for patents involving CPVL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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