CPT1B Gene

Aliases
for CPT1B gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC22U990008 GC22M047513 GC22M049140 GC22M049143 GC22M049145 GC22M049299 GC22M049300 GC22M049354 GC22M033899

Summaries
for CPT1B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CPT1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10  NC_018933.2  NT_011526.8  

SwitchGear Promoter luciferase reporter plasmids (see all 3): CPT1B promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPT1B

CPT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M051008:  view genomic region     (about GC identifiers)

Proteins
for CPT1B gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CPT1B: NX_Q92523

Explore proteomics data for CPT1B at MOPED

Post-translational modifications: 

CPT1B Human Recombinant Protein Products:

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Domains /
Families
for CPT1B gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q92523

Find genes that share domains with CPT1B           About GenesLikeMe

Function
for CPT1B gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Cpt1b)

genOway: Develop your customized and physiologically relevant rodent model for CPT1B

miRNA Products:		miRTarBase miRNAs that target CPT1B: hsa-mir-1229-3p (MIRT036268), hsa-mir-335-5p (MIRT017237)
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		1 qRT-PCR Assays for microRNA that regulate CPT1B:
		hsa-miR-1207-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CPT1B 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat CPT1B

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CPT1B

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPT1B

Localization
for CPT1B gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for CPT1B gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CPT1B About   (see all 13)   See pathways by source

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	SuperPath	Contained pathways About
1	Fatty acid, triacylglycerol, and ketone body metabolism	Fatty acid, triacylglycerol, and ketone body metabolism 0.65 Import of palmitoyl-CoA into the mitochondrial matrix 0.00
2	Fatty acid metabolism	Fatty acid metabolism 0.42 Fatty acid degradation 0.42
3	Metabolism	Metabolism 0.38 Metabolism of lipids and lipoproteins 0.37
4	Immune response Function of MEF2 in T lymphocytes	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis 0.36
5	Mitochondrial LC-Fatty Acid Beta-Oxidation	Fatty Acid Beta Oxidation 0.35

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CPT1B

AMPK Enzyme Complex Pathway

2 GeneGo (Thomson Reuters) Pathways for CPT1B

	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development Leptin signaling via PI3K-dependent pathway

5 BioSystems Pathways for CPT1B

	AMPK signaling
	Fatty Acid Beta Oxidation
	FOXA2 and FOXA3 transcription factor networks
	phosphatidylethanolamine biosynthesis II
	phosphatidylcholine biosynthesis I

1 Reactome Pathway for CPT1B

Import of palmitoyl-CoA into the mitochondrial matrix

4 Kegg Pathways  (Kegg details for CPT1B)

	Fatty acid degradation
	Fatty acid metabolism
	PPAR signaling pathway
	Adipocytokine signaling pathway

    Pathway & Disease-focused RT² Profiler PCR Arrays including CPT1B: 

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for CPT1B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CPT1B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CPT1B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CPT1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGGGACTTGT

About this image

Adipose (Muscoskeletal System)    fully expand to see all 3 entries
Thoracic Perivascular Adipose
Brown adipocyte-like cells
Bone (Muscoskeletal System)
Bone Marrow
Heart (Cardiovascular System)
Lung (Respiratory System)
Spleen (Hematopoietic System)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPT1B

Orthologs
for CPT1B gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CPT1B gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CPT1B gene

CROT²  CPT1C²  CRAT²  CPT1A²  CHAT²  

5 SIMAP similar genes for CPT1B using alignment to 6 protein entries:     CPT1B_HUMAN (see all proteins):

CPT1A    CPT1C    ChAT    CRAT    CHAT

Find genes that share paralogs with CPT1B           About GenesLikeMe

Genomic Variants
for CPT1B gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CPT1B (see all 455)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1393379561,2	C	--	34949800(+)	AGCCTA/GGCCAA	7	--	ds5001		0	--	--	--	--
rs1440899131,2	C	--	34949851(+)	GCCGGA/GCGTGA	7	--	ds5001		0	--	--	--	--
rs1465225751,2		--	34949852(+)	CCGGGC/TGTGAT	7	--	ds5001		0	--	--	--	--
rs1845113641,2		--	34949860(+)	GATGGC/TGGGCG	7	--	ds5001		0	--	--	--	--
rs1486834711,2	C	--	34949905(+)	AGAATC/TGCTTG	7	--	ds5001		0	--	--	--	--
rs1885165261,2		--	34949908(+)	ATCGCC/TTGAAC	7	--	ds5001		0	--	--	--	--
rs1422750431,2		--	34949987(+)	ACTCCA/GCCTTA	7	--	ds5001		0	--	--	--	--
rs57709051,2	C,F,A,H	--	34949991(+)	CGCCTC/TAAAAA	7	--	ds5001		12		NS EA WA NA CSA	783
rs1812367091,2		--	34950089(+)	TCCTGC/TGTGCC	7	--	ds5001		0	--	--	--	--
rs1129721491,2	C,F	--	34950099(+)	CCTCTT/CGCAGA	7	--	ds5001		3		CSA WA	121
rs1174916201,2	F	--	34950181(+)	GGGCCC/TGTGCA	7	--	ds5001		1		EA	120
rs1848962961,2		--	34950360(+)	GCCTAC/TGTCAC	7	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CPT1B (51007290 - 51017899 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CPT1B (see all 15):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv914559	CNV	Loss	21882294
nsv915495	CNV	Loss	21882294
nsv914561	CNV	Loss	21882294
dgv5062n71	CNV	Loss	21882294
dgv5068n71	CNV	Loss	21882294
esv33185	CNV	Loss	17666407
nsv914525	CNV	Loss	21882294
nsv914543	CNV	Loss	21882294
nsv834239	CNV	Loss	17160897
dgv5066n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): CPT1B

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CPT1B

DNA2.0 Custom Variant and Variant Library Synthesis for CPT1B

Disorders / Diseases
for CPT1B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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3 diseases for CPT1B

2 Novoseek inferred disease relationships for CPT1B gene    About this table

Publications
for CPT1B gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CPT1B gene, integrated from 10 sources (see all 82): (articles sorted by number of sources associating them with CPT1B)

Utopia: connect your pdf to the dynamic world of online information

1. Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). (PubMed id 9070950)^{1, 2, 3, 9} Britton C.H.... McGarry J.D. (Genomics 1997)
2. Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men. (PubMed id 19553926)^{1, 4, 9} Miljkovic I....Zmuda J.M. (Obesity (Silver Spring) 2009)
3. Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians. (PubMed id 17089095)^{1, 4, 9} Robitaille J....Vohl M.C. (J. Mol. Med. 2007)
4. Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I. (PubMed id 9224698)^{1, 2, 9} Yamazaki N....Terada H. (FEBS Lett. 1997)
5. Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. (PubMed id 9199240)^{1, 2, 9} van der Leij F.R....Kuipers J.R.G. (Biochim. Biophys. Acta 1997)
6. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)^{1, 2, 9} Hirosawa M.... Ohara O. (DNA Res. 2001)
7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
9. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). (PubMed id 19404393)^{1, 4} Miyagawa T....Tokunaga K. (PLoS ONE 2009)
10. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)^{1, 4} RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)

External Searches for CPT1B gene

Genome Databases showing CPT1B gene

Other Databases showing CPT1B gene

Specialized Databases showing CPT1B gene

Products
for CPT1B gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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