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CPSF7 Gene

protein-coding   GIFtS: 49
GCID: GC11M061170

Cleavage And Polyadenylation Specific Factor 7, 59kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cleavage And Polyadenylation Specific Factor 7, 59kDa1 2     59 KDa Subunit1
Cleavage Factor Im Complex 59 KDa Subunit1 2     Pre MRNA Cleavage Factor I1
Cleavage And Polyadenylation Specificity Factor 59 KDa Subunit2 3     Cleavage And Polyadenylation Specificity Factor Subunit 72
Pre-MRNA Cleavage Factor Im 59 KDa Subunit2 3     Pre MRNA Cleavage Factor I, 59 KDa Subunit2
CFIm592 3     Pre-MRNA Cleavage Factor I, 59 KDa Subunit2
CPSF 59 KDa Subunit2 3     

External Ids:    HGNC: 300981   Entrez Gene: 798692   Ensembl: ENSG000001495327   UniProtKB: Q8N6843   

Export aliases for CPSF7 gene to outside databases

Previous GC identifers: GC11M060928 GC11M057498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CPSF7 Gene:
CPSF7 (cleavage and polyadenylation specific factor 7, 59kDa) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPSF6.

UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing.
Binds to cleavage and polyadenylation RNA substrates

Gene Wiki entry for CPSF7 (FLJ12529) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CPSF7 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CPSF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CPSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061170:  view genomic region     (about GC identifiers)

Start:
61,170,120 bp from pter      End:
61,197,503 bp from pter
Size:
27,384 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 7  
Size: 471 amino acids; 52050 Da
Subunit: Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or
CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and
is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5
Sequence caution: Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97884.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CPSF7:
3N9U (3D)    
Secondary accessions: B3KU04 C9K0Q4 Q7Z3H9 Q9H025 Q9H9V1
Alternative splicing: 3 isoforms:  Q8N684-1   Q8N684-2   Q8N684-3   

Explore the universe of human proteins at neXtProt for CPSF7: NX_Q8N684

Explore proteomics data for CPSF7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys148, Lys379
  • Modification sites at PhosphoSitePlus

  • See CPSF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129512.1  NP_001136037.1  NP_079087.3  

    ENSEMBL proteins: 
     ENSP00000345412   ENSP00000378352   ENSP00000397203   ENSP00000407394   ENSP00000437860  
     ENSP00000438381   ENSP00000446193   ENSP00000440414   ENSP00000437531   ENSP00000393828  
     ENSP00000442819   ENSP00000443504   ENSP00000446330   ENSP00000437467   ENSP00000391359  
     ENSP00000392400   ENSP00000414295   ENSP00000437768  
    Reactome Protein details: Q8N684

    CPSF7 Human Recombinant Protein Products:

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    OriGene Purified Protein for CPSF7
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    Novus Biologicals CPSF7 Protein
    Novus Biologicals CPSF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPSF7

     
    Search eBioscience for Proteins for CPSF7 

     
    antibodies-online proteins for CPSF7 (2 products) 

     
    antibodies-online peptides for CPSF7

    CPSF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for CPSF7 (5 products) 

    CPSF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CPSF7
    Cloud-Clone Corp. CLIAs for CPSF7
    Search eBioscience for ELISAs for CPSF7 
    antibodies-online kits for CPSF7 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8N684

    ProtoNet protein and cluster: Q8N684

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
    Similarity: Belongs to the RRM CPSF6/7 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with CPSF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPSF7_HUMAN, Q8N684
    Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing.
    Binds to cleavage and polyadenylation RNA substrates

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI16713569
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CPSF7           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CPSF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPSF7:
    hsa-mir-16-5p (MIRT031997), hsa-mir-23b-3p (MIRT046265), hsa-mir-378a-3p (MIRT043890), hsa-mir-484 (MIRT041769), hsa-mir-103a-3p (MIRT027174), hsa-mir-30c-2-3p (MIRT038696)

    Block miRNA regulation of human, mouse, rat CPSF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPSF7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CPSF7 (NM_024811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPSF7
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPSF7_HUMAN, Q8N684: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005849mRNA cleavage factor complex IDA--

    Find genes that share ontologies with CPSF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPSF7 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    2mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with CPSF7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for CPSF7
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for CPSF7):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPSF7
    Interactions:

        Search GeneGlobe Interaction Network for CPSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CPSF7 (Q8N6841, 2, 3 ENSP000003454124) via UniProtKB, MINT, STRING, and/or I2D (see all 893)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT21O438092, 3, ENSP000003002914MINT-66942 MINT-7947479 I2D: score=5 STRING: ENSP00000300291
    DVL2O146412, 3, ENSP000000053404MINT-67272 I2D: score=5 STRING: ENSP00000005340
    GCC1Q96CN92, 3, ENSP000003188214MINT-67470 I2D: score=5 STRING: ENSP00000318821
    NCK2O436392, 3, ENSP000002331544MINT-68386 I2D: score=5 STRING: ENSP00000233154
    CLP1Q929892, 3, ENSP000003047044MINT-7945693 I2D: score=1 STRING: ENSP00000304704
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with CPSF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPSF7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPSF7 gene (3 alternative transcripts): 
    NM_001136040.2  NM_001142565.1  NM_024811.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000340437(uc001nrp.3) ENST00000394888(uc001nrq.3 uc001nrr.3)
    ENST00000439958 ENST00000494016 ENST00000448745 ENST00000537641 ENST00000477890
    ENST00000544669(uc001nrs.1 uc009ynp.2) ENST00000539952 ENST00000535222
    ENST00000544990 ENST00000544585 ENST00000413232 ENST00000537162 ENST00000543545
    ENST00000541963 ENST00000536548 ENST00000450000
    miRNA
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    Block miRNA regulation of human, mouse, rat CPSF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
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    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for CPSF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CPSF7 (NM_024811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPSF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF7
    Primer
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    OriGene qPCR primer pairs and template standards for CPSF7
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPSF7
      QuantiTect SYBR Green Assays in human, mouse, rat CPSF7
      QuantiFast Probe-based Assays in human, mouse, rat CPSF7

    Selected AceView cDNA sequences (see all 354):

    AI567566 AI468890 AA342593 CA416895 AL535516 AA172064 AI564568 BX509132 
    CR601865 CA449866 BX361249 BQ009491 BQ680004 AA837449 AA397844 AA279821 
    BQ018366 BQ677992 BQ774963 AI439221 BM561596 AI066791 AI674899 NM_024811 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPSF7 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
    SP1:                                                                                      -           -     -           -     -                                 
    SP2:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP3:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP4:                                                        -     -     -     -           -           -     -     -     -     -                                 
    SP5:                                -     -     -     -     -     -     -     -           -           -           -     -     -                                 

    ExUns: 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
    SP1:                          -                       -     -     -     -                       -                                   -                     
    SP2:                          -                                                                 -                                   -                     
    SP3:                                                                                            -                                   -                     
    SP4:                                                                                            -                                   -                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CPSF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CPSF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCCCACC
    CPSF7 Expression
    About this image

    CPSF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPSF7 Protein Expression
        Custom PCR Arrays for CPSF7
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    QuantiFast Probe-based Assays in human, mouse, rat CPSF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPSF7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpsf71 , 5 cleavage and polyadenylation specific factor 71, 5 93.49(n)1
    98.73(a)1
      19 (6.60 cM)5
    2690611  NM_172302.31  NP_758506.31 
     105252445 
    chicken
    (Gallus gallus)
    Aves CPSF71 cleavage and polyadenylation specific factor 7, 59kDa 78.37(n)
    86.8(a)
      426014  XM_003641271.2  XP_003641319.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67592 Transcribed sequence with weak similarity to protein more 73.33(n)    CF240377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpsf61 cleavage and polyadenylation specific factor 6 58.5(n)
    53.94(a)
      327069  NM_001017993.1  NP_001017993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71856
    --
    30(a)
    1 → many
    3L(8303593-8308602)
    worm
    (Caenorhabditis elegans)
    Secernentea cfim-26
    Protein CFIM-2, isoform b
    27(a)
    1 → many
    IV(8926335-8930345) WBGene00008362


    ENSEMBL Gene Tree for CPSF7 (if available)
    TreeFam Gene Tree for CPSF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPSF7 gene
    CPSF62  
    1 SIMAP similar gene for CPSF7 using alignment to 14 protein entries:     CPSF7_HUMAN (see all proteins):
    CPSF6

    Find genes that share paralogs with CPSF7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPSF7 (see all 459)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904271051,2
    --61169686(+) TTGTAA/GGTGAA 3 -- int10--------
    rs1495070041,2
    C--61169885(+) CTTAGA/GAGTTT 3 -- int10--------
    rs112306871,2
    C,F,H--61169974(+) TCTTAG/AGAGGC 3 -- int119Minor allele frequency- A:0.14NS EA NA WA CSA 1644
    rs1498406291,2
    C--61170003(+) CCATG-/TGTATC 3 -- int10--------
    rs1822124561,2
    --61170208(+) GACAGC/TGTCAT 3 -- ut310--------
    rs1871719821,2
    --61170269(+) ACAACA/GGGGGG 3 -- ut310--------
    rs1911916151,2
    --61170276(+) GGGGAC/TGGGAC 3 -- ut310--------
    rs1175654071,2
    C,F--61170392(+) TCTCCG/AGGTAA 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs1395603331,2
    C--61170442(+) TGTCA-/CCTTTT 3 -- ut310--------
    rs1808192901,2
    --61170645(+) GACTGA/GGGGCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CPSF7 (61170120 - 61197503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPSF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897603CNV Loss21882294
    nsv520751CNV Gain19592680
    nsv832178CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPSF7
    DNA2.0 Custom Variant and Variant Library Synthesis for CPSF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPSF7 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with CPSF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (Genes Cells 2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. (PubMed id 8626397)1, 2 Rueegsegger U.... Keller W. (J. Biol. Chem. 1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79869 HGNC: 30098 AceView: FLJ12529 Ensembl:ENSG00000149532 euGenes: HUgn79869
    ECgene: CPSF7 Kegg: 79869 H-InvDB: CPSF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPSF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPSF7 gene:
    Search GeneIP for patents involving CPSF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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