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Aliases for CPSF7 Gene

Aliases for CPSF7 Gene

  • Cleavage And Polyadenylation Specific Factor 7 2 3 5
  • Cleavage And Polyadenylation Specificity Factor 59 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 7, 59kDa 2 3
  • Pre-MRNA Cleavage Factor Im 59 KDa Subunit 3 4
  • Cleavage Factor Im Complex 59 KDa Subunit 2 3
  • CPSF 59 KDa Subunit 3 4
  • CFIm59 3 4
  • Pre-MRNA Cleavage Factor I, 59 KDa Subunit 3
  • Pre MRNA Cleavage Factor I, 59 KDa Subunit 3
  • Pre MRNA Cleavage Factor I 2
  • 59 KDa Subunit 2

External Ids for CPSF7 Gene

Previous GeneCards Identifiers for CPSF7 Gene

  • GC11M060928
  • GC11M061170
  • GC11M057498

Summaries for CPSF7 Gene

GeneCards Summary for CPSF7 Gene

CPSF7 (Cleavage And Polyadenylation Specific Factor 7) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPSF6.

UniProtKB/Swiss-Prot for CPSF7 Gene

  • Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Binds to cleavage and polyadenylation RNA substrates.

Gene Wiki entry for CPSF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF7 Gene

Genomics for CPSF7 Gene

Regulatory Elements for CPSF7 Gene

Genomic Location for CPSF7 Gene

Chromosome:
11
Start:
61,402,641 bp from pter
End:
61,430,031 bp from pter
Size:
27,391 bases
Orientation:
Minus strand

Genomic View for CPSF7 Gene

Genes around CPSF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF7 Gene

Proteins for CPSF7 Gene

  • Protein details for CPSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N684-CPSF7_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 7
    Protein Accession:
    Q8N684
    Secondary Accessions:
    • B3KU04
    • C9K0Q4
    • Q7Z3H9
    • Q9H025
    • Q9H9V1

    Protein attributes for CPSF7 Gene

    Size:
    471 amino acids
    Molecular mass:
    52050 Da
    Quaternary structure:
    • Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5.
    SequenceCaution:
    • Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPSF7 Gene

    Alternative splice isoforms for CPSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF7 Gene

Proteomics data for CPSF7 Gene at MOPED

Post-translational modifications for CPSF7 Gene

  • Ubiquitination at Lys 148 and Lys 379
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CPSF7 Gene

Domains & Families for CPSF7 Gene

Gene Families for CPSF7 Gene

Protein Domains for CPSF7 Gene

Suggested Antigen Peptide Sequences for CPSF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N684

UniProtKB/Swiss-Prot:

CPSF7_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM CPSF6/7 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM CPSF6/7 family.
genes like me logo Genes that share domains with CPSF7: view

Function for CPSF7 Gene

Molecular function for CPSF7 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Binds to cleavage and polyadenylation RNA substrates.

Gene Ontology (GO) - Molecular Function for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with CPSF7: view

Phenotypes for CPSF7 Gene

genes like me logo Genes that share phenotypes with CPSF7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF7 Gene

Localization for CPSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF7 Gene COMPARTMENTS Subcellular localization image for CPSF7 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005849 mRNA cleavage factor complex IDA 20695905
genes like me logo Genes that share ontologies with CPSF7: view

Pathways & Interactions for CPSF7 Gene

genes like me logo Genes that share pathways with CPSF7: view

Pathways by source for CPSF7 Gene

Gene Ontology (GO) - Biological Process for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CPSF7: view

No data available for SIGNOR curated interactions for CPSF7 Gene

Drugs & Compounds for CPSF7 Gene

No Compound Related Data Available

Transcripts for CPSF7 Gene

Unigene Clusters for CPSF7 Gene

Cleavage and polyadenylation specific factor 7, 59kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - - - - - -
SP18: - - - - - - -
SP19: - - - - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - - -
SP22:
SP23: - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - -
SP26:
SP27:
SP28:

ExUns: 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -
SP7: -
SP8:
SP9: -
SP10: -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: -
SP21:
SP22:
SP23: - - - - -
SP24:
SP25:
SP26:
SP27:
SP28:

Relevant External Links for CPSF7 Gene

GeneLoc Exon Structure for
CPSF7
ECgene alternative splicing isoforms for
CPSF7

Expression for CPSF7 Gene

mRNA expression in normal human tissues for CPSF7 Gene

Protein differential expression in normal tissues from HIPED for CPSF7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.0), Nasal epithelium (8.4), and Lymph node (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF7 Gene



SOURCE GeneReport for Unigene cluster for CPSF7 Gene Hs.718984

genes like me logo Genes that share expression patterns with CPSF7: view

Protein tissue co-expression partners for CPSF7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF7 Gene

Orthologs for CPSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPSF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF7 35
  • 95.4 (n)
  • 99.79 (a)
CPSF7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF7 35
  • 95.47 (n)
  • 99.58 (a)
CPSF7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf7 35
  • 93.49 (n)
  • 98.73 (a)
Cpsf7 16
Cpsf7 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF7 35
  • 99.61 (n)
  • 99.61 (a)
CPSF7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf7 35
  • 92.47 (n)
  • 98.43 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF7 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF7 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF7 35
  • 78.37 (n)
  • 86.8 (a)
CPSF7 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6759 35
zebrafish
(Danio rerio)
Actinopterygii cpsf6 35
  • 58.5 (n)
  • 53.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7185 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfim-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CPSF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF7 Gene

ENSEMBL:
Gene Tree for CPSF7 (if available)
TreeFam:
Gene Tree for CPSF7 (if available)

Paralogs for CPSF7 Gene

Paralogs for CPSF7 Gene

genes like me logo Genes that share paralogs with CPSF7: view

Variants for CPSF7 Gene

Sequence variations from dbSNP and Humsavar for CPSF7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs921635 -- 61,405,864(+) ACCTA(C/T)GCAGG intron-variant
rs921636 -- 61,406,142(+) AGCCA(C/T)AGCAC intron-variant
rs1058020 -- 61,402,832(-) AAAAC(A/C)CCCAT utr-variant-3-prime
rs1058021 -- 61,402,772(-) TCTTT(C/T)TGATA utr-variant-3-prime
rs1064377 -- 61,415,699(-) GCAGT(C/G)CCATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CPSF7 Gene

Variant ID Type Subtype PubMed ID
nsv520751 CNV Gain 19592680
nsv832178 CNV Gain+Loss 17160897
nsv897603 CNV Loss 21882294

Variation tolerance for CPSF7 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF7 Gene

HapMap Linkage Disequilibrium report
CPSF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF7 Gene

Disorders for CPSF7 Gene

Relevant External Links for CPSF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF7

No disorders were found for CPSF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF7 Gene

Publications for CPSF7 Gene

  1. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PMID: 20695905) Kim S. … Yamaguchi Y. (Genes Cells 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CPSF7 Gene

Sources for CPSF7 Gene

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