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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPSF7 Gene

protein-coding   GIFtS: 50
GCID: GC11M061170

cleavage and polyadenylation specific factor 7, 59kDa
 Explore 4 diseases affiliated with
CPSF7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPSF7    

Aliases
for CPSF7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cleavage And Polyadenylation Specific Factor 7, 59kDa1 2     FLJ125291
Cleavage And Polyadenylation Specificity Factor 59 KDa Subunit2 3     Cleavage And Polyadenylation Specificity Factor Subunit 72
Pre-MRNA Cleavage Factor Im 59 KDa Subunit2 3     Pre MRNA Cleavage Factor I, 59 KDa Subunit2
CFIm592 3     Pre-MRNA Cleavage Factor I, 59 KDa Subunit2
CPSF 59 KDa Subunit2 3     

External Ids:    HGNC: 300981   Entrez Gene: 798692   Ensembl: ENSG000001495327   UniProtKB: Q8N6843   

Export aliases for CPSF7 gene to outside databases

Previous GC identifers: GC11M060928 GC11M057498


Summaries
for CPSF7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing. Binds to
cleavage and polyadenylation RNA substrates

Gene Wiki entry for CPSF7 (FLJ12529)


Genomic Views
for CPSF7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPSF7 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPSF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPSF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CPSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061170:  view genomic region     (about GC identifiers)

Start:
 61,170,120 bp from pter      End:
 61,197,503 bp from pter
Size:
 27,384 bases      Orientation:
 minus strand

Proteins
for CPSF7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 7  
Size: 471 amino acids; 52050 Da
Subunit: Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7.
Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped
by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97884.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CPSF7:
3N9U (3D)    
Secondary accessions: B3KU04 C9K0Q4 Q7Z3H9 Q9H025 Q9H9V1
Alternative splicing: 3 isoforms:  Q8N684-1   Q8N684-2   Q8N684-3   

Explore the universe of human proteins at neXtProt for CPSF7: NX_Q8N684

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N684

    • CPSF7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129512.1  NP_001136037.1  NP_079087.3  

    ENSEMBL proteins: 
     ENSP00000345412   ENSP00000378352   ENSP00000397203   ENSP00000407394   ENSP00000441868  
     ENSP00000437860   ENSP00000438381   ENSP00000446193   ENSP00000440414   ENSP00000437531  
     ENSP00000393828   ENSP00000442819   ENSP00000443504   ENSP00000446330   ENSP00000437467  
     ENSP00000391359   ENSP00000392400   ENSP00000414295   ENSP00000437768  
    Reactome Protein details: Q8N684
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: CPSF7
    OriGene Protein Over-expression Lysate (see all 2): CPSF7
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    Novus Biologicals CPSF7 Protein
    Novus Biologicals CPSF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPSF7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005849mRNA cleavage factor complex IDA--


    CPSF7 for ontologies           About GeneDecksing



    CPSF7 Antibody Products: 
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    Novus Biologicals CPSF7 Antibodies
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    Uscn Antibodies for CPSF7
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    Assay Products for CPSF7: 
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    Uscn ELISAs and CLIAs for CPSF7

    Protein Domains /
    Families
    for CPSF7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPSF7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8N684

    ProtoNet protein and cluster: Q8N684

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
    Similarity: Belongs to the RRM CPSF6/7 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for CPSF7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
    Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing. Binds to
    cleavage and polyadenylation RNA substrates

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPSF7
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CPSF7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPSF7 (see all 4)
    OriGene shRNA RFP: CPSF7
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPSF7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CPSF7

    Clone
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    Search LifeMap BioReagents cell lines for CPSF7

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16713569


    CPSF7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CPSF7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    		Post-Elongation Processing of the Transcript1.00
    		mRNA 3'-end processing0.79
    		Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		mRNA Splicing - Major Pathway1.00
    		mRNA Processing0.82
    3Post-Elongation Processing of Intronless pre-mRNA
    		Processing of Capped Intronless Pre-mRNA1.00
    		Processing of Intronless Pre-mRNAs0.61
    		Post-Elongation Processing of Intronless pre-mRNA1.00
    4Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    5mRNA surveillance pathway
    		mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/15        Reactome Pathways for CPSF7 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CPSF7):
        mRNA surveillance pathway


    CPSF7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/803 Interacting proteins for CPSF7 (Q8N6841, 2, 3 ENSP000003454124) via UniProtKB, MINT, STRING, and/or I2D (see all 803)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT21O438092, 3, ENSP000003002914MINT-66942 MINT-7947479 I2D: score=5 STRING: ENSP00000300291
    DVL2O146412, 3, ENSP000000053404MINT-67272 I2D: score=5 STRING: ENSP00000005340
    GCC1Q96CN92, 3, ENSP000003188214MINT-67470 I2D: score=5 STRING: ENSP00000318821
    NCK2O436392, 3, ENSP000002331544MINT-68386 I2D: score=5 STRING: ENSP00000233154
    CLP1Q929892, 3, ENSP000003047044MINT-7945693 I2D: score=1 STRING: ENSP00000304704
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS--
    GO:0008380RNA splicing TAS--


    CPSF7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPSF7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPSF7
    Search CenterWatch for drugs/clinical trials and news about CPSF7 

    Transcripts
    for CPSF7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPSF7 gene (3 alternative transcripts): 
    NM_001136040.2  NM_001142565.1  NM_024811.3  

    Unigene Cluster for CPSF7:

    Cleavage and polyadenylation specific factor 7, 59kDa
    Hs.718984  [show with all ESTs]
    Unigene Representative Sequence: NM_024811
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000340437(uc001nrp.3) ENST00000394888(uc001nrq.3 uc001nrr.3)
    ENST00000439958 ENST00000494016 ENST00000448745 ENST00000537641 ENST00000544147
    ENST00000477890 ENST00000544669(uc001nrs.1 uc009ynp.2) ENST00000539952
    ENST00000535222 ENST00000544990 ENST00000544585 ENST00000413232 ENST00000537162
    ENST00000543545 ENST00000541963 ENST00000536548

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CPSF7
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPSF7
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CPSF7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPSF7 (see all 4)
    OriGene shRNA RFP: CPSF7
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPSF7
    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ275970.1 AK022591.1 AK096343.1 AK294578.1 AK307190.1 AL512759.1 AL832546.1 AL832667.1 
    AL833332.1 BC018135.1 BX537888.1 

    24/33 DOTS entries (see all 33):

    DT.100796630  DT.101984226  DT.100796629  DT.443264  DT.100680766  DT.95287901  DT.40256331  DT.95264122 
    DT.100796639  DT.91763448  DT.91763449  DT.100796633  DT.120728908  DT.91662897  DT.91763443  DT.91792048 
    DT.95230513  DT.100722846  DT.102833336  DT.102833337  DT.120728916  DT.431613  DT.91678006  DT.100708438 

    24/354 AceView cDNA sequences (see all 354):

    AU154723 BQ677992 AI468890 BM561596 CA416895 CR601865 BM744346 AK096343 
    BU689129 BP377639 AL512759 BQ774963 BQ680004 AI564568 CA435380 AA326383 
    AL535516 BU185553 BC018135 BE220069 BQ009491 AI567566 AA580555 BF916879 

    GeneLoc Exon Structure

    5/28 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF7 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
    SP1:                                                                                      -           -     -           -     -                                 
    SP2:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP3:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP4:                                                        -     -     -     -           -           -     -     -     -     -                                 
    SP5:                                -     -     -     -     -     -     -     -           -           -           -     -     -                                 

    ExUns: 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
    SP1:                          -                       -     -     -     -                       -                                   -                     
    SP2:                          -                                                                 -                                   -                     
    SP3:                                                                                            -                                   -                     
    SP4:                                                                                            -                                   -                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CPSF7

    Expression
    for CPSF7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPSF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCCCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CPSF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPSF7

    SOURCE GeneReport for Unigene cluster: Hs.718984
        SABiosciences Custom PCR Arrays for CPSF7
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    Orthologs
    for CPSF7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CPSF7 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPSF71 cleavage and polyadenylation specific factor 7, 59kDa 78.11(n)
    86.78(a)    		   426014  XM_423693.3  XP_423693.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 5(a)
    		 possible ortholog
    		 2(112463496-112464983)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.67592 Transcribed sequence with weak similarity to protein more 73.33(n)    CF240377.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG71856
    		 --
    		 25(a)
    		 1 → many
    		 3L(8303593-8308602)
    worm
    (Caenorhabditis elegans)    		 Secernentea pqn-756
    cfim-26
    (see all 4)    		 Protein CFIM-2, isoform a
    (see all 4)    		 4(a)
    26(a)
    (see all 4)    		 possible ortholog
    1 ↔ many
    (see all 4)    		 IV(4072320-4077629)
    IV(8926322-8930302)


    ENSEMBL Gene Tree for CPSF7 (if available)
    TreeFam Gene Tree for CPSF7 (if available) 

    Paralogs
    for CPSF7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPSF7 gene
    SF3B42  CPSF62  MAPK1IP1L2  
    1 SIMAP similar gene for CPSF7 using alignment to 14 protein entries:     CPSF7_HUMAN (see all proteins):
    CPSF6

    CPSF7 for paralogs           About GeneDecksing



    Genomic Variants
    for CPSF7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 NCBI SNPs in CPSF7 are shown (see all 349)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1904271051,2
    		--61169686(+) TTGTAA/GGTGAA 3 -- int10--------
    rs1495070041,2
    		--61169885(+) CTTAGA/GAGTTT 3 -- int10--------
    rs112306871,2
    		C,F,H,--61169974(+) TCTTAG/AGAGGC 3 -- int119Minor allele frequency- A:0.14NS EA NA WA CSA 1644
    rs1498406291,2
    		C,--61170002(+) CCATG-/TTATCA 3 -- int10--------
    rs1822124561,2
    		--61170208(+) GACAGC/TGTCAT 3 -- ut310--------
    rs1871719821,2
    		--61170269(+) ACAACA/GGGGGG 3 -- ut310--------
    rs1911916151,2
    		--61170276(+) GGGGAC/TGGGAC 3 -- ut310--------
    rs1175654071,2
    		C,F,--61170392(+) TCTCCG/AGGTAA 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs1395603331,2
    		C,--61170442(+) TGTCA-/CCTTTT 3 -- ut310--------
    rs1808192901,2
    		--61170645(+) GACTGA/GGGGCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CPSF7 (61170120 - 61197503 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CPSF7: --

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    Disorders / Diseases
    for CPSF7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPSF7 for disorders           About GeneDecksing

    4 diseases for CPSF7:    About MalaCards
    wiskott-aldrich syndrome    ataxia    tuberculosis    mycobacterium tuberculosis


    Export disorders for CPSF7 gene to outside databases

    Publications
    for CPSF7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPSF7 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CPSF7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. (PubMed id 8626397)1, 2 Rueegsegger U.... Keller W. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for CPSF7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CPSF7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79869 HGNC: 30098 AceView: FLJ12529 Ensembl:ENSG00000149532 euGenes: HUgn79869
    ECgene: CPSF7 Kegg: 79869 H-InvDB: CPSF7

    Other Databases showing CPSF7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPSF7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPSF7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CPSF7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPSF7 gene:
    Search GeneIP for patents involving CPSF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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