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Aliases for CPSF7 Gene

Aliases for CPSF7 Gene

  • Cleavage And Polyadenylation Specific Factor 7, 59kDa 2 3
  • Cleavage And Polyadenylation Specificity Factor 59 KDa Subunit 3 4
  • Pre-MRNA Cleavage Factor Im 59 KDa Subunit 3 4
  • Cleavage Factor Im Complex 59 KDa Subunit 2 3
  • CPSF 59 KDa Subunit 3 4
  • CFIm59 3 4
  • Cleavage And Polyadenylation Specificity Factor Subunit 7 3
  • Pre MRNA Cleavage Factor I, 59 KDa Subunit 3
  • Pre-MRNA Cleavage Factor I, 59 KDa Subunit 3
  • Pre MRNA Cleavage Factor I 2
  • 59 KDa Subunit 2

External Ids for CPSF7 Gene

Summaries for CPSF7 Gene

GeneCards Summary for CPSF7 Gene

CPSF7 (Cleavage And Polyadenylation Specific Factor 7, 59kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPSF6.

UniProtKB/Swiss-Prot for CPSF7 Gene

  • Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Binds to cleavage and polyadenylation RNA substrates.

Gene Wiki entry for CPSF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF7 Gene

Genomics for CPSF7 Gene

Genomic Location for CPSF7 Gene

Start:
61,402,641 bp from pter
End:
61,430,031 bp from pter
Size:
27,391 bases
Orientation:
Minus strand

Genomic View for CPSF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF7 Gene

Regulatory Elements for CPSF7 Gene

Proteins for CPSF7 Gene

  • Protein details for CPSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N684-CPSF7_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 7
    Protein Accession:
    Q8N684
    Secondary Accessions:
    • B3KU04
    • C9K0Q4
    • Q7Z3H9
    • Q9H025
    • Q9H9V1

    Protein attributes for CPSF7 Gene

    Size:
    471 amino acids
    Molecular mass:
    52050 Da
    Quaternary structure:
    • Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5.
    SequenceCaution:
    • Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPSF7 Gene

    Alternative splice isoforms for CPSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF7 Gene

Proteomics data for CPSF7 Gene at MOPED

Post-translational modifications for CPSF7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys148 and Lys379

No data available for DME Specific Peptides for CPSF7 Gene

Domains for CPSF7 Gene

Gene Families for CPSF7 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CPSF7 Gene

UniProtKB/Swiss-Prot:

CPSF7_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q8N684
Family:
  • Belongs to the RRM CPSF6/7 family.:
    • Q8N684
genes like me logo Genes that share domains with CPSF7: view

Function for CPSF7 Gene

Molecular function for CPSF7 Gene

UniProtKB/Swiss-Prot Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Binds to cleavage and polyadenylation RNA substrates.

Gene Ontology (GO) - Molecular Function for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CPSF7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPSF7 Gene

Localization for CPSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF7 Gene COMPARTMENTS Subcellular localization image for CPSF7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20695905
GO:0005654 nucleoplasm TAS --
GO:0005849 mRNA cleavage factor complex IDA 20695905
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CPSF7: view

Pathways for CPSF7 Gene

genes like me logo Genes that share pathways with CPSF7: view

Gene Ontology (GO) - Biological Process for CPSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CPSF7: view

Transcripts for CPSF7 Gene

Unigene Clusters for CPSF7 Gene

Cleavage and polyadenylation specific factor 7, 59kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - - - - - -
SP18: - - - - - - -
SP19: - - - - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - - -
SP22:
SP23: - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - -
SP26:
SP27:
SP28:

ExUns: 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -
SP7: -
SP8:
SP9: -
SP10: -
SP11: - - - - -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: -
SP21:
SP22:
SP23: - - - - -
SP24:
SP25:
SP26:
SP27:
SP28:

Relevant External Links for CPSF7 Gene

GeneLoc Exon Structure for
CPSF7
ECgene alternative splicing isoforms for
CPSF7

Expression for CPSF7 Gene

mRNA expression in normal human tissues for CPSF7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF7 Gene

SOURCE GeneReport for Unigene cluster for CPSF7 Gene Hs.718984

genes like me logo Genes that share expressions with CPSF7: view

Orthologs for CPSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPSF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF7 36
  • 99.61 (n)
  • 99.61 (a)
CPSF7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF7 36
  • 95.4 (n)
  • 99.79 (a)
CPSF7 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF7 36
  • 95.47 (n)
  • 99.58 (a)
CPSF7 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf7 36
  • 93.49 (n)
  • 98.73 (a)
Cpsf7 16
Cpsf7 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF7 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF7 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf7 36
  • 92.47 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves CPSF7 36
  • 78.37 (n)
  • 86.8 (a)
CPSF7 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6759 36
zebrafish
(Danio rerio)
Actinopterygii cpsf6 36
  • 58.5 (n)
  • 53.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7185 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfim-2 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for CPSF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF7 Gene

ENSEMBL:
Gene Tree for CPSF7 (if available)
TreeFam:
Gene Tree for CPSF7 (if available)

Paralogs for CPSF7 Gene

Paralogs for CPSF7 Gene

genes like me logo Genes that share paralogs with CPSF7: view

Variants for CPSF7 Gene

Sequence variations from dbSNP and Humsavar for CPSF7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs896830 -- 61,417,685(+) GCAAC(C/T)GGCTC intron-variant
rs921635 -- 61,405,864(+) ACCTA(C/T)GCAGG intron-variant
rs921636 -- 61,406,142(+) AGCCA(C/T)AGCAC intron-variant
rs1058020 -- 61,402,832(-) AAAAC(A/C)CCCAT utr-variant-3-prime
rs1058021 -- 61,402,772(-) TCTTT(C/T)TGATA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPSF7 Gene

Variant ID Type Subtype PubMed ID
nsv520751 CNV Gain 19592680
nsv832178 CNV Gain+Loss 17160897
nsv897603 CNV Loss 21882294

Relevant External Links for CPSF7 Gene

HapMap Linkage Disequilibrium report
CPSF7

Disorders for CPSF7 Gene

No disorders were found for CPSF7 Gene.

No data available for UniProtKB/Swiss-Prot for CPSF7 Gene

Publications for CPSF7 Gene

  1. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PMID: 20695905) Kim S. … Yamaguchi Y. (Genes Cells 2010) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPSF7 Gene

Sources for CPSF7 Gene

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