Aliases for CPSF7 Gene
External Ids for CPSF7 Gene
Previous GeneCards Identifiers for CPSF7 Gene
Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]
GeneCards Summary for CPSF7 Gene
CPSF7 (Cleavage And Polyadenylation Specific Factor 7) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPSF6.
UniProtKB/Swiss-Prot for CPSF7 Gene
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Binds to cleavage and polyadenylation RNA substrates.