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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPSF7 Gene

protein-coding   GIFtS: 50
GCID: GC11M061170

Cleavage And Polyadenylation Specific Factor 7, 59kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cleavage And Polyadenylation Specific Factor 7, 59kDa1 2     59 KDa Subunit1
Cleavage Factor Im Complex 59 KDa Subunit1 2     Pre MRNA Cleavage Factor I1
Cleavage And Polyadenylation Specificity Factor 59 KDa Subunit2 3     Cleavage And Polyadenylation Specificity Factor Subunit 72
Pre-MRNA Cleavage Factor Im 59 KDa Subunit2 3     Pre MRNA Cleavage Factor I, 59 KDa Subunit2
CFIm592 3     Pre-MRNA Cleavage Factor I, 59 KDa Subunit2
CPSF 59 KDa Subunit2 3     

External Ids:    HGNC: 300981   Entrez Gene: 798692   Ensembl: ENSG000001495327   UniProtKB: Q8N6843   

Export aliases for CPSF7 gene to outside databases

Previous GC identifers: GC11M060928 GC11M057498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CPSF7 Gene: 
CPSF7 (cleavage and polyadenylation specific factor 7, 59kDa) is a protein-coding gene. Diseases associated with CPSF7 include wiskott-aldrich syndrome, and tuberculosis, and among its related super-pathways are Post-Elongation Processing of Intron-Containing pre-mRNA and mRNA Processing. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPSF6.

UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing.
Binds to cleavage and polyadenylation RNA substrates

Gene Wiki entry for CPSF7 (FLJ12529) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPSF7 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CPSF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CPSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061170:  view genomic region     (about GC identifiers)

Start:
61,170,120 bp from pter      End:
61,197,503 bp from pter
Size:
27,384 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 7  
Size: 471 amino acids; 52050 Da
Subunit: Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or
CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and
is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97884.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CPSF7:
3N9U (3D)    
Secondary accessions: B3KU04 C9K0Q4 Q7Z3H9 Q9H025 Q9H9V1
Alternative splicing: 3 isoforms:  Q8N684-1   Q8N684-2   Q8N684-3   

Explore the universe of human proteins at neXtProt for CPSF7: NX_Q8N684

Explore proteomics data for CPSF7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N684

  • CPSF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPSF7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129512.1  NP_001136037.1  NP_079087.3  

    ENSEMBL proteins: 
     ENSP00000345412   ENSP00000378352   ENSP00000397203   ENSP00000407394   ENSP00000437860  
     ENSP00000438381   ENSP00000446193   ENSP00000440414   ENSP00000437531   ENSP00000393828  
     ENSP00000442819   ENSP00000443504   ENSP00000446330   ENSP00000437467   ENSP00000391359  
     ENSP00000392400   ENSP00000414295   ENSP00000437768  
    Reactome Protein details: Q8N684
    Human Recombinant Protein Products for CPSF7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPSF7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005849mRNA cleavage factor complex IDA--

    CPSF7 for ontologies           About GeneDecksing



    CPSF7 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CPSF7 
    Cloud-Clone Corp. CLIAs for CPSF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8N684

    ProtoNet protein and cluster: Q8N684

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CPSF7_HUMAN, Q8N684
    Similarity: Belongs to the RRM CPSF6/7 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    CPSF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPSF7_HUMAN, Q8N684
    Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing.
    Binds to cleavage and polyadenylation RNA substrates

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16713569
         
    CPSF7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPSF7 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPSF7 
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    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPSF7 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    2mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing - Major Pathway0.82
    mRNA Processing0.85
    mRNA Splicing0.82
    3Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61
    Processing of Intronless Pre-mRNAs0.61
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/15        Reactome Pathways for CPSF7 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CPSF7):
        mRNA surveillance pathway


    CPSF7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/840 Interacting proteins for CPSF7 (Q8N6841, 2, 3 ENSP000003454124) via UniProtKB, MINT, STRING, and/or I2D (see all 840)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT21O438092, 3, ENSP000003002914MINT-66942 MINT-7947479 I2D: score=5 STRING: ENSP00000300291
    DVL2O146412, 3, ENSP000000053404MINT-67272 I2D: score=5 STRING: ENSP00000005340
    GCC1Q96CN92, 3, ENSP000003188214MINT-67470 I2D: score=5 STRING: ENSP00000318821
    NCK2O436392, 3, ENSP000002331544MINT-68386 I2D: score=5 STRING: ENSP00000233154
    CLP1Q929892, 3, ENSP000003047044MINT-7945693 I2D: score=1 STRING: ENSP00000304704
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    CPSF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPSF7

    Search CenterWatch for drugs/clinical trials and news about CPSF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPSF7 gene (3 alternative transcripts): 
    NM_001136040.2  NM_001142565.1  NM_024811.3  

    Unigene Cluster for CPSF7:

    Cleavage and polyadenylation specific factor 7, 59kDa
    Hs.718984  [show with all ESTs]
    Unigene Representative Sequence: NM_024811
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000340437(uc001nrp.3) ENST00000394888(uc001nrq.3 uc001nrr.3)
    ENST00000439958 ENST00000494016 ENST00000448745 ENST00000537641 ENST00000477890
    ENST00000544669(uc001nrs.1 uc009ynp.2) ENST00000539952 ENST00000535222
    ENST00000544990 ENST00000544585 ENST00000413232 ENST00000537162 ENST00000543545
    ENST00000541963 ENST00000536548 ENST00000450000
    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF7 (see all 47):
    hsa-miR-3164 hsa-miR-361-5p hsa-miR-200a hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-141 hsa-miR-3150b-3p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ275970.1 AK022591.1 AK096343.1 AK294578.1 AK307190.1 AL512759.1 AL832546.1 AL832667.1 
    AL833332.1 BC018135.1 BX537888.1 

    24/33 DOTS entries (see all 33):

    DT.100796630  DT.101984226  DT.100796629  DT.443264  DT.100680766  DT.95287901  DT.40256331  DT.95264122 
    DT.100796639  DT.91763448  DT.91763449  DT.100796633  DT.120728908  DT.91662897  DT.91763443  DT.91792048 
    DT.95230513  DT.100722846  DT.102833336  DT.102833337  DT.120728916  DT.431613  DT.91678006  DT.100708438 

    24/354 AceView cDNA sequences (see all 354):

    BM766570 AI468890 BQ771821 BQ009491 AA326383 AI081189 AI439221 AA397844 
    BU185553 BM549516 BQ676963 BE220069 BI907258 NM_024811 AA576877 AU154723 
    AA279821 BM561596 AK096343 BM696229 AI567566 CA416895 BM770522 BF916879 

    GeneLoc Exon Structure

    5/28 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF7 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
    SP1:                                                                                      -           -     -           -     -                                 
    SP2:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP3:                                -     -     -     -     -     -     -     -           -           -     -     -     -     -                                 
    SP4:                                                        -     -     -     -           -           -     -     -     -     -                                 
    SP5:                                -     -     -     -     -     -     -     -           -           -           -     -     -                                 

    ExUns: 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
    SP1:                          -                       -     -     -     -                       -                                   -                     
    SP2:                          -                                                                 -                                   -                     
    SP3:                                                                                            -                                   -                     
    SP4:                                                                                            -                                   -                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CPSF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPSF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCCCACC
    CPSF7 Expression
    About this image


    See CPSF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPSF7

    SOURCE GeneReport for Unigene cluster: Hs.718984
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPSF7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpsf71 , 5 cleavage and polyadenylation specific factor 71, 5 93.49(n)1
    98.73(a)1
      19 (6.60 cM)5
    2690611  NM_172302.31  NP_758506.31 
     105252445 
    chicken
    (Gallus gallus)
    Aves CPSF71 cleavage and polyadenylation specific factor 7, 59kDa 78.11(n)
    86.78(a)
      426014  XM_423693.3  XP_423693.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67592 Transcribed sequence with weak similarity to protein more 73.33(n)    CF240377.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R04E5.86
    cfim-26
    Protein CFIM-2, isoform d
    4(a)
    27(a)
    possible ortholog
    1 ↔ 1
    X(8802051-8806111)
    IV(8926335-8930345)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSH496
    U2-snRNP associated splicing factor with similarit...
    9(a)
    1 → many
    XV(912822-913463)


    ENSEMBL Gene Tree for CPSF7 (if available)
    TreeFam Gene Tree for CPSF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPSF7 gene
    CPSF62  
    1 SIMAP similar gene for CPSF7 using alignment to 14 protein entries:     CPSF7_HUMAN (see all proteins):
    CPSF6

    CPSF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/459 SNPs in CPSF7 are shown (see all 459)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904271051,2
    --61169686(+) TTGTAA/GGTGAA 3 -- int10--------
    rs1495070041,2
    C--61169885(+) CTTAGA/GAGTTT 3 -- int10--------
    rs112306871,2
    C,F,H--61169974(+) TCTTAG/AGAGGC 3 -- int119Minor allele frequency- A:0.14NS EA NA WA CSA 1644
    rs1498406291,2
    C--61170003(+) CCATG-/TGTATC 3 -- int10--------
    rs1822124561,2
    --61170208(+) GACAGC/TGTCAT 3 -- ut310--------
    rs1871719821,2
    --61170269(+) ACAACA/GGGGGG 3 -- ut310--------
    rs1911916151,2
    --61170276(+) GGGGAC/TGGGAC 3 -- ut310--------
    rs1175654071,2
    C,F--61170392(+) TCTCCG/AGGTAA 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs1395603331,2
    C--61170442(+) TGTCA-/CCTTTT 3 -- ut310--------
    rs1808192901,2
    --61170645(+) GACTGA/GGGGCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CPSF7 (61170120 - 61197503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPSF7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897603CNV Loss21882294
    nsv520751CNV Gain19592680
    nsv832178CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CPSF7:    About MalaCards
    wiskott-aldrich syndrome    tuberculosis


    CPSF7 for disorders           About GeneDecksing


    Export disorders for CPSF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPSF7 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CPSF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. (PubMed id 8626397)1, 2 Rueegsegger U.... Keller W. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79869 HGNC: 30098 AceView: FLJ12529 Ensembl:ENSG00000149532 euGenes: HUgn79869
    ECgene: CPSF7 Kegg: 79869 H-InvDB: CPSF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPSF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPSF7 gene:
    Search GeneIP for patents involving CPSF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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