Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPSF6 Gene

Aliases for CPSF6 Gene

  • Cleavage And Polyadenylation Specific Factor 6, 68kDa 2 3
  • Cleavage And Polyadenylation Specificity Factor 68 KDa Subunit 3 4
  • Pre-MRNA Cleavage Factor Im 68 KDa Subunit 3 4
  • Cleavage Factor Im Complex 68 KDa Subunit 2 3
  • CPSF 68 KDa Subunit 3 4
  • Protein HPBRII-4/7 3 4
  • CFIM68 3 4
  • CFIM 3 6
  • Cleavage And Polyadenylation Specific Factor 6, 68kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 6 3
  • Pre-MRNA Cleavage Factor I, 68kD Subunit 3
  • Pre-MRNA Cleavage Factor Im (68kD) 3
  • HPBRII-4 3
  • HPBRII-7 3

External Ids for CPSF6 Gene

Previous GeneCards Identifiers for CPSF6 Gene

  • GC12M069604
  • GC12P069573
  • GC12P069350
  • GC12P067919
  • GC12P069633

Summaries for CPSF6 Gene

Entrez Gene Summary for CPSF6 Gene

  • The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPSF6 Gene

CPSF6 (Cleavage And Polyadenylation Specific Factor 6, 68kDa) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is CPSF7.

UniProtKB/Swiss-Prot for CPSF6 Gene

  • Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.

Gene Wiki entry for CPSF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF6 Gene

Genomics for CPSF6 Gene

Regulatory Elements for CPSF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPSF6 Gene

Start:
69,239,537 bp from pter
End:
69,274,358 bp from pter
Size:
34,822 bases
Orientation:
Plus strand

Genomic View for CPSF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF6 Gene

Proteins for CPSF6 Gene

  • Protein details for CPSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16630-CPSF6_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 6
    Protein Accession:
    Q16630
    Secondary Accessions:
    • A8K7K9
    • Q53ES1
    • Q9BSJ7
    • Q9BW18

    Protein attributes for CPSF6 Gene

    Size:
    551 amino acids
    Molecular mass:
    59210 Da
    Quaternary structure:
    • Component of the cleavage factor Im (CFIm) complex, composed at least of NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5, SFRS3, SFRS7, SNRNP70 and TRA2B/SFRS10.

    Three dimensional structures from OCA and Proteopedia for CPSF6 Gene

    Alternative splice isoforms for CPSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF6 Gene

Proteomics data for CPSF6 Gene at MOPED

Post-translational modifications for CPSF6 Gene

  • Ubiquitination at Lys79, Lys161, and Lys185
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF6 Gene

No data available for DME Specific Peptides for CPSF6 Gene

Domains for CPSF6 Gene

Gene Families for CPSF6 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CPSF6 Gene

Suggested Antigen Peptide Sequences for CPSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16630

UniProtKB/Swiss-Prot:

CPSF6_HUMAN :
  • Q16630
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM CPSF6/7 family.
genes like me logo Genes that share domains with CPSF6: view

Function for CPSF6 Gene

Molecular function for CPSF6 Gene

UniProtKB/Swiss-Prot Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.

Gene Ontology (GO) - Molecular Function for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 contributes_to RNA binding IDA 15169763
GO:0003729 mRNA binding IDA 21295486
GO:0005515 protein binding IPI 14561889
genes like me logo Genes that share ontologies with CPSF6: view

Phenotypes for CPSF6 Gene

GenomeRNAi human phenotypes for CPSF6:
genes like me logo Genes that share phenotypes with CPSF6: view

Animal Model Products

CRISPR Products

miRNA for CPSF6 Gene

miRTarBase miRNAs that target CPSF6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPSF6 Gene

Localization for CPSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF6 Gene

Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF6 Gene COMPARTMENTS Subcellular localization image for CPSF6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20695905
GO:0005654 nucleoplasm IDA --
GO:0005849 mRNA cleavage factor complex IDA 20695905
GO:0016020 membrane IDA 19946888
GO:0030529 ribonucleoprotein complex IDA 18809582
genes like me logo Genes that share ontologies with CPSF6: view

Pathways for CPSF6 Gene

genes like me logo Genes that share pathways with CPSF6: view

Pathways by source for CPSF6 Gene

Gene Ontology (GO) - Biological Process for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 20695905
GO:0006397 mRNA processing IDA 14690600
GO:0051262 protein tetramerization IDA 20695905
genes like me logo Genes that share ontologies with CPSF6: view

Transcripts for CPSF6 Gene

Unigene Clusters for CPSF6 Gene

Cleavage and polyadenylation specific factor 6, 68kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CPSF6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for CPSF6 Gene

GeneLoc Exon Structure for
CPSF6
ECgene alternative splicing isoforms for
CPSF6

Expression for CPSF6 Gene

mRNA expression in normal human tissues for CPSF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF6 Gene

SOURCE GeneReport for Unigene cluster for CPSF6 Gene Hs.369606

genes like me logo Genes that share expressions with CPSF6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF6 Gene

Orthologs for CPSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF6 35
  • 99.58 (n)
  • 100 (a)
CPSF6 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF6 35
  • 96.13 (n)
  • 99.82 (a)
CPSF6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF6 35
  • 92.96 (n)
  • 94.07 (a)
CPSF6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf6 35
  • 92.56 (n)
  • 99.64 (a)
Cpsf6 16
Cpsf6 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF6 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF6 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf6 35
  • 93.47 (n)
  • 99.82 (a)
chicken
(Gallus gallus)
Aves CPSF6 35
  • 84.74 (n)
  • 94.72 (a)
CPSF6 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF6 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7296 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17115 35
zebrafish
(Danio rerio)
Actinopterygii cpsf6 36
  • 83 (a)
OneToOne
Dr.28441 35
fruit fly
(Drosophila melanogaster)
Insecta CG7185 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfim-2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3009 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for CPSF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF6 Gene

ENSEMBL:
Gene Tree for CPSF6 (if available)
TreeFam:
Gene Tree for CPSF6 (if available)

Paralogs for CPSF6 Gene

Paralogs for CPSF6 Gene

Selected SIMAP similar genes for CPSF6 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CPSF6 Gene

genes like me logo Genes that share paralogs with CPSF6: view

Variants for CPSF6 Gene

Sequence variations from dbSNP and Humsavar for CPSF6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15859 -- 69,249,747(+) GTTGA(A/G)TGTTC intron-variant
rs317630 -- 69,244,067(-) aagca(A/G)gaaga intron-variant
rs317631 -- 69,241,696(-) GGAGT(C/T)CCTCA intron-variant
rs317646 -- 69,263,365(-) CACTT(C/T)ATGAA intron-variant
rs317647 -- 69,261,179(-) ACCAT(A/G)TCAAA intron-variant

Relevant External Links for CPSF6 Gene

HapMap Linkage Disequilibrium report
CPSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CPSF6 Gene

Disorders for CPSF6 Gene

Relevant External Links for CPSF6

Genetic Association Database (GAD)
CPSF6
genes like me logo Genes that share disorders with CPSF6: view

No data available for UniProtKB/Swiss-Prot for CPSF6 Gene

Publications for CPSF6 Gene

  1. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PMID: 9659921) Rueegsegger U. … Keller W. (Mol. Cell 1998) 2 3 4
  2. Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. (PMID: 15937220) Venkataraman K. … Gilmartin G.M. (Genes Dev. 2005) 3 23
  3. Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. (PMID: 17267687) Cardinale S. … Barabino S.M. (Mol. Biol. Cell 2007) 2 3
  4. Association of polyadenylation cleavage factor I with U1 snRNP. (PMID: 14561889) Awasthi S. … Alwine J.C. (RNA 2003) 3 4
  5. A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. (PMID: 14690600) Brown K.M. … Gilmartin G.M. (Mol. Cell 2003) 3 4

Products for CPSF6 Gene

Sources for CPSF6 Gene

Back to Top

Content