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CPSF6 Gene

protein-coding   GIFtS: 57
GCID: GC12P069633

Cleavage And Polyadenylation Specific Factor 6, 68kDa

(Previous names: cleavage and polyadenylation specific factor 6, 68kD subunit)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cleavage And Polyadenylation Specific Factor 6, 68kDa1 2     Cleavage And Polyadenylation Specific Factor 6, 68kD Subunit1
Cleavage Factor Im Complex 68 KDa Subunit1 2     HPBRII-42
Cleavage And Polyadenylation Specificity Factor 68 KDa Subunit2 3     HPBRII-72
Pre-MRNA Cleavage Factor Im 68 KDa Subunit2 3     Cleavage And Polyadenylation Specificity Factor Subunit 62
Protein HPBRII-4/72 3     Pre-MRNA Cleavage Factor I, 68kD Subunit2
CFIM682 3     Pre-MRNA Cleavage Factor Im (68kD)2
CPSF 68 KDa Subunit2 3     CFIm683
CFIM2 5     

External Ids:    HGNC: 138711   Entrez Gene: 110522   Ensembl: ENSG000001116057   OMIM: 6049795   UniProtKB: Q166303   

Export aliases for CPSF6 gene to outside databases

Previous GC identifers: GC12M069604 GC12P069573 GC12P069350 GC12P067919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPSF6 Gene:
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and
polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the
assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The
cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain
organization reminiscent of spliceosomal proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPSF6 Gene:
CPSF6 (cleavage and polyadenylation specific factor 6, 68kDa) is a protein-coding gene. GO annotations related to this gene include mRNA binding and RNA binding. An important paralog of this gene is CPSF7.

UniProtKB/Swiss-Prot: CPSF6_HUMAN, Q16630
Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing.
Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6
binds to cleavage and polyadenylation RNA substrates and promotes RNA looping

Gene Wiki entry for CPSF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPSF6 gene promoter:
         NF-1/L   NF-1   Elk-1   MAZR   AML1a   E47   HEN1   STAT3   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPSF6 promoter sequence
   Search Chromatin IP Primers for CPSF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPSF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

CPSF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069633:  view genomic region     (about GC identifiers)

Start:
69,633,317 bp from pter      End:
69,668,138 bp from pter
Size:
34,822 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CPSF6_HUMAN, Q16630 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 6  
Size: 551 amino acids; 59210 Da
Subunit: Component of the cleavage factor Im (CFIm) complex, composed at least of NUDT21/CPSF5 and CPSF6 or CPSF7.
Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is
clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5, SFRS3, SFRS7, SNRNP70 and
TRA2B/SFRS10
5 PDB 3D structures from and Proteopedia for CPSF6:
3P5T (3D)        3P6Y (3D)        3Q2S (3D)        3Q2T (3D)        4B4N (3D)    
Secondary accessions: A8K7K9 Q53ES1 Q9BSJ7 Q9BW18
Alternative splicing: 3 isoforms:  Q16630-1   Q16630-2   Q16630-3   

Explore the universe of human proteins at neXtProt for CPSF6: NX_Q16630

Explore proteomics data for CPSF6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79, Lys161, Lys185
  • Modification sites at PhosphoSitePlus

  • See CPSF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008938.2  
    ENSEMBL proteins: 
     ENSP00000391774   ENSP00000446670   ENSP00000391437   ENSP00000266679   ENSP00000450206  
    Reactome Protein details: Q16630

    CPSF6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPSF6

     
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    antibodies-online peptides for CPSF6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q16630

    ProtoNet protein and cluster: Q16630

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CPSF6_HUMAN, Q16630
    Similarity: Belongs to the RRM CPSF6/7 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with CPSF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPSF6_HUMAN, Q16630
    Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing.
    Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6
    binds to cleavage and polyadenylation RNA substrates and promotes RNA looping

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723contributes to RNA binding IDA15169763
    GO:0003729mRNA binding IDA--
    GO:0005515protein binding IPI14561889
         
    Find genes that share ontologies with CPSF6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPSF6:
     Decreased cell number  G0/1 arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPSF6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPSF6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPSF6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPSF6:
    hsa-mir-215-5p (MIRT024266), hsa-mir-92a-3p (MIRT049065), hsa-mir-192-5p (MIRT026674)

    Block miRNA regulation of human, mouse, rat CPSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPSF6 (see all 110):
    hsa-miR-548j hsa-miR-579 hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCPSF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPSF6
    Predesigned siRNA for gene silencing in human, mouse, rat CPSF6

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPSF6 (NM_007007)
    Sino Biological Human cDNA Clone for CPSF6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPSF6_HUMAN, Q16630: Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles,
    called paraspeckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005849mRNA cleavage factor complex IDA--
    GO:0030529ribonucleoprotein complex IDA18809582
    GO:0042382paraspeckles IDA9659921

    Find genes that share ontologies with CPSF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPSF6 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3mRNA surveillance pathway
    mRNA surveillance pathway
    4Disease
    Disease


    Find genes that share SuperPaths with CPSF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CPSF6
        Signaling by FGFR1 fusion mutants


    1 Kegg Pathway  (Kegg details for CPSF6):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPSF6
    Interactions:

        GeneGlobe Interaction Network for CPSF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CPSF6 (Q166301, 2, 3 ENSP000003917744) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHL12Q53G592, 3, ENSP000003562304MINT-67222 I2D: score=5 STRING: ENSP00000356230
    WWP2O003082, 3, ENSP000003482834MINT-67985 I2D: score=5 STRING: ENSP00000348283
    RELBQ012012, 3MINT-49005 I2D: score=2 
    NUDT21O438091, 2, 3, ENSP000003002914EBI-358410,EBI-355720 MINT-8414090 MINT-8413995 MINT-67690 MINT-8414037 MINT-8414025 I2D: score=5 STRING: ENSP00000300291
    WWP1Q9H0M01, 2, 3, ENSP000002654284EBI-358410,EBI-742157 MINT-66359 I2D: score=6 STRING: ENSP00000265428
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IMP--
    GO:0006397mRNA processing IDA14690600
    GO:0051262protein tetramerization IDA--

    Find genes that share ontologies with CPSF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPSF6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPSF6 gene: 
    NM_007007.2  

    Unigene Cluster for CPSF6:

    Cleavage and polyadenylation specific factor 6, 68kDa
    Hs.369606  [show with all ESTs]
    Unigene Representative Sequence: NM_007007
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435070(uc001sut.4 uc001suu.4 uc010stk.2) ENST00000550075
    ENST00000456847 ENST00000266679 ENST00000550987 ENST00000551516 ENST00000547486

    miRNA
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    Block miRNA regulation of human, mouse, rat CPSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPSF6 (see all 110):
    hsa-miR-548j hsa-miR-579 hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCPSF6 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPSF6
      QuantiTect SYBR Green Assays in human, mouse, rat CPSF6
      QuantiFast Probe-based Assays in human, mouse, rat CPSF6

    Additional mRNA sequence: 

    AK021534.1 AK021833.1 AK093765.1 AK098338.1 AK223568.1 AK292024.1 AK299928.1 BC000714.2 
    BC005000.1 X67337.1 

    18 DOTS entries:

    DT.100028557  DT.91770904  DT.70103416  DT.91981183  DT.97773721  DT.95126043  DT.121189687  DT.86805461 
    DT.100806125  DT.121189683  DT.121189715  DT.91770901  DT.91770902  DT.417884  DT.121189720  DT.91770909 
    DT.95126038  DT.95147508 

    Selected AceView cDNA sequences (see all 359):

    AI146408 AI299651 BX507935 BQ009963 CD643926 AA910841 BI822149 BM748651 
    BM758741 AI222395 BM742862 AV708633 BM790086 AA836052 CF141943 BM561323 
    BP368706 BM743362 BQ011544 AA354466 CF529411 AA341622 AI637585 BU735730 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPSF6 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                    -                 -                                                                                       
    SP2:                    -                 -                       -                                                               
    SP3:                                                              -                                                               
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CPSF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPSF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTATCT
    CPSF6 Expression
    About this image

    CPSF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPSF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369606
        Custom PCR Arrays for CPSF6
    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPSF6
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    QuantiFast Probe-based Assays in human, mouse, rat CPSF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPSF6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpsf61 , 5 cleavage and polyadenylation specific factor 61, 5 92.56(n)1
    99.64(a)1
      10 (65.41 cM)5
    4325081  NM_001013391.21  NP_001013409.11 
     1173446735 
    chicken
    (Gallus gallus)
    Aves CPSF61 cleavage and polyadenylation specific factor 6, 68kDa 84.74(n)
    94.72(a)
      417844  NM_001039271.1  NP_001034360.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPSF66
    cleavage and polyadenylation specific factor 6, 68...
    95(a)
    1 ↔ 1
    GL343256.1(1526494-1548578)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.72962 Xenopus laevis, Similar to cleavage and polyadenylation more 81.09(n)    BC042306.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.284412 Danio rerio clone RK113A4C08 cleavage and polyadenylation more 75.43(n)    AY398330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71856
    --
    40(a)
    1 → many
    3L(8303593-8308602)
    worm
    (Caenorhabditis elegans)
    Secernentea cfim-26
    Protein CFIM-2, isoform b
    32(a)
    1 → many
    IV(8926335-8930345) WBGene00008362


    ENSEMBL Gene Tree for CPSF6 (if available)
    TreeFam Gene Tree for CPSF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPSF6 gene
    CPSF72  
    1 SIMAP similar gene for CPSF6 using alignment to 5 protein entries:     CPSF6_HUMAN (see all proteins):
    CPSF7

    Find genes that share paralogs with CPSF6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CPSF6
    PGOHUM00000234236


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPSF6 (see all 696)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175654871,2
    C,F--69631390(+) GGCATC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1812703231,2
    --69631577(+) ATCCCC/TACCTC 1 -- us2k10--------
    rs765202611,2
    C--69631703(+) TCTCAC/TCTTTA 1 -- us2k10--------
    rs1436506211,2
    C--69631704(+) CTCACC/TTTTAA 1 -- us2k10--------
    rs3725721571,2
    C--69631913(+) AAAACC/TGACTG 1 -- us2k10--------
    rs1481793741,2
    --69632076(+) TATTTA/GCATAT 1 -- us2k10--------
    rs112900081,2
    C--69632202(+) GCATG-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1850012641,2
    --69632379(+) TGATTG/TCTGGC 1 -- us2k10--------
    rs1890104161,2
    --69632502(+) TGGCTG/TAATGT 1 -- us2k10--------
    rs1440476201,2
    C--69632527(+) ACCATA/GTGACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPSF6 (69633317 - 69668138 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CPSF6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPSF6
    DNA2.0 Custom Variant and Variant Library Synthesis for CPSF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604979    OMIM disorders: --


    Find genes that share disorders with CPSF6           About GenesLikeMe

    Genetic Association Database (GAD): CPSF6

    Export disorders for CPSF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPSF6 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CPSF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PubMed id 9659921)1, 2, 3 Rueegsegger U.... Keller W. (Mol. Cell 1998)
    2. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. (PubMed id 21295486)1, 2 Yang Q.... Doublie S. (Structure 2011)
    3. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (Genes Cells 2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. (PubMed id 17267687)1, 3 Cardinale S....Barabino S.M. (Mol. Biol. Cell 2007)
    6. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (J. Biol. Chem. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. (PubMed id 14690600)1, 2 Brown K.M. and Gilmartin G.M. (Mol. Cell 2003)
    10. Association of polyadenylation cleavage factor I with U1 snRNP. (PubMed id 14561889)1, 2 Awasthi S. and Alwine J.C. (RNA 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11052 HGNC: 13871 AceView: CPSF6 Ensembl:ENSG00000111605 euGenes: HUgn11052
    ECgene: CPSF6 Kegg: 11052 H-InvDB: CPSF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPSF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPSF6 gene:
    Search GeneIP for patents involving CPSF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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