Aliases for CPSF6 Gene
External Ids for CPSF6 Gene
Previous GeneCards Identifiers for CPSF6 Gene
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPSF6 Gene
CPSF6 (Cleavage And Polyadenylation Specific Factor 6, 68kDa) is a Protein Coding gene. Among its related pathways are Signaling by FGFR1 in disease and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPSF7.
UniProtKB/Swiss-Prot for CPSF6 Gene
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.