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Aliases for CPSF4L Gene

Aliases for CPSF4L Gene

  • Cleavage And Polyadenylation Specific Factor 4-Like 2 3 5

External Ids for CPSF4L Gene

Previous GeneCards Identifiers for CPSF4L Gene

  • GC17M068757
  • GC17M071244
  • GC17M066653

Summaries for CPSF4L Gene

GeneCards Summary for CPSF4L Gene

CPSF4L (Cleavage And Polyadenylation Specific Factor 4-Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4L Gene

Genomics for CPSF4L Gene

Regulatory Elements for CPSF4L Gene

Promoters for CPSF4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPSF4L on UCSC Golden Path with GeneCards custom track

Genomic Location for CPSF4L Gene

Chromosome:
17
Start:
73,242,343 bp from pter
End:
73,262,532 bp from pter
Size:
20,190 bases
Orientation:
Minus strand

Genomic View for CPSF4L Gene

Genes around CPSF4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF4L Gene

Proteins for CPSF4L Gene

  • Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMK7-CPS4L_HUMAN
    Recommended name:
    Putative cleavage and polyadenylation specificity factor subunit 4-like protein
    Protein Accession:
    A6NMK7
    Secondary Accessions:
    • A8MU95
    • B2RXI9

    Protein attributes for CPSF4L Gene

    Size:
    179 amino acids
    Molecular mass:
    20727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CPSF4L Gene

Proteomics data for CPSF4L Gene at MOPED

Post-translational modifications for CPSF4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPSF4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPSF4L Gene

Domains & Families for CPSF4L Gene

Protein Domains for CPSF4L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPSF4L Gene

Graphical View of Domain Structure for InterPro Entry

A6NMK7

UniProtKB/Swiss-Prot:

CPS4L_HUMAN :
  • Belongs to the CPSF4/YTH1 family.
  • Contains 5 C3H1-type zinc fingers.
Family:
  • Belongs to the CPSF4/YTH1 family.
Similarity:
  • Contains 5 C3H1-type zinc fingers.
genes like me logo Genes that share domains with CPSF4L: view

No data available for Gene Families for CPSF4L Gene

Function for CPSF4L Gene

Gene Ontology (GO) - Molecular Function for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with CPSF4L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPSF4L Gene

Localization for CPSF4L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF4L Gene COMPARTMENTS Subcellular localization image for CPSF4L gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPSF4L Gene

Pathways & Interactions for CPSF4L Gene

SuperPathways for CPSF4L Gene

No Data Available

Interacting Proteins for CPSF4L Gene

Gene Ontology (GO) - Biological Process for CPSF4L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPSF4L Gene

Drugs & Compounds for CPSF4L Gene

No Compound Related Data Available

Transcripts for CPSF4L Gene

mRNA/cDNA for CPSF4L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPSF4L Gene

Cleavage and polyadenylation specific factor 4-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4L Gene

No ASD Table

Relevant External Links for CPSF4L Gene

GeneLoc Exon Structure for
CPSF4L
ECgene alternative splicing isoforms for
CPSF4L

Expression for CPSF4L Gene

mRNA expression in normal human tissues for CPSF4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for CPSF4L Gene

This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPSF4L Gene



SOURCE GeneReport for Unigene cluster for CPSF4L Gene Hs.534707

genes like me logo Genes that share expression patterns with CPSF4L: view

Protein tissue co-expression partners for CPSF4L Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPSF4L Gene

Orthologs for CPSF4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPSF4L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF4L 35
  • 83.97 (n)
  • 79.62 (a)
mouse
(Mus musculus)
Mammalia Cpsf4l 35
  • 81.33 (n)
  • 75.9 (a)
Cpsf4l 16
Cpsf4l 36
  • 44 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF4L 35
  • 99.63 (n)
  • 100 (a)
CPSF4L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf4l 35
  • 82.53 (n)
  • 75.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF4L 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF4L 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF4L 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Clp 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpsf-4 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9063 36
  • 34 (a)
OneToMany
Species with no ortholog for CPSF4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPSF4L Gene

ENSEMBL:
Gene Tree for CPSF4L (if available)
TreeFam:
Gene Tree for CPSF4L (if available)

Paralogs for CPSF4L Gene

Paralogs for CPSF4L Gene

(1) SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CPSF4L Gene

genes like me logo Genes that share paralogs with CPSF4L: view

Variants for CPSF4L Gene

Sequence variations from dbSNP and Humsavar for CPSF4L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs904379 -- 73,250,752(+) CTGAA(G/T)AGTAG intron-variant
rs4569356 -- 73,252,510(+) TGGAT(C/T)GGATG intron-variant
rs4969025 -- 73,263,418(+) TAATG(C/T)GATGG upstream-variant-2KB
rs4969089 -- 73,259,618(+) GGCTG(A/G)GCTGA intron-variant
rs5821954 -- 73,250,984(+) GCACA(-/G)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF4L Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897
nsv2138 CNV Insertion 18451855
nsv908735 CNV Loss 21882294

Variation tolerance for CPSF4L Gene

Gene Damage Index Score: 0.66; 14.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF4L Gene

HapMap Linkage Disequilibrium report
CPSF4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF4L Gene

Disorders for CPSF4L Gene

Relevant External Links for CPSF4L

Genetic Association Database (GAD)
CPSF4L
Human Genome Epidemiology (HuGE) Navigator
CPSF4L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF4L

No disorders were found for CPSF4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF4L Gene

Publications for CPSF4L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CPSF4L Gene

Sources for CPSF4L Gene

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