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Aliases for CPSF4L Gene

Aliases for CPSF4L Gene

  • Cleavage And Polyadenylation Specific Factor 4 Like 2 3 5

External Ids for CPSF4L Gene

Previous GeneCards Identifiers for CPSF4L Gene

  • GC17M068757
  • GC17M071244
  • GC17M066653

Summaries for CPSF4L Gene

GeneCards Summary for CPSF4L Gene

CPSF4L (Cleavage And Polyadenylation Specific Factor 4 Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4L Gene

Genomics for CPSF4L Gene

Regulatory Elements for CPSF4L Gene

Enhancers for CPSF4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G073287 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17 -29.2 -29219 7.7 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 CDC42EP4 CPSF4L FAM104A C17orf80 GC17P073281 GC17M073288
GH17G073298 1.1 ENCODE dbSUPER 11.7 -36.0 -35960 0.8 HDAC1 KLF1 ETV1 EBF1 THRB RARA ZFHX2 GATA3 NCOR1 GATA2 C17orf80 CPSF4L FAM104A GC17M073288 GC17P073281
GH17G073277 1.5 Ensembl ENCODE dbSUPER 8.4 -16.4 -16415 2.3 FOXA2 ARID4B FEZF1 ZNF2 ZNF48 YY1 PAF1 SP5 MIER2 SMARCA4 CDC42EP4 FAM104A C17orf80 CPSF4L COG1 GC17P073281 PIR39589
GH17G073346 1 Ensembl ENCODE dbSUPER 12 -84.8 -84819 1.9 CTCF ZFHX2 ZIC2 EGR2 CPSF4L CDC42EP4 FAM104A C17orf80 GC17M073289 GC17P073336
GH17G073348 0.9 Ensembl ENCODE dbSUPER 12 -86.8 -86798 1.7 CTCF GLIS1 CDC42EP4 CPSF4L FAM104A C17orf80 SDK2 GC17P073336 GC17M073289
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPSF4L on UCSC Golden Path with GeneCards custom track

Genomic Location for CPSF4L Gene

73,242,343 bp from pter
73,262,532 bp from pter
20,190 bases
Minus strand

Genomic View for CPSF4L Gene

Genes around CPSF4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF4L Gene

Proteins for CPSF4L Gene

  • Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative cleavage and polyadenylation specificity factor subunit 4-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MU95
    • B2RXI9

    Protein attributes for CPSF4L Gene

    179 amino acids
    Molecular mass:
    20727 Da
    Quaternary structure:
    No Data Available
    • Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CPSF4L Gene

Post-translational modifications for CPSF4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPSF4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPSF4L Gene

Domains & Families for CPSF4L Gene

Protein Domains for CPSF4L Gene


Suggested Antigen Peptide Sequences for CPSF4L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CPSF4/YTH1 family.
  • Belongs to the CPSF4/YTH1 family.
genes like me logo Genes that share domains with CPSF4L: view

No data available for Gene Families for CPSF4L Gene

Function for CPSF4L Gene

Gene Ontology (GO) - Molecular Function for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004521 endoribonuclease activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPSF4L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPSF4L Gene

Localization for CPSF4L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPSF4L gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with CPSF4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPSF4L Gene

Pathways & Interactions for CPSF4L Gene

SuperPathways for CPSF4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IBA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
GO:0098789 pre-mRNA cleavage required for polyadenylation IBA --
genes like me logo Genes that share ontologies with CPSF4L: view

No data available for Pathways by source and SIGNOR curated interactions for CPSF4L Gene

Drugs & Compounds for CPSF4L Gene

No Compound Related Data Available

Transcripts for CPSF4L Gene

mRNA/cDNA for CPSF4L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPSF4L Gene

Cleavage and polyadenylation specific factor 4-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4L Gene

No ASD Table

Relevant External Links for CPSF4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPSF4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPSF4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for CPSF4L Gene

This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPSF4L Gene

Protein tissue co-expression partners for CPSF4L Gene

NURSA nuclear receptor signaling pathways regulating expression of CPSF4L Gene:


SOURCE GeneReport for Unigene cluster for CPSF4L Gene:

genes like me logo Genes that share expression patterns with CPSF4L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF4L Gene

Orthologs for CPSF4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPSF4L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPSF4L 34 35
  • 99.63 (n)
(Bos Taurus)
Mammalia CPSF4L 34
  • 83.97 (n)
(Rattus norvegicus)
Mammalia Cpsf4l 34
  • 82.53 (n)
(Mus musculus)
Mammalia Cpsf4l 34 16 35
  • 81.33 (n)
(Monodelphis domestica)
Mammalia CPSF4L 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CPSF4L 35
  • 42 (a)
(Gallus gallus)
Aves CPSF4L 35
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clp 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea cpsf-4 35
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9063 35
  • 34 (a)
Species where no ortholog for CPSF4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPSF4L Gene

Gene Tree for CPSF4L (if available)
Gene Tree for CPSF4L (if available)

Paralogs for CPSF4L Gene

Paralogs for CPSF4L Gene

(1) SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins: Pseudogenes for CPSF4L Gene

genes like me logo Genes that share paralogs with CPSF4L: view

Variants for CPSF4L Gene

Sequence variations from dbSNP and Humsavar for CPSF4L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000087812 -- 73,244,762(+) AGTGC(C/T)TAGTG intron-variant
rs1000147716 -- 73,245,599(+) TACAG(A/G)AAAGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000321260 -- 73,250,731(+) AAGGA(C/T)GTTAT intron-variant
rs1000413759 -- 73,251,225(+) GATGC(C/T)TTTAG intron-variant
rs1000483653 -- 73,256,475(+) CTGCA(A/G)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF4L Gene

Variant ID Type Subtype PubMed ID
esv3641216 CNV loss 21293372
nsv2138 CNV insertion 18451855
nsv833534 CNV loss 17160897

Variation tolerance for CPSF4L Gene

Gene Damage Index Score: 0.66; 14.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF4L Gene

Disorders for CPSF4L Gene

Relevant External Links for CPSF4L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPSF4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF4L Gene

Publications for CPSF4L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CPSF4L Gene

Sources for CPSF4L Gene

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