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Aliases for CPSF4L Gene

Aliases for CPSF4L Gene

  • Cleavage And Polyadenylation Specific Factor 4-Like 2 3

External Ids for CPSF4L Gene

Previous GeneCards Identifiers for CPSF4L Gene

  • GC17M068757
  • GC17M071244
  • GC17M066653

Summaries for CPSF4L Gene

GeneCards Summary for CPSF4L Gene

CPSF4L (Cleavage And Polyadenylation Specific Factor 4-Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4L Gene

Genomics for CPSF4L Gene

Regulatory Elements for CPSF4L Gene

Genomic Location for CPSF4L Gene

73,248,449 bp from pter
73,262,352 bp from pter
13,904 bases
Minus strand

Genomic View for CPSF4L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF4L Gene

Proteins for CPSF4L Gene

  • Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative cleavage and polyadenylation specificity factor subunit 4-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MU95
    • B2RXI9

    Protein attributes for CPSF4L Gene

    179 amino acids
    Molecular mass:
    20727 Da
    Quaternary structure:
    No Data Available
    • Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CPSF4L Gene

Proteomics data for CPSF4L Gene at MOPED

Post-translational modifications for CPSF4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPSF4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPSF4L Gene

Domains for CPSF4L Gene

Protein Domains for CPSF4L Gene


Suggested Antigen Peptide Sequences for CPSF4L Gene

Graphical View of Domain Structure for InterPro Entry



  • A6NMK7
  • Belongs to the CPSF4/YTH1 family.
  • Contains 5 C3H1-type zinc fingers.
genes like me logo Genes that share domains with CPSF4L: view

No data available for Gene Families for CPSF4L Gene

Function for CPSF4L Gene

Gene Ontology (GO) - Molecular Function for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPSF4L: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF4L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPSF4L Gene

Localization for CPSF4L Gene

Subcellular locations from

Jensen Localization Image for CPSF4L Gene COMPARTMENTS Subcellular localization image for CPSF4L gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPSF4L Gene

Pathways for CPSF4L Gene

SuperPathways for CPSF4L Gene

No Data Available

Interacting Proteins for CPSF4L Gene

Gene Ontology (GO) - Biological Process for CPSF4L Gene


No data available for Pathways by source for CPSF4L Gene

Transcripts for CPSF4L Gene

mRNA/cDNA for CPSF4L Gene

(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPSF4L Gene

Cleavage and polyadenylation specific factor 4-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF4L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4L Gene

No ASD Table

Relevant External Links for CPSF4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPSF4L Gene

mRNA expression in normal human tissues for CPSF4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene

This gene is overexpressed in Testis (4.4).

Protein differential expression in normal tissues for CPSF4L Gene

This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPSF4L Gene

SOURCE GeneReport for Unigene cluster for CPSF4L Gene Hs.534707

genes like me logo Genes that share expressions with CPSF4L: view

Expression partners for CPSF4L Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPSF4L Gene

Orthologs for CPSF4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPSF4L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPSF4L 35
  • 83.97 (n)
  • 79.62 (a)
(Mus musculus)
Mammalia Cpsf4l 35
  • 81.33 (n)
  • 75.9 (a)
Cpsf4l 16
Cpsf4l 36
  • 44 (a)
(Pan troglodytes)
Mammalia CPSF4L 35
  • 99.63 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpsf4l 35
  • 82.53 (n)
  • 75.9 (a)
(Monodelphis domestica)
Mammalia CPSF4L 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CPSF4L 36
  • 42 (a)
(Gallus gallus)
Aves CPSF4L 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clp 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea cpsf-4 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9063 36
  • 34 (a)
Species with no ortholog for CPSF4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPSF4L Gene

Gene Tree for CPSF4L (if available)
Gene Tree for CPSF4L (if available)

Paralogs for CPSF4L Gene

Paralogs for CPSF4L Gene

Selected SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins: Pseudogenes for CPSF4L Gene

genes like me logo Genes that share paralogs with CPSF4L: view

Variants for CPSF4L Gene

Sequence variations from dbSNP and Humsavar for CPSF4L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs904379 -- 73,250,752(+) CTGAA(G/T)AGTAG intron-variant
rs4338850 -- 73,254,135(+) CCTTA(A/T)TTCTG intron-variant
rs4341801 -- 73,252,440(+) GAATA(C/T)ACATT intron-variant
rs4341802 -- 73,254,134(+) GCCTT(A/T)TTTCT intron-variant
rs4422038 -- 73,252,509(+) CTGGA(G/T)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF4L Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897
nsv2138 CNV Insertion 18451855
nsv908735 CNV Loss 21882294

Relevant External Links for CPSF4L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF4L Gene

Disorders for CPSF4L Gene

Relevant External Links for CPSF4L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CPSF4L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CPSF4L Gene

Publications for CPSF4L Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CPSF4L Gene

Sources for CPSF4L Gene

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