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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CPSF4L Gene

protein-coding GIFtS: 36
GCID: GC17M071244

cleavage and polyadenylation specific factor 4-like

Search for CPSF4L
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cleavage And Polyadenylation Specific Factor 4-Like¹ ²
Putative Cleavage And Polyadenylation Specificity Factor Subunit 4-Like Protein²

External Ids:	HGNC: 33632¹	Entrez Gene: 642843²	Ensembl: ENSG00000187959⁷	UniProtKB: A6NMK7³

Export aliases for CPSF4L gene to outside databases

Previous GC identifers: GC17M068757 GC17M066653

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CPSF4L gene promoter:
Tal-1 MAZR Lmo2 Nkx2-5 E47 YY1 MZF-1 GATA-6 Zic3 RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CPSF4L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF4L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

CPSF4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF4L gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M071244: view genomic region (about GC identifiers)

Start:	71,244,588 bp from pter	End:	71,258,491 bp from pter
Size:	13,904 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CPS4L_HUMAN, A6NMK7 (See protein sequence)

Recommended Name: Putative cleavage and polyadenylation specificity factor subunit 4-like protein

Size: 179 amino acids; 20727 Da

Sequence caution: Sequence=AC087301; Type=Erroneous gene model prediction;

Secondary accessions: A8MU95 B2RXI9

Explore the universe of human proteins at neXtProt for CPSF4L: NX_A6NMK7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NMK7

CPSF4L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001123357.1

ENSEMBL proteins:

ENSP00000343900 ENSP00000380788

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CPSF4L for domains About GeneDecksing

1 InterPro domain/family:

IPR000571 Znf_CCCH

Graphical View of Domain Structure for InterPro Entry A6NMK7

ProtoNet protein and cluster: A6NMK7

UniProtKB/Swiss-Prot: CPS4L_HUMAN, A6NMK7

Similarity: Belongs to the CPSF4/YTH1 family

Similarity: Contains 5 C3H1-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

CPSF4L for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CPSF4L

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for CPSF4L (ENSP00000343900⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CPSF3	ENSP00000238112⁴	STRING: ENSP00000238112
WDR82	ENSP00000296490⁴	STRING: ENSP00000296490
SEC13	ENSP00000312122⁴	STRING: ENSP00000312122
TBL3	ENSP00000331815⁴	STRING: ENSP00000331815
PAPOLB	ENSP00000384700⁴	STRING: ENSP00000384700

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CPSF4L
Search CenterWatch for drugs/clinical trials and news about CPSF4L / CPS4L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for CPSF4L gene:

NM_001129885.1

Unigene Cluster for CPSF4L:

Cleavage and polyadenylation specific factor 4-like

Hs.534707 [show with all ESTs]

Unigene Representative Sequence: BC157870

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344935(uc010dfk.1) ENST00000397671

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Additional cDNA sequence: BC157870.1

1 DOTS entry:

DT.120946245

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CPSF4L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCCAGAAT

About this image

CPSF4L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See CPSF4L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.534707

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF4L gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CPSF4L⁶	Uncharacterized protein	29(a)	1 ↔ 1	18(9025148-9028136)
fruit fly (Drosophila melanogaster)	Insecta	Clp⁶	Clipper	33(a)	1 → many	2L(819964-821209)
worm (Caenorhabditis elegans)	Secernentea	cpsf-4⁶	Cleavage and Polyadenylation Specificity Factor fa...	29(a)	1 → many	IV(12092298-12093450)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATCPSF30⁶	cleavage and polyadenylation specificity factor CP...	7(a)	1 → many	1(10770813-10775402)
rice (Oryza sativa)	Liliopsida	-- --	ATCPSF30/CPSF30, putative, expressed zinc finger C-x8-C-x5-C-x3-H type family protein, ...	8(a) 1(a)	many ↔ many many ↔ many	6(28150362-28155786) 6(25917415-25925337)

ENSEMBL Gene Tree for CPSF4L (if available)
TreeFam Gene Tree for CPSF4L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CPSF4L gene

CPSF4² ZC3H3²

1 SIMAP similar gene for CPSF4L using alignment to 2 protein entries: CPS4L_HUMAN (see all proteins):

CPSF4

CPSF4L for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for CPSF4L
PGOHUM00000246161 PGOHUM00000246162

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191156535^1,2		--	71245790(+)	`CCCCCA/CTTTCC`	1	--	int¹		0	--	--	--	--
rs145018271^1,2		--	71245911(+)	`CCATCG/TACTGC`	1	--	int¹		0	--	--	--	--
rs183439200^1,2		--	71246011(+)	`TTTGAA/GTTAAT`	1	--	int¹		0	--	--	--	--
rs147597908^1,2		--	71246055(+)	`AGAGGA/GGCTGC`	1	--	int¹		0	--	--	--	--
rs140766369^1,2		--	71246129(+)	`GACTCA/GAGCTT`	1	--	int¹		0	--	--	--	--
rs186649807^1,2		--	71246143(+)	`GTTTTA/GTGTAC`	1	--	int¹		0	--	--	--	--
rs78653931^1,2		--	71246146(+)	`TTATGT/CACATT`	1	--	int¹		2		CSA WA	120
rs150145938^1,2		--	71246212(+)	`ATTTTG/TAGTAG`	1	--	int¹		0	--	--	--	--
rs138567790^1,2		--	71246221(+)	`AGCTCA/GTTCAC`	1	--	int¹		0	--	--	--	--
rs112790822^1,2	C,	--	71246230(+)	`ACTTAC/GAGGAT`	1	--	int¹		3		NA WA	240

HapMap Linkage Disequilibrium report for CPSF4L (71244588 - 71258491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CPSF4L: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CPSF4L for disorders About MalaCards

CPSF4L for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: CPSF4L (1 document)

Export disorders for CPSF4L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CPSF4L gene integrated from 9 sources:
(articles sorted by number of sources associating them with CPSF4L)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 642843	HGNC: 33632	Ensembl:ENSG00000187959	euGenes: HUgn642843	ECgene: CPSF4L
H-InvDB: CPSF4L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CPSF4L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CPSF4L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CPSF4L gene:
Search GeneIP for patents involving CPSF4L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CPSF4L gene at Home site.

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CPSF4L Gene

cleavage and polyadenylation specific factor 4-like

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CPSF4L Gene

cleavage and polyadenylation specific factor 4-like

Aliasesfor CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene

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for CPSF4L gene