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Aliases for CPSF4 Gene

Aliases for CPSF4 Gene

  • Cleavage And Polyadenylation Specific Factor 4, 30kDa 2 3
  • CPSF30 3 4 6
  • NEB1 3 4 6
  • Cleavage And Polyadenylation Specificity Factor 30 KDa Subunit 3 4
  • NS1 Effector Domain-Binding Protein 1 3 4
  • CPSF 30 KDa Subunit 3 4
  • No Arches Homolog 3 4
  • Neb-1 3 4
  • NAR 3 4
  • Cleavage And Polyadenylation Specific Factor 4, 30kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 4 3
  • Cleavage-Polyadenylation Specificity Factor, 30kD 3
  • No Arches-Like Zinc Finger Protein 3

External Ids for CPSF4 Gene

Previous GeneCards Identifiers for CPSF4 Gene

  • GC07P097571
  • GC07P098634
  • GC07P098647
  • GC07P098619
  • GC07P098682
  • GC07P098874
  • GC07P099036
  • GC07P093673

Summaries for CPSF4 Gene

Entrez Gene Summary for CPSF4 Gene

  • Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPSF4 Gene

CPSF4 (Cleavage And Polyadenylation Specific Factor 4, 30kDa) is a Protein Coding gene. Diseases associated with CPSF4 include influenza. Among its related pathways are Disease and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZC3H3.

UniProtKB/Swiss-Prot for CPSF4 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).

Gene Wiki entry for CPSF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4 Gene

Genomics for CPSF4 Gene

Regulatory Elements for CPSF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPSF4 Gene

Start:
99,438,922 bp from pter
End:
99,457,373 bp from pter
Size:
18,452 bases
Orientation:
Plus strand

Genomic View for CPSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF4 Gene

Proteins for CPSF4 Gene

  • Protein details for CPSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95639-CPSF4_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 4
    Protein Accession:
    O95639
    Secondary Accessions:
    • D6W5S8
    • Q6FGE6
    • Q86TF8
    • Q9BTW6

    Protein attributes for CPSF4 Gene

    Size:
    269 amino acids
    Molecular mass:
    30255 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. Association with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs.

    Three dimensional structures from OCA and Proteopedia for CPSF4 Gene

    Alternative splice isoforms for CPSF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF4 Gene

Proteomics data for CPSF4 Gene at MOPED

Post-translational modifications for CPSF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPSF4 Gene

No data available for DME Specific Peptides for CPSF4 Gene

Domains for CPSF4 Gene

Protein Domains for CPSF4 Gene

Suggested Antigen Peptide Sequences for CPSF4 Gene

Graphical View of Domain Structure for InterPro Entry

O95639

UniProtKB/Swiss-Prot:

CPSF4_HUMAN :
  • O95639
Family:
  • Belongs to the CPSF4/YTH1 family.
Similarity:
  • Contains 5 C3H1-type zinc fingers.
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with CPSF4: view

No data available for Gene Families for CPSF4 Gene

Function for CPSF4 Gene

Molecular function for CPSF4 Gene

UniProtKB/Swiss-Prot Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).

Gene Ontology (GO) - Molecular Function for CPSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with CPSF4: view

Animal Model Products

CRISPR Products

miRNA for CPSF4 Gene

miRTarBase miRNAs that target CPSF4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPSF4 Gene

Localization for CPSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF4 Gene COMPARTMENTS Subcellular localization image for CPSF4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CPSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 21102410
genes like me logo Genes that share ontologies with CPSF4: view

Pathways for CPSF4 Gene

genes like me logo Genes that share pathways with CPSF4: view

Pathways by source for CPSF4 Gene

Gene Ontology (GO) - Biological Process for CPSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0019048 modulation by virus of host morphology or physiology TAS --
GO:0019054 modulation by virus of host process TAS --
GO:0019058 viral life cycle TAS --
GO:0046778 modification by virus of host mRNA processing TAS --
genes like me logo Genes that share ontologies with CPSF4: view

Compounds for CPSF4 Gene

(1) Novoseek inferred chemical compound relationships for CPSF4 Gene

Compound -log(P) Hits PubMed IDs
adenylate 48.7 1
genes like me logo Genes that share compounds with CPSF4: view

Transcripts for CPSF4 Gene

Unigene Clusters for CPSF4 Gene

Cleavage and polyadenylation specific factor 4, 30kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - -

Relevant External Links for CPSF4 Gene

GeneLoc Exon Structure for
CPSF4
ECgene alternative splicing isoforms for
CPSF4

Expression for CPSF4 Gene

mRNA expression in normal human tissues for CPSF4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF4 Gene

SOURCE GeneReport for Unigene cluster for CPSF4 Gene Hs.489287

genes like me logo Genes that share expressions with CPSF4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF4 Gene

Orthologs for CPSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPSF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF4 35
  • 99.63 (n)
  • 99.63 (a)
CPSF4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF4 35
  • 91.36 (n)
  • 95.47 (a)
CPSF4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF4 35
  • 95.17 (n)
  • 98.88 (a)
CPSF4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf4 35
  • 89.57 (n)
  • 95.73 (a)
Cpsf4 16
Cpsf4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf4 35
  • 89.3 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves CPSF4 35
  • 83.68 (n)
  • 94.24 (a)
CPSF4 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF4 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25683 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf4 35
  • 77.94 (n)
  • 91.45 (a)
Str.3196 35
zebrafish
(Danio rerio)
Actinopterygii cpsf4 35
  • 72.99 (n)
  • 85.87 (a)
cpsf4 36
  • 81 (a)
OneToOne
nar 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013044 35
  • 59.48 (n)
  • 60.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clp 35
  • 60.97 (n)
  • 58.74 (a)
Clp 36
  • 52 (a)
OneToMany
Clp 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cpsf-4 35
  • 53.41 (n)
  • 51.74 (a)
cpsf-4 36
  • 44 (a)
OneToMany
F11A10.3 37
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTH1 36
  • 36 (a)
OneToMany
YTH1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3252 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9063 36
  • 50 (a)
OneToMany
Species with no ortholog for CPSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF4 Gene

ENSEMBL:
Gene Tree for CPSF4 (if available)
TreeFam:
Gene Tree for CPSF4 (if available)

Paralogs for CPSF4 Gene

Paralogs for CPSF4 Gene

Selected SIMAP similar genes for CPSF4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPSF4: view

Variants for CPSF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CPSF4 Gene

Variant ID Type Subtype PubMed ID
nsv831069 CNV Loss 17160897
nsv5864 CNV Insertion 18451855
dgv7396n71 CNV Loss 21882294
dgv7397n71 CNV Loss 21882294

Relevant External Links for CPSF4 Gene

HapMap Linkage Disequilibrium report
CPSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CPSF4 Gene

Disorders for CPSF4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CPSF4 Gene including...

Search for CPSF4 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CPSF4 Gene

Relevant External Links for CPSF4

Genetic Association Database (GAD)
CPSF4
Human Genome Epidemiology (HuGE) Navigator
CPSF4
genes like me logo Genes that share disorders with CPSF4: view

No data available for UniProtKB/Swiss-Prot for CPSF4 Gene

Publications for CPSF4 Gene

  1. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. (PMID: 9224719) Barabino S.M.L. … Keller W. (Genes Dev. 1997) 2 3 4
  2. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. (PMID: 9651582) Nemeroff M.E. … Krug R.M. (Mol. Cell 1998) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPSF4 Gene

Sources for CPSF4 Gene

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