CPSF4 Gene
protein-coding GIFtS: 61
GCID: GC07P099036
|
|
cleavage and polyadenylation specific factor 4, 30kDa(Previous names: cleavage and polyadenylation specific factor 4, 30kD subunit...)
| |
Aliases
for CPSF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cleavage And Polyadenylation Specific Factor 4, 30kDa1 2 | | NS1 Effector Domain-Binding Protein 12 3 | | CPSF301 2 3 5 | | Cleavage And Polyadenylation Specific Factor 4, 30kD Subunit1 | | NAR1 2 3 | | Cleavage And Polyadenylation Specificity Factor Subunit 42 | | NEB12 3 5 | | Cleavage-Polyadenylation Specificity Factor, 30kD2 | | Cleavage And Polyadenylation Specificity Factor 30 KDa Subunit2 3 | | Neb-13 | | No Arches Homolog2 3 | | No Arches-Like Zinc Finger Protein2 | | CPSF 30 KDa Subunit2 3 | | Neb-13 |
Export aliases for CPSF4 gene to outside databasesPrevious GC identifers: GC07P097571 GC07P098634 GC07P098647 GC07P098619 GC07P098682 GC07P098874 GC07P093673 |
Summaries
for CPSF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CPSF4:
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires itseffector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage andpolyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. Ininfluenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specificfactor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNAsubstrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectivelyinhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants thatencode different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role inpre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and otherfactors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)
Gene Wiki entry for CPSF4
|
Genomic Views
for CPSF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPSF4 gene promoter:
STAT1 Pax-6 Pax-2 STAT1beta Pax-2a LCR-F1 STAT1alpha E2F-1 E2F Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPSF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22CPSF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P099036: view genomic region
(about GC identifiers)
Start:
|
99,036,545 bp from pter |
End:
|
99,054,996 bp from pter |
Size:
|
18,452 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 98,396,337-98,414,768 |
|
Proteins
for CPSF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639 (See
protein sequence)Recommended Name: Cleavage and polyadenylation specificity factor subunit 4 Size: 269 amino acids; 30255 Da
Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2,CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. Association with influenza A virus NS1 blocks processing of pre-mRNAs,thereby preventing nuclear export of host cell mRNAs
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for CPSF4:2D9N (3D)
2RHK (3D)
Secondary accessions: D6W5S8 Q6FGE6 Q86TF8 Q9BTW6Alternative splicing: 3 isoforms: O95639-1 O95639-2 O95639-3 (May be due to a competing acceptor splice site. No experimental confirmation available)Explore the universe of human proteins at neXtProt for CPSF4: NX_O95639
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95639
CPSF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001075028.1 NP_006684.1
ENSEMBL proteins: ENSP00000395311 ENSP00000396060 ENSP00000292476 ENSP00000401496 ENSP00000402224 ENSP00000401150 ENSP00000392584 ENSP00000415188 Reactome Protein details: O95639
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CPSF4 for ontologies About GeneDecksing
CPSF4 Antibody Products:
Assay Products for CPSF4: |
Protein
Domains /
Families
for CPSF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPSF4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95639ProtoNet protein and cluster: O95639 2 Blocks protein families: IPB000571 Zn-finger IPB001878 C2HC-type zinc-finger signature
UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639Similarity: Belongs to the CPSF4/YTH1 familySimilarity: Contains 5 C3H1-type zinc fingersSimilarity: Contains 1 CCHC-type zinc finger |
Function
for CPSF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role inpre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and otherfactors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CPSF4 (NM_006693) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CPSF4 for ontologies About GeneDecksing
|
Pathways & Interactions
for CPSF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NS1 Mediated Effects on Host Pathways | | | 2 | Disease | | | 3 | mRNA surveillance pathway | | | 4 | Synthesis of PB1-F2 | | | 5 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CPSF4
5 
Reactome Pathways for CPSF4
2 
Kegg Pathways (Kegg details for CPSF4):
CPSF4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/574 Interacting proteins for CPSF4 (O956392, 3 ENSP000002924764) via UniProtKB, MINT, STRING, and/or I2D (see all 574)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006397 | mRNA processing |
IEA | -- | | GO:0019048 | virus-host interaction |
TAS | -- | | GO:0019054 | modulation by virus of host cellular process |
TAS | -- | | GO:0019058 | viral infectious cycle |
TAS | -- | | GO:0046778 | modification by virus of host mRNA processing |
TAS | -- |
CPSF4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CPSF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CPSF4 for compounds About GeneDecksing
 Browse Tocris compounds for CPSF4
1 Novoseek chemical compound relationship for CPSF4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenylate |
48.7 |
1 |
9738505 (1) |
Search CenterWatch for drugs/clinical trials and news about CPSF4
|
Transcripts
for CPSF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPSF4 gene (2 alternative transcripts): NM_001081559.1 NM_006693.2 Unigene Cluster for CPSF4: Cleavage and polyadenylation specific factor 4, 30kDa Hs.489287 [show with all ESTs]Unigene Representative Sequence: NM_00669312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000436336(uc003uqi.3 uc003uqj.3 uc003uqk.3) ENST00000451876
ENST00000292476(uc011kix.2) ENST00000430038 ENST00000441580 ENST00000412686
ENST00000484112 ENST00000452047 ENST00000471455 ENST00000440514 ENST00000465132
ENST00000469897
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CPSF4 (NM_006693) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF4 |
Additional cDNA sequence: AK301745.1 BC003101.1 BC050738.1 CR542161.1 U79569.1 24/30 DOTS entries (see all 30): DT.216452 DT.92433039 DT.121072376 DT.95193010 DT.100771424 DT.75103311 DT.121072144 DT.100833877 DT.102837310 DT.95227196 DT.97853591 DT.216450 DT.100795087 DT.40223044 DT.102837318 DT.121072251 DT.92433042 DT.92433043 DT.95072017 DT.95246387 DT.100697331 DT.100795083 DT.121072312 DT.121072335 24/270 AceView cDNA sequences (see all 270): BM762080 BM563440 BI758098 CA842941 CB305741 BM811629 BI912817 AA612820 AA744576 BM462856 BM787372 AA877821 BI254246 AW516904 BM672096 CR625041 CR613235 CA310599 BM045007 BM910686 BQ052016 BU943495 CF529942 BU783053
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | | | - | | - | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | | | - | | - | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | - | | | | - | | - | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CPSF4
|
Expression
for CPSF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPSF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGCCTGGC
About this image
See CPSF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPSF4
SOURCE GeneReport for Unigene cluster: Hs.489287
SABiosciences Custom PCR Arrays for CPSF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPSF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPSF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPSF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPSF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF4 |
Orthologs
for CPSF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPSF4 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CPSF41 |
cleavage and polyadenylation specific factor 4, 30kDa |
84.91(n)
95.47(a) |
|
416494 XM_414800.3 XP_414800.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CPSF46 |
-- |
93(a) |
1 ↔ 1 |
GL343725.1(245614-251528) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.256832 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.68(n) |
|
CA982684.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nar2 |
no arches |
78.07(n) |
|
30203 BC045289.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Clp1 , 3 |
mRNA cleavage endoribonuclease3
Clipper1 |
54(a)3
61.83(n)1
58.36(a)1 |
|
21D33
332591 NM_057808.21 NP_477156.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F11A10.33
cpsf-41 |
Zinc finger, C3HC4 type (RING finger)3
Protein CPSF-41 |
61(a)3
53.36(n)1
51.55(a)1 |
|
IV(12089647-12093586)3
1781511 NM_001027955.21 NP_001023126.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATCPSF306 |
cleavage and polyadenylation specificity factor CP... |
9(a) |
1 → many |
1(10770813-10775402) |
rice
(Oryza sativa) |
Liliopsida |
---- |
ATCPSF30/CPSF30, putative, expressedzinc finger C-x8-C-x5-C-x3-H type family protein, ... |
9(a)2(a) |
many ↔ manymany ↔ many |
6(28150362-28155786) 6(25917415-25925337) |
ENSEMBL Gene Tree for CPSF4 (if available)
TreeFam Gene Tree for CPSF4 (if available) |
Paralogs
for CPSF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPSF4 gene
- CPSF4L2 ZC3H32
1 SIMAP similar gene for CPSF4 using alignment to 7 protein entries: CPSF4_HUMAN (see all proteins):CPSF4L
CPSF4 for paralogs About GeneDecksing
|
Genomic Variants
for CPSF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPSF4 (99036545 - 99054996 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CPSF4
1 CNV: 4548 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CPSF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPSF4 for disorders About GeneDecksing
OMIM gene information: 603052
OMIM disorders: --
7  diseases for CPSF4: About MalaCardsinfluenza epidermolysis bullosa simplex epidermolysis bullosa benign essential hypertension
essential hypertension erythromelalgia hypertension
1 disease from the University of Copenhagen DISEASES database for CPSF4:Influenza Human Genome Epidemiology (HuGE) Navigator: CPSF4 (3 documents)
Export disorders for CPSF4 gene to outside databases
|
Publications
for CPSF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPSF4 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with CPSF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. (PubMed id 9651582)1, 2, 3 Nemeroff M.E.... Krug R.M. (1998)
- The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. (PubMed id 9224719)1, 2, 3 Barabino S.M.L....Keller W. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PubMed id 21102410)2 Laishram R.S. and Anderson R.A. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for CPSF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CPSF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CPSF4 gene
(According to HUGE)
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Specialized Databases showing CPSF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CPSF4 | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/cpsf4/ |
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| Patent Information for CPSF4 gene:
Search GeneIP for patents involving CPSF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CPSF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CPSF4 | | OriGene shRNA RFP for CPSF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPSF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPSF4 | | | OriGene Protein Over-expression Lysate for CPSF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPSF4 | | OriGene 3'-UTR Clone for CPSF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CPSF4 | | OriGene Custom Protein Services for CPSF4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPSF4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPSF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPSF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPSF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPSF4 |
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| | | | Search Tocris compounds for CPSF4 |
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 | | | CPSF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF4 |
|  |  |  | | | | ThermoFisher Antibodies for CPSF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF4 |
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