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CPSF4 Gene

protein-coding   GIFtS: 61
GCID: GC07P099036

Cleavage And Polyadenylation Specific Factor 4, 30kDa

(Previous names: cleavage and polyadenylation specific factor 4, 30kD subunit)
  See CPSF4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cleavage And Polyadenylation Specific Factor 4, 30kDa1 2     NS1 Effector Domain-Binding Protein 12 3
CPSF302 3 5     Cleavage And Polyadenylation Specific Factor 4, 30kD Subunit1
NEB12 3 5     Cleavage And Polyadenylation Specificity Factor Subunit 42
Cleavage And Polyadenylation Specificity Factor 30 KDa Subunit2 3     Cleavage-Polyadenylation Specificity Factor, 30kD2
No Arches Homolog2 3     neb-12
NAR2 3     No Arches-Like Zinc Finger Protein2
CPSF 30 KDa Subunit2 3     Neb-13

External Ids:    HGNC: 23271   Entrez Gene: 108982   Ensembl: ENSG000001609177   OMIM: 6030525   UniProtKB: O956393   

Export aliases for CPSF4 gene to outside databases

Previous GC identifers: GC07P097571 GC07P098634 GC07P098647 GC07P098619 GC07P098682 GC07P098874 GC07P093673


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPSF4 Gene:
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires
its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage
and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular
pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and
polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro
prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs.
Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple
alternatively spliced transcript variants that encode different isoforms have been described for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CPSF4 Gene:
CPSF4 (cleavage and polyadenylation specific factor 4, 30kDa) is a protein-coding gene. Diseases associated with CPSF4 include influenza. GO annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4L.

UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in
pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and
other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for
poly(U)

Gene Wiki entry for CPSF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPSF4 gene promoter:
         STAT1   Pax-6   Pax-2   STAT1beta   Pax-2a   LCR-F1   STAT1alpha   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPSF4 promoter sequence
   Search Chromatin IP Primers for CPSF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

CPSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099036:  view genomic region     (about GC identifiers)

Start:
99,036,545 bp from pter      End:
99,054,996 bp from pter
Size:
18,452 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,396,337-98,414,768     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 4  
Size: 269 amino acids; 30255 Da
Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1,
CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. Association with influenza A virus NS1 blocks processing
of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs
2 PDB 3D structures from and Proteopedia for CPSF4:
2D9N (3D)        2RHK (3D)    
Secondary accessions: D6W5S8 Q6FGE6 Q86TF8 Q9BTW6
Alternative splicing: 3 isoforms:  O95639-1   O95639-2   O95639-3   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPSF4: NX_O95639

Explore proteomics data for CPSF4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPSF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001075028.1  NP_006684.1  

    ENSEMBL proteins: 
     ENSP00000395311   ENSP00000396060   ENSP00000292476   ENSP00000401496   ENSP00000402224  
     ENSP00000401150   ENSP00000392584   ENSP00000415188  
    Reactome Protein details: O95639

    CPSF4 Human Recombinant Protein Products:

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    antibodies-online proteins for CPSF4 (7 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry O95639

    ProtoNet protein and cluster: O95639

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: CPSF4_HUMAN, O95639
    Similarity: Belongs to the CPSF4/YTH1 family
    Similarity: Contains 5 C3H1-type zinc fingers
    Similarity: Contains 1 CCHC-type zinc finger


    Find genes that share domains with CPSF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPSF4_HUMAN, O95639
    Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in
    pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and
    other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for
    poly(U)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with CPSF4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CPSF4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPSF4:
    hsa-mir-30a-5p (MIRT028627), hsa-mir-124-3p (MIRT023215), hsa-mir-615-3p (MIRT039647)

    Block miRNA regulation of human, mouse, rat CPSF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPSF4 (see all 19):
    hsa-miR-4291 hsa-let-7d hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-3662 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCPSF4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPSF4_HUMAN, O95639: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    extracellular2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion ----
    GO:0005847mRNA cleavage and polyadenylation specificity factor complex IDA--

    Find genes that share ontologies with CPSF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPSF4 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Influenza Infection0.80
    NS1 Mediated Effects on Host Pathways0.00
    Host Interactions with Influenza Factors0.00
    Inhibition of Host mRNA Processing and RNA Silencing0.00
    2mRNA Splicing - Major Pathway
    mRNA processing0.44
    3Influenza A
    Influenza A0.34
    4mRNA surveillance pathway
    mRNA surveillance pathway
    5Disease
    Disease


    Find genes that share SuperPaths with CPSF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPSF4
        mRNA processing

    1 Reactome Pathway for CPSF4
        Inhibition of Host mRNA Processing and RNA Silencing


    2 Kegg Pathways  (Kegg details for CPSF4):
        mRNA surveillance pathway
    Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPSF4
    Interactions:

        Search GeneGlobe Interaction Network for CPSF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CPSF4 (O956392, 3 ENSP000002924764) via UniProtKB, MINT, STRING, and/or I2D (see all 628)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3MINT-63618 I2D: score=4 
    SPTAN1Q138132, 3MINT-7945693 I2D: score=3 
    FIP1L1Q6UN152, 3, ENSP000003367524MINT-7945693 MINT-67825 I2D: score=5 STRING: ENSP00000336752
    CPSF3Q9UKF62, ENSP000002381124MINT-7945693 MINT-8286479 MINT-8089129 STRING: ENSP00000238112
    CDC73Q6P1J92, 3, ENSP000003564054MINT-7945693 I2D: score=1 STRING: ENSP00000356405
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0019048modulation by virus of host morphology or physiology TAS--
    GO:0019054modulation by virus of host process TAS--
    GO:0019058viral life cycle TAS--
    GO:0046778modification by virus of host mRNA processing TAS--

    Find genes that share ontologies with CPSF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPSF4

    1 Novoseek inferred chemical compound relationship for CPSF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 48.7 1 9738505 (1)



    Find genes that share compounds with CPSF4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPSF4 gene (2 alternative transcripts): 
    NM_001081559.1  NM_006693.2  

    Unigene Cluster for CPSF4:

    Cleavage and polyadenylation specific factor 4, 30kDa
    Hs.489287  [show with all ESTs]
    Unigene Representative Sequence: NM_006693
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436336(uc003uqi.3 uc003uqj.3 uc003uqk.3) ENST00000451876
    ENST00000292476(uc011kix.2) ENST00000430038 ENST00000441580 ENST00000412686
    ENST00000484112 ENST00000452047 ENST00000471455 ENST00000440514 ENST00000482251
    ENST00000465132 ENST00000469897
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CPSF4 (see all 19):
    hsa-miR-4291 hsa-let-7d hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-3662 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCPSF4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CPSF4
      QuantiFast Probe-based Assays in human, mouse, rat CPSF4

    Additional mRNA sequence: 

    AK301745.1 BC003101.1 BC050738.1 CR542161.1 U79569.1 

    Selected DOTS entries (see all 30):

    DT.216452  DT.92433039  DT.121072376  DT.95193010  DT.100771424  DT.75103311  DT.121072144  DT.100833877 
    DT.102837310  DT.95227196  DT.97853591  DT.216450  DT.100795087  DT.40223044  DT.102837318  DT.121072251 
    DT.92433042  DT.92433043  DT.95072017  DT.95246387  DT.100697331  DT.100795083  DT.121072312  DT.121072335 

    Selected AceView cDNA sequences (see all 270):

    CR625041 BQ051981 BE388179 BE206082 BM691871 BE733054 BI830602 CA842941 
    BM811629 BM924655 BM910686 BM763844 BQ052009 AI024423 AI468659 AI857546 
    BI911203 AA804806 BI770074 BM469109 AA744576 BQ269021 CA310599 CR622877 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d
    SP1:                    -     -     -     -           -                             -     -           -                 -     -                           
    SP2:                    -     -     -     -           -                             -     -           -     -           -     -                           
    SP3:                    -     -     -     -           -                             -     -           -     -           -     -                           
    SP4:                                      -           -                             -     -           -     -           -     -                           
    SP5:                                      -           -                             -     -           -     -                                             


    ECgene alternative splicing isoforms for CPSF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCCTGGC
    CPSF4 Expression
    About this image

    CPSF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPSF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489287
        Custom PCR Arrays for CPSF4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPSF4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpsf41 , 5 cleavage and polyadenylation specific factor 41, 5 89.57(n)1
    95.73(a)1
      5 (85.08 cM)5
    541881  NM_178576.21  NP_848671.11 
     1451672135 
    chicken
    (Gallus gallus)
    Aves CPSF41 cleavage and polyadenylation specific factor 4, 30kDa 83.68(n)
    94.24(a)
      416494  NM_001277551.1  NP_001264480.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPSF46
    cleavage and polyadenylation specific factor 4, 30...
    82(a)
    1 ↔ 1
    GL343725.1(245187-255790)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256832 Xenopus laevis transcribed sequence with moderate similarity more 78.68(n)    CA982684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nar2 no arches 78.07(n)   30203  BC045289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clp1 , 3 mRNA cleavage endoribonuclease3
    Clipper1
    54(a)3
    60.97(n)1
    58.74(a)1
      21D33
    332591  NM_057808.21  NP_477156.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F11A10.33
    cpsf-41
    Zinc finger, C3HC4 type (RING finger)3
    cpsf-41
    61(a)3
    53.41(n)1
    51.74(a)1
      IV(12089647-12093586)3
    1781511  NM_001027955.31  NP_001023126.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YTH1(YPR107C)4 Essential RNA-binding component of cleavage and polyadenylation more   --   16(742064-741438) 856222  NP_015432.1 


    ENSEMBL Gene Tree for CPSF4 (if available)
    TreeFam Gene Tree for CPSF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPSF4 gene
    CPSF4L2  ZC3H32  
    1 SIMAP similar gene for CPSF4 using alignment to 7 protein entries:     CPSF4_HUMAN (see all proteins):
    CPSF4L

    Find genes that share paralogs with CPSF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CPSF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5864CNV Insertion18451855
    dgv7397n71CNV Loss21882294
    dgv7396n71CNV Loss21882294
    nsv831069CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CPSF4
    DNA2.0 Custom Variant and Variant Library Synthesis for CPSF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603052    OMIM disorders: --

    1 disease for CPSF4:    
    About MalaCards
    influenza

    3 diseases from the University of Copenhagen DISEASES database for CPSF4:
    Mucoepidermoid carcinoma     Progressive myoclonus epilepsy     Influenza

    Find genes that share disorders with CPSF4           About GenesLikeMe

    Genetic Association Database (GAD): CPSF4
    Human Genome Epidemiology (HuGE) Navigator: CPSF4 (3 documents)

    Export disorders for CPSF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPSF4 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CPSF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. (PubMed id 9651582)1, 2, 3 Nemeroff M.E.... Krug R.M. (Mol. Cell 1998)
    2. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. (PubMed id 9224719)1, 2, 3 Barabino S.M.L....Keller W. (Genes Dev. 1997)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (EMBO J. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length. (PubMed id 21822216)1 Sagawa F....Wilusz J. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10898 HGNC: 2327 AceView: CPSF4 Ensembl:ENSG00000160917 euGenes: HUgn10898
    ECgene: CPSF4 Kegg: 10898 H-InvDB: CPSF4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CPSF4 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cpsf4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPSF4 gene:
    Search GeneIP for patents involving CPSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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