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Aliases for CPSF3L Gene

Aliases for CPSF3L Gene

  • Cleavage And Polyadenylation Specific Factor 3-Like 2 3
  • INTS11 3 4 6
  • RC68 3 4 6
  • Cleavage And Polyadenylation-Specific Factor 3-Like Protein 3 4
  • Protein Related To CPSF Subunits Of 68 KDa 3 4
  • Integrator Complex Subunit 11 2 3
  • CPSF3-Like Protein 3 4
  • INT11 3 4
  • RC-68 3 4
  • Related To CPSF Subunits 68 KDa 3
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • CPSF73L 3

External Ids for CPSF3L Gene

Previous GeneCards Identifiers for CPSF3L Gene

  • GC01M001290
  • GC01M001236
  • GC01M000518
  • GC01M001249

Summaries for CPSF3L Gene

Entrez Gene Summary for CPSF3L Gene

  • The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF3L Gene

CPSF3L (Cleavage And Polyadenylation Specific Factor 3-Like) is a Protein Coding gene. Diseases associated with CPSF3L include meningococcal meningitis and anal fistula. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CPSF3.

UniProtKB/Swiss-Prot for CPSF3L Gene

  • Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Gene Wiki entry for CPSF3L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF3L Gene

Genomics for CPSF3L Gene

Regulatory Elements for CPSF3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPSF3L Gene

Start:
1,311,585 bp from pter
End:
1,324,691 bp from pter
Size:
13,107 bases
Orientation:
Minus strand

Genomic View for CPSF3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF3L Gene

Proteins for CPSF3L Gene

  • Protein details for CPSF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA45-INT11_HUMAN
    Recommended name:
    Integrator complex subunit 11
    Protein Accession:
    Q5TA45
    Secondary Accessions:
    • A8K5S2
    • B3KPR3
    • B4DM87
    • G3V1S5
    • Q5TA46
    • Q5TA48
    • Q5TA52
    • Q5TA53
    • Q5TA54
    • Q7L3D7
    • Q96HY1
    • Q9BW36
    • Q9H0F9
    • Q9H8R5
    • Q9HAA6
    • Q9NWX9

    Protein attributes for CPSF3L Gene

    Size:
    600 amino acids
    Molecular mass:
    67663 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=BAA91246.1; Type=Frameshift; Positions=587; Evidence={ECO:0000305}; Sequence=BAB14541.1; Type=Frameshift; Positions=248; Evidence={ECO:0000305}; Sequence=CAI23174.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23176.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23177.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23179.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CPSF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF3L Gene

Proteomics data for CPSF3L Gene at MOPED

Post-translational modifications for CPSF3L Gene

  • Ubiquitination at Lys280, Lys289, Lys462, Lys486, and Lys500
  • Modification sites at PhosphoSitePlus

Domains for CPSF3L Gene

Protein Domains for CPSF3L Gene

Graphical View of Domain Structure for InterPro Entry

Q5TA45

UniProtKB/Swiss-Prot:

INT11_HUMAN :
  • Q5TA45
Domain:
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
genes like me logo Genes that share domains with CPSF3L: view

No data available for Gene Families for CPSF3L Gene

Function for CPSF3L Gene

Molecular function for CPSF3L Gene

UniProtKB/Swiss-Prot Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Enzyme Numbers (IUBMB) for CPSF3L Gene

Gene Ontology (GO) - Molecular Function for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPSF3L: view

Phenotypes for CPSF3L Gene

genes like me logo Genes that share phenotypes with CPSF3L: view

Animal Model Products

CRISPR Products

miRNA for CPSF3L Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF3L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CPSF3L Gene

Localization for CPSF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF3L Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF3L Gene COMPARTMENTS Subcellular localization image for CPSF3L gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0032039 integrator complex IDA 16239144
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with CPSF3L: view

Pathways for CPSF3L Gene

SuperPathways for CPSF3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with CPSF3L: view

No data available for Pathways by source for CPSF3L Gene

Transcripts for CPSF3L Gene

Unigene Clusters for CPSF3L Gene

Cleavage and polyadenylation specific factor 3-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF3L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24: - - - - - - - -
SP25: - - - - - - -
SP26: - - - - - - - - - - - - - -
SP27: - - - - - - -
SP28: -
SP29: - - - - - -
SP30: - - - - -
SP31: - - - - - - -
SP32: -
SP33:
SP34:
SP35: - - - - - - - - - - - - - - - - - - - -
SP36:

ExUns: 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - -
SP18: -
SP19:
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32: - - - -
SP33: -
SP34:
SP35:
SP36:

ExUns: 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:

Relevant External Links for CPSF3L Gene

GeneLoc Exon Structure for
CPSF3L
ECgene alternative splicing isoforms for
CPSF3L

Expression for CPSF3L Gene

mRNA expression in normal human tissues for CPSF3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF3L Gene

SOURCE GeneReport for Unigene cluster for CPSF3L Gene Hs.6449

genes like me logo Genes that share expressions with CPSF3L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF3L Gene

Orthologs for CPSF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF3L 35
  • 96.05 (n)
  • 95.5 (a)
cow
(Bos Taurus)
Mammalia CPSF3L 35
  • 90.64 (n)
  • 97.16 (a)
CPSF3L 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF3L 35
  • 90.28 (n)
  • 97.5 (a)
CPSF3L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf3l 35
  • 87.11 (n)
  • 97.17 (a)
Cpsf3l 16
Cpsf3l 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF3L 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF3L 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf3l 35
  • 87.28 (n)
  • 97 (a)
chicken
(Gallus gallus)
Aves CPSF3L 35
  • 78.67 (n)
  • 92 (a)
CPSF3L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF3L 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9205 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf3l 35
  • 75.94 (n)
  • 89.5 (a)
Str.7162 35
zebrafish
(Danio rerio)
Actinopterygii cpsf3l 35
  • 77.07 (n)
  • 84.4 (a)
cpsf3l 36
  • 80 (a)
OneToOne
Dr.20157 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009923 35
  • 66.95 (n)
  • 69.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS11 35
  • 68.19 (n)
  • 68.75 (a)
IntS11 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10B5.8 35
  • 57.54 (n)
  • 61.68 (a)
F10B5.8 36
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSH1 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF73-II 35
  • 52.32 (n)
  • 47.17 (a)
rice
(Oryza sativa)
Liliopsida Os.27823 35
Os09g0397900 35
  • 57.28 (n)
  • 54.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4823 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for CPSF3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF3L Gene

ENSEMBL:
Gene Tree for CPSF3L (if available)
TreeFam:
Gene Tree for CPSF3L (if available)

Paralogs for CPSF3L Gene

Paralogs for CPSF3L Gene

genes like me logo Genes that share paralogs with CPSF3L: view

Variants for CPSF3L Gene

Sequence variations from dbSNP and Humsavar for CPSF3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1810745 -- 1,322,213(+) GAGGC(A/G)TGGGG intron-variant
rs1886772 -- 1,319,063(-) TGCAC(C/T)GGCTT intron-variant
rs1886773 -- 1,319,056(-) GCTTA(C/T)GAACC intron-variant
rs2296473 -- 1,314,848(-) GTCCA(C/T)GAGAC reference, synonymous-codon, nc-transcript-variant
rs4970432 -- 1,318,756(+) ATATA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF3L Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
nsv870963 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv35n71 CNV Loss 21882294
dgv36n71 CNV Loss 21882294
dgv37n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
dgv39n71 CNV Loss 21882294

Relevant External Links for CPSF3L Gene

HapMap Linkage Disequilibrium report
CPSF3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF3L Gene

Disorders for CPSF3L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CPSF3L Gene including...

Search for CPSF3L Gene in MalaCards »

(4) Novoseek inferred disease relationships for CPSF3L Gene

Disease -log(P) Hits PubMed IDs
complex partial seizures 46.2 2
stenoses 25.9 1
abscess 23.8 1
fistula 21 3

Relevant External Links for CPSF3L

Genetic Association Database (GAD)
CPSF3L
Human Genome Epidemiology (HuGE) Navigator
CPSF3L
genes like me logo Genes that share disorders with CPSF3L: view

No data available for UniProtKB/Swiss-Prot for CPSF3L Gene

Publications for CPSF3L Gene

  1. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PMID: 15684398) Dominski Z. … Marzluff W.F. (Mol. Cell. Biol. 2005) 2 3 4
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPSF3L Gene

Sources for CPSF3L Gene

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