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Aliases for CPSF3L Gene

Aliases for CPSF3L Gene

  • Cleavage And Polyadenylation Specific Factor 3-Like 2 3 5
  • Cleavage And Polyadenylation-Specific Factor 3-Like Protein 3 4
  • Protein Related To CPSF Subunits Of 68 KDa 3 4
  • CPSF3-Like Protein 3 4
  • INTS11 3 4
  • INT11 3 4
  • RC-68 3 4
  • RC68 3 4
  • Related To CPSF Subunits 68 KDa 3
  • Integrator Complex Subunit 11 2
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • CPSF73L 3

External Ids for CPSF3L Gene

Previous GeneCards Identifiers for CPSF3L Gene

  • GC01M001290
  • GC01M001236
  • GC01M000518
  • GC01M001249

Summaries for CPSF3L Gene

Entrez Gene Summary for CPSF3L Gene

  • The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF3L Gene

CPSF3L (Cleavage And Polyadenylation Specific Factor 3-Like) is a Protein Coding gene. Diseases associated with CPSF3L include meningococcal meningitis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CPSF3.

UniProtKB/Swiss-Prot for CPSF3L Gene

  • Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Gene Wiki entry for CPSF3L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF3L Gene

Genomics for CPSF3L Gene

Regulatory Elements for CPSF3L Gene

Genomic Location for CPSF3L Gene

Chromosome:
1
Start:
1,311,585 bp from pter
End:
1,324,691 bp from pter
Size:
13,107 bases
Orientation:
Minus strand

Genomic View for CPSF3L Gene

Genes around CPSF3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF3L Gene

Proteins for CPSF3L Gene

  • Protein details for CPSF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA45-INT11_HUMAN
    Recommended name:
    Integrator complex subunit 11
    Protein Accession:
    Q5TA45
    Secondary Accessions:
    • A8K5S2
    • B3KPR3
    • B4DM87
    • G3V1S5
    • Q5TA46
    • Q5TA48
    • Q5TA52
    • Q5TA53
    • Q5TA54
    • Q7L3D7
    • Q96HY1
    • Q9BW36
    • Q9H0F9
    • Q9H8R5
    • Q9HAA6
    • Q9NWX9

    Protein attributes for CPSF3L Gene

    Size:
    600 amino acids
    Molecular mass:
    67663 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=BAA91246.1; Type=Frameshift; Positions=587; Evidence={ECO:0000305}; Sequence=BAB14541.1; Type=Frameshift; Positions=248; Evidence={ECO:0000305}; Sequence=CAI23174.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23176.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23177.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23179.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CPSF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF3L Gene

Proteomics data for CPSF3L Gene at MOPED

Post-translational modifications for CPSF3L Gene

  • Ubiquitination at Lys 280, Lys 289, Lys 462, Lys 486, and Lys 500
  • Modification sites at PhosphoSitePlus

Domains & Families for CPSF3L Gene

Protein Domains for CPSF3L Gene

Graphical View of Domain Structure for InterPro Entry

Q5TA45

UniProtKB/Swiss-Prot:

INT11_HUMAN :
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
Domain:
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
genes like me logo Genes that share domains with CPSF3L: view

No data available for Gene Families for CPSF3L Gene

Function for CPSF3L Gene

Molecular function for CPSF3L Gene

UniProtKB/Swiss-Prot Function:
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Enzyme Numbers (IUBMB) for CPSF3L Gene

Gene Ontology (GO) - Molecular Function for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
genes like me logo Genes that share ontologies with CPSF3L: view
genes like me logo Genes that share phenotypes with CPSF3L: view

Animal Model Products

miRNA for CPSF3L Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF3L Gene

Localization for CPSF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF3L Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF3L Gene COMPARTMENTS Subcellular localization image for CPSF3L gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CPSF3L: view

Pathways & Interactions for CPSF3L Gene

genes like me logo Genes that share pathways with CPSF3L: view

Pathways by source for CPSF3L Gene

2 Reactome pathways for CPSF3L Gene

Gene Ontology (GO) - Biological Process for CPSF3L Gene

None

No data available for SIGNOR curated interactions for CPSF3L Gene

Drugs & Compounds for CPSF3L Gene

No Compound Related Data Available

Transcripts for CPSF3L Gene

Unigene Clusters for CPSF3L Gene

Cleavage and polyadenylation specific factor 3-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24: - - - - - - - -
SP25: - - - - - - -
SP26: - - - - - - - - - - - - - -
SP27: - - - - - - -
SP28: -
SP29: - - - - - -
SP30: - - - - -
SP31: - - - - - - -
SP32: -
SP33:
SP34:
SP35: - - - - - - - - - - - - - - - - - - - -
SP36:

ExUns: 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - -
SP18: -
SP19:
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32: - - - -
SP33: -
SP34:
SP35:
SP36:

ExUns: 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:

Relevant External Links for CPSF3L Gene

GeneLoc Exon Structure for
CPSF3L
ECgene alternative splicing isoforms for
CPSF3L

Expression for CPSF3L Gene

mRNA expression in normal human tissues for CPSF3L Gene

Protein differential expression in normal tissues from HIPED for CPSF3L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Liver, secretome (11.3), CD8 Tcells (7.9), and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF3L Gene



SOURCE GeneReport for Unigene cluster for CPSF3L Gene Hs.6449

genes like me logo Genes that share expression patterns with CPSF3L: view

Protein tissue co-expression partners for CPSF3L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF3L Gene

Orthologs for CPSF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF3L 35
  • 90.64 (n)
  • 97.16 (a)
CPSF3L 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF3L 35
  • 90.28 (n)
  • 97.5 (a)
CPSF3L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf3l 35
  • 87.11 (n)
  • 97.17 (a)
Cpsf3l 16
Cpsf3l 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF3L 35
  • 96.05 (n)
  • 95.5 (a)
rat
(Rattus norvegicus)
Mammalia Cpsf3l 35
  • 87.28 (n)
  • 97 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF3L 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF3L 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF3L 35
  • 78.67 (n)
  • 92 (a)
CPSF3L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF3L 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf3l 35
  • 75.94 (n)
  • 89.5 (a)
Str.7162 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9205 35
zebrafish
(Danio rerio)
Actinopterygii cpsf3l 35
  • 77.07 (n)
  • 84.4 (a)
Dr.20157 35
cpsf3l 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009923 35
  • 66.95 (n)
  • 69.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS11 35
  • 68.19 (n)
  • 68.75 (a)
IntS11 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10B5.8 35
  • 57.54 (n)
  • 61.68 (a)
F10B5.8 36
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSH1 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF73-II 35
  • 52.32 (n)
  • 47.17 (a)
rice
(Oryza sativa)
Liliopsida Os.27823 35
Os09g0397900 35
  • 57.28 (n)
  • 54.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4823 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for CPSF3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF3L Gene

ENSEMBL:
Gene Tree for CPSF3L (if available)
TreeFam:
Gene Tree for CPSF3L (if available)

Paralogs for CPSF3L Gene

Paralogs for CPSF3L Gene

genes like me logo Genes that share paralogs with CPSF3L: view

Variants for CPSF3L Gene

Sequence variations from dbSNP and Humsavar for CPSF3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1810745 -- 1,322,213(+) GAGGC(A/G)TGGGG intron-variant
rs1886772 -- 1,319,063(-) TGCAC(C/T)GGCTT intron-variant
rs1886773 -- 1,319,056(-) GCTTA(A/C/T)GAACC intron-variant
rs2296473 -- 1,314,848(-) GTCCA(C/T)GAGAC nc-transcript-variant, reference, synonymous-codon
rs4970432 -- 1,318,756(+) ATATA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF3L Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
nsv870963 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv35n71 CNV Loss 21882294
dgv36n71 CNV Loss 21882294
dgv37n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
dgv39n71 CNV Loss 21882294

Variation tolerance for CPSF3L Gene

Residual Variation Intolerance Score: 6.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF3L Gene

HapMap Linkage Disequilibrium report
CPSF3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF3L Gene

Disorders for CPSF3L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPSF3L Gene - From: GeneCards

Disorder Aliases PubMed IDs
meningococcal meningitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CPSF3L

Genetic Association Database (GAD)
CPSF3L
Human Genome Epidemiology (HuGE) Navigator
CPSF3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF3L
genes like me logo Genes that share disorders with CPSF3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPSF3L Gene

Publications for CPSF3L Gene

  1. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PMID: 15684398) Dominski Z. … Marzluff W.F. (Mol. Cell. Biol. 2005) 2 3 4 67
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for CPSF3L Gene

Sources for CPSF3L Gene

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