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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPSF3L Gene

protein-coding   GIFtS: 53
GCID: GC01M001236

cleavage and polyadenylation specific factor 3-like
 Explore 6 diseases affiliated with
CPSF3L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPSF3L    

Aliases
for CPSF3L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cleavage And Polyadenylation Specific Factor 3-Like1 2     CPSF3-Like Protein2 3
INTS111 2 3     FLJ205421
RC-681 2 3     Integrator Complex Subunit 112
CPSF73L1 2     Related To CPSF Subunits 68 KDa2
INT111 2     EC 3.1.27.-3
Cleavage And Polyadenylation-Specific Factor 3-Like Protein2 3     Int113
Protein Related To CPSF Subunits Of 68 KDa2 3     EC 3.1.278
RC682 3     

External Ids:    HGNC: 260521   Entrez Gene: 549732   Ensembl: ENSG000001270547   OMIM: 6113545   UniProtKB: Q5TA453   

Export aliases for CPSF3L gene to outside databases

Previous GC identifers: GC01M001290 GC01M000518


Summaries
for CPSF3L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPSF3L:
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680)
and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005
(PubMed 16239144)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45
Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates
the snRNAs 3' cleavage

Gene Wiki entry for CPSF3L


Genomic Views
for CPSF3L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPSF3L gene promoter:
         NRSF form 1   HNF-4alpha2   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPSF3L promoter sequence
   Search SABiosciences Chromatin IP Primers for CPSF3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CPSF3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF3L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001236:  view genomic region     (about GC identifiers)

Start:
 1,246,965 bp from pter      End:
 1,260,071 bp from pter
Size:
 13,107 bases      Orientation:
 minus strand

Proteins
for CPSF3L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45 (See protein sequence)
Recommended Name: Integrator complex subunit 11  
Size: 600 amino acids; 67663 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,
INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=BAA91246.1; Type=Frameshift; Positions=587; Sequence=BAB14541.1; Type=Frameshift;
Positions=248; Sequence=CAI23174.1; Type=Erroneous initiation; Sequence=CAI23176.1; Type=Erroneous initiation;
Sequence=CAI23177.1; Type=Erroneous initiation; Sequence=CAI23179.1; Type=Erroneous gene model prediction;
Sequence=CAI23180.1; Type=Erroneous gene model prediction; Sequence=CAI23181.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DM87 Q5TA46 Q5TA48 Q5TA52 Q5TA53 Q5TA54 Q7L3D7 Q96HY1 Q9BW36 Q9H0F9 Q9H8R5
Q9HAA6 Q9NWX9
Alternative splicing: 4 isoforms:  Q5TA45-1   Q5TA45-2   Q5TA45-3   Q5TA45-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPSF3L: NX_Q5TA45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5TA45

    • 4/23 DME Specific Peptides for CPSF3L (Q5TA45) (see all 23)
     SHFHLDH  DCGMHMG  FEFKHIK  RERDFLK 

    CPSF3L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243385.1  NP_001243389.1  NP_001243391.1  NP_001243392.1  NP_060341.2  

    ENSEMBL proteins: 
     ENSP00000413493   ENSP00000400548   ENSP00000464436   ENSP00000433930   ENSP00000404886  
     ENSP00000431214   ENSP00000392848   ENSP00000431952   ENSP00000432777   ENSP00000433264  
     ENSP00000431425   ENSP00000411233   ENSP00000435418   ENSP00000434790   ENSP00000404012  
     ENSP00000436743   ENSP00000432009   ENSP00000435772   ENSP00000433733   ENSP00000436824  
     ENSP00000434782   ENSP00000436396   ENSP00000445001   ENSP00000444672  

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    Uscn Proteins for CPSF3L

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    CPSF3L for ontologies           About GeneDecksing



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    Uscn Antibodies for CPSF3L
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    Uscn ELISAs and CLIAs for CPSF3L

    Protein Domains /
    Families
    for CPSF3L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPSF3L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011108 RMMBL
     IPR001279 Beta-lactamas-like
     IPR022712 Beta_Casp

    Graphical View of Domain Structure for InterPro Entry Q5TA45

    ProtoNet protein and cluster: Q5TA45

    1 Blocks protein family: IPB011108 RNA-metabolising metallo-beta-lactamase

    UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45
    Domain: The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)
    Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.
    INTS11 subfamily


    Function
    for CPSF3L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45
    Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates
    the snRNAs 3' cleavage

    Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--


    CPSF3L for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CPSF3L:
     Cell division defect  Decreased nuclei size in G2M  Increased S DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for CPSF3L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for CPSF3L (Q5TA452, 3 ENSP000004134934) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248208 I2D: score=2 
    CSNK2BP678702, 3MINT-8253198 I2D: score=2 
    PLK1P533502, 3MINT-8266854 I2D: score=2 
    TK1P041832, 3MINT-8273191 I2D: score=2 
    PLSCR1O151622, 3, ENSP000003454944MINT-67238 I2D: score=5 STRING: ENSP00000345494
    About this table

    Drugs & Compounds
    for CPSF3L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPSF3L
    Search CenterWatch for drugs/clinical trials and news about CPSF3L / INT11 

    Transcripts
    for CPSF3L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPSF3L gene (6 alternative transcripts): 
    NM_032179.1  NM_001256456.1  NM_001256460.1  NM_001256462.1  NM_001256463.1  NM_017871.5  

    Unigene Cluster for CPSF3L:

    Cleavage and polyadenylation specific factor 3-like
    Hs.6449  [show with all ESTs]
    Unigene Representative Sequence: BC047576
    18/48 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48):
    ENST00000470030 ENST00000435064(uc001aee.1 uc009vjz.1 uc001aeh.1)
    ENST00000497304 ENST00000323275(uc001aeg.1) ENST00000411962(uc001aei.1)
    ENST00000462432(uc009vjy.1) ENST00000478641 ENST00000421495(uc001aek.1)
    ENST00000458452(uc001aef.1 uc010nyj.1) ENST00000419704 ENST00000532772
    ENST00000450926 ENST00000527098 ENST00000485710 ENST00000461514 ENST00000525164
    ENST00000528879 ENST00000525769

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK000549.1 AK021939.1 AK022675.1 AK023356.1 AK027767.1 AK056652.1 AK058018.1 AK092190.1 
    AK291387.1 AK297350.1 AL136813.1 BC000675.2 BC007978.2 BC008041.2 BC013904.2 BC020199.1 
    BC042444.1 BC047576.1 CR533557.1 

    24/42 DOTS entries (see all 42):

    DT.100862238  DT.100862242  DT.100862225  DT.455178  DT.100862228  DT.101985336  DT.95164263  DT.100031157 
    DT.121344420  DT.121344485  DT.92447042  DT.100862224  DT.95164246  DT.100862232  DT.121344451  DT.95164283 
    DT.100031155  DT.100862243  DT.121344508  DT.100862241  DT.121344466  DT.121344551  DT.100771371  DT.100862239 

    24/451 AceView cDNA sequences (see all 451):

    BQ950953 AI860840 AI571441 BM849355 AK123641 BE560076 AA682276 W93340 
    BF902765 AW247906 CR614665 AI084871 BG154171 AI972167 AI473542 BQ020831 
    BG013990 BM819988 BF340101 CR592541 BM918755 BM818827 AI290413 BE513665 

    GeneLoc Exon Structure

    5/36 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3L (see all 36)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
    SP1:                                                                    -                 -     -     -                                         -               
    SP2:                          -     -     -     -                       -                 -     -     -                                         -               
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP4:                          -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
    SP1:                          -     -                 -                 -     -     -                                   -                                       
    SP2:                          -     -                 -                 -     -     -                                                                           
    SP3:                          -     -                 -                 -     -     -                                                                           
    SP4:  -     -     -     -     -     -                 -                 -     -     -                                   -                                       
    SP5:                                                                    -     -     -                                   -                                       

    ExUns: 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:  -                                       


    ECgene alternative splicing isoforms for CPSF3L

    Expression
    for CPSF3L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPSF3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACACACGCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CPSF3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPSF3L

    SOURCE GeneReport for Unigene cluster: Hs.6449
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    Orthologs
    for CPSF3L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPSF3L gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPSF3L1 cleavage and polyadenylation specific factor 3-like less 78.67(n)
    92(a)    		   419418  NM_001012836.1  NP_001012854.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CPSF3L6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343760.1(113771-135921)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.92052 Xenopus laevis transcribed sequence with weak similarity to protein spQ9UKF6 (H.sapiens) CPSC_HUMAN Cleavage and polyadenylation specificity factor, 73 kDa subunit (CPSF 73 kDa subunit) less 75.15(n)    BX844337.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.201572 Transcribed sequence with weak similarity to protein spQ9UKF6 (H.sapiens) CPSC_HUMAN Cleavage and polyadenylation specificity factor, 73 kDa subunit (CPSF 73 kDa subunit) less 80.47(n)    CK024903.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta IntS111 Integrator 11 68.19(n)
    68.75(a)    		   43506  NM_143464.3  NP_651721.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F10B5.81 Protein F10B5.8 57.54(n)
    61.68(a)    		   174310  NM_063305.5  NP_495706.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CPSF73-II1 cleavage and polyadenylation specificity factor subunit 3-II less 52.32(n)
    47.17(a)    		   814702  NM_126234.2  NP_178282.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.278232 Oryza sativa (japonica cultivar-group) cDNA cloneJ033033M06, full insert sequence less 73.39(n)    AK101306.1 


    ENSEMBL Gene Tree for CPSF3L (if available)
    TreeFam Gene Tree for CPSF3L (if available) 

    Paralogs
    for CPSF3L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPSF3L gene
    CPSF22  CPSF32  
    1 SIMAP similar gene for CPSF3L using alignment to 22 protein entries:     INT11_HUMAN (see all proteins):
    CPSF3

    CPSF3L for paralogs           About GeneDecksing



    Genomic Variants
    for CPSF3L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in CPSF3L are shown (see all 347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2003896561,2
    		--1246474(+) GAGAAA/GCTCCT 6 -- int10--------
    rs1123560491,2
    		C,--1246484(+) TGTCAT/CGTGCC 6 -- int12Minor allele frequency- C:0.07CSA WA 120
    rs780282481,2
    		C,F,--1246487(+) CATGTG/ACCCAG 6 -- int11Minor allele frequency- A:0.04WA 118
    rs1155403701,2
    		C,--1246488(+) ATGTGC/TCCAGT 6 -- int10--------
    rs2019602251,2
    		--1246494(+) CCAGTA/GACTAC 6 -- int10--------
    rs1135073851,2
    		--1246509(+) GCCGAG/AGCATG 6 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs1809862341,2
    		--1246599(+) AGCCCA/GTAGCC 6 -- int10--------
    rs1860271581,2
    		C,--1246675(+) GTCTTC/GCCCCA 6 -- int10--------
    rs1920980211,2
    		--1246831(+) TCACAA/GCTGCT 6 -- int1 ut310--------
    rs778487831,2
    		C,F,--1246907(+) ATGCCC/TGTCTC 6 -- ut31 int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CPSF3L (1246965 - 1260071 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CPSF3L
         3 CNVs: 0001 3275 30362

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    Disorders / Diseases
    for CPSF3L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPSF3L for disorders           About GeneDecksing

    OMIM gene information: 611354    OMIM disorders: --

    6 diseases for CPSF3L:    About MalaCards
    factor v and factor viii    trigonitis    meningitis    seizures
    crohn's disease    malaria

    4 Novoseek disease relationships for CPSF3L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    complex partial seizures 46.2 2 1734323 (1), 17608301 (1)
    stenoses 25.9 1 7790539 (1)
    abscess 23.8 1 11504291 (1)
    fistula 21 5 17629041 (1), 7720446 (1), 11504291 (1)

    Human Genome Epidemiology (HuGE) Navigator: CPSF3L (3 documents)

    Export disorders for CPSF3L gene to outside databases

    Publications
    for CPSF3L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPSF3L gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CPSF3L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PubMed id 15684398)1, 2, 3 Dominski Z.... Marzluff W.F. (2005)
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. snRNA 3' end formation requires heterodimeric associat ion of integrator subunits. (PubMed id 22252320)1 Albrecht T.R. and Wagner E.J. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for CPSF3L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CPSF3L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54973 HGNC: 26052 AceView: FLJ20542 Ensembl:ENSG00000127054 euGenes: HUgn54973
    ECgene: CPSF3L H-InvDB: CPSF3L

    Other Databases showing CPSF3L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPSF3L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPSF3L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPSF3L Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CPSF3L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPSF3L gene:
    Search GeneIP for patents involving CPSF3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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