CPSF3L Gene
protein-coding GIFtS: 53
GCID: GC01M001236
|
|
cleavage and polyadenylation specific factor 3-like
| |
Aliases
for CPSF3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cleavage And Polyadenylation Specific Factor 3-Like1 2 | | CPSF3-Like Protein2 3 | | INTS111 2 3 | | FLJ205421 | | RC-681 2 3 | | Integrator Complex Subunit 112 | | CPSF73L1 2 | | Related To CPSF Subunits 68 KDa2 | | INT111 2 | | EC 3.1.27.-3 | | Cleavage And Polyadenylation-Specific Factor 3-Like Protein2 3 | | Int113 | | Protein Related To CPSF Subunits Of 68 KDa2 3 | | EC 3.1.278 | | RC682 3 | | |
Export aliases for CPSF3L gene to outside databasesPrevious GC identifers: GC01M001290 GC01M000518 |
Summaries
for CPSF3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CPSF3L:
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase IIlarge subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680)and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005(PubMed 16239144)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediatesthe snRNAs 3' cleavage
Gene Wiki entry for CPSF3L
|
Genomic Views
for CPSF3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPSF3L gene promoter:
NRSF form 1 HNF-4alpha2 NRSF form 2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPSF3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33CPSF3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001236: view genomic region
(about GC identifiers)
Start:
|
1,246,965 bp from pter |
End:
|
1,260,071 bp from pter |
Size:
|
13,107 bases |
Orientation:
|
minus strand |
|
Proteins
for CPSF3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45 (See
protein sequence)Recommended Name: Integrator complex subunit 11 Size: 600 amino acids; 67663 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=BAA91246.1; Type=Frameshift; Positions=587; Sequence=BAB14541.1; Type=Frameshift;Positions=248; Sequence=CAI23174.1; Type=Erroneous initiation; Sequence=CAI23176.1; Type=Erroneous initiation;Sequence=CAI23177.1; Type=Erroneous initiation; Sequence=CAI23179.1; Type=Erroneous gene model prediction;Sequence=CAI23180.1; Type=Erroneous gene model prediction; Sequence=CAI23181.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DM87 Q5TA46 Q5TA48 Q5TA52 Q5TA53 Q5TA54 Q7L3D7 Q96HY1 Q9BW36 Q9H0F9 Q9H8R5Q9HAA6 Q9NWX9Alternative splicing: 4 isoforms: Q5TA45-1 Q5TA45-2 Q5TA45-3 Q5TA45-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CPSF3L: NX_Q5TA45
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TA45
4/23 DME Specific Peptides for CPSF3L (Q5TA45) (see all 23)
CPSF3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001243385.1 NP_001243389.1 NP_001243391.1 NP_001243392.1 NP_060341.2
ENSEMBL proteins: ENSP00000413493 ENSP00000400548 ENSP00000464436 ENSP00000433930 ENSP00000404886 ENSP00000431214 ENSP00000392848 ENSP00000431952 ENSP00000432777 ENSP00000433264 ENSP00000431425 ENSP00000411233 ENSP00000435418 ENSP00000434790 ENSP00000404012 ENSP00000436743 ENSP00000432009 ENSP00000435772 ENSP00000433733 ENSP00000436824 ENSP00000434782 ENSP00000436396 ENSP00000445001 ENSP00000444672
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CPSF3L for ontologies About GeneDecksing
CPSF3L Antibody Products:
Assay Products for CPSF3L: |
Protein
Domains /
Families
for CPSF3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPSF3L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TA45ProtoNet protein and cluster: Q5TA45 1 Blocks protein family: IPB011108 RNA-metabolising metallo-beta-lactamase
UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45Domain: The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.INTS11 subfamily |
Function
for CPSF3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: INT11_HUMAN, Q5TA45Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediatesthe snRNAs 3' cleavageEnzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CPSF3L (NM_017871) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF3L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF3L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
CPSF3L for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CPSF3L:
|
Pathways & Interactions
for CPSF3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for CPSF3L (Q5TA452, 3 ENSP000004134934) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
|
Drugs & Compounds
for CPSF3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPSF3L
Search CenterWatch for drugs/clinical trials and news about CPSF3L / INT11
|
Transcripts
for CPSF3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPSF3L gene (6 alternative transcripts): NM_032179.1 NM_001256456.1 NM_001256460.1 NM_001256462.1 NM_001256463.1 NM_017871.5 Unigene Cluster for CPSF3L: Cleavage and polyadenylation specific factor 3-like Hs.6449 [show with all ESTs]Unigene Representative Sequence: BC04757618/48 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48): ENST00000470030 ENST00000435064(uc001aee.1 uc009vjz.1 uc001aeh.1)
ENST00000497304 ENST00000323275(uc001aeg.1) ENST00000411962(uc001aei.1)
ENST00000462432(uc009vjy.1) ENST00000478641 ENST00000421495(uc001aek.1)
ENST00000458452(uc001aef.1 uc010nyj.1) ENST00000419704 ENST00000532772
ENST00000450926 ENST00000527098 ENST00000485710 ENST00000461514 ENST00000525164
ENST00000528879 ENST00000525769
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CPSF3L (NM_017871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF3L |
Additional cDNA sequence: AK000549.1 AK021939.1 AK022675.1 AK023356.1 AK027767.1 AK056652.1 AK058018.1 AK092190.1 AK291387.1 AK297350.1 AL136813.1 BC000675.2 BC007978.2 BC008041.2 BC013904.2 BC020199.1 BC042444.1 BC047576.1 CR533557.1 24/42 DOTS entries (see all 42): DT.100862238 DT.100862242 DT.100862225 DT.455178 DT.100862228 DT.101985336 DT.95164263 DT.100031157 DT.121344420 DT.121344485 DT.92447042 DT.100862224 DT.95164246 DT.100862232 DT.121344451 DT.95164283 DT.100031155 DT.100862243 DT.121344508 DT.100862241 DT.121344466 DT.121344551 DT.100771371 DT.100862239 24/451 AceView cDNA sequences (see all 451): BQ950953 AI860840 AI571441 BM849355 AK123641 BE560076 AA682276 W93340 BF902765 AW247906 CR614665 AI084871 BG154171 AI972167 AI473542 BQ020831 BG013990 BM819988 BF340101 CR592541 BM918755 BM818827 AI290413 BE513665
GeneLoc Exon Structure
5/36 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3L (see all 36) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8a | · | 8b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CPSF3L
|
Expression
for CPSF3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPSF3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACACGCAA
About this image
See CPSF3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPSF3L
SOURCE GeneReport for Unigene cluster: Hs.6449
SABiosciences Custom PCR Arrays for CPSF3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPSF3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPSF3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPSF3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPSF3L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF3L |
Orthologs
for CPSF3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPSF3L gene from 8/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CPSF3L1 |
cleavage and polyadenylation specific factor 3-like |
78.67(n)
92(a) |
|
419418 NM_001012836.1 NP_001012854.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CPSF3L6 |
-- |
88(a) |
1 ↔ 1 |
GL343760.1(113771-135921) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.92052 |
Xenopus laevis transcribed sequence with weak similarity more |
75.15(n) |
|
BX844337.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.201572 |
Transcribed sequence with weak similarity to protein more |
80.47(n) |
|
CK024903.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
IntS111 |
Integrator 11 |
68.19(n)
68.75(a) |
|
43506 NM_143464.3 NP_651721.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F10B5.81 |
Protein F10B5.8 |
57.54(n)
61.68(a) |
|
174310 NM_063305.5 NP_495706.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CPSF73-II1 |
cleavage and polyadenylation specificity factor subunit more |
52.32(n)
47.17(a) |
|
814702 NM_126234.2 NP_178282.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.278232 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.39(n) |
|
AK101306.1 |
ENSEMBL Gene Tree for CPSF3L (if available)
TreeFam Gene Tree for CPSF3L (if available) |
Paralogs
for CPSF3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPSF3L gene
- CPSF22 CPSF32
1 SIMAP similar gene for CPSF3L using alignment to 22 protein entries: INT11_HUMAN (see all proteins):CPSF3
CPSF3L for paralogs About GeneDecksing
|
Genomic Variants
for CPSF3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPSF3L (1246965 - 1260071 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CPSF3L
3 CNVs: 0001 3275 30362 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPSF3L |
|
Disorders
/ Diseases
for CPSF3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPSF3L for disorders About GeneDecksing
OMIM gene information: 611354
OMIM disorders: --
6  diseases for CPSF3L: About MalaCardsfactor v and factor viii trigonitis meningitis seizures
crohn's disease malaria
4 Novoseek disease relationships for CPSF3L gene About this table
Human Genome Epidemiology (HuGE) Navigator: CPSF3L (3 documents)
Export disorders for CPSF3L gene to outside databases
|
Publications
for CPSF3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPSF3L gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with CPSF3L) | |  | Utopia: connect your pdf to the dynamic
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- A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PubMed id 15684398)1, 2, 3 Dominski Z.... Marzluff W.F. (2005)
- Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- snRNA 3' end formation requires heterodimeric associat ion of integrator subunits. (PubMed id 22252320)1 Albrecht T.R. and Wagner E.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for CPSF3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CPSF3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CPSF3L gene
(According to HUGE)
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Specialized Databases showing CPSF3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for CPSF3L gene:
Search GeneIP for patents involving CPSF3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CPSF3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPSF3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPSF3L | | | OriGene Protein Over-expression Lysate for CPSF3L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPSF3L | | OriGene 3'-UTR Clone for CPSF3L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF3L |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF3L |
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