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Aliases for CPSF3L Gene

Aliases for CPSF3L Gene

  • Cleavage And Polyadenylation Specific Factor 3-Like 2 3 5
  • Cleavage And Polyadenylation-Specific Factor 3-Like Protein 3 4
  • Protein Related To CPSF Subunits Of 68 KDa 3 4
  • Integrator Complex Subunit 11 2 3
  • CPSF3-Like Protein 3 4
  • INTS11 3 4
  • INT11 3 4
  • RC-68 3 4
  • RC68 3 4
  • Related To CPSF Subunits 68 KDa 3
  • EC 3.1.27.- 4
  • EC 3.1.27 61
  • CPSF73L 3

External Ids for CPSF3L Gene

Previous GeneCards Identifiers for CPSF3L Gene

  • GC01M001290
  • GC01M001236
  • GC01M000518
  • GC01M001249

Summaries for CPSF3L Gene

Entrez Gene Summary for CPSF3L Gene

  • The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF3L Gene

CPSF3L (Cleavage And Polyadenylation Specific Factor 3-Like) is a Protein Coding gene. Diseases associated with CPSF3L include Meningococcal Meningitis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CPSF3.

UniProtKB/Swiss-Prot for CPSF3L Gene

  • Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Gene Wiki entry for CPSF3L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF3L Gene

Genomics for CPSF3L Gene

Regulatory Elements for CPSF3L Gene

Enhancers for CPSF3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CPSF3L on UCSC Golden Path with GeneCards custom track

Genomic Location for CPSF3L Gene

Chromosome:
1
Start:
1,311,585 bp from pter
End:
1,324,691 bp from pter
Size:
13,107 bases
Orientation:
Minus strand

Genomic View for CPSF3L Gene

Genes around CPSF3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF3L Gene

Proteins for CPSF3L Gene

  • Protein details for CPSF3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA45-INT11_HUMAN
    Recommended name:
    Integrator complex subunit 11
    Protein Accession:
    Q5TA45
    Secondary Accessions:
    • A8K5S2
    • B3KPR3
    • B4DM87
    • G3V1S5
    • Q5TA46
    • Q5TA48
    • Q5TA52
    • Q5TA53
    • Q5TA54
    • Q7L3D7
    • Q96HY1
    • Q9BW36
    • Q9H0F9
    • Q9H8R5
    • Q9HAA6
    • Q9NWX9

    Protein attributes for CPSF3L Gene

    Size:
    600 amino acids
    Molecular mass:
    67663 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=BAA91246.1; Type=Frameshift; Positions=587; Evidence={ECO:0000305}; Sequence=BAB14541.1; Type=Frameshift; Positions=248; Evidence={ECO:0000305}; Sequence=CAI23174.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23176.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23177.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23179.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CPSF3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF3L Gene

Post-translational modifications for CPSF3L Gene

  • Ubiquitination at Lys 280, Lys 289, Lys 462, Lys 486, and Lys 500
  • Modification sites at PhosphoSitePlus

Domains & Families for CPSF3L Gene

Protein Domains for CPSF3L Gene

Graphical View of Domain Structure for InterPro Entry

Q5TA45

UniProtKB/Swiss-Prot:

INT11_HUMAN :
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
Domain:
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
genes like me logo Genes that share domains with CPSF3L: view

No data available for Gene Families for CPSF3L Gene

Function for CPSF3L Gene

Molecular function for CPSF3L Gene

UniProtKB/Swiss-Prot Function:
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.

Enzyme Numbers (IUBMB) for CPSF3L Gene

Gene Ontology (GO) - Molecular Function for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPSF3L: view
genes like me logo Genes that share phenotypes with CPSF3L: view

Animal Model Products

CRISPR Products

miRNA for CPSF3L Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF3L Gene

Localization for CPSF3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF3L Gene COMPARTMENTS Subcellular localization image for CPSF3L gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0032039 integrator complex IDA 16239144
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with CPSF3L: view

Pathways & Interactions for CPSF3L Gene

genes like me logo Genes that share pathways with CPSF3L: view

Pathways by source for CPSF3L Gene

2 Reactome pathways for CPSF3L Gene

Gene Ontology (GO) - Biological Process for CPSF3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CPSF3L: view

No data available for SIGNOR curated interactions for CPSF3L Gene

Drugs & Compounds for CPSF3L Gene

No Compound Related Data Available

Transcripts for CPSF3L Gene

Unigene Clusters for CPSF3L Gene

Cleavage and polyadenylation specific factor 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24: - - - - - - - -
SP25: - - - - - - -
SP26: - - - - - - - - - - - - - -
SP27: - - - - - - -
SP28: -
SP29: - - - - - -
SP30: - - - - -
SP31: - - - - - - -
SP32: -
SP33:
SP34:
SP35: - - - - - - - - - - - - - - - - - - - -
SP36:

ExUns: 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - -
SP18: -
SP19:
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32: - - - -
SP33: -
SP34:
SP35:
SP36:

ExUns: 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:

Relevant External Links for CPSF3L Gene

GeneLoc Exon Structure for
CPSF3L
ECgene alternative splicing isoforms for
CPSF3L

Expression for CPSF3L Gene

mRNA expression in normal human tissues for CPSF3L Gene

Protein differential expression in normal tissues from HIPED for CPSF3L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Liver, secretome (11.3), CD8 Tcells (7.9), and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPSF3L Gene



Protein tissue co-expression partners for CPSF3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPSF3L Gene:

CPSF3L

SOURCE GeneReport for Unigene cluster for CPSF3L Gene:

Hs.6449
genes like me logo Genes that share expression patterns with CPSF3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF3L Gene

Orthologs for CPSF3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF3L 34
  • 90.64 (n)
  • 97.16 (a)
CPSF3L 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF3L 34
  • 90.28 (n)
  • 97.5 (a)
CPSF3L 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf3l 34
  • 87.11 (n)
  • 97.17 (a)
Cpsf3l 16
Cpsf3l 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF3L 34
  • 96.05 (n)
  • 95.5 (a)
rat
(Rattus norvegicus)
Mammalia Cpsf3l 34
  • 87.28 (n)
  • 97 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF3L 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF3L 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF3L 34
  • 78.67 (n)
  • 92 (a)
CPSF3L 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF3L 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf3l 34
  • 75.94 (n)
  • 89.5 (a)
Str.7162 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9205 34
zebrafish
(Danio rerio)
Actinopterygii cpsf3l 34
  • 77.07 (n)
  • 84.4 (a)
Dr.20157 34
cpsf3l 35
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009923 34
  • 66.95 (n)
  • 69.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS11 34
  • 68.19 (n)
  • 68.75 (a)
IntS11 35
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10B5.8 34
  • 57.54 (n)
  • 61.68 (a)
F10B5.8 35
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSH1 35
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF73-II 34
  • 52.32 (n)
  • 47.17 (a)
rice
(Oryza sativa)
Liliopsida Os.27823 34
Os09g0397900 34
  • 57.28 (n)
  • 54.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4823 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToOne
Species where no ortholog for CPSF3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF3L Gene

ENSEMBL:
Gene Tree for CPSF3L (if available)
TreeFam:
Gene Tree for CPSF3L (if available)

Paralogs for CPSF3L Gene

Paralogs for CPSF3L Gene

genes like me logo Genes that share paralogs with CPSF3L: view

Variants for CPSF3L Gene

Sequence variations from dbSNP and Humsavar for CPSF3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1810745 -- 1,322,213(+) GAGGC(A/G)TGGGG intron-variant
rs1886772 -- 1,319,063(-) TGCAC(C/T)GGCTT intron-variant
rs1886773 -- 1,319,056(-) GCTTA(A/C/T)GAACC intron-variant
rs2296473 -- 1,314,848(-) GTCCA(C/T)GAGAC nc-transcript-variant, reference, synonymous-codon
rs4970432 -- 1,318,756(+) ATATA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF3L Gene

Variant ID Type Subtype PubMed ID
dgv26n54 CNV loss 21841781
dgv2n67 CNV gain 20364138
dgv6n100 CNV gain+loss 25217958
dgv7n100 CNV loss 25217958
esv2758912 CNV loss 17122850
esv3366182 CNV duplication 20981092
esv3547454 CNV deletion 23714750
esv3584992 CNV gain 21293372
esv3890636 CNV loss 25118596
nsv1000169 CNV gain 25217958
nsv1009541 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074436 CNV deletion 25765185
nsv1118092 CNV deletion 24896259
nsv1130939 CNV deletion 24896259
nsv1160772 CNV duplication 26073780
nsv1160788 CNV deletion 26073780
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv476469 CNV novel sequence insertion 20440878
nsv482937 CNV loss 15286789
nsv544969 CNV loss 21841781
nsv544971 CNV loss 21841781
nsv544972 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv997291 CNV gain 25217958

Variation tolerance for CPSF3L Gene

Residual Variation Intolerance Score: 6.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF3L Gene

Disorders for CPSF3L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPSF3L Gene - From: GeneCards

Disorder Aliases PubMed IDs
meningococcal meningitis
  • meningitis meningococcal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CPSF3L

Genetic Association Database (GAD)
CPSF3L
Human Genome Epidemiology (HuGE) Navigator
CPSF3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF3L
genes like me logo Genes that share disorders with CPSF3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPSF3L Gene

Publications for CPSF3L Gene

  1. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PMID: 15684398) Dominski Z. … Marzluff W.F. (Mol. Cell. Biol. 2005) 2 3 4 65
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for CPSF3L Gene

Sources for CPSF3L Gene

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