Aliases for CPSF3L Gene
External Ids for CPSF3L Gene
Previous GeneCards Identifiers for CPSF3L Gene
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CPSF3L Gene
CPSF3L (Cleavage And Polyadenylation Specific Factor 3-Like) is a Protein Coding gene. Diseases associated with CPSF3L include meningococcal meningitis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CPSF3.
UniProtKB/Swiss-Prot for CPSF3L Gene
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.