Aliases for CPSF3L Gene
External Ids for CPSF3L Gene
Previous GeneCards Identifiers for CPSF3L Gene
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CPSF3L Gene
CPSF3L (Cleavage And Polyadenylation Specific Factor 3-Like) is a Protein Coding gene. Diseases associated with CPSF3L include meningococcal meningitis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CPSF3.
UniProtKB/Swiss-Prot for CPSF3L Gene
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage.