Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPSF3 Gene

Aliases for CPSF3 Gene

  • Cleavage And Polyadenylation Specific Factor 3 2 3 5
  • Cleavage And Polyadenylation Specific Factor 3, 73kDa 2 3
  • MRNA 3-End-Processing Endonuclease CPSF-73 3 4
  • CPSF73 3 4
  • Cleavage And Polyadenylation Specificity Factor 73 KDa Subunit 4
  • Cleavage And Polyadenylation Specific Factor 3, 73kD Subunit 2
  • CPSF 73 KDa Subunit 4
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • CPSF-73 3

External Ids for CPSF3 Gene

Previous GeneCards Identifiers for CPSF3 Gene

  • GC02P009347
  • GC02P009615
  • GC02P009585
  • GC02P009514
  • GC02P009563

Summaries for CPSF3 Gene

Entrez Gene Summary for CPSF3 Gene

  • This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

GeneCards Summary for CPSF3 Gene

CPSF3 (Cleavage And Polyadenylation Specific Factor 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include RNA binding and 5-3 exonuclease activity. An important paralog of this gene is CPSF2.

UniProtKB/Swiss-Prot for CPSF3 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3-end-processing endonuclease. Also involved in the histone 3-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5 to 3 exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5-ACCCA-3 sequence in the histone pre-mRNA leaving a 3hydroxyl group on the upstream fragment containing the stem loop (SL) and 5 phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5 to 3 exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Gene Wiki entry for CPSF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF3 Gene

Genomics for CPSF3 Gene

Regulatory Elements for CPSF3 Gene

Enhancers for CPSF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPSF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPSF3 Gene

Chromosome:
2
Start:
9,423,537 bp from pter
End:
9,473,110 bp from pter
Size:
49,574 bases
Orientation:
Plus strand

Genomic View for CPSF3 Gene

Genes around CPSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF3 Gene

Proteins for CPSF3 Gene

  • Protein details for CPSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKF6-CPSF3_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 3
    Protein Accession:
    Q9UKF6
    Secondary Accessions:
    • O14769
    • Q53RS2
    • Q96F36

    Protein attributes for CPSF3 Gene

    Size:
    684 amino acids
    Molecular mass:
    77486 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF2, CSTF2 and SYMPK. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of pre-mRNAs. Interacts with WDR33. Interacts with ZC3H3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CPSF3 Gene

neXtProt entry for CPSF3 Gene

Proteomics data for CPSF3 Gene at MOPED

Post-translational modifications for CPSF3 Gene

  • Sumoylated on Lys-462, Lys-465 and Lys-545, preferentially by SUMO3.
  • Ubiquitination at Lys 295, Lys 306, Lys 428, and Lys 487
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF3 Gene

Domains & Families for CPSF3 Gene

Protein Domains for CPSF3 Gene

Suggested Antigen Peptide Sequences for CPSF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKF6

UniProtKB/Swiss-Prot:

CPSF3_HUMAN :
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.
genes like me logo Genes that share domains with CPSF3: view

No data available for Gene Families for CPSF3 Gene

Function for CPSF3 Gene

Molecular function for CPSF3 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3-end-processing endonuclease. Also involved in the histone 3-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5 to 3 exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5-ACCCA-3 sequence in the histone pre-mRNA leaving a 3hydroxyl group on the upstream fragment containing the stem loop (SL) and 5 phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5 to 3 exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Enzyme Numbers (IUBMB) for CPSF3 Gene

genes like me logo Genes that share phenotypes with CPSF3: view

Animal Models for CPSF3 Gene

MGI Knock Outs for CPSF3:

Animal Model Products

miRNA for CPSF3 Gene

miRTarBase miRNAs that target CPSF3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPSF3 Gene

Localization for CPSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF3 Gene COMPARTMENTS Subcellular localization image for CPSF3 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CPSF3 Gene

Pathways & Interactions for CPSF3 Gene

genes like me logo Genes that share pathways with CPSF3: view

Pathways by source for CPSF3 Gene

Gene Ontology (GO) - Biological Process for CPSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006379 mRNA cleavage TAS 8929409
GO:0006406 mRNA export from nucleus TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CPSF3: view

No data available for SIGNOR curated interactions for CPSF3 Gene

Drugs & Compounds for CPSF3 Gene

(1) Drugs for CPSF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CPSF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPSF3: view

Transcripts for CPSF3 Gene

Unigene Clusters for CPSF3 Gene

Cleavage and polyadenylation specific factor 3, 73kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for CPSF3 Gene

GeneLoc Exon Structure for
CPSF3
ECgene alternative splicing isoforms for
CPSF3

Expression for CPSF3 Gene

mRNA expression in normal human tissues for CPSF3 Gene

Protein differential expression in normal tissues from HIPED for CPSF3 Gene

This gene is overexpressed in Lymph node (15.8), Fetal ovary (6.6), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF3 Gene



SOURCE GeneReport for Unigene cluster for CPSF3 Gene Hs.515972

genes like me logo Genes that share expression patterns with CPSF3: view

Protein tissue co-expression partners for CPSF3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF3 Gene

Orthologs for CPSF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF3 35
  • 93.13 (n)
  • 99.56 (a)
CPSF3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF3 35
  • 92.74 (n)
  • 99.42 (a)
CPSF3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf3 35
  • 89.04 (n)
  • 98.54 (a)
Cpsf3 16
Cpsf3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF3 35
  • 99.42 (n)
  • 99.85 (a)
CPSF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf3 35
  • 88.56 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF3 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF3 35
  • 82.86 (n)
  • 95.05 (a)
CPSF3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF3 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf3 35
  • 78.61 (n)
  • 90.01 (a)
Str.6057 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16076 35
zebrafish
(Danio rerio)
Actinopterygii cpsf3 35
  • 75.9 (n)
  • 88.95 (a)
wufc32f10 35
cpsf3 36
  • 88 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12326 35
fruit fly
(Drosophila melanogaster)
Insecta CG1972 37
  • 40 (a)
CG7698 37
  • 65 (a)
Cpsf73 35
  • 62.58 (n)
  • 68.31 (a)
Cpsf73 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001224 35
  • 61.87 (n)
  • 68.67 (a)
worm
(Caenorhabditis elegans)
Secernentea F10B5.8 37
  • 39 (a)
Y67H2A.1 37
  • 58 (a)
cpsf-3 35
  • 61.52 (n)
  • 61.14 (a)
cpsf-3 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR279C 35
  • 54.43 (n)
  • 51.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04598g 35
  • 55.37 (n)
  • 49.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSH1 35
  • 56.13 (n)
  • 47.64 (a)
YSH1 36
  • 38 (a)
OneToMany
YSH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF73-I 35
  • 57.06 (n)
  • 56.26 (a)
rice
(Oryza sativa)
Liliopsida Os.9048 35
Os03g0852900 35
  • 56.39 (n)
  • 55.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03479 35
  • 51.5 (n)
  • 47.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ysh1 35
  • 55.77 (n)
  • 49.4 (a)
Species with no ortholog for CPSF3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF3 Gene

ENSEMBL:
Gene Tree for CPSF3 (if available)
TreeFam:
Gene Tree for CPSF3 (if available)

Paralogs for CPSF3 Gene

Paralogs for CPSF3 Gene

(1) SIMAP similar genes for CPSF3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPSF3: view

Variants for CPSF3 Gene

Sequence variations from dbSNP and Humsavar for CPSF3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035873 A breast cancer sample
rs17850770 - 9,432,594(+) TCATG(A/G)AGTTA reference, missense
rs2002044 -- 9,430,925(-) TACAT(A/G)CCATA intron-variant
rs4991977 -- 9,462,178(+) CGCAG(C/T)TTTCA intron-variant
rs5829212 -- 9,455,152(+) TTTTT(-/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF3 Gene

Variant ID Type Subtype PubMed ID
nsv2602 CNV Loss 18451855
nsv514992 CNV Complex 21397061

Variation tolerance for CPSF3 Gene

Residual Variation Intolerance Score: 9.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPSF3 Gene

Disorders for CPSF3 Gene

Relevant External Links for CPSF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF3

No disorders were found for CPSF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF3 Gene

Publications for CPSF3 Gene

  1. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. (PMID: 17128255) Mandel C.R. … Tong L. (Nature 2006) 3 4 23 67
  2. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. (PMID: 19136632) Rozenblatt-Rosen O. … Meyerson M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PMID: 18688255) Kolev N.G. … Steitz J.A. (EMBO Rep. 2008) 3 23
  4. The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. (PMID: 17669424) de la Vega L. … Calzado M.A. (J. Mol. Biol. 2007) 3 23
  5. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 23

Products for CPSF3 Gene

Sources for CPSF3 Gene

Content