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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPSF2 Gene

protein-coding   GIFtS: 61
GCID: GC14P092588

cleavage and polyadenylation specific factor 2, 100kDa

(Previous names: cleavage and polyadenylation specific factor 2, 100kD subunit...)
  Search for CPSF2
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cleavage And Polyadenylation Specific Factor 2, 100kDa1 2     CPSF 100 KDa Subunit2 3
KIAA13671 3     Cleavage And Polyadenylation Specific Factor 2, 100kD Subunit1
Cleavage And Polyadenylation Specificity Factor 100 KDa Subunit2 3     Cleavage And Polyadenylation Specificity Factor Subunit 22
CPSF1002 3     CPSF 100kDa Subunit2

External Ids:    HGNC: 23251   Entrez Gene: 539812   Ensembl: ENSG000001659347   OMIM: 6060285   UniProtKB: Q9P2I03   

Export aliases for CPSF2 gene to outside databases

Previous GC identifers: GC14P090094 GC14P086404 GC14P090578 GC14P091658 GC14P072769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CPSF2_HUMAN, Q9P2I0
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in
pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other
factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing

Gene Wiki entry for CPSF2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPSF2 gene promoter:
         TBP   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPSF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPSF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q31.1

CPSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPSF2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P092588:  view genomic region     (about GC identifiers)

Start:
92,588,281 bp from pter      End:
92,630,755 bp from pter
Size:
42,475 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CPSF2_HUMAN, Q9P2I0 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 2  
Size: 782 amino acids; 88487 Da
Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2,
CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK
Subcellular location: Nucleus (Potential)
Secondary accessions: B3KME1 Q6NSJ1 Q9H3W7

Explore the universe of human proteins at neXtProt for CPSF2: NX_Q9P2I0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2I0

  • CPSF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059133.1  
    ENSEMBL proteins: 
     ENSP00000298875   ENSP00000451418   ENSP00000452503   ENSP00000451390  
    Reactome Protein details: Q9P2I0
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPSF2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005847mRNA cleavage and polyadenylation specificity factor complex IDA18305108


    CPSF2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CPSF2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011108 RMMBL
     IPR027075 CPSF2
     IPR001279 Beta-lactamas-like
     IPR025069 Cpsf2_C
     IPR022712 Beta_Casp

    Graphical View of Domain Structure for InterPro Entry Q9P2I0

    ProtoNet protein and cluster: Q9P2I0

    1 Blocks protein family: IPB011108 RNA-metabolising metallo-beta-lactamase

    UniProtKB/Swiss-Prot: CPSF2_HUMAN, Q9P2I0
    Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.
    CPSF2/YSH1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CPSF2_HUMAN, Q9P2I0
    Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in
    pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other
    factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF2 (see all 33):
    hsa-miR-579 hsa-miR-4328 hsa-miR-1258 hsa-miR-138-2* hsa-miR-29b-1* hsa-miR-570 hsa-miR-10b* hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCPSF2 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI18688255
    GO:0016787hydrolase activity IEA--


    CPSF2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CPSF2:
     Increased S DNA content  Increased cell size  S arrest  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination1.00
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    Post-Elongation Processing of the Transcript1.00
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    mRNA Processing0.82
    mRNA Splicing - Major Pathway1.00
    mRNA processing0.48
    Processing of Capped Intron-Containing Pre-mRNA0.96
    3Post-Elongation Processing of Intronless pre-mRNA
    Processing of Capped Intronless Pre-mRNA1.00
    Processing of Intronless Pre-mRNAs0.61
    Post-Elongation Processing of Intronless pre-mRNA1.00
    4Transport of Mature mRNA Derived from an Intronless Transcript
    Transport of Mature mRNA Derived from an Intronless Transcript1.00
    Transport of Mature mRNAs Derived from Intronless Transcripts0.89
    5Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CPSF2 
        mRNA processing

    5/18        Reactome Pathways for CPSF2 (see all 18)
        Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    Transport of Mature mRNA Derived from an Intronless Transcript
    RNA Polymerase II Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CPSF2):
        mRNA surveillance pathway


    CPSF2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/811 Interacting proteins for CPSF2 (Q9P2I02, 3 ENSP000002988754) via UniProtKB, MINT, STRING, and/or I2D (see all 811)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF3Q9UKF62, ENSP000002381124MINT-6802591 MINT-8198073 MINT-6802527 MINT-7947479 MINT-7945693 MINT-6802510 MINT-6802560 MINT-6802545 MINT-8089129 MINT-6802610 STRING: ENSP00000238112
    CSTF2P332402, 3, ENSP000003620634MINT-6802591 MINT-6802527 MINT-6802639 MINT-6802510 MINT-6802560 MINT-6802545 MINT-8089129 I2D: score=2 STRING: ENSP00000362063
    SYMPKQ927972, 3, ENSP000002459344MINT-8198073 MINT-7947479 MINT-6802626 MINT-7945693 MINT-6802510 MINT-6802610 I2D: score=1 STRING: ENSP00000245934
    CLP1Q929892, 3, ENSP000003047044MINT-7945693 I2D: score=1 STRING: ENSP00000304704
    CDC73Q6P1J92, 3, ENSP000003564054MINT-7947479 MINT-7945693 I2D: score=1 STRING: ENSP00000356405
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS--
    GO:0006398histone mRNA 3'-end processing IDA18688255


    CPSF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPSF2
    Search CenterWatch for drugs/clinical trials and news about CPSF2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPSF2 gene: 
    NM_017437.2  

    Unigene Cluster for CPSF2:

    Cleavage and polyadenylation specific factor 2, 100kDa
    Hs.657632  [show with all ESTs]
    Unigene Representative Sequence: NM_017437
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298875(uc001yah.2) ENST00000553427 ENST00000554290 ENST00000556622
    ENST00000555244

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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CPSF2 (see all 33):
    hsa-miR-579 hsa-miR-4328 hsa-miR-1258 hsa-miR-138-2* hsa-miR-29b-1* hsa-miR-570 hsa-miR-10b* hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCPSF2 3' UTR sequence
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    Additional cDNA sequence: 

    AB037788.1 AK001627.2 AK001912.1 AK023583.1 AL442079.1 BC060854.1 BC070095.1 

    6 DOTS entries:

    DT.455215  DT.120776671  DT.100718716  DT.120776666  DT.91977588  DT.100888885 

    24/168 AceView cDNA sequences (see all 168):

    BQ229374 NM_017437 AL040352 AK001912 CD514291 T08258 AK023583 BM831795 
    BM854763 BQ961605 BC060854 AA176202 BM788365 AB037788 BM827073 CK823581 
    BG282994 AA171479 BE535330 CB158583 AA629779 AA176203 BU071341 BQ129215 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -                                                                                                                     
    SP2:              -                                   -     -     -     -                                                               
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for CPSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCCTCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CPSF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPSF2

    SOURCE GeneReport for Unigene cluster: Hs.657632
        SABiosciences Custom PCR Arrays for CPSF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPSF2 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpsf21 , 5 cleavage and polyadenylation specific factor 21, 5 88.7(n)1
    97.95(a)1
      12 (51.34 cM)5
    517861  NM_016856.31  NP_058552.11 
     1019759745 
    chicken
    (Gallus gallus)
    Aves CPSF21 cleavage and polyadenylation specific factor 2, 10 more 84.21(n)
    96.16(a)
      423416  NM_001031208.1  NP_001026379.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPSF26
    --
    95(a)
    1 ↔ 1
    1(11624081-11639938)
    African clawed frog
    (Xenopus laevis)
    Amphibia cpsf2-A2 cleavage and polyadenylation specific factor 2, 10 more 79.94(n)    AF139986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125262 Transcribed sequence with moderate similarity to protein more 75.64(n)    BQ481309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD141683
    Cpsf1001
    mRNA cleavage mRNA binding, 3' UTR3
    Cleavage and polyadenylation specificity factor 10 more1
    53(a)3
    57.23(n)1
    58.91(a)1
      98F53
    434261  NM_143401.21  NP_651658.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F09G2.43
    cpsf-21
    Protein CPSF-21 41(a)3
    53.36(n)1
    45.19(a)1
      V(7181807-7185393)3
    1791031  NM_072421.31  NP_504822.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CPSF1001 cleavage and polyadenylation specificity factor subunit more 50.65(n)
    41.9(a)
      832453  NM_122293.3  NP_197776.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05694001 hypothetical protein 50.68(n)
    42.6(a)
      4347905  NM_001070513.1  NP_001063978.1 


    ENSEMBL Gene Tree for CPSF2 (if available)
    TreeFam Gene Tree for CPSF2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPSF2 gene
    CPSF3L2  CPSF32  

    CPSF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/685 NCBI SNPs in CPSF2 are shown (see all 685    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580364461,2
    C,F,--92590192(+) ACTGAA/CGTTGG 1 -- int16Minor allele frequency- C:0.28NA WA CSA EA 364
    rs1823768111,2
    --92590210(+) TATACA/GAAGAT 1 -- int10--------
    rs1492914241,2
    --92590266(+) CTTTAA/TGTGCC 1 -- int10--------
    rs1462857101,2
    --92590312(+) AACAAA/CAAGGC 1 -- int10--------
    rs1394088641,2
    --92590392(+) AAGGTA/CATTTC 1 -- int10--------
    rs1881822831,2
    --92590426(+) GCTTTC/GAGAAG 1 -- int10--------
    rs71519321,2
    C,F,A,H,--92590564(+) ATTTTA/TTTCAG 1 -- int113Minor allele frequency- T:0.39NS EA NA WA CSA 788
    rs1173435691,2
    F,--92590622(+) GGATAT/CTTGTT 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1123772491,2
    --92590737(+) TGGAGG/ACAGGA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs71523351,2
    C,F,A,H,--92590839(+) TAGTCT/CGGGAG 1 -- int110Minor allele frequency- C:0.26NA WA CSA EA 508

    HapMap Linkage Disequilibrium report for CPSF2 (92588281 - 92630755 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CPSF2
         1 CNV: 23492

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CPSF2 for disorders           About MalaCards

    CPSF2 for disorders           About GeneDecksing

    OMIM gene information: 606028    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CPSF2:
    Rift Valley fever
    Human Genome Epidemiology (HuGE) Navigator: CPSF2 (1 document)

    Export disorders for CPSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPSF2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CPSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PubMed id 18688255)1, 2 Kolev N.G.... Steitz J.A. (2008)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2 Kaufmann I.... Keller W. (2004)
    6. Assignment of the 100-kDa subunit of cleavage and polyadenylation specificity factor (CPSF2) to human chromosome 14q31.3 by radiation hybrid mapping. (PubMed id 11124543)1, 3 Samiotaki M....Tsiapalis C.M. (2000)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. (PubMed id 7969155)1, 3 Jenny A....Keller W. (1994)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53981 HGNC: 2325 AceView: CPSF2 Ensembl:ENSG00000165934 euGenes: HUgn53981
    ECgene: CPSF2 Kegg: 53981 H-InvDB: CPSF2

    (According to HUGE)
    About This Section
    HUGE: KIAA1367

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPSF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPSF2 gene:
    Search GeneIP for patents involving CPSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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