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Aliases for CPSF2 Gene

Aliases for CPSF2 Gene

  • Cleavage And Polyadenylation Specific Factor 2, 100kDa 2 3
  • Cleavage And Polyadenylation Specificity Factor 100 KDa Subunit 3 4
  • CPSF 100 KDa Subunit 3 4
  • CPSF100 3 4
  • Cleavage And Polyadenylation Specific Factor 2, 100kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 2 3
  • CPSF 100kDa Subunit 3
  • KIAA1367 4

External Ids for CPSF2 Gene

Previous GeneCards Identifiers for CPSF2 Gene

  • GC14P090094
  • GC14P086404
  • GC14P090578
  • GC14P091658
  • GC14P092588
  • GC14P072769

Summaries for CPSF2 Gene

GeneCards Summary for CPSF2 Gene

CPSF2 (Cleavage And Polyadenylation Specific Factor 2, 100kDa) is a Protein Coding gene. Diseases associated with CPSF2 include rift valley fever. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and hydrolase activity.

UniProtKB/Swiss-Prot for CPSF2 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Gene Wiki entry for CPSF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF2 Gene

Genomics for CPSF2 Gene

Regulatory Elements for CPSF2 Gene

Transcription factor binding sites by QIAGEN in the CPSF2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPSF2 Gene

Start:
92,121,937 bp from pter
End:
92,172,145 bp from pter
Size:
50,209 bases
Orientation:
Plus strand

Genomic View for CPSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF2 Gene

Proteins for CPSF2 Gene

  • Protein details for CPSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2I0-CPSF2_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 2
    Protein Accession:
    Q9P2I0
    Secondary Accessions:
    • B3KME1
    • Q6NSJ1
    • Q9H3W7

    Protein attributes for CPSF2 Gene

    Size:
    782 amino acids
    Molecular mass:
    88487 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK.

neXtProt entry for CPSF2 Gene

Proteomics data for CPSF2 Gene at MOPED

Post-translational modifications for CPSF2 Gene

  • Ubiquitination at Lys130, Lys324, Lys375, and Lys725
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CPSF2 Gene

Domains for CPSF2 Gene

Protein Domains for CPSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2I0

UniProtKB/Swiss-Prot:

CPSF2_HUMAN :
  • Q9P2I0
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
genes like me logo Genes that share domains with CPSF2: view

No data available for Gene Families for CPSF2 Gene

Function for CPSF2 Gene

Molecular function for CPSF2 Gene

UniProtKB/Swiss-Prot Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Gene Ontology (GO) - Molecular Function for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 18688255
genes like me logo Genes that share ontologies with CPSF2: view

Phenotypes for CPSF2 Gene

genes like me logo Genes that share phenotypes with CPSF2: view

Animal Model Products

CRISPR Products

miRNA for CPSF2 Gene

miRTarBase miRNAs that target CPSF2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPSF2 Gene

Localization for CPSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF2 Gene COMPARTMENTS Subcellular localization image for CPSF2 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 18305108
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CPSF2: view

Pathways for CPSF2 Gene

genes like me logo Genes that share pathways with CPSF2: view

Gene Ontology (GO) - Biological Process for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA --
GO:0006379 mRNA cleavage IEA --
genes like me logo Genes that share ontologies with CPSF2: view

Transcripts for CPSF2 Gene

Unigene Clusters for CPSF2 Gene

Cleavage and polyadenylation specific factor 2, 100kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - -
SP3:

Relevant External Links for CPSF2 Gene

GeneLoc Exon Structure for
CPSF2
ECgene alternative splicing isoforms for
CPSF2

Expression for CPSF2 Gene

mRNA expression in normal human tissues for CPSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPSF2 Gene

SOURCE GeneReport for Unigene cluster for CPSF2 Gene Hs.657632

genes like me logo Genes that share expressions with CPSF2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF2 Gene

Orthologs for CPSF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF2 35
  • 99.7 (n)
  • 100 (a)
CPSF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF2 35
  • 93.52 (n)
  • 99.62 (a)
CPSF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF2 35
  • 93.82 (n)
  • 99.62 (a)
CPSF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf2 35
  • 88.7 (n)
  • 97.95 (a)
Cpsf2 16
Cpsf2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf2 35
  • 89.09 (n)
  • 98.34 (a)
chicken
(Gallus gallus)
Aves CPSF2 35
  • 84.21 (n)
  • 96.16 (a)
CPSF2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF2 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cpsf2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf2 35
  • 79.41 (n)
  • 92.2 (a)
zebrafish
(Danio rerio)
Actinopterygii cpsf2 35
  • 72.98 (n)
  • 86.45 (a)
cpsf2 36
  • 86 (a)
OneToOne
Dr.12526 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002474 35
  • 56.64 (n)
  • 58.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cpsf100 35
  • 56.94 (n)
  • 58.34 (a)
Cpsf100 36
  • 57 (a)
OneToOne
BcDNA:LD14168 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea cpsf-2 35
  • 53.63 (n)
  • 45.34 (a)
cpsf-2 36
  • 41 (a)
OneToOne
F09G2.4 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT2 36
  • 21 (a)
OneToOne
CFT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF100 35
  • 50.51 (n)
  • 41.48 (a)
rice
(Oryza sativa)
Liliopsida Os09g0569400 35
  • 50.35 (n)
  • 41.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13623 35
Species with no ortholog for CPSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF2 Gene

ENSEMBL:
Gene Tree for CPSF2 (if available)
TreeFam:
Gene Tree for CPSF2 (if available)

Paralogs for CPSF2 Gene

No data available for Paralogs for CPSF2 Gene

Variants for CPSF2 Gene

Sequence variations from dbSNP and Humsavar for CPSF2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1126949 -- 92,163,982(+) gcctg(A/G)gcctc utr-variant-3-prime
rs1241681 -- 92,136,967(+) CAAAG(G/T)AAAAG intron-variant
rs1261708 -- 92,139,648(+) attct(C/T)ctgcc intron-variant
rs1263283 -- 92,139,682(+) tacag(G/T)catgc intron-variant
rs1263284 -- 92,139,711(+) ttttt(A/G)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF2 Gene

Variant ID Type Subtype PubMed ID
dgv1975n71 CNV Loss 21882294
nsv902190 CNV Loss 21882294
nsv1397 CNV Insertion 18451855
esv999869 CNV Insertion 20482838
esv1267299 CNV Insertion 17803354

Relevant External Links for CPSF2 Gene

HapMap Linkage Disequilibrium report
CPSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF2 Gene

Disorders for CPSF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CPSF2 Gene including...

Search for CPSF2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CPSF2 Gene

Relevant External Links for CPSF2

Genetic Association Database (GAD)
CPSF2
Human Genome Epidemiology (HuGE) Navigator
CPSF2
genes like me logo Genes that share disorders with CPSF2: view

No data available for UniProtKB/Swiss-Prot for CPSF2 Gene

Publications for CPSF2 Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 48
  2. Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. (PMID: 7969155) Jenny A. … Keller W. (Mol. Cell. Biol. 1994) 2 3
  3. Assignment of the 100-kDa subunit of cleavage and polyadenylation specificity factor (CPSF2) to human chromosome 14q31.3 by radiation hybrid mapping. (PMID: 11124543) Samiotaki M. … Tsiapalis C.M. (Cytogenet. Cell Genet. 2000) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CPSF2 Gene

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