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Aliases for CPSF2 Gene

Aliases for CPSF2 Gene

  • Cleavage And Polyadenylation Specific Factor 2 2 3 5
  • Cleavage And Polyadenylation Specificity Factor 100 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 2, 100kDa 2 3
  • CPSF 100 KDa Subunit 3 4
  • CPSF100 3 4
  • Cleavage And Polyadenylation Specific Factor 2, 100kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 2 3
  • CPSF 100kDa Subunit 3
  • KIAA1367 4

External Ids for CPSF2 Gene

Previous GeneCards Identifiers for CPSF2 Gene

  • GC14P090094
  • GC14P086404
  • GC14P090578
  • GC14P091658
  • GC14P092588
  • GC14P072769

Summaries for CPSF2 Gene

GeneCards Summary for CPSF2 Gene

CPSF2 (Cleavage And Polyadenylation Specific Factor 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Termination and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CPSF2 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Gene Wiki entry for CPSF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF2 Gene

Genomics for CPSF2 Gene

Regulatory Elements for CPSF2 Gene

Enhancers for CPSF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CPSF2 on UCSC Golden Path with GeneCards custom track

Promoters for CPSF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the CPSF2 gene promoter:

Genomic Location for CPSF2 Gene

Chromosome:
14
Start:
92,121,937 bp from pter
End:
92,172,145 bp from pter
Size:
50,209 bases
Orientation:
Plus strand

Genomic View for CPSF2 Gene

Genes around CPSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF2 Gene

Proteins for CPSF2 Gene

  • Protein details for CPSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2I0-CPSF2_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 2
    Protein Accession:
    Q9P2I0
    Secondary Accessions:
    • B3KME1
    • Q6NSJ1
    • Q9H3W7

    Protein attributes for CPSF2 Gene

    Size:
    782 amino acids
    Molecular mass:
    88487 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK. Interacts with ZC3H3 (By similarity).

neXtProt entry for CPSF2 Gene

Post-translational modifications for CPSF2 Gene

  • Ubiquitination at Lys 130, Lys 324, Lys 375, and Lys 725
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF2 Gene

Antibody Products

  • Abcam antibodies for CPSF2

No data available for DME Specific Peptides for CPSF2 Gene

Domains & Families for CPSF2 Gene

Protein Domains for CPSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2I0

UniProtKB/Swiss-Prot:

CPSF2_HUMAN :
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
genes like me logo Genes that share domains with CPSF2: view

No data available for Gene Families for CPSF2 Gene

Function for CPSF2 Gene

Molecular function for CPSF2 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Gene Ontology (GO) - Molecular Function for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 18688255
genes like me logo Genes that share ontologies with CPSF2: view
genes like me logo Genes that share phenotypes with CPSF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF2 Gene

Localization for CPSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF2 Gene COMPARTMENTS Subcellular localization image for CPSF2 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA,IDA 18305108
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CPSF2: view

Pathways & Interactions for CPSF2 Gene

genes like me logo Genes that share pathways with CPSF2: view

Pathways by source for CPSF2 Gene

Gene Ontology (GO) - Biological Process for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA --
GO:0006379 mRNA cleavage IEA --
GO:0006398 mRNA 3-end processing by stem-loop binding and cleavage IDA 18688255
genes like me logo Genes that share ontologies with CPSF2: view

No data available for SIGNOR curated interactions for CPSF2 Gene

Drugs & Compounds for CPSF2 Gene

No Compound Related Data Available

Transcripts for CPSF2 Gene

Unigene Clusters for CPSF2 Gene

Cleavage and polyadenylation specific factor 2, 100kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - -
SP3:

Relevant External Links for CPSF2 Gene

GeneLoc Exon Structure for
CPSF2
ECgene alternative splicing isoforms for
CPSF2

Expression for CPSF2 Gene

mRNA expression in normal human tissues for CPSF2 Gene

Protein differential expression in normal tissues from HIPED for CPSF2 Gene

This gene is overexpressed in Lymph node (14.2), Peripheral blood mononuclear cells (6.7), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPSF2 Gene



Protein tissue co-expression partners for CPSF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPSF2 Gene:

CPSF2

SOURCE GeneReport for Unigene cluster for CPSF2 Gene:

Hs.657632
genes like me logo Genes that share expression patterns with CPSF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF2 Gene

Orthologs for CPSF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF2 34
  • 93.52 (n)
  • 99.62 (a)
CPSF2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF2 34
  • 93.82 (n)
  • 99.62 (a)
CPSF2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf2 34
  • 88.7 (n)
  • 97.95 (a)
Cpsf2 16
Cpsf2 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF2 34
  • 99.7 (n)
  • 100 (a)
CPSF2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf2 34
  • 89.09 (n)
  • 98.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF2 35
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF2 34
  • 84.21 (n)
  • 96.16 (a)
CPSF2 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf2 34
  • 79.41 (n)
  • 92.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia cpsf2-A 34
zebrafish
(Danio rerio)
Actinopterygii cpsf2 34
  • 72.98 (n)
  • 86.45 (a)
Dr.12526 34
cpsf2 35
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD14168 36
  • 53 (a)
Cpsf100 34
  • 56.94 (n)
  • 58.34 (a)
Cpsf100 35
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002474 34
  • 56.64 (n)
  • 58.23 (a)
worm
(Caenorhabditis elegans)
Secernentea F09G2.4 36
  • 41 (a)
cpsf-2 34
  • 53.63 (n)
  • 45.34 (a)
cpsf-2 35
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT2 35
  • 21 (a)
OneToOne
CFT2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF100 34
  • 50.51 (n)
  • 41.48 (a)
rice
(Oryza sativa)
Liliopsida Os09g0569400 34
  • 50.35 (n)
  • 41.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13623 34
Species where no ortholog for CPSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF2 Gene

ENSEMBL:
Gene Tree for CPSF2 (if available)
TreeFam:
Gene Tree for CPSF2 (if available)

Paralogs for CPSF2 Gene

No data available for Paralogs for CPSF2 Gene

Variants for CPSF2 Gene

Sequence variations from dbSNP and Humsavar for CPSF2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2402113 -- 92,136,543(+) ACCTG(C/T)GATCA intron-variant
rs7141379 -- 92,126,414(+) GTGGT(A/G/T)CAGTA intron-variant
rs7142318 -- 92,164,621(+) TAAAA(A/T)GAAAT downstream-variant-500B
rs7144605 -- 92,144,259(+) gtgta(A/T)gatct intron-variant
rs9323871 -- 92,145,346(+) CCTAC(A/C/T)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF2 Gene

Variant ID Type Subtype PubMed ID
esv1267299 CNV insertion 17803354
esv3635331 CNV loss 21293372
esv999869 CNV insertion 20482838
nsv1397 CNV insertion 18451855
nsv472736 CNV novel sequence insertion 20440878

Variation tolerance for CPSF2 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF2 Gene

Disorders for CPSF2 Gene

Relevant External Links for CPSF2

Genetic Association Database (GAD)
CPSF2
Human Genome Epidemiology (HuGE) Navigator
CPSF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF2

No disorders were found for CPSF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF2 Gene

Publications for CPSF2 Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 46 65
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 65
  3. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PMID: 21102410) Laishram R.S. … Anderson R.A. (EMBO J. 2010) 3 4 65
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 65
  5. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PMID: 18688255) Kolev N.G. … Steitz J.A. (EMBO Rep. 2008) 3 4 65

Products for CPSF2 Gene

Sources for CPSF2 Gene

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