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Aliases for CPSF1 Gene

Aliases for CPSF1 Gene

  • Cleavage And Polyadenylation Specific Factor 1, 160kDa 2 3
  • Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 3 4
  • CPSF 160 KDa Subunit 3 4
  • CPSF160 3 4
  • Cleavage And Polyadenylation Specific Factor 1, 160kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 1 3
  • Polyadenylation Specificity Factor 3
  • HSU37012 3
  • P/Cl.18 3

External Ids for CPSF1 Gene

Previous GeneCards Identifiers for CPSF1 Gene

  • GC08M143221
  • GC08M145623
  • GC08M145223
  • GC08M145589
  • GC08M145618
  • GC08M140731

Summaries for CPSF1 Gene

Entrez Gene Summary for CPSF1 Gene

  • Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF1 Gene

CPSF1 (Cleavage And Polyadenylation Specific Factor 1, 160kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include mRNA 3-UTR binding.

UniProtKB/Swiss-Prot for CPSF1 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Wiki entry for CPSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF1 Gene

Genomics for CPSF1 Gene

Regulatory Elements for CPSF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPSF1 Gene

Start:
144,393,229 bp from pter
End:
144,409,381 bp from pter
Size:
16,153 bases
Orientation:
Minus strand

Genomic View for CPSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF1 Gene

Proteins for CPSF1 Gene

  • Protein details for CPSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10570-CPSF1_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 1
    Protein Accession:
    Q10570
    Secondary Accessions:
    • Q96AF0

    Protein attributes for CPSF1 Gene

    Size:
    1443 amino acids
    Molecular mass:
    160884 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.

neXtProt entry for CPSF1 Gene

Proteomics data for CPSF1 Gene at MOPED

Post-translational modifications for CPSF1 Gene

  • The N-terminus is blocked
  • Ubiquitination at Lys52, Lys116, Lys364, Lys395, Lys809, Lys847, Lys1104, Lys1118, Lys1241, and Lys1421
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CPSF1 Gene

Domains for CPSF1 Gene

Protein Domains for CPSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q10570

UniProtKB/Swiss-Prot:

CPSF1_HUMAN :
  • Belongs to the CPSF1 family.
Family:
  • Belongs to the CPSF1 family.
genes like me logo Genes that share domains with CPSF1: view

No data available for Gene Families for CPSF1 Gene

Function for CPSF1 Gene

Molecular function for CPSF1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Ontology (GO) - Molecular Function for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003730 mRNA 3-UTR binding IDA 7590244
GO:0005515 protein binding IPI 21102410
genes like me logo Genes that share ontologies with CPSF1: view

Phenotypes for CPSF1 Gene

GenomeRNAi human phenotypes for CPSF1:
genes like me logo Genes that share phenotypes with CPSF1: view

Animal Model Products

miRNA for CPSF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF1 Gene

Localization for CPSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF1 Gene COMPARTMENTS Subcellular localization image for CPSF1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 21102410
genes like me logo Genes that share ontologies with CPSF1: view

Pathways for CPSF1 Gene

genes like me logo Genes that share pathways with CPSF1: view

Gene Ontology (GO) - Biological Process for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IDA 7590244
GO:0006379 mRNA cleavage IDA 7590244
genes like me logo Genes that share ontologies with CPSF1: view

Drugs for CPSF1 Gene

(2) Novoseek inferred chemical compound relationships for CPSF1 Gene

Compound -log(P) Hits PubMed IDs
adenylate 63.8 8
zinc 21.2 1
genes like me logo Genes that share compounds with CPSF1: view

Transcripts for CPSF1 Gene

Unigene Clusters for CPSF1 Gene

Cleavage and polyadenylation specific factor 1, 160kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPSF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28:
SP29:
SP30:

ExUns: 33a · 33b ^ 34 ^ 35a · 35b ^ 36a · 36b · 36c ^ 37a · 37b · 37c · 37d · 37e ^ 38 ^ 39 ^ 40a · 40b · 40c ^ 41a · 41b · 41c ^ 42a · 42b ^ 43
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27:
SP28:
SP29:
SP30:

Relevant External Links for CPSF1 Gene

GeneLoc Exon Structure for
CPSF1
ECgene alternative splicing isoforms for
CPSF1

Expression for CPSF1 Gene

mRNA expression in normal human tissues for CPSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CPSF1 Gene

This gene is overexpressed in Liver, secretome (18.5), Peripheral blood mononuclear cells (9.7), and Lymph node (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CPSF1 Gene

SOURCE GeneReport for Unigene cluster for CPSF1 Gene Hs.493202

genes like me logo Genes that share expressions with CPSF1: view

Expression partners for CPSF1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF1 Gene

Orthologs for CPSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF1 35
  • 90.12 (n)
  • 96.39 (a)
CPSF1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF1 35
  • 90.39 (n)
  • 96.63 (a)
CPSF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf1 35
  • 87.65 (n)
  • 96.67 (a)
Cpsf1 16
Cpsf1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPSF1 35
  • 99.13 (n)
  • 99.39 (a)
rat
(Rattus norvegicus)
Mammalia Cpsf1 35
  • 87.97 (n)
  • 96.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf1 35
  • 77.32 (n)
  • 82.73 (a)
Str.15765 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398931 35
zebrafish
(Danio rerio)
Actinopterygii cpsf1 35
  • 72.98 (n)
  • 80.01 (a)
wufb24c01 35
cpsf1 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4617 35
fruit fly
(Drosophila melanogaster)
Insecta cpsf 37
  • 45 (a)
Cpsf160 35
  • 52.47 (n)
  • 47.98 (a)
Cpsf160 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011340 35
  • 58.37 (n)
  • 50.94 (a)
worm
(Caenorhabditis elegans)
Secernentea Y76B12C.7 37
  • 31 (a)
cpsf-1 35
  • 44.28 (n)
  • 35.22 (a)
cpsf-1 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT1 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF160 35
  • 44.85 (n)
  • 36.49 (a)
rice
(Oryza sativa)
Liliopsida Os04g0252200 35
  • 44.61 (n)
  • 38.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for CPSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF1 Gene

ENSEMBL:
Gene Tree for CPSF1 (if available)
TreeFam:
Gene Tree for CPSF1 (if available)

Paralogs for CPSF1 Gene

(1) SIMAP similar genes for CPSF1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CPSF1 Gene

genes like me logo Genes that share paralogs with CPSF1: view

No data available for Paralogs for CPSF1 Gene

Variants for CPSF1 Gene

Sequence variations from dbSNP and Humsavar for CPSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs377345879 -- 144,399,555(+) CATGA(A/G)GGGTG intron-variant, upstream-variant-2KB
rs377289569 -- 144,397,668(+) TGGGG(A/G)CCAGC intron-variant
rs377108914 -- 144,398,955(+) CCACA(C/T)ACCTG intron-variant, upstream-variant-2KB
rs377056840 -- 144,399,030(+) GGGCT(A/G)TTCTG reference, synonymous-codon, upstream-variant-2KB
rs377012237 -- 144,399,207(+) CCTGC(A/G)GCACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPSF1 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7963n71 CNV Loss 21882294
dgv7966n71 CNV Loss 21882294
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
nsv891870 CNV Loss 21882294
nsv824805 CNV Gain 20364138
esv2738063 CNV Deletion 23290073
dgv7970n71 CNV Loss 21882294
esv2738064 CNV Deletion 23290073
nsv891873 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294

Relevant External Links for CPSF1 Gene

HapMap Linkage Disequilibrium report
CPSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF1 Gene

Disorders for CPSF1 Gene

(2) Novoseek inferred disease relationships for CPSF1 Gene

Disease -log(P) Hits PubMed IDs
equine infectious anemia 63 1
immunodeficiency 11.7 1
genes like me logo Genes that share disorders with CPSF1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CPSF1 Gene

Publications for CPSF1 Gene

  1. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (PMID: 7590244) Murthy K.G. … Manley J.L. (Genes Dev. 1995) 2 3 4
  2. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 4 23
  3. The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. (PMID: 8654386) Schul W. … de Jong L. (EMBO J. 1996) 3 23
  4. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. (PMID: 19136632) Rozenblatt-Rosen O. … Meyerson M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor. (PMID: 7651824) Jenny A. … Keller W. (Nucleic Acids Res. 1995) 2 3

Products for CPSF1 Gene

Sources for CPSF1 Gene

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