CPSF1 Gene
protein-coding GIFtS: 60
GCID: GC08M145618
|
|
cleavage and polyadenylation specific factor 1, 160kDa(Previous names: cleavage and polyadenylation specific factor 1, 160kD subunit...)
| |
Aliases
for CPSF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cleavage And Polyadenylation Specific Factor 1, 160kDa1 2 | | HSU370122 | | Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit2 3 | | P/Cl.181 | | CPSF1602 3 | | Cleavage And Polyadenylation Specificity Factor Subunit 12 | | CPSF 160 KDa Subunit2 3 | | Polyadenylation Specificity Factor2 | | Cleavage And Polyadenylation Specific Factor 1, 160kD Subunit1 | | |
Export aliases for CPSF1 gene to outside databasesPrevious GC identifers: GC08M143221 GC08M145623 GC08M145223 GC08M145589 GC08M140731 |
Summaries
for CPSF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CPSF1:
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-primeprocessing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins tofacilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy andManley, 1995 (PubMed 7590244)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CPSF1_HUMAN, Q10570Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role inpre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and otherfactors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of thepolyadenylation reaction
Gene Wiki entry for CPSF1
|
Genomic Views
for CPSF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPSF1 gene promoter:
AhR Brachyury NRSF form 1 Lmo2 NRSF form 2 Arnt c-Ets-1 GATA-1 CP2 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPSF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPSF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.23 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24CPSF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M145618: view genomic region
(about GC identifiers)
Start:
|
145,618,444 bp from pter |
End:
|
145,634,753 bp from pter |
Size:
|
16,310 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr8-,PATCHES 145,533,374-145,549,492 |
|
Proteins
for CPSF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPSF1_HUMAN, Q10570 (See
protein sequence)Recommended Name: Cleavage and polyadenylation specificity factor subunit 1 Size: 1443 amino acids; 160884 Da
Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2,CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 andSRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR ofselected pre-mRNAs
Subcellular location: Nucleus, nucleoplasm
Secondary accessions: Q96AF0Explore the universe of human proteins at neXtProt for CPSF1: NX_Q10570
Post-translational modifications:
The N-terminus is blocked1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q10570
CPSF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037423.2
ENSEMBL proteins: ENSP00000339353 ENSP00000435761 Reactome Protein details: Q10570
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- | | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
IDA | -- |
CPSF1 for ontologies About GeneDecksing
CPSF1 Antibody Products:
Assay Products for CPSF1: |
Protein
Domains /
Families
for CPSF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPSF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q10570ProtoNet protein and cluster: Q10570 1 Blocks protein family: IPB004871 CPSF A subunit C-terminal
UniProtKB/Swiss-Prot: CPSF1_HUMAN, Q10570Similarity: Belongs to the CPSF1 family |
Function
for CPSF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CPSF1_HUMAN, Q10570Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role inpre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and otherfactors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of thepolyadenylation reaction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CPSF1 (NM_013291) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CPSF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CPSF1:
|
Pathways & Interactions
for CPSF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase II Transcription Termination | | | 2 | mRNA Splicing - Major Pathway | | | 3 | Post-Elongation Processing of Intronless pre-mRNA | | | 4 | Transport of Mature mRNA Derived from an Intronless Transcript | | | 5 | Transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CPSF1
5/18 
Reactome Pathways for CPSF1 (see all 18)
1 
Kegg Pathway (Kegg details for CPSF1):
CPSF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPSF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/697 Interacting proteins for CPSF1 (Q105702, 3 ENSP000003393534) via UniProtKB, MINT, STRING, and/or I2D (see all 697)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
CPSF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CPSF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CPSF1 for compounds About GeneDecksing
 Browse Tocris compounds for CPSF1
2 Novoseek chemical compound relationships for CPSF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CPSF1
|
Transcripts
for CPSF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPSF1 gene: NM_013291.2 Unigene Cluster for CPSF1: Cleavage and polyadenylation specific factor 1, 160kDa Hs.493202 [show with all ESTs]Unigene Representative Sequence: NM_01329114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531480 ENST00000531727 ENST00000349769(uc011lld.1 uc011llf.1 uc011lle.1 uc003zcj.3 uc003zcl.1)
ENST00000532725 ENST00000526271 ENST00000532935 ENST00000524684 ENST00000529288
ENST00000527827 ENST00000527916 ENST00000533492 ENST00000532560 ENST00000531683(uc003zck.1)
ENST00000531042
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPSF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CPSF1 (NM_013291) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPSF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPSF1 |
Additional cDNA sequence: AB046744.1 AK293601.1 BC009954.2 BC017232.2 BC028197.1 U37012.1 15 DOTS entries: DT.447161 DT.100842072 DT.95154623 DT.117812 DT.95154635 DT.100059385 DT.99973247 DT.95243271 DT.100802272 DT.101973407 DT.75133702 DT.100719573 DT.91762660 DT.86848897 DT.91762651 24/347 AceView cDNA sequences (see all 347): BG774076 BM676692 CA427621 BQ894390 CA424849 AB046744 BI116073 BU860193 BI909433 BI819278 AA463948 BI093192 BE676500 BM563740 AW134799 CD299980 AI814533 BQ183083 AI870798 BM793404 C20753 BM702063 BU152990 BU956015
GeneLoc Exon Structure
5/30 Alternative Splicing Database (ASD) splice patterns (SP) for CPSF1 (see all 30) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25a | · | 25b | · | 25c | · | 25d | · | 25e | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | · | 32c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 33a | · | 33b | ^ | 34 | ^ | 35a | · | 35b | ^ | 36a | · | 36b | · | 36c | ^ | 37a | · | 37b | · | 37c | · | 37d | · | 37e | ^ | 38 | ^ | 39 | ^ | 40a | · | 40b | · | 40c | ^ | 41a | · | 41b | · | 41c | ^ | 42a | · | 42b | ^ | 43 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CPSF1
|
Expression
for CPSF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPSF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCGCAGCG
About this image
See CPSF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPSF1
SOURCE GeneReport for Unigene cluster: Hs.493202
SABiosciences Custom PCR Arrays for CPSF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPSF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPSF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPSF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPSF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPSF1 |
Orthologs
for CPSF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPSF1 gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cpsf11 , 5 |
cleavage and polyadenylation specific factor 11, 5 |
87.65(n)1
96.67(a)1 |
|
15 (36.13 cM)5
942301 NM_053193.21 NP_444423.11
765958095 |
lizard
(Anolis carolinensis) |
Reptilia |
CPSF16 |
-- |
82(a) |
1 ↔ 1 |
GL343636.1(17531-95391) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3989312 |
hypothetical protein LOC398931 |
83.91(n) |
|
BC060475.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb24c012 |
Transcribed sequence with moderate similarity to protein more |
79.52(n) |
|
CK026521.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cpsf3
Cpsf1601 |
mRNA cleavage mRNA binding3
Cleavage and polyadenylation specificity factor 16 more1 |
45(a)3
52.53(n)1
48.01(a)1 |
|
51A43
442501 NM_206111.11 NP_995833.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y76B12C.73
cpsf-11 |
Protein CPSF-11 |
31(a)3
44.13(n)1
34.93(a)1 |
|
IV(2009159-2032997)3
1770031 NM_067756.31 NP_500157.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CFT1(YDR301W)4
CFT11 |
RNA-binding subunit of the mRNA cleavage and polyadenylation more4
Cft1p1 |
38.77(n)1
25.71(a)1 |
|
4(1063352-1067425)4
8518951, 4 NP_010587.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CPSF1601 |
cleavage and polyadenylation specificity factor subunit more |
44.54(n)
36.16(a) |
|
835240 NM_124545.2 NP_199979.2 |
rice
(Oryza sativa) |
Liliopsida |
Os04g02522001 |
hypothetical protein |
44.44(n)
38.1(a) |
|
9266269 NM_001186884.1 NP_001173813.1 |
ENSEMBL Gene Tree for CPSF1 (if available)
TreeFam Gene Tree for CPSF1 (if available) |
Paralogs
for CPSF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPSF1 gene
1 SIMAP similar gene for CPSF1 using alignment to 3 protein entries: CPSF1_HUMAN (see all proteins):P/cl.18
CPSF1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CPSF1
PGOHUM00000246572 PGOHUM00000241293
|
Genomic Variants
for CPSF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPSF1 (145618444 - 145634753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CPSF1
3 CNVs: 4613 3752 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPSF1 |
|
Disorders
/ Diseases
for CPSF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPSF1 for disorders About GeneDecksing
OMIM gene information: 606027
OMIM disorders: --
5  diseases for CPSF1: About MalaCardsprostate cancer influenza immunodeficiency prostatitis
neuronitis
1 disease from the University of Copenhagen DISEASES database for CPSF1:Influenza 2 Novoseek disease relationships for CPSF1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| equine infectious anemia |
63 |
1 |
8756653 (1) |
| immunodeficiency |
11.7 |
1 |
8756653 (1) |
Export disorders for CPSF1 gene to outside databases
|
Publications
for CPSF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPSF1 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with CPSF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (PubMed id 7590244)1, 2, 3 Murthy K.G. and Manley J.L. (1995)
- Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2, 9 Kaufmann I.... Keller W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- SRm160 splicing coactivator promotes transcript 3'-end cleavage. (PubMed id 11739730)1, 2 McCracken S.... Blencowe B.J. (2002)
- Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor. (PubMed id 7651824)1, 3 Jenny A. and Keller W. (1995)
- Assignment of the 160-kDa subunit of cleavage and polyadenylation specificity factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping. (PubMed id 11124521)1, 9 Samiotaki M....Tsiapalis C.M. (2000)
- The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. (PubMed id 19136632)1, 9 Rozenblatt-Rosen O....Meyerson M. (2009)
- Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients. (PubMed id 11992410)1, 9 Maeda Y....Itoh K. (2002)
- The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. (PubMed id 8654386)1, 9 Schul W....de Jong L. (1996)
- Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)
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External Searches for CPSF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CPSF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CPSF1 gene
(According to HUGE)
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Specialized Databases showing CPSF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CPSF1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CPSF1 gene:
Search GeneIP for patents involving CPSF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CPSF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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