Aliases for CPSF1 Gene
- Cleavage And Polyadenylation Specific Factor 1, 160kDa 2 3
- Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 3 4
- CPSF 160 KDa Subunit 3 4
- CPSF160 3 4
- Cleavage And Polyadenylation Specific Factor 1, 160kD Subunit 2
- Cleavage And Polyadenylation Specificity Factor Subunit 1 3
- Polyadenylation Specificity Factor 3
- HSU37012 3
- P/Cl.18 3
External Ids for CPSF1 Gene
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CPSF1 Gene
CPSF1 (Cleavage And Polyadenylation Specific Factor 1, 160kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include mRNA 3-UTR binding.
UniProtKB/Swiss-Prot for CPSF1 Gene
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.