Aliases for CPSF1 Gene
External Ids for CPSF1 Gene
Previous GeneCards Identifiers for CPSF1 Gene
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CPSF1 Gene
CPSF1 (Cleavage And Polyadenylation Specific Factor 1) is a Protein Coding gene. Diseases associated with CPSF1 include Prostate Cancer Susceptibility. Among its related pathways are mRNA surveillance pathway and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding.
UniProtKB/Swiss-Prot for CPSF1 Gene
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.