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Aliases for CPSF1 Gene

Aliases for CPSF1 Gene

  • Cleavage And Polyadenylation Specific Factor 1 2 3 5
  • Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 1, 160kDa 2 3
  • CPSF 160 KDa Subunit 3 4
  • CPSF160 3 4
  • Cleavage And Polyadenylation Specific Factor 1, 160kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 1 3
  • Polyadenylation Specificity Factor 3
  • HSU37012 3
  • P/Cl.18 3

External Ids for CPSF1 Gene

Previous GeneCards Identifiers for CPSF1 Gene

  • GC08M143221
  • GC08M145623
  • GC08M145223
  • GC08M145589
  • GC08M145618
  • GC08M140731

Summaries for CPSF1 Gene

Entrez Gene Summary for CPSF1 Gene

  • Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF1 Gene

CPSF1 (Cleavage And Polyadenylation Specific Factor 1) is a Protein Coding gene. Diseases associated with CPSF1 include Prostate Cancer Susceptibility. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding.

UniProtKB/Swiss-Prot for CPSF1 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Wiki entry for CPSF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF1 Gene

Genomics for CPSF1 Gene

Regulatory Elements for CPSF1 Gene

Enhancers for CPSF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144353 1.3 Ensembl ENCODE 85.7 +52.9 52888 6.7 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 CPSF1 VPS28 TONSL TMEM249 FBXL6 ENSG00000271698
GH08G144372 1.1 ENCODE 96.2 +35.4 35434 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 CBX5 ZNF207 CPSF1 TONSL DGAT1 ADCK5 MIR939
GH08G144386 0.8 ENCODE 99.7 +22.2 22246 1.6 SOX13 PKNOX1 TFAP4 SAP130 FEZF1 ZBTB40 RARA HIC1 ZBTB48 HSF1 CPSF1 VPS28 TONSL-AS1 TONSL DGAT1 ENSG00000254690 HSF1 BOP1 WDR97 SHARPIN
GH08G144401 0.9 ENCODE 78.1 +6.9 6892 1.4 HDAC1 HDGF PKNOX1 ATF1 CBX3 TBL1XR1 ARNT AGO1 TCF12 GATA2 CPSF1 MIR6849
GH08G144363 0.8 ENCODE 72 +46.3 46325 0.2 ELF3 DRAP1 MXI1 SAP130 ARID4B CEBPG HBP1 ZNF48 RARA TEAD3 CPSF1 VPS28 TONSL-AS1 TONSL HSF1 BOP1 FBXL6 LOC101928902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPSF1 on UCSC Golden Path with GeneCards custom track

Promoters for CPSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232243 100 1401 HDGF HNRNPUL1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for CPSF1 Gene

Chromosome:
8
Start:
144,393,229 bp from pter
End:
144,409,400 bp from pter
Size:
16,172 bases
Orientation:
Minus strand

Genomic View for CPSF1 Gene

Genes around CPSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF1 Gene

Proteins for CPSF1 Gene

  • Protein details for CPSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10570-CPSF1_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 1
    Protein Accession:
    Q10570
    Secondary Accessions:
    • Q96AF0

    Protein attributes for CPSF1 Gene

    Size:
    1443 amino acids
    Molecular mass:
    160884 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.

neXtProt entry for CPSF1 Gene

Post-translational modifications for CPSF1 Gene

  • The N-terminus is blocked.
  • Ubiquitination at isoforms=6, Lys52, isoforms=116, Lys364, isoforms=395, Lys809, Lys847, isoforms=1104, isoforms=1118, isoforms=1241, and isoforms=1421
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CPSF1 Gene

Domains & Families for CPSF1 Gene

Protein Domains for CPSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q10570

UniProtKB/Swiss-Prot:

CPSF1_HUMAN :
  • Belongs to the CPSF1 family.
Family:
  • Belongs to the CPSF1 family.
genes like me logo Genes that share domains with CPSF1: view

No data available for Gene Families for CPSF1 Gene

Function for CPSF1 Gene

Molecular function for CPSF1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Ontology (GO) - Molecular Function for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 7590244
GO:0019899 enzyme binding IPI 7590244
GO:0035925 mRNA 3-UTR AU-rich region binding IDA 7590244
genes like me logo Genes that share ontologies with CPSF1: view
genes like me logo Genes that share phenotypes with CPSF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF1 Gene

Localization for CPSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPSF1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 7590244
genes like me logo Genes that share ontologies with CPSF1: view

Pathways & Interactions for CPSF1 Gene

genes like me logo Genes that share pathways with CPSF1: view

Pathways by source for CPSF1 Gene

Gene Ontology (GO) - Biological Process for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IMP 7590244
GO:0006379 mRNA cleavage IBA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
genes like me logo Genes that share ontologies with CPSF1: view

No data available for SIGNOR curated interactions for CPSF1 Gene

Drugs & Compounds for CPSF1 Gene

(1) Drugs for CPSF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CPSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPSF1: view

Transcripts for CPSF1 Gene

Unigene Clusters for CPSF1 Gene

Cleavage and polyadenylation specific factor 1, 160kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28:
SP29:
SP30:

ExUns: 33a · 33b ^ 34 ^ 35a · 35b ^ 36a · 36b · 36c ^ 37a · 37b · 37c · 37d · 37e ^ 38 ^ 39 ^ 40a · 40b · 40c ^ 41a · 41b · 41c ^ 42a · 42b ^ 43
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27:
SP28:
SP29:
SP30:

Relevant External Links for CPSF1 Gene

GeneLoc Exon Structure for
CPSF1
ECgene alternative splicing isoforms for
CPSF1

Expression for CPSF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPSF1 Gene

This gene is overexpressed in Liver, secretome (18.5), Peripheral blood mononuclear cells (9.7), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPSF1 Gene



Protein tissue co-expression partners for CPSF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPSF1 Gene:

CPSF1

SOURCE GeneReport for Unigene cluster for CPSF1 Gene:

Hs.493202

Evidence on tissue expression from TISSUES for CPSF1 Gene

  • Pancreas(4.3)
  • Lung(2.7)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CPSF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF1 Gene

Orthologs for CPSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF1 34
  • 99.13 (n)
oppossum
(Monodelphis domestica)
Mammalia CPSF1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF1 34 35
  • 90.39 (n)
cow
(Bos Taurus)
Mammalia CPSF1 34 35
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Cpsf1 34
  • 87.97 (n)
mouse
(Mus musculus)
Mammalia Cpsf1 34 16 35
  • 87.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF1 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf1 34
  • 77.32 (n)
Str.15765 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398931 34
zebrafish
(Danio rerio)
Actinopterygii cpsf1 34 35
  • 72.98 (n)
wufb24c01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4617 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011340 34
  • 58.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cpsf160 34 35
  • 52.47 (n)
cpsf 36
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea cpsf-1 34 35
  • 44.28 (n)
Y76B12C.7 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT1 35
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF160 34
  • 44.85 (n)
rice
(Oryza sativa)
Liliopsida Os04g0252200 34
  • 44.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for CPSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF1 Gene

ENSEMBL:
Gene Tree for CPSF1 (if available)
TreeFam:
Gene Tree for CPSF1 (if available)

Paralogs for CPSF1 Gene

(1) SIMAP similar genes for CPSF1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CPSF1 Gene

genes like me logo Genes that share paralogs with CPSF1: view

No data available for Paralogs for CPSF1 Gene

Variants for CPSF1 Gene

Sequence variations from dbSNP and Humsavar for CPSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000004491 -- 144,410,450(+) ATATG(A/T)TTGTA upstream-variant-2KB
rs1000079849 -- 144,400,198(+) TGAGG(C/G)TGTTG downstream-variant-500B, upstream-variant-2KB, reference, missense
rs1000327769 -- 144,402,263(+) CCATT(A/G)CCTCA intron-variant, upstream-variant-2KB
rs1001277393 -- 144,405,090(+) AAATC(G/T)GAATA intron-variant
rs1001364441 -- 144,393,113(+) CACCT(C/T)GGGCT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPSF1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2759652 CNV gain+loss 17122850
nsv1124391 CNV deletion 24896259
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612934 CNV loss 21841781
nsv824805 CNV gain 20364138
nsv831489 CNV loss 17160897

Variation tolerance for CPSF1 Gene

Residual Variation Intolerance Score: 1.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF1 Gene

Disorders for CPSF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPSF1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards
Search CPSF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPSF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF1
genes like me logo Genes that share disorders with CPSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPSF1 Gene

Publications for CPSF1 Gene

  1. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 4 22 64
  2. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (PMID: 7590244) Murthy K.G. … Manley J.L. (Genes Dev. 1995) 2 3 4 64
  3. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PMID: 21102410) Laishram R.S. … Anderson R.A. (EMBO J. 2010) 3 4 64
  4. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. (PMID: 19136632) Rozenblatt-Rosen O. … Meyerson M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CPSF1 Gene

Sources for CPSF1 Gene

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