Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPSF1 Gene

Aliases for CPSF1 Gene

  • Cleavage And Polyadenylation Specific Factor 1 2 3 5
  • Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 1, 160kDa 2 3
  • CPSF 160 KDa Subunit 3 4
  • CPSF160 3 4
  • Cleavage And Polyadenylation Specific Factor 1, 160kD Subunit 2
  • Polyadenylation Specificity Factor 3
  • HSU37012 3
  • P/Cl.18 3

External Ids for CPSF1 Gene

Previous GeneCards Identifiers for CPSF1 Gene

  • GC08M143221
  • GC08M145623
  • GC08M145223
  • GC08M145589
  • GC08M145618
  • GC08M140731

Summaries for CPSF1 Gene

Entrez Gene Summary for CPSF1 Gene

  • Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPSF1 Gene

CPSF1 (Cleavage And Polyadenylation Specific Factor 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding.

UniProtKB/Swiss-Prot for CPSF1 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Wiki entry for CPSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF1 Gene

Genomics for CPSF1 Gene

Regulatory Elements for CPSF1 Gene

Promoters for CPSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPSF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPSF1 Gene

Chromosome:
8
Start:
144,393,229 bp from pter
End:
144,409,400 bp from pter
Size:
16,172 bases
Orientation:
Minus strand

Genomic View for CPSF1 Gene

Genes around CPSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF1 Gene

Proteins for CPSF1 Gene

  • Protein details for CPSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10570-CPSF1_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 1
    Protein Accession:
    Q10570
    Secondary Accessions:
    • Q96AF0

    Protein attributes for CPSF1 Gene

    Size:
    1443 amino acids
    Molecular mass:
    160884 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.

neXtProt entry for CPSF1 Gene

Proteomics data for CPSF1 Gene at MOPED

Post-translational modifications for CPSF1 Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys 6, Lys 52, Lys 116, Lys 364, Lys 395, Lys 809, Lys 847, Lys 1104, Lys 1118, Lys 1241, and Lys 1421
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF1 Gene

Antibody Products

No data available for DME Specific Peptides for CPSF1 Gene

Domains & Families for CPSF1 Gene

Protein Domains for CPSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q10570

UniProtKB/Swiss-Prot:

CPSF1_HUMAN :
  • Belongs to the CPSF1 family.
Family:
  • Belongs to the CPSF1 family.
genes like me logo Genes that share domains with CPSF1: view

No data available for Gene Families for CPSF1 Gene

Function for CPSF1 Gene

Molecular function for CPSF1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Ontology (GO) - Molecular Function for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035925 mRNA 3-UTR AU-rich region binding IDA 7590244
genes like me logo Genes that share ontologies with CPSF1: view
genes like me logo Genes that share phenotypes with CPSF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF1 Gene

Localization for CPSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPSF1 Gene COMPARTMENTS Subcellular localization image for CPSF1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CPSF1 Gene

Pathways & Interactions for CPSF1 Gene

genes like me logo Genes that share pathways with CPSF1: view

Gene Ontology (GO) - Biological Process for CPSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006378 mRNA polyadenylation IMP 7590244
GO:0006379 mRNA cleavage IBA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
genes like me logo Genes that share ontologies with CPSF1: view

No data available for SIGNOR curated interactions for CPSF1 Gene

Drugs & Compounds for CPSF1 Gene

(1) Drugs for CPSF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CPSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPSF1: view

Transcripts for CPSF1 Gene

Unigene Clusters for CPSF1 Gene

Cleavage and polyadenylation specific factor 1, 160kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28:
SP29:
SP30:

ExUns: 33a · 33b ^ 34 ^ 35a · 35b ^ 36a · 36b · 36c ^ 37a · 37b · 37c · 37d · 37e ^ 38 ^ 39 ^ 40a · 40b · 40c ^ 41a · 41b · 41c ^ 42a · 42b ^ 43
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27:
SP28:
SP29:
SP30:

Relevant External Links for CPSF1 Gene

GeneLoc Exon Structure for
CPSF1
ECgene alternative splicing isoforms for
CPSF1

Expression for CPSF1 Gene

mRNA expression in normal human tissues for CPSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPSF1 Gene

This gene is overexpressed in Liver, secretome (18.5), Peripheral blood mononuclear cells (9.7), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPSF1 Gene



SOURCE GeneReport for Unigene cluster for CPSF1 Gene Hs.493202

genes like me logo Genes that share expression patterns with CPSF1: view

Protein tissue co-expression partners for CPSF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPSF1 Gene

Orthologs for CPSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF1 35
  • 99.13 (n)
  • 99.39 (a)
cow
(Bos Taurus)
Mammalia CPSF1 36
  • 96 (a)
OneToOne
CPSF1 35
  • 90.12 (n)
  • 96.39 (a)
dog
(Canis familiaris)
Mammalia CPSF1 35
  • 90.39 (n)
  • 96.63 (a)
CPSF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf1 36
  • 97 (a)
OneToOne
Cpsf1 16
Cpsf1 35
  • 87.65 (n)
  • 96.67 (a)
oppossum
(Monodelphis domestica)
Mammalia CPSF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf1 35
  • 87.97 (n)
  • 96.68 (a)
lizard
(Anolis carolinensis)
Reptilia CPSF1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398931 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf1 35
  • 77.32 (n)
  • 82.73 (a)
Str.15765 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4617 35
zebrafish
(Danio rerio)
Actinopterygii cpsf1 35
  • 72.98 (n)
  • 80.01 (a)
wufb24c01 35
cpsf1 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011340 35
  • 58.37 (n)
  • 50.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta cpsf 37
  • 45 (a)
Cpsf160 36
  • 45 (a)
OneToOne
Cpsf160 35
  • 52.47 (n)
  • 47.98 (a)
worm
(Caenorhabditis elegans)
Secernentea cpsf-1 36
  • 32 (a)
OneToOne
Y76B12C.7 37
  • 31 (a)
cpsf-1 35
  • 44.28 (n)
  • 35.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT1 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF160 35
  • 44.85 (n)
  • 36.49 (a)
rice
(Oryza sativa)
Liliopsida Os04g0252200 35
  • 44.61 (n)
  • 38.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for CPSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF1 Gene

ENSEMBL:
Gene Tree for CPSF1 (if available)
TreeFam:
Gene Tree for CPSF1 (if available)

Paralogs for CPSF1 Gene

(1) SIMAP similar genes for CPSF1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CPSF1 Gene

genes like me logo Genes that share paralogs with CPSF1: view

No data available for Paralogs for CPSF1 Gene

Variants for CPSF1 Gene

Sequence variations from dbSNP and Humsavar for CPSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1971250 -- 144,402,400(-) AACCC(A/G)GGAGG intron-variant
rs4317614 -- 144,398,573(+) CGGCC(A/G)TCGTC upstream-variant-2KB, reference, synonymous-codon
rs2280836 -- 144,396,341(-) TGGGG(C/T)CCGGC intron-variant
rs2977841 -- 144,411,235(-) cacac(C/G)tgtga upstream-variant-2KB
rs2977842 -- 144,408,988(-) CTCCC(C/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF1 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7963n71 CNV Loss 21882294
dgv7966n71 CNV Loss 21882294
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
nsv891870 CNV Loss 21882294
nsv824805 CNV Gain 20364138
esv2738063 CNV Deletion 23290073
dgv7970n71 CNV Loss 21882294
esv2738064 CNV Deletion 23290073
nsv891873 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294

Variation tolerance for CPSF1 Gene

Residual Variation Intolerance Score: 1.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPSF1 Gene

HapMap Linkage Disequilibrium report
CPSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF1 Gene

Disorders for CPSF1 Gene

Relevant External Links for CPSF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPSF1

No disorders were found for CPSF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF1 Gene

Publications for CPSF1 Gene

  1. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (PMID: 7590244) Murthy K.G. … Manley J.L. (Genes Dev. 1995) 2 3 4 67
  2. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. (PMID: 19136632) Rozenblatt-Rosen O. … Meyerson M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I. … Keller W. (EMBO J. 2004) 3 23
  4. Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients. (PMID: 11992410) Maeda Y. … Itoh K. (Int. J. Cancer 2002) 3 23
  5. Assignment of the 160-kDa subunit of cleavage and polyadenylation specificity factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping. (PMID: 11124521) Samiotaki M. … Tsiapalis C.M. (Cytogenet. Cell Genet. 2000) 3 23

Products for CPSF1 Gene

Sources for CPSF1 Gene

Back to Top

Content