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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPQ Gene

protein-coding   GIFtS: 46
GCID: GC08P097657

Carboxypeptidase Q

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase Q1 2     LDP2
Lysosomal Dipeptidase1 2 3     aminopeptidase2
Plasma Glutamate Carboxypeptidase1 3     Blood Plasma Glutamate Carboxypeptidase2
Ser-Met Dipeptidase1 2     EC 3.4.17.-3
PGCP2 3     LCH13

External Ids:    HGNC: 169101   Entrez Gene: 104042   Ensembl: ENSG000001043247   UniProtKB: Q9Y6463   

Export aliases for CPQ gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPQ Gene:
This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze
the cleavage of dipeptides with unsubstituted terminals into amino acids. (provided by RefSeq, Jul 2013)

GeneCards Summary for CPQ Gene: 
CPQ (carboxypeptidase Q) is a protein-coding gene. Diseases associated with CPQ include granulocytopenia, and brain cancer. GO annotations related to this gene include metallodipeptidase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: CBPQ_HUMAN, Q9Y646
Function: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes
the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of
thyroxine hormone from its thyroglobulin (Tg) precursor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CPQ
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPQ promoter sequence
   Search SABiosciences Chromatin IP Primers for CPQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.2

CPQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPQ gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P097657:  view genomic region     (about GC identifiers)

Start:
97,657,455 bp from pter      End:
98,161,882 bp from pter
Size:
504,428 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPQ_HUMAN, Q9Y646 (See protein sequence)
Recommended Name: Carboxypeptidase Q precursor  
Size: 472 amino acids; 51888 Da
Subunit: Homodimer. The monomeric form is inactive while the homodimer is active
Subcellular location: Endoplasmic reticulum. Golgi apparatus. Lysosome (By similarity). Secreted. Note=Secretion
is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin (By similarity)
Sequence caution: Sequence=AAD31418.1; Type=Frameshift; Positions=446;
Secondary accessions: B2RD88 Q8NBZ1 Q9UNM8 Q9Y5X6

Explore the universe of human proteins at neXtProt for CPQ: NX_Q9Y646

Explore proteomics data for CPQ at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y646

  • CPQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPQ Protein Expression
    REFSEQ proteins: NP_057218.1  
    ENSEMBL proteins: 
     ENSP00000220763   ENSP00000431024   ENSP00000429146   ENSP00000431114   ENSP00000429934  
     ENSP00000429134  

    Human Recombinant Protein Products for CPQ: 
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    OriGene Protein Over-expression Lysate for CPQ
    OriGene MassSpec for CPQ 
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    Novus Biologicals CPQ Protein
    Novus Biologicals CPQ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10206990
    GO:0005737cytoplasm IDA10206990
    GO:0005764lysosome ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005794Golgi apparatus ISS--

    CPQ for ontologies           About GeneDecksing



    CPQ Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CPQ 

    Assay Products for CPQ: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007484 Peptidase_M28

    Graphical View of Domain Structure for InterPro Entry Q9Y646

    ProtoNet protein and cluster: Q9Y646

    UniProtKB/Swiss-Prot: CBPQ_HUMAN, Q9Y646
    Similarity: Belongs to the peptidase M28 family


    CPQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPQ_HUMAN, Q9Y646
    Function: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes
    the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of
    thyroxine hormone from its thyroglobulin (Tg) precursor
    Induction: Up-regulated in the majority of hepatitis C virus-associated hepatocellular carcinoma

         Enzyme Number (IUBMB): EC 3.4.17.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0016787hydrolase activity ----
    GO:0042803protein homodimerization activity IDA12675526
    GO:0046872metal ion binding IEA--
         
    CPQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPQ:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPQ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPQ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPQ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPQ 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPQ
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    SwitchGear 3'UTR luciferase reporter plasmidCPQ 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPQ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPQ
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                         Customized lentivirus expression plasmids for stable overexpression of CPQ 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPQ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPQ

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CPQ (Q9Y6463 ENSP000002207634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723I2D: score=1 
    SIRT3ENSP000003721914STRING: ENSP00000372191
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA10206990
    GO:0006590thyroid hormone generation ISS--
    GO:0008152metabolic process ----
    GO:0042246tissue regeneration ISS--
    GO:0043171peptide catabolic process IDA10206990

    CPQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPQ for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPQ (CBPQ)

    10/94 Novoseek inferred chemical compound relationships for CPQ gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bestatin 95.6 120 1846352 (3), 18823778 (3), 9355022 (3), 1733647 (3) (see all 80)
    amastatin 88.4 15 1282624 (1), 8395230 (1), 15783133 (1), 7575672 (1) (see all 15)
    probestin 86.6 3 11209758 (1), 9813136 (1), 1417460 (1)
    leuhistin 81.6 1 8820902 (1)
    actinonin 79.7 2 14738154 (1), 9813136 (1)
    alanine-p-nitroanilide 76.2 1 8519802 (1)
    leucine 73.5 49 8860437 (2), 10220586 (2), 14599351 (2), 8444149 (1) (see all 39)
    puromycin 72.1 13 11955816 (2), 9819290 (2), 1680182 (1), 1515063 (1) (see all 11)
    thiorphan 70.2 1 10825373 (1)
    arphamenine b 68.9 2 10374877 (1), 8820902 (1)

    Search CenterWatch for drugs/clinical trials and news about CPQ / CBPQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPQ gene: 
    NM_016134.3  

    Unigene Cluster for CPQ:

    Carboxypeptidase Q
    Hs.156178  [show with all ESTs]
    Unigene Representative Sequence: NM_016134
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220763(uc010mbe.2 uc003yhw.3) ENST00000519900 ENST00000517742
    ENST00000525310 ENST00000519484 ENST00000521142 ENST00000522617 ENST00000532528
    ENST00000529551
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPQ
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPQ
    SwitchGear 3'UTR luciferase reporter plasmidCPQ 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPQ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPQ
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPQ
    Sirion Biotech Customized lentivirus for stable overexpression of CPQ 
                         Customized lentivirus expression plasmids for stable overexpression of CPQ 
    Primer
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    OriGene qPCR primer pairs and template standards for CPQ
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPQ

    Additional mRNA sequence: 

    AF107833.1 AF107834.1 AF119386.1 AK075132.1 AK296013.1 AK304008.1 AK315447.1 BC012019.1 
    BC020689.1 

    12 DOTS entries:

    DT.452074  DT.100795333  DT.91755837  DT.95110180  DT.100795336  DT.100795332  DT.120639329  DT.120639341 
    DT.120639470  DT.91755830  DT.91755846  DT.100645102 

    24/256 AceView cDNA sequences (see all 256):

    CR599327 AI022619 CA445512 BI754468 BC020689 BM503918 AA977851 BX110530 
    BU623880 BM710601 AW069103 R05717 BF445505 AW440965 AI361429 BG190926 
    AA410735 BI909780 BX355940 CA412549 Z41866 BC012019 BQ019250 W88670 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPQ expression in normal human tissues (normalized intensities)      CPQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTGTTA
    CPQ Expression
    About this image


    CPQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Neural Tube (Nervous System)
             Rhombencephalon
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See CPQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPQ

    SOURCE GeneReport for Unigene cluster: Hs.156178

    UniProtKB/Swiss-Prot: CBPQ_HUMAN, Q9Y646
    Tissue specificity: Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in
    muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level)

        SABiosciences Custom PCR Arrays for CPQ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPQ gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpq5
    Pgcp1
    plasma glutamate carboxypeptidase1, 5 87.45(n)1
    88.09(a)1
      15 (13.74 cM)5
    543811  NM_018755.21  NP_061225.21 
     330831295 
    chicken
    (Gallus gallus)
    Aves CPQ1 carboxypeptidase Q 72.57(n)
    74.2(a)
      420238  XM_418350.3  XP_418350.3 
    lizard
    (Anolis carolinensis)
    Reptilia CPQ6
    --
    Uncharacterized protein
    71(a)
    55(a)
    many → 1
    many → 1
    4(20132426-20331338)
    AAWZ02039528(396-1219)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142522 Xenopus laevis transcribed sequence with weak similarity more 70.35(n)    BX850772.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.2242 Oncorhynchus mykiss transcribed sequence with moderate more 74.17(n)    BX319373.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0012641 AGAP001264-PA 54.34(n)
    49.32(a)
      1281913  XM_321888.4  XP_321888.3 


    ENSEMBL Gene Tree for CPQ (if available)
    TreeFam Gene Tree for CPQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8165 SNPs in CPQ are shown (see all 8165)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345390831,2
    C--92889849(+) AAACT-/ATGAAAA 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs30364521,2
    C--93065668(+) TTTTT-/TT/TTT
            
    GCAAG
    1 -- int1 trp31NA 2
    rs58934101,2
    C--93319785(+) ttttt-/TT/TTT
            
    GCCTT
    1 -- int11NA 2
    rs585205631,2
    C--97729414(+) TAAAC-/ATGTGTG 1 -- int10--------
    rs352474691,2
    C--97743095(+) CATAC-/AT/ATACATACA
    TATATATATATATAT
    ATATA
    2 -- int1 cds11NA 2
    rs1138490271,2
    C--97744797(+) TTTTTC/TTTTTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs340589281,2
    C--97774381(+) TAAAA-/GTTTCA 1 -- int10--------
    rs69955301,2
    C,A--97789988(+) tatatA/Tttttt 1 -- int10--------
    rs126758781,2
    H--97789990(+) tatatA/Tttttt 1 -- int1 trp30--------
    rs1858988841,2
    --97812146(+) ACATAA/TCATGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPQ (97657455 - 97907455 bp, first 250kb of CPQ)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CPQ: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPQ
    DNA2.0 Custom Variant and Variant Library Synthesis for CPQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    20/47 diseases for CPQ (see all 47):    About MalaCards
    granulocytopenia    brain cancer    pulmonary sarcoidosis    interstitial lung disease
    cholestasis    choriocarcinoma    sarcoidosis    fibrosarcoma
    vaginitis    periodontal disease    malaria    acute promyelocytic leukemia
    migraine    periodontitis    vascular disease    acute myocardial infarction
    liver disease    myelodysplastic syndromes    myocardial infarction    gingivitis


    CPQ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/39 Novoseek inferred disease relationships for CPQ gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal epithelium 36.3 2 11955816 (1), 19405998 (1)
    choriocarcinoma 32.4 4 14691298 (1), 16364975 (1), 7961121 (1), 8572606 (1)
    alzheimers disease 6.23 10 2230828 (2), 9070837 (1), 9266855 (1), 11295540 (1) (see all 5)
    necrosis 4.14 1 12819930 (1)
    pneumonia 3.28 1 15751279 (1)
    cholestasis 2.85 1 8103033 (1)
    cardiovascular diseases 2.85 1 18373194 (1)
    leukemia promyelocytic acute 2.35 1 16800923 (1)
    carcinoma renal cell 1.53 3 1698011 (2), 17692401 (1)
    breast cancer 1.52 3 16619500 (1), 10508127 (1)


    Export disorders for CPQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPQ gene, integrated from 9 sources (see all 476):
    (articles sorted by number of sources associating them with CPQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl- alpha-glutamate carboxypeptidase/prostate-specific membrane antigen. (PubMed id 10206990)1, 2, 3 Gingras R....Pshezhetsky A.V. (1999)
    2. Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. (PubMed id 12591738)1, 2, 9 Smith M.W.... Katze M.G. (2003)
    3. Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization. (PubMed id 17214548)1, 2 Dolenc I.... Turk V. (2007)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. Purification and primary structure determination of h uman lysosomal dipeptidase. (PubMed id 12675526)1, 2 Dolenc I. and Mihelic M. (2003)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1 Joslyn G....White R.L. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. (PubMed id 20802479)1 Anttila V....Palotie A. (2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10404 HGNC: 16910 AceView: PGCP Ensembl:ENSG00000104324 euGenes: HUgn10404
    ECgene: CPQ H-InvDB: CPQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPQ gene:
    Search GeneIP for patents involving CPQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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