CPPED1 Gene
protein-coding GIFtS: 43
GCID: GC16M012753
|
|
calcineurin-like phosphoesterase domain containing 1
| |
Aliases
for CPPED1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcineurin-Like Phosphoesterase Domain Containing 11 2 | | Calcineurin-Like Phosphoesterase Domain-Containing Protein 12 | | CSTP11 2 3 | | Complete S Transactivated Protein 12 | | Complete S-Transactivated Protein 12 3 | | EC 3.1.-.-3 | | FLJ111511 | | |
Export aliases for CPPED1 gene to outside databasesPrevious GC identifer: GC16M012661 |
Summaries
for CPPED1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CPPED1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPPED1 gene promoter:
AP-1 GCNF HSF1 (long) CUTL1 GATA-1 YY1 GCNF-1 Cart-1 HSF1short GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPPED1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPPED1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.12 Ensembl cytogenetic band: 16p13.12 HGNC cytogenetic band: 16p13.12CPPED1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M012753: view genomic region
(about GC identifiers)
Start:
|
12,753,656 bp from pter |
End:
|
12,897,874 bp from pter |
Size:
|
144,219 bases |
Orientation:
|
minus strand |
|
Proteins
for CPPED1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPPED_HUMAN, Q9BRF8 (See
protein sequence)Recommended Name: Calcineurin-like phosphoesterase domain-containing protein 1 Size: 314 amino acids; 35548 Da
Cofactor: Binds 2 divalent metal cations (By similarity)
Secondary accessions: Q6MZY9 Q9H9M9 Q9NUT6Alternative splicing: 2 isoforms: Q9BRF8-1 Q9BRF8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CPPED1: NX_Q9BRF8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRF8
CPPED1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092925.1 NP_060810.2
ENSEMBL proteins: ENSP00000371193 ENSP00000411127 ENSP00000261660
Human Recombinant Protein Products:
CPPED1 Antibody Products:
Assay Products for CPPED1: |
Protein
Domains /
Families
for CPPED1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPPED1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRF8ProtoNet protein and cluster: Q9BRF8 UniProtKB/Swiss-Prot: CPPED_HUMAN, Q9BRF8Similarity: Belongs to the metallophosphoesterase superfamily. CPPED1 family |
Function
for CPPED1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CPPED_HUMAN, Q9BRF8Induction: Transactivated by the large envelope protein of the hepatitis B virus (HBV)Enzyme Number (IUBMB): EC 3.1.-.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPPED1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CPPED1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPPED1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPPED1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
CPPED1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CPPED1:
|
Pathways & Interactions
for CPPED1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPPED1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CPPED1 (ENSP000002616604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CPPED1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPPED1
Search CenterWatch for drugs/clinical trials and news about CPPED1 / CPPED
|
Transcripts
for CPPED1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPPED1 gene (2 alternative transcripts): NM_001099455.1 NM_018340.2 Unigene Cluster for CPPED1: Calcineurin-like phosphoesterase domain containing 1 Hs.460002 [show with all ESTs]Unigene Representative Sequence: NM_0183404 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381774(uc002dca.4 uc002dcb.4) ENST00000433677 ENST00000261660
ENST00000539677
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPPED1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPPED1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CPPED1 (NM_018340) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPPED1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPPED1 |
Additional cDNA sequence: AK002013.1 AK022710.1 AK093854.1 AK225359.1 AK225617.1 AK298662.1 AY553877.1 BC006289.2 BX640805.1 11 DOTS entries: DT.65285959 DT.120702846 DT.95266095 DT.40222963 DT.100018043 DT.100767750 DT.91966363 DT.100788868 DT.95182613 DT.95296368 DT.99943392 24/178 AceView cDNA sequences (see all 178): AI418628 AA252255 AU280779 CA866553 AU125422 BM927992 AI765628 BM769905 BQ000554 AI803501 CR593411 BQ218836 BX503953 AA234972 CR605457 AI948697 CA866819 AI344600 CB047060 AL575779 AW238832 AA234717 CA430218 AW104642
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CPPED1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CPPED1
|
Expression
for CPPED1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPPED1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAACTGTG
About this image
See CPPED1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPPED1
SOURCE GeneReport for Unigene cluster: Hs.460002
SABiosciences Custom PCR Arrays for CPPED1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPPED1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPPED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPPED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPPED1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPPED1 |
Orthologs
for CPPED1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CPPED1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cpped11 , 5 |
calcineurin-like phosphoesterase domain containing more1, 5 |
81.41(n)1
79.81(a)1 |
|
16 (6.61 cM)5
2239781 NM_146067.31 NP_666179.21
118037215 |
chicken
(Gallus gallus) |
Aves |
CPPED11 |
calcineurin-like phosphoesterase domain containing more |
66.88(n)
70.32(a) |
|
416418 NM_001159982.1 NP_001153454.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CPPED16 |
-- |
68(a) |
1 ↔ 1 |
GL345008.1(11239-11481) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.114442 |
Xenopus laevis transcribed sequence with weak similarity more |
73.05(n) |
|
CB941119.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.167522 |
Transcribed sequence with weak similarity to protein more |
75.48(n) |
|
CK029211.1 |
ENSEMBL Gene Tree for CPPED1 (if available)
TreeFam Gene Tree for CPPED1 (if available) |
Paralogs
for CPPED1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPPED1 gene
CPPED1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CPPED1
PGOHUM00000244431
|
Genomic Variants
for CPPED1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPPED1 (12753656 - 12897874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CPPED1
2 CNVs: 9273 9274 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPPED1 |
|
Disorders
/ Diseases
for CPPED1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPPED1 for disorders About GeneDecksing
4  diseases for CPPED1: About MalaCardsnevus hepatitis b hepatitis malaria
Human Genome Epidemiology (HuGE) Navigator: CPPED1 (1 document)
Export disorders for CPPED1 gene to outside databases
|
Publications
for CPPED1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPPED1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CPPED1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CPPED1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CPPED1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPPED1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CPPED1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CPPED1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CPPED1 gene:
Search GeneIP for patents involving CPPED1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CPPED1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CPPED1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPPED1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPPED1 | | | OriGene Protein Over-expression Lysate for CPPED1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPPED1 | | OriGene 3'-UTR Clone for CPPED1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPPED1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPPED1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CPPED1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPPED1 |
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