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Aliases for CPPED1 Gene

Aliases for CPPED1 Gene

  • Calcineurin Like Phosphoesterase Domain Containing 1 2 3 5
  • Calcineurin-Like Phosphoesterase Domain-Containing Protein 1 3 4
  • Complete S-Transactivated Protein 1 3 4
  • CSTP1 3 4
  • Calcineurin-Like Phosphoesterase Domain Containing 1 2
  • Serine/Threonine-Protein Phosphatase CPPED1 3
  • Complete S Transactivated Protein 1 2
  • EC 3.1.3.16 4

External Ids for CPPED1 Gene

Previous GeneCards Identifiers for CPPED1 Gene

  • GC16M012661

Summaries for CPPED1 Gene

GeneCards Summary for CPPED1 Gene

CPPED1 (Calcineurin Like Phosphoesterase Domain Containing 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot for CPPED1 Gene

  • Protein phosphatase that dephosphorylates AKT family kinase specifically at Ser-473, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPPED1 Gene

Genomics for CPPED1 Gene

Regulatory Elements for CPPED1 Gene

Enhancers for CPPED1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G012757 1.2 Ensembl ENCODE 12 +45.7 45687 1.4 HDAC1 PKNOX1 ATF1 INSM2 FEZF1 YY1 GATA2 ZNF366 CREM EGR2 CPPED1 LOC105371089 LOC105371090
GH16G012609 1.4 Ensembl ENCODE 8.5 +191.6 191581 5.3 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 ENSG00000259899 ENSG00000238685 CPPED1 SNX29 ENSG00000274834
GH16G012799 1.2 ENCODE 9.2 +2.0 1991 5.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NPIPB2 LOC105371084 ENSG00000261560 COX6CP1 ENSG00000261216 SNX29 CPPED1 LOC105371089
GH16G012816 1 Ensembl ENCODE 8.9 -13.0 -13030 1.4 HDAC1 ELF3 CTCF PKNOX1 TAL1 ETV1 CEBPG TCF12 ZNF766 TRIM24 CPPED1 GC16M012842 ENSG00000199474
GH16G012619 0.9 FANTOM5 ENCODE 8.2 +184.4 184366 0.4 NFIC ATF3 NFIB NRF1 JUNB CPPED1 ENSG00000274834 GC16P012625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPPED1 on UCSC Golden Path with GeneCards custom track

Promoters for CPPED1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083551 417 1601 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for CPPED1 Gene

Chromosome:
16
Start:
12,659,799 bp from pter
End:
12,804,017 bp from pter
Size:
144,219 bases
Orientation:
Minus strand

Genomic View for CPPED1 Gene

Genes around CPPED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPPED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPPED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPPED1 Gene

Proteins for CPPED1 Gene

  • Protein details for CPPED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRF8-CPPED_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase CPPED1
    Protein Accession:
    Q9BRF8
    Secondary Accessions:
    • B4DQ68
    • Q6MZY9
    • Q9H9M9
    • Q9NUT6

    Protein attributes for CPPED1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35548 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPPED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPPED1 Gene

Post-translational modifications for CPPED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPPED1 Gene

No data available for DME Specific Peptides for CPPED1 Gene

Domains & Families for CPPED1 Gene

Protein Domains for CPPED1 Gene

Suggested Antigen Peptide Sequences for CPPED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRF8

UniProtKB/Swiss-Prot:

CPPED_HUMAN :
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
Family:
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
genes like me logo Genes that share domains with CPPED1: view

No data available for Gene Families for CPPED1 Gene

Function for CPPED1 Gene

Molecular function for CPPED1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that dephosphorylates AKT family kinase specifically at Ser-473, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
UniProtKB/Swiss-Prot Induction:
Transactivated by the large envelope protein of the hepatitis B virus (HBV).

Enzyme Numbers (IUBMB) for CPPED1 Gene

Gene Ontology (GO) - Molecular Function for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPPED1: view
genes like me logo Genes that share phenotypes with CPPED1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPPED1 Gene

Localization for CPPED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPPED1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPPED1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
lysosome 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with CPPED1: view

Pathways & Interactions for CPPED1 Gene

genes like me logo Genes that share pathways with CPPED1: view

Pathways by source for CPPED1 Gene

3 Reactome pathways for CPPED1 Gene

Interacting Proteins for CPPED1 Gene

Gene Ontology (GO) - Biological Process for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CPPED1: view

No data available for SIGNOR curated interactions for CPPED1 Gene

Drugs & Compounds for CPPED1 Gene

No Compound Related Data Available

Transcripts for CPPED1 Gene

Unigene Clusters for CPPED1 Gene

Calcineurin-like phosphoesterase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPPED1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for CPPED1 Gene

GeneLoc Exon Structure for
CPPED1
ECgene alternative splicing isoforms for
CPPED1

Expression for CPPED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPPED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPPED1 Gene

This gene is overexpressed in Whole Blood (x18.8).

Protein differential expression in normal tissues from HIPED for CPPED1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPPED1 Gene



Protein tissue co-expression partners for CPPED1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPPED1 Gene:

CPPED1

SOURCE GeneReport for Unigene cluster for CPPED1 Gene:

Hs.460002

mRNA Expression by UniProt/SwissProt for CPPED1 Gene:

Q9BRF8-CPPED_HUMAN
Tissue specificity: Expressed in subcutaneous adipose tissue.

Evidence on tissue expression from TISSUES for CPPED1 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Blood(2.9)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with CPPED1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPPED1 Gene

Orthologs for CPPED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPPED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPPED1 34 35
  • 98.73 (n)
cow
(Bos Taurus)
Mammalia CPPED1 34 35
  • 85.49 (n)
dog
(Canis familiaris)
Mammalia CPPED1 34 35
  • 84.88 (n)
rat
(Rattus norvegicus)
Mammalia Cpped1 34
  • 82.91 (n)
mouse
(Mus musculus)
Mammalia Cpped1 34 16 35
  • 81.41 (n)
oppossum
(Monodelphis domestica)
Mammalia CPPED1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPPED1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPPED1 34 35
  • 66.88 (n)
lizard
(Anolis carolinensis)
Reptilia CPPED1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpped1 34
  • 65.91 (n)
Str.265 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11444 34
zebrafish
(Danio rerio)
Actinopterygii cpped1 34 35
  • 63.85 (n)
Dr.16752 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3773 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
Species where no ortholog for CPPED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPPED1 Gene

ENSEMBL:
Gene Tree for CPPED1 (if available)
TreeFam:
Gene Tree for CPPED1 (if available)

Paralogs for CPPED1 Gene

Pseudogenes.org Pseudogenes for CPPED1 Gene

genes like me logo Genes that share paralogs with CPPED1: view

No data available for Paralogs for CPPED1 Gene

Variants for CPPED1 Gene

Sequence variations from dbSNP and Humsavar for CPPED1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000007581 -- 12,702,188(+) GGGCT(A/G)GGGCA intron-variant
rs1000011067 -- 12,756,374(+) ACTAC(G/T)CTGGG intron-variant
rs1000058334 -- 12,743,078(+) AATTC(C/G)AGACT intron-variant
rs1000069912 -- 12,775,150(+) CCCGA(A/G)TTAGC intron-variant
rs1000088702 -- 12,742,820(+) TCATA(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPPED1 Gene

Variant ID Type Subtype PubMed ID
dgv115e55 CNV loss 17911159
dgv2736n100 CNV loss 25217958
dgv479e214 CNV loss 21293372
dgv4911n54 CNV loss 21841781
esv2751549 CNV loss 17911159
esv3582011 CNV loss 25503493
esv3637967 CNV loss 21293372
esv3637968 CNV loss 21293372
esv3637969 CNV loss 21293372
esv3637972 CNV loss 21293372
nsv1043773 CNV loss 25217958
nsv1052802 CNV loss 25217958
nsv1053617 CNV loss 25217958
nsv1070328 CNV deletion 25765185
nsv1108988 CNV deletion 24896259
nsv473518 CNV novel sequence insertion 20440878
nsv525286 CNV loss 19592680
nsv571463 CNV loss 21841781

Variation tolerance for CPPED1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.52; 91.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPPED1 Gene

Human Gene Mutation Database (HGMD)
CPPED1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPPED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPPED1 Gene

Disorders for CPPED1 Gene

Relevant External Links for CPPED1

Genetic Association Database (GAD)
CPPED1
Human Genome Epidemiology (HuGE) Navigator
CPPED1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPPED1

No disorders were found for CPPED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPPED1 Gene

Publications for CPPED1 Gene

  1. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. (PMID: 23939394) Vaittinen M. … Pulkkinen L. (Diabetes 2013) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for CPPED1 Gene

Sources for CPPED1 Gene

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