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Aliases for CPPED1 Gene

Aliases for CPPED1 Gene

  • Calcineurin Like Phosphoesterase Domain Containing 1 2 3
  • Calcineurin-Like Phosphoesterase Domain Containing 1 2 3 5
  • Calcineurin-Like Phosphoesterase Domain-Containing Protein 1 3 4
  • Complete S Transactivated Protein 1 2 3
  • Complete S-Transactivated Protein 1 3 4
  • CSTP1 3 4
  • EC 3.1.3.16 4

External Ids for CPPED1 Gene

Previous GeneCards Identifiers for CPPED1 Gene

  • GC16M012661

Summaries for CPPED1 Gene

GeneCards Summary for CPPED1 Gene

CPPED1 (Calcineurin Like Phosphoesterase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot for CPPED1 Gene

  • Protein phosphatase that dephosphorylates AKT family kinase specifically at Ser-473, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPPED1 Gene

Genomics for CPPED1 Gene

Regulatory Elements for CPPED1 Gene

Enhancers for CPPED1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPPED1 on UCSC Golden Path with GeneCards custom track

Promoters for CPPED1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPPED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPPED1 Gene

Chromosome:
16
Start:
12,659,799 bp from pter
End:
12,804,017 bp from pter
Size:
144,219 bases
Orientation:
Minus strand

Genomic View for CPPED1 Gene

Genes around CPPED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPPED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPPED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPPED1 Gene

Proteins for CPPED1 Gene

  • Protein details for CPPED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRF8-CPPED_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase CPPED1
    Protein Accession:
    Q9BRF8
    Secondary Accessions:
    • B4DQ68
    • Q6MZY9
    • Q9H9M9
    • Q9NUT6

    Protein attributes for CPPED1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35548 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPPED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPPED1 Gene

Proteomics data for CPPED1 Gene at MOPED

Post-translational modifications for CPPED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPPED1 Gene

No data available for DME Specific Peptides for CPPED1 Gene

Domains & Families for CPPED1 Gene

Protein Domains for CPPED1 Gene

Suggested Antigen Peptide Sequences for CPPED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRF8

UniProtKB/Swiss-Prot:

CPPED_HUMAN :
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
Family:
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
genes like me logo Genes that share domains with CPPED1: view

No data available for Gene Families for CPPED1 Gene

Function for CPPED1 Gene

Molecular function for CPPED1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that dephosphorylates AKT family kinase specifically at Ser-473, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
UniProtKB/Swiss-Prot Induction:
Transactivated by the large envelope protein of the hepatitis B virus (HBV).

Enzyme Numbers (IUBMB) for CPPED1 Gene

Gene Ontology (GO) - Molecular Function for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPPED1: view
genes like me logo Genes that share phenotypes with CPPED1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPPED1 Gene

Localization for CPPED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPPED1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPPED1 Gene COMPARTMENTS Subcellular localization image for CPPED1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CPPED1: view

Pathways & Interactions for CPPED1 Gene

SuperPathways for CPPED1 Gene

No Data Available

Interacting Proteins for CPPED1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371193%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000371193 for CPPED1 Gene via STRING

Gene Ontology (GO) - Biological Process for CPPED1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPPED1 Gene

Drugs & Compounds for CPPED1 Gene

No Compound Related Data Available

Transcripts for CPPED1 Gene

Unigene Clusters for CPPED1 Gene

Calcineurin-like phosphoesterase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPPED1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for CPPED1 Gene

GeneLoc Exon Structure for
CPPED1
ECgene alternative splicing isoforms for
CPPED1

Expression for CPPED1 Gene

mRNA expression in normal human tissues for CPPED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPPED1 Gene

This gene is overexpressed in Whole Blood (x18.8).

Protein differential expression in normal tissues from HIPED for CPPED1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPPED1 Gene



SOURCE GeneReport for Unigene cluster for CPPED1 Gene Hs.460002

mRNA Expression by UniProt/SwissProt for CPPED1 Gene

Q9BRF8-CPPED_HUMAN
Tissue specificity: Expressed in subcutaneous adipose tissue.
genes like me logo Genes that share expression patterns with CPPED1: view

Protein tissue co-expression partners for CPPED1 Gene

- Elite partner

Primer Products

Orthologs for CPPED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPPED1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPPED1 35
  • 85.49 (n)
  • 85.19 (a)
CPPED1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPPED1 35
  • 84.88 (n)
  • 83.07 (a)
CPPED1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpped1 35
  • 81.41 (n)
  • 79.81 (a)
Cpped1 16
Cpped1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPPED1 35
  • 98.73 (n)
  • 98.73 (a)
CPPED1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpped1 35
  • 82.91 (n)
  • 81.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CPPED1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPPED1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPPED1 35
  • 66.88 (n)
  • 70.32 (a)
CPPED1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPPED1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpped1 35
  • 65.91 (n)
  • 67.1 (a)
Str.265 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11444 35
zebrafish
(Danio rerio)
Actinopterygii cpped1 35
  • 63.85 (n)
  • 62.66 (a)
Dr.16752 35
cpped1 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3773 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
Species with no ortholog for CPPED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPPED1 Gene

ENSEMBL:
Gene Tree for CPPED1 (if available)
TreeFam:
Gene Tree for CPPED1 (if available)

Paralogs for CPPED1 Gene

Pseudogenes.org Pseudogenes for CPPED1 Gene

genes like me logo Genes that share paralogs with CPPED1: view

No data available for Paralogs for CPPED1 Gene

Variants for CPPED1 Gene

Sequence variations from dbSNP and Humsavar for CPPED1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3748976 - 12,803,721(-) CCTGG(A/C)CGCGT reference, missense
rs3748980 - 12,781,218(-) TCTTC(A/G)TTCTG reference, missense
rs1713480 - 12,665,109(-) TGTCA(A/G)AGTCG reference, missense
rs11645068 - 12,664,962(+) ATCGG(G/T)GAACA reference, missense
rs3891926 -- 12,778,704(-) CAGGG(G/T)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPPED1 Gene

Variant ID Type Subtype PubMed ID
nsv905352 CNV Loss 21882294
dgv115e55 CNV Loss 17911159
nsv525286 CNV Loss 19592680
esv2751549 CNV Loss 17911159

Variation tolerance for CPPED1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.52; 91.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPPED1 Gene

Disorders for CPPED1 Gene

Relevant External Links for CPPED1

Genetic Association Database (GAD)
CPPED1
Human Genome Epidemiology (HuGE) Navigator
CPPED1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPPED1

No disorders were found for CPPED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPPED1 Gene

Publications for CPPED1 Gene

  1. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. (PMID: 23939394) Vaittinen M. … Pulkkinen L. (Diabetes 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CPPED1 Gene

Sources for CPPED1 Gene

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