Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPOX Gene

protein-coding   GIFtS: 61
GCID: GC03M098239

coproporphyrinogen oxidase

(Previous names: coproporphyrinogen oxidase (coproporphyria, harderoporphyria)...)
(Previous symbol: CPO)
 Explore 69 diseases affiliated with
CPOX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPOX    

Aliases
for CPOX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coproporphyrinogen Oxidase1 2     EC 1.3.3.33 8
CPO1 2 3     Coproporphyrinogen Oxidase (Coproporphyria, Harderoporphyria)1
CPX1 2 3     Coproporphyrinogen-III Oxidase, Mitochondrial2
HCP1 2     Coproporphyrinogenase3
Coprogen Oxidase2 3     Coproporphyrinogenase3
COX2 3     

External Ids:    HGNC: 23211   Entrez Gene: 13712   Ensembl: ENSG000000808197   OMIM: 6127325   UniProtKB: P365513   

Export aliases for CPOX gene to outside databases

Previous GC identifers: GC03M099619 GC03M099780 GC03M098298 GC03M095670


Summaries
for CPOX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPOX:
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble
and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of
coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary
coproporphyria (HCP).(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551
Function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of
rings A and B of coproporphyrinogen III

Gene Wiki entry for CPOX (Coproporphyrinogen III oxidase)


Genomic Views
for CPOX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPOX gene promoter:
         HFH-3   GATA-3   YY1   HEN1   AREB6   FOXI1   Max   Msx-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPOX promoter sequence
   Search SABiosciences Chromatin IP Primers for CPOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12   Ensembl cytogenetic band:  3q12.1   HGNC cytogenetic band: 3q12

CPOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPOX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M098239:  view genomic region     (about GC identifiers)

Start:
 98,239,976 bp from pter      End:
 98,312,567 bp from pter
Size:
 72,592 bases      Orientation:
 minus strand

Proteins
for CPOX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551 (See protein sequence)
Recommended Name: Coproporphyrinogen-III oxidase, mitochondrial precursor  
Size: 454 amino acids; 50152 Da
Subunit: Homodimer
Subcellular location: Mitochondrion intermembrane space
Sequence caution: Sequence=BAA04033.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CPOX:
2AEX (3D)    
Secondary accessions: A8K275 Q14060 Q53F08 Q8IZ45 Q96AF3

Explore the universe of human proteins at neXtProt for CPOX: NX_P36551

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36551

    • 4/10 DME Specific Peptides for CPOX (P36551) (see all 10)
     WCDDYFF  RGIGGIF  ARWEYMH  RYVEFNL 

    CPOX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000088.3  
    ENSEMBL proteins: 
     ENSP00000425880   ENSP00000264193   ENSP00000424924  
    Reactome Protein details: P36551
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CPOX 
    GenScript Custom Purified and Recombinant Proteins Services for CPOX
    Novus Biologicals CPOX Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPOX

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005758mitochondrial intermembrane space TAS--


    CPOX for ontologies           About GeneDecksing



    CPOX Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: CPOX
    OriGene Custom Antibody Services for CPOX 
    GenScript Custom Superior Antibodies Services for CPOX
    Novus Biologicals CPOX Antibodies
    Search for Antibodies for CPOX at Abcam  
    Uscn Antibodies for CPOX
    ThermoFisher Antibodies for CPOX

    Assay Products for CPOX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPOX
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CPOX

    Protein Domains /
    Families
    for CPOX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPOX for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001260 Coprogen_oxidase_aer
     IPR018375 Coprogen_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry P36551

    ProtoNet protein and cluster: P36551

    1 Blocks protein family: IPB001260 Coproporphyrinogen III oxidase

    UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551
    Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family


    Function
    for CPOX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551
    Function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of
    rings A and B of coproporphyrinogen III
    Catalytic activity: Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O

    Enzyme Number (IUBMB): EC 1.3.3.31 2

    miRNA
    Products:            		miRTarBase miRNAs that target CPOX:
    hsa-mir-1 (MIRT001374)

    OriGene 3'-UTR Clone: CPOX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPOX
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CPOX (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-130a* hsa-miR-3653 hsa-miR-216b hsa-miR-23c hsa-miR-4282 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: CPOX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPOX (see all 7)
    OriGene shRNA RFP: CPOX
    OriGene siRNA: CPOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPOX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CPOX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CPOX (NM_000097)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPOX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CPOX
    Search LifeMap BioReagents cell lines for CPOX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPOX

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004109coproporphyrinogen oxidase activity TAS--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IDA16176984


    CPOX for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CPOX:
     Cell cycle / mitosis defect  Increased S DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for CPOX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1heme biosynthesis II
    		heme biosynthesis II1.00
    		Metabolism of porphyrins0.50
    		Heme Biosynthesis0.78
    		heme biosynthesis from uroporphyrinogen-III I0.43
    		Heme biosynthesis0.78
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Glucuronidation
    		Porphyrin and chlorophyll metabolism0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for CPOX 
        Heme Biosynthesis
    heme biosynthesis from uroporphyrinogen-III I
    heme biosynthesis II

    3        Reactome Pathways for CPOX
        Metabolism of porphyrins
    Heme biosynthesis
    Metabolism


    2         Kegg Pathways  (Kegg details for CPOX):
        Porphyrin and chlorophyll metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551
    Pathway: Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2
    route): step 1/1


    CPOX for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for CPOX (P365513 ENSP000002641934) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006778porphyrin-containing compound metabolic process TAS--
    GO:0006779porphyrin-containing compound biosynthetic process ----
    GO:0006782protoporphyrinogen IX biosynthetic process IEA--
    GO:0006783heme biosynthetic process TAS--
    GO:0010035response to inorganic substance ----


    CPOX for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPOX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPOX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPOX

    9 HMDB Compounds for CPOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Coproporphyrin III 14643-66-4--
    Coproporphyrinogen III3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,18-tetrapropanoate (see all 9)2624-63-7--
    Formyl-CoAFormyl coenzyme A 13131-49-2--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--
    Protoporphyrin IX3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionate (see all 11)553-12-8--
    Protoporphyrinogen IX5,10,15,20,22,24-hexahydro protoporphyrin IX deriv. (see all 8)7412-77-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/64 Novoseek chemical compound relationships for CPOX gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    harderoporphyrinogen 91.8 2 17242372 (1)
    protoporphyrinogen 86.3 22 12196143 (2), 19339664 (2), 11248690 (1), 8955072 (1) (see all 13)
    coprogen 82.9 5 16460507 (2), 16084099 (1), 11374994 (1), 8286403 (1)
    prostaglandin 74.2 35 10811855 (2), 16140261 (2), 10651981 (1), 17851120 (1) (see all 24)
    porphyrinogen 73.6 2 11909722 (1), 16061377 (1)
    uroporphyrinogen-iii 72 4 19289130 (1), 8949908 (1), 8621830 (1)
    porphyrin 69.6 14 9298818 (1), 16343843 (1), 19447864 (1), 9674964 (1) (see all 9)
    celecoxib 69.1 5 19201774 (2), 20233202 (1), 14762100 (1), 11336575 (1)
    porphobilinogen 68.8 7 8024730 (3), 8949908 (1), 10787385 (1)
    arachidonic acid 66.1 29 15308583 (2), 8153084 (1), 11230753 (1), 16918423 (1) (see all 23)

    Search CenterWatch for drugs/clinical trials and news about CPOX / HEM6 

    Transcripts
    for CPOX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPOX gene: 
    NM_000097.5  

    Unigene Cluster for CPOX:

    Coproporphyrinogen oxidase
    Hs.476982  [show with all ESTs]
    Unigene Representative Sequence: NM_000097
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512905 ENST00000264193(uc003dsx.3) ENST00000510489 ENST00000513674
    ENST00000515041(uc011bgz.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CPOX
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPOX
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CPOX (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-130a* hsa-miR-3653 hsa-miR-216b hsa-miR-23c hsa-miR-4282 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: CPOX 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPOX (see all 7)
    OriGene shRNA RFP: CPOX
    OriGene siRNA: CPOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPOX
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CPOX (NM_000097)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPOX 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPOX
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPOX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPOX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPOX

    Additional cDNA sequence: 

    AK223481.1 AK290140.1 AK299692.1 BC017210.2 BC023551.2 BC023554.2 BX648974.1 D16611.1 
    Z28409.1 

    10 DOTS entries:

    DT.314896  DT.120889704  DT.100785680  DT.100785681  DT.97842703  DT.120889699  DT.91750697  DT.91750696 
    DT.92061291  DT.99969577 

    24/135 AceView cDNA sequences (see all 135):

    AL709894 BQ025229 AV653084 AL043660 NM_000097 BU170210 BU624260 W80532 
    AA700808 N90153 H28785 BF733155 BG107995 BM971248 BF431018 BX494840 
    BM853610 AV646122 BV204432 CK820489 BG498060 BG944756 N46656 BI711615 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CPOX    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                                          -               
    SP2:                                      -     -                                             
    SP3:                                                                                          
    SP4:                    -     -                                                               


    ECgene alternative splicing isoforms for CPOX

    Expression
    for CPOX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTAGGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CPOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPOX

    SOURCE GeneReport for Unigene cluster: Hs.476982
        SABiosciences Custom PCR Arrays for CPOX
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPOX
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPOX
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPOX
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPOX
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPOX

    Orthologs
    for CPOX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CPOX gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cpox1 , 5 coproporphyrinogen oxidase1, 5 83.41(n)1
    81.9(a)1    		   16 (34.80 cM)5
    128921  NM_007757.21  NP_031783.21 
     586702085 
    chicken
    (Gallus gallus)    		 Aves CPOX1 coproporphyrinogen oxidase 73.67(n)
    76.33(a)    		   418377  XM_416596.3  XP_416596.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CPOX6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 3(175006081-175012188)
    zebrafish
    (Danio rerio)    		 Actinopterygii 570498112   -- 79.53(n)   321294  57049811 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Coprox1 Coproporphyrinogen oxidase 60.43(n)
    63.41(a)    		   44701  NM_080038.3  NP_524777.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HEM13(YDR044W)4
    HEM131    		 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) less4
    Hem13p1    		 54.68(n)1
    54.58(a)1    		   4(546642-547628)4
    8516141, 4  NP_010329.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons LIN21 Coproporphyrinogen III oxidase 54.86(n)
    54.76(a)    		   839489  NM_100230.6  NP_171847.4 
    rice
    (Oryza sativa)    		 Liliopsida Os.179192 Oryza sativa (japonica cultivar-group) isolate 23485 coproporphyrinogen III oxidase mRNA, partial cds less 73.97(n)    AK070391.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria hemF6
    		 coproporphyrinogen III oxidase
    		 48(a)
    		 1 ↔ 1
    		 Chromosome(2551247-2552146)


    ENSEMBL Gene Tree for CPOX (if available)
    TreeFam Gene Tree for CPOX (if available) 

    Paralogs
    for CPOX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CPOX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in CPOX are shown (see all 347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219178711,2
    		Cpathogenic95879269(-) GGTCCC/TAGTGC 2 Q * stg10--------
    rs1219178721,2
    		Cpathogenic95881594(-) CATTTC/TTGTTG 2 S F mis10--------
    rs1219178741,2
    		Cpathogenic95883852(-) TTGGTC/GGTGGA 2 R G mis10--------
    rs1219178701,2
    		Cpathogenic95883900(-) CTGTCC/GATTTT 2 H D mis10--------
    rs1219178731,2
    		Cpathogenic95887056(-) CCCATC/TGTGGA 2 R C mis10--------
    rs1219178661,2
    		Cpathogenic95887065(-) GAGAAC/TGGCGG 2 R W mis10--------
    rs1219178681,2
    		Cpathogenic95891213(-) GCACAA/GAGTTT 2 K E mis11Minor allele frequency- G:0.00NA 4550
    rs289316031,2
    		Cpathogenic95891978(-) TTCTAC/TGCCAT 2 R C mis1 ese32Minor allele frequency- T:0.00NA 4
    rs731339221,2
    		C,--95670551(+) ATGTAC/TGAGAT 1 -- ut310--------
    rs729247221,2
    		C,--95670977(+) TTCCAC/TAAAAA 1 -- ut314Minor allele frequency- T:0.06WA CSA EA 241

    HapMap Linkage Disequilibrium report for CPOX (98239976 - 98312567 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CPOX: --
    Human Gene Mutation Database (HGMD): CPOX

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPOX
    DNA2.0 Custom Variant and Variant Library Synthesis for CPOX

    Disorders / Diseases
    for CPOX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPOX for disorders           About GeneDecksing

    OMIM gene information: 612732   
    OMIM disorders: 121300  
    UniProtKB/Swiss-Prot: HEM6_HUMAN, P36551
  • Defects in CPOX are the cause of hereditary coproporphyria (HCP) [MIM:121300]. HCP is an acute hepatic
    • porphyria and an autosomal dominant disease characterized by neuropsychiatric disturbances and skin photosensitivity.
    Biochemically, there is an overexcretion of coproporphyrin III in the urine and in the feces. HCP is clinically
    characterized by attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. The symptoms are
    generally manifested with rapid onset, and can be precipitated by drugs, alcohol, caloric deprivation, infection,
    endocrine factors or stress. A severe variant form is harderoporphyria, which is characterized by earlier onset
    attacks, massive excretion of harderoporphyrin in the feces, and a marked decrease of coproporphyrinogen IX oxidase
    activity

    20/69 diseases for CPOX (see all 69):    About MalaCards
    coproporphyria    hereditary coproporphyria    kearns-sayre syndrome    harderoporphyria
    xeroderma pigmentosum, group a    porphyria cutanea tarda    porphyria    congenital erythropoietic porphyria
    erythropoietic protoporphyria    mitochondrial encephalomyopathy    xeroderma pigmentosum    acute intermittent porphyria
    pre-eclampsia    familial adenomatous polyposis    encephalomyopathy    acute hepatic porphyria
    autosomal dominant disease    melas syndrome    merrf syndrome    peptic ulcer

    5 diseases from the University of Copenhagen DISEASES database for CPOX:
    Hereditary coproporphyria     Variegate porphyria     Acute intermittent porphyria     Erythropoietic protoporphyria
    Porphyria cutanea tarda

    10/44 Novoseek disease relationships for CPOX gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coproporphyria hereditary 96.5 40 7592568 (2), 9843038 (2), 16176984 (2), 8012360 (2) (see all 26)
    porphyria hepatic 84.5 6 9454777 (2), 16159891 (1), 8024730 (1), 7757079 (1) (see all 5)
    coproporphyria 78.2 1 10899392 (1)
    porphyria 74.4 6 16398658 (2), 7592568 (1), 14669009 (1)
    porphyria variegate 68.6 2 14669009 (1)
    mitochondrial encephalomyopathies 65 3 10637838 (2), 8064325 (1)
    porphyria acute intermittent 64.2 3 14669009 (1), 19460837 (1)
    oxidase deficiency 57 2 11929047 (1), 8621830 (1)
    leigh syndrome 56.8 8 19579665 (2), 7502989 (1), 19772191 (1)
    mitochondrial myopathies 52.7 1 10980727 (1)

    Human Genome Epidemiology (HuGE) Navigator: CPOX (2 documents)

    Export disorders for CPOX gene to outside databases

    Publications
    for CPOX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPOX gene, integrated from 9 sources (see all 265):
    (articles sorted by number of sources associating them with CPOX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria. (PubMed id 7757079)1, 2, 3, 9 Lamoril J....Nordmann Y. (1995)
    2. Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria. (PubMed id 7849704)1, 2, 9 Fujita H.... Sassa S. (1994)
    3. Structural basis of hereditary coproporphyria. (PubMed id 16176984)1, 2, 9 Lee D.-S....Raman C.S. (2005)
    4. The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria. (PubMed id 12862310)1, 2, 9 Susa S.... Kato T. (2003)
    5. Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms. (PubMed id 8012360)1, 2, 9 Martasek P.... Grandchamp B. (1994)
    6. Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase. (PubMed id 8159699)1, 2, 9 Martasek P.... Grandchamp B. (1994)
    7. Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update. (PubMed id 9888388)1, 2, 9 Rosipal R.... Deybach J.-C. (1999)
    8. Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria. (PubMed id 12181641)1, 2, 9 Wiman A.... Harper P. (2002)
    9. Molecular cloning, sequencing and expression of cDNA encoding human coproporphyrinogen oxidase. (PubMed id 8286403)1, 2, 9 Taketani S.... Tokunaga R. (1994)
    10. Hereditary coproporphyria: exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene. (PubMed id 9298818)1, 2, 9 Schreiber W.E.... Jamani A. (1997)

    External Searches for CPOX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CPOX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1371 HGNC: 2321 AceView: CPOX Ensembl:ENSG00000080819 euGenes: HUgn1371
    ECgene: CPOX Kegg: 1371 H-InvDB: CPOX

    Other Databases showing CPOX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPOX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPOX Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CPOX

    Intellectual Property
    for CPOX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPOX gene:
    Search GeneIP for patents involving CPOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CPOX gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CPOX   OriGene shRNA RFP for CPOX  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPOX   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPOX  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CPOX   OriGene 3'-UTR Clone for CPOX  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPOX  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CPOX   OriGene Custom Protein Services for CPOX  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPOX
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPOX
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPOX
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPOX
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPOX
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPOX
     GenScript Custom Purified and Recombinant Proteins Services for CPOX GenScript cDNA clones with any tag delivered in your preferred vector for CPOX
     GenScript Custom Assay Services for CPOX GenScript Custom Superior Antibodies Services for CPOX
     GenScript Custom overexpressing Cell Line Services for CPOX CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CPOX promoter
     Search Chromatin IP Primers for CPOX
     RT2 qPCR Primer Assay in human, mouse, rat CPOX
     Search GNC Networks for CPOX
     SABiosciences Custom PCR Arrays for CPOX
     Search Tocris compounds for CPOX
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CPOX antibodies
     CPOX proteins
     Search for Antibodies for CPOX at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CPOX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CPOX Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CPOX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPOX
     SwitchGear 3'UTR luciferase reporter plasmids for CPOX
     SwitchGear Promoter luciferase reporter plasmids for CPOX
     ThermoFisher Antibodies for CPOX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPOX
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CPOX gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4