Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CPO Gene

protein-coding   GIFtS: 48
GCID: GC02P207804

Carboxypeptidase O

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Carboxypeptidase O1 2
Metallocarboxypeptidase C1 2
Metallocarboxypeptidase O1 2
EC 3.4.17.-3
EC 3.4.178

External Ids:    HGNC: 210111   Entrez Gene: 1307492   Ensembl: ENSG000001444107   OMIM: 6095635   UniProtKB: Q8IVL83   

Export aliases for CPO gene to outside databases

Previous GC identifers: GC03M094920 GC03M097601 GC03M099579 GC02P208007 GC02P208008 GC02P207629 GC02P207512 GC02P199655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CPO Gene:
This gene is a member of the metallocarboxypeptidase gene family. (provided by RefSeq, Jan 2011)

GeneCards Summary for CPO Gene:
CPO (carboxypeptidase O) is a protein-coding gene. Diseases associated with CPO include harderoporphyria, and hereditary coproporphyria. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA2.

UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8
Function: Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the CPO gene promoter:
         AML1a   p53   RelA   LCR-F1   NF-E2 p45   GATA-1   C/EBPalpha   Nkx6-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPO promoter sequence
   Search Chromatin IP Primers for CPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q34

CPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPO gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P207804:  view genomic region     (about GC identifiers)

Start:
207,804,278 bp from pter      End:
207,834,198 bp from pter
Size:
29,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8 (See protein sequence)
Recommended Name: Carboxypeptidase O precursor  
Size: 374 amino acids; 42529 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q2M277 Q7RTW7

Explore the universe of human proteins at neXtProt for CPO: NX_Q8IVL8

Explore proteomics data for CPO at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn132, Asn174, Asn187, Asn251
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CPO (Q8IVL8)
     AFCQWFV  GIHAREW  GTDLNRNF 


    See CPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775100.1  
    ENSEMBL proteins: 
     ENSP00000272852  

    CPO Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CPO
    OriGene Protein Over-expression Lysate for CPO
    OriGene MassSpec for CPO
    OriGene Custom Protein Services for CPO
    GenScript Custom Purified and Recombinant Proteins Services for CPO
    Novus Biologicals CPO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPO

    CPO Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CPO
    OriGene Custom Antibody Services for CPO
    Novus Biologicals CPO Antibodies
    Abcam antibodies for CPO
    Cloud-Clone Corp. Antibodies for CPO
    Search ThermoFisher Antibodies for CPO
    LSBio Antibodies in human, mouse, rat for CPO

    CPO Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CPO
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPO
    Cloud-Clone Corp. CLIAs for CPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase O
    Metallocarboxypeptidases

    1 InterPro protein domain:
     IPR000834 Peptidase_M14

    Graphical View of Domain Structure for InterPro Entry Q8IVL8

    ProtoNet protein and cluster: Q8IVL8

    1 Blocks protein domain: IPB000834 Zinc carboxypeptidase A metalloprotease (M14)

    UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8
    Similarity: Belongs to the peptidase M14 family


    CPO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPO_HUMAN, Q8IVL8
    Function: Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity)

         Genatlas biochemistry entry for CPO:
    coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth
    step of porphyrin biosynthesis

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPO for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPO

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPO:
    hsa-mir-335-5p (MIRT019012)

    Block miRNA regulation of human, mouse, rat CPO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CPO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPO
    Predesigned siRNA for gene silencing in human, mouse, rat CPO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPO

    Clone
    Products:
         
    OriGene clones in human, mouse for CPO (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPO (NM_000097)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CPO
    Browse ESI BIO Cell Lines and PureStem Progenitors for CPO 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CBPO_HUMAN, Q8IVL8: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CPO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPO
    Interactions:

        Search GeneGlobe Interaction Network for CPO

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CPO (ENSP000002728524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELA2AENSP000003526394STRING: ENSP00000352639
    CELA2BENSP000003650754STRING: ENSP00000365075
    CELA3BENSP000003383694STRING: ENSP00000338369
    CTRCENSP000003651164STRING: ENSP00000365116
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    CPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPO (CBPO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CPO gene: 
    NM_173077.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000272852(uc002vby.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CPO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPO
    Predesigned siRNA for gene silencing in human, mouse, rat CPO
    Clone
    Products:
         
    OriGene clones in human, mouse for CPO (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPO (NM_000097)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPO
    OriGene qSTAR qPCR primer pairs in human, mouse for CPO
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CPO
      QuantiTect SYBR Green Assays in human, mouse, rat CPO
      QuantiFast Probe-based Assays in human, mouse, rat CPO

    3 AceView cDNA sequences:

    NM_173077 AJ422118 BK000189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CPO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTTCTCT
    CPO Expression
    About this image

    CPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPO Protein Expression
        Custom PCR Arrays for CPO
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CPO
    OriGene qSTAR qPCR primer pairs in human, mouse for CPO
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CPO
    QuantiTect SYBR Green Assays in human, mouse, rat CPO
    QuantiFast Probe-based Assays in human, mouse, rat CPO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CPO gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CPO1 carboxypeptidase O 86.52(n)
    84.49(a)
      609702  XM_005640588.1  XP_005640645.1 
    chicken
    (Gallus gallus)
    Aves CPO1 carboxypeptidase O 66.1(n)
    62.68(a)
      424095  XM_421950.4  XP_421950.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cpo1 carboxypeptidase O 63.28(n)
    61.54(a)
      100145253  NM_001126735.1  NP_001120207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000056301 novel protein similar to vertebrate carboxypeptidase more 57.06(n)
    53.99(a)
      100005630  NM_001145629.1  NP_001139101.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Coprox3
    CG148201
    heme biosynthesis coproporphyrinogen
    oxidase3
    CG148201
    59(a)
    (best of 19)3
    50.23(n)1
    40.62(a)1
      27C73
    387541  NM_139803.31  NP_648060.11 


    ENSEMBL Gene Tree for CPO (if available)
    TreeFam Gene Tree for CPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CPO gene
    CPA22  CPA12  CPB12  CPA62  CPA32  CPA52  CPB22  CPA42  
    8 SIMAP similar genes for CPO using alignment to 1 protein entry:     CBPO_HUMAN:
    CPB1    CPA3    CPB2    CPA4    CPA6    CPA2
    CPA1    CPA5

    CPO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CPO (see all 944)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360124
    A colorectal cancer sample4--see VAR_0360122 K N mis40--------
    rs2018965811,2
    --199655813(+) GGAAA-/TAAAC 
            
    TAAAG
    1 -- int10--------
    rs114181601,2
    C--199658165(+) TCAGG-/A/AA  
            
    AAAAA
    1 -- int1 trp30--------
    rs2021441391,2
    C--199660498(+) AAATA-/TTTTAA 1 -- int10--------
    rs75761091,2
    C,A,H--199660509(+) aaaaaA/TTTTTT 1 -- int16Minor allele frequency- T:0.19NA WA CSA 129
    rs14531631,2
    C,F--199663616(+) CCATTG/ACAAAA 1 -- int14Minor allele frequency- A:0.36NA 144
    rs1462024841,2
    C--199663616(+) CCATT-/GCAAAAA 1 -- int10--------
    rs1146354311,2
    C--199663619(+) TTGCAA/CAAAAA 1 -- int10--------
    rs759861311,2
    C--199664774(+) AACTTC/AAACAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1415679061,2
    C--199670959(+) ATCAT-/CAGCATCA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for CPO (207804278 - 207834198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CPO:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875740CNV Gain21882294
    esv275226CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPO
    DNA2.0 Custom Variant and Variant Library Synthesis for CPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609563    OMIM disorders: --

    10 diseases for CPO:    
    About MalaCards
    harderoporphyria    hereditary coproporphyria    acute hepatic porphyria    porphyria
    breast and colorectal cancer    asthma    hepatitis    multiple myeloma
    myeloma    colorectal cancer


    CPO for disorders           About GeneDecksing

    Genatlas disease: CPO
    coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurological
    disturbances with an overproduction of coproporphyrin,including harderoporphyria

    Genetic Association Database (GAD): CPO

    Export disorders for CPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CPO gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)1, 2, 3 Wei S.... Fricker L.D. (J. Biol. Chem. 2002)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. (PubMed id 21921028)1 Lyons P.J. and Fricker L.D. (J. Biol. Chem. 2011)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 130749 HGNC: 21011 AceView: CPO Ensembl:ENSG00000144410 euGenes: HUgn130749
    ECgene: CPO H-InvDB: CPO

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CPO gene:
    Search GeneIP for patents involving CPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CPO   OriGene RNAi products in human, mouse, rat for CPO  
     OriGene qPCR primer pairs and template standards for CPO   OriGene Protein Over-expression Lysate for CPO  
     OriGene MassSpec something-or-other for CPO   OriGene clones in human, mouse for CPO  
     OriGene qSTAR qPCR primer pairs in human, mouse for CPO   OriGene Purified Protein for CPO  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CPO   OriGene Custom Protein Services for CPO  

     
     
     Block miRNA regulation of human, mouse, rat CPO using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CPO
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPO Predesigned siRNA for gene silencing in human, mouse, rat CPO
     QuantiFast Probe-based Assays in human, mouse, rat CPO QuantiTect SYBR Green Assays in human, mouse, rat CPO
     Custom PCR Arrays for CPO Search Chromatin IP Primers for CPO
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CPO  Search GeneGlobe Interaction Network for CPO
     Regulatory tfbs in CPO promoter
     GenScript Custom Purified and Recombinant Proteins Services for CPO GenScript cDNA clones with any tag delivered in your preferred vector for CPO
     GenScript Custom Assay Services for CPO GenScript Custom overexpressing Cell Line Services for CPO
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CPO (CBPO)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CPO antibodies
     CPO lysates
     Antibodies for CPO
     See all of Abcam's Antibodies, Kits and Proteins for CPO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CPO
     Antibodies for CPO
     ELISAs for CPO
     CLIAs for CPO



     Browse ESI BIO Cell Lines and PureStem Progenitors for CPO
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CPO
     SwitchGear Promoter luciferase reporter plasmids for CPO
     Search ThermoFisher Antibodies for CPO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPO
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPO
     LSBio Antibodies in human, mouse, rat for CPO
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CPO gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4