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Aliases for CPO Gene

Aliases for CPO Gene

  • Carboxypeptidase O 2 3 5
  • Metallocarboxypeptidase O 2
  • Metallocarboxypeptidase C 2
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPO Gene

Previous GeneCards Identifiers for CPO Gene

  • GC03M094920
  • GC03M097601
  • GC03M099579
  • GC02P208007
  • GC02P208008
  • GC02P207629
  • GC02P207512
  • GC02P207804
  • GC02P199655

Summaries for CPO Gene

Entrez Gene Summary for CPO Gene

  • This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]

GeneCards Summary for CPO Gene

CPO (Carboxypeptidase O) is a Protein Coding gene. Diseases associated with CPO include Coproporphyria. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPO Gene

  • Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPO Gene

Genomics for CPO Gene

Regulatory Elements for CPO Gene

Enhancers for CPO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPO on UCSC Golden Path with GeneCards custom track

Genomic Location for CPO Gene

206,879,383 bp from pter
206,971,064 bp from pter
91,682 bases
Plus strand

Genomic View for CPO Gene

Genes around CPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPO Gene

Proteins for CPO Gene

  • Protein details for CPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase O
    Protein Accession:
    Secondary Accessions:
    • Q2M277
    • Q7RTW7

    Protein attributes for CPO Gene

    374 amino acids
    Molecular mass:
    42529 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPO Gene

Proteomics data for CPO Gene at MOPED

Selected DME Specific Peptides for CPO Gene

Post-translational modifications for CPO Gene

  • Glycosylation at Asn 132, Asn 174, Asn 187, and Asn 251
  • Modification sites at PhosphoSitePlus

Other Protein References for CPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPO Gene

Gene Families for CPO Gene

Protein Domains for CPO Gene

Suggested Antigen Peptide Sequences for CPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPO: view

Function for CPO Gene

Molecular function for CPO Gene

GENATLAS Biochemistry:
coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth step of porphyrin biosynthesis
UniProtKB/Swiss-Prot Function:
Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues.

Enzyme Numbers (IUBMB) for CPO Gene

genes like me logo Genes that share phenotypes with CPO: view

Animal Model Products

CRISPR Products

miRNA for CPO Gene

miRTarBase miRNAs that target CPO

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPO Gene

Localization for CPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPO Gene


Subcellular locations from

Jensen Localization Image for CPO Gene COMPARTMENTS Subcellular localization image for CPO gene
Compartment Confidence
extracellular 4
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CPO Gene

Pathways & Interactions for CPO Gene

SuperPathways for CPO Gene

No Data Available

Interacting Proteins for CPO Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000272852 for CPO Gene via STRING

Gene Ontology (GO) - Biological Process for CPO Gene


No data available for Pathways by source and SIGNOR curated interactions for CPO Gene

Drugs & Compounds for CPO Gene

(9) Drugs for CPO Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Furosemide Approved Pharma Agonist GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 177
Isosorbide Dinitrate Approved Pharma 57
Nitric Oxide Approved Pharma 576
diuretics Pharma 1307
Isosorbide Pharma 57
genes like me logo Genes that share compounds with CPO: view

Transcripts for CPO Gene

mRNA/cDNA for CPO Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPO Gene

Carboxypeptidase O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPO Gene

No ASD Table

Relevant External Links for CPO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPO Gene

mRNA expression in normal human tissues for CPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPO Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.4).

SOURCE GeneReport for Unigene cluster for CPO Gene Hs.684103

genes like me logo Genes that share expression patterns with CPO: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CPO Gene

Orthologs for CPO Gene

This gene was present in the common ancestor of animals.

Orthologs for CPO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPO 35
  • 85.74 (n)
  • 85.03 (a)
CPO 36
  • 85 (a)
(Canis familiaris)
Mammalia CPO 35
  • 86.52 (n)
  • 84.49 (a)
CPO 36
  • 83 (a)
(Pan troglodytes)
Mammalia CPO 35
  • 99.47 (n)
  • 98.66 (a)
CPO 36
  • 99 (a)
(Monodelphis domestica)
Mammalia CPO 36
  • 69 (a)
(Gallus gallus)
Aves CPO 35
  • 66.1 (n)
  • 62.68 (a)
CPO 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpo 35
  • 63.28 (n)
  • 61.54 (a)
(Danio rerio)
Actinopterygii LOC100005630 35
  • 57.06 (n)
  • 53.99 (a)
cpo 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 32 (a)
CG14820 37
  • 36 (a)
CG15769 37
  • 30 (a)
CG17633 37
  • 36 (a)
CG18415 37
  • 31 (a)
CG18417 37
  • 35 (a)
CG18585 37
  • 38 (a)
CG2915 37
  • 36 (a)
CG3097 37
  • 40 (a)
CG3108 37
  • 37 (a)
CG4017 37
  • 38 (a)
CG4408 37
  • 33 (a)
CG7025 37
  • 39 (a)
CG8539 37
  • 29 (a)
CG8560 37
  • 35 (a)
CG8562 37
  • 34 (a)
CG8563 37
  • 34 (a)
CG8945 37
  • 29 (a)
Coprox 37
  • 59 (a)
CG14820 35
  • 50.23 (n)
  • 40.62 (a)
(Caenorhabditis elegans)
Secernentea R11A5.7 37
  • 36 (a)
T06A4.3 37
  • 34 (a)
W01A8.6 37
  • 31 (a)
Y59C2A.1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
CSA.4459 36
  • 28 (a)
Species with no ortholog for CPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPO Gene

Gene Tree for CPO (if available)
Gene Tree for CPO (if available)

Paralogs for CPO Gene

Paralogs for CPO Gene

(8) SIMAP similar genes for CPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPO: view

Variants for CPO Gene

Sequence variations from dbSNP and Humsavar for CPO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13420911 - 206,955,552(+) CCCAT(A/G)TATTA reference, missense
rs11903403 - 206,959,660(+) TCAAG(G/T)ATACG reference, missense
VAR_036012 A colorectal cancer sample
rs730974 -- 206,934,798(+) CTCCA(C/T)CTCTA intron-variant
rs1597916 -- 206,947,000(+) AGGAA(C/G)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPO Gene

Variant ID Type Subtype PubMed ID
nsv875740 CNV Gain 21882294
esv275226 CNV Gain+Loss 21479260

Variation tolerance for CPO Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.46; 96.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPO Gene

Disorders for CPO Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPO Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • harderoporphyria
- elite association - COSMIC cancer census association via MalaCards
Search CPO in MalaCards View complete list of genes associated with diseases

Genatlas disease for CPO Gene

coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurological disturbances with an overproduction of coproporphyrin,including harderoporphyria

Relevant External Links for CPO

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPO: view

No data available for UniProtKB/Swiss-Prot for CPO Gene

Publications for CPO Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S. … Fricker L.D. (J. Biol. Chem. 2002) 2 3 4 67
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  3. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. (PMID: 21921028) Lyons P.J. … Fricker L.D. (J. Biol. Chem. 2011) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CPO Gene

Sources for CPO Gene