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Aliases for CPO Gene

Aliases for CPO Gene

  • Carboxypeptidase O 2 3 5
  • Metallocarboxypeptidase O 2
  • Metallocarboxypeptidase C 2
  • EC 3.4.17.- 4
  • EC 3.4.17 61

External Ids for CPO Gene

Previous GeneCards Identifiers for CPO Gene

  • GC03M094920
  • GC03M097601
  • GC03M099579
  • GC02P208007
  • GC02P208008
  • GC02P207629
  • GC02P207512
  • GC02P207804
  • GC02P199655

Summaries for CPO Gene

Entrez Gene Summary for CPO Gene

  • This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]

GeneCards Summary for CPO Gene

CPO (Carboxypeptidase O) is a Protein Coding gene. Diseases associated with CPO include Coproporphyria. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPB1.

UniProtKB/Swiss-Prot for CPO Gene

  • Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPO Gene

Genomics for CPO Gene

Regulatory Elements for CPO Gene

Enhancers for CPO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G206914 1 Ensembl ENCODE 12.2 +36.0 35971 1.0 MAX THRB FOSL1 GATA2 FOS TFE3 L3MBTL2 NRF1 FOXA3 BHLHE40 CPO PIR53902
GH02G207007 1 Ensembl ENCODE 10.2 +129.0 129017 2.5 CTCF ZBTB21 JUN TEAD4 MAX RBBP5 ARID3A POLR2A NFE2 RELB CPO MIR2355 PIR53902
GH02G206804 0.9 FANTOM5 ENCODE 10.2 -74.8 -74755 0.6 MTA2 ZNF10 BHLHE40 BACH1 REST ZNF316 RAD51 POLR2A NBN MLLT1 DYTN CPO MDH1B ENSG00000223725 ENSG00000260171 MIR3130-1
GH02G206800 0.9 Ensembl ENCODE 10.2 -78.5 -78487 1.0 ELF3 CTCF ZNF654 TRIM22 REST BMI1 EP300 RAD21 SMARCA4 SMC3 MDH1B DYTN CPO MIR3130-1 ENSG00000260171
GH02G206981 0.6 ENCODE 10.9 +102.5 102529 0.2 CTCF ZNF654 REST ZNF2 EP300 RAD21 SMARCA4 SMC3 KDM1A CPO PIR53902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPO on UCSC Golden Path with GeneCards custom track

Genomic Location for CPO Gene

Chromosome:
2
Start:
206,879,383 bp from pter
End:
206,971,064 bp from pter
Size:
91,682 bases
Orientation:
Plus strand

Genomic View for CPO Gene

Genes around CPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPO Gene

Proteins for CPO Gene

  • Protein details for CPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVL8-CBPO_HUMAN
    Recommended name:
    Carboxypeptidase O
    Protein Accession:
    Q8IVL8
    Secondary Accessions:
    • Q2M277
    • Q7RTW7

    Protein attributes for CPO Gene

    Size:
    374 amino acids
    Molecular mass:
    42529 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPO Gene

Selected DME Specific Peptides for CPO Gene

Q8IVL8:
  • AFCQWFV
  • GTDLNRNF
  • GIHAREW

Post-translational modifications for CPO Gene

  • N-glycosylated.
  • Glycosylation at isoforms=132, isoforms=174, Asn187, and isoforms=251
  • Modification sites at PhosphoSitePlus

Other Protein References for CPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPO Gene

Gene Families for CPO Gene

Protein Domains for CPO Gene

Suggested Antigen Peptide Sequences for CPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVL8

UniProtKB/Swiss-Prot:

CBPO_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPO: view

Function for CPO Gene

Molecular function for CPO Gene

GENATLAS Biochemistry:
coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth step of porphyrin biosynthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=325 uM for 3-(2-furyl)acryloyl-Glu-Glu (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=284 uM for 3-(2-furyl)acryloyl-Phe-Phe (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=549 uM for 3-(2-furyl)acryloyl-Phe-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=614 uM for 3-(2-furyl)acryloyl-Lys-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028};
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by potato carboxypeptidase inhibitor, and the chelating agents EDTA and 1,10-phenanthroline. Also inhibited by compounds with multiple carboxylic acid groups such as citrate and succinate, and to a lesser exent the amino acids aspartate and glutamate. Not significantly inhibited by benzylsuccinic acid.
UniProtKB/Swiss-Prot Function:
Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

Enzyme Numbers (IUBMB) for CPO Gene

Gene Ontology (GO) - Molecular Function for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IDA 21921028
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPO: view
genes like me logo Genes that share phenotypes with CPO: view

Animal Model Products

CRISPR Products

miRNA for CPO Gene

miRTarBase miRNAs that target CPO

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPO Gene

Localization for CPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPO Gene

Apical cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPO gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CPO: view

Pathways & Interactions for CPO Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPO: view

No data available for Pathways by source and SIGNOR curated interactions for CPO Gene

Drugs & Compounds for CPO Gene

No Compound Related Data Available

Transcripts for CPO Gene

mRNA/cDNA for CPO Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPO Gene

Carboxypeptidase O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPO Gene

No ASD Table

Relevant External Links for CPO Gene

GeneLoc Exon Structure for
CPO
ECgene alternative splicing isoforms for
CPO

Expression for CPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPO Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.4).

NURSA nuclear receptor signaling pathways regulating expression of CPO Gene:

CPO

SOURCE GeneReport for Unigene cluster for CPO Gene:

Hs.684103

mRNA Expression by UniProt/SwissProt for CPO Gene:

Q8IVL8-CBPO_HUMAN
Tissue specificity: Detected in enterocytes of the ileum.
genes like me logo Genes that share expression patterns with CPO: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPO Gene

Orthologs for CPO Gene

This gene was present in the common ancestor of animals.

Orthologs for CPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPO 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia CPO 34 35
  • 86.52 (n)
cow
(Bos Taurus)
Mammalia CPO 34 35
  • 85.74 (n)
oppossum
(Monodelphis domestica)
Mammalia CPO 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPO 34 35
  • 66.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpo 34
  • 63.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100005630 34
  • 57.06 (n)
cpo 35
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Coprox 36
  • 59 (a)
CG14820 36 34
  • 50.23 (n)
CG3097 36
  • 40 (a)
CG7025 36
  • 39 (a)
CG18585 36
  • 38 (a)
CG4017 36
  • 38 (a)
CG3108 36
  • 37 (a)
CG17633 36
  • 36 (a)
CG2915 36
  • 36 (a)
CG18417 36
  • 35 (a)
CG8560 36
  • 35 (a)
CG8562 36
  • 34 (a)
CG8563 36
  • 34 (a)
CG4408 36
  • 33 (a)
CG12374 36
  • 32 (a)
CG18415 36
  • 31 (a)
CG15769 36
  • 30 (a)
CG8539 36
  • 29 (a)
CG8945 36
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea R11A5.7 36
  • 36 (a)
T06A4.3 36
  • 34 (a)
Y59C2A.1 36
  • 32 (a)
W01A8.6 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
ManyToMany
CSA.4459 35
  • 28 (a)
ManyToMany
Species where no ortholog for CPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPO Gene

ENSEMBL:
Gene Tree for CPO (if available)
TreeFam:
Gene Tree for CPO (if available)

Paralogs for CPO Gene

Paralogs for CPO Gene

(8) SIMAP similar genes for CPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPO: view

Variants for CPO Gene

Sequence variations from dbSNP and Humsavar for CPO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_036012 A colorectal cancer sample
rs1000025355 -- 206,969,945(+) CGGGT(C/G)CTTTT downstream-variant-500B, utr-variant-3-prime
rs1000190743 -- 206,930,997(+) TATCA(C/T)TGATA upstream-variant-2KB
rs1000230162 -- 206,951,678(+) GTTCA(C/T)ACATG intron-variant
rs1000233750 -- 206,931,386(+) AAAAA(-/AAAAAC)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPO Gene

Variant ID Type Subtype PubMed ID
esv275226 CNV gain+loss 21479260
nsv1011347 CNV gain 25217958

Variation tolerance for CPO Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.46; 96.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPO Gene

Disorders for CPO Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPO Gene - From: GeneCards

Disorder Aliases PubMed IDs
coproporphyria
  • harderoporphyria
- elite association - COSMIC cancer census association via MalaCards
Search CPO in MalaCards View complete list of genes associated with diseases

Genatlas disease for CPO Gene

coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurological disturbances with an overproduction of coproporphyrin,including harderoporphyria

Relevant External Links for CPO

Genetic Association Database (GAD)
CPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPO
genes like me logo Genes that share disorders with CPO: view

No data available for UniProtKB/Swiss-Prot for CPO Gene

Publications for CPO Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S. … Fricker L.D. (J. Biol. Chem. 2002) 2 3 4 64
  2. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. (PMID: 21921028) Lyons P.J. … Fricker L.D. (J. Biol. Chem. 2011) 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64

Products for CPO Gene

Sources for CPO Gene

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