CPO Gene
protein-coding GIFtS: 45
GCID: GC02P207804
|
|
carboxypeptidase O
| |
Aliases
for CPO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carboxypeptidase O1 2 | | Metallocarboxypeptidase C2 | | Metallocarboxypeptidase O2 | | EC 3.4.17.-3 | | EC 3.4.178 |
Export aliases for CPO gene to outside databasesPrevious GC identifers: GC03M094920 GC03M097601 GC03M099579 GC02P208007 GC02P208008 GC02P207629 GC02P207512 GC02P199655 |
Summaries
for CPO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CPO:
This gene is a member of the metallocarboxypeptidase gene family. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8Function: Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity)
|
Genomic Views
for CPO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPO gene promoter:
AML1a p53 RelA LCR-F1 NF-E2 p45 GATA-1 C/EBPalpha Nkx6-1 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q34CPO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P207804: view genomic region
(about GC identifiers)
Start:
|
207,804,278 bp from pter |
End:
|
207,834,198 bp from pter |
Size:
|
29,921 bases |
Orientation:
|
plus strand |
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Proteins
for CPO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8 (See
protein sequence)Recommended Name: Carboxypeptidase O precursor Size: 374 amino acids; 42529 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (Potential)
Secondary accessions: Q2M277 Q7RTW7Explore the universe of human proteins at neXtProt for CPO: NX_Q8IVL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVL8
3 DME Specific Peptides for CPO (Q8IVL8)
CPO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775100.1
ENSEMBL proteins: ENSP00000272852
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CPO for ontologies About GeneDecksing
CPO Antibody Products:
Assay Products for CPO: |
Protein
Domains /
Families
for CPO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPO for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IVL8ProtoNet protein and cluster: Q8IVL8 1 Blocks protein family: IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8Similarity: Belongs to the peptidase M14 family |
Function
for CPO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CBPO_HUMAN, Q8IVL8Function: Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity) Genatlas biochemistry entry for CPO:coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth step ofporphyrin biosynthesis
Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPO
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CPO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004181 | metallocarboxypeptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
CPO for ontologies About GeneDecksing
|
Pathways & Interactions
for CPO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPO
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
CPO for ontologies About GeneDecksing
|
Drugs & Compounds
for CPO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPO
Search CenterWatch for drugs/clinical trials and news about CPO / CBPO
|
Transcripts
for CPO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPO gene: NM_173077.2 Unigene Cluster for CPO: Carboxypeptidase O Hs.684103 Unigene Representative Sequence: BC1120781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000272852(uc002vby.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPO
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CPO (NM_000097) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO |
Additional cDNA sequence: AJ422118.1 BC112076.1 BC112078.1 1 DOTS entry: DT.99997833 3 AceView cDNA sequences: BK000189 NM_173077 AJ422118
GeneLoc Exon Structure
|
Expression
for CPO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTTCTCT
About this image
See CPO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPO
SOURCE GeneReport for Unigene cluster: Hs.684103
SABiosciences Custom PCR Arrays for CPO
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CPO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO |
Orthologs
for CPO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CPO gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CPO1 |
carboxypeptidase O |
66.47(n)
63.37(a) |
|
424095 XM_421950.3 XP_421950.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1000056301 |
novel protein similar to vertebrate carboxypeptidase more |
57.06(n)
53.99(a) |
|
100005630 NM_001145629.1 NP_001139101.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Coprox3
CG148201 |
heme biosynthesis coproporphyrinogen oxidase3
CG148201 |
59(a)
(best of 19)3
48.27(n)1
38.64(a)1 |
|
27C73
387541 NM_139803.21 NP_648060.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
R11A5.73 |
zinc carboxypeptidase |
36(a)
(best of 4) |
|
I(7880326-7883577) -- |
ENSEMBL Gene Tree for CPO (if available)
TreeFam Gene Tree for CPO (if available) |
Paralogs
for CPO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPO gene
- CPA22 CPA12 CPB12 CPA62 CPA32 CPA52 CPB22 CPA42
8 SIMAP similar genes for CPO using alignment to 1 protein entry: CBPO_HUMAN:CPB1 CPA3 CPB2 CPA4 CPA6 CPA2
CPA1 CPA5
CPO for paralogs About GeneDecksing
|
Genomic Variants
for CPO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPO (207804278 - 207834198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CPO: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPO |
|
Disorders
/ Diseases
for CPO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPO for disorders About GeneDecksing
OMIM gene information: 609563
OMIM disorders: --
7  diseases for CPO: About MalaCardsharderoporphyria acute hepatic porphyria coproporphyria porphyria
hermaphroditism hepatitis pancreatitis
Genatlas disease: CPO coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurologicaldisturbances with an overproduction of coproporphyrin,including harderoporphyria
Export disorders for CPO gene to outside databases
|
Publications
for CPO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPO gene integrated from 9 sources:
(articles sorted by number of sources associating them with CPO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)1, 2, 3 Wei S.... Fricker L.D. (2002)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Carboxypeptidase O is a glycosylphosphatidylinositol- anchored intestinal peptidase with acidic amino acid specificity. (PubMed id 21921028)1 Lyons P.J. and Fricker L.D. (2011)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CPO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CPO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPO gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CPO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CPO | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CPO gene:
Search GeneIP for patents involving CPO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CPO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CPO | | OriGene shRNA RFP for CPO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPO | | | OriGene Protein Over-expression Lysate for CPO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPO | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CPO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CPO | | OriGene Custom Protein Services for CPO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPO |
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| |  |  |  |  | | | | |
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 | | | CPO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPO |
|  |  |  | | | | Search ThermoFisher Antibodies for CPO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPO |
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