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Aliases for CPNE9 Gene

Aliases for CPNE9 Gene

  • Copine Family Member IX 2 3
  • Copine IX 3 4
  • Copine-Like Protein 3
  • Copine-9 3

External Ids for CPNE9 Gene

Summaries for CPNE9 Gene

GeneCards Summary for CPNE9 Gene

CPNE9 (Copine Family Member IX) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE9 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE9 Gene

Genomics for CPNE9 Gene

Genomic Location for CPNE9 Gene

9,703,807 bp from pter
9,729,908 bp from pter
26,102 bases
Plus strand

Genomic View for CPNE9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE9 Gene

Regulatory Elements for CPNE9 Gene

Proteins for CPNE9 Gene

  • Protein details for CPNE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L430
    • A6NDX6
    • A8MSP8

    Protein attributes for CPNE9 Gene

    553 amino acids
    Molecular mass:
    61864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE9 Gene


neXtProt entry for CPNE9 Gene

Proteomics data for CPNE9 Gene at MOPED

Post-translational modifications for CPNE9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn95

Other Protein References for CPNE9 Gene

No data available for DME Specific Peptides for CPNE9 Gene

Domains for CPNE9 Gene

Protein Domains for CPNE9 Gene



  • Contains 2 C2 domains.:
    • Q8IYJ1
  • Contains 1 VWFA domain.:
    • Q8IYJ1
  • Belongs to the copine family.:
    • Q8IYJ1
genes like me logo Genes that share domains with CPNE9: view

No data available for Gene Families for CPNE9 Gene

Function for CPNE9 Gene

Molecular function for CPNE9 Gene

UniProtKB/Swiss-Prot Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

Gene Ontology (GO) - Molecular Function for CPNE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CPNE9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPNE9 Gene

Localization for CPNE9 Gene

Subcellular locations from

Jensen Localization Image for CPNE9 Gene COMPARTMENTS Subcellular localization image for CPNE9 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPNE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE9: view

Pathways for CPNE9 Gene

SuperPathways for CPNE9 Gene

No Data Available

Interacting Proteins for CPNE9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373343 for CPNE9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CPNE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903861 positive regulation of dendrite extension IDA 23999003
genes like me logo Genes that share ontologies with CPNE9: view

No data available for Pathways by source for CPNE9 Gene

Compounds for CPNE9 Gene

(1) HMDB Compounds for CPNE9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CPNE9: view

Transcripts for CPNE9 Gene

Unigene Clusters for CPNE9 Gene

Copine family member IX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3: -

Relevant External Links for CPNE9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE9 Gene

mRNA expression in normal human tissues for CPNE9 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE9 Gene

This gene is overexpressed in Brain - Cerebellum (9.8), Brain - Cerebellar Hemisphere (9.2), Brain - Cortex (9.0), Brain - Frontal Cortex (BA9) (6.7), and Brain - Anterior cingulate cortex (BA24) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE9 Gene

SOURCE GeneReport for Unigene cluster for CPNE9 Gene Hs.121335

genes like me logo Genes that share expressions with CPNE9: view

Orthologs for CPNE9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPNE9 36
  • 99.88 (n)
  • 100 (a)
CPNE9 37
  • 100 (a)
(Bos Taurus)
Mammalia CPNE9 36
  • 94.86 (n)
  • 98.8 (a)
CPNE9 37
  • 98 (a)
(Canis familiaris)
Mammalia CPNE9 36
  • 93.84 (n)
  • 98.91 (a)
CPNE9 37
  • 99 (a)
(Mus musculus)
Mammalia Cpne9 36
  • 91.68 (n)
  • 98.55 (a)
Cpne9 16
Cpne9 37
  • 99 (a)
(Monodelphis domestica)
Mammalia CPNE9 37
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
-- 37
  • 96 (a)
(Rattus norvegicus)
Mammalia Cpne9 36
  • 91.86 (n)
  • 98.73 (a)
(Gallus gallus)
Aves CPNE9 37
  • 85 (a)
(Anolis carolinensis)
Reptilia CPNE9 37
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne5 36
  • 75.22 (n)
  • 86.12 (a)
(Caenorhabditis elegans)
Secernentea cpna-4 37
  • 22 (a)
cpna-5 37
  • 23 (a)
gem-4 37
  • 39 (a)
nra-1 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
Species with no ortholog for CPNE9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPNE9 Gene

Gene Tree for CPNE9 (if available)
Gene Tree for CPNE9 (if available)

Paralogs for CPNE9 Gene

Paralogs for CPNE9 Gene

Selected SIMAP similar genes for CPNE9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPNE9: view

Variants for CPNE9 Gene

Sequence variations from dbSNP and Humsavar for CPNE9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs182380 -- 9,715,151(-) AGGCC(A/C)AACAT intron-variant
rs184118 -- 9,708,833(-) cacgg(C/T)gaaac intron-variant
rs184907 -- 9,708,877(-) gcggg(C/T)ggatc intron-variant
rs187310 -- 9,712,650(-) TTTAC(A/G)GGGAG intron-variant
rs213865 -- 9,705,081(+) CGCCT(C/T)CGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE9 Gene

Variant ID Type Subtype PubMed ID
esv2673134 CNV Deletion 23128226

Relevant External Links for CPNE9 Gene

HapMap Linkage Disequilibrium report

Disorders for CPNE9 Gene

Relevant External Links for CPNE9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CPNE9: view

No data available for UniProtKB/Swiss-Prot for CPNE9 Gene

Publications for CPNE9 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for CPNE9 Gene

Sources for CPNE9 Gene

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