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Aliases for CPNE9 Gene

Aliases for CPNE9 Gene

  • Copine Family Member 9 2 3
  • Copine Family Member IX 2 5
  • Copine IX 4

External Ids for CPNE9 Gene

Previous GeneCards Identifiers for CPNE9 Gene

  • GC03P009724
  • GC03P009681
  • GC03P009745

Summaries for CPNE9 Gene

GeneCards Summary for CPNE9 Gene

CPNE9 (Copine Family Member 9) is a Protein Coding gene. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE9 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE9 Gene

Genomics for CPNE9 Gene

Regulatory Elements for CPNE9 Gene

Enhancers for CPNE9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPNE9 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPNE9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE9 Gene

9,703,807 bp from pter
9,729,908 bp from pter
26,102 bases
Plus strand

Genomic View for CPNE9 Gene

Genes around CPNE9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE9 Gene

Proteins for CPNE9 Gene

  • Protein details for CPNE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L430
    • A6NDX6
    • A8MSP8

    Protein attributes for CPNE9 Gene

    553 amino acids
    Molecular mass:
    61864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE9 Gene


neXtProt entry for CPNE9 Gene

Proteomics data for CPNE9 Gene at MOPED

Post-translational modifications for CPNE9 Gene

  • Glycosylation at Asn 95
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE9 Gene

No data available for DME Specific Peptides for CPNE9 Gene

Domains & Families for CPNE9 Gene

Gene Families for CPNE9 Gene

Protein Domains for CPNE9 Gene


Suggested Antigen Peptide Sequences for CPNE9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE9: view

Function for CPNE9 Gene

Molecular function for CPNE9 Gene

UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
genes like me logo Genes that share phenotypes with CPNE9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE9 Gene

Localization for CPNE9 Gene

Subcellular locations from

Jensen Localization Image for CPNE9 Gene COMPARTMENTS Subcellular localization image for CPNE9 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPNE9 Gene

Pathways & Interactions for CPNE9 Gene

SuperPathways for CPNE9 Gene

No Data Available

Interacting Proteins for CPNE9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373343 for CPNE9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CPNE9 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPNE9 Gene

Drugs & Compounds for CPNE9 Gene

(1) Drugs for CPNE9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CPNE9: view

Transcripts for CPNE9 Gene

Unigene Clusters for CPNE9 Gene

Copine family member IX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3: -

Relevant External Links for CPNE9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE9 Gene

mRNA expression in normal human tissues for CPNE9 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE9 Gene

This gene is overexpressed in Brain - Cerebellum (x9.8), Brain - Cerebellar Hemisphere (x9.2), Brain - Cortex (x9.0), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Anterior cingulate cortex (BA24) (x4.5).

Protein differential expression in normal tissues from HIPED for CPNE9 Gene

This gene is overexpressed in Brain (51.5) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPNE9 Gene

SOURCE GeneReport for Unigene cluster for CPNE9 Gene Hs.121335

mRNA Expression by UniProt/SwissProt for CPNE9 Gene

Tissue specificity: Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with CPNE9: view

Protein tissue co-expression partners for CPNE9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPNE9 Gene

Orthologs for CPNE9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE9 35
  • 94.86 (n)
  • 98.8 (a)
CPNE9 36
  • 98 (a)
(Canis familiaris)
Mammalia CPNE9 35
  • 93.84 (n)
  • 98.91 (a)
CPNE9 36
  • 99 (a)
(Mus musculus)
Mammalia Cpne9 35
  • 91.68 (n)
  • 98.55 (a)
Cpne9 16
Cpne9 36
  • 99 (a)
(Pan troglodytes)
Mammalia CPNE9 35
  • 99.88 (n)
  • 100 (a)
CPNE9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpne9 35
  • 91.86 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia CPNE9 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves CPNE9 36
  • 85 (a)
(Anolis carolinensis)
Reptilia CPNE9 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne5 35
  • 75.22 (n)
  • 86.12 (a)
(Caenorhabditis elegans)
Secernentea cpna-4 36
  • 22 (a)
cpna-5 36
  • 23 (a)
gem-4 36
  • 39 (a)
nra-1 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for CPNE9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPNE9 Gene

Gene Tree for CPNE9 (if available)
Gene Tree for CPNE9 (if available)

Paralogs for CPNE9 Gene

Paralogs for CPNE9 Gene

(9) SIMAP similar genes for CPNE9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPNE9: view

Variants for CPNE9 Gene

Sequence variations from dbSNP and Humsavar for CPNE9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs708571 -- 9,716,070(+) AGCCC(A/G)GCAAT intron-variant
rs708575 -- 9,721,960(-) gcctg(G/T)gtgac intron-variant
rs708576 -- 9,711,444(+) gctcc(C/T)gacct intron-variant
rs182380 -- 9,715,151(-) AGGCC(A/C)AACAT intron-variant
rs375934 -- 9,711,359(+) CACCA(C/G/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE9 Gene

Variant ID Type Subtype PubMed ID
esv2673134 CNV Deletion 23128226

Variation tolerance for CPNE9 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPNE9 Gene

Disorders for CPNE9 Gene

Relevant External Links for CPNE9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPNE9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE9 Gene

Publications for CPNE9 Gene

  1. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo J.C. … Yoon T.J. (J. Dermatol. Sci. 2013) 3 4 67
  2. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3

Products for CPNE9 Gene

Sources for CPNE9 Gene