CPNE9 Gene
protein-coding GIFtS: 45
GCID: GC03P009745
|
|
copine family member IX
| |
Aliases
for CPNE9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Copine Family Member IX1 2 | | Copine IX2 3 | | KIAA42171 | | Copine-91 | | Copine-Like Protein2 |
Export aliases for CPNE9 gene to outside databasesPrevious GC identifers: GC03P009724 GC03P009681 |
Summaries
for CPNE9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CPNE9_HUMAN, Q8IYJ1Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity)
|
Genomic Views
for CPNE9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPNE9 gene promoter:
HOXA9 Pax-5 MyoD Meis-1b E47 HEN1 IRF-2 Sox9 Cart-1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPNE9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3CPNE9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P009745: view genomic region
(about GC identifiers)
Start:
|
9,745,491 bp from pter |
End:
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9,771,592 bp from pter |
Size:
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26,102 bases |
Orientation:
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plus strand |
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Proteins
for CPNE9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPNE9_HUMAN, Q8IYJ1 (See
protein sequence)Recommended Name: Copine-9 Size: 553 amino acids; 61864 Da
Secondary accessions: A1L430 A6NDX6 A8MSP8Alternative splicing: 2 isoforms: Q8IYJ1-1 Q8IYJ1-2 Explore the universe of human proteins at neXtProt for CPNE9: NX_Q8IYJ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYJ1
CPNE9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_705899.2
ENSEMBL proteins: ENSP00000373343 ENSP00000373342 ENSP00000273027
Human Recombinant Protein Products:
CPNE9 Antibody Products:
Assay Products for CPNE9: |
Protein
Domains /
Families
for CPNE9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPNE9 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYJ1ProtoNet protein and cluster: Q8IYJ1 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: CPNE9_HUMAN, Q8IYJ1Similarity: Belongs to the copine familySimilarity: Contains 2 C2 domainsSimilarity: Contains 1 VWFA domain |
Function
for CPNE9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CPNE9_HUMAN, Q8IYJ1Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CPNE9 (NM_153635) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE9 |
|
Pathways & Interactions
for CPNE9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE9
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CPNE9 (ENSP000003733434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CPNE9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPNE9
1 HMDB Compound for CPNE9 About this table
Search CenterWatch for drugs/clinical trials and news about CPNE9
|
Transcripts
for CPNE9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPNE9 gene: NM_153635.2 Unigene Cluster for CPNE9: Copine family member IX Hs.121335 [show with all ESTs]Unigene Representative Sequence: NM_1536354 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000383832(uc003bsd.3 uc021wst.1) ENST00000383831 ENST00000491802
ENST00000273027
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CPNE9 (NM_153635) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE9 |
Additional cDNA sequence: BC035735.1 BC130375.1 3 DOTS entries: DT.200024 DT.100017776 DT.120843447 24/25 AceView cDNA sequences (see all 25): BF447456 CF456720 BC035735 BQ086253 Z46094 NM_153635 Z40894 BG203480 BM545574 BU071439 BU101941 BG181185 BQ787424 CA307982 AL536178 BQ130289 BU789235 BU783425 BM313953 BI710891 BX431132 AV750734 AL566221 AA758411
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE9 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CPNE9
|
Expression
for CPNE9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPNE9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATAATAA
About this image
See CPNE9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPNE9
SOURCE GeneReport for Unigene cluster: Hs.121335
SABiosciences Custom PCR Arrays for CPNE9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPNE9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPNE9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPNE9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPNE9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE9 |
Orthologs
for CPNE9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPNE9 gene from 4/20 species (see all 20) About this table
ENSEMBL Gene Tree for CPNE9 (if available)
TreeFam Gene Tree for CPNE9 (if available) |
Paralogs
for CPNE9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPNE9 gene
- CPNE82 CPNE22 CPNE62 CPNE42 CPNE72 CPNE32 CPNE12 CPNE52
9 SIMAP similar genes for CPNE9 using alignment to 2 protein entries: CPNE9_HUMAN (see all proteins):CPNE8 CPNE5 DKFZp666C234 CPNE2 CPNE3 CPNE6
CPNE4 CPNE7 CPNE1
CPNE9 for paralogs About GeneDecksing
|
Genomic Variants
for CPNE9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPNE9 (9745491 - 9771592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CPNE9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPNE9 |
|
Disorders
/ Diseases
for CPNE9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPNE9 for disorders About GeneDecksing
2  diseases for CPNE9: About MalaCardshermaphroditism infertility
Human Genome Epidemiology (HuGE) Navigator: CPNE9 (3 documents)
Export disorders for CPNE9 gene to outside databases
|
Publications
for CPNE9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPNE9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CPNE9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (1998)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Bridging expressed sequence alignments through targeted cDNA sequencing. (PubMed id 15028280)1 Xie H....Gill-More R. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein. (PubMed id 11123945)1 Tomsig J.L. and Creutz C.E. (2000)
|
External Searches for CPNE9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CPNE9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPNE9 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CPNE9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CPNE9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CPNE9 gene:
Search GeneIP for patents involving CPNE9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CPNE9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPNE9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPNE9 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPNE9 | | OriGene 3'-UTR Clone for CPNE9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CPNE9 | | OriGene Custom Protein Services for CPNE9 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPNE9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPNE9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPNE9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPNE9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPNE9 |
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| | | | Search Tocris compounds for CPNE9 |
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 | | | CPNE9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE9 |
|  |  |  | | | | ThermoFisher Antibodies for CPNE9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE9 |
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