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Aliases for CPNE8 Gene

Aliases for CPNE8 Gene

  • Copine VIII 2 3 4

External Ids for CPNE8 Gene

Previous GeneCards Identifiers for CPNE8 Gene

  • GC12M037332
  • GC12M039045
  • GC12M036072

Summaries for CPNE8 Gene

Entrez Gene Summary for CPNE8 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE8 Gene

CPNE8 (Copine VIII) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE8 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Wiki entry for CPNE8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE8 Gene

Genomics for CPNE8 Gene

Regulatory Elements for CPNE8 Gene

Genomic Location for CPNE8 Gene

Chromosome:
12
Start:
38,646,822 bp from pter
End:
38,907,430 bp from pter
Size:
260,609 bases
Orientation:
Minus strand

Genomic View for CPNE8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE8 Gene

Proteins for CPNE8 Gene

  • Protein details for CPNE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YQ8-CPNE8_HUMAN
    Recommended name:
    Copine-8
    Protein Accession:
    Q86YQ8
    Secondary Accessions:
    • Q2TB41
    • Q86VY2

    Protein attributes for CPNE8 Gene

    Size:
    564 amino acids
    Molecular mass:
    63108 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE8 Gene

Proteomics data for CPNE8 Gene at MOPED

Post-translational modifications for CPNE8 Gene

  • Ubiquitination at Lys 405
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE8 Gene

Antibody Products

No data available for DME Specific Peptides for CPNE8 Gene

Domains & Families for CPNE8 Gene

Gene Families for CPNE8 Gene

Protein Domains for CPNE8 Gene

Suggested Antigen Peptide Sequences for CPNE8 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YQ8

UniProtKB/Swiss-Prot:

CPNE8_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the copine family.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE8: view

Function for CPNE8 Gene

Molecular function for CPNE8 Gene

UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Ontology (GO) - Molecular Function for CPNE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CPNE8: view

Phenotypes for CPNE8 Gene

GenomeRNAi human phenotypes for CPNE8:
genes like me logo Genes that share phenotypes with CPNE8: view

Animal Model Products

miRNA for CPNE8 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE8 Gene

Localization for CPNE8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE8 Gene COMPARTMENTS Subcellular localization image for CPNE8 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CPNE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CPNE8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE8 Gene

Pathways & Interactions for CPNE8 Gene

SuperPathways for CPNE8 Gene

No Data Available

Interacting Proteins for CPNE8 Gene

Gene Ontology (GO) - Biological Process for CPNE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CPNE8: view

No data available for Pathways by source and SIGNOR curated interactions for CPNE8 Gene

Drugs & Compounds for CPNE8 Gene

(1) Drugs for CPNE8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CPNE8: view

Transcripts for CPNE8 Gene

Unigene Clusters for CPNE8 Gene

Copine VIII:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE8 Gene

No ASD Table

Relevant External Links for CPNE8 Gene

GeneLoc Exon Structure for
CPNE8
ECgene alternative splicing isoforms for
CPNE8

Expression for CPNE8 Gene

mRNA expression in normal human tissues for CPNE8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE8 Gene

This gene is overexpressed in Brain (40.2) and Urine (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE8 Gene



SOURCE GeneReport for Unigene cluster for CPNE8 Gene Hs.40910

genes like me logo Genes that share expression patterns with CPNE8: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CPNE8 Gene

Orthologs for CPNE8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPNE8 35
  • 93.56 (n)
  • 97.7 (a)
CPNE8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE8 35
  • 94.27 (n)
  • 99.65 (a)
CPNE8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne8 35
  • 89.07 (n)
  • 98.76 (a)
Cpne8 16
Cpne8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPNE8 35
  • 99.59 (n)
  • 99.82 (a)
CPNE8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne8 35
  • 88.53 (n)
  • 98.94 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE8 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPNE8 35
  • 83.15 (n)
  • 92.32 (a)
CPNE8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPNE8 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne8 35
  • 79.96 (n)
  • 89.72 (a)
zebrafish
(Danio rerio)
Actinopterygii cpne8 35
  • 72.18 (n)
  • 81.12 (a)
cpne8 36
  • 79 (a)
OneToMany
CPNE8 (2 of 2) 36
  • 90 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpna-1 36
  • 13 (a)
ManyToMany
cpna-2 36
  • 2 (a)
ManyToMany
cpna-3 36
  • 29 (a)
ManyToMany
cpna-4 36
  • 23 (a)
ManyToMany
cpna-5 36
  • 24 (a)
ManyToMany
gem-4 36
  • 41 (a)
ManyToMany
nra-1 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10267 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CPNE8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE8 Gene

ENSEMBL:
Gene Tree for CPNE8 (if available)
TreeFam:
Gene Tree for CPNE8 (if available)

Paralogs for CPNE8 Gene

Paralogs for CPNE8 Gene

(8) SIMAP similar genes for CPNE8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPNE8: view

Variants for CPNE8 Gene

Sequence variations from dbSNP and Humsavar for CPNE8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs826836 -- 38,791,604(-) ACACA(C/T)TTCAG intron-variant
rs826837 -- 38,790,723(-) gtggt(A/G)tatat intron-variant
rs826838 -- 38,712,929(+) CAATA(C/T)GATGA intron-variant
rs826839 -- 38,713,467(+) TGTTT(A/T)ATCTG intron-variant
rs826840 -- 38,714,241(+) TGCTA(C/T)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE8 Gene

Variant ID Type Subtype PubMed ID
nsv898987 CNV Gain 21882294
esv2422488 CNV Duplication 17116639
nsv469356 CNV Gain 19166990
esv2675202 CNV Deletion 23128226
nsv675 CNV Insertion 18451855
nsv676 CNV Loss 18451855
esv2656716 CNV Deletion 23128226
nsv899009 CNV Loss 21882294
nsv52810 CNV Loss 16902084

Variation tolerance for CPNE8 Gene

Residual Variation Intolerance Score: 8.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE8 Gene

HapMap Linkage Disequilibrium report
CPNE8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE8 Gene

Disorders for CPNE8 Gene

Relevant External Links for CPNE8

Genetic Association Database (GAD)
CPNE8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE8
genes like me logo Genes that share disorders with CPNE8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE8 Gene

Publications for CPNE8 Gene

  1. Cloning, molecular characterization, and expression analysis of copine 8. (PMID: 12670487) Maitra R. … Lee B. (Biochem. Biophys. Res. Commun. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 67

Products for CPNE8 Gene

Sources for CPNE8 Gene

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