Aliases for CPNE8 Gene
External Ids for CPNE8 Gene
- HGNC: 23498
- Entrez Gene: 144402
- Ensembl: ENSG00000139117
- UniProtKB: Q86YQ8
Previous GeneCards Identifiers for CPNE8 Gene
- GC12M037332
- GC12M039045
- GC12M036072
Summaries for CPNE8 Gene
-
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPNE8 Gene
CPNE8 (Copine 8) is a Protein Coding gene. An important paralog of this gene is CPNE5.
UniProtKB/Swiss-Prot for CPNE8 Gene
-
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE8 Gene
Genomics for CPNE8 Gene
Regulatory Elements for CPNE8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G038384 | 1.1 | Ensembl ENCODE | 7.6 | +521.5 | 521458 | 2.5 | CTCF TFAP4 FOXA2 TAF1 JUN MAX BRCA1 RAD21 RFX5 SMC3 | CPNE8 ENSG00000257718 GC12P038428 GC12M038330 |
| GH12G038710 | 0.5 | FANTOM5 | 11.1 | +197.1 | 197092 | 0.2 | ZNF335 ZNF263 | CPNE8 ENSG00000258119 ENSG00000257718 |
| GH12G038315 | 1.1 | ENCODE | 4.5 | +590.6 | 590647 | 1.7 | PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 CBX5 | CPNE8 ALG10B GC12P038329 |
| GH12G038138 | 1 | Ensembl ENCODE | 4 | +768.6 | 768611 | 1.0 | CTCF ZNF223 SIN3A ZNF2 RAD21 RFX5 ZNF324 ZFHX2 ZNF366 SCRT2 | CPNE8 ENSG00000274293 AK6P2 |
| GH12G038123 | 0.8 | ENCODE | 4 | +783.2 | 783167 | 1.4 | ELF3 SOX13 DRAP1 FOXA2 SAP130 ZNF384 ZNF644 RARA YY1 RERE | ENSG00000257718 CPNE8 ENSG00000274293 AK6P2 |
Regulatory Element Products
Genomic Location for CPNE8 Gene
- Chromosome:
- 12
- Start:
- 38,646,822 bp from pter
- End:
- 38,907,430 bp from pter
- Size:
- 260,609 bases
- Orientation:
- Minus strand
Genomic View for CPNE8 Gene
- Cytogenetic band:
-
- 12q12 by Ensembl
- 12q12 by Entrez Gene
- 12q12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CPNE8 Gene
Proteins for CPNE8 Gene
-
Protein details for CPNE8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YQ8-CPNE8_HUMAN
- Recommended name:
- Copine-8
- Protein Accession:
- Q86YQ8
- Q2TB41
- Q86VY2
Protein attributes for CPNE8 Gene
- Size:
- 564 amino acids
- Molecular mass:
- 63108 Da
- Quaternary structure:
- No Data Available
Protein Expression for CPNE8 Gene
Post-translational modifications for CPNE8 Gene
Other Protein References for CPNE8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CPNE8
- Invitrogen Antibodies for CPNE8
- antibodies-online Antibodies for CPNE8: See all 33
- Search GeneTex for Antibodies for CPNE8
Protein Products
-
OriGene Purified Proteins for CPNE8
- Search Origene for MassSpec and Protein Over-expression Lysates for CPNE8
- Origene Custom Protein Services for CPNE8
- antibodies-online Proteins for CPNE8: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CPNE8
Assay Products
No data available for DME Specific Peptides for CPNE8 Gene
Domains & Families for CPNE8 Gene
Gene Families for CPNE8 Gene
- HGNC:
Protein Domains for CPNE8 Gene
Suggested Antigen Peptide Sequences for CPNE8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86YQ8- Family:
-
- Belongs to the copine family.
Function for CPNE8 Gene
Molecular function for CPNE8 Gene
- UniProtKB/Swiss-Prot Function:
- Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for CPNE8 Gene
- GenomeRNAi human phenotypes for CPNE8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CPNE8
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CPNE8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CPNE8 gene
- Search ViGene Biosciences for CPNE8
CRISPR Products
-
OriGene CRISPR knockouts for CPNE8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPNE8
- GenScript: Design CRISPR guide RNA sequences for CPNE8
miRNA for CPNE8 Gene
- miRTarBase miRNAs that target CPNE8
miRNA Products
- Search ViGene Biosciences for CPNE8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CPNE8
- Browse OriGene Inhibitory RNA Products For CPNE8
-
ViGene Biosciences ready-to-package AAV shRNAs for CPNE8 gene
Clone Products
-
OriGene ORF clones in human for CPNE8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CPNE8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CPNE8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CPNE8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CPNE8
-
ViGene Biosciences adenoviral particle packaged cDNA for CPNE8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CPNE8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CPNE8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE8 Gene
Localization for CPNE8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 20458337 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE8 Gene
Pathways & Interactions for CPNE8 Gene
Interacting Proteins for CPNE8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for CPNE8 Gene
Drugs & Compounds for CPNE8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for CPNE8 Gene
mRNA/cDNA for CPNE8 Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (63) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CPNE8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPNE8
- GenScript: Design CRISPR guide RNA sequences for CPNE8
miRNA Products
- Search ViGene Biosciences for CPNE8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CPNE8
- Browse OriGene Inhibitory RNA Products For CPNE8
-
ViGene Biosciences ready-to-package AAV shRNAs for CPNE8 gene
Clone Products
-
OriGene ORF clones in human for CPNE8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CPNE8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CPNE8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CPNE8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CPNE8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPNE8 Gene
NURSA nuclear receptor signaling pathways regulating expression of CPNE8 Gene:
CPNE8SOURCE GeneReport for Unigene cluster for CPNE8 Gene:
Hs.40910Evidence on tissue expression from TISSUES for CPNE8 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for CPNE8
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE8 Gene
Orthologs for CPNE8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CPNE8 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CPNE8 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CPNE8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CPNE8 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cpne8 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cpne8 34 |
|
||
| chicken (Gallus gallus) |
Aves | CPNE8 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CPNE8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cpne8 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CPNE8 (2 of 2) 35 |
|
OneToMany | |
| cpne8 34 35 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | gem-4 35 |
|
ManyToMany | |
| nra-1 35 |
|
ManyToMany | |||
| cpna-3 35 |
|
ManyToMany | |||
| cpna-5 35 |
|
ManyToMany | |||
| cpna-4 35 |
|
ManyToMany | |||
| cpna-1 35 |
|
ManyToMany | |||
| cpna-2 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10267 34 |
|
- Species where no ortholog for CPNE8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CPNE8 Gene
Variants for CPNE8 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011004 | -- | 38,853,922(+) | CCCAG(C/T)ACAAC | intron-variant | |
| rs1000031331 | -- | 38,808,191(+) | TCAGC(A/G)TGGCT | intron-variant | |
| rs1000031880 | -- | 38,902,050(+) | TTCAA(A/G)CTTCA | intron-variant | |
| rs1000034419 | -- | 38,664,631(+) | TTGAG(A/G)TAAAC | intron-variant | |
| rs1000039302 | -- | 38,713,292(+) | CTTCT(C/T)TCATA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1468n100 | CNV | gain | 25217958 |
| dgv1488n100 | CNV | gain | 25217958 |
| esv2422488 | CNV | duplication | 17116639 |
| esv2656716 | CNV | deletion | 23128226 |
| esv2675202 | CNV | deletion | 23128226 |
| esv2761088 | CNV | gain | 21179565 |
| esv3629242 | CNV | loss | 21293372 |
| esv3629244 | CNV | loss | 21293372 |
| esv3629245 | CNV | loss | 21293372 |
| nsv1045040 | CNV | gain | 25217958 |
| nsv1047623 | CNV | loss | 25217958 |
| nsv469356 | CNV | gain | 19166990 |
| nsv479559 | CNV | novel sequence insertion | 20440878 |
| nsv52810 | CNV | deletion | 16902084 |
| nsv558350 | CNV | gain | 21841781 |
| nsv558574 | CNV | gain | 21841781 |
| nsv675 | CNV | insertion | 18451855 |
| nsv676 | CNV | deletion | 18451855 |
Relevant External Links for CPNE8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CPNE8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE8 Gene
Disorders for CPNE8 Gene
Relevant External Links for CPNE8
No disorders were found for CPNE8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE8 Gene
Publications for CPNE8 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Cloning, molecular characterization, and expression analysis of copine 8. (PMID: 12670487) Maitra R. … Lee B. (Biochem. Biophys. Res. Commun. 2003) 2 3 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for CPNE8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for CPNE8
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- OriGene qPCR primer pairs for CPNE8
- OriGene CRISPR knockouts for CPNE8
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for CPNE8 in any vector
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for CPNE8
- Novus Biologicals proteins and lysates for CPNE8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CPNE8: See all 33
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- antibodies-online Proteins for CPNE8: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CPNE8
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- ViGene Biosciences adenoviral particle packaged cDNA for CPNE8 gene
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- Search ViGene Biosciences for CPNE8
- Horizon Cell Lines for CPNE8
- Cyagen custom Knockout/knockin (KOKI) mouse models for CPNE8
- VectorBuilder custom plasmid, inducible vectors for CPNE8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CPNE8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CPNE8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




