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Aliases for CPNE8 Gene

Aliases for CPNE8 Gene

  • Copine 8 2 3
  • Copine VIII 2 4 5

External Ids for CPNE8 Gene

Previous GeneCards Identifiers for CPNE8 Gene

  • GC12M037332
  • GC12M039045
  • GC12M036072

Summaries for CPNE8 Gene

Entrez Gene Summary for CPNE8 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE8 Gene

CPNE8 (Copine 8) is a Protein Coding gene. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE8 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Wiki entry for CPNE8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE8 Gene

Genomics for CPNE8 Gene

Regulatory Elements for CPNE8 Gene

Enhancers for CPNE8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPNE8 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPNE8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE8 Gene

38,646,822 bp from pter
38,907,430 bp from pter
260,609 bases
Minus strand

Genomic View for CPNE8 Gene

Genes around CPNE8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE8 Gene

Proteins for CPNE8 Gene

  • Protein details for CPNE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2TB41
    • Q86VY2

    Protein attributes for CPNE8 Gene

    564 amino acids
    Molecular mass:
    63108 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE8 Gene


neXtProt entry for CPNE8 Gene

Proteomics data for CPNE8 Gene at MOPED

Post-translational modifications for CPNE8 Gene

  • Ubiquitination at Lys 405
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE8 Gene

No data available for DME Specific Peptides for CPNE8 Gene

Domains & Families for CPNE8 Gene

Gene Families for CPNE8 Gene

Protein Domains for CPNE8 Gene

Suggested Antigen Peptide Sequences for CPNE8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE8: view

Function for CPNE8 Gene

Molecular function for CPNE8 Gene

UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Ontology (GO) - Molecular Function for CPNE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CPNE8: view
genes like me logo Genes that share phenotypes with CPNE8: view

Animal Model Products

miRNA for CPNE8 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE8 Gene

Localization for CPNE8 Gene

Subcellular locations from

Jensen Localization Image for CPNE8 Gene COMPARTMENTS Subcellular localization image for CPNE8 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CPNE8 Gene

Pathways & Interactions for CPNE8 Gene

SuperPathways for CPNE8 Gene

No Data Available

Interacting Proteins for CPNE8 Gene

Gene Ontology (GO) - Biological Process for CPNE8 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPNE8 Gene

Drugs & Compounds for CPNE8 Gene

(1) Drugs for CPNE8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CPNE8: view

Transcripts for CPNE8 Gene

Unigene Clusters for CPNE8 Gene

Copine VIII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE8 Gene

No ASD Table

Relevant External Links for CPNE8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE8 Gene

mRNA expression in normal human tissues for CPNE8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE8 Gene

This gene is overexpressed in Brain (40.2) and Urine (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE8 Gene

SOURCE GeneReport for Unigene cluster for CPNE8 Gene Hs.40910

genes like me logo Genes that share expression patterns with CPNE8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CPNE8 Gene

Orthologs for CPNE8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE8 35
  • 93.56 (n)
  • 97.7 (a)
CPNE8 36
  • 98 (a)
(Canis familiaris)
Mammalia CPNE8 35
  • 94.27 (n)
  • 99.65 (a)
CPNE8 36
  • 97 (a)
(Mus musculus)
Mammalia Cpne8 35
  • 89.07 (n)
  • 98.76 (a)
Cpne8 16
Cpne8 36
  • 97 (a)
(Pan troglodytes)
Mammalia CPNE8 35
  • 99.59 (n)
  • 99.82 (a)
CPNE8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpne8 35
  • 88.53 (n)
  • 98.94 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE8 36
  • 95 (a)
(Gallus gallus)
Aves CPNE8 35
  • 83.15 (n)
  • 92.32 (a)
CPNE8 36
  • 89 (a)
(Anolis carolinensis)
Reptilia CPNE8 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne8 35
  • 79.96 (n)
  • 89.72 (a)
(Danio rerio)
Actinopterygii cpne8 35
  • 72.18 (n)
  • 81.12 (a)
cpne8 36
  • 79 (a)
CPNE8 (2 of 2) 36
  • 90 (a)
(Caenorhabditis elegans)
Secernentea cpna-1 36
  • 13 (a)
cpna-2 36
  • 2 (a)
cpna-3 36
  • 29 (a)
cpna-4 36
  • 23 (a)
cpna-5 36
  • 24 (a)
gem-4 36
  • 41 (a)
nra-1 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10267 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for CPNE8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE8 Gene

Gene Tree for CPNE8 (if available)
Gene Tree for CPNE8 (if available)

Paralogs for CPNE8 Gene

Paralogs for CPNE8 Gene

(8) SIMAP similar genes for CPNE8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPNE8: view

Variants for CPNE8 Gene

Sequence variations from dbSNP and Humsavar for CPNE8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1968901 -- 38,766,635(-) AGTAT(A/C)AAATG intron-variant
rs1996879 -- 38,811,798(+) GCCCA(C/T)GAGTT intron-variant
rs1996880 -- 38,774,160(-) AATAT(C/T)TTCCA intron-variant
rs2029168 -- 38,693,376(+) gtttg(A/T)tatct intron-variant
rs2056159 -- 38,876,615(-) TTTTT(C/G)TTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE8 Gene

Variant ID Type Subtype PubMed ID
nsv898987 CNV Gain 21882294
esv2422488 CNV Duplication 17116639
nsv469356 CNV Gain 19166990
esv2675202 CNV Deletion 23128226
nsv675 CNV Insertion 18451855
nsv676 CNV Loss 18451855
esv2656716 CNV Deletion 23128226
nsv899009 CNV Loss 21882294
nsv52810 CNV Loss 16902084

Variation tolerance for CPNE8 Gene

Residual Variation Intolerance Score: 8.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPNE8 Gene

Disorders for CPNE8 Gene

Relevant External Links for CPNE8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPNE8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE8 Gene

Publications for CPNE8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Cloning, molecular characterization, and expression analysis of copine 8. (PMID: 12670487) Maitra R. … Lee B. (Biochem. Biophys. Res. Commun. 2003) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CPNE8 Gene

Sources for CPNE8 Gene