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CPNE8 Gene

protein-coding   GIFtS: 51
GCID: GC12M039045

Copine VIII

  Search for CPNE8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine VIII1 2 3
copine-82

External Ids:    HGNC: 234981   Entrez Gene: 1444022   Ensembl: ENSG000001391177   UniProtKB: Q86YQ83   

Export aliases for CPNE8 gene to outside databases

Previous GC identifers: GC12M037332 GC12M036072


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE8 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two
N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. (provided by RefSeq, Jul
2008)

GeneCards Summary for CPNE8 Gene:
CPNE8 (copine VIII) is a protein-coding gene. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE8_HUMAN, Q86YQ8
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)

Gene Wiki entry for CPNE8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE8 gene promoter:
         ER-alpha   Bach1   GATA-3   Bach2   ATF-2   FOXO3   E4BP4   FOXO3b   HOXA5   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE8 promoter sequence
   Search Chromatin IP Primers for CPNE8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

CPNE8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M039045:  view genomic region     (about GC identifiers)

Start:
39,040,624 bp from pter      End:
39,301,232 bp from pter
Size:
260,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPNE8_HUMAN, Q86YQ8 (See protein sequence)
Recommended Name: Copine-8  
Size: 564 amino acids; 63108 Da
Secondary accessions: Q2TB41

Explore the universe of human proteins at neXtProt for CPNE8: NX_Q86YQ8

Explore proteomics data for CPNE8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys405
  • Modification sites at PhosphoSitePlus

  • See CPNE8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_705898.1  
    ENSEMBL proteins: 
     ENSP00000329748   ENSP00000439237   ENSP00000353633   ENSP00000447761  

    CPNE8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPNE8

     
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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    CPNE8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPNE8
    Cloud-Clone Corp. CLIAs for CPNE8
    Search eBioscience for ELISAs for CPNE8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q86YQ8

    ProtoNet protein and cluster: Q86YQ8

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB002035 Von Willebrand factor type A domain signature
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE8_HUMAN, Q86YQ8
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with CPNE8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE8_HUMAN, Q86YQ8
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CPNE8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPNE8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPNE8:
    hsa-mir-16-5p (MIRT051072), hsa-mir-124-3p (MIRT022217), hsa-mir-30a-5p (MIRT005134)

    Block miRNA regulation of human, mouse, rat CPNE8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE8 (see all 61):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-4305 hsa-miR-25 hsa-miR-3653 hsa-miR-30d hsa-miR-218 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCPNE8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPNE8
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE8

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CPNE8

    Clone
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    OriGene clones in human, mouse for CPNE8 (see all 9)
    OriGene ORF clones in mouse, rat for CPNE8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE8 (NM_153634)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE8

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with CPNE8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE8
    Interactions:

        Search GeneGlobe Interaction Network for CPNE8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for CPNE8 (Q86YQ83 ENSP000003297484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP2Q064813I2D: score=1 
    ARRB1P494073I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE8

    1 HMDB Compound for CPNE8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPNE8 gene: 
    NM_153634.2  

    Unigene Cluster for CPNE8:

    Copine VIII
    Hs.40910  [show with all ESTs]
    Unigene Representative Sequence: BX538055
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552259 ENST00000331366(uc001rls.1) ENST00000538596(uc001rlr.1)
    ENST00000546603 ENST00000360449 ENST00000547417 ENST00000549842 ENST00000551855
    ENST00000550863
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE8 (see all 61):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-4305 hsa-miR-25 hsa-miR-3653 hsa-miR-30d hsa-miR-218 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCPNE8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPNE8
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE8
    Clone
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    OriGene clones in human, mouse for CPNE8 (see all 9)
    OriGene ORF clones in mouse, rat for CPNE8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE8 (NM_153634)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE8
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE8
      QuantiFast Probe-based Assays in human, mouse, rat CPNE8

    Additional mRNA sequence: 

    AK074223.1 AK094998.1 AK098593.1 AK307908.1 AY177785.1 BC046366.1 BC048260.1 BC068040.1 
    BC110577.1 BC110578.1 BX538055.1 

    10 DOTS entries:

    DT.100690399  DT.442159  DT.100033997  DT.40188510  DT.92416947  DT.75146061  DT.91661483  DT.95110919 
    DT.97808340  DT.91718466 

    Selected AceView cDNA sequences (see all 63):

    AA976153 BC046366 BX111100 BC048260 AI014430 AI188010 AW014148 AW470493 
    BG034542 CA419647 BE646019 BM720158 CR610762 NM_153634 AK098593 BX091603 
    BC068040 BM672075 AA345575 BG152408 BX538055 BM922878 AW628630 AA995677 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPNE8 Expression
    About this image


    CPNE8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    CPNE8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40910
        Custom PCR Arrays for CPNE8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPNE8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne81 , 5 copine VIII1, 5 89.07(n)1
    98.76(a)1
      15 (45.21 cM)5
    668711  NM_025815.21  NP_080091.11 
     904874825 
    chicken
    (Gallus gallus)
    Aves CPNE81 copine VIII 83.15(n)
    92.32(a)
      417690  NM_001199460.1  NP_001186389.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE86
    copine VIII
    89(a)
    1 ↔ 1
    5(99025209-99105097)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cpne81 copine VIII 79.96(n)
    89.72(a)
      100124845  XM_002932194.2  XP_002932240.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cpne81 copine VIII 72.18(n)
    81.12(a)
      100332028  XM_002666955.2  XP_002667001.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gem-46
    nra-16
    (see all 7)
    Protein GEM-4 (gem-4) mRNA, complete cds
    Protein NRA-1, isoform a (nra-1) mRNA, complete cd...
    (see all 7)
    41(a)
    39(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    IV(11745640-11748685) WBGene00001577
    IV(17281455-17284199) WBGene00012128


    ENSEMBL Gene Tree for CPNE8 (if available)
    TreeFam Gene Tree for CPNE8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE8 gene
    CPNE92  CPNE22  CPNE62  CPNE32  CPNE52  CPNE42  CPNE72  CPNE12  
    8 SIMAP similar genes for CPNE8 using alignment to 4 protein entries:     CPNE8_HUMAN (see all proteins):
    CPNE9    CPNE5    CPNE4    CPNE2    CPNE1    CPNE3
    CPNE6    CPNE7

    Find genes that share paralogs with CPNE8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE8 (see all 5292)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674316081,2
    C--36321802(+) AAAGAAA/-GAAAG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1397499371,2
    --39045608(+) CTTTAC/TGAAGC 1 -- ds50010--------
    rs752314191,2
    C,F--39045702(+) GAGCTC/GTTCTC 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs125805031,2
    C,F,H--39045720(+) ATAGTC/GTTGGA 1 -- ds50015Minor allele frequency- G:0.00NS EA NA 422
    rs171255661,2
    C,F--39045801(+) CTAATC/GTTACA 1 -- ds50014Minor allele frequency- G:0.04NA WA 260
    rs171255701,2
    C,F,H--39045924(+) CAATCT/CATTAT 1 -- ds50018Minor allele frequency- C:0.01NA NS CSA 554
    rs1444424301,2
    --39045969(+) GGACAC/GTTCAA 1 -- ds50010--------
    rs111689851,2
    C,F,H--39045983(+) AATAAC/ATGATG 1 -- ds500125Minor allele frequency- A:0.18NA NS EA 2552
    rs79702731,2
    C,F,A,H--39046064(+) AAATCC/TGTAGG 1 -- ut31 ese39Minor allele frequency- T:0.45NA EA 392
    rs1930809931,2
    --39046065(+) AATCTA/GTAGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CPNE8 (39040624 - 39290624 bp, first 250kb of CPNE8)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CPNE8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656716CNV Deletion23128226
    esv2675202CNV Deletion23128226
    esv2422488CNV Duplication17116639
    nsv675CNV Insertion18451855
    nsv899009CNV Loss21882294
    nsv676CNV Loss18451855
    nsv52810CNV Loss16902084
    nsv898987CNV Gain21882294
    nsv469356CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE8
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for CPNE8:
    Distal arthrogryposis

    Find genes that share disorders with CPNE8           About GenesLikeMe

    Genetic Association Database (GAD): CPNE8

    Export disorders for CPNE8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE8 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CPNE8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning, molecular characterization, and expression analysis of copine 8. (PubMed id 12670487)1, 3 Maitra R.... Lee B. (Biochem. Biophys. Res. Commun. 2003)
    3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    4. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144402 HGNC: 23498 AceView: CPNE8 Ensembl:ENSG00000139117 euGenes: HUgn144402
    ECgene: CPNE8 H-InvDB: CPNE8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPNE8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE8 gene:
    Search GeneIP for patents involving CPNE8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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