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CPNE7 Gene

protein-coding   GIFtS: 53
GCID: GC16P089671

Copine VII

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine VII1 2 3
Copine 72
copine-72

External Ids:    HGNC: 23201   Entrez Gene: 271322   Ensembl: ENSG000001787737   OMIM: 6056895   UniProtKB: Q9UBL63   

Export aliases for CPNE7 gene to outside databases

Previous GC identifers: GC16P080962 GC16P090630 GC16P089345 GC16P089385 GC16P088169 GC16P089643 GC16P075338 GC16P089646 GC16P089652 GC16P089663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE7 Gene:
This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins.
The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein
may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for CPNE7 Gene:
CPNE7 (copine VII) is a protein-coding gene. Diseases associated with CPNE7 include sporadic breast cancer, and infertility. GO annotations related to this gene include transporter activity. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE7_HUMAN, Q9UBL6
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE7 gene promoter:
         RFX1   Pax-5   AML1a   LCR-F1   RORalpha2   E47   PPAR-alpha   POU2F1   POU2F1a   ZID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CPNE7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CPNE7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089671:  view genomic region     (about GC identifiers)

Start:
89,642,176 bp from pter      End:
89,663,654 bp from pter
Size:
21,479 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CPNE7_HUMAN, Q9UBL6 (See protein sequence)
Recommended Name: Copine-7  
Size: 633 amino acids; 70294 Da
Alternative splicing: 2 isoforms:  Q9UBL6-1   Q9UBL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPNE7: NX_Q9UBL6

Explore proteomics data for CPNE7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPNE7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055242.1  NP_705900.1  

    ENSEMBL proteins: 
     ENSP00000268720   ENSP00000431863   ENSP00000317374   ENSP00000435876   ENSP00000455086  
     ENSP00000434886  

    CPNE7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CPNE7
    OriGene Protein Over-expression Lysate for CPNE7
    OriGene MassSpec for CPNE7
    OriGene Custom Protein Services for CPNE7
    GenScript Custom Purified and Recombinant Proteins Services for CPNE7
    Novus Biologicals CPNE7 Protein
    Novus Biologicals CPNE7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPNE7

    CPNE7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CPNE7
    Novus Biologicals CPNE7 Antibodies
    Abcam antibodies for CPNE7
    Cloud-Clone Corp. Antibodies for CPNE7
    Search ThermoFisher Antibodies for CPNE7
    LSBio Antibodies in human, mouse, rat for CPNE7

    CPNE7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CPNE7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPNE7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPNE7
    Cloud-Clone Corp. CLIAs for CPNE7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UBL6

    ProtoNet protein and cluster: Q9UBL6

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE7_HUMAN, Q9UBL6
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE7_HUMAN, Q9UBL6
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Genatlas biochemistry entry for CPNE7:
    copine VII,member of the COPINE family,potential tumor suppressor,but excluded as a candidate gene in breast
    cancers (TSG16A,TSG16D)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10534407
    GO:0005515protein binding ----
         
    CPNE7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPNE7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPNE7:
    hsa-mir-214-3p (MIRT024962)

    Block miRNA regulation of human, mouse, rat CPNE7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CPNE7:
    hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmidCPNE7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPNE7
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPNE7

    Clone
    Products:
         
    OriGene clones in human, mouse for CPNE7 (see all 10)
    OriGene ORF clones in mouse, rat for CPNE7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPNE7 (NM_014427)
    Sino Biological Human cDNA Clone for CPNE7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CPNE7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CPNE7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE7
    Interactions:

        Search GeneGlobe Interaction Network for CPNE7

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CPNE7 (Q9UBL62, 3 ENSP000002687204) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253187 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253187 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253187 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253187 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253187 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS10534407
    GO:0006810transport TAS10534407

    CPNE7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE7

    1 HMDB Compound for CPNE7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPNE7 gene (2 alternative transcripts): 
    NM_014427.4  NM_153636.2  

    Unigene Cluster for CPNE7:

    Copine VII
    Hs.461775  [show with all ESTs]
    Unigene Representative Sequence: NM_014427
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268720(uc002fnp.3 uc002fnq.3) ENST00000525982 ENST00000319518
    ENST00000532500 ENST00000529800 ENST00000568977 ENST00000566398 ENST00000526232
    ENST00000564421
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CPNE7:
    hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmidCPNE7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPNE7
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE7
    Clone
    Products:
         
    OriGene clones in human, mouse for CPNE7 (see all 10)
    OriGene ORF clones in mouse, rat for CPNE7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPNE7 (NM_014427)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE7
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE7
      QuantiFast Probe-based Assays in human, mouse, rat CPNE7

    Additional mRNA sequence: 

    AJ133798.1 AK123526.1 BC035334.1 BC064577.1 

    12 DOTS entries:

    DT.436487  DT.100020557  DT.97805165  DT.92419539  DT.99977642  DT.91677324  DT.97824111  DT.97842295 
    DT.97842296  DT.40207136  DT.412253  DT.75149716 

    Selected AceView cDNA sequences (see all 60):

    BQ014714 BM987502 BM797064 AL539371 Z39757 AJ133798 NM_153636 BM824628 
    NM_014427 BM823274 BC064577 BQ009550 BC035334 AA704052 BV176556 BE797059 
    BI914091 BX444965 BI821589 BM793333 BI918287 BM544634 BX431644 BX420737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE7 expression in normal human tissues (normalized intensities)      CPNE7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTCTGCGG
    CPNE7 Expression
    About this image


    CPNE7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Stomach (Gastrointestinal Tract)
    CPNE7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461775
        Custom PCR Arrays for CPNE7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPNE7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne71 , 5 copine VII1, 5 84.51(n)1
    88.91(a)1
      8 (72.06 cM)5
    1022781  NM_170684.21  NP_733785.11 
     1231173745 
    chicken
    (Gallus gallus)
    Aves CPNE71 copine VII 83.15(n)
    82.46(a)
      415851  XM_414211.4  XP_414211.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    87(a)
    78(a)
    1 ↔ many
    1 ↔ many
    AAWZ02041805(1996-4997)
    GL343487.1(477082-517851)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cpne71 copine VII 72.71(n)
    79.35(a)
      100489407  XM_002933678.2  XP_002933724.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5645561 copine-7-like 72.69(n)
    74.56(a)
      564556  XM_687889.5  XP_692981.4 
    worm
    (Caenorhabditis elegans)
    Secernentea Y73F8A.193   -- 28(a)   IV(15361756-15368155)   --


    ENSEMBL Gene Tree for CPNE7 (if available)
    TreeFam Gene Tree for CPNE7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE7 gene
    CPNE92  CPNE22  CPNE62  CPNE32  CPNE52  CPNE82  CPNE42  CPNE12  
    8 SIMAP similar genes for CPNE7 using alignment to 5 protein entries:     CPNE7_HUMAN (see all proteins):
    CPNE4    CPNE2    CPNE6    CPNE3    CPNE9    CPNE5
    CPNE1    CPNE8

    CPNE7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE7 (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166720641,2
    F--89640225(+) TGCGTG/ATATGT 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1445806761,2
    C--89640243(+) TCTCAG/TTTCCT 2 -- us2k10--------
    rs4585261,2
    C,F,A--89640267(+) CAGGGA/GAAGCT 2 -- us2k1 tfbs35Minor allele frequency- G:0.23NA EA 246
    rs110766071,2
    C--89640477(+) CCGGCA/C/GGAGGG 2 -- us2k10--------
    rs1907870711,2
    --89640538(+) AAACTA/CTGTGA 2 -- us2k10--------
    rs768251301,2
    C,F--89640731(+) AGGAGC/GTTTCG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1830194001,2
    --89640735(+) GCTTTC/TGGGTG 2 -- us2k10--------
    rs1513271051,2
    C--89640771(+) GTCTG-/GGGAAAACTGTCCCA
    GGGCTGCTGGAACCGAGC
    GGGAG
    2 -- us2k10--------
    rs1397465941,2
    --89640803(+) CGAGC-/TGGGGAG 2 -- us2k10--------
    rs606442161,2
    C--89640812(+) AGGCAC/TGGCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPNE7 (89642176 - 89663654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CPNE7 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715173CNV Deletion23290073
    esv2715177CNV Deletion23290073
    esv1000486CNV Deletion20482838
    esv1076593CNV Deletion17803354
    esv2157132CNV Deletion18987734
    esv2670517CNV Deletion23128226
    esv2672114CNV Deletion23128226
    esv2248730CNV Deletion18987734
    dgv422e201CNV Deletion23290073
    esv2715180CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE7
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605689    OMIM disorders: --

    3 diseases for CPNE7:    About MalaCards
    sporadic breast cancer    infertility    breast cancer


    CPNE7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPNE7

    Export disorders for CPNE7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CPNE7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (PubMed id 10534407)1, 2 Savino M.... Savoia A. (Genomics 1999)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    6. Genome-wide association study of tanning phenotype in a population of European ancestry. (PubMed id 19340012)4 Nan H....Han J. (J. Invest. Dermatol. 2009)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27132 HGNC: 2320 AceView: CPNE7 Ensembl:ENSG00000178773 euGenes: HUgn27132
    ECgene: CPNE7 H-InvDB: CPNE7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CPNE7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPNE7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE7 gene:
    Search GeneIP for patents involving CPNE7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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