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Aliases for CPNE7 Gene

Aliases for CPNE7 Gene

  • Copine 7 2 3
  • Copine VII 2 4 5

External Ids for CPNE7 Gene

Previous GeneCards Identifiers for CPNE7 Gene

  • GC16P080962
  • GC16P090630
  • GC16P089345
  • GC16P089385
  • GC16P088169
  • GC16P089643
  • GC16P075338
  • GC16P089646
  • GC16P089652
  • GC16P089663
  • GC16P089671

Summaries for CPNE7 Gene

Entrez Gene Summary for CPNE7 Gene

  • This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for CPNE7 Gene

CPNE7 (Copine 7) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. GO annotations related to this gene include transporter activity. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE7 Gene

  • Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE7 Gene

Genomics for CPNE7 Gene

Regulatory Elements for CPNE7 Gene

Enhancers for CPNE7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPNE7 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPNE7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE7 Gene

Chromosome:
16
Start:
89,575,768 bp from pter
End:
89,597,246 bp from pter
Size:
21,479 bases
Orientation:
Plus strand

Genomic View for CPNE7 Gene

Genes around CPNE7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE7 Gene

Proteins for CPNE7 Gene

  • Protein details for CPNE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBL6-CPNE7_HUMAN
    Recommended name:
    Copine-7
    Protein Accession:
    Q9UBL6

    Protein attributes for CPNE7 Gene

    Size:
    633 amino acids
    Molecular mass:
    70294 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE7 Gene

Proteomics data for CPNE7 Gene at MOPED

Post-translational modifications for CPNE7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPNE7 Gene

No data available for DME Specific Peptides for CPNE7 Gene

Domains & Families for CPNE7 Gene

Gene Families for CPNE7 Gene

Protein Domains for CPNE7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBL6

UniProtKB/Swiss-Prot:

CPNE7_HUMAN :
  • The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.
  • Belongs to the copine family.
Domain:
  • The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE7: view

Function for CPNE7 Gene

Molecular function for CPNE7 Gene

GENATLAS Biochemistry:
copine VII,member of the COPINE family,potential tumor suppressor,but excluded as a candidate gene in breast cancers (TSG16A,TSG16D)
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Animal Model Products

miRNA for CPNE7 Gene

miRTarBase miRNAs that target CPNE7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE7 Gene

Localization for CPNE7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE7 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455). {ECO:0000269 PubMed:21087455}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE7 Gene COMPARTMENTS Subcellular localization image for CPNE7 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CPNE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21087455
genes like me logo Genes that share ontologies with CPNE7: view

Pathways & Interactions for CPNE7 Gene

genes like me logo Genes that share pathways with CPNE7: view

Pathways by source for CPNE7 Gene

Gene Ontology (GO) - Biological Process for CPNE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10534407
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with CPNE7: view

No data available for SIGNOR curated interactions for CPNE7 Gene

Drugs & Compounds for CPNE7 Gene

(1) Drugs for CPNE7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CPNE7: view

Transcripts for CPNE7 Gene

Unigene Clusters for CPNE7 Gene

Copine VII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE7 Gene

No ASD Table

Relevant External Links for CPNE7 Gene

GeneLoc Exon Structure for
CPNE7
ECgene alternative splicing isoforms for
CPNE7

Expression for CPNE7 Gene

mRNA expression in normal human tissues for CPNE7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPNE7 Gene

This gene is overexpressed in Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), and Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for CPNE7 Gene

This gene is overexpressed in Lung (42.7), Urine (6.8), and Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE7 Gene



SOURCE GeneReport for Unigene cluster for CPNE7 Gene Hs.461775

mRNA Expression by UniProt/SwissProt for CPNE7 Gene

Q9UBL6-CPNE7_HUMAN
Tissue specificity: Expressed in the brain, testis, thymus and small intestine (PubMed:10534407, PubMed:12949241).
genes like me logo Genes that share expression patterns with CPNE7: view

Protein tissue co-expression partners for CPNE7 Gene

Primer Products

In Situ Assay Products

Orthologs for CPNE7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPNE7 35
  • 87.58 (n)
  • 89.48 (a)
CPNE7 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE7 35
  • 86.16 (n)
  • 88.69 (a)
CPNE7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne7 35
  • 84.51 (n)
  • 88.91 (a)
Cpne7 16
Cpne7 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPNE7 35
  • 91.65 (n)
  • 88.96 (a)
rat
(Rattus norvegicus)
Mammalia Cpne7 35
  • 85.22 (n)
  • 89.94 (a)
oppossum
(Monodelphis domestica)
Mammalia CPNE7 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE7 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPNE7 35
  • 83.15 (n)
  • 82.46 (a)
CPNE7 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne7 35
  • 72.71 (n)
  • 79.35 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC564556 35
  • 72.69 (n)
  • 74.56 (a)
CPNE7 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73F8A.19 37
  • 28 (a)
cpna-4 36
  • 21 (a)
ManyToMany
cpna-5 36
  • 21 (a)
ManyToMany
gem-4 36
  • 35 (a)
ManyToMany
nra-1 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CPNE7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE7 Gene

ENSEMBL:
Gene Tree for CPNE7 (if available)
TreeFam:
Gene Tree for CPNE7 (if available)

Paralogs for CPNE7 Gene

Paralogs for CPNE7 Gene

(8) SIMAP similar genes for CPNE7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPNE7: view

Variants for CPNE7 Gene

Sequence variations from dbSNP and Humsavar for CPNE7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs455527 - 89,577,593(-) CGTGA(A/G)GACCT reference, missense, utr-variant-5-prime
rs3751682 - 89,596,617(-) TTCAC(A/G)GTGTG reference, synonymous-codon, missense
rs28568523 - 89,588,712(+) CCCGC(A/G)GAACA reference, missense
rs35731090 - 89,591,252(-) GGCTT(C/T)CCCGG reference, missense
rs101151 -- 89,582,837(-) GCAGG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE7 Gene

Variant ID Type Subtype PubMed ID
nsv907357 CNV Loss 21882294
nsv428331 CNV Gain+Loss 18775914
dgv922e1 CNV Complex 17122850
nsv471118 CNV Gain 18288195
nsv907405 CNV Loss 21882294
dgv3008n71 CNV Loss 21882294
dgv3009n71 CNV Loss 21882294
nsv509639 CNV Insertion 20534489
dgv3010n71 CNV Loss 21882294
dgv3011n71 CNV Loss 21882294
nsv9477 CNV Gain+Loss 18304495
esv1000486 CNV Deletion 20482838
esv2672114 CNV Deletion 23128226
esv24151 CNV Gain 19812545
esv2157132 CNV Deletion 18987734
nsv103622 CNV Loss 16902084
dgv422e201 CNV Deletion 23290073
esv2715173 CNV Deletion 23290073
esv988408 CNV Deletion 20482838
esv1076593 CNV Deletion 17803354
nsv827847 CNV Gain 20364138
dgv423e201 CNV Deletion 23290073
esv2248730 CNV Deletion 18987734
esv33444 CNV Gain 17666407
esv24414 CNV Gain 19812545
esv2715177 CNV Deletion 23290073
esv1046929 CNV Insertion 17803354
esv2715179 CNV Deletion 23290073
esv1215908 CNV Insertion 17803354
esv2715180 CNV Deletion 23290073
esv2670517 CNV Deletion 23128226

Variation tolerance for CPNE7 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE7 Gene

HapMap Linkage Disequilibrium report
CPNE7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE7 Gene

Disorders for CPNE7 Gene

Relevant External Links for CPNE7

Genetic Association Database (GAD)
CPNE7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE7

No disorders were found for CPNE7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE7 Gene

Publications for CPNE7 Gene

  1. Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. (PMID: 21087455) Perestenko P.V. … Jeffrey McIlhinney R.A. (FEBS J. 2010) 3 4 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. CPNE7, a preameloblast-derived factor, regulates odontoblastic differentiation of mesenchymal stem cells. (PMID: 25453951) Oh H.J. … Park J.C. (Biomaterials 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for CPNE7 Gene

Sources for CPNE7 Gene

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