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Aliases for CPNE7 Gene

Aliases for CPNE7 Gene

  • Copine VII 2 3 4
  • Copine 7 3
  • Copine-7 3

External Ids for CPNE7 Gene

Previous GeneCards Identifiers for CPNE7 Gene

  • GC16P080962
  • GC16P090630
  • GC16P089345
  • GC16P089385
  • GC16P088169
  • GC16P089643
  • GC16P075338
  • GC16P089646
  • GC16P089652
  • GC16P089663
  • GC16P089671

Summaries for CPNE7 Gene

Entrez Gene Summary for CPNE7 Gene

  • This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for CPNE7 Gene

CPNE7 (Copine VII) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is CPNE2.

UniProtKB/Swiss-Prot for CPNE7 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE7 Gene

Genomics for CPNE7 Gene

Regulatory Elements for CPNE7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPNE7 Gene

89,575,768 bp from pter
89,597,246 bp from pter
21,479 bases
Plus strand

Genomic View for CPNE7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE7 Gene

Proteins for CPNE7 Gene

  • Protein details for CPNE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CPNE7 Gene

    633 amino acids
    Molecular mass:
    70294 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE7 Gene


neXtProt entry for CPNE7 Gene

Proteomics data for CPNE7 Gene at MOPED

Post-translational modifications for CPNE7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPNE7 Gene

No data available for DME Specific Peptides for CPNE7 Gene

Domains for CPNE7 Gene

Protein Domains for CPNE7 Gene


Suggested Antigen Peptide Sequences for CPNE7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UBL6
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE7: view

No data available for Gene Families for CPNE7 Gene

Function for CPNE7 Gene

Molecular function for CPNE7 Gene

GENATLAS Biochemistry: copine VII,member of the COPINE family,potential tumor suppressor,but excluded as a candidate gene in breast cancers (TSG16A,TSG16D)
UniProtKB/Swiss-Prot Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

Gene Ontology (GO) - Molecular Function for CPNE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10534407
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CPNE7: view

Animal Model Products

CRISPR Products

miRNA for CPNE7 Gene

miRTarBase miRNAs that target CPNE7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPNE7 Gene

Localization for CPNE7 Gene

Subcellular locations from

Jensen Localization Image for CPNE7 Gene COMPARTMENTS Subcellular localization image for CPNE7 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CPNE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE7 Gene

Pathways for CPNE7 Gene

SuperPathways for CPNE7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10534407
GO:0006644 phospholipid metabolic process TAS --
GO:0006810 transport TAS 10534407
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with CPNE7: view

No data available for Pathways by source for CPNE7 Gene

Compounds for CPNE7 Gene

(1) HMDB Compounds for CPNE7 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CPNE7: view

Transcripts for CPNE7 Gene

Unigene Clusters for CPNE7 Gene

Copine VII:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CPNE7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE7 Gene

No ASD Table

Relevant External Links for CPNE7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE7 Gene

mRNA expression in normal human tissues for CPNE7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPNE7 Gene

This gene is overexpressed in Brain - Cortex (5.1), Brain - Anterior cingulate cortex (BA24) (4.6), and Pituitary (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE7 Gene

SOURCE GeneReport for Unigene cluster for CPNE7 Gene Hs.461775

genes like me logo Genes that share expressions with CPNE7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPNE7 Gene

Orthologs for CPNE7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPNE7 35
  • 91.65 (n)
  • 88.96 (a)
(Bos Taurus)
Mammalia CPNE7 35
  • 87.58 (n)
  • 89.48 (a)
CPNE7 36
  • 82 (a)
(Canis familiaris)
Mammalia CPNE7 35
  • 86.16 (n)
  • 88.69 (a)
CPNE7 36
  • 89 (a)
(Mus musculus)
Mammalia Cpne7 35
  • 84.51 (n)
  • 88.91 (a)
Cpne7 16
Cpne7 36
  • 90 (a)
(Monodelphis domestica)
Mammalia CPNE7 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE7 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Cpne7 35
  • 85.22 (n)
  • 89.94 (a)
(Gallus gallus)
Aves CPNE7 35
  • 83.15 (n)
  • 82.46 (a)
CPNE7 36
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
-- 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne7 35
  • 72.71 (n)
  • 79.35 (a)
(Danio rerio)
Actinopterygii CPNE7 36
  • 75 (a)
LOC564556 35
  • 72.69 (n)
  • 74.56 (a)
(Caenorhabditis elegans)
Secernentea cpna-4 36
  • 21 (a)
cpna-5 36
  • 21 (a)
gem-4 36
  • 35 (a)
nra-1 36
  • 35 (a)
Y73F8A.19 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for CPNE7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE7 Gene

Gene Tree for CPNE7 (if available)
Gene Tree for CPNE7 (if available)

Paralogs for CPNE7 Gene

Paralogs for CPNE7 Gene

Selected SIMAP similar genes for CPNE7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPNE7: view

Variants for CPNE7 Gene

Sequence variations from dbSNP and Humsavar for CPNE7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs101151 -- 89,582,837(-) GCAGG(C/T)GTGTG intron-variant
rs173290 -- 89,580,434(-) TGTTC(C/T)GTGTG intron-variant
rs181295 -- 89,581,297(-) GGGAT(A/G)TTCTG intron-variant
rs183040 -- 89,581,268(-) GTTCC(A/G)TGTGA intron-variant
rs189528 -- 89,580,164(-) GGTGA(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE7 Gene

Variant ID Type Subtype PubMed ID
nsv907357 CNV Loss 21882294
nsv428331 CNV Gain+Loss 18775914
dgv922e1 CNV Complex 17122850
nsv471118 CNV Gain 18288195
nsv907405 CNV Loss 21882294
dgv3008n71 CNV Loss 21882294
dgv3009n71 CNV Loss 21882294
nsv509639 CNV Insertion 20534489
dgv3010n71 CNV Loss 21882294
dgv3011n71 CNV Loss 21882294
nsv9477 CNV Gain+Loss 18304495
esv1000486 CNV Deletion 20482838
esv2672114 CNV Deletion 23128226
esv24151 CNV Gain 19812545
esv2157132 CNV Deletion 18987734
nsv103622 CNV Loss 16902084
dgv422e201 CNV Deletion 23290073
esv2715173 CNV Deletion 23290073
esv988408 CNV Deletion 20482838
esv1076593 CNV Deletion 17803354
nsv827847 CNV Gain 20364138
dgv423e201 CNV Deletion 23290073
esv2248730 CNV Deletion 18987734
esv33444 CNV Gain 17666407
esv24414 CNV Gain 19812545
esv2715177 CNV Deletion 23290073
esv1046929 CNV Insertion 17803354
esv2715179 CNV Deletion 23290073
esv1215908 CNV Insertion 17803354
esv2715180 CNV Deletion 23290073
esv2670517 CNV Deletion 23128226

Relevant External Links for CPNE7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE7 Gene

Disorders for CPNE7 Gene

Relevant External Links for CPNE7

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CPNE7: view

No data available for UniProtKB/Swiss-Prot for CPNE7 Gene

Publications for CPNE7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (PMID: 10534407) Savino M. … Savoia A. (Genomics 1999) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for CPNE7 Gene

Sources for CPNE7 Gene

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