Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPNE6 Gene

Aliases for CPNE6 Gene

  • Copine 6 2 3
  • Copine VI (Neuronal) 2 3 5
  • N-Copine 3 4
  • Neuronal-Copine 4
  • Copine VI 4

External Ids for CPNE6 Gene

Previous GeneCards Identifiers for CPNE6 Gene

  • GC14P021913
  • GC14P018328
  • GC14P022530
  • GC14P023609
  • GC14P024540
  • GC14P004655

Summaries for CPNE6 Gene

Entrez Gene Summary for CPNE6 Gene

  • This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

GeneCards Summary for CPNE6 Gene

CPNE6 (Copine 6) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is CPNE2.

UniProtKB/Swiss-Prot for CPNE6 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for CPNE6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE6 Gene

Genomics for CPNE6 Gene

Regulatory Elements for CPNE6 Gene

Genomic Location for CPNE6 Gene

Chromosome:
14
Start:
24,070,837 bp from pter
End:
24,078,100 bp from pter
Size:
7,264 bases
Orientation:
Plus strand

Genomic View for CPNE6 Gene

Genes around CPNE6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE6 Gene

Proteins for CPNE6 Gene

  • Protein details for CPNE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95741-CPNE6_HUMAN
    Recommended name:
    Copine-6
    Protein Accession:
    O95741
    Secondary Accessions:
    • B2RAG6
    • B7Z1M3
    • D3DS55
    • F5GXN1
    • Q53HA6
    • Q8WVG1

    Protein attributes for CPNE6 Gene

    Size:
    557 amino acids
    Molecular mass:
    61991 Da
    Quaternary structure:
    • Interacts (via second C2 domain) with OS9 (via C-terminus); this interaction occurs in a calcium-dependent manner in vitro (By similarity). May interact with NECAB1 (PubMed:12044471).

    Alternative splice isoforms for CPNE6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE6 Gene

Proteomics data for CPNE6 Gene at MOPED

Post-translational modifications for CPNE6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CPNE6 Gene

Domains & Families for CPNE6 Gene

Gene Families for CPNE6 Gene

Protein Domains for CPNE6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE6 Gene

Graphical View of Domain Structure for InterPro Entry

O95741

UniProtKB/Swiss-Prot:

CPNE6_HUMAN :
  • The C2 domain 1 binds phospholipids in a calcium-independent manner and is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 binds phospholipids in a calcium-dependent manner and is necessary for calcium-mediated translocation and association to the plasma membrane. The linker region contributes to the calcium-dependent translocation and association to the plasma membrane. The VWFA domain is necessary for association with intracellular clathrin-coated vesicles in a calcium-dependent manner.
  • Belongs to the copine family.
Domain:
  • The C2 domain 1 binds phospholipids in a calcium-independent manner and is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 binds phospholipids in a calcium-dependent manner and is necessary for calcium-mediated translocation and association to the plasma membrane. The linker region contributes to the calcium-dependent translocation and association to the plasma membrane. The VWFA domain is necessary for association with intracellular clathrin-coated vesicles in a calcium-dependent manner.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE6: view

Function for CPNE6 Gene

Molecular function for CPNE6 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology (GO) - Molecular Function for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with CPNE6: view

Phenotypes for CPNE6 Gene

genes like me logo Genes that share phenotypes with CPNE6: view

Animal Model Products

miRNA for CPNE6 Gene

miRTarBase miRNAs that target CPNE6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE6 Gene

Localization for CPNE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE6 Gene

Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner. {ECO:0000250 UniProtKB:Q9Z140}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE6 Gene COMPARTMENTS Subcellular localization image for CPNE6 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
endosome 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0030425 dendrite IEA,ISS --
GO:0045334 clathrin-coated endocytic vesicle IEA --
genes like me logo Genes that share ontologies with CPNE6: view

Pathways & Interactions for CPNE6 Gene

genes like me logo Genes that share pathways with CPNE6: view

Pathways by source for CPNE6 Gene

Gene Ontology (GO) - Biological Process for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0007399 nervous system development TAS 9645480
GO:0016192 vesicle-mediated transport TAS 9645480
GO:1903861 positive regulation of dendrite extension IDA 23999003
genes like me logo Genes that share ontologies with CPNE6: view

No data available for SIGNOR curated interactions for CPNE6 Gene

Drugs & Compounds for CPNE6 Gene

(1) Drugs for CPNE6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(124) Additional Compounds for CPNE6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CPNE6: view

Transcripts for CPNE6 Gene

Unigene Clusters for CPNE6 Gene

Copine VI (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:
SP7: - -
SP8: -
SP9:

Relevant External Links for CPNE6 Gene

GeneLoc Exon Structure for
CPNE6
ECgene alternative splicing isoforms for
CPNE6

Expression for CPNE6 Gene

mRNA expression in normal human tissues for CPNE6 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE6 Gene

This gene is overexpressed in Brain - Hippocampus (x7.2), Brain - Amygdala (x6.1), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for CPNE6 Gene

This gene is overexpressed in Brain (18.9), Spinal cord (17.4), Retina (11.8), Frontal cortex (9.6), and Seminal vesicle (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPNE6 Gene



SOURCE GeneReport for Unigene cluster for CPNE6 Gene Hs.6132

mRNA Expression by UniProt/SwissProt for CPNE6 Gene

O95741-CPNE6_HUMAN
Tissue specificity: Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with CPNE6: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CPNE6 Gene

Orthologs for CPNE6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE6 35
  • 99.56 (n)
  • 99.35 (a)
CPNE6 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPNE6 36
  • 98 (a)
OneToOne
CPNE6 35
  • 91.32 (n)
  • 97.67 (a)
dog
(Canis familiaris)
Mammalia CPNE6 35
  • 92.34 (n)
  • 98.2 (a)
CPNE6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne6 16
Cpne6 36
  • 98 (a)
OneToOne
Cpne6 35
  • 90.13 (n)
  • 97.85 (a)
oppossum
(Monodelphis domestica)
Mammalia CPNE6 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE6 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne6 35
  • 88.63 (n)
  • 96.41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y73F8A.19 37
  • 23 (a)
cpna-4 36
  • 20 (a)
ManyToMany
cpna-5 36
  • 21 (a)
ManyToMany
gem-4 36
  • 32 (a)
ManyToMany
nra-1 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for CPNE6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPNE6 Gene

ENSEMBL:
Gene Tree for CPNE6 (if available)
TreeFam:
Gene Tree for CPNE6 (if available)

Paralogs for CPNE6 Gene

Paralogs for CPNE6 Gene

genes like me logo Genes that share paralogs with CPNE6: view

Variants for CPNE6 Gene

Sequence variations from dbSNP and Humsavar for CPNE6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7151831 -- 24,073,438(+) TCCAG(C/G)ACAGG intron-variant
rs11557515 -- 24,074,351(+) CCTAC(A/G)AGCTG reference, missense, utr-variant-5-prime
rs11557516 -- 24,073,536(+) CAGCC(A/C)TGTCT reference, missense, utr-variant-5-prime
rs11846787 -- 24,076,023(+) CCACA(C/T)CATTA intron-variant
rs12883935 -- 24,071,643(+) CCAGG(A/T)GAGCC splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE6 Gene

Variant ID Type Subtype PubMed ID
nsv516023 CNV Loss 19592680

Variation tolerance for CPNE6 Gene

Residual Variation Intolerance Score: 9.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 31.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE6 Gene

HapMap Linkage Disequilibrium report
CPNE6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE6 Gene

Disorders for CPNE6 Gene

Relevant External Links for CPNE6

Genetic Association Database (GAD)
CPNE6
Human Genome Epidemiology (HuGE) Navigator
CPNE6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE6

No disorders were found for CPNE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE6 Gene

Publications for CPNE6 Gene

  1. N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. (PMID: 9645480) Nakayama T. … Kuwajima G. (FEBS Lett. 1998) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo J.C. … Yoon T.J. (J. Dermatol. Sci. 2013) 3

Products for CPNE6 Gene

Sources for CPNE6 Gene

Back to Top

Content