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Aliases for CPNE6 Gene

Aliases for CPNE6 Gene

  • Copine VI (Neuronal) 2 3
  • N-Copine 3 4
  • Neuronal-Copine 4
  • Copine VI 4
  • Copine-6 3

External Ids for CPNE6 Gene

Previous GeneCards Identifiers for CPNE6 Gene

  • GC14P021913
  • GC14P018328
  • GC14P022530
  • GC14P023609
  • GC14P024540
  • GC14P004655

Summaries for CPNE6 Gene

Entrez Gene Summary for CPNE6 Gene

  • This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

GeneCards Summary for CPNE6 Gene

CPNE6 (Copine VI (Neuronal)) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE6 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May have a role in synaptic plasticity (By similarity).

Gene Wiki entry for CPNE6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE6 Gene

Genomics for CPNE6 Gene

Regulatory Elements for CPNE6 Gene

Genomic Location for CPNE6 Gene

Start:
24,070,837 bp from pter
End:
24,078,100 bp from pter
Size:
7,264 bases
Orientation:
Plus strand

Genomic View for CPNE6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE6 Gene

Proteins for CPNE6 Gene

  • Protein details for CPNE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95741-CPNE6_HUMAN
    Recommended name:
    Copine-6
    Protein Accession:
    O95741
    Secondary Accessions:
    • B2RAG6
    • B7Z1M3
    • D3DS55
    • F5GXN1
    • Q53HA6
    • Q8WVG1

    Protein attributes for CPNE6 Gene

    Size:
    557 amino acids
    Molecular mass:
    61991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE6 Gene

Proteomics data for CPNE6 Gene at MOPED

Post-translational modifications for CPNE6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPNE6 Gene

Domains for CPNE6 Gene

Protein Domains for CPNE6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE6 Gene

Graphical View of Domain Structure for InterPro Entry

O95741

UniProtKB/Swiss-Prot:

CPNE6_HUMAN :
  • O95741
Domain:
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE6: view

No data available for Gene Families for CPNE6 Gene

Function for CPNE6 Gene

Molecular function for CPNE6 Gene

UniProtKB/Swiss-Prot Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May have a role in synaptic plasticity (By similarity).

Gene Ontology (GO) - Molecular Function for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005215 transporter activity TAS 9645480
GO:0005509 calcium ion binding TAS 9645480
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CPNE6: view

Phenotypes for CPNE6 Gene

GenomeRNAi human phenotypes for CPNE6:
genes like me logo Genes that share phenotypes with CPNE6: view

Animal Model Products

CRISPR Products

miRNA for CPNE6 Gene

miRTarBase miRNAs that target CPNE6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPNE6 Gene

Localization for CPNE6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE6 Gene COMPARTMENTS Subcellular localization image for CPNE6 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE6 Gene

Pathways for CPNE6 Gene

SuperPathways for CPNE6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9645480
GO:0006644 phospholipid metabolic process TAS --
GO:0007268 synaptic transmission TAS 9645480
GO:0007399 nervous system development TAS 9645480
GO:0016192 vesicle-mediated transport TAS 9645480
genes like me logo Genes that share ontologies with CPNE6: view

No data available for Pathways by source for CPNE6 Gene

Compounds for CPNE6 Gene

(125) HMDB Compounds for CPNE6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
PS(14:0/14:0)
  • Phosphatidylserine(14:0/14:0)
Not Available
PS(14:0/14:1(9Z))
  • Phosphatidylserine(14:0/14:1n5)
Not Available
PS(14:0/16:0)
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
PS(14:0/16:1(9Z))
  • PS(14:0/16:1n7)
Not Available
genes like me logo Genes that share compounds with CPNE6: view

Transcripts for CPNE6 Gene

Unigene Clusters for CPNE6 Gene

Copine VI (neuronal):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:
SP7: - -
SP8: -
SP9:

Relevant External Links for CPNE6 Gene

GeneLoc Exon Structure for
CPNE6
ECgene alternative splicing isoforms for
CPNE6

Expression for CPNE6 Gene

mRNA expression in normal human tissues for CPNE6 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE6 Gene

This gene is overexpressed in Brain - Hippocampus (7.2), Brain - Amygdala (6.1), Brain - Cortex (4.7), and Brain - Anterior cingulate cortex (BA24) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CPNE6 Gene

SOURCE GeneReport for Unigene cluster for CPNE6 Gene Hs.6132

genes like me logo Genes that share expressions with CPNE6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPNE6 Gene

Orthologs for CPNE6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE6 35
  • 99.56 (n)
  • 99.35 (a)
CPNE6 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPNE6 35
  • 91.32 (n)
  • 97.67 (a)
CPNE6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE6 35
  • 92.34 (n)
  • 98.2 (a)
CPNE6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne6 35
  • 90.13 (n)
  • 97.85 (a)
Cpne6 16
Cpne6 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPNE6 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE6 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne6 35
  • 88.63 (n)
  • 96.41 (a)
worm
(Caenorhabditis elegans)
Secernentea cpna-4 36
  • 20 (a)
ManyToMany
cpna-5 36
  • 21 (a)
ManyToMany
gem-4 36
  • 32 (a)
ManyToMany
nra-1 36
  • 34 (a)
ManyToMany
Y73F8A.19 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for CPNE6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPNE6 Gene

ENSEMBL:
Gene Tree for CPNE6 (if available)
TreeFam:
Gene Tree for CPNE6 (if available)

Paralogs for CPNE6 Gene

Paralogs for CPNE6 Gene

genes like me logo Genes that share paralogs with CPNE6: view

Variants for CPNE6 Gene

Sequence variations from dbSNP and Humsavar for CPNE6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2025256 -- 24,074,664(-) TGTGT(C/T)TTCTT intron-variant
rs2070341 -- 24,076,166(-) GAGGC(A/G)GTGAA reference, synonymous-codon
rs2070342 -- 24,076,157(-) AAGTC(A/G)ATGGC synonymous-codon, reference
rs2070343 -- 24,074,599(-) CAGAC(C/G)AGCTG synonymous-codon, reference
rs2070345 -- 24,076,775(-) CTCCC(C/G)TCGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE6 Gene

Variant ID Type Subtype PubMed ID
nsv516023 CNV Loss 19592680

Relevant External Links for CPNE6 Gene

HapMap Linkage Disequilibrium report
CPNE6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE6 Gene

Disorders for CPNE6 Gene

Relevant External Links for CPNE6

Genetic Association Database (GAD)
CPNE6
Human Genome Epidemiology (HuGE) Navigator
CPNE6
genes like me logo Genes that share disorders with CPNE6: view

No data available for UniProtKB/Swiss-Prot for CPNE6 Gene

Publications for CPNE6 Gene

  1. N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. (PMID: 9645480) Nakayama T. … Kuwajima G. (FEBS Lett. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for CPNE6 Gene

Sources for CPNE6 Gene

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