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CPNE6 Gene

protein-coding   GIFtS: 55
GCID: GC14P024540

Copine VI (Neuronal)

  Search for CPNE6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine VI (Neuronal)1 2
N-copine2 3
copine-62
Neuronal-copine3
Copine VI3

External Ids:    HGNC: 23191   Entrez Gene: 93622   Ensembl: ENSG000001008847   OMIM: 6056885   UniProtKB: O957413   

Export aliases for CPNE6 gene to outside databases

Previous GC identifers: GC14P021913 GC14P018328 GC14P022530 GC14P023609 GC14P004655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE6 Gene:
This gene encodes a member of the copine family. Members of this family are calcium-dependent,
phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their
domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This
protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von
Willebrand factor A domain. It may have a role in synaptic plasticity. (provided by RefSeq, Jul 2013)

GeneCards Summary for CPNE6 Gene:
CPNE6 (copine VI (neuronal)) is a protein-coding gene. GO annotations related to this gene include phosphatidylserine binding and calcium ion binding. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE6_HUMAN, O95741
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May
have a role in synaptic plasticity (By similarity)

Gene Wiki entry for CPNE6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE6 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE6 promoter sequence
   Search Chromatin IP Primers for CPNE6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

CPNE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024540:  view genomic region     (about GC identifiers)

Start:
24,540,046 bp from pter      End:
24,547,309 bp from pter
Size:
7,264 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPNE6_HUMAN, O95741 (See protein sequence)
Recommended Name: Copine-6  
Size: 557 amino acids; 61991 Da
Secondary accessions: B2RAG6 D3DS55 Q53HA6 Q8WVG1

Explore the universe of human proteins at neXtProt for CPNE6: NX_O95741

Explore proteomics data for CPNE6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPNE6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001267487.1  NP_006023.1  

    ENSEMBL proteins: 
     ENSP00000380211   ENSP00000454192   ENSP00000454093   ENSP00000453483   ENSP00000454075  
     ENSP00000454166   ENSP00000453352   ENSP00000453326   ENSP00000452826   ENSP00000453261  
     ENSP00000452884   ENSP00000454172   ENSP00000452653   ENSP00000440077   ENSP00000216775  

    CPNE6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPNE6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry O95741

    ProtoNet protein and cluster: O95741

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE6_HUMAN, O95741
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with CPNE6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE6_HUMAN, O95741
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May
    have a role in synaptic plasticity (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IEA--
    GO:0005215transporter activity TAS9645480
    GO:0005509calcium ion binding TAS9645480
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CPNE6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CPNE6:
     Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE6

    miRNA
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    miRTarBase miRNAs that target CPNE6:
    hsa-mir-197-3p (MIRT003821), hsa-mir-335-5p (MIRT017193)

    Block miRNA regulation of human, mouse, rat CPNE6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CPNE6
    SwitchGear 3'UTR luciferase reporter plasmidCPNE6 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with CPNE6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE6
    Interactions:

        Search GeneGlobe Interaction Network for CPNE6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for CPNE6 (O957412, 3 ENSP000002167754) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271003 I2D: score=2 
    SMN2Q166372, 3MINT-8271003 I2D: score=2 
    ANXA7P200732, 3MINT-8248197 I2D: score=2 
    CDKN1AP389362, 3MINT-8251747 I2D: score=2 
    GRB7Q144512, 3MINT-8256646 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9645480
    GO:0007268synaptic transmission TAS9645480
    GO:0007399nervous system development TAS9645480
    GO:0016192vesicle-mediated transport TAS9645480

    Find genes that share ontologies with CPNE6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE6

    Selected HMDB Compounds for CPNE6 (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPNE6 gene (2 alternative transcripts): 
    NM_001280558.1  NM_006032.3  

    Unigene Cluster for CPNE6:

    Copine VI (neuronal)
    Hs.6132  [show with all ESTs]
    Unigene Representative Sequence: AL137688
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000397016(uc010tnv.2 uc001wll.3) ENST00000560356 ENST00000558450
    ENST00000558995(uc001wlm.3) ENST00000559778 ENST00000560761 ENST00000557889
    ENST00000558541 ENST00000558859 ENST00000560092 ENST00000559197 ENST00000560828
    ENST00000560884 ENST00000558795 ENST00000559207 ENST00000460657 ENST00000557829(uc001wln.3)
    ENST00000560845
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPNE6
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    GenScript: all cDNA clones in your preferred vector: CPNE6 (NM_006032)
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    OriGene qPCR primer pairs and template standards for CPNE6
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      QuantiFast Probe-based Assays in human, mouse, rat CPNE6

    Additional mRNA sequence: 

    AB009288.1 AK125195.1 AK222675.1 AK293655.1 AK294460.1 AK314182.1 AL050397.1 AL137688.1 
    BC018046.1 

    13 DOTS entries:

    DT.310911  DT.95172092  DT.95172095  DT.120757432  DT.120757422  DT.120757419  DT.75118801  DT.120757417 
    DT.91659560  DT.100806112  DT.120757414  DT.95172091  DT.95172094 

    Selected AceView cDNA sequences (see all 72):

    AI493694 CR598214 AI628393 AK125195 T08617 NM_006032 BX451552 BX419926 
    BI821045 BG714686 BI551073 T33805 BI552844 CB152059 BG714305 BI547593 
    AW161151 CD243212 BI548412 BM545273 BP348888 AL036024 BI914650 BI553449 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPNE6 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                                                            
    SP2:                                                              -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                              -     -     -                                                                                 


    ECgene alternative splicing isoforms for CPNE6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGCTGG
    CPNE6 Expression
    About this image


    CPNE6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Cerebral Cortex
             entorhinal cortex layer ii stellate island cells   
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    CPNE6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6132
        Custom PCR Arrays for CPNE6
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    QuantiFast Probe-based Assays in human, mouse, rat CPNE6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPNE6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne61 , 5 copine VI1, 5 90.13(n)1
    97.85(a)1
      14 (28.19 cM)5
    128911  NM_009947.31  NP_034077.11 
     555104455 
    worm
    (Caenorhabditis elegans)
    Secernentea Y73F8A.193   -- 23(a)   IV(15361756-15368155)   --


    ENSEMBL Gene Tree for CPNE6 (if available)
    TreeFam Gene Tree for CPNE6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE6 gene
    CPNE92  CPNE22  CPNE32  CPNE52  CPNE82  CPNE42  CPNE72  CPNE12  
    9 SIMAP similar genes for CPNE6 using alignment to 15 protein entries:     CPNE6_HUMAN (see all proteins):
    CPNE4    CPNE7    CPNE2    CPNE8    CPNE9    CPNE3
    CPNE1    CPNE5    DKFZp666C234

    Find genes that share paralogs with CPNE6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE6 (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434281101,2
    Cuntested15540062(+) CTGGCC/TCTTGA 2 A syn10--------
    rs736030541,2
    C--5536198(+) GGACTG/CTCTCC 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1502010551,2
    --5536234(+) AATCAA/TCGCCT 1 -- us2k10--------
    rs1386302901,2
    C--5536236(+) TCATCA/GCCTGC 1 -- us2k10--------
    rs1445215001,2
    --5536322(+) ACAGTA/GGAGAA 1 -- us2k10--------
    rs756574981,2
    C,F--5536351(+) AGGGAT/CAGACT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs2014671511,2
    C--5536423(+) GTCCCA/CAAGCC 1 -- us2k10--------
    rs1380184141,2
    --5536494(+) GAAACC/TAACAC 1 -- us2k10--------
    rs736030561,2
    C,F--5536543(+) AGCCCC/TAGTGT 1 -- us2k13Minor allele frequency- T:0.05WA 122
    rs1438750871,2
    C--5536589(+) TGTGT-/GCATGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPNE6 (24540046 - 24547309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CPNE6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516023CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE6
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605688    OMIM disorders: --


    Find genes that share disorders with CPNE6           About GenesLikeMe

    Genetic Association Database (GAD): CPNE6
    Human Genome Epidemiology (HuGE) Navigator: CPNE6 (2 documents)

    Export disorders for CPNE6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE6 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CPNE6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. (PubMed id 9645480)1, 2, 3 Nakayama T.... Kuwajima G. (FEBS Lett. 1998)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins. (PubMed id 12440769)1 Tomsig J.L. and Creutz C.E. (Cell. Mol. Life Sci. 2002)
    9. Characterization of human copine III as a phosphoprotein with associated kinase activity. (PubMed id 11041869)1 Caudell E.G....Grimm E.A. (Biochemistry 2000)
    10. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. (PubMed id 10403379)1 Nakayama T....Sakata T. (FEBS Lett. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9362 HGNC: 2319 AceView: CPNE6 Ensembl:ENSG00000100884 euGenes: HUgn9362
    ECgene: CPNE6 H-InvDB: CPNE6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE6 gene:
    Search GeneIP for patents involving CPNE6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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