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CPNE5 Gene

protein-coding   GIFtS: 51
GCID: GC06M036755

Copine V

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine V1 2 3
CPN52 5
COPN52
copine-52
KIAA15993

External Ids:    HGNC: 23181   Entrez Gene: 576992   Ensembl: ENSG000001247727   OMIM: 6042095   UniProtKB: Q9HCH33   

Export aliases for CPNE5 gene to outside databases

Previous GC identifers: GC06M036710 GC06M036816 GC06M036426


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE5 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two
N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis
identified multiple alternatively spliced transcript variants but their full-length natures could not be
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPNE5 Gene:
CPNE5 (copine V) is a protein-coding gene. Diseases associated with CPNE5 include infertility, and neuronitis. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE5_HUMAN, Q9HCH3
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE5 gene promoter:
         NF-1   AML1a   HTF   GATA-1   E47   MEF-2A   c-Rel   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPNE5 promoter sequence
   Search Chromatin IP Primers for CPNE5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

CPNE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036755:  view genomic region     (about GC identifiers)

Start:
36,708,552 bp from pter      End:
36,807,778 bp from pter
Size:
99,227 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CPNE5_HUMAN, Q9HCH3 (See protein sequence)
Recommended Name: Copine-5  
Size: 593 amino acids; 65734 Da
Sequence caution: Sequence=BAB13425.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for CPNE5: NX_Q9HCH3

Explore proteomics data for CPNE5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPNE5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065990.1  
    ENSEMBL proteins: 
     ENSP00000244751   ENSP00000376885  

    CPNE5 Human Recombinant Protein Products:

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    CPNE5 Assay Products:

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    Cloud-Clone Corp. ELISAs for CPNE5
    Cloud-Clone Corp. CLIAs for CPNE5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9HCH3

    ProtoNet protein and cluster: Q9HCH3

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB002035 Von Willebrand factor type A domain signature
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE5_HUMAN, Q9HCH3
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE5_HUMAN, Q9HCH3
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Genatlas biochemistry entry for CPNE5:
    copine 5,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane
    trafficking,expressed in several tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    CPNE5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPNE5:
     Increased G2M DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPNE5:
    hsa-mir-122-5p (MIRT023240), hsa-mir-148b-3p (MIRT019270), hsa-mir-335-5p (MIRT016953)

    Block miRNA regulation of human, mouse, rat CPNE5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE5 (see all 14):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4328 hsa-miR-548b-3p hsa-miR-486-3p hsa-miR-3133 hsa-miR-3692 hsa-miR-23b*
    SwitchGear 3'UTR luciferase reporter plasmidCPNE5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPNE5
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE5

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CPNE5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE5 (NM_020939)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CPNE5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CPNE5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE5
    Interactions:

        Search GeneGlobe Interaction Network for CPNE5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CPNE5 (ENSP000002447514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CPNE5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE5

    1 HMDB Compound for CPNE5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPNE5 gene: 
    NM_020939.1  

    Unigene Cluster for CPNE5:

    Copine V
    Hs.657869  [show with all ESTs]
    Unigene Representative Sequence: AB046819
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459703 ENST00000244751(uc003omr.1 uc003oms.1) ENST00000493411
    ENST00000393189(uc003omp.1 uc010jwn.1 uc003omq.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE5 (see all 14):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4328 hsa-miR-548b-3p hsa-miR-486-3p hsa-miR-3133 hsa-miR-3692 hsa-miR-23b*
    SwitchGear 3'UTR luciferase reporter plasmidCPNE5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPNE5
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE5
    Clone
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    OriGene clones in human, mouse for CPNE5 (see all 8)
    OriGene ORF clones in mouse, rat for CPNE5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE5 (NM_020939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE5
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE5
      QuantiFast Probe-based Assays in human, mouse, rat CPNE5

    Additional mRNA sequence: 

    AB046819.1 BC012765.2 BC036840.1 BC053872.1 

    14 DOTS entries:

    DT.209642  DT.99976680  DT.101983136  DT.40277499  DT.95161624  DT.99933253  DT.91950731  DT.121369636 
    DT.40126474  DT.100745079  DT.95358542  DT.97848838  DT.406173  DT.95208386 

    Selected AceView cDNA sequences (see all 156):

    CB852991 AI382977 BM703923 C01544 AA731433 BQ065904 BQ063131 BX102637 
    BC012765 BQ027323 BQ066288 BC036840 BQ057887 AW268865 BM927433 AA465140 
    AB046819 BQ057546 BQ054778 AW268855 BX118391 BQ054669 BQ063859 NM_020939 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPNE5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
    SP1:              -                                         -     -                             -                             -                                 
    SP2:              -                                         -                                                                                                   
    SP3:              -                                                                                                                                             
    SP4:                                                                                                                    -     -                                 
    SP5:                                                                                                                    -     -                                 

    ExUns: 23a · 23b ^ 24 ^ 25
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for CPNE5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE5 expression in normal human tissues (normalized intensities)      CPNE5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPNE5 Expression
    About this image


    CPNE5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Lymph (Hematopoietic System)
    CPNE5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657869
        Custom PCR Arrays for CPNE5
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPNE5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne51 , 5 copine V1, 5 89.54(n)1
    97.98(a)1
      17 (15.14 cM)5
    2400581  NM_153166.21  NP_694806.11 
     291565505 
    chicken
    (Gallus gallus)
    Aves CPNE56
    copine V
    79(a)
    1 ↔ 1
    AADN03012208.1(21-1714)
    lizard
    (Anolis carolinensis)
    Reptilia CPNE56
    copine V
    82(a)
    1 ↔ 1
    4(105280620-105377562)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323662 Xenopus laevis transcribed sequence with moderate similarity more 74.9(n)    BJ632009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641942 similar to copine V 79.58(n)   394003  BC054636.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nra-11 nra-1 50.69(n)
    48.49(a)
      178508  NM_182304.3  NP_872104.1 


    ENSEMBL Gene Tree for CPNE5 (if available)
    TreeFam Gene Tree for CPNE5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE5 gene
    CPNE92  CPNE82  CPNE22  CPNE42  CPNE62  CPNE72  CPNE32  CPNE12  
    9 SIMAP similar genes for CPNE5 using alignment to 2 protein entries:     CPNE5_HUMAN (see all proteins):
    DKFZp666C234    CPNE9    CPNE8    CPNE4    CPNE1    CPNE3
    CPNE2    CPNE6    CPNE7

    CPNE5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE5 (see all 2414)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769747721,2
    C,F--36708063(+) GGCCTC/TGCTCT 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs734123011,2
    C--36708110(+) CTTTGC/TGCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs69098211,2
    C,F,H--36708164(+) gctccC/Ttgtct 1 -- ds500110Minor allele frequency- T:0.11NS EA CSA WA 1212
    rs23956621,2
    C,F,A,H--36708196(+) AACCAC/TGACCT 1 -- ds500113Minor allele frequency- T:0.48NS EA NA WA CSA 788
    rs1456522391,2
    --36708245(+) TCACCC/TTCCTT 1 -- ds50010--------
    rs1488986071,2
    C--36708423(+) CAGAGA/C/TGTGGC 1 -- ds50010--------
    rs779529361,2
    F--36708430(+) TGGCAC/TGTGGC 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs69331101,2
    C,F,H--36708467(+) AACAAT/CTGAAG 1 -- ds50016Minor allele frequency- C:0.01NS EA CSA 424
    rs455965371,2
    C--36708512(+) GCAACA/GTCAGT 1 -- ds50010--------
    rs1409573581,2
    --36708547(+) AACTTC/GGTGCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CPNE5 (36708552 - 36807778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CPNE5 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731931CNV Deletion23290073
    esv991181CNV Deletion20482838
    nsv819609CNV Loss19587683
    nsv885809CNV Loss21882294
    nsv885814CNV Loss21882294
    nsv885813CNV Loss21882294
    dgv6835n71CNV Loss21882294
    nsv5262CNV Loss18451855
    nsv5261CNV Loss18451855
    nsv818413CNV Loss17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE5
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604209    OMIM disorders: --

    2 diseases for CPNE5:    About MalaCards
    infertility    neuronitis


    CPNE5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPNE5
    Human Genome Epidemiology (HuGE) Navigator: CPNE5 (1 document)

    Export disorders for CPNE5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CPNE5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (J. Biol. Chem. 1998)
    5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57699 HGNC: 2318 AceView: CPNE5 Ensembl:ENSG00000124772 euGenes: HUgn57699
    ECgene: CPNE5 H-InvDB: CPNE5

    (According to HUGE)
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    HUGE: KIAA1599

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE5 gene:
    Search GeneIP for patents involving CPNE5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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