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Aliases for CPNE5 Gene

Aliases for CPNE5 Gene

  • Copine 5 2 3
  • Copine V 2 3 4 5
  • KIAA1599 4
  • COPN5 3
  • CPN5 3

External Ids for CPNE5 Gene

Previous GeneCards Identifiers for CPNE5 Gene

  • GC06M036710
  • GC06M036755
  • GC06M036816
  • GC06M036426

Summaries for CPNE5 Gene

Entrez Gene Summary for CPNE5 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015]

GeneCards Summary for CPNE5 Gene

CPNE5 (Copine 5) is a Protein Coding gene. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE5 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE5 Gene

Genomics for CPNE5 Gene

Regulatory Elements for CPNE5 Gene

Enhancers for CPNE5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPNE5 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPNE5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE5 Gene

36,740,772 bp from pter
36,840,002 bp from pter
99,231 bases
Minus strand

Genomic View for CPNE5 Gene

Genes around CPNE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE5 Gene

Proteins for CPNE5 Gene

  • Protein details for CPNE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7Z6C8

    Protein attributes for CPNE5 Gene

    593 amino acids
    Molecular mass:
    65734 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13425.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CPNE5 Gene


neXtProt entry for CPNE5 Gene

Proteomics data for CPNE5 Gene at MOPED

Post-translational modifications for CPNE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPNE5 Gene

No data available for DME Specific Peptides for CPNE5 Gene

Domains & Families for CPNE5 Gene

Gene Families for CPNE5 Gene

Protein Domains for CPNE5 Gene

Suggested Antigen Peptide Sequences for CPNE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE5: view

Function for CPNE5 Gene

Molecular function for CPNE5 Gene

GENATLAS Biochemistry:
copine 5,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in several tissues
UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology (GO) - Molecular Function for CPNE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CPNE5: view
genes like me logo Genes that share phenotypes with CPNE5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE5 Gene

Localization for CPNE5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE5 Gene

Perikaryon. Cell projection.

Subcellular locations from

Jensen Localization Image for CPNE5 Gene COMPARTMENTS Subcellular localization image for CPNE5 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CPNE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043204 perikaryon IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CPNE5: view

Pathways & Interactions for CPNE5 Gene

SuperPathways for CPNE5 Gene

No Data Available

Interacting Proteins for CPNE5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000244751 for CPNE5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CPNE5 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPNE5 Gene

Drugs & Compounds for CPNE5 Gene

(1) Drugs for CPNE5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CPNE5: view

Transcripts for CPNE5 Gene

Unigene Clusters for CPNE5 Gene

Copine V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - - - -
SP2: - -
SP3: -
SP4: - -
SP5: - -
SP7: - -

ExUns: 23a · 23b ^ 24 ^ 25
SP1: -
SP4: -

Relevant External Links for CPNE5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE5 Gene

mRNA expression in normal human tissues for CPNE5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPNE5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.3), Heart - Atrial Appendage (x5.8), Brain - Putamen (basal ganglia) (x4.6), and Brain - Caudate (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for CPNE5 Gene

This gene is overexpressed in Brain (28.7), Heart (25.6), and Frontal cortex (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPNE5 Gene

SOURCE GeneReport for Unigene cluster for CPNE5 Gene Hs.657869

mRNA Expression by UniProt/SwissProt for CPNE5 Gene

Tissue specificity: Expressed in the brain, heart, stomach, spleen, lymph node and testis (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with CPNE5: view

Protein tissue co-expression partners for CPNE5 Gene

Primer Products

Orthologs for CPNE5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE5 35
  • 92.41 (n)
  • 98.31 (a)
CPNE5 36
  • 98 (a)
(Canis familiaris)
Mammalia CPNE5 35
  • 92.3 (n)
  • 98.48 (a)
CPNE5 36
  • 98 (a)
(Mus musculus)
Mammalia Cpne5 35
  • 89.54 (n)
  • 97.98 (a)
Cpne5 16
Cpne5 36
  • 98 (a)
(Pan troglodytes)
Mammalia CPNE5 35
  • 99.55 (n)
  • 100 (a)
CPNE5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpne5 35
  • 89.38 (n)
  • 97.81 (a)
(Monodelphis domestica)
Mammalia CPNE5 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE5 36
  • 82 (a)
(Gallus gallus)
Aves CPNE5 36
  • 79 (a)
(Anolis carolinensis)
Reptilia CPNE5 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne9 35
  • 70.95 (n)
  • 84.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32366 35
(Danio rerio)
Actinopterygii cpne5 35
  • 78.03 (n)
  • 88.81 (a)
zgc64194 35
cpne5 36
  • 87 (a)
CPNE5 (1 of 2) 36
  • 82 (a)
(Caenorhabditis elegans)
Secernentea nra-1 35
  • 50.69 (n)
  • 48.49 (a)
cpna-4 36
  • 23 (a)
cpna-5 36
  • 24 (a)
gem-4 36
  • 41 (a)
nra-1 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for CPNE5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE5 Gene

Gene Tree for CPNE5 (if available)
Gene Tree for CPNE5 (if available)

Paralogs for CPNE5 Gene

Paralogs for CPNE5 Gene

(9) SIMAP similar genes for CPNE5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPNE5: view

Variants for CPNE5 Gene

Sequence variations from dbSNP and Humsavar for CPNE5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3734334 - 36,823,096(-) CAGGA(A/G)CCTCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs3830138 - 36,742,305(+) GCGTG(C/T)GGGCT downstream-variant-500B, reference, missense
rs1007956 -- 36,807,437(+) gaaga(C/G)agcct intron-variant
rs1007957 -- 36,807,635(+) TCCAC(A/C)CCTGA intron-variant
rs1010790 -- 36,748,056(-) GGCAG(A/T)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE5 Gene

Variant ID Type Subtype PubMed ID
nsv885809 CNV Loss 21882294
dgv6835n71 CNV Loss 21882294
nsv524053 CNV Loss 19592680
nsv819609 CNV Loss 19587683
dgv379n21 CNV Loss 19592680
nsv885813 CNV Loss 21882294
nsv885814 CNV Loss 21882294
nsv5261 CNV Loss 18451855
nsv818413 CNV Loss 17921354
esv991181 CNV Deletion 20482838
esv2731931 CNV Deletion 23290073
nsv5262 CNV Loss 18451855

Variation tolerance for CPNE5 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPNE5 Gene

Disorders for CPNE5 Gene

Relevant External Links for CPNE5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPNE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE5 Gene

Publications for CPNE5 Gene

  1. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo J.C. … Yoon T.J. (J. Dermatol. Sci. 2013) 3 4 67
  2. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3

Products for CPNE5 Gene

Sources for CPNE5 Gene