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Aliases for CPNE5 Gene

Aliases for CPNE5 Gene

  • Copine V 2 3 4
  • CPN5 3 6
  • Copine-5 3
  • KIAA1599 4
  • COPN5 3

External Ids for CPNE5 Gene

Previous GeneCards Identifiers for CPNE5 Gene

  • GC06M036710
  • GC06M036755
  • GC06M036426

Summaries for CPNE5 Gene

Entrez Gene Summary for CPNE5 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE5 Gene

CPNE5 (Copine V) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE5 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE5 Gene

Genomics for CPNE5 Gene

Regulatory Elements for CPNE5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPNE5 Gene

Start:
36,740,772 bp from pter
End:
36,840,002 bp from pter
Size:
99,231 bases
Orientation:
Minus strand

Genomic View for CPNE5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE5 Gene

Proteins for CPNE5 Gene

  • Protein details for CPNE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCH3-CPNE5_HUMAN
    Recommended name:
    Copine-5
    Protein Accession:
    Q9HCH3
    Secondary Accessions:
    • Q7Z6C8

    Protein attributes for CPNE5 Gene

    Size:
    593 amino acids
    Molecular mass:
    65734 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13425.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CPNE5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE5 Gene

Proteomics data for CPNE5 Gene at MOPED

Post-translational modifications for CPNE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPNE5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPNE5 Gene

Domains for CPNE5 Gene

Protein Domains for CPNE5 Gene

Suggested Antigen Peptide Sequences for CPNE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCH3

UniProtKB/Swiss-Prot:

CPNE5_HUMAN :
  • Q9HCH3
Domain:
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE5: view

No data available for Gene Families for CPNE5 Gene

Function for CPNE5 Gene

Molecular function for CPNE5 Gene

GENATLAS Biochemistry: copine 5,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in several tissues
UniProtKB/Swiss-Prot Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

Gene Ontology (GO) - Molecular Function for CPNE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CPNE5: view

Phenotypes for CPNE5 Gene

GenomeRNAi human phenotypes for CPNE5:
genes like me logo Genes that share phenotypes with CPNE5: view

Animal Model Products

CRISPR Products

miRNA for CPNE5 Gene

miRTarBase miRNAs that target CPNE5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPNE5 Gene

Localization for CPNE5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE5 Gene COMPARTMENTS Subcellular localization image for CPNE5 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CPNE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CPNE5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE5 Gene

Pathways for CPNE5 Gene

SuperPathways for CPNE5 Gene

No Data Available

Interacting Proteins for CPNE5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244751%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000244751 for CPNE5 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CPNE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:1903861 positive regulation of dendrite extension IDA 23999003
genes like me logo Genes that share ontologies with CPNE5: view

No data available for Pathways by source for CPNE5 Gene

Compounds for CPNE5 Gene

(1) HMDB Compounds for CPNE5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CPNE5: view

Transcripts for CPNE5 Gene

Unigene Clusters for CPNE5 Gene

Copine V:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CPNE5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - - - -
SP2: - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - -
SP8:

ExUns: 23a · 23b ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CPNE5 Gene

GeneLoc Exon Structure for
CPNE5
ECgene alternative splicing isoforms for
CPNE5

Expression for CPNE5 Gene

mRNA expression in normal human tissues for CPNE5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPNE5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.3), Heart - Atrial Appendage (5.8), Brain - Putamen (basal ganglia) (4.6), and Brain - Caudate (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPNE5 Gene

SOURCE GeneReport for Unigene cluster for CPNE5 Gene Hs.657869

genes like me logo Genes that share expressions with CPNE5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPNE5 Gene

Orthologs for CPNE5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE5 35
  • 99.55 (n)
  • 100 (a)
CPNE5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPNE5 35
  • 92.41 (n)
  • 98.31 (a)
CPNE5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE5 35
  • 92.3 (n)
  • 98.48 (a)
CPNE5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne5 35
  • 89.54 (n)
  • 97.98 (a)
Cpne5 16
Cpne5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPNE5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE5 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne5 35
  • 89.38 (n)
  • 97.81 (a)
chicken
(Gallus gallus)
Aves CPNE5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPNE5 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32366 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne9 35
  • 70.95 (n)
  • 84.86 (a)
zebrafish
(Danio rerio)
Actinopterygii cpne5 35
  • 78.03 (n)
  • 88.81 (a)
cpne5 36
  • 87 (a)
OneToMany
CPNE5 (1 of 2) 36
  • 82 (a)
OneToMany
zgc64194 35
worm
(Caenorhabditis elegans)
Secernentea cpna-4 36
  • 23 (a)
ManyToMany
cpna-5 36
  • 24 (a)
ManyToMany
gem-4 36
  • 41 (a)
ManyToMany
nra-1 35
  • 50.69 (n)
  • 48.49 (a)
nra-1 36
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CPNE5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE5 Gene

ENSEMBL:
Gene Tree for CPNE5 (if available)
TreeFam:
Gene Tree for CPNE5 (if available)

Paralogs for CPNE5 Gene

Paralogs for CPNE5 Gene

Selected SIMAP similar genes for CPNE5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPNE5: view

Variants for CPNE5 Gene

Sequence variations from dbSNP and Humsavar for CPNE5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3259 -- 36,740,834(+) GTCTC(A/G)GAGAC utr-variant-3-prime
rs86707 -- 36,767,688(-) CACCA(C/T)GACTG intron-variant
rs110033 -- 36,807,466(+) TGTAC(A/G)TAAGT intron-variant
rs171032 -- 36,777,209(-) TCACT(C/T)GGCCG intron-variant
rs171033 -- 36,763,439(-) TTTTA(A/G)TAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE5 Gene

Variant ID Type Subtype PubMed ID
nsv885809 CNV Loss 21882294
dgv6835n71 CNV Loss 21882294
nsv524053 CNV Loss 19592680
nsv819609 CNV Loss 19587683
dgv379n21 CNV Loss 19592680
nsv885813 CNV Loss 21882294
nsv885814 CNV Loss 21882294
nsv5261 CNV Loss 18451855
nsv818413 CNV Loss 17921354
esv991181 CNV Deletion 20482838
esv2731931 CNV Deletion 23290073
nsv5262 CNV Loss 18451855

Relevant External Links for CPNE5 Gene

HapMap Linkage Disequilibrium report
CPNE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE5 Gene

Disorders for CPNE5 Gene

Relevant External Links for CPNE5

Genetic Association Database (GAD)
CPNE5
Human Genome Epidemiology (HuGE) Navigator
CPNE5
genes like me logo Genes that share disorders with CPNE5: view

No data available for UniProtKB/Swiss-Prot for CPNE5 Gene

Publications for CPNE5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for CPNE5 Gene

Sources for CPNE5 Gene

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