CPNE4 Gene
protein-coding GIFtS : 50
GCID: GC03 M131253
copine IV
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Aliasesfor CPNE4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Copine IV 1 2 3 Copine-41 COPN41 2 Copine-83 CPN41 2 Copine-83 Copine 82
Export aliases for CPNE4 gene to outside databases Previous GC identifers: GC03M128164 GC03M131993 GC03M132534 GC03M132574 GC03M132573 GC03M132736 GC03M128638
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Summariesfor CPNE4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CPNE4 : Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23 Function : May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity) Gene Wiki entry for CPNE4
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Genomic Viewsfor CPNE4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_005612.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPNE4 gene promoter: GR GR-beta Nkx2-5 AP-2gamma CREB deltaCREB AP-2beta GR-alpha AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for CPNE4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q22.1 CPNE4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M131253: view genomic region
(about GC identifiers )
Start:
131,252,399 bp from pter
End:
132,004,254 bp from pter
Size:
751,856 bases
Orientation:
minus strand
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Proteinsfor CPNE4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23 (See
protein sequence )Recommended Name: Copine-4 Size : 557 amino acids; 62395 Da
Subunit : Interacts with CCDC22 (By similarity)
Secondary accessions : D3DNC5 Q8TEX1Alternative splicing : 2 isoforms : Q96A23-1 Q96A23-2 Explore the universe of human proteins at neXtProt for CPNE4: NX_Q96A23 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96A23 CPNE4 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_570720.1 ENSEMBL proteins: ENSP00000421705 ENSP00000424853 ENSP00000423811 ENSP00000421646 ENSP00000425506 ENSP00000427561 ENSP00000421394 ENSP00000411904 Human Recombinant Protein Products for CPNE4: CPNE4 Antibody Products: Assay Products for CPNE4:
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Protein
Domains / Familiesfor CPNE4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CPNE4 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96A23 ProtoNet protein and cluster: Q96A23
2 Blocks protein families : IPB000008 C2 domain IPB010734 Copine UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23 Similarity : Belongs to the copine familySimilarity : Contains 2 C2 domainsSimilarity : Contains 1 VWFA domain
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Functionfor CPNE4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: CPNE4_HUMAN, Q96A23 Function : May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
CPNE4 for ontologies About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for CPNE4 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPNE4 (NM_130808 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE4
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Pathways & Interactionsfor CPNE4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE4 5/16 Interacting proteins for CPNE4 (Q96A23 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 16 )About this table
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Drugs & Compoundsfor CPNE4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CPNE4 1 HMDB Compound for CPNE4 About this table Search CenterWatch for drugs/clinical trials and news about CPNE4
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Transcriptsfor CPNE4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CPNE4 gene: NM_130808.1 Unigene Cluster for CPNE4:
Copine IV Hs.199877 [show with all ESTs ] Unigene Representative Sequence: AK128117 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000514439 (uc003eoj.3 ) ENST00000512055 (uc003eok.3 uc011blq.2 uc003eol.3 uc003eom.3 )ENST00000515418 ENST00000503204 ENST00000512332 ENST00000511604 ENST00000502818 ENST00000505881 ENST00000514999 ENST00000505957 ENST00000506687 ENST00000505331 ENST00000429747 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPNE4 (NM_130808 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE4
Additional cDNA sequence: AF465770.1 AF465771.1 AK056175.1 AK128117.1 AK295557.1 BC014396.1 BC028613.1 BC075046.2
8 DOTS entries : DT.444518 DT.412971
DT.100754574 DT.444351 DT.91810645 DT.75194296 DT.97762725 DT.120908908 24/105 AceView cDNA sequences (see all 105 ):
F03476 BC075046 CR617237 F02842 H14519 Z38889 AL536384 F03803 Z38256 CB055198 AA431658 AA431302 CF552527 AK056175 Z44832 AF465771 F01714 CR593567 F10731 AI094803 BE645967 BM927288 Z42181 BC014396 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE4 About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 SP1 :                               -       SP2 :                                     SP3 :   -                                  
ECgene alternative splicing isoforms for CPNE4
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Expression for CPNE4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CPNE4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GACTGTATTTAbout this image CPNE4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Genevestigator expression for CPNE4 SOURCE GeneReport for Unigene cluster: Hs.199877 SABiosciences Custom PCR Arrays for CPNE4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPNE4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CPNE4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPNE4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPNE4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE4
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Orthologsfor CPNE4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPNE4 gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for CPNE4 (if available)TreeFam Gene Tree for CPNE4 (if available)
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Paralogsfor CPNE4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CPNE4 gene CPNE9 2 CPNE2 2 CPNE6 2 CPNE3 2 CPNE5 2 CPNE8 2 CPNE7 2 CPNE1 2 9 SIMAP similar genes for CPNE4 using alignment to 5 protein entries: CPNE4_HUMAN (see all proteins ):DKFZp666C234 CPNE7 CPNE5 CPNE8 CPNE2 CPNE6 CPNE1 CPNE3 CPNE9
CPNE4 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for CPNE4 PGOHUM00000237776
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Genomic Variantsfor CPNE4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CPNE4 (131252399 - 131502399 bp, first 250kb of CPNE4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 27 variations for CPNE4 15/20 CNVs (see all 20 ): 98452 98451 50928 4354 59089 68466 98449 63591 4353 62103 32517 50931 50930 68465 36065 7 Indels : 46294 62101 46291 68464 62102 46293 46292
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPNE4
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Disorders
/ Diseasesfor CPNE4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CPNE4 for disorders About GeneDecksing
OMIM gene information: 604208
OMIM disorders : --2 diseases for CPNE4 : About MalaCards hermaphroditism infertility Human Genome Epidemiology (HuGE) Navigator: CPNE4 (1 document)Export disorders for CPNE4 gene to outside databases
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Publicationsfor CPNE4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CPNE4 gene integrated from 9 sources : (articles sorted by number of sources associating them with CPNE4) Utopia : connect your pdf to the dynamic world of online information
Cloning, molecular characterization, and expression analysis of copine 8. (PubMed id 12670487) 1 , 2 , 3 Maitra R.... Lee B. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674) 1 , 3 Creutz C.E.... Cohen J. (1998) Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922) 1 Ramsuran V....Ndung'u T. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. (PubMed id 12522145) 1 Tomsig J.L....Creutz C.E. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CPNE4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CPNE4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CPNE4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CPNE4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CPNE4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CPNE4 gene: Search GeneIP for patents involving CPNE4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CPNE4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CPNE4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPNE4 OriGene Protein Over-expression Lysate for CPNE4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CPNE4 OriGene 3'-UTR Clone for CPNE4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CPNE4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CPNE4 OriGene Custom Protein Services for CPNE4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPNE4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPNE4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CPNE4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPNE4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPNE4
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CPNE4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE4
Search ThermoFisher Antibodies for CPNE4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE4
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Aliases for CPNE4
Databases for CPNE4
Disorders / Diseases for CPNE4
Domains / Families for CPNE4
Drugs / Compounds for CPNE4
Expression for CPNE4
Function for CPNE4
Genomic Views for CPNE4
Intellectual Property for CPNE4
Orthologs for CPNE4
Paralogs for CPNE4
Pathways / Interactions for CPNE4
Products for CPNE4
Proteins for CPNE4
Publications for CPNE4
Search Box for CPNE4
Summaries for CPNE4
Transcripts for CPNE4
Variants for CPNE4
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