Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPNE4 Gene

Aliases for CPNE4 Gene

  • Copine IV 2 3 4
  • Copine 8 2 3
  • Copine-8 4
  • COPN4 3
  • CPN4 3

External Ids for CPNE4 Gene

Previous GeneCards Identifiers for CPNE4 Gene

  • GC03M128164
  • GC03M131993
  • GC03M132534
  • GC03M132574
  • GC03M132573
  • GC03M132736
  • GC03M131253
  • GC03M128638

Summaries for CPNE4 Gene

Entrez Gene Summary for CPNE4 Gene

  • This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CPNE4 Gene

CPNE4 (Copine IV) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE4 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Wiki entry for CPNE4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE4 Gene

Genomics for CPNE4 Gene

Regulatory Elements for CPNE4 Gene

Genomic Location for CPNE4 Gene

131,533,555 bp from pter
132,285,547 bp from pter
751,993 bases
Minus strand

Genomic View for CPNE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE4 Gene

Proteins for CPNE4 Gene

  • Protein details for CPNE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNC5
    • Q8TEX1

    Protein attributes for CPNE4 Gene

    557 amino acids
    Molecular mass:
    62395 Da
    Quaternary structure:
    • Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP (PubMed:12522145).

    Alternative splice isoforms for CPNE4 Gene


neXtProt entry for CPNE4 Gene

Proteomics data for CPNE4 Gene at MOPED

Post-translational modifications for CPNE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CPNE4 Gene

Domains & Families for CPNE4 Gene

Gene Families for CPNE4 Gene

Protein Domains for CPNE4 Gene


Suggested Antigen Peptide Sequences for CPNE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE4: view

Function for CPNE4 Gene

Molecular function for CPNE4 Gene

UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Ontology (GO) - Molecular Function for CPNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12522145
genes like me logo Genes that share ontologies with CPNE4: view
genes like me logo Genes that share phenotypes with CPNE4: view

Animal Model Products

miRNA for CPNE4 Gene

miRTarBase miRNAs that target CPNE4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE4 Gene

Localization for CPNE4 Gene

Subcellular locations from

Jensen Localization Image for CPNE4 Gene COMPARTMENTS Subcellular localization image for CPNE4 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CPNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE4 Gene

Pathways & Interactions for CPNE4 Gene

SuperPathways for CPNE4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPNE4 Gene

Drugs & Compounds for CPNE4 Gene

(1) Drugs for CPNE4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CPNE4: view

Transcripts for CPNE4 Gene

Unigene Clusters for CPNE4 Gene

Copine IV:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: -
SP3: -

Relevant External Links for CPNE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE4 Gene

mRNA expression in normal human tissues for CPNE4 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE4 Gene

This gene is overexpressed in Prostate (x7.6), Brain - Frontal Cortex (BA9) (x6.1), Brain - Hippocampus (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.9), Brain - Cortex (x5.1), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for CPNE4 Gene

This gene is overexpressed in Fetal Brain (20.6), Brain (20.5), Frontal cortex (11.5), and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE4 Gene

SOURCE GeneReport for Unigene cluster for CPNE4 Gene Hs.199877

mRNA Expression by UniProt/SwissProt for CPNE4 Gene

Tissue specificity: Widely expressed (PubMed:12670487, PubMed:12949241). Expressed strongly in the brain, heart and prostate (PubMed:12670487, PubMed:12949241). Expressed strongly in peripheral blood leukocytes (PubMed:12949241).
genes like me logo Genes that share expression patterns with CPNE4: view

Protein tissue co-expression partners for CPNE4 Gene

Primer Products

In Situ Assay Products

Orthologs for CPNE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CPNE4 35
  • 94.09 (n)
  • 99.3 (a)
CPNE4 36
  • 97 (a)
(Mus musculus)
Mammalia Cpne4 35
  • 91.26 (n)
  • 99.46 (a)
Cpne4 16
Cpne4 36
  • 99 (a)
(Pan troglodytes)
Mammalia CPNE4 35
  • 99.88 (n)
  • 100 (a)
CPNE4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpne4 35
  • 90.37 (n)
  • 99.46 (a)
(Bos Taurus)
Mammalia CPNE4 36
  • 100 (a)
(Monodelphis domestica)
Mammalia CPNE4 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE4 36
  • 97 (a)
(Gallus gallus)
Aves CPNE4 35
  • 86.37 (n)
  • 97.32 (a)
CPNE4 36
  • 95 (a)
(Anolis carolinensis)
Reptilia CPNE4 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne4 35
  • 81.01 (n)
  • 93.85 (a)
(Danio rerio)
Actinopterygii cpne4 35
  • 78.54 (n)
  • 88.79 (a)
cpne4 36
  • 89 (a)
CPNE4 (1 of 2) 36
  • 87 (a)
(Caenorhabditis elegans)
Secernentea cpna-4 36
  • 20 (a)
cpna-5 36
  • 21 (a)
gem-4 36
  • 35 (a)
nra-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for CPNE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE4 Gene

Gene Tree for CPNE4 (if available)
Gene Tree for CPNE4 (if available)

Paralogs for CPNE4 Gene

Paralogs for CPNE4 Gene

(9) SIMAP similar genes for CPNE4 Gene using alignment to 5 proteins: Pseudogenes for CPNE4 Gene

genes like me logo Genes that share paralogs with CPNE4: view

Variants for CPNE4 Gene

Sequence variations from dbSNP and Humsavar for CPNE4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs440231 -- 132,102,184(+) accaa(C/T)caaaa intron-variant
rs471878 -- 132,102,398(+) tgaac(A/G)tcaac intron-variant
rs733344 -- 131,908,964(-) CAATA(A/C)CAATA intron-variant
rs747501 -- 131,910,458(-) AGTGC(A/G)TCTGA intron-variant
rs747502 -- 131,910,267(-) GAGTT(C/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE4 Gene

Variant ID Type Subtype PubMed ID
nsv829724 CNV Gain 17160897
nsv819184 CNV Loss 19587683
esv275136 CNV Loss 21479260
esv2725922 CNV Deletion 23290073
esv2672134 CNV Deletion 23128226
esv2557143 CNV Deletion 19546169
esv2322581 CNV Deletion 18987734
esv2725923 CNV Deletion 23290073
dgv1509e1 CNV Complex 17122850
esv2725924 CNV Deletion 23290073
esv2514810 CNV Deletion 19546169
esv2040947 CNV Deletion 18987734
esv5730 CNV Loss 19470904
esv2725925 CNV Deletion 23290073
esv2658353 CNV Deletion 23128226
nsv829725 CNV Gain 17160897
esv2677391 CNV Deletion 23128226
nsv516494 CNV Loss 19592680
esv2725926 CNV Deletion 23290073
esv2725927 CNV Deletion 23290073
nsv4007 CNV Loss 18451855
esv1088025 CNV Insertion 17803354
esv2725928 CNV Deletion 23290073
nsv822255 CNV Loss 20364138
esv2574380 CNV Deletion 19546169
esv1987535 CNV Deletion 18987734
nsv527967 CNV Loss 19592680
esv271993 CNV Insertion 20981092
esv2661746 CNV Deletion 23128226
nsv4008 CNV Insertion 18451855
esv22316 CNV Gain 19812545
nsv829727 CNV Gain+Loss 17160897
esv22482 CNV Gain 19812545
esv2637398 CNV Deletion 19546169
esv2039184 CNV Deletion 18987734
esv2725930 CNV Deletion 23290073
esv8024 CNV Loss 19470904
nsv508955 CNV Insertion 20534489
nsv508244 CNV Loss 20534489
nsv511224 CNV Loss 21212237
nsv512813 CNV Insertion 21212237
esv1724962 CNV Insertion 17803354
nsv4009 CNV Loss 18451855
nsv513073 CNV Loss 21212237
nsv10325 CNV Loss 18304495
esv2421563 CNV Deletion 20811451
dgv825n67 CNV Loss 20364138
esv7928 CNV Loss 19470904
esv2725931 CNV Deletion 23290073
nsv499013 CNV Loss 21111241
dgv886e199 CNV Deletion 23128226
esv22865 CNV Loss 19812545
nsv514166 CNV Loss 21397061
nsv437883 CNV Loss 16468122
nsv433376 CNV Loss 18776910
nsv517016 CNV Loss 19592680

Variation tolerance for CPNE4 Gene

Residual Variation Intolerance Score: 6.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE4 Gene

Disorders for CPNE4 Gene

Relevant External Links for CPNE4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPNE4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE4 Gene

Publications for CPNE4 Gene

  1. Cloning, molecular characterization, and expression analysis of copine 8. (PMID: 12670487) Maitra R. … Lee B. (Biochem. Biophys. Res. Commun. 2003) 2 67
  2. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 67
  3. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PMID: 22959728) . … Zheng J.G. (Neurobiol. Aging 2013) 67
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  5. Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease. (PMID: 23202439) Szigeti K. … Ma C. (J. Alzheimers Dis. 2013) 67

Products for CPNE4 Gene

Sources for CPNE4 Gene

Back to Top