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CPNE4 Gene

protein-coding   GIFtS: 52
GCID: GC03M131253

Copine IV

  Search for CPNE4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine IV1 2 3
Copine 81 2
CPN42 5
COPN42
copine-42
Copine-83

External Ids:    HGNC: 23171   Entrez Gene: 1310342   Ensembl: ENSG000001963537   OMIM: 6042085   UniProtKB: Q96A233   

Export aliases for CPNE4 gene to outside databases

Previous GC identifers: GC03M128164 GC03M131993 GC03M132534 GC03M132574 GC03M132573 GC03M132736 GC03M128638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE4 Gene:
This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding
protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for CPNE4 Gene:
CPNE4 (copine IV) is a protein-coding gene. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)

Gene Wiki entry for CPNE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE4 gene promoter:
         GR   GR-beta   Nkx2-5   AP-2gamma   CREB   deltaCREB   AP-2beta   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE4 promoter sequence
   Search Chromatin IP Primers for CPNE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

CPNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M131253:  view genomic region     (about GC identifiers)

Start:
131,252,399 bp from pter      End:
132,004,254 bp from pter
Size:
751,856 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23 (See protein sequence)
Recommended Name: Copine-4  
Size: 557 amino acids; 62395 Da
Subunit: Interacts with CCDC22 (By similarity)
Secondary accessions: D3DNC5 Q8TEX1
Alternative splicing: 2 isoforms:  Q96A23-1   Q96A23-2   

Explore the universe of human proteins at neXtProt for CPNE4: NX_Q96A23

Explore proteomics data for CPNE4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPNE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276041.1  NP_570720.1  NP_702907.1  

    ENSEMBL proteins: 
     ENSP00000421705   ENSP00000424853   ENSP00000423811   ENSP00000421646   ENSP00000425506  
     ENSP00000427561   ENSP00000421394   ENSP00000411904  

    CPNE4 Human Recombinant Protein Products:

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    Novus Biologicals CPNE4 Proteins
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    Cloud-Clone Corp. Proteins for CPNE4

     
    Search eBioscience for Proteins for CPNE4 

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    Cloud-Clone Corp. ELISAs for CPNE4
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    Search eBioscience for ELISAs for CPNE4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q96A23

    ProtoNet protein and cluster: Q96A23

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with CPNE4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE4_HUMAN, Q96A23
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CPNE4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CPNE4:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPNE4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE4

    miRNA
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    miRTarBase miRNAs that target CPNE4:
    hsa-mir-335-5p (MIRT018790), hsa-mir-122-5p (MIRT023352), hsa-mir-148b-3p (MIRT019434)

    Block miRNA regulation of human, mouse, rat CPNE4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE4 (see all 17):
    hsa-miR-607 hsa-miR-495 hsa-miR-1273 hsa-miR-421 hsa-miR-649 hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCPNE4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CPNE4
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CPNE4 (NM_130808)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE4
    Interactions:

        Search GeneGlobe Interaction Network for CPNE4

    Selected Interacting proteins for CPNE4 (Q96A233) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093I2D: score=1 
    BCORQ6W2J93I2D: score=1 
    BICD1Q96G013I2D: score=1 
    CCDC22O608263I2D: score=1 
    CEP162Q5TB803I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE4

    1 HMDB Compound for CPNE4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPNE4 gene (3 alternative transcripts): 
    NM_001289112.1  NM_130808.2  NM_153429.1  

    Unigene Cluster for CPNE4:

    Copine IV
    Hs.199877  [show with all ESTs]
    Unigene Representative Sequence: AK128117
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514439(uc003eoj.3) ENST00000512055(uc003eok.3 uc011blq.2 uc003eol.3 uc003eom.3)
    ENST00000515418 ENST00000503204 ENST00000512332 ENST00000511604 ENST00000502818
    ENST00000505881 ENST00000514999 ENST00000505957 ENST00000506687 ENST00000505331
    ENST00000429747
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE4 (see all 17):
    hsa-miR-607 hsa-miR-495 hsa-miR-1273 hsa-miR-421 hsa-miR-649 hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCPNE4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CPNE4
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE4
    Clone
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    OriGene clones in human, mouse for CPNE4 (see all 7)
    OriGene ORF clones in mouse, rat for CPNE4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE4 (NM_130808)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE4
    Primer
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    OriGene qPCR primer pairs and template standards for CPNE4
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE4
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE4
      QuantiFast Probe-based Assays in human, mouse, rat CPNE4

    Additional mRNA sequence: 

    AF465770.1 AF465771.1 AK056175.1 AK128117.1 AK295557.1 BC014396.1 BC028613.1 BC075046.2 

    8 DOTS entries:

    DT.444518  DT.412971  DT.91810645  DT.100754574  DT.444351  DT.75194296  DT.97762725  DT.120908908 

    Selected AceView cDNA sequences (see all 105):

    NM_130808 F01774 CF552527 BM930746 Z42181 BE645967 BC014396 BM927288 
    AI094803 F10731 CR593567 AF465771 AK056175 F01714 Z44832 AA431302 
    F03476 BC075046 F02842 CR617237 Z38889 F03803 AL536384 H14519 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                            -               
    SP2:                                                                                                            
    SP3:        -                                                                                                   


    ECgene alternative splicing isoforms for CPNE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGTATTT
    CPNE4 Expression
    About this image


    CPNE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Epithalamus
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Telencephalon
             Floor plate-like cells
             brain/midbrain/lateral wall   
     
     Prostate (Endocrine System)
    CPNE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199877
        Custom PCR Arrays for CPNE4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPNE4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne41 , 5 copine IV1, 5 91.26(n)1
    99.46(a)1
      9 (56.61 cM)5
    740201  NM_028719.11  NP_082995.11 
     1045472865 
    chicken
    (Gallus gallus)
    Aves CPNE41 copine IV 86.37(n)
    97.32(a)
      420687  XM_004939448.1  XP_004939505.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE46
    copine IV
    96(a)
    1 ↔ 1
    6(37520578-37801260)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cpne41 copine IV 81.01(n)
    93.85(a)
      100488007  XM_002937744.2  XP_002937790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpne41 copine IV 78.54(n)
    88.79(a)
      100034637  XM_003200571.2  XP_003200619.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gem-46
    nra-16
    (see all 4)
    Protein GEM-4 (gem-4) mRNA, complete cds
    Protein NRA-1, isoform a (nra-1) mRNA, complete cd...
    (see all 4)
    35(a)
    34(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    IV(11745640-11748685) WBGene00001577
    IV(17281455-17284199) WBGene00012128


    ENSEMBL Gene Tree for CPNE4 (if available)
    TreeFam Gene Tree for CPNE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE4 gene
    CPNE92  CPNE22  CPNE62  CPNE32  CPNE52  CPNE82  CPNE72  CPNE12  
    9 SIMAP similar genes for CPNE4 using alignment to 5 protein entries:     CPNE4_HUMAN (see all proteins):
    DKFZp666C234    CPNE7    CPNE5    CPNE8    CPNE2    CPNE6
    CPNE1    CPNE3    CPNE9

    Find genes that share paralogs with CPNE4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CPNE4
    PGOHUM00000237776


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE4 (see all 11099)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074637241,2
    Cuntested1131742493(+) CGCCCA/G/TGCTAA 1 -- int10--------
    rs576873421,2
    C--128775138(+) TACAC-/ATGTGTG 1 -- int10--------
    rs1912732361,2
    --131253260(+) GACACC/TCTAAA 1 -- int10--------
    rs1165464441,2
    F--131253290(+) TTGGTA/GTAGTC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1850502521,2
    --131253366(+) CTATGC/TATCAC 1 -- int10--------
    rs1498767191,2
    C--131253620(+) ATTTT-/AAAAAGT 1 -- ut310--------
    rs1895653151,2
    --131253686(+) AATGTC/TTCAAA 1 -- ut310--------
    rs58526291,2
    C--131253882(+) AAAAAA/-TTGTC 1 -- ut311Minor allele frequency- -:0.00CSA 2
    rs1424246751,2
    F--131254043(+) TTCATG/AGTGCT 2 /P /L mis11Minor allele frequency- A:0.00NA 4550
    rs1428271641,2
    C--131254045(+) CATGGC/TGCTAG 2 A syn10--------

    HapMap Linkage Disequilibrium report for CPNE4 (131252399 - 131502399 bp, first 250kb of CPNE4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CPNE4 (see all 56):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677391CNV Deletion23128226
    esv2040947CNV Deletion18987734
    esv2725930CNV Deletion23290073
    esv2039184CNV Deletion18987734
    dgv886e199CNV Deletion23128226
    esv2557143CNV Deletion19546169
    esv2661746CNV Deletion23128226
    esv2725923CNV Deletion23290073
    esv2574380CNV Deletion19546169
    esv2725922CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE4
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604208    OMIM disorders: --


    Find genes that share disorders with CPNE4           About GenesLikeMe

    Genetic Association Database (GAD): CPNE4
    Human Genome Epidemiology (HuGE) Navigator: CPNE4 (1 document)

    Export disorders for CPNE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CPNE4)
        Utopia: connect your pdf to the dynamic
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    1. Cloning, molecular characterization, and expression analysis of copine 8. (PubMed id 12670487)1, 2, 3 Maitra R.... Lee B. (Biochem. Biophys. Res. Commun. 2003)
    2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (Clin. Infect. Dis. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (J. Biol. Chem. 1998)
    7. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (Neurobiol. Aging 2013)
    8. Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease. (PubMed id 23202439)1 Szigeti K....Ma C. (J. Alzheimers Dis. 2013)
    9. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131034 HGNC: 2317 AceView: CPNE4 Ensembl:ENSG00000196353 euGenes: HUgn131034
    ECgene: CPNE4 H-InvDB: CPNE4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE4 gene:
    Search GeneIP for patents involving CPNE4

    GeneCards and IP:
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