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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPNE4 Gene

protein-coding   GIFtS: 52
GCID: GC03M131253

Copine IV

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Copine IV1 2 3     copine-42
Copine 81 2     copine-82
COPN42     Copine-83
CPN42     

External Ids:    HGNC: 23171   Entrez Gene: 1310342   Ensembl: ENSG000001963537   OMIM: 6042085   UniProtKB: Q96A233   

Export aliases for CPNE4 gene to outside databases

Previous GC identifers: GC03M128164 GC03M131993 GC03M132534 GC03M132574 GC03M132573 GC03M132736 GC03M128638


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPNE4 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two
N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. (provided by RefSeq, Jul
2008)

GeneCards Summary for CPNE4 Gene: 
CPNE4 (copine IV) is a protein-coding gene. Diseases associated with CPNE4 include infertility. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)

Gene Wiki entry for CPNE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPNE4 gene promoter:
         GR   GR-beta   Nkx2-5   AP-2gamma   CREB   deltaCREB   AP-2beta   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPNE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

CPNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M131253:  view genomic region     (about GC identifiers)

Start:
131,252,399 bp from pter      End:
132,004,254 bp from pter
Size:
751,856 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23 (See protein sequence)
Recommended Name: Copine-4  
Size: 557 amino acids; 62395 Da
Subunit: Interacts with CCDC22 (By similarity)
Secondary accessions: D3DNC5 Q8TEX1
Alternative splicing: 2 isoforms:  Q96A23-1   Q96A23-2   

Explore the universe of human proteins at neXtProt for CPNE4: NX_Q96A23

Explore proteomics data for CPNE4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A23

  • CPNE4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPNE4 Protein Expression
    REFSEQ proteins: NP_570720.1  
    ENSEMBL proteins: 
     ENSP00000421705   ENSP00000424853   ENSP00000423811   ENSP00000421646   ENSP00000425506  
     ENSP00000427561   ENSP00000421394   ENSP00000411904  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018029 C2_membr_targeting
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR010734 Copine
     IPR000008 C2_Ca-dep
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q96A23

    ProtoNet protein and cluster: Q96A23

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE4_HUMAN, Q96A23
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE4_HUMAN, Q96A23
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CPNE4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CPNE4:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPNE4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPNE4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE4 
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    hsa-miR-607 hsa-miR-495 hsa-miR-1273 hsa-miR-421 hsa-miR-649 hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCPNE4 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE4

    5/16 Interacting proteins for CPNE4 (Q96A233) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093I2D: score=1 
    BCORQ6W2J93I2D: score=1 
    BICD1Q96G013I2D: score=1 
    CCDC22O608263I2D: score=1 
    CPNE1Q998293I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPNE4

    1 HMDB Compound for CPNE4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CPNE4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPNE4 gene: 
    NM_130808.1  

    Unigene Cluster for CPNE4:

    Copine IV
    Hs.199877  [show with all ESTs]
    Unigene Representative Sequence: AK128117
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514439(uc003eoj.3) ENST00000512055(uc003eok.3 uc011blq.2 uc003eol.3 uc003eom.3)
    ENST00000515418 ENST00000503204 ENST00000512332 ENST00000511604 ENST00000502818
    ENST00000505881 ENST00000514999 ENST00000505957 ENST00000506687 ENST00000505331
    ENST00000429747
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CPNE4 (see all 17):
    hsa-miR-607 hsa-miR-495 hsa-miR-1273 hsa-miR-421 hsa-miR-649 hsa-miR-3613-3p hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCPNE4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF465770.1 AF465771.1 AK056175.1 AK128117.1 AK295557.1 BC014396.1 BC028613.1 BC075046.2 

    8 DOTS entries:

    DT.444518  DT.412971  DT.91810645  DT.100754574  DT.444351  DT.75194296  DT.97762725  DT.120908908 

    24/105 AceView cDNA sequences (see all 105):

    NM_130808 F01774 CF552527 BM930746 Z42181 BE645967 BC014396 BM927288 
    AI094803 F10731 CR593567 AF465771 AK056175 F01714 Z44832 AA431302 
    F03476 BC075046 F02842 CR617237 Z38889 F03803 AL536384 H14519 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                            -               
    SP2:                                                                                                            
    SP3:        -                                                                                                   


    ECgene alternative splicing isoforms for CPNE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPNE4 expression in normal human tissues (normalized intensities)      CPNE4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGTATTT
    CPNE4 Expression
    About this image


    CPNE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Epithalamus
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Prostate (Endocrine System)

    See CPNE4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPNE4

    SOURCE GeneReport for Unigene cluster: Hs.199877
        SABiosciences Custom PCR Arrays for CPNE4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPNE4 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne41 , 5 copine IV1, 5 91.26(n)1
    99.46(a)1
      9 (56.61 cM)5
    740201  NM_028719.11  NP_082995.11 
     1045472865 
    chicken
    (Gallus gallus)
    Aves CPNE41 copine IV 86.57(n)
    97.66(a)
      420687  XM_418786.3  XP_418786.2 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE46
    copine IV
    96(a)
    1 ↔ 1
    6(37520578-37801260)
    zebrafish
    (Danio rerio)
    Actinopterygii cpne41 copine IV 78.54(n)
    88.79(a)
      100034637  XM_003200571.1  XP_003200619.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cpna-16
    cpna-26
    Copine family protein 2
    7(a)
    1(a)
    possible ortholog
    possible ortholog
    II(4186666-4208499)
    II(7724903-7752726)


    ENSEMBL Gene Tree for CPNE4 (if available)
    TreeFam Gene Tree for CPNE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPNE4 gene
    CPNE92  CPNE22  CPNE62  CPNE32  CPNE52  CPNE82  CPNE72  CPNE12  
    9 SIMAP similar genes for CPNE4 using alignment to 5 protein entries:     CPNE4_HUMAN (see all proteins):
    DKFZp666C234    CPNE7    CPNE5    CPNE8    CPNE2    CPNE6
    CPNE1    CPNE3    CPNE9

    CPNE4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CPNE4
    PGOHUM00000237776


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11099 SNPs in CPNE4 are shown (see all 11099)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074637241,2
    Cuntested1131742493(+) CGCCCA/G/TGCTAA 1 -- int10--------
    rs576873421,2
    C--128775138(+) TACAC-/ATGTGTG 1 -- int10--------
    rs1912732361,2
    --131253260(+) GACACC/TCTAAA 1 -- int10--------
    rs1165464441,2
    F--131253290(+) TTGGTA/GTAGTC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1850502521,2
    --131253366(+) CTATGC/TATCAC 1 -- int10--------
    rs1498767191,2
    C--131253620(+) ATTTT-/AAAAAGT 1 -- ut310--------
    rs1895653151,2
    --131253686(+) AATGTC/TTCAAA 1 -- ut310--------
    rs58526291,2
    C--131253882(+) AAAAAA/-TTGTC 1 -- ut311Minor allele frequency- -:0.00CSA 2
    rs1424246751,2
    F--131254043(+) TTCATG/AGTGCT 2 /P /L mis11Minor allele frequency- A:0.00NA 4550
    rs1428271641,2
    C--131254045(+) CATGGC/TGCTAG 2 A syn10--------

    HapMap Linkage Disequilibrium report for CPNE4 (131252399 - 131502399 bp, first 250kb of CPNE4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/56 variations for CPNE4 (see all 56):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677391CNV Deletion23128226
    esv2040947CNV Deletion18987734
    esv2725930CNV Deletion23290073
    esv2039184CNV Deletion18987734
    dgv886e199CNV Deletion23128226
    esv2557143CNV Deletion19546169
    esv2661746CNV Deletion23128226
    esv2725923CNV Deletion23290073
    esv2574380CNV Deletion19546169
    esv2725922CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604208    OMIM disorders: --

    2 diseases for CPNE4:    About MalaCards
    infertility    


    CPNE4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPNE4
    Human Genome Epidemiology (HuGE) Navigator: CPNE4 (1 document)

    Export disorders for CPNE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPNE4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CPNE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, molecular characterization, and expression analysis of copine 8. (PubMed id 12670487)1, 2, 3 Maitra R.... Lee B. (2003)
    2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (1998)
    7. Age of onset of amyotrophic lateral sclerosis is modul ated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (2013)
    8. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
    9. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131034 HGNC: 2317 AceView: CPNE4 Ensembl:ENSG00000196353 euGenes: HUgn131034
    ECgene: CPNE4 H-InvDB: CPNE4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPNE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPNE4 gene:
    Search GeneIP for patents involving CPNE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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