CPNE3 Gene
protein-coding GIFtS: 56
GCID: GC08P087497
|
|
copine III
| |
Aliases for CPNE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Copine III1 2 3 | | CPN32 3 5 | | PRO10712 | | Copine-31 | | KIAA06363 |
Export aliases for CPNE3 gene to outside databasesPrevious GC identifers: GC08P086047 GC08P087258 GC08P087483 GC08P087566 GC08P082736 |
Summaries for CPNE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CPNE3: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane andcytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an Adomain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellularligands. (provided by RefSeq, Aug 2008) UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity)
|
Genomic Views for CPNE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPNE3 gene promoter: HFH-3 HOXA3 AML1a FOXD1 Lmo2 GATA-1 FOXI1 IRF-2 HSF2 En-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for CPNE3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.3 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21CPNE3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P087497: view genomic region
(about GC identifiers)
Start:
|
87,497,059 bp from pter |
End:
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87,573,726 bp from pter |
Size:
|
76,668 bases |
Orientation:
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plus strand |
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Proteins for CPNE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131 (See
protein sequence)Recommended Name: Copine-3 Size: 537 amino acids; 60131 Da
Caution: Was reported (PubMed:11041869) to have a protein kinase activity
Sequence caution: Sequence=BAA31611.2; Type=Erroneous initiation;
Secondary accessions: A8KA47 Q8IYA1Explore the universe of human proteins at neXtProt for CPNE3: NX_O75131
Post-translational modifications:
Phosphorylated on serine and threonine residues1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75131 CPNE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003900.1 ENSEMBL proteins: ENSP00000430934 ENSP00000427791 ENSP00000428808 ENSP00000429420 ENSP00000429194 ENSP00000429561 ENSP00000427966 ENSP00000428561 ENSP00000198765 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CPNE3 for ontologies About GeneDecksing
CPNE3 Antibody Products: Assay Products for CPNE3: |
Protein
Domains / Families for CPNE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPNE3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75131ProtoNet protein and cluster: O75131 2 Blocks protein families: IPB000008 C2 domain IPB010734 Copine
UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131Similarity: Belongs to the copine familySimilarity: Contains 2 C2 domainsSimilarity: Contains 1 VWFA domain |
Function for CPNE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (Bysimilarity) Genatlas biochemistry entry for CPNE3:copine 3,calcium-dependent,phospholipid binding protein,potentially involved in regulating membranetrafficking,expressed in brain
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CPNE3 (NM_003909) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CPNE3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CPNE3:
|
Pathways & Interactions for CPNE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
 5/568 Interacting proteins for CPNE3 (O751312, 3 ENSP000001987654) via UniProtKB, MINT, STRING, and/or I2D (see all 568)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CPNE3 for ontologies About GeneDecksing
|
Drugs & Compounds for CPNE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CPNE3
1 HMDB Compound for CPNE3 About this table Search CenterWatch for drugs/clinical trials and news about CPNE3 
|
Transcripts for CPNE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CPNE3 gene: NM_003909.3 Unigene Cluster for CPNE3: Copine III Hs.191219 [show with all ESTs]Unigene Representative Sequence: NM_00390914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521271(uc003ydv.2) ENST00000523072 ENST00000523001 ENST00000520814 ENST00000523489 ENST00000517771 ENST00000523469 ENST00000522240 ENST00000517391 ENST00000517862 ENST00000517354 ENST00000517490(uc003ydw.1) ENST00000523588 ENST00000198765
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CPNE3 (NM_003909) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE3  |
Additional cDNA sequence: AB014536.1 AF077226.2 AF116654.1 AK025275.1 AK292912.1 BC007017.1 BC008385.1 BC015734.1 BC036242.1 BC066597.1 7 DOTS entries: DT.449453 DT.100677688 DT.100827051 DT.100827050 DT.121486717 DT.102829342 DT.92436892 24/321 AceView cDNA sequences (see all 321): BE670546 BU629296 BU689371 AW026680 AA866189 Z38754 W32758 AA923241 CA433525 CB153171 CA436101 BU619531 CB242400 BM564540 AI619979 BX480823 CA415581 BM786481 Z42575 BQ641778 BF515741 AA505111 AI609932 NM_003909 GeneLoc Exon Structure
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Expression for CPNE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPNE3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGTAAGTTAC
About this image See CPNE3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CPNE3
SOURCE GeneReport for Unigene cluster: Hs.191219 UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131Tissue specificity: Ubiquitous SABiosciences Custom PCR Arrays for CPNE3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPNE3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPNE3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPNE3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPNE3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE3 |
Orthologs for CPNE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPNE3 gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Cpne31 , 5 |
copine III1, 5 |
89.99(n)1 94.37(a)1 |
  |
4 (7.53 cM)5 705681 NM_027769.21 NP_082045.11 195192545 |
chicken (Gallus gallus) |
Aves |
CPNE31 |
copine III |
79.75(n) 85.98(a) |
  |
420214 XM_418324.3 XP_418324.2 |
lizard (Anolis carolinensis) |
Reptilia |
CPNE36 |
-- |
84(a) |
1 ↔ 1 |
4(22764523-22789465) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.31162 |
Transcribed sequence with moderate similarity to protein more |
76.34(n) |
  |
CF264329.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc556222 |
similar to copine III |
74.42(n) |
  |
393136 BC045408.1 |
worm (Caenorhabditis elegans) |
Secernentea |
T12A7.13 |
C2 domain (2 domains) |
43(a) (best of 2) |
  |
IV(11745848-11748760) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
BON31 |
protein BONZAI 3 |
50.13(n) 42.47(a) |
  |
837408 NM_100759.3 NP_172362.3 |
rice (Oryza sativa) |
Liliopsida |
Os05g03733001 |
hypothetical protein |
52.52(n) 47.92(a) |
  |
9266651 NM_001187464.1 NP_001174393.1 |
ENSEMBL Gene Tree for CPNE3 (if available) TreeFam Gene Tree for CPNE3 (if available)  |
Paralogs for CPNE3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CPNE3 gene
- CPNE92 CPNE22 CPNE62 CPNE52 CPNE82 CPNE42 CPNE72 CPNE12
8 SIMAP similar genes for CPNE3 using alignment to 8 protein entries: CPNE3_HUMAN (see all proteins):CPNE1 CPNE2 CPNE8 CPNE9 CPNE7 CPNE4 CPNE5 CPNE6
CPNE3 for paralogs About GeneDecksing
|
Genomic Variants for CPNE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for CPNE3 (87497059 - 87573726 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CPNE3 1 CNV: 5257  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPNE3 |
|
Disorders
/ Diseases for CPNE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPNE3 for disorders About GeneDecksing
OMIM gene information: 604207
OMIM disorders: --
4 diseases for CPNE3: About MalaCardshermaphroditism infertility prostate cancer prostatitis Human Genome Epidemiology (HuGE) Navigator: CPNE3 (2 documents) Export disorders for CPNE3 gene to outside databases
|
Publications for CPNE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPNE3 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with CPNE3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of human copine III as a phosphoprotein with associated kinase activity. (PubMed id 11041869)1, 2 Caudell E.G....Grimm E.A. (2000)
- The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (1998)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for CPNE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CPNE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPNE3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CPNE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for CPNE3 gene: Search GeneIP for patents involving CPNE3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CPNE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | OriGene Antibodies for CPNE3 | | OriGene shRNA RFP for CPNE3 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPNE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPNE3 | | OriGene Protein Over-expression Lysate for CPNE3 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for CPNE3 | | OriGene 3'-UTR Clone for CPNE3 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPNE3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for CPNE3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for CPNE3 | | OriGene Custom Protein Services for CPNE3 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | | Search Tocris compounds for CPNE3 |
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 | | CPNE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE3 |
|  |  |  | | | ThermoFisher Antibody for CPNE3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE3 |
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