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CPNE3 Gene

protein-coding   GIFtS: 61
GCID: GC08P087497

Copine III

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine III1 2 3
CPN32 3 5
PRO10712
copine-32
KIAA06363

External Ids:    HGNC: 23161   Entrez Gene: 88952   Ensembl: ENSG000000857197   OMIM: 6042075   UniProtKB: O751313   

Export aliases for CPNE3 gene to outside databases

Previous GC identifers: GC08P086047 GC08P087258 GC08P087483 GC08P087566 GC08P082736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE3 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A
domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and
extracellular ligands. (provided by RefSeq, Aug 2008)

GeneCards Summary for CPNE3 Gene:
CPNE3 (copine III) is a protein-coding gene. GO annotations related to this gene include calcium-dependent phospholipid binding and protein serine/threonine kinase activity. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE3 gene promoter:
         HFH-3   HOXA3   AML1a   FOXD1   Lmo2   GATA-1   FOXI1   IRF-2   HSF2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE3 promoter sequence
   Search Chromatin IP Primers for CPNE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21

CPNE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P087497:  view genomic region     (about GC identifiers)

Start:
87,497,059 bp from pter      End:
87,573,726 bp from pter
Size:
76,668 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131 (See protein sequence)
Recommended Name: Copine-3  
Size: 537 amino acids; 60131 Da
Caution: Was reported (PubMed:11041869) to have a protein kinase activity
Sequence caution: Sequence=BAA31611.2; Type=Erroneous initiation;
Secondary accessions: A8KA47 Q8IYA1

Explore the universe of human proteins at neXtProt for CPNE3: NX_O75131

Explore proteomics data for CPNE3 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues1
  • Ubiquitination2 at Lys158, Lys167, Lys184
  • Modification sites at PhosphoSitePlus

  • See CPNE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003900.1  
    ENSEMBL proteins: 
     ENSP00000430934   ENSP00000427791   ENSP00000428808   ENSP00000429420   ENSP00000429194  
     ENSP00000429561   ENSP00000427966   ENSP00000428561   ENSP00000198765  

    CPNE3 Human Recombinant Protein Products:

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    Novus Biologicals CPNE3 Proteins
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    Cloud-Clone Corp. Proteins for CPNE3

     
    Search eBioscience for Proteins for CPNE3 

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    Cloud-Clone Corp. ELISAs for CPNE3
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    Search eBioscience for ELISAs for CPNE3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry O75131

    ProtoNet protein and cluster: O75131

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with CPNE3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE3_HUMAN, O75131
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By
    similarity)

         Genatlas biochemistry entry for CPNE3:
    copine 3,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane
    trafficking,expressed in brain

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA11041869
    GO:0005215transporter activity TAS9430674
    GO:0005515protein binding ----
    GO:0005544calcium-dependent phospholipid binding TAS11041869
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CPNE3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPNE3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPNE3:
    hsa-mir-124-3p (MIRT002575), hsa-mir-133b (MIRT007128)

    Block miRNA regulation of human, mouse, rat CPNE3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE3 (see all 27):
    hsa-miR-16-2* hsa-miR-1271 hsa-miR-548s hsa-miR-3653 hsa-miR-570 hsa-miR-508-3p hsa-miR-124 hsa-miR-1323
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat CPNE3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CPNE3

    Clone
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    GenScript: all cDNA clones in your preferred vector: CPNE3 (NM_003909)
    Sino Biological Human cDNA Clone for CPNE3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS11041869
    GO:0005829cytosol IDA12949241
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CPNE3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE3
    Interactions:

        Search GeneGlobe Interaction Network for CPNE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CPNE3 (O751312, 3 ENSP000001987654) via UniProtKB, MINT, STRING, and/or I2D (see all 595)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    QARSP478973, ENSP000003075674I2D: score=4 STRING: ENSP00000307567
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11041869
    GO:0006629lipid metabolic process TAS9430674
    GO:0016192vesicle-mediated transport TAS9430674

    Find genes that share ontologies with CPNE3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE3

    1 HMDB Compound for CPNE3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPNE3 gene: 
    NM_003909.3  

    Unigene Cluster for CPNE3:

    Copine III
    Hs.191219  [show with all ESTs]
    Unigene Representative Sequence: NM_003909
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521271(uc003ydv.2) ENST00000523072 ENST00000523001 ENST00000520814
    ENST00000523489 ENST00000517771 ENST00000523469 ENST00000522240 ENST00000517391
    ENST00000517862 ENST00000517354 ENST00000517490(uc003ydw.1) ENST00000523588
    ENST00000198765
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE3 (see all 27):
    hsa-miR-16-2* hsa-miR-1271 hsa-miR-548s hsa-miR-3653 hsa-miR-570 hsa-miR-508-3p hsa-miR-124 hsa-miR-1323
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPNE3
    Clone
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    OriGene clones in human, mouse for CPNE3 (see all 7)
    OriGene ORF clones in mouse, rat for CPNE3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE3 (NM_003909)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE3
    Primer
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    OriGene qPCR primer pairs and template standards for CPNE3
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE3
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE3
      QuantiFast Probe-based Assays in human, mouse, rat CPNE3

    Additional mRNA sequence: 

    AB014536.1 AF077226.2 AF116654.1 AK025275.1 AK292912.1 BC007017.1 BC008385.1 BC015734.1 
    BC036242.1 BC066597.1 

    7 DOTS entries:

    DT.449453  DT.100677688  DT.100827051  DT.100827050  DT.121486717  DT.102829342  DT.92436892 

    Selected AceView cDNA sequences (see all 321):

    AA862806 AW026680 BG622373 AA282288 BM564540 CA436101 AI619979 BU689371 
    AI025809 AI031907 BU619531 Z42575 AI090365 AA923241 CR599032 BQ417467 
    BE670546 AI608788 AA866189 BF515741 CB242400 CA415581 BM786481 BX470270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAGTTAC
    CPNE3 Expression
    About this image


    CPNE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
     
     Esophagus (Gastrointestinal Tract)
    CPNE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191219

    UniProtKB/Swiss-Prot: CPNE3_HUMAN, O75131
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for CPNE3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPNE3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne31 , 5 copine III1, 5 89.99(n)1
    94.37(a)1
      4 (7.53 cM)5
    705681  NM_027769.21  NP_082045.11 
     195192545 
    chicken
    (Gallus gallus)
    Aves CPNE31 copine III 79.75(n)
    85.98(a)
      420214  XM_418324.4  XP_418324.2 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE36
    copine III
    85(a)
    1 ↔ 1
    4(22761999-22792447)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.31162 Transcribed sequence with moderate similarity to protein more 76.34(n)    CF264329.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556222 similar to copine III 74.42(n)   393136  BC045408.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BON21 BON2 50.43(n)
    44.77(a)
      830621  NM_120812.3  NP_568180.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05213001 Os02g0521300 49.42(n)
    42.02(a)
      4329499  NM_001053511.1  NP_001046976.1 


    ENSEMBL Gene Tree for CPNE3 (if available)
    TreeFam Gene Tree for CPNE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE3 gene
    CPNE92  CPNE22  CPNE62  CPNE52  CPNE82  CPNE42  CPNE72  CPNE12  
    8 SIMAP similar genes for CPNE3 using alignment to 8 protein entries:     CPNE3_HUMAN (see all proteins):
    CPNE1    CPNE2    CPNE8    CPNE9    CPNE7    CPNE4
    CPNE5    CPNE6

    Find genes that share paralogs with CPNE3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE3 (see all 1034)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004479101,2
    C--87524667(+) TCTTTG/TCCCCT 1 -- us2k10--------
    rs1481521481,2
    --87524806(+) TCCCTC/GTATCA 1 -- us2k10--------
    rs1849418461,2
    --87524893(+) ATTCAA/GCCGTC 1 -- us2k10--------
    rs61506871,2
    C--87524955(+) ATAGTAGGCAATC
    AGGATGT
    /-
    GTTTG
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs351547641,2
    C,F--87525008(+) AAAAAT/CGTTTA 1 -- us2k15Minor allele frequency- C:0.06NA WA 244
    rs1418865871,2
    --87525031(+) GGCACA/GGTGGC 1 -- us2k10--------
    rs1892706831,2
    --87525199(+) TTTTAA/CTTAAG 1 -- us2k10--------
    rs119864231,2
    C,F,H--87525268(+) TTCACC/TCATTT 1 -- us2k117Minor allele frequency- T:0.10NS EA NA WA CSA 1503
    rs2020623441,2
    C--87525304(+) TATCAA/GTTTAA 1 -- us2k10--------
    rs1817416501,2
    C--87525352(+) TAATCC/TCAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPNE3 (87497059 - 87573726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CPNE3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422239CNV Duplication17116639
    esv259871OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE3
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604207    OMIM disorders: --


    Find genes that share disorders with CPNE3           About GenesLikeMe

    Genetic Association Database (GAD): CPNE3
    Human Genome Epidemiology (HuGE) Navigator: CPNE3 (2 documents)

    Export disorders for CPNE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CPNE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Characterization of human copine III as a phosphoprotein with associated kinase activity. (PubMed id 11041869)1, 2 Caudell E.G....Grimm E.A. (Biochemistry 2000)
    4. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3 Creutz C.E.... Cohen J. (J. Biol. Chem. 1998)
    5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    6. Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC. (PubMed id 23713811)1 Lin H.C....Yao M. (J. Proteome Res. 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia. (PubMed id 23062752)1 Cohen O.S....Glatt S.J. (Schizophr. Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8895 HGNC: 2316 AceView: CPNE3 Ensembl:ENSG00000085719 euGenes: HUgn8895
    ECgene: CPNE3 H-InvDB: CPNE3

    (According to HUGE)
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    HUGE: KIAA0636

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPNE3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE3 gene:
    Search GeneIP for patents involving CPNE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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