Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPNE3 Gene

Aliases for CPNE3 Gene

  • Copine 3 2 3
  • Copine III 2 3 4 5
  • CPN3 3 4
  • KIAA0636 4
  • PRO1071 3

External Ids for CPNE3 Gene

Previous GeneCards Identifiers for CPNE3 Gene

  • GC08P086047
  • GC08P087258
  • GC08P087483
  • GC08P087566
  • GC08P087497
  • GC08P082736

Summaries for CPNE3 Gene

Entrez Gene Summary for CPNE3 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

GeneCards Summary for CPNE3 Gene

CPNE3 (Copine 3) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include poly(A) RNA binding and transporter activity. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE3 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE3 Gene

Genomics for CPNE3 Gene

Regulatory Elements for CPNE3 Gene

Enhancers for CPNE3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPNE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE3 Gene

86,484,830 bp from pter
86,561,498 bp from pter
76,669 bases
Plus strand

Genomic View for CPNE3 Gene

Genes around CPNE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE3 Gene

Proteins for CPNE3 Gene

  • Protein details for CPNE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8KA47
    • Q8IYA1

    Protein attributes for CPNE3 Gene

    537 amino acids
    Molecular mass:
    60131 Da
    Quaternary structure:
    • Monomer (PubMed:12949241). Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2 (PubMed:20010870). Interacts with RACK1 (PubMed:20010870).
    • Sequence=BAA31611.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CPNE3 Gene

Proteomics data for CPNE3 Gene at MOPED

Post-translational modifications for CPNE3 Gene

  • Phosphorylated on serine and threonine residues (PubMed:11041869).
  • Ubiquitination at Lys 158 and Lys 184
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CPNE3 Gene

Domains & Families for CPNE3 Gene

Gene Families for CPNE3 Gene

Protein Domains for CPNE3 Gene


Suggested Antigen Peptide Sequences for CPNE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE3: view

Function for CPNE3 Gene

Molecular function for CPNE3 Gene

GENATLAS Biochemistry:
copine 3,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in brain
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).

Gene Ontology (GO) - Molecular Function for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9430674
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0048306 calcium-dependent protein binding IDA 20010870
genes like me logo Genes that share ontologies with CPNE3: view
genes like me logo Genes that share phenotypes with CPNE3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPNE3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE3 Gene

Localization for CPNE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE3 Gene

Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870). {ECO:0000269 PubMed:20010870, ECO:0000269 PubMed:21087455}.

Subcellular locations from

Jensen Localization Image for CPNE3 Gene COMPARTMENTS Subcellular localization image for CPNE3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11041869
genes like me logo Genes that share ontologies with CPNE3: view

Pathways & Interactions for CPNE3 Gene

genes like me logo Genes that share pathways with CPNE3: view

Pathways by source for CPNE3 Gene

Gene Ontology (GO) - Biological Process for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11041869
GO:0006629 lipid metabolic process TAS 9430674
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with CPNE3: view

No data available for SIGNOR curated interactions for CPNE3 Gene

Drugs & Compounds for CPNE3 Gene

(1) Drugs for CPNE3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CPNE3: view

Transcripts for CPNE3 Gene

Unigene Clusters for CPNE3 Gene

Copine III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE3 Gene

No ASD Table

Relevant External Links for CPNE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE3 Gene

mRNA expression in normal human tissues for CPNE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE3 Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPNE3 Gene

SOURCE GeneReport for Unigene cluster for CPNE3 Gene Hs.191219

mRNA Expression by UniProt/SwissProt for CPNE3 Gene

Tissue specificity: Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).
genes like me logo Genes that share expression patterns with CPNE3: view

Protein tissue co-expression partners for CPNE3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CPNE3 Gene

Orthologs for CPNE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE3 35
  • 90.99 (n)
  • 95.31 (a)
CPNE3 36
  • 95 (a)
(Canis familiaris)
Mammalia CPNE3 35
  • 92.87 (n)
  • 96.25 (a)
CPNE3 36
  • 96 (a)
(Mus musculus)
Mammalia Cpne3 35
  • 89.99 (n)
  • 94.37 (a)
Cpne3 16
Cpne3 36
  • 94 (a)
(Pan troglodytes)
Mammalia CPNE3 35
  • 99.44 (n)
  • 99.26 (a)
CPNE3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cpne3 35
  • 88.62 (n)
  • 92.68 (a)
(Monodelphis domestica)
Mammalia CPNE3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE3 36
  • 89 (a)
(Gallus gallus)
Aves CPNE3 35
  • 79.75 (n)
  • 85.98 (a)
CPNE3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia CPNE3 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne3 35
  • 74.73 (n)
  • 81.43 (a)
Str.3116 35
(Danio rerio)
Actinopterygii cpne3 35
  • 69.19 (n)
  • 76.94 (a)
zgc55622 35
cpne3 36
  • 77 (a)
(Caenorhabditis elegans)
Secernentea T12A7.1 37
  • 43 (a)
Y73F8A.19 37
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BON2 35
  • 50.43 (n)
  • 44.77 (a)
(Oryza sativa)
Liliopsida Os02g0521300 35
  • 49.42 (n)
  • 42.02 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5235 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
-- 36
  • 55 (a)
CSA.7161 36
  • 53 (a)
Species with no ortholog for CPNE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE3 Gene

Gene Tree for CPNE3 (if available)
Gene Tree for CPNE3 (if available)

Paralogs for CPNE3 Gene

Paralogs for CPNE3 Gene

genes like me logo Genes that share paralogs with CPNE3: view

Variants for CPNE3 Gene

Sequence variations from dbSNP and Humsavar for CPNE3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2304789 - 86,554,965(-) GTTGC(A/G)TGGCT reference, missense
rs41333046 - 86,546,618(+) AATGA(C/G)AAAAA reference, missense
rs2119537 -- 86,545,910(+) TGTAG(A/G)AATTT intron-variant
rs2165462 -- 86,560,437(-) TGCTG(A/T)GGAGC utr-variant-3-prime
rs2304787 -- 86,556,416(-) ACCTA(A/C)TCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE3 Gene

Variant ID Type Subtype PubMed ID
esv259871 OTHER Complex 20981092
esv2422239 CNV Duplication 17116639

Variation tolerance for CPNE3 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.13; 92.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPNE3 Gene

Disorders for CPNE3 Gene

Relevant External Links for CPNE3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPNE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE3 Gene

Publications for CPNE3 Gene

  1. Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. (PMID: 21087455) Perestenko P.V. … Jeffrey McIlhinney R.A. (FEBS J. 2010) 3 4 67
  2. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CPNE3 Gene

Sources for CPNE3 Gene