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Aliases for CPNE3 Gene

Aliases for CPNE3 Gene

  • Copine III 2 3 4
  • CPN3 3 4 6
  • Copine-3 3
  • KIAA0636 4
  • PRO1071 3

External Ids for CPNE3 Gene

Previous GeneCards Identifiers for CPNE3 Gene

  • GC08P086047
  • GC08P087258
  • GC08P087483
  • GC08P087566
  • GC08P087497
  • GC08P082736

Summaries for CPNE3 Gene

Entrez Gene Summary for CPNE3 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

GeneCards Summary for CPNE3 Gene

CPNE3 (Copine III) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and calcium-dependent phospholipid binding. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE3 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE3 Gene

Genomics for CPNE3 Gene

Regulatory Elements for CPNE3 Gene

Genomic Location for CPNE3 Gene

86,484,830 bp from pter
86,561,498 bp from pter
76,669 bases
Plus strand

Genomic View for CPNE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE3 Gene

Proteins for CPNE3 Gene

  • Protein details for CPNE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8KA47
    • Q8IYA1

    Protein attributes for CPNE3 Gene

    537 amino acids
    Molecular mass:
    60131 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31611.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CPNE3 Gene

Proteomics data for CPNE3 Gene at MOPED

Post-translational modifications for CPNE3 Gene

  • Phosphorylated on serine and threonine residues.
  • Ubiquitination at Lys158, Lys167, and Lys184
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CPNE3 Gene

Domains for CPNE3 Gene

Protein Domains for CPNE3 Gene


Suggested Antigen Peptide Sequences for CPNE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75131
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE3: view

No data available for Gene Families for CPNE3 Gene

Function for CPNE3 Gene

Molecular function for CPNE3 Gene

GENATLAS Biochemistry:
copine 3,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in brain
UniProtKB/Swiss-Prot Function:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity).

Gene Ontology (GO) - Molecular Function for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA 11041869
GO:0005215 transporter activity TAS 9430674
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding TAS 11041869
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CPNE3: view

Phenotypes for CPNE3 Gene

GenomeRNAi human phenotypes for CPNE3:
genes like me logo Genes that share phenotypes with CPNE3: view

Animal Model Products

miRNA for CPNE3 Gene

miRTarBase miRNAs that target CPNE3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPNE3 Gene

Localization for CPNE3 Gene

Subcellular locations from

Jensen Localization Image for CPNE3 Gene COMPARTMENTS Subcellular localization image for CPNE3 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11041869
GO:0005829 cytosol IDA 12949241
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CPNE3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE3 Gene

Pathways for CPNE3 Gene

SuperPathways for CPNE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11041869
GO:0006629 lipid metabolic process TAS 9430674
GO:0006644 phospholipid metabolic process TAS --
GO:0016192 vesicle-mediated transport TAS 9430674
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CPNE3: view

No data available for Pathways by source for CPNE3 Gene

Compounds for CPNE3 Gene

(1) HMDB Compounds for CPNE3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CPNE3: view

Transcripts for CPNE3 Gene

Unigene Clusters for CPNE3 Gene

Copine III:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE3 Gene

No ASD Table

Relevant External Links for CPNE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE3 Gene

mRNA expression in normal human tissues for CPNE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CPNE3 Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE3 Gene

SOURCE GeneReport for Unigene cluster for CPNE3 Gene Hs.191219

mRNA Expression by UniProt/SwissProt for CPNE3 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CPNE3: view

Expression partners for CPNE3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CPNE3 Gene

Orthologs for CPNE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE3 35
  • 90.99 (n)
  • 95.31 (a)
CPNE3 36
  • 95 (a)
(Canis familiaris)
Mammalia CPNE3 35
  • 92.87 (n)
  • 96.25 (a)
CPNE3 36
  • 96 (a)
(Mus musculus)
Mammalia Cpne3 35
  • 89.99 (n)
  • 94.37 (a)
Cpne3 16
Cpne3 36
  • 94 (a)
(Pan troglodytes)
Mammalia CPNE3 35
  • 99.44 (n)
  • 99.26 (a)
CPNE3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cpne3 35
  • 88.62 (n)
  • 92.68 (a)
(Monodelphis domestica)
Mammalia CPNE3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE3 36
  • 89 (a)
(Gallus gallus)
Aves CPNE3 35
  • 79.75 (n)
  • 85.98 (a)
CPNE3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia CPNE3 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne3 35
  • 74.73 (n)
  • 81.43 (a)
Str.3116 35
(Danio rerio)
Actinopterygii cpne3 35
  • 69.19 (n)
  • 76.94 (a)
zgc55622 35
cpne3 36
  • 77 (a)
(Caenorhabditis elegans)
Secernentea T12A7.1 37
  • 43 (a)
Y73F8A.19 37
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BON2 35
  • 50.43 (n)
  • 44.77 (a)
(Oryza sativa)
Liliopsida Os02g0521300 35
  • 49.42 (n)
  • 42.02 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5235 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
-- 36
  • 55 (a)
CSA.7161 36
  • 53 (a)
Species with no ortholog for CPNE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE3 Gene

Gene Tree for CPNE3 (if available)
Gene Tree for CPNE3 (if available)

Paralogs for CPNE3 Gene

Paralogs for CPNE3 Gene

Selected SIMAP similar genes for CPNE3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CPNE3: view

Variants for CPNE3 Gene

Sequence variations from dbSNP and Humsavar for CPNE3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8041 -- 86,561,416(+) TGACA(C/G)AGTAG utr-variant-3-prime
rs997426 -- 86,551,439(+) AATTA(C/T)GGGGC intron-variant
rs1016102 -- 86,550,558(-) ATCAC(A/G)TGAAT intron-variant
rs1044719 -- 86,558,821(+) AGCCA(A/G)TGTCC utr-variant-3-prime
rs1044728 -- 86,560,435(+) CAGCT(C/T)CACAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPNE3 Gene

Variant ID Type Subtype PubMed ID
esv259871 OTHER Complex 20981092
esv2422239 CNV Duplication 17116639

Relevant External Links for CPNE3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE3 Gene

Disorders for CPNE3 Gene

Relevant External Links for CPNE3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CPNE3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CPNE3 Gene

Publications for CPNE3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  5. Characterization of human copine III as a phosphoprotein with associated kinase activity. (PMID: 11041869) Caudell E.G. … Grimm E.A. (Biochemistry 2000) 3 4

Products for CPNE3 Gene

Sources for CPNE3 Gene

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