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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPNE2 Gene

protein-coding   GIFtS: 51
GCID: GC16P057126

Copine II

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Copine II1 2 3
COPN22
CPN22
copine-22

External Ids:    HGNC: 23151   Entrez Gene: 2211842   Ensembl: ENSG000001408487   OMIM: 6042065   UniProtKB: Q96FN43   

Export aliases for CPNE2 gene to outside databases

Previous GC identifers: GC16P047522 GC16P057204 GC16P056861 GC16P056901 GC16P055684 GC16P042996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPNE2 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two
N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis
identified multiple alternatively spliced transcript variants but their full-length natures could not be
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPNE2 Gene: 
CPNE2 (copine II) is a protein-coding gene. Diseases associated with CPNE2 include infertility, and schizophrenia. An important paralog of this gene is CPNE9.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPNE2 gene promoter:
         SRF   E2F-3a   E2F-4   RP58   E2F-5   SRF (504 AA)   E2F-2   E2F-1   E2F   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPNE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CPNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057126:  view genomic region     (about GC identifiers)

Start:
57,126,449 bp from pter      End:
57,181,878 bp from pter
Size:
55,430 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4 (See protein sequence)
Recommended Name: Copine-2  
Size: 548 amino acids; 61190 Da
Secondary accessions: Q68D19 Q86XP9

Explore the universe of human proteins at neXtProt for CPNE2: NX_Q96FN4

Explore proteomics data for CPNE2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FN4

  • CPNE2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPNE2 Protein Expression
    REFSEQ proteins: NP_689940.3  
    ENSEMBL proteins: 
     ENSP00000290776   ENSP00000439018   ENSP00000455883   ENSP00000456042   ENSP00000455443  
     ENSP00000457579   ENSP00000445468  

    Human Recombinant Protein Products for CPNE2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018029 C2_membr_targeting
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR010734 Copine
     IPR000008 C2_Ca-dep
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q96FN4

    ProtoNet protein and cluster: Q96FN4

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CPNE2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPNE2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPNE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPNE2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CPNE2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-181c hsa-miR-548k hsa-miR-381 hsa-miR-181a hsa-miR-4282 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidCPNE2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for CPNE2 (Q96FN42, 3 ENSP000002907764) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248186 I2D: score=2 
    CDKN1AP389362, 3MINT-8251729 I2D: score=2 
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    MYCBPQ994173, ENSP000003807024I2D: score=1 STRING: ENSP00000380702
    RDXP352413, ENSP000003428304I2D: score=1 STRING: ENSP00000342830
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPNE2

    Search CenterWatch for drugs/clinical trials and news about CPNE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPNE2 gene: 
    NM_152727.5  

    Unigene Cluster for CPNE2:

    Copine II
    Hs.339809  [show with all ESTs]
    Unigene Representative Sequence: BC053658
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290776(uc002eks.2 uc010ccu.2) ENST00000535318(uc010cct.2)
    ENST00000566259 ENST00000565874 ENST00000567487 ENST00000565766 ENST00000566042
    ENST00000565951(uc002ekt.1) ENST00000566910 ENST00000567011 ENST00000537605

    miRNA
    Products:
         
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CPNE2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-181c hsa-miR-548k hsa-miR-381 hsa-miR-181a hsa-miR-4282 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidCPNE2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPNE2
    Clone
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    OriGene ORF clones in mouse, rat for CPNE2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPNE2

    Additional mRNA sequence: 

    AF492484.1 AK126138.1 AK292269.1 AK315394.1 BC053658.1 CR749617.1 

    12 DOTS entries:

    DT.100784022  DT.412253  DT.97845560  DT.100030792  DT.120724321  DT.101958208  DT.100774148  DT.310838 
    DT.95332652  DT.120724325  DT.95332660  DT.97845558 

    24/180 AceView cDNA sequences (see all 180):

    BU145674 BF338716 CR604141 CA423614 BC053658 BM680845 BI870404 BQ953772 
    CD251915 BM999070 BU681580 BU197093 CB306539 BQ214847 BG818529 BG288396 
    BM714859 BM977003 BM802843 BM708255 BQ708222 AI139657 Z45986 Z41598 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:        -     -           -                                                                 -     -                 -                                 
    SP2:              -           -                                                                 -     -                 -                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                    -           -                     
    SP5:                                                                                                                    -     -     -                     


    ECgene alternative splicing isoforms for CPNE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPNE2 expression in normal human tissues (normalized intensities)      CPNE2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGCTCACT
    CPNE2 Expression
    About this image


    CPNE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             epididymal fat pads   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             bone marrow-derived macrophages   
     
     Spinal Cord (Nervous System)
             spinal cord/lateral wall/ventricular layer   
     
     Neural Tube (Nervous System)
             spinal cord/lateral wall/ventricular layer   

    See CPNE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPNE2

    SOURCE GeneReport for Unigene cluster: Hs.339809
        SABiosciences Custom PCR Arrays for CPNE2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPNE2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne21 , 5 copine II1, 5 88.63(n)1
    94.53(a)1
      8 (46.55 cM)5
    2345771  NM_153507.21  NP_705727.11 
     945329905 
    chicken
    (Gallus gallus)
    Aves CPNE21 copine II 83.06(n)
    89.65(a)
      415646  XM_003641886.1  XP_003641934.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343677.1(273890-321911)
    zebrafish
    (Danio rerio)
    Actinopterygii cpne21 copine II 74.03(n)
    80.52(a)
      565225  NM_001045075.2  NP_001038540.1 
    corn
    (Zea mays)
    Liliopsida Zm.92802 Zea mays transcribed sequence with moderate similarity more 74.59(n)    146062700 


    ENSEMBL Gene Tree for CPNE2 (if available)
    TreeFam Gene Tree for CPNE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPNE2 gene
    CPNE92  CPNE62  CPNE32  CPNE52  CPNE82  CPNE42  CPNE72  CPNE12  
    8 SIMAP similar genes for CPNE2 using alignment to 5 protein entries:     CPNE2_HUMAN (see all proteins):
    CPNE3    CPNE1    CPNE9    CPNE4    CPNE8    CPNE7
    CPNE6    CPNE5

    CPNE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1176 SNPs in CPNE2 are shown (see all 1176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144471611,2
    C,F--57124511(+) GCGCAA/GTCTTG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs7117581,2
    C,F,A--57124637(+) agtttC/Tgccat 1 -- us2k17Minor allele frequency- T:0.39MN NA CSA EA 313
    rs790175091,2
    F--57124683(+) TAATCG/ACCCGC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1470398201,2
    --57124747(+) TAATTC/TGTACC 1 -- us2k10--------
    rs1817891,2
    C,F,A,H--57124824(+) ggatgG/Aacatt 1 -- us2k117Minor allele frequency- A:0.48NS EA NA WA CSA 1209
    rs613975121,2
    C,F--57124872(+) TGCTAC/TGTACA 1 -- us2k13Minor allele frequency- T:0.15WA CSA 122
    rs1869443421,2
    --57124901(+) GGCCAC/TATGTT 1 -- us2k10--------
    rs1914610461,2
    C--57124918(+) TCTCCC/TGGGTA 1 -- us2k10--------
    rs354090861,2
    C,F--57124997(+) ATCTTC/GCTTGA 1 -- us2k14Minor allele frequency- G:0.12NA EA 126
    rs735488231,2
    C,F--57125072(+) TGGGTC/TTTCTG 1 -- us2k16Minor allele frequency- T:0.13WA CSA NA EA 364

    HapMap Linkage Disequilibrium report for CPNE2 (57126449 - 57181878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CPNE2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522759CNV Loss19592680
    esv22093CNV Loss19812545
    nsv906723CNV Loss21882294
    nsv827683CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE2
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604206    OMIM disorders: --

    2 diseases for CPNE2:    About MalaCards
    infertility    schizophrenia


    CPNE2 for disorders           About GeneDecksing


    Export disorders for CPNE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPNE2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CPNE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3, 9 Creutz C.E.... Cohen J. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221184 HGNC: 2315 AceView: CPNE2 Ensembl:ENSG00000140848 euGenes: HUgn221184
    ECgene: CPNE2 H-InvDB: CPNE2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPNE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPNE2 gene:
    Search GeneIP for patents involving CPNE2

    GeneCards and IP:
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