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Aliases for CPNE2 Gene

Aliases for CPNE2 Gene

  • Copine II 2 3 4
  • CPN2 3 6
  • Copine-2 3
  • COPN2 3

External Ids for CPNE2 Gene

Previous GeneCards Identifiers for CPNE2 Gene

  • GC16P047522
  • GC16P057204
  • GC16P056861
  • GC16P056901
  • GC16P055684
  • GC16P042996

Summaries for CPNE2 Gene

Entrez Gene Summary for CPNE2 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE2 Gene

CPNE2 (Copine II) is a Protein Coding gene. An important paralog of this gene is CPNE7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE2 Gene

Genomics for CPNE2 Gene

Regulatory Elements for CPNE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPNE2 Gene

57,092,537 bp from pter
57,148,367 bp from pter
55,831 bases
Plus strand

Genomic View for CPNE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE2 Gene

Proteins for CPNE2 Gene

  • Protein details for CPNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q68D19
    • Q719H8
    • Q86XP9

    Protein attributes for CPNE2 Gene

    548 amino acids
    Molecular mass:
    61190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE2 Gene


neXtProt entry for CPNE2 Gene

Proteomics data for CPNE2 Gene at MOPED

Post-translational modifications for CPNE2 Gene

  • Ubiquitination at Lys92
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE2 Gene

Antibody Products

No data available for DME Specific Peptides for CPNE2 Gene

Domains for CPNE2 Gene

Gene Families for CPNE2 Gene

Protein Domains for CPNE2 Gene


Suggested Antigen Peptide Sequences for CPNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the copine family.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE2: view

Function for CPNE2 Gene

Gene Ontology (GO) - Molecular Function for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CPNE2: view

Animal Model Products

miRNA for CPNE2 Gene

miRTarBase miRNAs that target CPNE2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE2 Gene

Localization for CPNE2 Gene

Subcellular locations from

Jensen Localization Image for CPNE2 Gene COMPARTMENTS Subcellular localization image for CPNE2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE2 Gene

Pathways for CPNE2 Gene

SuperPathways for CPNE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE2 Gene


No data available for Pathways by source for CPNE2 Gene

Transcripts for CPNE2 Gene

Unigene Clusters for CPNE2 Gene

Copine II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - - -
SP4: - -
SP5: - - -
SP7: - - - - - - - - - - - - - - -
SP8: -

Relevant External Links for CPNE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE2 Gene

mRNA expression in normal human tissues for CPNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CPNE2 Gene

This gene is overexpressed in Serum (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE2 Gene

SOURCE GeneReport for Unigene cluster for CPNE2 Gene Hs.339809

genes like me logo Genes that share expressions with CPNE2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for CPNE2 Gene

Orthologs for CPNE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE2 35
  • 92.64 (n)
  • 96.72 (a)
CPNE2 36
  • 96 (a)
(Canis familiaris)
Mammalia CPNE2 35
  • 92.46 (n)
  • 97.08 (a)
CPNE2 36
  • 97 (a)
(Mus musculus)
Mammalia Cpne2 35
  • 89.29 (n)
  • 95.46 (a)
Cpne2 16
Cpne2 36
  • 95 (a)
(Pan troglodytes)
Mammalia CPNE2 35
  • 99.64 (n)
  • 99.64 (a)
CPNE2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpne2 35
  • 88.72 (n)
  • 95.84 (a)
(Monodelphis domestica)
Mammalia CPNE2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE2 36
  • 91 (a)
(Gallus gallus)
Aves CPNE2 35
  • 83.36 (n)
  • 90.55 (a)
CPNE2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia CPNE2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne2 35
  • 73.31 (n)
  • 84.44 (a)
(Danio rerio)
Actinopterygii cpne2 35
  • 74.32 (n)
  • 80.65 (a)
cpne2 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13834 35
(Triticum aestivum)
Liliopsida Ta.1560 35
(Zea mays)
Liliopsida Zm.9280 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
-- 36
  • 54 (a)
CSA.7161 36
  • 49 (a)
Species with no ortholog for CPNE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CPNE2 Gene

Gene Tree for CPNE2 (if available)
Gene Tree for CPNE2 (if available)

Paralogs for CPNE2 Gene

Paralogs for CPNE2 Gene

(8) SIMAP similar genes for CPNE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPNE2: view

Variants for CPNE2 Gene

Sequence variations from dbSNP and Humsavar for CPNE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs6499866 -- 57,142,737(+) CCTGG(A/G)AATTC intron-variant
rs5817089 -- 57,111,183(+) ATATC(-/T)TTTTT intron-variant
rs5817088 -- 57,111,114(+) ACTTT(-/G)TGTTT intron-variant
rs4784775 -- 57,134,320(+) AAGGC(A/G)GGCTC intron-variant
rs4784774 -- 57,131,148(+) GGCAG(A/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE2 Gene

Variant ID Type Subtype PubMed ID
nsv827683 CNV Loss 20364138
nsv906723 CNV Loss 21882294
esv22093 CNV Loss 19812545
nsv522759 CNV Loss 19592680

Relevant External Links for CPNE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE2 Gene

Disorders for CPNE2 Gene

No disorders were found for CPNE2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CPNE2 Gene

Publications for CPNE2 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 3
  4. Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. (PMID: 20381070) Martins-de-Souza D. … Turck C.W. (J Psychiatr Res 2010) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for CPNE2 Gene

Sources for CPNE2 Gene

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