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Aliases for CPNE2 Gene

Aliases for CPNE2 Gene

  • Copine II 2 3 4
  • COPN2 3
  • CPN2 3

External Ids for CPNE2 Gene

Previous GeneCards Identifiers for CPNE2 Gene

  • GC16P047522
  • GC16P057204
  • GC16P056861
  • GC16P056901
  • GC16P055684
  • GC16P042996

Summaries for CPNE2 Gene

Entrez Gene Summary for CPNE2 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE2 Gene

CPNE2 (Copine II) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE2 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE2 Gene

Genomics for CPNE2 Gene

Regulatory Elements for CPNE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPNE2 Gene

Chromosome:
16
Start:
57,092,537 bp from pter
End:
57,148,369 bp from pter
Size:
55,833 bases
Orientation:
Plus strand

Genomic View for CPNE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE2 Gene

Proteins for CPNE2 Gene

  • Protein details for CPNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN4-CPNE2_HUMAN
    Recommended name:
    Copine-2
    Protein Accession:
    Q96FN4
    Secondary Accessions:
    • Q68D19
    • Q719H8
    • Q86XP9

    Protein attributes for CPNE2 Gene

    Size:
    548 amino acids
    Molecular mass:
    61190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE2 Gene

Proteomics data for CPNE2 Gene at MOPED

Post-translational modifications for CPNE2 Gene

  • Ubiquitination at Lys 92
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE2 Gene

No data available for DME Specific Peptides for CPNE2 Gene

Domains & Families for CPNE2 Gene

Gene Families for CPNE2 Gene

Protein Domains for CPNE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN4

UniProtKB/Swiss-Prot:

CPNE2_HUMAN :
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
  • Belongs to the copine family.
Domain:
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE2: view

Function for CPNE2 Gene

Molecular function for CPNE2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

Gene Ontology (GO) - Molecular Function for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CPNE2: view

Phenotypes for CPNE2 Gene

genes like me logo Genes that share phenotypes with CPNE2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE2 Gene

Localization for CPNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE2 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane. {ECO:0000250 UniProtKB:P59108}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE2 Gene COMPARTMENTS Subcellular localization image for CPNE2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE2: view

Pathways & Interactions for CPNE2 Gene

SuperPathways for CPNE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071277 cellular response to calcium ion IEA --
genes like me logo Genes that share ontologies with CPNE2: view

No data available for Pathways by source and SIGNOR curated interactions for CPNE2 Gene

Drugs & Compounds for CPNE2 Gene

No Compound Related Data Available

Transcripts for CPNE2 Gene

Unigene Clusters for CPNE2 Gene

Copine II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: -

Relevant External Links for CPNE2 Gene

GeneLoc Exon Structure for
CPNE2
ECgene alternative splicing isoforms for
CPNE2

Expression for CPNE2 Gene

mRNA expression in normal human tissues for CPNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE2 Gene

This gene is overexpressed in Serum (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE2 Gene



SOURCE GeneReport for Unigene cluster for CPNE2 Gene Hs.339809

mRNA Expression by UniProt/SwissProt for CPNE2 Gene

Q96FN4-CPNE2_HUMAN
Tissue specificity: Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241)
genes like me logo Genes that share expression patterns with CPNE2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CPNE2 Gene

Orthologs for CPNE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPNE2 35
  • 92.64 (n)
  • 96.72 (a)
CPNE2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE2 35
  • 92.46 (n)
  • 97.08 (a)
CPNE2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne2 35
  • 89.29 (n)
  • 95.46 (a)
Cpne2 16
Cpne2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPNE2 35
  • 99.64 (n)
  • 99.64 (a)
CPNE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne2 35
  • 88.72 (n)
  • 95.84 (a)
oppossum
(Monodelphis domestica)
Mammalia CPNE2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPNE2 35
  • 83.36 (n)
  • 90.55 (a)
CPNE2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPNE2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne2 35
  • 73.31 (n)
  • 84.44 (a)
zebrafish
(Danio rerio)
Actinopterygii cpne2 35
  • 74.32 (n)
  • 80.65 (a)
cpne2 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13834 35
wheat
(Triticum aestivum)
Liliopsida Ta.1560 35
corn
(Zea mays)
Liliopsida Zm.9280 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
CSA.7161 36
  • 49 (a)
ManyToMany
Species with no ortholog for CPNE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CPNE2 Gene

ENSEMBL:
Gene Tree for CPNE2 (if available)
TreeFam:
Gene Tree for CPNE2 (if available)

Paralogs for CPNE2 Gene

Paralogs for CPNE2 Gene

(8) SIMAP similar genes for CPNE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPNE2: view

Variants for CPNE2 Gene

Sequence variations from dbSNP and Humsavar for CPNE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs158619 -- 57,116,594(-) TCTAG(G/T)TGGAA intron-variant
rs169726 -- 57,139,059(-) gctct(C/G)tgtga intron-variant
rs173897 -- 57,126,526(-) CCTTC(A/C/T)CTGAC intron-variant
rs181789 -- 57,090,912(+) ggatg(A/G)acatt upstream-variant-2KB
rs289721 -- 57,091,454(+) GGTGA(A/G)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPNE2 Gene

Variant ID Type Subtype PubMed ID
nsv827683 CNV Loss 20364138
nsv906723 CNV Loss 21882294
esv22093 CNV Loss 19812545
nsv522759 CNV Loss 19592680

Variation tolerance for CPNE2 Gene

Residual Variation Intolerance Score: 19.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE2 Gene

HapMap Linkage Disequilibrium report
CPNE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE2 Gene

Disorders for CPNE2 Gene

Relevant External Links for CPNE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE2
genes like me logo Genes that share disorders with CPNE2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE2 Gene

Publications for CPNE2 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67

Products for CPNE2 Gene

Sources for CPNE2 Gene

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