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CPNE2 Gene

protein-coding   GIFtS: 50
GCID: GC16P057126

Copine II

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Copine II1 2 3
CPN22 5
COPN22
copine-22

External Ids:    HGNC: 23151   Entrez Gene: 2211842   Ensembl: ENSG000001408487   OMIM: 6042065   UniProtKB: Q96FN43   

Export aliases for CPNE2 gene to outside databases

Previous GC identifers: GC16P047522 GC16P057204 GC16P056861 GC16P056901 GC16P055684 GC16P042996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPNE2 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two
N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis
identified multiple alternatively spliced transcript variants but their full-length natures could not be
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPNE2 Gene:
CPNE2 (copine II) is a protein-coding gene. Diseases associated with CPNE2 include epididymitis, and infertility. An important paralog of this gene is CPNE9.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPNE2 gene promoter:
         SRF   E2F-3a   E2F-4   RP58   E2F-5   SRF (504 AA)   E2F-2   E2F-1   E2F   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE2 promoter sequence
   Search Chromatin IP Primers for CPNE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPNE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CPNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057126:  view genomic region     (about GC identifiers)

Start:
57,126,449 bp from pter      End:
57,181,878 bp from pter
Size:
55,430 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4 (See protein sequence)
Recommended Name: Copine-2  
Size: 548 amino acids; 61190 Da
Secondary accessions: Q68D19 Q86XP9

Explore the universe of human proteins at neXtProt for CPNE2: NX_Q96FN4

Explore proteomics data for CPNE2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys92
  • Modification sites at PhosphoSitePlus

  • See CPNE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689940.3  
    ENSEMBL proteins: 
     ENSP00000290776   ENSP00000439018   ENSP00000455883   ENSP00000456042   ENSP00000455443  
     ENSP00000457579   ENSP00000445468  

    CPNE2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPNE2

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    CPNE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CPNE2
    Cloud-Clone Corp. CLIAs for CPNE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010734 Copine
     IPR000008 C2_dom
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q96FN4

    ProtoNet protein and cluster: Q96FN4

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CPNE2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPNE2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE2

    miRNA
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    miRTarBase miRNAs that target CPNE2:
    hsa-mir-7-5p (MIRT025805)

    Block miRNA regulation of human, mouse, rat CPNE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-181c hsa-miR-548k hsa-miR-381 hsa-miR-181a hsa-miR-4282 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidCPNE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPNE2
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CPNE2

    Clone
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    OriGene clones in human, mouse for CPNE2 (see all 8)
    OriGene ORF clones in mouse, rat for CPNE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE2 (NM_152727)
    Sino Biological Human cDNA Clone for CPNE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPNE2
    Interactions:

        Search GeneGlobe Interaction Network for CPNE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CPNE2 (Q96FN42, 3 ENSP000002907764) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248186 I2D: score=2 
    CDKN1AP389362, 3MINT-8251729 I2D: score=2 
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    MYCBPQ994173, ENSP000003807024I2D: score=1 STRING: ENSP00000380702
    RDXP352413, ENSP000003428304I2D: score=1 STRING: ENSP00000342830
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPNE2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPNE2 gene: 
    NM_152727.5  

    Unigene Cluster for CPNE2:

    Copine II
    Hs.339809  [show with all ESTs]
    Unigene Representative Sequence: BC053658
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290776(uc002eks.2 uc010ccu.2) ENST00000535318(uc010cct.2)
    ENST00000566259 ENST00000565874 ENST00000567487 ENST00000565766 ENST00000566042
    ENST00000565951(uc002ekt.1) ENST00000566910 ENST00000567011 ENST00000537605

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPNE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPNE2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-181c hsa-miR-548k hsa-miR-381 hsa-miR-181a hsa-miR-4282 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidCPNE2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPNE2
    Predesigned siRNA for gene silencing in human, mouse, rat CPNE2
    Clone
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    OriGene clones in human, mouse for CPNE2 (see all 8)
    OriGene ORF clones in mouse, rat for CPNE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPNE2 (NM_152727)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPNE2
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPNE2
      QuantiTect SYBR Green Assays in human, mouse, rat CPNE2
      QuantiFast Probe-based Assays in human, mouse, rat CPNE2

    Additional mRNA sequence: 

    AF492484.1 AK126138.1 AK292269.1 AK315394.1 BC053658.1 CR749617.1 

    12 DOTS entries:

    DT.100784022  DT.412253  DT.97845560  DT.100030792  DT.120724321  DT.101958208  DT.100774148  DT.310838 
    DT.95332652  DT.120724325  DT.95332660  DT.97845558 

    Selected AceView cDNA sequences (see all 180):

    CD251915 BQ953772 BF338716 BM684661 AI139657 BM708255 BQ230271 BI870404 
    BG818529 Z41598 BU197093 BM999070 CA440832 BQ214847 BM977003 BG288396 
    BU681580 BQ708222 BU145674 Z45986 BM680845 CA423614 BU731343 BQ682640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:        -     -           -                                                                 -     -                 -                                 
    SP2:              -           -                                                                 -     -                 -                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                    -           -                     
    SP5:                                                                                                                    -     -     -                     


    ECgene alternative splicing isoforms for CPNE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPNE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGCTCACT
    CPNE2 Expression
    About this image


    CPNE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    CPNE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPNE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.339809
        Custom PCR Arrays for CPNE2
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    QuantiFast Probe-based Assays in human, mouse, rat CPNE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPNE2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne21 , 5 copine II1, 5 89.29(n)1
    95.46(a)1
      8 (46.55 cM)5
    2345771  NM_153507.21  NP_705727.11 
     945329905 
    chicken
    (Gallus gallus)
    Aves CPNE21 copine II 83.36(n)
    90.55(a)
      415646  NM_001278011.1  NP_001264940.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE26
    copine II
    86(a)
    1 ↔ 1
    GL343677.1(273890-321911)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cpne21 copine II 73.31(n)
    84.44(a)
      100495261  XM_002934799.1  XP_002934845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpne21 copine II 74.32(n)
    80.65(a)
      565225  NM_001045075.2  NP_001038540.1 
    corn
    (Zea mays)
    Liliopsida Zm.92802 Zea mays transcribed sequence with moderate similarity more 74.59(n)    146062700 


    ENSEMBL Gene Tree for CPNE2 (if available)
    TreeFam Gene Tree for CPNE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPNE2 gene
    CPNE92  CPNE62  CPNE32  CPNE52  CPNE82  CPNE42  CPNE72  CPNE12  
    8 SIMAP similar genes for CPNE2 using alignment to 5 protein entries:     CPNE2_HUMAN (see all proteins):
    CPNE3    CPNE1    CPNE9    CPNE4    CPNE8    CPNE7
    CPNE6    CPNE5

    CPNE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPNE2 (see all 1176)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144471611,2
    C,F--57124511(+) GCGCAA/GTCTTG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs7117581,2
    C,F,A--57124637(+) agtttC/Tgccat 1 -- us2k17Minor allele frequency- T:0.39MN NA CSA EA 313
    rs790175091,2
    F--57124683(+) TAATCG/ACCCGC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1470398201,2
    --57124747(+) TAATTC/TGTACC 1 -- us2k10--------
    rs1817891,2
    C,F,A,H--57124824(+) ggatgG/Aacatt 1 -- us2k117Minor allele frequency- A:0.48NS EA NA WA CSA 1209
    rs613975121,2
    C,F--57124872(+) TGCTAC/TGTACA 1 -- us2k13Minor allele frequency- T:0.15WA CSA 122
    rs1869443421,2
    --57124901(+) GGCCAC/TATGTT 1 -- us2k10--------
    rs1914610461,2
    C--57124918(+) TCTCCC/TGGGTA 1 -- us2k10--------
    rs354090861,2
    C,F--57124997(+) ATCTTC/GCTTGA 1 -- us2k14Minor allele frequency- G:0.12NA EA 126
    rs735488231,2
    C,F--57125072(+) TGGGTC/TTTCTG 1 -- us2k16Minor allele frequency- T:0.13WA CSA NA EA 364

    HapMap Linkage Disequilibrium report for CPNE2 (57126449 - 57181878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CPNE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522759CNV Loss19592680
    esv22093CNV Loss19812545
    nsv906723CNV Loss21882294
    nsv827683CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPNE2
    DNA2.0 Custom Variant and Variant Library Synthesis for CPNE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604206    OMIM disorders: --

    3 diseases for CPNE2:    
    About MalaCards
    epididymitis    infertility    schizophrenia


    CPNE2 for disorders           About GeneDecksing


    Export disorders for CPNE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPNE2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CPNE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 3, 9 Creutz C.E.... Cohen J. (J. Biol. Chem. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221184 HGNC: 2315 AceView: CPNE2 Ensembl:ENSG00000140848 euGenes: HUgn221184
    ECgene: CPNE2 H-InvDB: CPNE2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPNE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPNE2 gene:
    Search GeneIP for patents involving CPNE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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