CPNE2 Gene
protein-coding GIFtS : 48
GCID: GC16 P057126
copine II
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Aliasesfor CPNE2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Copine II 1 2 3 CPN21 2 COPN22 Copine-21
Export aliases for CPNE2 gene to outside databases Previous GC identifers: GC16P047522 GC16P057204 GC16P056861 GC16P056901 GC16P055684 GC16P042996
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Summariesfor CPNE2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CPNE2 : Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor CPNE2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPNE2 gene promoter: SRF E2F-3a E2F-4 RP58 E2F-5 SRF (504 AA) E2F-2 E2F-1 E2F Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for CPNE2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CPNE2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13 CPNE2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P057126: view genomic region
(about GC identifiers )
Start:
57,126,449 bp from pter
End:
57,181,878 bp from pter
Size:
55,430 bases
Orientation:
plus strand
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Proteinsfor CPNE2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4 (See
protein sequence )Recommended Name: Copine-2 Size : 548 amino acids; 61190 Da
Secondary accessions : Q68D19 Q86XP9Explore the universe of human proteins at neXtProt for CPNE2: NX_Q96FN4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96FN4 CPNE2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689940.3 ENSEMBL proteins: ENSP00000290776 ENSP00000439018 ENSP00000455883 ENSP00000456042 ENSP00000455443 ENSP00000457579 ENSP00000445468 Human Recombinant Protein Products: CPNE2 Antibody Products: Assay Products for CPNE2:
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Protein
Domains / Familiesfor CPNE2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CPNE2 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96FN4 ProtoNet protein and cluster: Q96FN4
2 Blocks protein families : IPB000008 C2 domain IPB010734 Copine UniProtKB/Swiss-Prot: CPNE2_HUMAN, Q96FN4 Similarity : Belongs to the copine familySimilarity : Contains 2 C2 domainsSimilarity : Contains 1 VWFA domain
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Functionfor CPNE2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPNE2 (NM_152727 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2
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Pathways & Interactionsfor CPNE2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPNE2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)5/16 Interacting proteins for CPNE2 (Q96FN4 2 , 3 ENSP00000290776 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 16 )About this table
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Drugs & Compoundsfor CPNE2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CPNE2 Search CenterWatch for drugs/clinical trials and news about CPNE2
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Transcriptsfor CPNE2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CPNE2 gene: NM_152727.5 Unigene Cluster for CPNE2:
Copine II Hs.339809 [show with all ESTs ] Unigene Representative Sequence: BC053658 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000290776 (uc002eks.2 uc010ccu.2 ) ENST00000535318 (uc010cct.2 )ENST00000566259 ENST00000565874 ENST00000567487 ENST00000565766 ENST00000566042 ENST00000565951 (uc002ekt.1 ) ENST00000566910 ENST00000567011 ENST00000537605 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPNE2 (NM_152727 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPNE2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE2
Additional cDNA sequence: AF492484.1 AK126138.1 AK292269.1 AK315394.1 BC053658.1 CR749617.1
13 DOTS entries : DT.100784022 DT.412253
DT.97845560 DT.100030792 DT.120724321 DT.101958208 DT.100774148 DT.310838 DT.95332652 DT.120724325 DT.95072751 DT.95332660 DT.97845558 24/180 AceView cDNA sequences (see all 180 ):
BQ932722 BQ953772 BU681580 BM999070 BI870404 CD251915 CA423614 BC053658 BM680845 CR604141 AA669691 BM684661 CB242280 NM_152727 BF732834 BQ682640 BU731343 CA438102 BF338716 BU145674 BU191065 CA440832 BQ230271 Z41598 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 SP1 :   -   -     -                       -   -       -             SP2 :     -     -                       -   -       -             SP3 :                                                   SP4 :                                       -     -         SP5 :                                       -   -   -        
ECgene alternative splicing isoforms for CPNE2
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Expression for CPNE2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CPNE2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CACGCTCACT
About this image CPNE2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Spinal Cord Presumptive Spinal Cord Spinal Cord Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CPNE2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CPNE2 SOURCE GeneReport for Unigene cluster: Hs.339809 SABiosciences Custom PCR Arrays for CPNE2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPNE2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CPNE2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPNE2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPNE2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2
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Orthologsfor CPNE2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CPNE2 gene from 6/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for CPNE2 (if available)TreeFam Gene Tree for CPNE2 (if available)
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Paralogsfor CPNE2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CPNE2 gene CPNE9 2 CPNE6 2 CPNE3 2 CPNE5 2 CPNE8 2 CPNE4 2 CPNE7 2 CPNE1 2 8 SIMAP similar genes for CPNE2 using alignment to 5 protein entries: CPNE2_HUMAN (see all proteins ):CPNE3 CPNE1 CPNE9 CPNE4 CPNE8 CPNE7 CPNE6 CPNE5
CPNE2 for paralogs About GeneDecksing
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Genomic Variantsfor CPNE2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CPNE2 (57126449 - 57181878 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CPNE2 1 CNV : 67003
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPNE2
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Disorders
/ Diseasesfor CPNE2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CPNE2 for disorders About GeneDecksing
OMIM gene information: 604206
OMIM disorders : --3 diseases for CPNE2 : About MalaCards hermaphroditism infertility schizophrenia Export disorders for CPNE2 gene to outside databases
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Publicationsfor CPNE2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CPNE2 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with CPNE2) Utopia : connect your pdf to the dynamic world of online information
The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674) 1 , 3, 9 Creutz C.E.... Cohen J. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950) 1 Lee O.H....Songyang Z. (2011) Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070) 1 Martins-de-Souza D....Turck C.W. (2010) Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747) 1 Fenner B.J....Prehn J.H. (2010)
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External Searches for CPNE2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CPNE2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CPNE2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CPNE2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CPNE2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CPNE2 gene: Search GeneIP for patents involving CPNE2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CPNE2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CPNE2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CPNE2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPNE2 OriGene Protein Over-expression Lysate for CPNE2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CPNE2 OriGene 3'-UTR Clone for CPNE2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPNE2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CPNE2 OriGene Custom Protein Services for CPNE2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPNE2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPNE2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CPNE2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CPNE2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPNE2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPNE2
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CPNE2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPNE2
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Aliases for CPNE2
Databases for CPNE2
Disorders / Diseases for CPNE2
Domains / Families for CPNE2
Drugs / Compounds for CPNE2
Expression for CPNE2
Function for CPNE2
Genomic Views for CPNE2
Intellectual Property for CPNE2
Orthologs for CPNE2
Paralogs for CPNE2
Pathways / Interactions for CPNE2
Products for CPNE2
Proteins for CPNE2
Publications for CPNE2
Search Box for CPNE2
Summaries for CPNE2
Transcripts for CPNE2
Variants for CPNE2
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