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Aliases for CPNE2 Gene

Aliases for CPNE2 Gene

  • Copine 2 2 3 5
  • Copine II 2 3 4
  • Copine-2 3
  • COPN2 3
  • CPN2 3

External Ids for CPNE2 Gene

Previous GeneCards Identifiers for CPNE2 Gene

  • GC16P047522
  • GC16P057204
  • GC16P056861
  • GC16P056901
  • GC16P055684
  • GC16P042996

Summaries for CPNE2 Gene

Entrez Gene Summary for CPNE2 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE2 Gene

CPNE2 (Copine 2) is a Protein Coding gene. An important paralog of this gene is CPNE3.

UniProtKB/Swiss-Prot for CPNE2 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE2 Gene

Genomics for CPNE2 Gene

Regulatory Elements for CPNE2 Gene

Enhancers for CPNE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G057069 1.3 Ensembl ENCODE dbSUPER 19.6 -21.0 -20953 3.6 HDGF PCBP1 EGR2 ZNF263 SMARCA5 USF2 ZNF623 TBX21 NR2F2 NFIC CPNE2 NLRC5 CETP RSPRY1 FAM192A ENSG00000260145 ENSG00000260148
GH16G057123 0.9 ENCODE dbSUPER 26.9 +31.5 31545 1.2 BCOR ZMYM3 USF2 FOSL1 RAD51 JUND NFIC SMARCA4 HMBOX1 PRDM10 CPNE2 LOC105371289 GC16P057096
GH16G057132 1.3 Ensembl ENCODE dbSUPER 13.3 +41.8 41783 4.6 CTCF PKNOX1 PLRG1 EBF1 RAD21 ZNF316 ZNF366 ZNF143 SMC3 IKZF2 FAM192A NUDT21 CPNE2 RSPRY1 PLLP LOC105371289 GC16P057096
GH16G057146 1.2 Ensembl ENCODE dbSUPER 13.6 +55.5 55487 3.5 CTCF STAT1 MAX ZIC2 ZNF491 NR2F2 ETS1 ZNF121 SCRT2 ZBTB33 FAM192A PLLP CPNE2 RSPRY1 ENSG00000261114 ENSG00000279019
GH16G057150 0.8 ENCODE dbSUPER 12.6 +58.3 58267 0.2 CTCF POLR2A MLLT1 ZBTB33 CPNE2 ENSG00000279019 RSPRY1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPNE2 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086372 163 1401 PKNOX1 ATF1 RB1 FUS ZBTB40 RAD21 ZNF23 GLIS2 EGR1 FOS

Genomic Location for CPNE2 Gene

Chromosome:
16
Start:
57,092,537 bp from pter
End:
57,148,369 bp from pter
Size:
55,833 bases
Orientation:
Plus strand

Genomic View for CPNE2 Gene

Genes around CPNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE2 Gene

Proteins for CPNE2 Gene

  • Protein details for CPNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN4-CPNE2_HUMAN
    Recommended name:
    Copine-2
    Protein Accession:
    Q96FN4
    Secondary Accessions:
    • Q68D19
    • Q719H8
    • Q86XP9

    Protein attributes for CPNE2 Gene

    Size:
    548 amino acids
    Molecular mass:
    61190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE2 Gene

Post-translational modifications for CPNE2 Gene

  • Ubiquitination at Lys92
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE2 Gene

No data available for DME Specific Peptides for CPNE2 Gene

Domains & Families for CPNE2 Gene

Gene Families for CPNE2 Gene

Protein Domains for CPNE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN4

UniProtKB/Swiss-Prot:

CPNE2_HUMAN :
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
  • Belongs to the copine family.
Domain:
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE2: view

Function for CPNE2 Gene

Molecular function for CPNE2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

Gene Ontology (GO) - Molecular Function for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with CPNE2: view
genes like me logo Genes that share phenotypes with CPNE2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE2 Gene

Localization for CPNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE2 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane. {ECO:0000250 UniProtKB:P59108}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPNE2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPNE2: view

Pathways & Interactions for CPNE2 Gene

SuperPathways for CPNE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071277 cellular response to calcium ion IEA --
genes like me logo Genes that share ontologies with CPNE2: view

No data available for Pathways by source and SIGNOR curated interactions for CPNE2 Gene

Drugs & Compounds for CPNE2 Gene

No Compound Related Data Available

Transcripts for CPNE2 Gene

Unigene Clusters for CPNE2 Gene

Copine II:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: -

Relevant External Links for CPNE2 Gene

GeneLoc Exon Structure for
CPNE2
ECgene alternative splicing isoforms for
CPNE2

Expression for CPNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE2 Gene

This gene is overexpressed in Serum (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPNE2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CPNE2 Gene:

CPNE2

SOURCE GeneReport for Unigene cluster for CPNE2 Gene:

Hs.339809

mRNA Expression by UniProt/SwissProt for CPNE2 Gene:

Q96FN4-CPNE2_HUMAN
Tissue specificity: Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241).

Evidence on tissue expression from TISSUES for CPNE2 Gene

  • Nervous system(4.5)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with CPNE2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE2 Gene

Orthologs for CPNE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE2 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia CPNE2 34 35
  • 92.64 (n)
dog
(Canis familiaris)
Mammalia CPNE2 34 35
  • 92.46 (n)
oppossum
(Monodelphis domestica)
Mammalia CPNE2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne2 34 16 35
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Cpne2 34
  • 88.72 (n)
chicken
(Gallus gallus)
Aves CPNE2 34 35
  • 83.36 (n)
lizard
(Anolis carolinensis)
Reptilia CPNE2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne2 34
  • 73.31 (n)
zebrafish
(Danio rerio)
Actinopterygii cpne2 34 35
  • 74.32 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13834 34
wheat
(Triticum aestivum)
Liliopsida Ta.1560 34
corn
(Zea mays)
Liliopsida Zm.9280 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
ManyToMany
CSA.7161 35
  • 49 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
Species where no ortholog for CPNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CPNE2 Gene

ENSEMBL:
Gene Tree for CPNE2 (if available)
TreeFam:
Gene Tree for CPNE2 (if available)

Paralogs for CPNE2 Gene

Paralogs for CPNE2 Gene

(8) SIMAP similar genes for CPNE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPNE2: view

Variants for CPNE2 Gene

Sequence variations from dbSNP and Humsavar for CPNE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000045987 -- 57,137,061(+) GTAAG(C/G)ATGAA intron-variant, upstream-variant-2KB
rs1000052790 -- 57,096,164(+) CCTCT(C/T)GAGTC intron-variant
rs1000108318 -- 57,130,806(+) CCAGC(A/G)TGGAA intron-variant
rs1000140294 -- 57,122,349(+) CGCTG(C/T)TCTCC intron-variant
rs1000222627 -- 57,131,038(+) ATGCT(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE2 Gene

Variant ID Type Subtype PubMed ID
dgv5138n54 CNV gain 21841781
dgv5139n54 CNV loss 21841781
dgv5140n54 CNV gain 21841781
dgv5141n54 CNV gain+loss 21841781
esv22093 CNV loss 19812545
esv3553471 CNV deletion 23714750
nsv1113811 CNV deletion 24896259
nsv522759 CNV loss 19592680
nsv572704 CNV gain 21841781
nsv572716 CNV loss 21841781
nsv827683 CNV loss 20364138

Variation tolerance for CPNE2 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPNE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE2 Gene

Disorders for CPNE2 Gene

Relevant External Links for CPNE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE2

No disorders were found for CPNE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE2 Gene

Publications for CPNE2 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. (PMID: 12949241) Cowland J.B. … Lollike K. (J. Leukoc. Biol. 2003) 3 4 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CPNE2 Gene

Sources for CPNE2 Gene

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