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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPNE1 Gene

protein-coding   GIFtS: 56
GCID: GC20M034213

Copine I

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Copine I1 2 3
CPN12 3
COPN12
copine-12

External Ids:    HGNC: 23141   Entrez Gene: 89042   Ensembl: ENSG000002140787   OMIM: 6042055   UniProtKB: Q998293   
ORGUL members:         
NONCODE14:n410326      

Export aliases for CPNE1 gene to outside databases

Previous GC identifers: GC20M033972 GC20M033934 GC20M034883 GC20M034929 GC20M033677 GC20M030991


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPNE1 Gene:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane
and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains
and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a
predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may
function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location
20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. (provided by
RefSeq, Aug 2008)

GeneCards Summary for CPNE1 Gene: 
CPNE1 (copine I) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CPNE1 include sporadic breast cancer, and glaucoma. GO annotations related to this gene include phosphatidylserine binding and transporter activity. An important paralog of this gene is CPNE9.

UniProtKB/Swiss-Prot: CPNE1_HUMAN, Q99829
Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties

Gene Wiki entry for CPNE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPNE1 gene promoter:
         STAT1   Sox5   CUTL1   STAT1alpha   HFH-1   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPNE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPNE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPNE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

CPNE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPNE1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M034213:  view genomic region     (about GC identifiers)

Start:
34,213,953 bp from pter      End:
34,252,878 bp from pter
Size:
38,926 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPNE1_HUMAN, Q99829 (See protein sequence)
Recommended Name: Copine-1  
Size: 537 amino acids; 59059 Da
Subunit: Interacts with CCDC22 (By similarity)
Secondary accessions: E1P5Q4 Q6IBL3 Q9H243 Q9NTZ7

Explore the universe of human proteins at neXtProt for CPNE1: NX_Q99829

Explore proteomics data for CPNE1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99829

  • CPNE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPNE1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001185792.1  NP_003906.2  NP_690902.1  NP_690903.1  NP_690904.1  NP_690905.1  

    ENSEMBL proteins: 
     ENSP00000336945   ENSP00000396069   ENSP00000317257   ENSP00000380584   ENSP00000386067  
     ENSP00000415597   ENSP00000390626   ENSP00000416962   ENSP00000404355   ENSP00000389662  
     ENSP00000387434   ENSP00000409305   ENSP00000401915   ENSP00000409794   ENSP00000397638  
     ENSP00000390141   ENSP00000391483   ENSP00000409955   ENSP00000412806   ENSP00000326126  
     ENSP00000380588   ENSP00000380587   ENSP00000380585  

    Human Recombinant Protein Products for CPNE1: 
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    Novus Biologicals CPNE1 Proteins
    Novus Biologicals CPNE1 Lysates
    Sino Biological Recombinant Protein for CPNE1
    Sino Biological Cell Lysate for CPNE1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPNE1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    CPNE1 for ontologies           About GeneDecksing



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    Assay Products for CPNE1: 
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    Cloud-Clone Corp. ELISAs for CPNE1 
    Cloud-Clone Corp. CLIAs for CPNE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018029 C2_membr_targeting
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR010734 Copine
     IPR000008 C2_Ca-dep
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q99829

    ProtoNet protein and cluster: Q99829

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB010734 Copine


    UniProtKB/Swiss-Prot: CPNE1_HUMAN, Q99829
    Similarity: Belongs to the copine family
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 VWFA domain


    CPNE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPNE1_HUMAN, Q99829
    Function: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties

         Genatlas biochemistry entry for CPNE1:
    copine 1,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane
    trafficking,expressed in brain,fetal liver and heart

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA9430674
    GO:0005215transporter activity TAS9430674
    GO:0005515protein binding ----
    GO:0005544calcium-dependent phospholipid binding TAS9430674
         
    CPNE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPNE1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPNE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPNE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPNE1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPNE1 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CPNE1:
    hsa-miR-3163 hsa-miR-548t hsa-miR-548n hsa-miR-621 hsa-miR-335 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCPNE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPNE1
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPNE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for CPNE1 (Q998292, 3 ENSP000003172574) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3319746 I2D: score=1 STRING: ENSP00000309503
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    MYCBPQ994173, ENSP000003807024I2D: score=2 STRING: ENSP00000380702
    RDXP352413, ENSP000003428304I2D: score=2 STRING: ENSP00000342830
    UBE2MP610813, ENSP000002530234I2D: score=2 STRING: ENSP00000253023
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9430674
    GO:0016192vesicle-mediated transport TAS9430674

    CPNE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPNE1

    10/125 HMDB Compounds for CPNE1 (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----

    Search CenterWatch for drugs/clinical trials and news about CPNE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPNE1 gene (8 alternative transcripts): 
    NM_001198863.1  NM_003915.5  NM_152925.2  NM_152926.2  NM_152927.2  NM_152928.2  NM_152930.1  NM_152931.1  

    Unigene Cluster for CPNE1:

    Copine I
    Hs.246413  [show with all ESTs]
    Unigene Representative Sequence: NM_003915
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000352393(uc002xde.3) ENST00000462352 ENST00000473373 ENST00000498814
    ENST00000415920 ENST00000317677(uc010zvj.2) ENST00000483359 ENST00000397442
    ENST00000483495 ENST00000401607 ENST00000437340 ENST00000498056 ENST00000430570
    ENST00000412056 ENST00000486021 ENST00000414664 ENST00000416778 ENST00000439806

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CPNE1:
    hsa-miR-3163 hsa-miR-548t hsa-miR-548n hsa-miR-621 hsa-miR-335 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCPNE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPNE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPNE1
    Clone
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    OriGene clones in human, mouse for CPNE1 (see all 37)
    OriGene ORF clones in mouse, rat for CPNE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CPNE1 (NM_152928)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPNE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPNE1
    Sirion Biotech Customized lentivirus for stable overexpression of CPNE1 
                         Customized lentivirus expression plasmids for stable overexpression of CPNE1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPNE1
    OriGene qSTAR qPCR primer pairs in human, mouse for CPNE1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CPNE1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPNE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPNE1

    Additional mRNA sequence: 

    AB209827.1 AF314092.1 BC001142.1 BC021010.1 CR456790.1 NR_037188.1 U83246.1 

    24/37 DOTS entries (see all 37):

    DT.95314751  DT.87079377  DT.87012974  DT.100038785  DT.40116050  DT.452798  DT.100857615  DT.100672094 
    DT.100876345  DT.91900205  DT.95314752  DT.100672097  DT.120831449  DT.100850692  DT.100875912  DT.100672089 
    DT.95106804  DT.91832814  DT.100672085  DT.91986959  DT.120831334  DT.100672092  DT.100810200  DT.95314785 

    24/865 AceView cDNA sequences (see all 865):

    CK725112 CA434095 BU163174 AW470767 BQ064570 BE045345 BM784445 BE275212 
    AA310312 BG684697 BI335204 AW515172 BM927761 CB851070 AA352559 BM769655 
    BQ227391 BE265447 BM969171 BM511690 NM_152838 AA496832 BI091889 CR624522 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPNE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGCTGG
    CPNE1 Expression
    About this image


    See CPNE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPNE1

    SOURCE GeneReport for Unigene cluster: Hs.246413
        SABiosciences Custom PCR Arrays for CPNE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPNE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPNE1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpne11 , 5 copine I1, 5 86.5(n)1
    91.6(a)1
      2 (77.34 cM)5
    2666921  NM_170590.31  NP_733469.11 
     1560718455 
    chicken
    (Gallus gallus)
    Aves LOC1008582981 copine-1-like 70.59(n)
    74.38(a)
      100858298  XM_003642440.1  XP_003642488.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPNE16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    4(134350243-134371855)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688612 hypothetical protein MGC68861 78.45(n)    BC059291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpne11 copine I 66.16(n)
    66.92(a)
      324841  NM_199699.1  NP_955993.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.101272 Transcribed sequence with moderate similarity to protein more 69.91(n)  


    ENSEMBL Gene Tree for CPNE1 (if available)
    TreeFam Gene Tree for CPNE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPNE1 gene
    CPNE92  CPNE22  CPNE62  CPNE32  CPNE52  CPNE82  CPNE42  CPNE72  
    9 SIMAP similar genes for CPNE1 using alignment to 19 protein entries:     CPNE1_HUMAN (see all proteins):
    CPNE3    CPNE2    CPNE8    CPNE5    CPNE4    CPNE6
    CPNE7    CPNE9    DKFZp666C234

    CPNE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/554 SNPs in CPNE1 are shown (see all 554)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420036591,2
    --34213943(+) AAACAC/GACAAG 7 -- ds50010--------
    rs1175861911,2
    C,F--34214004(+) GTCAGG/AAGCAA 7 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.02EA 120
    rs1457550411,2
    --34214077(+) TAGCAC/TTGAGG 7 -- ut31 nc-transcript-variant0--------
    rs1809889121,2
    C--34214135(+) GGATTA/GAGGAC 7 -- ut31 nc-transcript-variant0--------
    rs115432391,2,4
    C,F,H--34214173(+) CCTGGG/AGGGCC 13 /P /L mis122Minor allele frequency- A:0.08NS EA NA WA CSA EU 8063
    rs1427701901,2
    C,F--34214218(+) TGAGCG/CGGGCC 13 /P /R mis11Minor allele frequency- C:0.00NA 4546
    rs1400900141,2
    F--34214250(+) GAGACC/AAGTTG 13 /L syn11Minor allele frequency- A:0.00NA 4548
    rs60605161,2
    C,F,A,H--34214368(+) CATGCT/CCAAGA 7 -- int122Minor allele frequency- C:0.26NS EA NA WA CSA 2346
    rs1850082141,2
    --34214503(+) CCGGCA/GGTAGG 13 R C mis10--------
    rs2003456711,2
    --34214529(+) TGTCGC/TGGGCA 13 H R mis10--------

    HapMap Linkage Disequilibrium report for CPNE1 (34213953 - 34252878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CPNE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660434CNV Deletion23128226
    nsv526188CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604205    OMIM disorders: --

    5 diseases for CPNE1:    About MalaCards
    sporadic breast cancer    glaucoma    infertility    breast cancer
    gastric cancer


    CPNE1 for disorders           About GeneDecksing


    Export disorders for CPNE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPNE1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CPNE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PubMed id 9430674)1, 2, 3, 9 Creutz C.E.... Cohen J. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach. (PubMed id 18523666)1, 9 Zhang Y....Ge J. (2008)
    5. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8904 HGNC: 2314 AceView: CPNE1 Ensembl:ENSG00000214078 euGenes: HUgn8904
    ECgene: CPNE1 H-InvDB: CPNE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPNE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPNE1 gene:
    Search GeneIP for patents involving CPNE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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