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Aliases for CPNE1 Gene

Aliases for CPNE1 Gene

  • Copine 1 2 3
  • Copine I 2 3 4 5
  • Chromobindin 17 3 4
  • CPN1 3 4
  • COPN1 3

External Ids for CPNE1 Gene

Previous GeneCards Identifiers for CPNE1 Gene

  • GC20M033972
  • GC20M033934
  • GC20M034883
  • GC20M034929
  • GC20M033677
  • GC20M034213
  • GC20M030991

Summaries for CPNE1 Gene

Entrez Gene Summary for CPNE1 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

GeneCards Summary for CPNE1 Gene

CPNE1 (Copine 1) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is CPNE6.

UniProtKB/Swiss-Prot for CPNE1 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).

Gene Wiki entry for CPNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE1 Gene

Genomics for CPNE1 Gene

Regulatory Elements for CPNE1 Gene

Promoters for CPNE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPNE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPNE1 Gene

Chromosome:
20
Start:
35,626,031 bp from pter
End:
35,664,956 bp from pter
Size:
38,926 bases
Orientation:
Minus strand

Genomic View for CPNE1 Gene

Genes around CPNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE1 Gene

Proteins for CPNE1 Gene

  • Protein details for CPNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99829-CPNE1_HUMAN
    Recommended name:
    Copine-1
    Protein Accession:
    Q99829
    Secondary Accessions:
    • E1P5Q4
    • Q6IBL3
    • Q9H243
    • Q9NTZ7

    Protein attributes for CPNE1 Gene

    Size:
    537 amino acids
    Molecular mass:
    59059 Da
    Quaternary structure:
    • Homodimer; homodimerizes via its C2 domains (PubMed:18212740). Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity (PubMed:18212740). Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O (PubMed:12522145).

neXtProt entry for CPNE1 Gene

Proteomics data for CPNE1 Gene at MOPED

Post-translational modifications for CPNE1 Gene

  • Ubiquitination at Lys 60, Lys 73, Lys 157, Lys 182, Lys 190, and Lys 522
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CPNE1 Gene

Domains & Families for CPNE1 Gene

Gene Families for CPNE1 Gene

Protein Domains for CPNE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99829

UniProtKB/Swiss-Prot:

CPNE1_HUMAN :
  • C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner (PubMed:25450385).
  • Belongs to the copine family.
Domain:
  • C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner (PubMed:25450385).
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE1: view

Function for CPNE1 Gene

Molecular function for CPNE1 Gene

GENATLAS Biochemistry:
copine 1,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in brain,fetal liver and heart
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the inflammatory cytokine TNF-alpha (PubMed:14674885). Up-regulated during neuronal progenitor cell differentiation (PubMed:23263657).

Gene Ontology (GO) - Molecular Function for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9430674
GO:0005515 protein binding IEA,IPI 12522145
genes like me logo Genes that share ontologies with CPNE1: view
genes like me logo Genes that share phenotypes with CPNE1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPNE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE1 Gene

Localization for CPNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE1 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269 PubMed:21087455, ECO:0000269 PubMed:25450385}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPNE1 Gene COMPARTMENTS Subcellular localization image for CPNE1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21087455
genes like me logo Genes that share ontologies with CPNE1: view

Pathways & Interactions for CPNE1 Gene

genes like me logo Genes that share pathways with CPNE1: view

Pathways by source for CPNE1 Gene

Gene Ontology (GO) - Biological Process for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IMP 18212740
GO:0010629 negative regulation of gene expression IMP 18212740
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP 14674885
GO:0043392 negative regulation of DNA binding IDA 18212740
genes like me logo Genes that share ontologies with CPNE1: view

No data available for SIGNOR curated interactions for CPNE1 Gene

Drugs & Compounds for CPNE1 Gene

(1) Drugs for CPNE1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(124) Additional Compounds for CPNE1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CPNE1: view

Transcripts for CPNE1 Gene

Unigene Clusters for CPNE1 Gene

Copine I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE1 Gene

No ASD Table

Relevant External Links for CPNE1 Gene

GeneLoc Exon Structure for
CPNE1
ECgene alternative splicing isoforms for
CPNE1

Expression for CPNE1 Gene

mRNA expression in normal human tissues for CPNE1 Gene

Protein differential expression in normal tissues from HIPED for CPNE1 Gene

This gene is overexpressed in Bone marrow stromal cell (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE1 Gene



SOURCE GeneReport for Unigene cluster for CPNE1 Gene Hs.246413

mRNA Expression by UniProt/SwissProt for CPNE1 Gene

Q99829-CPNE1_HUMAN
Tissue specificity: Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
genes like me logo Genes that share expression patterns with CPNE1: view

Protein tissue co-expression partners for CPNE1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CPNE1 Gene

Orthologs for CPNE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPNE1 35
  • 90.15 (n)
  • 94.59 (a)
CPNE1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE1 35
  • 90.8 (n)
  • 93.28 (a)
CPNE1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne1 35
  • 86.5 (n)
  • 91.6 (a)
Cpne1 16
Cpne1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpne1 35
  • 87.48 (n)
  • 92.15 (a)
oppossum
(Monodelphis domestica)
Mammalia CPNE1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CPNE1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858298 35
  • 70.52 (n)
  • 74.38 (a)
CPNE1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPNE1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne1 35
  • 68.69 (n)
  • 70.72 (a)
Str.3098 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68861 35
zebrafish
(Danio rerio)
Actinopterygii cpne1 35
  • 67.49 (n)
  • 68.44 (a)
cpne1 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T12A7.1 37
  • 39 (a)
Y73F8A.19 37
  • 24 (a)
soybean
(Glycine max)
eudicotyledons Gma.10127 35
rice
(Oryza sativa)
Liliopsida Os05g0373300 35
  • 51.37 (n)
  • 44.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
CSA.7161 36
  • 51 (a)
ManyToMany
Species with no ortholog for CPNE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE1 Gene

ENSEMBL:
Gene Tree for CPNE1 (if available)
TreeFam:
Gene Tree for CPNE1 (if available)

Paralogs for CPNE1 Gene

Paralogs for CPNE1 Gene

genes like me logo Genes that share paralogs with CPNE1: view

Variants for CPNE1 Gene

Sequence variations from dbSNP and Humsavar for CPNE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6579255 - 35,631,574(+) AGCAT(C/T)GCACC nc-transcript-variant, reference, missense
rs12481228 - 35,630,751(+) AGTCA(C/G)GGGGA nc-transcript-variant, reference, missense
rs11543239 - 35,626,251(+) CCTGG(A/G)GGGCC nc-transcript-variant, reference, missense
rs11815 -- 35,626,197(-) CCCAG(A/T)GGTCC nc-transcript-variant, utr-variant-3-prime
rs14836 -- 35,626,089(-) CCCAC(A/C)TTTGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPNE1 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680
esv2660434 CNV Deletion 23128226

Variation tolerance for CPNE1 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.70; 97.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE1 Gene

HapMap Linkage Disequilibrium report
CPNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE1 Gene

Disorders for CPNE1 Gene

Relevant External Links for CPNE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE1

No disorders were found for CPNE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE1 Gene

Publications for CPNE1 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach. (PMID: 18523666) Zhang Y. … Ge J. (Mol. Vis. 2008) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CPNE1 Gene

Sources for CPNE1 Gene

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