Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPNE1 Gene

Aliases for CPNE1 Gene

  • Copine I 2 3 4
  • CPN1 3 4 6
  • Copine-1 3
  • COPN1 3

External Ids for CPNE1 Gene

Previous GeneCards Identifiers for CPNE1 Gene

  • GC20M033972
  • GC20M033934
  • GC20M034883
  • GC20M034929
  • GC20M033677
  • GC20M034213
  • GC20M030991

Summaries for CPNE1 Gene

Entrez Gene Summary for CPNE1 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

GeneCards Summary for CPNE1 Gene

CPNE1 (Copine I) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Prostate Cancer. GO annotations related to this gene include transporter activity and phosphatidylserine binding. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE1 Gene

  • May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties

Gene Wiki entry for CPNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE1 Gene

Genomics for CPNE1 Gene

Regulatory Elements for CPNE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPNE1 Gene

35,626,031 bp from pter
35,664,956 bp from pter
38,926 bases
Minus strand

Genomic View for CPNE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE1 Gene

Proteins for CPNE1 Gene

  • Protein details for CPNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E1P5Q4
    • Q6IBL3
    • Q9H243
    • Q9NTZ7

    Protein attributes for CPNE1 Gene

    537 amino acids
    Molecular mass:
    59059 Da
    Quaternary structure:
    • Interacts with CCDC22.

neXtProt entry for CPNE1 Gene

Proteomics data for CPNE1 Gene at MOPED

Post-translational modifications for CPNE1 Gene

  • Ubiquitination at Lys60, Lys73, Lys135, Lys157, Lys182, Lys190, and Lys522
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CPNE1 Gene

Domains for CPNE1 Gene

Protein Domains for CPNE1 Gene


Suggested Antigen Peptide Sequences for CPNE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99829
  • Contains 2 C2 domains.
  • Contains 1 VWFA domain.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE1: view

No data available for Gene Families for CPNE1 Gene

Function for CPNE1 Gene

Molecular function for CPNE1 Gene

GENATLAS Biochemistry:
copine 1,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in brain,fetal liver and heart
UniProtKB/Swiss-Prot Function:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties

Gene Ontology (GO) - Molecular Function for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 9430674
GO:0005215 transporter activity TAS 9430674
GO:0005509 calcium ion binding IMP 25450385
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding TAS 9430674
genes like me logo Genes that share ontologies with CPNE1: view

Phenotypes for CPNE1 Gene

GenomeRNAi human phenotypes for CPNE1:
genes like me logo Genes that share phenotypes with CPNE1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPNE1 Gene

Localization for CPNE1 Gene

Subcellular locations from

Jensen Localization Image for CPNE1 Gene COMPARTMENTS Subcellular localization image for CPNE1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25450385
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 25450385
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CPNE1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE1 Gene

Pathways for CPNE1 Gene

genes like me logo Genes that share pathways with CPNE1: view

Pathways by source for CPNE1 Gene

2 BioSystems pathways for CPNE1 Gene

Gene Ontology (GO) - Biological Process for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9430674
GO:0006644 phospholipid metabolic process TAS --
GO:0016192 vesicle-mediated transport TAS 9430674
GO:0044281 small molecule metabolic process TAS --
GO:0045666 positive regulation of neuron differentiation IMP 25450385
genes like me logo Genes that share ontologies with CPNE1: view

Compounds for CPNE1 Gene

(125) HMDB Compounds for CPNE1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Phosphatidylserine(14:0/14:0)
Not Available
  • Phosphatidylserine(14:0/14:1n5)
Not Available
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
  • PS(14:0/16:1n7)
Not Available
genes like me logo Genes that share compounds with CPNE1: view

Transcripts for CPNE1 Gene

Unigene Clusters for CPNE1 Gene

Copine I:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPNE1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE1 Gene

No ASD Table

Relevant External Links for CPNE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE1 Gene

mRNA expression in normal human tissues for CPNE1 Gene

Protein differential expression in normal tissues for CPNE1 Gene

This gene is overexpressed in Bone marrow stromal cell (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPNE1 Gene

SOURCE GeneReport for Unigene cluster for CPNE1 Gene Hs.246413

genes like me logo Genes that share expressions with CPNE1: view

Expression partners for CPNE1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPNE1 Gene

Orthologs for CPNE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE1 35
  • 90.15 (n)
  • 94.59 (a)
CPNE1 36
  • 94 (a)
(Canis familiaris)
Mammalia CPNE1 35
  • 90.8 (n)
  • 93.28 (a)
CPNE1 36
  • 93 (a)
(Mus musculus)
Mammalia Cpne1 35
  • 86.5 (n)
  • 91.6 (a)
Cpne1 16
Cpne1 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Cpne1 35
  • 87.48 (n)
  • 92.15 (a)
(Monodelphis domestica)
Mammalia CPNE1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Pan troglodytes)
Mammalia CPNE1 36
  • 98 (a)
(Gallus gallus)
Aves LOC100858298 35
  • 70.52 (n)
  • 74.38 (a)
CPNE1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia CPNE1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne1 35
  • 68.69 (n)
  • 70.72 (a)
Str.3098 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68861 35
(Danio rerio)
Actinopterygii cpne1 35
  • 67.49 (n)
  • 68.44 (a)
cpne1 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea T12A7.1 37
  • 39 (a)
Y73F8A.19 37
  • 24 (a)
(Glycine max)
eudicotyledons Gma.10127 35
(Oryza sativa)
Liliopsida Os05g0373300 35
  • 51.37 (n)
  • 44.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
-- 36
  • 48 (a)
CSA.7161 36
  • 51 (a)
Species with no ortholog for CPNE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE1 Gene

Gene Tree for CPNE1 (if available)
Gene Tree for CPNE1 (if available)

Paralogs for CPNE1 Gene

Paralogs for CPNE1 Gene

genes like me logo Genes that share paralogs with CPNE1: view

Variants for CPNE1 Gene

Sequence variations from dbSNP and Humsavar for CPNE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11815 -- 35,626,197(-) CCCAG(A/T)GGTCC utr-variant-3-prime, nc-transcript-variant
rs14836 -- 35,626,089(-) CCCAC(A/C)TTTGC utr-variant-3-prime, nc-transcript-variant
rs926994 -- 35,633,101(+) TAGGT(A/G)AGCTC intron-variant
rs1118233 -- 35,640,427(+) AACCA(A/T)ATTAA intron-variant
rs2207889 -- 35,636,976(+) CCATA(A/C)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE1 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680
esv2660434 CNV Deletion 23128226

Relevant External Links for CPNE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE1 Gene

Disorders for CPNE1 Gene

No disorders were found for CPNE1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CPNE1 Gene

Publications for CPNE1 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3 4 23
  2. Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach. (PMID: 18523666) Zhang Y. … Ge J. (Mol. Vis. 2008) 3 23
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for CPNE1 Gene

Sources for CPNE1 Gene

Back to Top