Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPNE1 Gene

Aliases for CPNE1 Gene

  • Copine 1 2 3 5
  • Copine I 2 3 4
  • Chromobindin 17 3 4
  • CPN1 3 4
  • Copine-1 3
  • COPN1 3

External Ids for CPNE1 Gene

Previous GeneCards Identifiers for CPNE1 Gene

  • GC20M033972
  • GC20M033934
  • GC20M034883
  • GC20M034929
  • GC20M033677
  • GC20M034213
  • GC20M030991

Summaries for CPNE1 Gene

Entrez Gene Summary for CPNE1 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

GeneCards Summary for CPNE1 Gene

CPNE1 (Copine 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Glycerophospholipid biosynthesis. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is CPNE3.

UniProtKB/Swiss-Prot for CPNE1 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).

Gene Wiki entry for CPNE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE1 Gene

Genomics for CPNE1 Gene

Regulatory Elements for CPNE1 Gene

Enhancers for CPNE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G035739 3.1 FANTOM5 Ensembl ENCODE dbSUPER 87.4 -76.8 -76768 7.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CPNE1 RBM12 PHF20 RBM39 EIF6 AAR2 TRPC4AP RPL36P4 SPAG4 SCAND1
GH20G035765 1.8 FANTOM5 ENCODE dbSUPER 96.4 -104.6 -104590 9.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPL36P4 TGIF2 RBM39
GH20G035874 1.9 FANTOM5 Ensembl ENCODE dbSUPER 70.1 -210.6 -210562 2.6 PKNOX1 FOXA2 ATF1 ARNT SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 KLF7 CPNE1 RBM12 RPL36P4 TRPC4AP NFS1 EIF6 RBM39 AAR2 PHF20 ROMO1
GH20G035881 1.9 FANTOM5 Ensembl ENCODE dbSUPER 70.1 -218.8 -218830 4.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF143 FOS DEK CPNE1 RBM12 RPL36P4 TRPC4AP EIF6 AAR2 RNU6-937P PHF20 RBM39 NFS1
GH20G035659 1.4 ENCODE dbSUPER 87.7 +2.1 2124 5.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC CPNE1 RBM12 NCOA6 EIF6 NFS1 ROMO1 TRPC4AP PHF20 AAR2 RPL36P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPNE1 on UCSC Golden Path with GeneCards custom track

Promoters for CPNE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136587 956 2801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC

Genomic Location for CPNE1 Gene

Chromosome:
20
Start:
35,626,031 bp from pter
End:
35,664,956 bp from pter
Size:
38,926 bases
Orientation:
Minus strand

Genomic View for CPNE1 Gene

Genes around CPNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE1 Gene

Proteins for CPNE1 Gene

  • Protein details for CPNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99829-CPNE1_HUMAN
    Recommended name:
    Copine-1
    Protein Accession:
    Q99829
    Secondary Accessions:
    • E1P5Q4
    • Q6IBL3
    • Q9H243
    • Q9NTZ7

    Protein attributes for CPNE1 Gene

    Size:
    537 amino acids
    Molecular mass:
    59059 Da
    Quaternary structure:
    • Homodimer; homodimerizes via its C2 domains (PubMed:18212740). Interacts with p65/RELA (via N-terminus); this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity (PubMed:18212740). Interacts (via VWFA domain) with ACTB, CCDC22, MYCBP2, PPP5C, RDX and UBE2O (PubMed:12522145).

neXtProt entry for CPNE1 Gene

Post-translational modifications for CPNE1 Gene

  • Ubiquitination at Lys60, isoforms=73, isoforms=157, isoforms=182, isoforms=190, and Lys522
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CPNE1 Gene

Domains & Families for CPNE1 Gene

Gene Families for CPNE1 Gene

Protein Domains for CPNE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99829

UniProtKB/Swiss-Prot:

CPNE1_HUMAN :
  • C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner (PubMed:25450385).
  • Belongs to the copine family.
Domain:
  • C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner (PubMed:25450385).
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE1: view

Function for CPNE1 Gene

Molecular function for CPNE1 Gene

GENATLAS Biochemistry:
copine 1,calcium-dependent,phospholipid binding protein,potentially involved in regulating membrane trafficking,expressed in brain,fetal liver and heart
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the inflammatory cytokine TNF-alpha (PubMed:14674885). Up-regulated during neuronal progenitor cell differentiation (PubMed:23263657).

Gene Ontology (GO) - Molecular Function for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 9430674
GO:0004175 endopeptidase activity IDA 18212740
GO:0005215 transporter activity TAS 9430674
GO:0005509 calcium ion binding IMP 25450385
GO:0005515 protein binding IPI 12522145
genes like me logo Genes that share ontologies with CPNE1: view
genes like me logo Genes that share phenotypes with CPNE1: view

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE1 Gene

Localization for CPNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE1 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269 PubMed:21087455, ECO:0000269 PubMed:25450385}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPNE1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
lysosome 4

Gene Ontology (GO) - Cellular Components for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18212740
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 21087455
GO:0005829 cytosol IDA 12949241
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CPNE1: view

Pathways & Interactions for CPNE1 Gene

genes like me logo Genes that share pathways with CPNE1: view

Pathways by source for CPNE1 Gene

Gene Ontology (GO) - Biological Process for CPNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IMP 18212740
GO:0006629 lipid metabolic process TAS 9430674
GO:0010629 negative regulation of gene expression IMP 18212740
genes like me logo Genes that share ontologies with CPNE1: view

No data available for SIGNOR curated interactions for CPNE1 Gene

Drugs & Compounds for CPNE1 Gene

(1) Drugs for CPNE1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(124) Additional Compounds for CPNE1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with CPNE1: view

Transcripts for CPNE1 Gene

Unigene Clusters for CPNE1 Gene

Copine I:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE1 Gene

No ASD Table

Relevant External Links for CPNE1 Gene

GeneLoc Exon Structure for
CPNE1
ECgene alternative splicing isoforms for
CPNE1

Expression for CPNE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPNE1 Gene

Protein differential expression in normal tissues from HIPED for CPNE1 Gene

This gene is overexpressed in Bone marrow stromal cell (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPNE1 Gene



Protein tissue co-expression partners for CPNE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPNE1 Gene:

CPNE1

SOURCE GeneReport for Unigene cluster for CPNE1 Gene:

Hs.246413

mRNA Expression by UniProt/SwissProt for CPNE1 Gene:

Q99829-CPNE1_HUMAN
Tissue specificity: Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).

Evidence on tissue expression from TISSUES for CPNE1 Gene

  • Nervous system(4.9)
  • Lung(3.7)
  • Skin(3.4)
  • Intestine(3.1)
  • Pancreas(3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CPNE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE1 Gene

Orthologs for CPNE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE1 34 35
  • 90.8 (n)
cow
(Bos Taurus)
Mammalia CPNE1 34 35
  • 90.15 (n)
rat
(Rattus norvegicus)
Mammalia Cpne1 34
  • 87.48 (n)
mouse
(Mus musculus)
Mammalia Cpne1 34 16 35
  • 86.5 (n)
oppossum
(Monodelphis domestica)
Mammalia CPNE1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CPNE1 35
  • 73 (a)
OneToOne
LOC100858298 34
  • 70.52 (n)
lizard
(Anolis carolinensis)
Reptilia CPNE1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne1 34
  • 68.69 (n)
Str.3098 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68861 34
zebrafish
(Danio rerio)
Actinopterygii cpne1 34 35
  • 67.49 (n)
worm
(Caenorhabditis elegans)
Secernentea T12A7.1 36
  • 39 (a)
Y73F8A.19 36
  • 24 (a)
soybean
(Glycine max)
eudicotyledons Gma.10127 34
rice
(Oryza sativa)
Liliopsida Os05g0373300 34
  • 51.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7161 35
  • 51 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
Species where no ortholog for CPNE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE1 Gene

ENSEMBL:
Gene Tree for CPNE1 (if available)
TreeFam:
Gene Tree for CPNE1 (if available)

Paralogs for CPNE1 Gene

Variants for CPNE1 Gene

Sequence variations from dbSNP and Humsavar for CPNE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000003448 -- 35,661,115(+) TACCC(A/C)CCCCA intron-variant
rs1000250538 -- 35,646,283(+) AGAAA(A/C)AAAAA intron-variant
rs1000337280 -- 35,641,368(+) GTTGC(A/T)ATCTG intron-variant
rs1000535882 -- 35,641,586(+) TAATG(C/T)ATGCA intron-variant
rs1000539674 -- 35,660,860(+) GTCTA(C/T)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE1 Gene

Variant ID Type Subtype PubMed ID
esv2660434 CNV deletion 23128226
esv3645717 CNV gain 21293372
nsv526188 CNV gain 19592680

Variation tolerance for CPNE1 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.70; 97.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPNE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE1 Gene

Disorders for CPNE1 Gene

Relevant External Links for CPNE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPNE1

No disorders were found for CPNE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE1 Gene

Publications for CPNE1 Gene

  1. The copines, a novel class of C2 domain-containing, calcium- dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz C.E. … Cohen J. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells. (PMID: 25450385) Park N. … Park J.Y. (Biochem. Biophys. Res. Commun. 2014) 3 4 64
  3. Copine1 enhances neuronal differentiation of the hippocampal progenitor HiB5 cells. (PMID: 23263657) Park N. … Park J.Y. (Mol. Cells 2012) 3 4 64
  4. Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. (PMID: 21087455) Perestenko P.V. … Jeffrey McIlhinney R.A. (FEBS J. 2010) 3 4 64
  5. Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach. (PMID: 18523666) Zhang Y. … Ge J. (Mol. Vis. 2008) 3 22 64

Products for CPNE1 Gene

Sources for CPNE1 Gene

Content
Loading form....