Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPN2 Gene

Aliases for CPN2 Gene

  • Carboxypeptidase N Subunit 2 2 3 5
  • Carboxypeptidase N, Polypeptide 2, 83kD 2 3
  • Carboxypeptidase N Regulatory Subunit 3 4
  • Carboxypeptidase N, Polypeptide 2 2 3
  • Carboxypeptidase N Large Subunit 3 4
  • Carboxypeptidase N 83 KDa Chain 3 4
  • ACBP 3 4
  • Carboxypeptidase N Polypeptide 2 4
  • Arginine Carboxypeptidase 3

External Ids for CPN2 Gene

Previous HGNC Symbols for CPN2 Gene

  • ACBP

Previous GeneCards Identifiers for CPN2 Gene

  • GC08U990012
  • GC03M195380
  • GC03M195542
  • GC03U900610
  • GC03M194060
  • GC03M191440

Summaries for CPN2 Gene

GeneCards Summary for CPN2 Gene

CPN2 (Carboxypeptidase N Subunit 2) is a Protein Coding gene. GO annotations related to this gene include enzyme regulator activity. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for CPN2 Gene

  • The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

Gene Wiki entry for CPN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPN2 Gene

Genomics for CPN2 Gene

Regulatory Elements for CPN2 Gene

Enhancers for CPN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPN2 on UCSC Golden Path with GeneCards custom track

Promoters for CPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPN2 Gene

Chromosome:
3
Start:
194,339,765 bp from pter
End:
194,351,345 bp from pter
Size:
11,581 bases
Orientation:
Minus strand

Genomic View for CPN2 Gene

Genes around CPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPN2 Gene

Proteins for CPN2 Gene

  • Protein details for CPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22792-CPN2_HUMAN
    Recommended name:
    Carboxypeptidase N subunit 2
    Protein Accession:
    P22792
    Secondary Accessions:
    • B2RPE7
    • Q86SU4
    • Q8N5V4

    Protein attributes for CPN2 Gene

    Size:
    545 amino acids
    Molecular mass:
    60557 Da
    Quaternary structure:
    • Tetramer of two catalytic chains and two glycosylated inactive chains.

neXtProt entry for CPN2 Gene

Proteomics data for CPN2 Gene at MOPED

Post-translational modifications for CPN2 Gene

  • Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.
  • Glycosylation at Asn 74, Asn 111, Asn 119, Asn 228, Asn 266, Asn 348, Asn 359, and Asn 518
  • Modification sites at PhosphoSitePlus

Other Protein References for CPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CPN2 Gene

Domains & Families for CPN2 Gene

Gene Families for CPN2 Gene

Suggested Antigen Peptide Sequences for CPN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22792

UniProtKB/Swiss-Prot:

CPN2_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 12 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CPN2: view

Function for CPN2 Gene

Molecular function for CPN2 Gene

GENATLAS Biochemistry:
carboxypeptidase N2 regulatory subunit,83kDa
UniProtKB/Swiss-Prot Function:
The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.
genes like me logo Genes that share phenotypes with CPN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPN2

miRNA for CPN2 Gene

miRTarBase miRNAs that target CPN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPN2 Gene

Localization for CPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPN2 Gene COMPARTMENTS Subcellular localization image for CPN2 gene
Compartment Confidence
extracellular 5
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CPN2 Gene

Pathways & Interactions for CPN2 Gene

SuperPathways for CPN2 Gene

No Data Available

Interacting Proteins for CPN2 Gene

Gene Ontology (GO) - Biological Process for CPN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPN2 Gene

Drugs & Compounds for CPN2 Gene

(1) Drugs for CPN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with CPN2: view

Transcripts for CPN2 Gene

mRNA/cDNA for CPN2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPN2 Gene

Carboxypeptidase N, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPN2 Gene

No ASD Table

Relevant External Links for CPN2 Gene

GeneLoc Exon Structure for
CPN2
ECgene alternative splicing isoforms for
CPN2

Expression for CPN2 Gene

mRNA expression in normal human tissues for CPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPN2 Gene

This gene is overexpressed in Liver (x45.2) and Kidney - Cortex (x6.1).

Protein differential expression in normal tissues from HIPED for CPN2 Gene

This gene is overexpressed in Serum (33.6), Plasma (11.5), Synovial fluid (8.8), and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPN2 Gene



SOURCE GeneReport for Unigene cluster for CPN2 Gene Hs.528368

genes like me logo Genes that share expression patterns with CPN2: view

Protein tissue co-expression partners for CPN2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPN2 Gene

Orthologs for CPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPN2 35
  • 81.47 (n)
  • 76.51 (a)
CPN2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPN2 35
  • 81.19 (n)
  • 75.92 (a)
CPN2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpn2 35
  • 75.96 (n)
  • 67.71 (a)
Cpn2 16
Cpn2 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPN2 35
  • 98.47 (n)
  • 98.72 (a)
CPN2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpn2 35
  • 77.35 (n)
  • 68.52 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CPN2 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPN2 35
  • 57.82 (n)
  • 44.31 (a)
CPN2 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPN2 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734844 35
  • 45.59 (n)
  • 36.98 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153913 35
  • 48.72 (n)
  • 33.71 (a)
CPN2 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16974 36
  • 12 (a)
OneToMany
Species with no ortholog for CPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPN2 Gene

ENSEMBL:
Gene Tree for CPN2 (if available)
TreeFam:
Gene Tree for CPN2 (if available)

Paralogs for CPN2 Gene

(5) SIMAP similar genes for CPN2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CPN2 Gene

genes like me logo Genes that share paralogs with CPN2: view

Variants for CPN2 Gene

Sequence variations from dbSNP and Humsavar for CPN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11711157 - 194,341,097(+) AGACA(C/T)GGTGA reference, missense
rs3732477 - 194,341,790(-) CTGTC(A/G)CTGAG reference, missense
rs4974538 - 194,341,177(+) CCTGC(C/T)AAGGA reference, missense
rs9998 -- 194,339,977(-) agcac(C/T)caccc downstream-variant-500B, utr-variant-3-prime
rs10284 -- 194,340,358(-) cataa(C/T)attac utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPN2 Gene

Variant ID Type Subtype PubMed ID
esv24336 CNV Gain 19812545
esv2563733 CNV Insertion 19546169
esv2726431 CNV Deletion 23290073

Variation tolerance for CPN2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPN2 Gene

Disorders for CPN2 Gene

Relevant External Links for CPN2

Human Genome Epidemiology (HuGE) Navigator
CPN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPN2

No disorders were found for CPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPN2 Gene

Publications for CPN2 Gene

  1. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. (PMID: 2378615) Tan F. … Erdoes E.G. (J. Biol. Chem. 1990) 2 3 4 67
  2. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley D.A. … Skidgel R.A. (Genomics 1998) 2 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3

Products for CPN2 Gene

Sources for CPN2 Gene

Content