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Aliases for CPN2 Gene

Aliases for CPN2 Gene

  • Carboxypeptidase N, Polypeptide 2 2 3
  • Carboxypeptidase N, Polypeptide 2, 83kD 2 3
  • Carboxypeptidase N Regulatory Subunit 3 4
  • Carboxypeptidase N Large Subunit 3 4
  • Carboxypeptidase N 83 KDa Chain 3 4
  • ACBP 3 4
  • Carboxypeptidase N Polypeptide 2 4
  • Carboxypeptidase N Subunit 2 3
  • Arginine Carboxypeptidase 3

External Ids for CPN2 Gene

Previous Symbols for CPN2 Gene

  • ACBP

Summaries for CPN2 Gene

GeneCards Summary for CPN2 Gene

CPN2 (Carboxypeptidase N, Polypeptide 2) is a Protein Coding gene. GO annotations related to this gene include enzyme regulator activity. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for CPN2 Gene

  • The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit

Gene Wiki entry for CPN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPN2 Gene

Genomics for CPN2 Gene

Genomic Location for CPN2 Gene

Start:
194,339,765 bp from pter
End:
194,351,335 bp from pter
Size:
11,571 bases
Orientation:
Minus strand

Genomic View for CPN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPN2 Gene

Regulatory Elements for CPN2 Gene

Proteins for CPN2 Gene

  • Protein details for CPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22792-CPN2_HUMAN
    Recommended name:
    Carboxypeptidase N subunit 2
    Protein Accession:
    P22792
    Secondary Accessions:
    • B2RPE7
    • Q86SU4
    • Q8N5V4

    Protein attributes for CPN2 Gene

    Size:
    545 amino acids
    Molecular mass:
    60557 Da
    Quaternary structure:
    • Tetramer of two catalytic chains and two glycosylated inactive chains

neXtProt entry for CPN2 Gene

Proteomics data for CPN2 Gene at MOPED

Post-translational modifications for CPN2 Gene

  • Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit
  • Glycosylation at Asn74, Asn111, Asn119, Asn228, Asn266, Asn348, Asn359, and Asn518

Other Protein References for CPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPN2 Gene

Domains for CPN2 Gene

Gene Families for CPN2 Gene

UniProtKB/Swiss-Prot:

CPN2_HUMAN
Domain:
  • Contains 1 LRRCT domain.:
    • P22792
  • Contains 1 LRRNT domain.:
    • P22792
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.:
    • P22792
genes like me logo Genes that share domains with CPN2: view

Function for CPN2 Gene

Molecular function for CPN2 Gene

GENATLAS Biochemistry: carboxypeptidase N2 regulatory subunit,83kDa
UniProtKB/Swiss-Prot Function: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit

Gene Ontology (GO) - Molecular Function for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030234 enzyme regulator activity NAS 2378615
genes like me logo Genes that share ontologies with CPN2: view

miRNA for CPN2 Gene

miRTarBase miRNAs that target CPN2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPN2 Gene

Localization for CPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPN2 Gene COMPARTMENTS Subcellular localization image for CPN2 gene
Compartment Confidence
extracellular 5
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 2378615
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with CPN2: view

Pathways for CPN2 Gene

SuperPathways for CPN2 Gene

No Data Available

Interacting Proteins for CPN2 Gene

Gene Ontology (GO) - Biological Process for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050790 regulation of catalytic activity NAS 2378615
GO:0050821 protein stabilization NAS 2378615
genes like me logo Genes that share ontologies with CPN2: view

No data available for Pathways by source for CPN2 Gene

Compounds for CPN2 Gene

(1) HMDB Compounds for CPN2 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with CPN2: view

Transcripts for CPN2 Gene

mRNA/cDNA for CPN2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPN2 Gene

Carboxypeptidase N, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPN2 Gene

No ASD Table

Relevant External Links for CPN2 Gene

GeneLoc Exon Structure for
CPN2
ECgene alternative splicing isoforms for
CPN2

Expression for CPN2 Gene

mRNA expression in normal human tissues for CPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPN2 Gene

This gene is overexpressed in Liver (45.2) and Kidney - Cortex (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPN2 Gene

SOURCE GeneReport for Unigene cluster for CPN2 Gene Hs.528368

genes like me logo Genes that share expressions with CPN2: view

Orthologs for CPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPN2 36
  • 98.47 (n)
  • 98.72 (a)
CPN2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPN2 36
  • 81.47 (n)
  • 76.51 (a)
CPN2 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPN2 36
  • 81.19 (n)
  • 75.92 (a)
CPN2 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpn2 36
  • 75.96 (n)
  • 67.71 (a)
Cpn2 16
Cpn2 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPN2 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpn2 36
  • 77.35 (n)
  • 68.52 (a)
chicken
(Gallus gallus)
Aves CPN2 36
  • 57.82 (n)
  • 44.31 (a)
CPN2 37
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPN2 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734844 36
  • 45.59 (n)
  • 36.98 (a)
zebrafish
(Danio rerio)
Actinopterygii CPN2 37
  • 30 (a)
OneToOne
zgc:153913 36
  • 48.72 (n)
  • 33.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16974 37
  • 12 (a)
OneToMany
Species with no ortholog for CPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPN2 Gene

ENSEMBL:
Gene Tree for CPN2 (if available)
TreeFam:
Gene Tree for CPN2 (if available)

Paralogs for CPN2 Gene

Selected SIMAP similar genes for CPN2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CPN2 Gene

genes like me logo Genes that share paralogs with CPN2: view

Variants for CPN2 Gene

Sequence variations from dbSNP and Humsavar for CPN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9998 -- 194,339,977(-) agcac(C/T)caccc utr-variant-3-prime, downstream-variant-500B
rs10284 -- 194,340,358(-) cataa(C/T)attac utr-variant-3-prime, downstream-variant-500B
rs12940 -- 194,340,087(-) TCCAC(A/G)ATCCT utr-variant-3-prime, downstream-variant-500B
rs1048996 -- 194,340,314(-) ATTTC(C/G/T)TTGCC utr-variant-3-prime, downstream-variant-500B
rs1049000 -- 194,340,312(-) TTCTT(G/T)GCCCT utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CPN2 Gene

Variant ID Type Subtype PubMed ID
esv24336 CNV Gain 19812545
esv2563733 CNV Insertion 19546169
esv2726431 CNV Deletion 23290073

Relevant External Links for CPN2 Gene

HapMap Linkage Disequilibrium report
CPN2

Disorders for CPN2 Gene

Relevant External Links for CPN2

Human Genome Epidemiology (HuGE) Navigator
CPN2
genes like me logo Genes that share disorders with CPN2: view

No data available for UniProtKB/Swiss-Prot for CPN2 Gene

Publications for CPN2 Gene

  1. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. (PMID: 2378615) Tan F. … Erdoes E.G. (J. Biol. Chem. 1990) 2 3 4
  2. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PMID: 3408501) Skidgel R.A. … Erdoes E.G. (Biochem. Biophys. Res. Commun. 1988) 3 4
  3. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley D.A. … Skidgel R.A. (Genomics 1998) 2 3
  4. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PMID: 14760718) Bunkenborg J. … Wisniewski J.R. (Proteomics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPN2 Gene

Sources for CPN2 Gene

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