CPN2 Gene
protein-coding GIFtS : 49
GCID: GC03 M194060
carboxypeptidase N, polypeptide 2 (Previous names: carboxypeptidase N, polypeptide 2, 83kD ) (Previous symbol: ACBP )
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Aliasesfor CPN2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Carboxypeptidase N, Polypeptide 2 1 2 Carboxypeptidase N Regulatory Subunit2 3 ACBP1 2 3 Arginine Carboxypeptidase (Carboxypeptidase N)2 Carboxypeptidase N, Polypeptide 2, 83kD1 2 Carboxypeptidase N Subunit 22 Carboxypeptidase N 83 KDa Chain2 3 Carboxypeptidase N Polypeptide 23 Carboxypeptidase N Large Subunit2 3
Export aliases for CPN2 gene to outside databases Previous GC identifers: GC08U990012 GC03M195380 GC03M195542 GC03U900610 GC03M191440
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Summariesfor CPN2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792 Function : The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it incirculation. Under some circumstances it may be an allosteric modifier of the catalytic subunit Gene Wiki entry for CPN2
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Genomic Viewsfor CPN2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_029928.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPN2 gene promoter: GR PPAR-gamma1 GR-beta Hand1 PPAR-gamma2 GR-alpha NF-kappaB1 E47 Other transcription factors Search SABiosciences Chromatin IP Primers for CPN2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPN2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29 CPN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M194060: view genomic region
(about GC identifiers )
Start:
194,060,494 bp from pter
End:
194,072,057 bp from pter
Size:
11,564 bases
Orientation:
minus strand
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Proteinsfor CPN2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792 (See
protein sequence )Recommended Name: Carboxypeptidase N subunit 2 precursor Size : 545 amino acids; 60557 Da
Subunit : Tetramer of two catalytic chains and two glycosylated inactive chains
Subcellular location : Secreted
Secondary accessions : B2RPE7 Q86SU4 Q8N5V4Explore the universe of human proteins at neXtProt for CPN2: NX_P22792 Post-translational modifications:
Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P22792 CPN2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001073982.2 ENSEMBL proteins: ENSP00000319464 ENSP00000402232 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
CPN2 for ontologies About GeneDecksing CPN2 Antibody Products: Assay Products for CPN2:
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Protein
Domains / Familiesfor CPN2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CPN2 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P22792 ProtoNet protein and cluster: P22792
2 Blocks protein families : IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792 Similarity : Contains 12 LRR (leucine-rich) repeatsSimilarity : Contains 1 LRRCT domainSimilarity : Contains 1 LRRNT domain
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Functionfor CPN2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792 Function : The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it incirculation. Under some circumstances it may be an allosteric modifier of the catalytic subunit
Genatlas biochemistry entry for CPN2 : carboxypeptidase N2 regulatory subunit,83kDa Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPN2 (NM_001080513 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPN2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPN2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030234 enzyme regulator activity
NAS 2378615
CPN2 for ontologies About GeneDecksing Animal Models: Mouse knock-out Cpn2 tm1Lex for CPN2 1 MGI phenotypic allele for Cpn2 (no phenotypes)
CPN2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor CPN2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPN2 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for CPN2 (ENSP00000319464 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
CPN2 for ontologies About GeneDecksing
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Drugs & Compoundsfor CPN2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CPN2 1 HMDB Compound for CPN2 About this table Search CenterWatch for drugs/clinical trials and news about CPN2
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Transcriptsfor CPN2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CPN2 gene: NM_001080513.2 Unigene Cluster for CPN2:
Carboxypeptidase N, polypeptide 2 Hs.528368 [show with all ESTs ] Unigene Representative Sequence: NM_001080513 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000323830 (uc003fts.3 ) ENST00000429275 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CPN2 (NM_001080513 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPN2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPN2
Additional cDNA sequence: BC031569.1 BC042334.1 BC137398.1 BC137403.1 J05158.2
1 DOTS entry : DT.412177
GeneLoc Exon Structure
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Expression for CPN2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CPN2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCACTCATA
About this image CPN2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Adipose Interscapular Brown Adipose Depot Adipose Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CPN2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CPN2 SOURCE GeneReport for Unigene cluster: Hs.528368 SABiosciences Custom PCR Arrays for CPN2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPN2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CPN2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPN2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPN2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN2
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Orthologsfor CPN2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CPN2 gene from 5/17 species (see all 17 ) About this table
ENSEMBL Gene Tree for CPN2 (if available)TreeFam Gene Tree for CPN2 (if available)
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Paralogsfor CPN2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CPN2 gene FLRT1 2 GP5 2 LRRC15 2 LRRTM3 2 IGFALS 2 LRIG1 2 FLRT2 2 LRRTM2 2 LRRTM1 2 LRIG3 2 LRRTM4 2 CHAD 2 FLRT3 2 LRIG2 2 CHADL 2 VASN 2 5 SIMAP similar genes for CPN2 using alignment to 1 protein entry: CPN2_HUMAN :ISLR LGR6 LRIG3 HMFT1766 LRG1
CPN2 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for CPN2 PGOHUM00000232632
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Genomic Variantsfor CPN2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CPN2 (194060494 - 194072057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CPN2 2 Indels : 98579 68531
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPN2
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Disorders
/ Diseasesfor CPN2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CPN2 for disorders About MalaCards
CPN2 for disorders About GeneDecksing
OMIM gene information: 603104
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: CPN2 (185 documents) Export disorders for CPN2 gene to outside databases
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Publicationsfor CPN2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CPN2 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with CPN2) Utopia : connect your pdf to the dynamic world of online information
The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. (PubMed id 2378615) 1 , 2 , 3 Tan F.... Erdoes E.G. (1990) Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952) 1 , 2 Liu T.... Smith R.D. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718) 1 , 2 Bunkenborg J.... Wisniewski J.R. (2004) Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828) 1 , 3 Riley D.A....Skidgel R.A. (1998) Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PubMed id 3408501) 1 , 2 Skidgel R.A....Erdoes E.G. (1988) Identification of genetic factors associated with sus ceptibility to angiotensin-converting enzyme inhibitors-induced cough. (PubMed id 21052031) 1 Grilo A....SA!ez M.E. (2011) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 2 Muzny D.M....Gibbs R.A. (2006)
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External Searches for CPN2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CPN2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CPN2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CPN2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CPN2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CPN2 gene: Search GeneIP for patents involving CPN2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CPN2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CPN2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CPN2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CPN2 OriGene Protein Over-expression Lysate for CPN2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CPN2 OriGene 3'-UTR Clone for CPN2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CPN2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CPN2 OriGene Custom Protein Services for CPN2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPN2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CPN2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPN2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CPN2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CPN2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CPN2
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CPN2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN2
ThermoFisher Antibodies for CPN2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CPN2
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Aliases for CPN2
Databases for CPN2
Disorders / Diseases for CPN2
Domains / Families for CPN2
Drugs / Compounds for CPN2
Expression for CPN2
Function for CPN2
Genomic Views for CPN2
Intellectual Property for CPN2
Orthologs for CPN2
Paralogs for CPN2
Pathways / Interactions for CPN2
Products for CPN2
Proteins for CPN2
Publications for CPN2
Search Box for CPN2
Summaries for CPN2
Transcripts for CPN2
Variants for CPN2
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