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CPN2 Gene

protein-coding   GIFtS: 51
GCID: GC03M194060

Carboxypeptidase N, Polypeptide 2

(Previous names: carboxypeptidase N, polypeptide 2, 83kD)
(Previous symbol: ACBP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase N, Polypeptide 21 2     Carboxypeptidase N Regulatory Subunit2 3
ACBP1 2 3     Arginine Carboxypeptidase (Carboxypeptidase N)2
Carboxypeptidase N, Polypeptide 2, 83kD1 2     Carboxypeptidase N Subunit 22
Carboxypeptidase N 83 KDa Chain2 3     Carboxypeptidase N Polypeptide 23
Carboxypeptidase N Large Subunit2 3     

External Ids:    HGNC: 23131   Entrez Gene: 13702   Ensembl: ENSG000001787727   OMIM: 6031045   UniProtKB: P227923   

Export aliases for CPN2 gene to outside databases

Previous GC identifers: GC08U990012 GC03M195380 GC03M195542 GC03U900610 GC03M191440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CPN2 Gene:
CPN2 (carboxypeptidase N, polypeptide 2) is a protein-coding gene. Diseases associated with CPN2 include corticosterone methyloxidase type ii deficiency, and glucocorticoid-remediable aldosteronism. GO annotations related to this gene include enzyme regulator activity. An important paralog of this gene is GP5.

UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792
Function: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in
circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit

Gene Wiki entry for CPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPN2 gene promoter:
         GR   PPAR-gamma1   GR-beta   Hand1   PPAR-gamma2   GR-alpha   NF-kappaB1   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CPN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

CPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M194060:  view genomic region     (about GC identifiers)

Start:
194,060,494 bp from pter      End:
194,072,057 bp from pter
Size:
11,564 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792 (See protein sequence)
Recommended Name: Carboxypeptidase N subunit 2 precursor  
Size: 545 amino acids; 60557 Da
Subunit: Tetramer of two catalytic chains and two glycosylated inactive chains
Secondary accessions: B2RPE7 Q86SU4 Q8N5V4

Explore the universe of human proteins at neXtProt for CPN2: NX_P22792

Explore proteomics data for CPN2 at MOPED

Post-translational modifications: 

  • Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain
    disulfide bonds with the 50 kDa catalytic subunit1
  • Glycosylation2 at Asn74, Asn111, Asn119, Asn228, Asn266, Asn348, Asn359, Asn518

  • See CPN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073982.2  
    ENSEMBL proteins: 
     ENSP00000319464   ENSP00000402232  

    CPN2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CPN2
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    Cloud-Clone Corp. Proteins for CPN2

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    Cloud-Clone Corp. CLIAs for CPN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase N, polypeptide 2
    Metallocarboxypeptidases

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P22792

    ProtoNet protein and cluster: P22792

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: CPN2_HUMAN, P22792
    Similarity: Contains 12 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    CPN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPN2_HUMAN, P22792
    Function: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in
    circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit

         Genatlas biochemistry entry for CPN2:
    carboxypeptidase N2 regulatory subunit,83kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030234enzyme regulator activity NAS2378615
         
    CPN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cpn2 (no phenotypes)

    CPN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cpn2tm1Lex for CPN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPN2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPN2

    miRNA
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    miRTarBase miRNAs that target CPN2:
    hsa-mir-26b-5p (MIRT029261)

    Block miRNA regulation of human, mouse, rat CPN2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CPN2:
    hsa-miR-515-5p hsa-miR-766 hsa-miR-450b-5p hsa-miR-519e*
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    Predesigned siRNA for gene silencing in human, mouse, rat CPN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPN2_HUMAN, P22792: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS2378615
    GO:0072562blood microparticle IDA--

    CPN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPN2
    Interactions:

        Search GeneGlobe Interaction Network for CPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CPN2 (ENSP000003194644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPN1ENSP000003594464STRING: ENSP00000359446
    IKBKGENSP000003586224STRING: ENSP00000358622
    PPRC1ENSP000002780704STRING: ENSP00000278070
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050790regulation of catalytic activity NAS2378615
    GO:0050821protein stabilization NAS2378615

    CPN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPN2

    1 HMDB Compound for CPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPN2 gene: 
    NM_001080513.2  

    Unigene Cluster for CPN2:

    Carboxypeptidase N, polypeptide 2
    Hs.528368  [show with all ESTs]
    Unigene Representative Sequence: NM_001080513
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323830(uc003fts.3) ENST00000429275
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CPN2:
    hsa-miR-515-5p hsa-miR-766 hsa-miR-450b-5p hsa-miR-519e*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CPN2 (NM_001080513)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPN2
      QuantiTect SYBR Green Assays in human, mouse, rat CPN2
      QuantiFast Probe-based Assays in human, mouse, rat CPN2

    Additional mRNA sequence: 

    BC031569.1 BC042334.1 BC137398.1 BC137403.1 J05158.2 

    1 DOTS entry:

    DT.412177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACTCATA
    CPN2 Expression
    About this image


    CPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Eye (Sensory Organs)
             Retina
     
     Liver (Hepatobiliary System)
    CPN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528368
        Custom PCR Arrays for CPN2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPN2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpn21 , 5 carboxypeptidase N, polypeptide 21, 5 75.96(n)1
    67.71(a)1
      16 (21.22 cM)5
    717561  NM_027904.31  NP_082180.21 
     302563785 
    chicken
    (Gallus gallus)
    Aves CPN21 carboxypeptidase N, polypeptide 2 57.82(n)
    44.31(a)
      424899  XM_422710.4  XP_422710.4 
    lizard
    (Anolis carolinensis)
    Reptilia CPN26
    carboxypeptidase N, polypeptide 2
    43(a)
    1 ↔ 1
    GL343538.1(375683-380205)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017348441 carboxypeptidase N subunit 2-like 45.59(n)
    36.98(a)
      101734844  XM_004914372.1  XP_004914429.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1539131 zgc:153913 48.72(n)
    33.71(a)
      559700  NM_001079979.1  NP_001073448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169746
    --
    12(a)
    1 → many
    2L(13183849-13191979)


    ENSEMBL Gene Tree for CPN2 (if available)
    TreeFam Gene Tree for CPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPN2 gene
    GP52  LRIG32  LRRTM42  CHAD2  LRRC152  LRIG22  LRRTM32  IGFALS2  
    CHADL2  LRIG12  LRRTM22  LRRTM12  LRG12  
    5 SIMAP similar genes for CPN2 using alignment to 1 protein entry:     CPN2_HUMAN:
    ISLR    LGR6    LRIG3    HMFT1766    LRG1

    CPN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CPN2
    PGOHUM00000232632


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPN2 (see all 528)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68062821,2
    C,F,A,H--194060008(+) GTCGCC/TTGGGG 1 -- int125Minor allele frequency- T:0.39EA NS NA WA CSA 2268
    rs748549071,2
    C,F--194060050(+) AAAACG/ACCGCT 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1412683371,2
    --194060053(+) ACGCCA/GGTGCC 1 -- int10--------
    rs67723001,2
    C,F,H--194060054(+) CGCCGG/CTGCCT 1 -- int120Minor allele frequency- C:0.13EA NS NA WA CSA 1091
    rs1907576121,2
    --194060066(+) GGCCCC/TGTTTT 1 -- int10--------
    rs785655751,2
    C--194060080(+) AGATCC/TTGATT 1 -- int14Minor allele frequency- T:0.13CSA WA NA EA 359
    rs1436873001,2
    C--194060106(+) TGGTGG/TTGTGA 1 -- int10--------
    rs1808573101,2
    --194060161(+) TCTCAC/TGCGGG 1 -- int10--------
    rs1123010851,2
    C,F--194060162(+) CTCACG/ACGGGA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1862548231,2
    --194060164(+) CACGCA/GGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CPN2 (194060494 - 194072057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726431CNV Deletion23290073
    esv2563733CNV Insertion19546169
    esv24336CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPN2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603104    OMIM disorders: --

    3 diseases for CPN2:    
    About MalaCards
    corticosterone methyloxidase type ii deficiency    glucocorticoid-remediable aldosteronism    retinitis


    CPN2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CPN2 (185 documents)

    Export disorders for CPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPN2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. (PubMed id 2378615)1, 2, 3 Tan F.... Erdoes E.G. (J. Biol. Chem. 1990)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (Proteomics 2004)
    5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828)1, 3 Riley D.A....Skidgel R.A. (Genomics 1998)
    6. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PubMed id 3408501)1, 2 Skidgel R.A....Erdoes E.G. (Biochem. Biophys. Res. Commun. 1988)
    7. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. (PubMed id 21052031)1 Grilo A....SA!ez M.E. (Pharmacogenet. Genomics 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1370 HGNC: 2313 Ensembl:ENSG00000178772 euGenes: HUgn1370 ECgene: CPN2
    H-InvDB: CPN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPN2 gene:
    Search GeneIP for patents involving CPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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