Aliases for CPN1 Gene
External Ids for CPN1 Gene
Previous GeneCards Identifiers for CPN1 Gene
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPN1 Gene
CPN1 (Carboxypeptidase N, Polypeptide 1) is a Protein Coding gene. Diseases associated with CPN1 include carboxypeptidase n deficiency and pyelitis. Among its related pathways are Transport to the Golgi and subsequent modification and Prostate Cancer. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPD.
UniProtKB/Swiss-Prot for CPN1 Gene
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation