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CPN1 Gene

protein-coding   GIFtS: 64
GCID: GC10M101792

Carboxypeptidase N, Polypeptide 1

(Previous names: carboxypeptidase N, polypeptide 1, 50kD)
  See CPN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase N, Polypeptide 11 2     EC 3.4.17.33 8
Anaphylatoxin Inactivator1 2 3     Carboxypeptidase N, Polypeptide 1, 50kD1
Arginine Carboxypeptidase1 2 3     Carboxypeptidase N Catalytic Chain2
Lysine Carboxypeptidase1 2 3     Carboxypeptidase N Catalytic Subunit2
CPN2 3 5     Carboxypeptidase N Polypeptide 1 50 KD2
SCPN2 3 5     kininase-12
Carboxypeptidase K1 2     ACBP3
Kininase I1 2     Kininase-13
Carboxypeptidase N Small Subunit2 3     Carboxypeptidase N Polypeptide 13
Plasma Carboxypeptidase B2 3     EC 3.4.178
Serum Carboxypeptidase N2 3     

External Ids:    HGNC: 23121   Entrez Gene: 13692   Ensembl: ENSG000001200547   OMIM: 6031035   UniProtKB: P151693   

Export aliases for CPN1 gene to outside databases

Previous GC identifers: GC10M100695 GC10M101035 GC10M101933 GC10M101466 GC10M095429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPN1 Gene:
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and
proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been
known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical
regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in
this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CPN1 Gene:
CPN1 (carboxypeptidase N, polypeptide 1) is a protein-coding gene. Diseases associated with CPN1 include urticaria, and carboxypeptidase n deficiency. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
Function: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys
(such as kinins or anaphylatoxins) which are released into the circulation

Gene Wiki entry for CPN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPN1 gene promoter:
         HFH-3   AhR   p53   p300   Pax-6   Nkx5-1   Arnt   Egr-4   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPN1 promoter sequence
   Search Chromatin IP Primers for CPN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

CPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPN1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M101792:  view genomic region     (about GC identifiers)

Start:
101,801,950 bp from pter      End:
101,841,642 bp from pter
Size:
39,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169 (See protein sequence)
Recommended Name: Carboxypeptidase N catalytic chain precursor  
Size: 458 amino acids; 52286 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Tetramer of two catalytic chains and two glycosylated inactive chains
1 PDB 3D structure from and Proteopedia for CPN1:
2NSM (3D)    
Secondary accessions: B1AP59

Explore the universe of human proteins at neXtProt for CPN1: NX_P15169

Explore proteomics data for CPN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr400, Thr402, Thr409
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CPN1 (P15169) (see all 13)
     GINHDVT  GNMHGNE  VANYPYD  ELSCDKFP 


    See CPN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001299.1  
    ENSEMBL proteins: 
     ENSP00000359446   ENSP00000410895  
    Reactome Protein details: P15169

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    Novus Biologicals CPN1 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPN1

     
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    antibodies-online proteins for CPN1 (4 products) 

     
    antibodies-online peptides for CPN1

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    antibodies-online antibodies for CPN1 (23 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase N, polypeptide 1
    Metallocarboxypeptidases

    4 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14
     IPR027063 CPN1

    Graphical View of Domain Structure for InterPro Entry P15169

    ProtoNet protein and cluster: P15169

    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
    Similarity: Belongs to the peptidase M14 family


    Find genes that share domains with CPN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPN_HUMAN, P15169
    Function: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys
    (such as kinins or anaphylatoxins) which are released into the circulation
    Catalytic activity: Release of a C-terminal basic amino acid, preferentially lysine

         Genatlas biochemistry entry for CPN1:
    carboxypeptidase N catalytic subunit,50kDa

         Enzyme Numbers (IUBMB): EC 3.4.17.31 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CPN1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPN1:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cpn1):
     immune system 

    Find genes that share phenotypes with CPN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cpn1tm1Raw for CPN1

       genOway: Develop your customized and physiologically relevant rodent model for CPN1

    miRNA
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    hsa-miR-3163
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBPN_HUMAN, P15169: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    chloroplast1
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CPN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Prostate Cancer
    Prostate Cancer0.32
    Steroid Biosynthesis0.00
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with CPN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CPN1
        Prostate Cancer
    Steroid Biosynthesis


    1 Reactome Pathway for CPN1
        Insulin processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPN1
    Interactions:

        Search GeneGlobe Interaction Network for CPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CPN1 (P151693 ENSP000003594464) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=2 STRING: ENSP00000245907
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    C5P010313, ENSP000002236424I2D: score=1 STRING: ENSP00000223642
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0051384response to glucocorticoid IEA--

    Find genes that share ontologies with CPN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPN1 (CBPN)

    1 HMDB Compound for CPN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    4 Novoseek inferred chemical compound relationships for CPN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaphylatoxin 79.2 5 11939578 (1), 18039526 (1), 10878383 (1), 12008933 (1)
    lysine 59.6 10 15718415 (3), 8223650 (1), 12008932 (1), 7674952 (1) (see all 8)
    arginine 57.4 10 7517876 (1), 12008932 (1), 14687935 (1), 11939578 (1) (see all 10)
    zinc 9.46 2 14687935 (1), 11342641 (1)



    Find genes that share compounds with CPN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPN1 gene: 
    NM_001308.2  

    Unigene Cluster for CPN1:

    Carboxypeptidase N, polypeptide 1
    Hs.2246  [show with all ESTs]
    Unigene Representative Sequence: BC027897
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370418(uc001kql.2) ENST00000441382
    miRNA
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    hsa-miR-3163
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CPN1
      QuantiFast Probe-based Assays in human, mouse, rat CPN1

    Additional mRNA sequence: 

    AK313972.1 BC027897.1 X14329.1 

    2 DOTS entries:

    DT.408608  DT.100683060 

    Selected AceView cDNA sequences (see all 37):

    CR597710 X14329 CR603435 AI952742 NM_001308 CR608830 BC027897 BI835624 
    BU838862 AI076669 BX098642 BQ676439 BE220892 AL564792 BM042306 AW003077 
    BX431886 AW188007 BX426659 AI827992 BE465608 AV655691 BU172385 AL564473 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPN1 Expression
    About this image


    CPN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Kidney (Urinary System)
             Metanephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Liver (Hepatobiliary System)
    CPN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2246

    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
    Tissue specificity: Synthesized in the liver and secreted in plasma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CPN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpn11 , 5 carboxypeptidase N, polypeptide 11, 5 83.98(n)1
    84.28(a)1
      19 (36.68 cM)5
    937211  NM_030703.21  NP_109628.11 
     439563075 
    chicken
    (Gallus gallus)
    Aves CPN11 carboxypeptidase N, polypeptide 1 72.04(n)
    73.36(a)
      769143  NM_001277254.1  NP_001264183.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPN16
    carboxypeptidase N, polypeptide 1
    66(a)
    1 ↔ 1
    3(38150167-38181285)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684902 hypothetical protein MGC68490 74.58(n)    BC059995.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpn12 carboxypeptidase N, polypeptide 1 74.11(n)   337172  CK238787.1 


    ENSEMBL Gene Tree for CPN1 (if available)
    TreeFam Gene Tree for CPN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPN1 gene
    CPZ2  CPE2  CPXM22  AEBP12  CPD2  CPM2  CPXM12  
    7 SIMAP similar genes for CPN1 using alignment to 2 protein entries:     CBPN_HUMAN (see all proteins):
    CPE    CPZ    CPD    CPM    CPXM2    CPXM1
    DKFZp666J235

    Find genes that share paralogs with CPN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPN1 (see all 784)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617515071,2,,4
    C,FCarboxypeptidase N deficiency (CPND)4 pathogenic1102191116(+) TGGGGC/TCTCCG 2 D G mis13Minor allele frequency- T:0.03NA EU 5919
    rs1133314201,2
    C--101802605(+) GCACTT/-TGGGA 1 -- int13Minor allele frequency- -:0.00NA CSA 8
    rs113953821,2
    C--101803157(+) AAAAGA/-AAAAA 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs42959811,2
    C,F,A,H--101803425(+) CTTTTC/TTTTTT 1 -- int1 trp38Minor allele frequency- T:0.16NS WA NA CSA EA 490
    rs2014839781,2
    --101803425(+) CTTTT-/CTTTTT 1 -- int10--------
    rs342545531,2
    C,F--101804422(+) GTCACC/TGCACC 1 -- int13Minor allele frequency- T:0.33NA 6
    rs348290051,2
    C--101807581(+) AAAAA-/ACCCAC 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs1115630921,2
    C,F--101808993(+) ACAGGC/TGTGAG 1 -- int12Minor allele frequency- T:0.04CSA NA 122
    rs1445189951,2
    C--101810117(+) AATAG-/AACA  
            
    AAACA
    1 -- int10--------
    rs558793341,2
    C--101810119(+) ACAAA-/CAAA  
            
    TCTGT
    1 -- int11Minor allele frequency- CAAA:0.00NA 2

    HapMap Linkage Disequilibrium report for CPN1 (101801950 - 101841642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CPN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825541CNV Gain20364138

    Human Gene Mutation Database (HGMD): CPN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPN1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603103   
    OMIM disorders: 212070  
    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
  • Carboxypeptidase N deficiency (CPND) [MIM:212070]: Patients affected present some combination of
    angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy
    peptidase N, suggestive of autosomal recessive inheritance of this disorder. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for CPN1:    
    About MalaCards
    urticaria    carboxypeptidase n deficiency    angioedema    pyelonephritis

    1 disease from the University of Copenhagen DISEASES database for CPN1:
    Pyelonephritis

    Find genes that share disorders with CPN1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CPN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 8543751 (1)

    Genetic Association Database (GAD): CPN1
    Human Genome Epidemiology (HuGE) Navigator: CPN1 (30 documents)

    Export disorders for CPN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPN1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CPN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1). (PubMed id 2912725)1, 2, 3 Gebhard W.... Eulitz M. (Eur. J. Biochem. 1989)
    2. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. (PubMed id 12560874)1, 2, 9 Cao H. and Hegele R.A. (J. Hum. Genet. 2003)
    3. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828)1, 3, 9 Riley D.A....Skidgel R.A. (Genomics 1998)
    4. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. (PubMed id 20648472)1, 4 Speliotes E.K....Hirschhorn J.N. (Hepatology 2010)
    5. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. On the specificity of carboxypeptidase N, a comparative study. (PubMed id 8267877)1, 2 Hendriks D.... Scharpe S. (Biol. Chem. Hoppe-Seyler 1993)
    9. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PubMed id 3408501)1, 2 Skidgel R.A....Erdoes E.G. (Biochem. Biophys. Res. Commun. 1988)
    10. Carboxypeptidase N: a pleiotropic regulator of inflammation. (PubMed id 14687935)1, 9 Matthews K.W....Wetsel R.A. (Mol. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1369 HGNC: 2312 AceView: CPN1 Ensembl:ENSG00000120054 euGenes: HUgn1369
    ECgene: CPN1 H-InvDB: CPN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPN1 gene:
    Search GeneIP for patents involving CPN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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