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Aliases for CPN1 Gene

Aliases for CPN1 Gene

  • Carboxypeptidase N, Polypeptide 1 2 3
  • Arginine Carboxypeptidase 2 3 4
  • Anaphylatoxin Inactivator 2 3 4
  • Lysine Carboxypeptidase 2 3 4
  • SCPN 3 4 6
  • CPN 3 4 6
  • Carboxypeptidase N Small Subunit 3 4
  • Plasma Carboxypeptidase B 3 4
  • Serum Carboxypeptidase N 3 4
  • Carboxypeptidase K 2 3
  • EC 4 63
  • Kininase I 2 3
  • Kininase-1 3 4
  • Carboxypeptidase N, Polypeptide 1, 50kD 2
  • Carboxypeptidase N Polypeptide 1 50 KD 3
  • Carboxypeptidase N Catalytic Subunit 3
  • Carboxypeptidase N Catalytic Chain 3
  • Carboxypeptidase N Polypeptide 1 4
  • EC 3.4.17 63
  • ACBP 4

External Ids for CPN1 Gene

Previous GeneCards Identifiers for CPN1 Gene

  • GC10M100695
  • GC10M101035
  • GC10M101933
  • GC10M101466
  • GC10M101792
  • GC10M095429

Summaries for CPN1 Gene

Entrez Gene Summary for CPN1 Gene

  • Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPN1 Gene

CPN1 (Carboxypeptidase N, Polypeptide 1) is a Protein Coding gene. Diseases associated with CPN1 include carboxypeptidase n deficiency and urticaria. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Prostate Cancer. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot for CPN1 Gene

  • Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation

Gene Wiki entry for CPN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPN1 Gene

Genomics for CPN1 Gene

Regulatory Elements for CPN1 Gene

Genomic Location for CPN1 Gene

100,042,193 bp from pter
100,081,885 bp from pter
39,693 bases
Minus strand

Genomic View for CPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPN1 Gene

Proteins for CPN1 Gene

  • Protein details for CPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase N catalytic chain
    Protein Accession:
    Secondary Accessions:
    • B1AP59

    Protein attributes for CPN1 Gene

    458 amino acids
    Molecular mass:
    52286 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Tetramer of two catalytic chains and two glycosylated inactive chains.

    Three dimensional structures from OCA and Proteopedia for CPN1 Gene

neXtProt entry for CPN1 Gene

Proteomics data for CPN1 Gene at MOPED

Post-translational modifications for CPN1 Gene

  • Glycosylation at Thr400, Thr402, and Thr409
  • Modification sites at PhosphoSitePlus

Other Protein References for CPN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CPN1 Gene

Gene Families for CPN1 Gene

Protein Domains for CPN1 Gene

Suggested Antigen Peptide Sequences for CPN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P15169
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPN1: view

Function for CPN1 Gene

Molecular function for CPN1 Gene

GENATLAS Biochemistry: carboxypeptidase N catalytic subunit,50kDa
UniProtKB/Swiss-Prot CatalyticActivity: Release of a C-terminal basic amino acid, preferentially lysine
UniProtKB/Swiss-Prot Function: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation

Enzyme Numbers (IUBMB) for CPN1 Gene

Gene Ontology (GO) - Molecular Function for CPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPN1: view

Phenotypes for CPN1 Gene

genes like me logo Genes that share phenotypes with CPN1: view

Animal Models for CPN1 Gene

MGI Knock Outs for CPN1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPN1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CPN1 Gene

Localization for CPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPN1 Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for CPN1 Gene COMPARTMENTS Subcellular localization image for CPN1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
chloroplast 1
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CPN1: view

Pathways for CPN1 Gene

genes like me logo Genes that share pathways with CPN1: view

Pathways by source for CPN1 Gene

2 BioSystems pathways for CPN1 Gene

Gene Ontology (GO) - Biological Process for CPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010815 bradykinin catabolic process IEA --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with CPN1: view

Compounds for CPN1 Gene

(1) HMDB Compounds for CPN1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Zinc

(4) Novoseek inferred chemical compound relationships for CPN1 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 79.2 4
lysine 59.6 10
arginine 57.4 10
zinc 9.46 2
genes like me logo Genes that share compounds with CPN1: view

Transcripts for CPN1 Gene

mRNA/cDNA for CPN1 Gene

(2) REFSEQ mRNAs :
(37) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPN1 Gene

Carboxypeptidase N, polypeptide 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPN1 Gene

No ASD Table

Relevant External Links for CPN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPN1 Gene

mRNA expression in normal human tissues for CPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPN1 Gene

This gene is overexpressed in Liver (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPN1 Gene

SOURCE GeneReport for Unigene cluster for CPN1 Gene Hs.2246

mRNA Expression by UniProt/SwissProt for CPN1 Gene

Tissue specificity: Synthesized in the liver and secreted in plasma
genes like me logo Genes that share expressions with CPN1: view

In Situ Assay Products

Orthologs for CPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPN1 35
  • 88.11 (n)
  • 87.09 (a)
CPN1 36
  • 86 (a)
(Canis familiaris)
Mammalia CPN1 35
  • 88.06 (n)
  • 86.94 (a)
CPN1 36
  • 85 (a)
(Mus musculus)
Mammalia Cpn1 35
  • 83.98 (n)
  • 84.28 (a)
Cpn1 16
Cpn1 36
  • 84 (a)
(Monodelphis domestica)
Mammalia CPN1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
-- 36
  • 67 (a)
-- 36
  • 42 (a)
(Rattus norvegicus)
Mammalia Cpn1 35
  • 83.98 (n)
  • 83.6 (a)
(Gallus gallus)
Aves CPN1 35
  • 72.04 (n)
  • 73.36 (a)
CPN1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia CPN1 36
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68490 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpn1 35
  • 66.9 (n)
  • 71.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9650 35
(Danio rerio)
Actinopterygii cpn1 35
  • 66.11 (n)
  • 71.63 (a)
cpn1 36
  • 51 (a)
cpn1 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 37
  • 41 (a)
(Caenorhabditis elegans)
Secernentea F01D4.4 37
  • 45 (a)
T27A8.1 37
  • 39 (a)
F59A3.1 37
  • 44 (a)
Species with no ortholog for CPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPN1 Gene

Gene Tree for CPN1 (if available)
Gene Tree for CPN1 (if available)

Paralogs for CPN1 Gene

Paralogs for CPN1 Gene

Selected SIMAP similar genes for CPN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPN1: view

Variants for CPN1 Gene

Sequence variations from dbSNP and Humsavar for CPN1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2862924 -- 100,077,499(-) AATCC(C/T)AGCAC intron-variant
rs2862925 -- 100,057,800(-) GACCT(A/G)CTATC intron-variant
rs2862926 -- 100,057,584(-) CCCCT(C/T)ACTGG intron-variant
rs2902364 -- 100,057,785(-) CCCCA(A/G)TACTC intron-variant
rs3750716 -- 100,057,106(+) TCCAG(C/T)GTGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CPN1 Gene

Variant ID Type Subtype PubMed ID
nsv825541 CNV Gain 20364138

Relevant External Links for CPN1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPN1 Gene

Disorders for CPN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for CPN1 Gene including...

Search for CPN1 Gene in MalaCards »

(1) OMIM Diseases for CPN1 Gene (603103)


  • Carboxypeptidase N deficiency (CPND) [MIM:212070]: Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. {ECO:0000269 PubMed:12560874}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CPN1 Gene

(1) Novoseek inferred disease relationships for CPN1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 1

Relevant External Links for CPN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CPN1: view

Publications for CPN1 Gene

  1. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley D.A. … Skidgel R.A. (Genomics 1998) 2 3 23
  2. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. (PMID: 12560874) Cao H. … Hegele R.A. (J. Hum. Genet. 2003) 3 4 23
  3. cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1). (PMID: 2912725) Gebhard W. … Eulitz M. (Eur. J. Biochem. 1989) 2 3 4
  4. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PMID: 3408501) Skidgel R.A. … Erdoes E.G. (Biochem. Biophys. Res. Commun. 1988) 3 4
  5. On the specificity of carboxypeptidase N, a comparative study. (PMID: 8267877) Hendriks D. … Scharpe S. (Biol. Chem. Hoppe-Seyler 1993) 3 4

Products for CPN1 Gene

Sources for CPN1 Gene

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