Aliases for CPN1 Gene
External Ids for CPN1 Gene
Previous GeneCards Identifiers for CPN1 Gene
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPN1 Gene
CPN1 (Carboxypeptidase N, Polypeptide 1) is a Protein Coding gene. Diseases associated with CPN1 include carboxypeptidase n deficiency and urticaria. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Prostate Cancer. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPD.
UniProtKB/Swiss-Prot for CPN1 Gene
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation