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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPN1 Gene

protein-coding   GIFtS: 57
GCID: GC10M101792

carboxypeptidase N, polypeptide 1

(Previous names: carboxypeptidase N, polypeptide 1, 50kD )
 Explore 14 diseases affiliated with
CPN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPN1    

Aliases
for CPN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase N, Polypeptide 11 2     Carboxypeptidase K2
CPN2 3 5     Carboxypeptidase N Catalytic Chain2
SCPN2 3 5     Carboxypeptidase N Catalytic Subunit2
Anaphylatoxin Inactivator2 3     Carboxypeptidase N Polypeptide 1 50 KD2
Arginine Carboxypeptidase2 3     Kininase I2
Carboxypeptidase N Small Subunit2 3     Kininase-13
Lysine Carboxypeptidase2 3     ACBP3
Plasma Carboxypeptidase B2 3     Kininase-13
Serum Carboxypeptidase N2 3     Carboxypeptidase N Polypeptide 13
EC 3.4.17.33 8     EC 3.4.178
Carboxypeptidase N, Polypeptide 1, 50kD1     

External Ids:    HGNC: 23121   Entrez Gene: 13692   Ensembl: ENSG000001200547   OMIM: 6031035   UniProtKB: P151693   

Export aliases for CPN1 gene to outside databases

Previous GC identifers: GC10M100695 GC10M101035 GC10M101933 GC10M101466 GC10M095429


Summaries
for CPN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPN1:
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and
proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been
known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory
subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be
associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
Function: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as
kinins or anaphylatoxins) which are released into the circulation

Gene Wiki entry for CPN1


Genomic Views
for CPN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPN1 gene promoter:
         HFH-3   AhR   p53   p300   Pax-6   Nkx5-1   Arnt   Egr-4   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

CPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPN1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M101792:  view genomic region     (about GC identifiers)

Start:
 101,801,950 bp from pter      End:
 101,841,642 bp from pter
Size:
 39,693 bases      Orientation:
 minus strand

Proteins
for CPN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169 (See protein sequence)
Recommended Name: Carboxypeptidase N catalytic chain precursor  
Size: 458 amino acids; 52286 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Tetramer of two catalytic chains and two glycosylated inactive chains
Subcellular location: Secreted, extracellular space
1 PDB 3D structure from and Proteopedia for CPN1:
2NSM (3D)    

Explore the universe of human proteins at neXtProt for CPN1: NX_P15169

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15169

    • 4/13 DME Specific Peptides for CPN1 (P15169) (see all 13)
     GINHDVT  GNMHGNE  VANYPYD  ELSCDKFP 

    CPN1 Protein expression data from MOPED and PaxDb:    About this image 
    CPN1 Protein Expression
    REFSEQ proteins: NP_001299.1  
    ENSEMBL proteins: 
     ENSP00000359446   ENSP00000410895  

    Human Recombinant Protein Products for CPN1: 
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    OriGene Protein Over-expression Lysate: CPN1
    OriGene Custom Protein Services for CPN1 
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    Novus Biologicals CPN1 Protein
    Novus Biologicals CPN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPN1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CPN1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CPN1

    Protein Domains /
    Families
    for CPN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPN1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14
     IPR027063 CPN1

    Graphical View of Domain Structure for InterPro Entry P15169

    ProtoNet protein and cluster: P15169

    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
    Similarity: Belongs to the peptidase M14 family


    Function
    for CPN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPN_HUMAN, P15169
    Function: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as
    kinins or anaphylatoxins) which are released into the circulation
    Catalytic activity: Release of a C-terminal basic amino acid, preferentially lysine

         Genatlas biochemistry entry for CPN1:
    carboxypeptidase N catalytic subunit,50kDa

         Enzyme Numbers (IUBMB): EC 3.4.17.31 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPN1:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cpn1):
     immune system 

    CPN1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Cpn1tm1Raw for CPN1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPN1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPN1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPN1:
    hsa-miR-3163
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: CPN1
    OriGene siRNA: CPN1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CPN1 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CPN1 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPN1 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for CPN1
    Sirion Biotech Customized stable knockdown cell line services for CPN1 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPN1


    Pathways & Interactions
    for CPN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CPN1 (P151693 ENSP000003594464) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=2 STRING: ENSP00000245907
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    C5P010313, ENSP000002236424I2D: score=1 STRING: ENSP00000223642
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0051384response to glucocorticoid stimulus IEA--

    CPN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPN1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CPN1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPN1

    1 HMDB Compound for CPN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--
    4 Novoseek chemical compound relationships for CPN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaphylatoxin 79.2 5 11939578 (1), 18039526 (1), 10878383 (1), 12008933 (1)
    lysine 59.6 10 15718415 (3), 8223650 (1), 12008932 (1), 7674952 (1) (see all 8)
    arginine 57.4 10 7517876 (1), 12008932 (1), 14687935 (1), 11939578 (1) (see all 10)
    zinc 9.46 2 14687935 (1), 11342641 (1)

    Search CenterWatch for drugs/clinical trials and news about CPN1 / CBPN 

    Transcripts
    for CPN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPN1 gene: 
    NM_001308.2  

    Unigene Cluster for CPN1:

    Carboxypeptidase N, polypeptide 1
    Hs.2246  [show with all ESTs]
    Unigene Representative Sequence: BC027897
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370418(uc001kql.2) ENST00000477709 ENST00000441382 ENST00000472355


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPN1:
    hsa-miR-3163
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPN1 (see all 7)
    OriGene shRNA RFP: CPN1
    OriGene siRNA: CPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPN1
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPN1 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPN1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CPN1 (NM_001308)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPN1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPN1

    Additional cDNA sequence: 

    AK313972.1 BC027897.1 X14329.1 

    2 DOTS entries:

    DT.408608  DT.100683060 

    24/37 AceView cDNA sequences (see all 37):

    AI076669 NM_001308 BX098642 BU838862 CR603435 X14329 BC027897 CR597710 
    AI952742 CR608830 BI835624 BQ676439 BX426659 BE465608 AL564792 AW188007 
    BX431886 BE220892 AI827992 BM042306 AW003077 AA679422 AI287655 AL564473 

    GeneLoc Exon Structure


    Expression
    for CPN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CPN1 Expression
    About this image

    CPN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Primitive gut tube-like cells (A scalable, suspensi...)

    See CPN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPN1

    SOURCE GeneReport for Unigene cluster: Hs.2246

    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
    Tissue specificity: Synthesized in the liver and secreted in plasma

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    In Situ
    Assay Products:     
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    Orthologs
    for CPN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPN1 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPN11 carboxypeptidase N, polypeptide 1 71.88(n)
    72.87(a)    		   769143  XM_001231868.2  XP_001231869.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CPN16
    --
    		 --
    		 70(a)
    49(a)
    		 1 ↔ 1
    possible ortholog
    		 3(38150496-38175491)
    AAWZ02040490(2225-6619)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684902 hypothetical protein MGC68490 74.58(n)    BC059995.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cpn12 carboxypeptidase N, polypeptide 1 74.11(n)   337172  CK238787.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG46783 carboxypeptidase D 41(a)   15A3   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SOL16
    		 putative carboxypeptidase D
    		 30(a)
    		 1 → many
    		 1(26966887-26970572)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 zinc carboxypeptidase family protein, putative, ex...
    		 34(a)
    		 1 → many
    		 6(2357309-2364541)


    ENSEMBL Gene Tree for CPN1 (if available)
    TreeFam Gene Tree for CPN1 (if available) 

    Paralogs
    for CPN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPN1 gene
    CPZ2  CPXM22  CPE2  AEBP12  CPD2  CPXM12  CPM2  
    7 SIMAP similar genes for CPN1 using alignment to 3 protein entries:     CBPN_HUMAN (see all proteins):
    CPE    CPZ    CPD    CPXM1    CPM    CPXM2
    DKFZp666J235

    CPN1 for paralogs           About GeneDecksing



    Genomic Variants
    for CPN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/638 NCBI SNPs in CPN1 are shown (see all 638)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs617515071,2
    		C,Fpathogenic101829514(+) TGGGGC/TCTCCG 2 D G mis13Minor allele frequency- T:0.03NA EU 5919
    rs1444591821,2
    		--101801623(+) AATAGA/GAAAAC 1 -- ds50010--------
    rs761499881,2
    		--101801634(+) CTTACA/CAAACA 1 -- ds50010--------
    rs1860650961,2
    		--101801658(+) GTACTA/GCCACA 1 -- ds50010--------
    rs1424402511,2
    		--101801742(+) TGGTGC/TGATCT 1 -- ds50010--------
    rs1513321411,2
    		--101801932(+) TGCCTC/TGGCCT 1 -- ds50010--------
    rs455185421,2
    		C--101801999(+) TCAATC/AGATCC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs455461351,2
    		--101802095(+) AAATAC/TGTCCC 1 -- ut310--------
    rs617336671,2
    		C,F--101802262(+) ACTCCG/ATGCCT 2 /H syn15Minor allele frequency- A:0.03NS NA EA EU 6167
    rs2003805701,2
    		--101802349(+) AGCAGA/GAGCTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CPN1 (101801950 - 101841642 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CPN1: --
    Human Gene Mutation Database (HGMD): CPN1

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    Disorders / Diseases
    for CPN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPN1 for disorders           About GeneDecksing

    OMIM gene information: 603103   
    OMIM disorders: 212070  
    UniProtKB/Swiss-Prot: CBPN_HUMAN, P15169
  • Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present
    • some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed
    serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder

    14 diseases for CPN1:    About MalaCards
    carboxypeptidase n deficiency    angioedema    urticaria    peroneal nerve paralysis
    lymphogranuloma venereum    polyarteritis nodosa    peroneal neuropathy    pyelonephritis
    fatty liver disease    chronic pyelonephritis    paralysis    liver disease
    neuropathy    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for CPN1:
    Pyelonephritis

    1 Novoseek disease relationship for CPN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 8543751 (1)

    Human Genome Epidemiology (HuGE) Navigator: CPN1 (30 documents)

    Export disorders for CPN1 gene to outside databases

    Publications
    for CPN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPN1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CPN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1). (PubMed id 2912725)1, 2, 3 Gebhard W....Eulitz M. (1989)
    2. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. (PubMed id 12560874)1, 2, 9 Cao H. and Hegele R.A. (2003)
    3. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828)1, 3, 9 Riley D.A....Skidgel R.A. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. On the specificity of carboxypeptidase N, a comparative study. (PubMed id 8267877)1, 2 Hendriks D.... Scharpe S. (1993)
    6. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. (PubMed id 3408501)1, 2 Skidgel R.A....Erdoes E.G. (1988)
    7. Carboxypeptidase N: a pleiotropic regulator of inflammation. (PubMed id 14687935)1, 9 Matthews K.W....Wetsel R.A. (2004)
    8. Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. (PubMed id 10878383)1, 9 Sato T....Okada H. (2000)
    9. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. (PubMed id 17157876)2, 9 Keil C.... Bode W. (2007)
    10. Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. (PubMed id 15718415)1, 9 Davis D.A....Tosato G. (2005)

    External Searches for CPN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CPN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1369 HGNC: 2312 AceView: CPN1 Ensembl:ENSG00000120054 euGenes: HUgn1369
    ECgene: CPN1 H-InvDB: CPN1

    Other Databases showing CPN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CPN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPN1 gene:
    Search GeneIP for patents involving CPN1

    GeneCards and IP:
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