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Aliases for CPM Gene

Aliases for CPM Gene

  • Carboxypeptidase M 2 3
  • Urinary Carboxypeptidase B 2
  • Renal Carboxypeptidase 2
  • EC 3.4.17.12 4
  • EC 3.4.17 63

External Ids for CPM Gene

Previous GeneCards Identifiers for CPM Gene

  • GC12P068885
  • GC12M069120
  • GC12M068952
  • GC12M067534
  • GC12M067531
  • GC12M069244
  • GC12M066295

Summaries for CPM Gene

Entrez Gene Summary for CPM Gene

  • The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPM Gene

CPM (Carboxypeptidase M) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for CPM Gene

  • Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Gene Wiki entry for CPM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPM Gene

Genomics for CPM Gene

Regulatory Elements for CPM Gene

Genomic Location for CPM Gene

Start:
68,842,197 bp from pter
End:
68,971,570 bp from pter
Size:
129,374 bases
Orientation:
Minus strand

Genomic View for CPM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPM Gene

Proteins for CPM Gene

  • Protein details for CPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14384-CBPM_HUMAN
    Recommended name:
    Carboxypeptidase M
    Protein Accession:
    P14384
    Secondary Accessions:
    • B2R800
    • Q9H2K9

    Protein attributes for CPM Gene

    Size:
    443 amino acids
    Molecular mass:
    50514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPM Gene

neXtProt entry for CPM Gene

Proteomics data for CPM Gene at MOPED

Selected DME Specific Peptides for CPM Gene

Post-translational modifications for CPM Gene

  • Glycosylation at Asn38, Asn115, Asn164, Asn363, and Asn384
  • Modification sites at PhosphoSitePlus

Domains for CPM Gene

Gene Families for CPM Gene

Protein Domains for CPM Gene

Suggested Antigen Peptide Sequences for CPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14384

UniProtKB/Swiss-Prot:

CBPM_HUMAN :
  • P14384
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPM: view

Function for CPM Gene

Molecular function for CPM Gene

GENATLAS Biochemistry: carboxypeptidase M,involved in monocyte to macrophage differentiation
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg {ECO:0000269 PubMed:12457462}; KM=57 uM for placental peptide hormones {ECO:0000269 PubMed:12457462}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:12457462};
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of C-terminal arginine or lysine residues from polypeptides
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by O-phenanthroline and MGTA and activated by cobalt
UniProtKB/Swiss-Prot Function: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Enzyme Numbers (IUBMB) for CPM Gene

Gene Ontology (GO) - Molecular Function for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 7797563
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with CPM: view
genes like me logo Genes that share phenotypes with CPM: view

miRNA for CPM Gene

miRTarBase miRNAs that target CPM

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CPM Gene

Localization for CPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPM Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPM Gene COMPARTMENTS Subcellular localization image for CPM gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19581412
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CPM: view

Pathways for CPM Gene

SuperPathways for CPM Gene

No Data Available

Interacting Proteins for CPM Gene

Gene Ontology (GO) - Biological Process for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008152 metabolic process --
GO:0009653 anatomical structure morphogenesis TAS 7797563
genes like me logo Genes that share ontologies with CPM: view

No data available for Pathways by source for CPM Gene

Compounds for CPM Gene

(1) HMDB Compounds for CPM Gene

Compound Synonyms Cas Number PubMed IDs
Cobalt
  • Co
7440-48-4

(5) Novoseek inferred chemical compound relationships for CPM Gene

Compound -log(P) Hits PubMed IDs
cocl2 52.5 1
arginine 40.3 5
lysine 20.7 6
oxygen 0 1
zinc 0 2
genes like me logo Genes that share compounds with CPM: view

Transcripts for CPM Gene

Unigene Clusters for CPM Gene

Carboxypeptidase M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPM Gene

No ASD Table

Relevant External Links for CPM Gene

GeneLoc Exon Structure for
CPM
ECgene alternative splicing isoforms for
CPM

Expression for CPM Gene

mRNA expression in normal human tissues for CPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPM Gene

This gene is overexpressed in Adipose - Subcutaneous (7.5) and Adipose - Visceral (Omentum) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPM Gene

SOURCE GeneReport for Unigene cluster for CPM Gene Hs.654387

genes like me logo Genes that share expressions with CPM: view

No data available for mRNA Expression by UniProt/SwissProt for CPM Gene

Orthologs for CPM Gene

This gene was present in the common ancestor of animals.

Orthologs for CPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPM 35
  • 99.47 (n)
  • 99.1 (a)
CPM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPM 35
  • 86.35 (n)
  • 83.26 (a)
CPM 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPM 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpm 35
  • 81.97 (n)
  • 85.31 (a)
Cpm 16
Cpm 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPM 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPM 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpm 35
  • 83.14 (n)
  • 86.01 (a)
chicken
(Gallus gallus)
Aves CPM 35
  • 68.21 (n)
  • 66.59 (a)
CPM 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPM 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpm 35
  • 63.23 (n)
  • 61.79 (a)
Str.11982 35
zebrafish
(Danio rerio)
Actinopterygii cpm 35
  • 58.03 (n)
  • 53.55 (a)
cpm 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000756 35
  • 51.69 (n)
  • 49.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 35
  • 54.79 (n)
  • 49.45 (a)
CG4678 36
  • 36 (a)
OneToOne
CG4678 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cpd-1 36
  • 16 (a)
ManyToMany
cpd-2 36
  • 31 (a)
ManyToMany
F59A3.1 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for CPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPM Gene

ENSEMBL:
Gene Tree for CPM (if available)
TreeFam:
Gene Tree for CPM (if available)

Paralogs for CPM Gene

Paralogs for CPM Gene

Selected SIMAP similar genes for CPM Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPM: view

Variants for CPM Gene

Sequence variations from dbSNP and Humsavar for CPM Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9817 -- 68,854,168(+) GTCAG(C/T)GTTCA utr-variant-3-prime
rs13486 -- 68,855,307(+) ggatg(A/G)gtatc utr-variant-3-prime
rs727046 -- 68,887,795(-) AAAAT(G/T)TCTTT intron-variant
rs750502 -- 68,913,356(+) TGAGA(G/T)AGTTG intron-variant
rs777465 -- 68,947,566(-) aggct(C/G)gagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPM Gene

Variant ID Type Subtype PubMed ID
nsv512281 CNV Loss 21212237
nsv826408 CNV Gain 20364138
nsv820353 CNV Deletion 20802225
nsv826410 CNV Loss 20364138
esv21511 CNV Gain+Loss 19812545
esv2746013 CNV Deletion 23290073
esv2662286 CNV Deletion 23128226
nsv52755 CNV Loss 16902084
esv2666786 CNV Deletion 23128226
nsv899227 CNV Loss 21882294
nsv523088 CNV Loss 19592680
nsv523272 CNV Loss 19592680

Relevant External Links for CPM Gene

HapMap Linkage Disequilibrium report
CPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPM Gene

Disorders for CPM Gene

(2) Novoseek inferred disease relationships for CPM Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 35.8 1
cancer lung 0 1

Relevant External Links for CPM

Genetic Association Database (GAD)
CPM
Human Genome Epidemiology (HuGE) Navigator
CPM
genes like me logo Genes that share disorders with CPM: view

No data available for UniProtKB/Swiss-Prot for CPM Gene

Publications for CPM Gene

  1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PMID: 15066430) Reverter D. … Bode W. (J. Mol. Biol. 2004) 3 4 23
  2. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PMID: 11934264) Pessoa L.G. … Pesquero J.B. (Biol. Chem. 2002) 3 4 23
  3. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PMID: 12457462) Tan F. … Skidgel R.A. (Biochem. J. 2003) 3 4 23
  4. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A. … Doria A. (Diabetes 2001) 3 4 23
  5. Expression and activity of ectopeptidases in fibrillating human atria. (PMID: 11444929) Lendeckel U. … Goette A. (J. Mol. Cell. Cardiol. 2001) 3 23

Products for CPM Gene

Sources for CPM Gene

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