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CPM Gene

protein-coding   GIFtS: 60
GCID: GC12M069244

Carboxypeptidase M

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase M1 2
Renal Carboxypeptidase1 2
Urinary Carboxypeptidase B1 2
EC 3.4.17.123
EC 3.4.178

External Ids:    HGNC: 23111   Entrez Gene: 13682   Ensembl: ENSG000001356787   OMIM: 1148605   UniProtKB: P143843   

Export aliases for CPM gene to outside databases

Previous GC identifers: GC12P068885 GC12M069120 GC12M068952 GC12M067534 GC12M067531 GC12M066295


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPM Gene:
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is
associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the
amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of
carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding
the same protein have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPM Gene:
CPM (carboxypeptidase M) is a protein-coding gene. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: CBPM_HUMAN, P14384
Function: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed
to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in
the membrane-localized degradation of extracellular proteins

Gene Wiki entry for CPM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPM gene promoter:
         TBP   AML1a   Nkx2-2   Pax-2   FOXD3   Pax-2a   FOXL1   FOXO1a   c-Myb   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPM promoter sequence
   Search Chromatin IP Primers for CPM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

CPM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPM gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M069244:  view genomic region     (about GC identifiers)

Start:
69,235,977 bp from pter      End:
69,365,350 bp from pter
Size:
129,374 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBPM_HUMAN, P14384 (See protein sequence)
Recommended Name: Carboxypeptidase M precursor  
Size: 443 amino acids; 50514 Da
Cofactor: Binds 1 zinc ion per subunit
1 PDB 3D structure from and Proteopedia for CPM:
1UWY (3D)    
Secondary accessions: B2R800 Q9H2K9

Explore the universe of human proteins at neXtProt for CPM: NX_P14384

Explore proteomics data for CPM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn115, Asn164, Asn363, Asn384
  • Selected DME Specific Peptides for CPM (P14384) (see all 7)
     TRIHIMPS  ELSCCKYP  DLNRNFPD  MPSMNPDG 


    See CPM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005502.1  NP_001865.1  NP_938079.1  

    ENSEMBL proteins: 
     ENSP00000447051   ENSP00000447455   ENSP00000448517   ENSP00000447255   ENSP00000446799  
     ENSP00000446573   ENSP00000450400   ENSP00000449911   ENSP00000448078   ENSP00000339157  

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    Sino Biological Recombinant Protein for CPM
    Sino Biological Cell Lysate for CPM
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    Cloud-Clone Corp. Proteins for CPM

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase M
    Metallocarboxypeptidases

    4 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14
     IPR027062 CPM

    Graphical View of Domain Structure for InterPro Entry P14384

    ProtoNet protein and cluster: P14384

    UniProtKB/Swiss-Prot: CBPM_HUMAN, P14384
    Similarity: Belongs to the peptidase M14 family


    Find genes that share domains with CPM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPM_HUMAN, P14384
    Function: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed
    to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in
    the membrane-localized degradation of extracellular proteins
    Catalytic activity: Cleavage of C-terminal arginine or lysine residues from polypeptides
    Enzyme regulation: Inhibited by O-phenanthroline and MGTA and activated by cobalt
    Biophysicochemical properties: Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg; KM=57 uM for placental
    peptide hormones; pH dependence: Optimum pH is 7.0;

         Genatlas biochemistry entry for CPM:
    carboxypeptidase M,involved in monocyte to macrophage differentiation

         Enzyme Numbers (IUBMB): EC 3.4.17.121 EC 3.4.172

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS7797563
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0016788hydrolase activity, acting on ester bonds ----
         
    Find genes that share ontologies with CPM           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPM:
     Increased HPV18 LCR reporter a  Upregulation of Wnt/beta-caten 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CPM:
    hsa-mir-26b-5p (MIRT029472), hsa-mir-124-3p (MIRT022624)

    Block miRNA regulation of human, mouse, rat CPM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPM (see all 52):
    hsa-let-7d hsa-miR-105 hsa-miR-570 hsa-let-7g hsa-miR-1276 hsa-miR-649 hsa-let-7a hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPM

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    Sino Biological Human cDNA Clone for CPM
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBPM_HUMAN, P14384: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    extracellular3
    endoplasmic reticulum2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with CPM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPM
    Interactions:

        GeneGlobe Interaction Network for CPM

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CPM (P143843 ENSP000003391574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HBA2P699053, ENSP000002515954I2D: score=1 STRING: ENSP00000251595
    HBA1P699053I2D: score=1 
    EGFP011333, ENSP000002651714I2D: score=1 STRING: ENSP00000265171
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    NGFENSP000003585254STRING: ENSP00000358525
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008152metabolic process ----
    GO:0009653anatomical structure morphogenesis TAS7797563

    Find genes that share ontologies with CPM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPM (CBPM)

    1 HMDB Compound for CPM    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--

    5 Novoseek inferred chemical compound relationships for CPM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cocl2 52.5 1 2394713 (1)
    arginine 40.3 10 7633739 (1), 18535109 (1), 18292211 (1), 8635221 (1) (see all 5)
    lysine 20.7 9 18292211 (4), 7633739 (1), 16470308 (1)
    oxygen 0 1 8635221 (1)
    zinc 0 2 7626287 (1), 15683985 (1)



    Find genes that share compounds with CPM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPM gene (3 alternative transcripts): 
    NM_001005502.2  NM_001874.4  NM_198320.3  

    Unigene Cluster for CPM:

    Carboxypeptidase M
    Hs.654387  [show with all ESTs]
    Unigene Representative Sequence: NM_001874
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546556 ENST00000551897 ENST00000551568(uc001sup.3 uc001suq.3 uc001sur.3)
    ENST00000546373 ENST00000546912 ENST00000548954 ENST00000551728 ENST00000547134
    ENST00000547924 ENST00000548262 ENST00000549781 ENST00000549691 ENST00000338356

    miRNA
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    Block miRNA regulation of human, mouse, rat CPM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPM (see all 52):
    hsa-let-7d hsa-miR-105 hsa-miR-570 hsa-let-7g hsa-miR-1276 hsa-miR-649 hsa-let-7a hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPM
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPM
      QuantiTect SYBR Green Assays in human, mouse, rat CPM
      QuantiFast Probe-based Assays in human, mouse, rat CPM

    Additional mRNA sequence: 

    AF368463.1 AK130146.1 AK313180.1 BC016943.1 BC022276.1 J04970.2 

    16 DOTS entries:

    DT.121167473  DT.100776887  DT.444867  DT.100710350  DT.75190130  DT.441136  DT.92422069  DT.121167482 
    DT.100719726  DT.100776890  DT.121167414  DT.95259484  DT.100776888  DT.100776893  DT.91727050  DT.100667202 

    Selected AceView cDNA sequences (see all 212):

    BE048967 AI056845 AW573038 BE765208 AU106030 AI918436 NM_198320 AA923509 
    AI270004 AA357912 CD613188 CD613193 AU106031 T49655 BQ706414 BM998545 
    AI141964 NM_001874 AI630005 CR593316 AA486837 AA358218 CD613197 AI421916 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPM Expression
    About this image


    CPM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Diencephalic Ventricular Zone
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    CPM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654387
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPM gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpm1 , 5 carboxypeptidase M1, 5 81.97(n)1
    85.31(a)1
      10 (66.19 cM)5
    705741  NM_027468.11  NP_081744.11 
     1176295005 
    chicken
    (Gallus gallus)
    Aves CPM1 carboxypeptidase M 68.21(n)
    66.59(a)
      417843  NM_001199625.1  NP_001186554.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPM6
    carboxypeptidase M
    62(a)
    1 ↔ 1
    GL343256.1(1460338-1500741)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119822 Transcribed sequence with weak similarity to protein more 75.22(n)    BX729970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI710040.12   -- 72.87(n)    BI710040.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46781 , 3 carboxypeptidase D3
    CG46781
    47(a)3
    54.79(n)1
    49.45(a)1
      15A33
    326521  NM_001144738.11  NP_001138210.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F59A3.13 carboxypeptidase 43(a)   I(5520395-5529523)   --


    ENSEMBL Gene Tree for CPM (if available)
    TreeFam Gene Tree for CPM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPM gene
    CPZ2  CPE2  CPXM22  AEBP12  CPN12  CPD2  CPXM12  
    7 SIMAP similar genes for CPM using alignment to 7 protein entries:     CBPM_HUMAN (see all proteins):
    CPD    CPE    CPN1    CPXM2    DKFZp666J235    CPXM1
    CPZ

    Find genes that share paralogs with CPM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPM (see all 2347)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3731375741,2
    C--69117213(+) AAAAA-/CAACAGC 3 -- int11Minor allele frequency- CA:0.00NA 2
    rs1891402661,2
    --69244539(+) GGTACA/GAGGCT 3 -- ds50010--------
    rs1932278661,2
    --69244602(+) CTTTTA/CTGCAT 3 -- ds50010--------
    rs1854817811,2
    --69244617(+) CAGATA/TCTTTA 3 -- ds50010--------
    rs1488837971,2
    --69244690(+) CCATCA/GTCTTG 3 -- ds50010--------
    rs1440957611,2
    --69244703(+) CATGGA/GACACA 3 -- ds50010--------
    rs27010991,2
    C,F,H--69244743(+) GTATTA/GTATAT 3 -- ds500110Minor allele frequency- G:0.03NS NA WA 1486
    rs733364551,2
    C,F--69244772(+) CATATG/ATAACT 3 -- ds50014Minor allele frequency- A:0.26WA CSA 124
    rs1907860441,2
    --69244793(+) GAACTA/GTCTGG 3 -- ds50010--------
    rs1808365471,2
    --69244948(+) AAAAAA/GGCATT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CPM (69235977 - 69365350 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CPM (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666786CNV Deletion23128226
    esv2746013CNV Deletion23290073
    nsv820353CNV Deletion20802225
    esv2662286CNV Deletion23128226
    nsv523088CNV Loss19592680
    nsv523272CNV Loss19592680
    nsv52755CNV Loss16902084
    nsv826410CNV Loss20364138
    nsv512281CNV Loss21212237
    nsv899227CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114860    OMIM disorders: --


    Find genes that share disorders with CPM           About GenesLikeMe

    2 Novoseek inferred disease relationships for CPM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 35.8 1 15683985 (1)
    cancer lung 0 1 9184569 (1)

    Genetic Association Database (GAD): CPM
    Human Genome Epidemiology (HuGE) Navigator: CPM (78 documents)

    Export disorders for CPM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPM gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with CPM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PubMed id 15066430)1, 2, 9 Reverter D.... Bode W. (J. Mol. Biol. 2004)
    2. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PubMed id 12457462)1, 2, 9 Tan F.... Skidgel R.A. (Biochem. J. 2003)
    3. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PubMed id 11934264)1, 2, 9 Pessoa L.G.... Pesquero J.B. (Biol. Chem. 2002)
    4. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PubMed id 11147789)1, 2, 9 Bektas A.... Doria A. (Diabetes 2001)
    5. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)1, 2 Elortza F.... Jensen O.N. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)1, 2 Elortza F....Jensen O.N. (Mol. Cell. Proteomics 2003)
    8. Physical map location of the human carboxypeptidase M gene (CPM) distal to D12S375 and proximal to D12S8 at chromosome 12q15. (PubMed id 8586455)1, 3 Kas K....Van de Ven W.J. (Genomics 1995)
    9. Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N. (PubMed id 2753907)1, 2 Tan F.... Skidgel R.A. (J. Biol. Chem. 1989)
    10. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization? (PubMed id 18292211)1, 9 Marquez-Curtis L....Janowska-Wieczorek A. (Stem Cells 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1368 HGNC: 2311 AceView: CPM Ensembl:ENSG00000135678 euGenes: HUgn1368
    ECgene: CPM H-InvDB: CPM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPM gene:
    Search GeneIP for patents involving CPM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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