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Aliases for CPM Gene

Aliases for CPM Gene

  • Carboxypeptidase M 2 3 5
  • Urinary Carboxypeptidase B 2
  • Renal Carboxypeptidase 2
  • EC 3.4.17.12 4
  • EC 3.4.17 63

External Ids for CPM Gene

Previous GeneCards Identifiers for CPM Gene

  • GC12P068885
  • GC12M069120
  • GC12M068952
  • GC12M067534
  • GC12M067531
  • GC12M069244
  • GC12M066295

Summaries for CPM Gene

Entrez Gene Summary for CPM Gene

  • The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPM Gene

CPM (Carboxypeptidase M) is a Protein Coding gene. Diseases associated with CPM include liposarcoma and dentine erosion. GO annotations related to this gene include hydrolase activity, acting on ester bonds and carboxypeptidase activity. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot for CPM Gene

  • Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Gene Wiki entry for CPM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPM Gene

Genomics for CPM Gene

Regulatory Elements for CPM Gene

Genomic Location for CPM Gene

Chromosome:
12
Start:
68,842,197 bp from pter
End:
68,971,570 bp from pter
Size:
129,374 bases
Orientation:
Minus strand

Genomic View for CPM Gene

Genes around CPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPM Gene

Proteins for CPM Gene

  • Protein details for CPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14384-CBPM_HUMAN
    Recommended name:
    Carboxypeptidase M
    Protein Accession:
    P14384
    Secondary Accessions:
    • B2R800
    • Q9H2K9

    Protein attributes for CPM Gene

    Size:
    443 amino acids
    Molecular mass:
    50514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPM Gene

neXtProt entry for CPM Gene

Proteomics data for CPM Gene at MOPED

Selected DME Specific Peptides for CPM Gene

Post-translational modifications for CPM Gene

  • Glycosylation at Asn 38, Asn 115, Asn 164, Asn 363, and Asn 384
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CPM (Carboxypeptidase M)

Domains & Families for CPM Gene

Gene Families for CPM Gene

Protein Domains for CPM Gene

Suggested Antigen Peptide Sequences for CPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14384

UniProtKB/Swiss-Prot:

CBPM_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPM: view

Function for CPM Gene

Molecular function for CPM Gene

GENATLAS Biochemistry:
carboxypeptidase M,involved in monocyte to macrophage differentiation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg {ECO:0000269 PubMed:12457462}; KM=57 uM for placental peptide hormones {ECO:0000269 PubMed:12457462}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:12457462};
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of C-terminal arginine or lysine residues from polypeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-phenanthroline and MGTA and activated by cobalt.
UniProtKB/Swiss-Prot Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Enzyme Numbers (IUBMB) for CPM Gene

genes like me logo Genes that share phenotypes with CPM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPM

miRNA for CPM Gene

miRTarBase miRNAs that target CPM

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPM Gene

Localization for CPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPM Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPM Gene COMPARTMENTS Subcellular localization image for CPM gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CPM: view

Pathways & Interactions for CPM Gene

SuperPathways for CPM Gene

No Data Available

Interacting Proteins for CPM Gene

Gene Ontology (GO) - Biological Process for CPM Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPM Gene

Drugs & Compounds for CPM Gene

(16) Drugs for CPM Gene - From: Novoseek, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pregabalin Approved, Illicit, Investigational Pharma 340
Analgesics Pharma 9358
Anti-Anxiety Agents Pharma 1529
Anticonvulsants Pharma 2249
calcium channel blockers Pharma 1743

(2) Additional Compounds for CPM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPM: view

Transcripts for CPM Gene

Unigene Clusters for CPM Gene

Carboxypeptidase M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPM Gene

No ASD Table

Relevant External Links for CPM Gene

GeneLoc Exon Structure for
CPM
ECgene alternative splicing isoforms for
CPM

Expression for CPM Gene

mRNA expression in normal human tissues for CPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPM Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.5) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for CPM Gene

This gene is overexpressed in Cervix (47.4) and Adipocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPM Gene



SOURCE GeneReport for Unigene cluster for CPM Gene Hs.654387

genes like me logo Genes that share expression patterns with CPM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CPM Gene

Orthologs for CPM Gene

This gene was present in the common ancestor of animals.

Orthologs for CPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPM 36
  • 99 (a)
OneToOne
CPM 35
  • 99.47 (n)
  • 99.1 (a)
cow
(Bos Taurus)
Mammalia CPM 35
  • 86.35 (n)
  • 83.26 (a)
CPM 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPM 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpm 16
Cpm 35
  • 81.97 (n)
  • 85.31 (a)
Cpm 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPM 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPM 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpm 35
  • 83.14 (n)
  • 86.01 (a)
chicken
(Gallus gallus)
Aves CPM 35
  • 68.21 (n)
  • 66.59 (a)
CPM 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPM 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpm 35
  • 63.23 (n)
  • 61.79 (a)
Str.11982 35
zebrafish
(Danio rerio)
Actinopterygii cpm 36
  • 50 (a)
OneToOne
cpm 35
  • 58.03 (n)
  • 53.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000756 35
  • 51.69 (n)
  • 49.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 36
  • 36 (a)
OneToOne
CG4678 35
  • 54.79 (n)
  • 49.45 (a)
CG4678 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A3.1 37
  • 43 (a)
cpd-1 36
  • 16 (a)
ManyToMany
cpd-2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for CPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPM Gene

ENSEMBL:
Gene Tree for CPM (if available)
TreeFam:
Gene Tree for CPM (if available)

Paralogs for CPM Gene

Paralogs for CPM Gene

(7) SIMAP similar genes for CPM Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPM: view

Variants for CPM Gene

Sequence variations from dbSNP and Humsavar for CPM Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7978197 - 68,932,767(+) CCTGG(C/T)GGTGG reference, missense, utr-variant-5-prime
rs7309831 - 68,871,818(+) TTTGA(C/T)GGCTT reference, synonymous-codon, missense
rs777465 -- 68,947,566(-) aggct(C/G)gagtg intron-variant
rs777466 -- 68,947,545(-) atctc(A/G)gctca intron-variant
rs777467 -- 68,947,512(-) tcaag(A/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPM Gene

Variant ID Type Subtype PubMed ID
nsv512281 CNV Loss 21212237
nsv826408 CNV Gain 20364138
nsv820353 CNV Deletion 20802225
nsv826410 CNV Loss 20364138
esv21511 CNV Gain+Loss 19812545
esv2746013 CNV Deletion 23290073
esv2662286 CNV Deletion 23128226
nsv52755 CNV Loss 16902084
esv2666786 CNV Deletion 23128226
nsv899227 CNV Loss 21882294
nsv523088 CNV Loss 19592680
nsv523272 CNV Loss 19592680

Variation tolerance for CPM Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 84.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPM Gene

HapMap Linkage Disequilibrium report
CPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPM Gene

Disorders for CPM Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
liposarcoma
dentine erosion
- elite association - COSMIC cancer census association via MalaCards
Search CPM in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPM

Genetic Association Database (GAD)
CPM
Human Genome Epidemiology (HuGE) Navigator
CPM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPM
genes like me logo Genes that share disorders with CPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPM Gene

Publications for CPM Gene

  1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PMID: 15066430) Reverter D. … Bode W. (J. Mol. Biol. 2004) 3 4 23 67
  2. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. (PMID: 19820690) Erickson-Johnson M.R. … Oliveira A.M. (Mod. Pathol. 2009) 3 23
  3. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists. (PMID: 18187413) Zhang X. … Skidgel R.A. (J. Biol. Chem. 2008) 3 23
  4. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization? (PMID: 18292211) Marquez-Curtis L. … Janowska-Wieczorek A. (Stem Cells 2008) 3 23
  5. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PMID: 12457462) Tan F. … Skidgel R.A. (Biochem. J. 2003) 3 23

Products for CPM Gene

Sources for CPM Gene

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