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Aliases for CPM Gene

Aliases for CPM Gene

  • Carboxypeptidase M 2 3 5
  • Urinary Carboxypeptidase B 2
  • Renal Carboxypeptidase 2
  • EC 3.4.17.12 4
  • EC 3.4.17 61

External Ids for CPM Gene

Previous GeneCards Identifiers for CPM Gene

  • GC12P068885
  • GC12M069120
  • GC12M068952
  • GC12M067534
  • GC12M067531
  • GC12M069244
  • GC12M066295

Summaries for CPM Gene

Entrez Gene Summary for CPM Gene

  • The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPM Gene

CPM (Carboxypeptidase M) is a Protein Coding gene. Diseases associated with CPM include Atypical Lipomatous Tumor. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include hydrolase activity, acting on ester bonds and carboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot for CPM Gene

  • Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Gene Wiki entry for CPM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPM Gene

Genomics for CPM Gene

Regulatory Elements for CPM Gene

Enhancers for CPM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F068961 1.5 FANTOM5 Ensembl ENCODE 51.9 +8.3 8303 3.0 CTCF PKNOX1 SAP130 ZNF384 ZBTB40 RAD21 ZNF335 SMC3 NFE2 ZNF600 CPM RAP1B LYZ PRELID2P1
GH12F069054 1.2 FANTOM5 Ensembl ENCODE 57.3 -84.3 -84332 2.2 ATF3 CEBPA ARID4B CEBPB HMG20A YY1 CPM RAP1B LYZ GC12M069009 GC12M069139
GH12F069006 1.5 FANTOM5 Ensembl ENCODE 37.6 -36.2 -36221 3.6 TBP PKNOX1 FEZF1 BRCA1 RFX5 SCRT2 SMARCC2 FOS ZNF362 CEBPB CPM FRS2 RAP1B LYZ CPSF6 MDM2 YEATS4 SLC35E3 NUP107 GC12M069009
GH12F069052 1.5 FANTOM5 Ensembl ENCODE 18.9 -81.6 -81643 2.4 ARID4B THRB RAD21 RARA YY1 GATA4 FOS CREM SMARCC1 HMG20B CPM RAP1B LYZ GC12M069009 GC12M069139
GH12F068783 1.6 FANTOM5 Ensembl ENCODE 15.1 +185.0 184970 5.6 ATF1 ARID4B FEZF1 DMAP1 YY1 SLC30A9 SP5 REST TBX21 PPARG MDM2 RAP1B CPM SLC35E3 LOC100130075 NUP107 LOC105369820
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPM on UCSC Golden Path with GeneCards custom track

Genomic Location for CPM Gene

Chromosome:
12
Start:
68,842,197 bp from pter
End:
68,971,570 bp from pter
Size:
129,374 bases
Orientation:
Minus strand

Genomic View for CPM Gene

Genes around CPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPM Gene

Proteins for CPM Gene

  • Protein details for CPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14384-CBPM_HUMAN
    Recommended name:
    Carboxypeptidase M
    Protein Accession:
    P14384
    Secondary Accessions:
    • B2R800
    • Q9H2K9

    Protein attributes for CPM Gene

    Size:
    443 amino acids
    Molecular mass:
    50514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPM Gene

neXtProt entry for CPM Gene

Selected DME Specific Peptides for CPM Gene

P14384:
  • PEFKYVANMHG
  • FVLSANLHGG
  • DLNRNFPD
  • MPSMNPDG
  • CFEITLELSC
  • ELSCCKYP
  • TRIHIMPS

Post-translational modifications for CPM Gene

  • Glycosylation at Asn 38, Asn 115, Asn 164, Asn 363, and Asn 384
  • Modification sites at PhosphoSitePlus

Domains & Families for CPM Gene

Gene Families for CPM Gene

Suggested Antigen Peptide Sequences for CPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14384

UniProtKB/Swiss-Prot:

CBPM_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPM: view

Function for CPM Gene

Molecular function for CPM Gene

GENATLAS Biochemistry:
carboxypeptidase M,involved in monocyte to macrophage differentiation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg {ECO:0000269 PubMed:12457462}; KM=57 uM for placental peptide hormones {ECO:0000269 PubMed:12457462}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:12457462};
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of C-terminal arginine or lysine residues from polypeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-phenanthroline and MGTA and activated by cobalt.
UniProtKB/Swiss-Prot Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Enzyme Numbers (IUBMB) for CPM Gene

Gene Ontology (GO) - Molecular Function for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA,TAS 7797563
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0004185 serine-type carboxypeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPM: view
genes like me logo Genes that share phenotypes with CPM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPM

miRNA for CPM Gene

miRTarBase miRNAs that target CPM

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPM Gene

Localization for CPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPM Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPM gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CPM: view

Pathways & Interactions for CPM Gene

genes like me logo Genes that share pathways with CPM: view

Gene Ontology (GO) - Biological Process for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:0009653 anatomical structure morphogenesis TAS 7797563
GO:0016485 protein processing IBA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CPM: view

No data available for SIGNOR curated interactions for CPM Gene

Drugs & Compounds for CPM Gene

(24) Drugs for CPM Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 3759
Norepinephrine Approved Pharma 683
Pregabalin Approved, Illicit, Investigational Pharma GABA analog/VDCC ligand;anticonvulsant/anxiolytic analgesic, Anticonvulsant; selectively binds the alpha2delta subunit of voltage-sensitive calcium channels 355
Analgesics Pharma 11287
Anti-Anxiety Agents Pharma 1816

(1) Additional Compounds for CPM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPM: view

Transcripts for CPM Gene

Unigene Clusters for CPM Gene

Carboxypeptidase M:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPM Gene

No ASD Table

Relevant External Links for CPM Gene

GeneLoc Exon Structure for
CPM
ECgene alternative splicing isoforms for
CPM

Expression for CPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPM Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.5) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for CPM Gene

This gene is overexpressed in Cervix (47.4) and Adipocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPM Gene



NURSA nuclear receptor signaling pathways regulating expression of CPM Gene:

CPM

SOURCE GeneReport for Unigene cluster for CPM Gene:

Hs.654387
genes like me logo Genes that share expression patterns with CPM: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CPM Gene

Orthologs for CPM Gene

This gene was present in the common ancestor of animals.

Orthologs for CPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPM 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia CPM 34 35
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Cpm 34
  • 83.14 (n)
mouse
(Mus musculus)
Mammalia Cpm 34 16 35
  • 81.97 (n)
dog
(Canis familiaris)
Mammalia CPM 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPM 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPM 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPM 34 35
  • 68.21 (n)
lizard
(Anolis carolinensis)
Reptilia CPM 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpm 34
  • 63.23 (n)
Str.11982 34
zebrafish
(Danio rerio)
Actinopterygii cpm 34 35
  • 58.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 36 34 35
  • 54.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000756 34
  • 51.69 (n)
worm
(Caenorhabditis elegans)
Secernentea F59A3.1 36
  • 43 (a)
cpd-2 35
  • 31 (a)
ManyToMany
cpd-1 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
ManyToMany
Species where no ortholog for CPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPM Gene

ENSEMBL:
Gene Tree for CPM (if available)
TreeFam:
Gene Tree for CPM (if available)

Paralogs for CPM Gene

Paralogs for CPM Gene

(7) SIMAP similar genes for CPM Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPM: view

Variants for CPM Gene

Sequence variations from dbSNP and Humsavar for CPM Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1047283 -- 68,844,295(+) TTTTT(C/T)TGGAA intron-variant, utr-variant-3-prime
rs10530969 -- 68,957,322(+) CTCAG(-/A)AAAAA intron-variant
rs10564575 -- 68,890,369(+) AATTT(-/A)AAAAA intron-variant
rs10568993 -- 68,905,214(+) CAAAA(-/TATA)GAAAC intron-variant
rs1057997 -- 68,845,398(+) GCTAA(A/C)AAACG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPM Gene

Variant ID Type Subtype PubMed ID
nsv826410 CNV loss 20364138
nsv826408 CNV gain 20364138
nsv820353 CNV deletion 20802225
nsv559222 CNV loss 21841781
nsv559221 CNV loss 21841781
nsv559220 CNV loss 21841781
nsv52755 CNV deletion 16902084
nsv523272 CNV loss 19592680
nsv523088 CNV loss 19592680
nsv512281 CNV loss 21212237
nsv1071040 CNV deletion 25765185
nsv1042799 CNV gain 25217958
esv3629861 CNV gain 21293372
esv3629860 CNV loss 21293372
esv3629859 CNV loss 21293372
esv3549349 CNV deletion 23714750
esv2746013 CNV deletion 23290073
esv2666786 CNV deletion 23128226
esv2662286 CNV deletion 23128226
esv21511 CNV gain+loss 19812545

Variation tolerance for CPM Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 84.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPM Gene

Disorders for CPM Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPM Gene - From: DISEASES

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • pleomorphic lipoma
- elite association - COSMIC cancer census association via MalaCards
Search CPM in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPM

Genetic Association Database (GAD)
CPM
Human Genome Epidemiology (HuGE) Navigator
CPM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPM
genes like me logo Genes that share disorders with CPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPM Gene

Publications for CPM Gene

  1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PMID: 15066430) Reverter D. … Bode W. (J. Mol. Biol. 2004) 3 4 22 64
  2. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PMID: 12457462) Tan F. … Skidgel R.A. (Biochem. J. 2003) 3 4 22 64
  3. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PMID: 11934264) Pessoa L.G. … Pesquero J.B. (Biol. Chem. 2002) 3 4 22 64
  4. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A. … Doria A. (Diabetes 2001) 3 4 22 64
  5. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. (PMID: 19820690) Erickson-Johnson M.R. … Oliveira A.M. (Mod. Pathol. 2009) 3 22 64

Products for CPM Gene

Sources for CPM Gene

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