CPM Gene

Aliases
for CPM gene

Previous GC identifers: GC12P068885 GC12M069120 GC12M068952 GC12M067534 GC12M067531 GC12M066295

Summaries
for CPM gene

Genomic Views
for CPM gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPM promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPM

CPM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M069244:  view genomic region     (about GC identifiers)

Proteins
for CPM gene

1 PDB 3D structure from and Proteopedia for CPM:

1UWY (3D)    

Explore the universe of human proteins at neXtProt for CPM: NX_P14384

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CPM (Carboxypeptidase M)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CPM OriGene Custom Protein Services for CPM
	GenScript Custom Purified and Recombinant Proteins Services for CPM
	Novus Biologicals CPM Proteins Novus Biologicals CPM Lysates
	Sino Biological Recombinant Protein for CPM
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CPM

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CPM (Carboxypeptidase M)
	OriGene Antibodies: CPM OriGene Custom Antibody Services for CPM
	GenScript Custom Superior Antibodies Services for CPM
	Novus Biologicals CPM Antibodies
	Abcam antibodies for CPM
	Uscn Antibodies for CPM
	ThermoFisher Antibodies for CPM

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CPM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CPM

Protein Domains /
Families
for CPM gene

ProtoNet protein and cluster: P14384

Function
for CPM gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CPM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPM
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate CPM (see all 52):
		hsa-let-7d hsa-miR-105 hsa-miR-570 hsa-let-7g hsa-miR-1276 hsa-miR-649 hsa-let-7a hsa-miR-376a*
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPM (see all 7) OriGene siRNA: CPM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPM

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CPM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPM (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPM (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CPM (NM_001874)
		Sino Biological Human cDNA Clone for CPM
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CPM
		Search LifeMap BioReagents cell lines for CPM

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPM

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for CPM gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CPM gene

Transcripts
for CPM gene

Expression
for CPM gene

CPM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LimbForelimb MyotomeLimb Muscle Progenitor Cells			Skeletal Muscle
	Head MesenchymeFrontonasal Process			Head Mesenchyme
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPM

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPM

Orthologs
for CPM gene

Paralogs
for CPM gene

Paralogs for CPM gene

CPZ²  CPXM2²  CPE²  AEBP1²  CPN1²  CPD²  CPXM1²  

7 SIMAP similar genes for CPM using alignment to 7 protein entries:     CBPM_HUMAN (see all proteins):

CPD    CPE    CPN1    DKFZp666J235    CPXM2    CPXM1

CPZ

CPM for paralogs           About GeneDecksing

Genomic Variants
for CPM gene

10/2051 NCBI SNPs in CPM are shown (see all 2051)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1891402661,2		--	69244539(+)	GGTACA/GAGGCT	3	--	ds5001		0	--	--	--	--
rs1932278661,2		--	69244602(+)	CTTTTA/CTGCAT	3	--	ds5001		0	--	--	--	--
rs1854817811,2		--	69244617(+)	CAGATA/TCTTTA	3	--	ds5001		0	--	--	--	--
rs1488837971,2		--	69244690(+)	CCATCA/GTCTTG	3	--	ds5001		0	--	--	--	--
rs1440957611,2		--	69244703(+)	CATGGA/GACACA	3	--	ds5001		0	--	--	--	--
rs27010991,2	C,F,H,	--	69244743(+)	GTATTA/GTATAT	3	--	ds5001		10		NS NA WA	1486
rs733364551,2	C,F,	--	69244772(+)	CATATG/ATAACT	3	--	ds5001		4		WA CSA	124
rs1907860441,2		--	69244793(+)	GAACTA/GTCTGG	3	--	ds5001		0	--	--	--	--
rs1808365471,2		--	69244948(+)	AAAAAA/GGCATT	3	--	ds5001		0	--	--	--	--
rs1163577531,2	F,	--	69245164(+)	AGGCAG/AGCAGA	3	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for CPM (69235977 - 69365350 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CPM
     4 Indels: 66258 86439 76069 11626

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPM

DNA2.0 Custom Variant and Variant Library Synthesis for CPM

Disorders / Diseases
for CPM gene

8 diseases for CPM

2 Novoseek disease relationships for CPM gene    About this table

Publications
for CPM gene

PubMed articles for CPM gene, integrated from 9 sources (see all 76): (articles sorted by number of sources associating them with CPM)

Utopia: connect your pdf to the dynamic world of online information

1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PubMed id 15066430)^{1, 2, 9} Reverter D.... Bode W. (2004)
2. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PubMed id 12457462)^{1, 2, 9} Tan F.... Skidgel R.A. (2003)
3. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PubMed id 11934264)^{1, 2, 9} Pessoa L.G.... Pesquero J.B. (2002)
4. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PubMed id 11147789)^{1, 2, 9} Bektas A.... Doria A. (2001)
5. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)^{1, 2} Elortza F.... Jensen O.N. (2006)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)^{1, 2} Elortza F....Jensen O.N. (2003)
8. Physical map location of the human carboxypeptidase M gene (CPM) distal to D12S375 and proximal to D12S8 at chromosome 12q15. (PubMed id 8586455)^{1, 3} Kas K....Van de Ven W.J. (1995)
9. Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N. (PubMed id 2753907)^{1, 2} Tan F.... Skidgel R.A. (1989)
10. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization? (PubMed id 18292211)^{1, 9} Marquez-Curtis L....Janowska-Wieczorek A. (2008)

External Searches for CPM gene

Genome Databases showing CPM gene

Other Databases showing CPM gene

Specialized Databases showing CPM gene

Products
for CPM gene