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Aliases for CPLX4 Gene

Aliases for CPLX4 Gene

  • Complexin 4 2 3 5
  • Complexin IV 3 4
  • CPX IV 3 4
  • CPX-IV 3
  • CPXIV 3

External Ids for CPLX4 Gene

Previous GeneCards Identifiers for CPLX4 Gene

  • GC18M056748
  • GC18M055112
  • GC18M055111
  • GC18M055113
  • GC18M056962
  • GC18M053671

Summaries for CPLX4 Gene

Entrez Gene Summary for CPLX4 Gene

  • This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]

GeneCards Summary for CPLX4 Gene

CPLX4 (Complexin 4) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle. GO annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX3.

UniProtKB/Swiss-Prot for CPLX4 Gene

  • Positively regulates a late step in synaptic vesicle exocytosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX4 Gene

Genomics for CPLX4 Gene

Regulatory Elements for CPLX4 Gene

Enhancers for CPLX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPLX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPLX4 Gene

59,275,156 bp from pter
59,318,649 bp from pter
43,494 bases
Minus strand

Genomic View for CPLX4 Gene

Genes around CPLX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPLX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPLX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX4 Gene

Proteins for CPLX4 Gene

  • Protein details for CPLX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • F1T0L6

    Protein attributes for CPLX4 Gene

    160 amino acids
    Molecular mass:
    18336 Da
    Quaternary structure:
    • Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

neXtProt entry for CPLX4 Gene

Proteomics data for CPLX4 Gene at MOPED

Post-translational modifications for CPLX4 Gene

  • Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPLX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPLX4 Gene

Domains & Families for CPLX4 Gene

Protein Domains for CPLX4 Gene


Suggested Antigen Peptide Sequences for CPLX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complexin/synaphin family.
  • Belongs to the complexin/synaphin family.
genes like me logo Genes that share domains with CPLX4: view

No data available for Gene Families for CPLX4 Gene

Function for CPLX4 Gene

Molecular function for CPLX4 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates a late step in synaptic vesicle exocytosis.

Phenotypes for CPLX4 Gene

MGI mutant phenotypes for CPLX4:
inferred from 1 alleles
GenomeRNAi human phenotypes for CPLX4:
genes like me logo Genes that share phenotypes with CPLX4: view

Animal Models for CPLX4 Gene

MGI Knock Outs for CPLX4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CPLX4 Gene

Localization for CPLX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX4 Gene

Membrane; Lipid-anchor. Cell junction, synapse. Note=Enriched at the synaptic terminal. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CPLX4 Gene COMPARTMENTS Subcellular localization image for CPLX4 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for CPLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CPLX4: view

Pathways & Interactions for CPLX4 Gene

SuperPathways for CPLX4 Gene

Superpath Contained pathways
1 Synaptic vesicle cycle
genes like me logo Genes that share pathways with CPLX4: view

Pathways by source for CPLX4 Gene

1 KEGG pathway for CPLX4 Gene

Interacting Proteins for CPLX4 Gene

Gene Ontology (GO) - Biological Process for CPLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with CPLX4: view

No data available for SIGNOR curated interactions for CPLX4 Gene

Drugs & Compounds for CPLX4 Gene

No Compound Related Data Available

Transcripts for CPLX4 Gene

mRNA/cDNA for CPLX4 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPLX4 Gene

Complexin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX4 Gene

No ASD Table

Relevant External Links for CPLX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPLX4 Gene

mRNA expression in normal human tissues for CPLX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX4 Gene

This gene is overexpressed in Brain - Cerebellum (x21.4) and Brain - Cerebellar Hemisphere (x20.7).

Protein differential expression in normal tissues from HIPED for CPLX4 Gene

This gene is overexpressed in Retina (54.9) and Heart (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPLX4 Gene

SOURCE GeneReport for Unigene cluster for CPLX4 Gene Hs.449884

genes like me logo Genes that share expression patterns with CPLX4: view

Protein tissue co-expression partners for CPLX4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPLX4 Gene

Orthologs for CPLX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPLX4 35
  • 89.79 (n)
  • 94.37 (a)
CPLX4 36
  • 94 (a)
(Canis familiaris)
Mammalia CPLX4 35
  • 92.71 (n)
  • 95 (a)
CPLX4 36
  • 91 (a)
(Mus musculus)
Mammalia Cplx4 35
  • 87.29 (n)
  • 91.87 (a)
Cplx4 16
Cplx4 36
  • 92 (a)
(Pan troglodytes)
Mammalia CPLX4 35
  • 99.79 (n)
  • 100 (a)
CPLX4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cplx4 35
  • 86.25 (n)
  • 91.87 (a)
(Monodelphis domestica)
Mammalia CPLX4 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CPLX4 36
  • 89 (a)
(Gallus gallus)
Aves CPLX4 35
  • 80 (n)
  • 87.5 (a)
CPLX4 36
  • 88 (a)
(Anolis carolinensis)
Reptilia CPLX4 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cplx4 35
  • 72.5 (n)
  • 76.87 (a)
Str.12479 35
(Danio rerio)
Actinopterygii cplx4a 35
  • 68.76 (n)
  • 74.21 (a)
cplx4a 36
  • 74 (a)
cplx4b 36
  • 68 (a)
Species with no ortholog for CPLX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX4 Gene

Gene Tree for CPLX4 (if available)
Gene Tree for CPLX4 (if available)

Paralogs for CPLX4 Gene

Paralogs for CPLX4 Gene

(1) SIMAP similar genes for CPLX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPLX4: view

Variants for CPLX4 Gene

Sequence variations from dbSNP and Humsavar for CPLX4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs473567 -- 59,302,760(-) ATCCA(A/G)GTCCA intron-variant
rs478602 -- 59,309,816(+) agact(C/T)tgtgt intron-variant
rs499824 -- 59,295,601(-) CCAAA(C/T)CAAAA utr-variant-3-prime
rs508858 -- 59,301,195(+) GGCAG(A/G)GCGTT intron-variant
rs509886 -- 59,301,080(+) GCCTT(A/G)GGACC intron-variant

Variation tolerance for CPLX4 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CPLX4 Gene

Disorders for CPLX4 Gene

Relevant External Links for CPLX4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPLX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPLX4 Gene

Publications for CPLX4 Gene

  1. Structurally and functionally unique complexins at retinal ribbon synapses. (PMID: 15911881) Reim K. … Brose N. (J. Cell Biol. 2005) 2 3 4 67
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  3. The carboxy-terminal domain of complexin I stimulates liposome fusion. (PMID: 19179400) Malsam J. … SAPllner T.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CPLX4 Gene

Sources for CPLX4 Gene