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Aliases for CPLX3 Gene

Aliases for CPLX3 Gene

  • Complexin 3 2 3 5
  • Complexin III 3 4
  • CPX III 3 4
  • Nbla11589 3
  • CPX-III 3
  • CPXIII 3

External Ids for CPLX3 Gene

Previous GeneCards Identifiers for CPLX3 Gene

  • GC15U900493
  • GC15P072906
  • GC15P075118
  • GC15P051915

Summaries for CPLX3 Gene

GeneCards Summary for CPLX3 Gene

CPLX3 (Complexin 3) is a Protein Coding gene. Diseases associated with CPLX3 include Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Synaptic vesicle cycle. GO annotations related to this gene include syntaxin binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX4.

UniProtKB/Swiss-Prot for CPLX3 Gene

  • Positively regulates a late step in synaptic vesicle exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX3 Gene

Genomics for CPLX3 Gene

Regulatory Elements for CPLX3 Gene

Enhancers for CPLX3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPLX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPLX3 Gene

74,826,547 bp from pter
74,831,802 bp from pter
5,256 bases
Plus strand

Genomic View for CPLX3 Gene

Genes around CPLX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPLX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPLX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX3 Gene

Proteins for CPLX3 Gene

  • Protein details for CPLX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DW66
    • Q8TEM6
    • Q9H818

    Protein attributes for CPLX3 Gene

    158 amino acids
    Molecular mass:
    17557 Da
    Quaternary structure:
    • Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
    • Sequence=BAB84922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CPLX3 Gene

Proteomics data for CPLX3 Gene at MOPED

Post-translational modifications for CPLX3 Gene

Other Protein References for CPLX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPLX3 Gene

Domains & Families for CPLX3 Gene

Protein Domains for CPLX3 Gene


Suggested Antigen Peptide Sequences for CPLX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complexin/synaphin family.
  • Belongs to the complexin/synaphin family.
genes like me logo Genes that share domains with CPLX3: view

No data available for Gene Families for CPLX3 Gene

Function for CPLX3 Gene

Molecular function for CPLX3 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates a late step in synaptic vesicle exocytosis.

Phenotypes for CPLX3 Gene

genes like me logo Genes that share phenotypes with CPLX3: view

Animal Models for CPLX3 Gene

MGI Knock Outs for CPLX3:

Animal Model Products

miRNA for CPLX3 Gene

miRTarBase miRNAs that target CPLX3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPLX3 Gene

Localization for CPLX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX3 Gene

Membrane; Lipid-anchor. Cell junction, synapse. Note=Enriched at the synaptic terminal. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CPLX3 Gene COMPARTMENTS Subcellular localization image for CPLX3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CPLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CPLX3: view

Pathways & Interactions for CPLX3 Gene

SuperPathways for CPLX3 Gene

genes like me logo Genes that share pathways with CPLX3: view

Pathways by source for CPLX3 Gene

1 BioSystems pathway for CPLX3 Gene
1 KEGG pathway for CPLX3 Gene

Interacting Proteins for CPLX3 Gene

Gene Ontology (GO) - Biological Process for CPLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030073 insulin secretion IEA --
genes like me logo Genes that share ontologies with CPLX3: view

No data available for SIGNOR curated interactions for CPLX3 Gene

Drugs & Compounds for CPLX3 Gene

No Compound Related Data Available

Transcripts for CPLX3 Gene

mRNA/cDNA for CPLX3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPLX3 Gene

Complexin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX3 Gene

No ASD Table

Relevant External Links for CPLX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPLX3 Gene

mRNA expression in normal human tissues for CPLX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX3 Gene

This gene is overexpressed in Spleen (x13.5), Prostate (x11.4), Brain - Cerebellum (x7.1), Heart - Atrial Appendage (x6.8), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for CPLX3 Gene

This gene is overexpressed in Brain (53.2) and Retina (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPLX3 Gene

SOURCE GeneReport for Unigene cluster for CPLX3 Gene Hs.187694

genes like me logo Genes that share expression patterns with CPLX3: view

Protein tissue co-expression partners for CPLX3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPLX3 Gene

Orthologs for CPLX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPLX3 35
  • 93.67 (n)
  • 96.84 (a)
CPLX3 36
  • 97 (a)
(Canis familiaris)
Mammalia CPLX3 35
  • 91.77 (n)
  • 96.84 (a)
CPLX3 36
  • 97 (a)
(Mus musculus)
Mammalia Cplx3 35
  • 89.66 (n)
  • 95.57 (a)
Cplx3 16
Cplx3 36
  • 96 (a)
(Pan troglodytes)
Mammalia CPLX3 35
  • 99.16 (n)
  • 99.37 (a)
CPLX3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cplx3 35
  • 88.82 (n)
  • 95.57 (a)
(Monodelphis domestica)
Mammalia CPLX3 36
  • 89 (a)
(Gallus gallus)
Aves CPLX3 35
  • 76.43 (n)
  • 78.34 (a)
CPLX3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia CPLX3 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lman1l 35
  • 73.63 (n)
  • 79.75 (a)
(Danio rerio)
Actinopterygii cplx3b 35
  • 68.59 (n)
  • 67.31 (a)
cplx3a 36
  • 63 (a)
cplx3a 36
  • 63 (a)
cplx3b 36
  • 67 (a)
Species with no ortholog for CPLX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX3 Gene

Gene Tree for CPLX3 (if available)
Gene Tree for CPLX3 (if available)

Paralogs for CPLX3 Gene

Paralogs for CPLX3 Gene

(1) SIMAP similar genes for CPLX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPLX3: view

Variants for CPLX3 Gene

Sequence variations from dbSNP and Humsavar for CPLX3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs79269642 -- 74,830,720(+) ACAGA(C/T)ACATC utr-variant-3-prime
rs3743487 -- 74,830,515(+) TCTTC(C/T)TCTCC utr-variant-3-prime
rs28681141 -- 74,830,574(+) ACCAG(A/C)TCAGC utr-variant-3-prime
rs140782445 -- 74,831,421(+) TCTGG(A/G)GCTTA utr-variant-3-prime
rs141104376 -- 74,830,466(+) CCTAG(C/T)TCCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CPLX3 Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
nsv520527 CNV Loss 19592680
nsv904381 CNV Loss 21882294

Variation tolerance for CPLX3 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPLX3 Gene

Disorders for CPLX3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPLX3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CPLX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPLX3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPLX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPLX3 Gene

Publications for CPLX3 Gene

  1. Structurally and functionally unique complexins at retinal ribbon synapses. (PMID: 15911881) Reim K. … Brose N. (J. Cell Biol. 2005) 2 3 4 67
  2. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PMID: 21876539) Amin N. … van Duijn C.M. (Mol. Psychiatry 2012) 3
  3. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis M.C. … Caporaso N.E. (PLoS Genet. 2011) 3
  4. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. (PMID: 21785413) Li F. … Rothman J.E. (Nat. Struct. Mol. Biol. 2011) 3
  5. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3

Products for CPLX3 Gene

Sources for CPLX3 Gene