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CPLX3 Gene

protein-coding   GIFtS: 46
GCID: GC15P075118

Complexin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complexin 31 2
Complexin III2 3
CPX III2 3
CPX-III2
CPXIII2
complexin-32

External Ids:    HGNC: 276521   Entrez Gene: 5948552   Ensembl: ENSG000002135787   OMIM: 6095855   UniProtKB: Q8WVH03   

Export aliases for CPLX3 gene to outside databases

Previous GC identifers: GC15U900493 GC15P072906 GC15P051915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CPLX3 Gene:
CPLX3 (complexin 3) is a protein-coding gene. Diseases associated with CPLX3 include hypoplastic left heart syndrome, and intestinal atresia. GO annotations related to this gene include neurotransmitter transporter activity and syntaxin binding. An important paralog of this gene is CPLX4.

UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0
Function: Positively regulates a late step in synaptic vesicle exocytosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPLX3 gene promoter:
         HOXA9   HOXA9B   Lmo2   CUTL1   Meis-1b   CP2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPLX3 promoter sequence
   Search Chromatin IP Primers for CPLX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPLX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CPLX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075118:  view genomic region     (about GC identifiers)

Start:
75,118,888 bp from pter      End:
75,124,141 bp from pter
Size:
5,254 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0 (See protein sequence)
Recommended Name: Complexin-3 precursor  
Size: 158 amino acids; 17557 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity)
Sequence caution: Sequence=BAB84922.1; Type=Erroneous initiation;
Secondary accessions: D3DW66 Q8TEM6 Q9H818

Explore the universe of human proteins at neXtProt for CPLX3: NX_Q8WVH0

Explore proteomics data for CPLX3 at MOPED

Post-translational modifications: 

  • Farnesylation mediates presynaptic targeting (By similarity)1
  • Modification sites at neXtProt

  • See CPLX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001025176.1  
    ENSEMBL proteins: 
     ENSP00000378464  

    CPLX3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for CPLX3
    Cloud-Clone Corp. CLIAs for CPLX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry Q8WVH0

    ProtoNet protein and cluster: Q8WVH0

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0
    Similarity: Belongs to the complexin/synaphin family


    CPLX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX3_HUMAN, Q8WVH0
    Function: Positively regulates a late step in synaptic vesicle exocytosis (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005326neurotransmitter transporter activity IEA--
    GO:0019905syntaxin binding IEA--
         
    CPLX3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cplx3):
     mortality/aging  nervous system  reproductive system  vision/eye 

    CPLX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cplx3tm1Rmnd for CPLX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPLX3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPLX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPLX3

    miRNA
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    Block miRNA regulation of human, mouse, rat CPLX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPLX3 (see all 16):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-148b hsa-miR-520a-5p hsa-miR-4267 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCPLX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPLX3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CPLX3 (NM_001030005)
    Sino Biological Human cDNA Clone for CPLX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPLX3_HUMAN, Q8WVH0: Membrane; Lipid-anchor. Cell junction, synapse (By similarity). Note=Enriched at the
    synaptic terminal (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    CPLX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPLX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPLX3
        Synaptic Vesicle Pathway



    1 Kegg Pathway  (Kegg details for CPLX3):
        Synaptic vesicle cycle


    CPLX3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPLX3
    Interactions:

        Search GeneGlobe Interaction Network for CPLX3

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0030073insulin secretion IEA--
    GO:0046928regulation of neurotransmitter secretion IEA--

    CPLX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPLX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPLX3 gene: 
    NM_001030005.2  

    Unigene Cluster for CPLX3:

    Complexin 3
    Hs.187694  [show with all ESTs]
    Unigene Representative Sequence: NM_001030005
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000395018
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPLX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPLX3 (see all 16):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-148b hsa-miR-520a-5p hsa-miR-4267 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCPLX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPLX3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPLX3
      QuantiTect SYBR Green Assays in human, mouse, rat CPLX3
      QuantiFast Probe-based Assays in human, mouse, rat CPLX3

    Additional mRNA sequence: 

    AB072900.1 AK024055.1 AY286501.1 BC018026.1 

    4 DOTS entries:

    DT.92419400  DT.75101138  DT.100802927  DT.100816374 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPLX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAAGGG
    CPLX3 Expression
    About this image


    CPLX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Midbrain   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Prostate (Endocrine System)
    CPLX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPLX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187694
        Custom PCR Arrays for CPLX3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CPLX3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx31 , 5 complexin 31, 5 89.66(n)1
    95.57(a)1
      9 (31.11 cM)5
    2354151  NM_146223.31  NP_666335.11 
     576000195 
    chicken
    (Gallus gallus)
    Aves CPLX31 complexin 3 76.43(n)
    78.34(a)
      769798  NM_001114505.1  NP_001107977.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPLX36
    complexin 3
    76(a)
    1 ↔ 1
    AAWZ02037818(1478-1713)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lman1l1 lectin, mannose-binding, 1 like 73.63(n)
    79.75(a)
      549251  NM_001016497.2  NP_001016497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cplx3b1 complexin 3b 68.59(n)
    67.31(a)
      794623  NM_001171590.1  NP_001165061.1 


    ENSEMBL Gene Tree for CPLX3 (if available)
    TreeFam Gene Tree for CPLX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPLX3 gene
    CPLX42  
    1 SIMAP similar gene for CPLX3 using alignment to 1 protein entry:     CPLX3_HUMAN:
    CPLX4

    CPLX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPLX3 (see all 118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481156701,2
    C,F--75119123(+) ATAAGG/AGAGAT 2 /R /G mis11Minor allele frequency- A:0.00NA 4492
    rs1995322601,2
    C--75119188(+) TATCAG/AAAGCA 2 /Q syn11Minor allele frequency- A:0.00EU 1135
    rs2014891261,2
    C--75119235(+) CTCCAA/G/TCGACC 1 -- int10--------
    rs801473551,2
    C,F--75119315(+) TACTTT/CCCTAG 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1878949651,2
    --75119339(+) CCGGGA/GGGTGT 1 -- int10--------
    rs46321131,2
    C,F,H--75119347(+) TGTCCT/CCTACA 1 -- int18Minor allele frequency- C:0.15NS NA CSA WA 914
    rs1469538931,2
    --75119438(+) GCGACC/TGGACG 1 -- int10--------
    rs1930423981,2
    --75119459(+) CGGAGC/TCTGGG 1 -- int10--------
    rs1379988081,2
    --75119533(+) AGCCGA/CCTATG 1 -- int10--------
    rs1160540211,2
    F--75119626(+) TGGGGG/ACACTC 1 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for CPLX3 (75118888 - 75124141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CPLX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520527CNV Loss19592680
    nsv904380CNV Loss21882294
    nsv904381CNV Loss21882294
    nsv833055CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609585    OMIM disorders: --

    8 diseases for CPLX3:    
    About MalaCards
    hypoplastic left heart syndrome    intestinal atresia    imperforate anus    neuroblastoma
    retinitis    hypertension    cerebritis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for CPLX3:
    Intestinal atresia     Imperforate anus     Hypoplastic left heart syndrome

    CPLX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPLX3

    Export disorders for CPLX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPLX3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CPLX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structurally and functionally unique complexins at retinal ribbon synapses. (PubMed id 15911881)1, 2, 3 Reim K.... Brose N. (J. Cell Biol. 2005)
    2. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1, 4 Amin N....van Duijn C.M. (Mol. Psychiatry 2012)
    3. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PubMed id 21490707)1, 4 Cornelis M.C....Caporaso N.E. (PLoS Genet. 2011)
    4. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. (PubMed id 21785413)1 Li F....Rothman J.E. (amp 2011)
    7. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)4 Levy D....van Duijn C.M. (Nat. Genet. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. (PubMed id 12934113)1 Ohira M....Nakagawara A. (Oncogene 2003)
    10. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 594855 HGNC: 27652 Ensembl:ENSG00000213578 euGenes: HUgn594855 ECgene: CPLX3 Kegg: 594855
    H-InvDB: CPLX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPLX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPLX3 gene:
    Search GeneIP for patents involving CPLX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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