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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPLX3 Gene

protein-coding   GIFtS: 46
GCID: GC15P075118

Complexin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complexin 31 2
Complexin III2 3
CPX III2 3
CPX-III2
CPXIII2
complexin-32

External Ids:    HGNC: 276521   Entrez Gene: 5948552   Ensembl: ENSG000002135787   OMIM: 6095855   UniProtKB: Q8WVH03   

Export aliases for CPLX3 gene to outside databases

Previous GC identifers: GC15U900493 GC15P072906 GC15P051915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CPLX3 Gene: 
CPLX3 (complexin 3) is a protein-coding gene. Diseases associated with CPLX3 include hypoplastic left heart syndrome, and imperforate anus, and among its related super-pathways are Synaptic Vesicle Pathway. GO annotations related to this gene include neurotransmitter transporter activity and syntaxin binding. An important paralog of this gene is CPLX4.

UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0
Function: Positively regulates a late step in synaptic vesicle exocytosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPLX3 gene promoter:
         HOXA9   HOXA9B   Lmo2   CUTL1   Meis-1b   CP2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPLX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPLX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPLX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CPLX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075118:  view genomic region     (about GC identifiers)

Start:
75,118,888 bp from pter      End:
75,124,141 bp from pter
Size:
5,254 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0 (See protein sequence)
Recommended Name: Complexin-3 precursor  
Size: 158 amino acids; 17557 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity)
Subcellular location: Membrane; Lipid-anchor. Cell junction, synapse (By similarity). Note=Enriched at the
synaptic terminal (By similarity)
Sequence caution: Sequence=BAB84922.1; Type=Erroneous initiation;
Secondary accessions: D3DW66 Q8TEM6 Q9H818

Explore the universe of human proteins at neXtProt for CPLX3: NX_Q8WVH0

Explore proteomics data for CPLX3 at MOPED 

Post-translational modifications:

  • UniProtKB: Farnesylation mediates presynaptic targeting (By similarity)
  • View neXtProt modification sites for NX_Q8WVH0

  • CPLX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPLX3 Protein Expression
    REFSEQ proteins: NP_001025176.1  
    ENSEMBL proteins: 
     ENSP00000378464  

    Human Recombinant Protein Products for CPLX3: 
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    Novus Biologicals CPLX3 Lysate
    Sino Biological Recombinant Protein for CPLX3
    Sino Biological Cell Lysate for CPLX3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPLX3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    CPLX3 for ontologies           About GeneDecksing



    CPLX3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CPLX3 

    Assay Products for CPLX3: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPLX3 
    Cloud-Clone Corp. CLIAs for CPLX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry Q8WVH0

    ProtoNet protein and cluster: Q8WVH0

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX3_HUMAN, Q8WVH0
    Similarity: Belongs to the complexin/synaphin family


    CPLX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX3_HUMAN, Q8WVH0
    Function: Positively regulates a late step in synaptic vesicle exocytosis (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005326neurotransmitter transporter activity IEA--
    GO:0019905syntaxin binding IEA--
         
    CPLX3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cplx3):
     mortality/aging  nervous system  reproductive system  vision/eye 

    CPLX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cplx3tm1Rmnd for CPLX3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPLX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPLX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPLX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPLX3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPLX3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CPLX3 (see all 16):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-148b hsa-miR-520a-5p hsa-miR-4267 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCPLX3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for CPLX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPLX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPLX3
    Sirion Biotech Customized adenovirus for overexpression of CPLX3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CPLX3 (see all 7)
    OriGene ORF clones in mouse, rat for CPLX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPLX3 (NM_001030005)
    Sino Biological Human cDNA Clone for CPLX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX3
    Sirion Biotech Customized lentivirus for stable overexpression of CPLX3 
                         Customized lentivirus expression plasmids for stable overexpression of CPLX3 

    Cell Line
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    Search LifeMap BioReagents cell lines for CPLX3
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPLX3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPLX3
        Synaptic Vesicle Pathway



    1         Kegg Pathway  (Kegg details for CPLX3):
        Synaptic vesicle cycle


    CPLX3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPLX3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0030073insulin secretion IEA--
    GO:0046928regulation of neurotransmitter secretion IEA--

    CPLX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPLX3

    Search CenterWatch for drugs/clinical trials and news about CPLX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPLX3 gene: 
    NM_001030005.2  

    Unigene Cluster for CPLX3:

    Complexin 3
    Hs.187694  [show with all ESTs]
    Unigene Representative Sequence: NM_001030005
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000395018
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPLX3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CPLX3 (see all 16):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-148b hsa-miR-520a-5p hsa-miR-4267 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCPLX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPLX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPLX3
    Clone
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    OriGene clones in human, mouse for CPLX3 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPLX3 (NM_001030005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX3
    Sirion Biotech Customized lentivirus for stable overexpression of CPLX3 
                         Customized lentivirus expression plasmids for stable overexpression of CPLX3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPLX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPLX3

    Additional mRNA sequence: 

    AB072900.1 AK024055.1 AY286501.1 BC018026.1 

    4 DOTS entries:

    DT.92419400  DT.75101138  DT.100802927  DT.100816374 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPLX3 expression in normal human tissues (normalized intensities)      CPLX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAAGGG
    CPLX3 Expression
    About this image


    CPLX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Midbrain   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Rod Bipolar Cells Inner Nuclear Layer
             Retina
             retina   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Spinal Cord (Nervous System)
             Ventral Horn   
     
     Prostate (Endocrine System)

    See CPLX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPLX3

    SOURCE GeneReport for Unigene cluster: Hs.187694
        SABiosciences Custom PCR Arrays for CPLX3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CPLX3 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx31 , 5 complexin 31, 5 89.66(n)1
    95.57(a)1
      9 (31.11 cM)5
    2354151  NM_146223.31  NP_666335.11 
     576000195 
    chicken
    (Gallus gallus)
    Aves CPLX31 complexin 3 77.92(n)
    80.25(a)
      769798  NM_001114505.1  NP_001107977.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPLX36
    Uncharacterized protein
    76(a)
    1 ↔ 1
    AAWZ02037818(1478-1713)
    zebrafish
    (Danio rerio)
    Actinopterygii cplx3b1 complexin 3b 69.87(n)
    69.23(a)
      794623  NM_001171590.1  NP_001165061.1 


    ENSEMBL Gene Tree for CPLX3 (if available)
    TreeFam Gene Tree for CPLX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPLX3 gene
    CPLX42  
    1 SIMAP similar gene for CPLX3 using alignment to 1 protein entry:     CPLX3_HUMAN:
    CPLX4

    CPLX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 SNPs in CPLX3 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481156701,2
    C,F--75119123(+) ATAAGG/AGAGAT 2 /R /G mis11Minor allele frequency- A:0.00NA 4492
    rs1995322601,2
    C--75119188(+) TATCAG/AAAGCA 2 /Q syn11Minor allele frequency- A:0.00EU 1135
    rs2014891261,2
    C--75119235(+) CTCCAA/G/TCGACC 1 -- int10--------
    rs801473551,2
    C,F--75119315(+) TACTTT/CCCTAG 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1878949651,2
    --75119339(+) CCGGGA/GGGTGT 1 -- int10--------
    rs46321131,2
    C,F,H--75119347(+) TGTCCT/CCTACA 1 -- int18Minor allele frequency- C:0.15NS NA CSA WA 914
    rs1469538931,2
    --75119438(+) GCGACC/TGGACG 1 -- int10--------
    rs1930423981,2
    --75119459(+) CGGAGC/TCTGGG 1 -- int10--------
    rs1379988081,2
    --75119533(+) AGCCGA/CCTATG 1 -- int10--------
    rs1160540211,2
    F--75119626(+) TGGGGG/ACACTC 1 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for CPLX3 (75118888 - 75124141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CPLX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520527CNV Loss19592680
    nsv904380CNV Loss21882294
    nsv904381CNV Loss21882294
    nsv833055CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPLX3
    DNA2.0 Custom Variant and Variant Library Synthesis for CPLX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609585    OMIM disorders: --

    4 diseases for CPLX3:    About MalaCards
    hypoplastic left heart syndrome    imperforate anus    neuroblastoma    retinitis

    3 diseases from the University of Copenhagen DISEASES database for CPLX3:
    Intestinal atresia     Imperforate anus     Hypoplastic left heart syndrome

    CPLX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPLX3

    Export disorders for CPLX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPLX3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CPLX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structurally and functionally unique complexins at retinal ribbon synapses. (PubMed id 15911881)1, 2, 3 Reim K.... Brose N. (2005)
    2. Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1, 4 Amin N....van Duijn C.M. (2012)
    3. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PubMed id 21490707)1, 4 Cornelis M.C....Caporaso N.E. (2011)
    4. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. (PubMed id 21785413)1 Li F....Rothman J.E. (2011)
    7. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)4 Levy D....van Duijn C.M. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. (PubMed id 12934113)1 Ohira M....Nakagawara A. (2003)
    10. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 594855 HGNC: 27652 Ensembl:ENSG00000213578 euGenes: HUgn594855 ECgene: CPLX3 Kegg: 594855
    H-InvDB: CPLX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPLX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPLX3 gene:
    Search GeneIP for patents involving CPLX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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