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Aliases for CPLX2 Gene

Aliases for CPLX2 Gene

  • Complexin 2 2 3
  • Complexin II 3 4
  • Synaphin-1 3 4
  • CPX II 3 4
  • CPX2 3 6
  • Complexin-2 3
  • Synaphin 1 3
  • 921-L 3
  • CPX-2 3
  • Hfb1 3

External Ids for CPLX2 Gene

Summaries for CPLX2 Gene

Entrez Gene Summary for CPLX2 Gene

  • Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPLX2 Gene

CPLX2 (Complexin 2) is a Protein Coding gene. Diseases associated with CPLX2 include schizophrenia. Among its related pathways are Synaptic vesicle cycle and Synaptic vesicle cycle. GO annotations related to this gene include syntaxin-1 binding. An important paralog of this gene is CPLX1.

UniProtKB/Swiss-Prot for CPLX2 Gene

  • Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).

Gene Wiki entry for CPLX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX2 Gene

Genomics for CPLX2 Gene

Genomic Location for CPLX2 Gene

175,796,310 bp from pter
175,884,021 bp from pter
87,712 bases
Plus strand

Genomic View for CPLX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPLX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX2 Gene

Regulatory Elements for CPLX2 Gene

Proteins for CPLX2 Gene

  • Protein details for CPLX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RAG2
    • O09056
    • Q13329
    • Q28184
    • Q52M15
    • Q64386

    Protein attributes for CPLX2 Gene

    134 amino acids
    Molecular mass:
    15394 Da
    Quaternary structure:
    • Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

neXtProt entry for CPLX2 Gene

Proteomics data for CPLX2 Gene at MOPED

Post-translational modifications for CPLX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPLX2 Gene

Domains for CPLX2 Gene

Protein Domains for CPLX2 Gene


Suggested Antigen Peptide Sequences for CPLX2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complexin/synaphin family.:
    • Q6PUV4
genes like me logo Genes that share domains with CPLX2: view

No data available for Gene Families for CPLX2 Gene

Function for CPLX2 Gene

Molecular function for CPLX2 Gene

GENATLAS Biochemistry: complexin 2,ubiquitously expressed at low levels,enriched in serum and colocalyzing with syntaxin and SNAP25,binding and potentially regulating the SNAP receptor core complex
UniProtKB/Swiss-Prot Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for CPLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0017075 syntaxin-1 binding IEA --
GO:0019905 syntaxin binding --
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with CPLX2: view
genes like me logo Genes that share phenotypes with CPLX2: view

Animal Models for CPLX2 Gene

MGI Knock Outs for CPLX2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CPLX2 Gene

Localization for CPLX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX2 Gene

Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CPLX2 Gene COMPARTMENTS Subcellular localization image for CPLX2 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CPLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030425 dendrite IEA --
GO:0031201 SNARE complex --
GO:0042629 mast cell granule IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CPLX2: view

Pathways for CPLX2 Gene

SuperPathways for CPLX2 Gene

genes like me logo Genes that share pathways with CPLX2: view

Pathways by source for CPLX2 Gene

1 BioSystems pathway for CPLX2 Gene
1 KEGG pathway for CPLX2 Gene

Gene Ontology (GO) - Biological Process for CPLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport --
GO:0006904 vesicle docking involved in exocytosis TAS 7553862
GO:0007399 nervous system development IEA --
GO:0016079 synaptic vesicle exocytosis IEA --
GO:0017157 regulation of exocytosis TAS 15217342
genes like me logo Genes that share ontologies with CPLX2: view

Transcripts for CPLX2 Gene

Unigene Clusters for CPLX2 Gene

Complexin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - - -
SP3: - -

Relevant External Links for CPLX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPLX2 Gene

mRNA expression in normal human tissues for CPLX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX2 Gene

This gene is overexpressed in Brain - Hippocampus (6.7), Brain - Amygdala (6.4), Brain - Cerebellar Hemisphere (5.8), Brain - Cortex (5.4), Brain - Frontal Cortex (BA9) (5.3), and Brain - Cerebellum (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPLX2 Gene

SOURCE GeneReport for Unigene cluster for CPLX2 Gene Hs.193235

mRNA Expression by UniProt/SwissProt for CPLX2 Gene

Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
genes like me logo Genes that share expressions with CPLX2: view

Orthologs for CPLX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPLX2 35
  • 98.94 (n)
  • 99.21 (a)
CPLX2 36
  • 100 (a)
(Bos Taurus)
Mammalia CPLX2 35
  • 94.28 (n)
  • 100 (a)
CPLX2 36
  • 100 (a)
(Canis familiaris)
Mammalia CPLX2 35
  • 93.53 (n)
  • 100 (a)
CPLX2 36
  • 100 (a)
(Mus musculus)
Mammalia Cplx2 35
  • 92.79 (n)
  • 100 (a)
Cplx2 16
Cplx2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia CPLX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cplx2 35
  • 92.04 (n)
  • 100 (a)
(Gallus gallus)
Aves CPLX2 36
  • 100 (a)
LOC100857281 35
  • 89.8 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68923 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cplx2 35
  • 80.1 (n)
  • 97.01 (a)
Str.15513 35
(Danio rerio)
Actinopterygii cplx2 35
  • 81.59 (n)
  • 94.03 (a)
cplx2 36
  • 94 (a)
Species with no ortholog for CPLX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX2 Gene

Gene Tree for CPLX2 (if available)
Gene Tree for CPLX2 (if available)

Paralogs for CPLX2 Gene

Paralogs for CPLX2 Gene

Selected SIMAP similar genes for CPLX2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPLX2: view

Variants for CPLX2 Gene

Sequence variations from dbSNP and Humsavar for CPLX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs871853 -- 175,855,307(+) TATAA(G/T)ACACC intron-variant
rs878850 -- 175,858,928(+) GATAG(C/T)CCGAA intron-variant
rs879483 -- 175,853,108(-) ACTTG(C/T)TATTA intron-variant
rs883019 -- 175,830,210(-) CCAGG(C/G)CAGCT intron-variant
rs883188 -- 175,824,575(-) AAGTT(A/C)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPLX2 Gene

Variant ID Type Subtype PubMed ID
nsv883121 CNV Gain 21882294
esv2663183 CNV Deletion 23128226
nsv462538 CNV Loss 19166990

Relevant External Links for CPLX2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPLX2 Gene

Disorders for CPLX2 Gene

(1) MalaCards Diseases for CPLX2 Gene

Search for CPLX2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CPLX2 Gene

(1) Novoseek inferred disease relationships for CPLX2 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 23.9 7

Relevant External Links for CPLX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CPLX2: view

No data available for UniProtKB/Swiss-Prot for CPLX2 Gene

Publications for CPLX2 Gene

  1. Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity. (PMID: 16162394) Raevskaya N.M. … Limborska S.A. (Gene 2005) 2 3 4 23
  2. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PMID: 16442780) Kishi T. … Iwata N. (Schizophr. Res. 2006) 3 23 48
  3. Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements. (PMID: 15906159) DiProspero N.A. … Tagle D.A. (J. Neurocytol. 2004) 3 4 23
  4. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PMID: 16131404) Lee H.J. … Fukumaki Y. (Behav Brain Funct 2005) 3 23 48
  5. Complexins: cytosolic proteins that regulate SNAP receptor function. (PMID: 7553862) McMahon H.T. … Suedhof T.C. (Cell 1995) 2 3 4

Products for CPLX2 Gene

Sources for CPLX2 Gene

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