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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPLX2 Gene

protein-coding   GIFtS: 61
GCID: GC05P175156

Complexin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complexin 21 2     Hfb12
Complexin II2 3     complexin-22
CPX II2 3     Synaphin 12
CPX22 5     synaphin-12
921-L2     Synaphin-13
CPX-22     

External Ids:    HGNC: 23101   Entrez Gene: 108142   Ensembl: ENSG000001459207   OMIM: 6050335   UniProtKB: Q6PUV43   

Export aliases for CPLX2 gene to outside databases

Previous GC identifers: GC05P175537 GC05P176044 GC05P175159 GC05P175204 GC05P170322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPLX2 Gene:
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle
exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to
the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPLX2 Gene: 
CPLX2 (complexin 2) is a protein-coding gene. Diseases associated with CPLX2 include mood disorder, and schizophrenia, and among its related super-pathways are Synaptic Vesicle Pathway. GO annotations related to this gene include syntaxin-1 binding. An important paralog of this gene is CPLX1.

UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic
membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved
in mast cell exocytosis (By similarity)

Gene Wiki entry for CPLX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPLX2 gene promoter:
         AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPLX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPLX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

CPLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175156:  view genomic region     (about GC identifiers)

Start:
175,223,313 bp from pter      End:
175,311,023 bp from pter
Size:
87,711 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4 (See protein sequence)
Recommended Name: Complexin-2  
Size: 134 amino acids; 15394 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity)
Subcellular location: Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons (By
similarity)
Secondary accessions: B2RAG2 O09056 Q13329 Q28184 Q52M15 Q64386

Explore the universe of human proteins at neXtProt for CPLX2: NX_Q6PUV4

Explore proteomics data for CPLX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PUV4

  • CPLX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPLX2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008221.1  NP_006641.1  

    ENSEMBL proteins: 
     ENSP00000352544   ENSP00000423564   ENSP00000421106   ENSP00000377346   ENSP00000425973  
     ENSP00000423612   ENSP00000424305   ENSP00000425284   ENSP00000421825  

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    Sino Biological Recombinant Protein for CPLX2
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPLX2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0030425dendrite IEA--
    GO:0031201SNARE complex IEA--
    GO:0043025neuronal cell body IEA--
    GO:0045202synapse IEA--

    CPLX2 for ontologies           About GeneDecksing



    CPLX2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry Q6PUV4

    ProtoNet protein and cluster: Q6PUV4

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
    Similarity: Belongs to the complexin/synaphin family


    CPLX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX2_HUMAN, Q6PUV4
    Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic
    membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved
    in mast cell exocytosis (By similarity)

         Genatlas biochemistry entry for CPLX2:
    complexin 2,ubiquitously expressed at low levels,enriched in serum and colocalyzing with syntaxin and
    SNAP25,binding and potentially regulating the SNAP receptor core complex

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding ----
         
    CPLX2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cplx2):
     behavior/neurological  mortality/aging  nervous system  reproductive system 

    CPLX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CPLX2: Cplx2tm1Rmnd Cplx2tm1Tyag

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPLX2 
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    SwitchGear 3'UTR luciferase reporter plasmidCPLX2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPLX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    2Selected targets of GCR-alpha
    Selected targets of GCR-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CPLX2
        Selected targets of GCR-alpha


    1 BioSystems Pathway for CPLX2
        Synaptic Vesicle Pathway



    1         Kegg Pathway  (Kegg details for CPLX2):
        Synaptic vesicle cycle


    CPLX2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/23 Interacting proteins for CPLX2 (Q6PUV43 ENSP000003525444) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    STX3Q132773, ENSP000003385624I2D: score=1 STRING: ENSP00000338562
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    ETS1P149213I2D: score=1 
    PCBD1P614573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0006904vesicle docking involved in exocytosis TAS7553862
    GO:0007399nervous system development IEA--
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0030154cell differentiation IEA--

    CPLX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPLX2

    Search CenterWatch for drugs/clinical trials and news about CPLX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPLX2 gene (2 alternative transcripts): 
    NM_001008220.1  NM_006650.3  

    Unigene Cluster for CPLX2:

    Complexin 2
    Hs.193235  [show with all ESTs]
    Unigene Representative Sequence: NM_006650
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359546(uc003mde.1 uc003mdf.1) ENST00000506642 ENST00000515502
    ENST00000509837 ENST00000393745 ENST00000512824 ENST00000514150 ENST00000502265
    ENST00000515025 ENST00000515094
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    8/119 QIAGEN miScript miRNA Assays for microRNAs that regulate CPLX2 (see all 119):
    hsa-miR-194* hsa-miR-548j hsa-miR-631 hsa-miR-1914* hsa-miR-218-1* hsa-miR-485-3p hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCPLX2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPLX2
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    Additional mRNA sequence: 

    AK055043.1 AK094266.1 AK124837.1 AK126590.1 AK293819.1 AK314177.1 AL512758.1 AY576870.1 
    BC039560.1 BC052974.1 BC065485.1 BC093706.1 BC112287.1 BC128413.1 U35100.1 Y15167.1 

    14 DOTS entries:

    DT.455059  DT.99966119  DT.95094911  DT.100031967  DT.120852880  DT.40120193  DT.120852856  DT.120852890 
    DT.120852891  DT.100787550  DT.120852866  DT.120852898  DT.75101500  DT.100787548 

    24/162 AceView cDNA sequences (see all 162):

    CB153756 T31067 Z42213 AA325350 AI497930 CB144313 AY576870 BE265409 
    BQ932801 CB155886 CB152078 AK055043 AL118919 BQ953624 AK124837 BQ881354 
    BM716283 BQ647098 BM006201 CB152324 AL119131 BM695061 AK094266 NM_032282 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CPLX2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -     -     -                       -               
    SP2:                    -     -     -     -     -                                       
    SP3:                                            -                       -               
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CPLX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPLX2 expression in normal human tissues (normalized intensities)      CPLX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACAAAGA
    CPLX2 Expression
    About this image


    CPLX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Brain (Nervous System)

    See CPLX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPLX2

    SOURCE GeneReport for Unigene cluster: Hs.193235

    UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
    Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons.
    Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major
    depression. Down-regulated in cerebellum from patients with schizophrenia

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPLX2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx21 , 5 complexin 21, 5 92.79(n)1
    100(a)1
      13 (28.59 cM)5
    128901  NM_009946.21  NP_034076.11 
     543713495 
    chicken
    (Gallus gallus)
    Aves LOC1008572811 complexin-2-like 89.8(n)
    100(a)
      100857281  XM_003642055.1  XP_003642103.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689232 hypothetical protein MGC68923 80.29(n)    BC059299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cplx21 complexin 2 81.59(n)
    94.03(a)
      556701  NM_001199318.1  NP_001186247.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cpx6
    complexin
    33(a)
    1 → many
    3R(105906-130349)
    worm
    (Caenorhabditis elegans)
    Secernentea cpx-16
    Putative complexin-1
    31(a)
    1 → many
    I(1594656-1596175)


    ENSEMBL Gene Tree for CPLX2 (if available)
    TreeFam Gene Tree for CPLX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPLX2 gene
    CPLX12  
    1 SIMAP similar gene for CPLX2 using alignment to 7 protein entries:     CPLX2_HUMAN (see all proteins):
    CPLX1

    CPLX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1705 SNPs in CPLX2 are shown (see all 1705)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs623871061,2
    C,F--170395163(+) TATTCG/ACCAGT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1465902721,2
    --170395274(+) CAGCCA/TCCCAC 1 -- us2k10--------
    rs562795131,2
    C--170395305(+) ATAGAG/AAACCC 1 -- us2k14Minor allele frequency- A:0.14WA NA EA 360
    rs1412851351,2
    C--170395337(+) TATCCC/TATGGC 1 -- us2k10--------
    rs24342391,2
    C,F,A--175221644(-) TGACAA/GCCTTA 1 -- us2k1 tfbs33Minor allele frequency- G:0.16WA NA EA 358
    rs757175591,2
    F--175221698(+) TGTGTA/GGGAGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs24435401,2
    C,F,A--175221857(+) CATTCG/ATAGAT 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358
    rs1932691751,2
    --175221964(+) TTCTCA/TCAGAA 1 -- us2k10--------
    rs24435411,2
    C,F,A,H--175221988(+) GAACAC/TTGCAG 1 -- us2k125Minor allele frequency- T:0.15NS EA NA WA 3186
    rs738030491,2
    C,F--175222028(+) GTTGCG/ATTTGA 1 -- us2k13Minor allele frequency- A:0.06WA CSA 122

    HapMap Linkage Disequilibrium report for CPLX2 (175223313 - 175311023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPLX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663183CNV Deletion23128226
    nsv462538CNV Loss19166990
    nsv883121CNV Gain21882294


    Human Gene Mutation Database (HGMD): CPLX2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605033    OMIM disorders: --

    5 diseases for CPLX2:    About MalaCards
    mood disorder    schizophrenia    bipolar disorder    huntington's disease
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CPLX2:
    Schizophrenia     Huntington's disease

    CPLX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CPLX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 23.9 8 16131404 (6), 16442780 (1)

    Genetic Association Database (GAD): CPLX2
    Human Genome Epidemiology (HuGE) Navigator: CPLX2 (8 documents)

    Export disorders for CPLX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPLX2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CPLX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity. (PubMed id 16162394)1, 2, 3, 9 Raevskaya N.M.... Limborska S.A. (2005)
    2. Complexins: cytosolic proteins that regulate SNAP receptor function. (PubMed id 7553862)1, 2, 3 McMahon H.T.... Suedhof T.C. (1995)
    3. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PubMed id 16131404)1, 4, 9 Lee H.J....Fukumaki Y. (2005)
    4. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PubMed id 16442780)1, 4, 9 Kishi T....Iwata N. (2006)
    5. Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements. (PubMed id 15906159)1, 2, 9 DiProspero N.A....Tagle D.A. (2004)
    6. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    7. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10814 HGNC: 2310 AceView: CPLX2andDKFZp547D155 Ensembl:ENSG00000145920 euGenes: HUgn10814
    ECgene: CPLX2 Kegg: 10814 H-InvDB: CPLX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPLX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPLX2 gene:
    Search GeneIP for patents involving CPLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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