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CPLX2 Gene

protein-coding   GIFtS: 61
GCID: GC05P175156

Complexin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complexin 21 2     Hfb12
Complexin II2 3     complexin-22
CPX II2 3     Synaphin 12
CPX22 5     synaphin-12
921-L2     Synaphin-13
CPX-22     

External Ids:    HGNC: 23101   Entrez Gene: 108142   Ensembl: ENSG000001459207   OMIM: 6050335   UniProtKB: Q6PUV43   

Export aliases for CPLX2 gene to outside databases

Previous GC identifers: GC05P175537 GC05P176044 GC05P175159 GC05P175204 GC05P170322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPLX2 Gene:
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle
exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to
the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPLX2 Gene:
CPLX2 (complexin 2) is a protein-coding gene. Diseases associated with CPLX2 include mood disorder, and schizophrenia. GO annotations related to this gene include syntaxin-1 binding. An important paralog of this gene is CPLX1.

UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic
membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved
in mast cell exocytosis (By similarity)

Gene Wiki entry for CPLX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPLX2 gene promoter:
         AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPLX2 promoter sequence
   Search Chromatin IP Primers for CPLX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

CPLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175156:  view genomic region     (about GC identifiers)

Start:
175,223,313 bp from pter      End:
175,311,023 bp from pter
Size:
87,711 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4 (See protein sequence)
Recommended Name: Complexin-2  
Size: 134 amino acids; 15394 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity)
Secondary accessions: B2RAG2 O09056 Q13329 Q28184 Q52M15 Q64386

Explore the universe of human proteins at neXtProt for CPLX2: NX_Q6PUV4

Explore proteomics data for CPLX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPLX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008221.1  NP_006641.1  

    ENSEMBL proteins: 
     ENSP00000352544   ENSP00000423564   ENSP00000421106   ENSP00000377346   ENSP00000425973  
     ENSP00000423612   ENSP00000424305   ENSP00000425284   ENSP00000421825  

    CPLX2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPLX2

    CPLX2 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CPLX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry Q6PUV4

    ProtoNet protein and cluster: Q6PUV4

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
    Similarity: Belongs to the complexin/synaphin family


    CPLX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX2_HUMAN, Q6PUV4
    Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic
    membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved
    in mast cell exocytosis (By similarity)

         Genatlas biochemistry entry for CPLX2:
    complexin 2,ubiquitously expressed at low levels,enriched in serum and colocalyzing with syntaxin and
    SNAP25,binding and potentially regulating the SNAP receptor core complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding ----
    GO:0048306calcium-dependent protein binding IEA--
         
    CPLX2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cplx2):
     behavior/neurological  mortality/aging  nervous system  reproductive system 

    CPLX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CPLX2: Cplx2tm1Rmnd Cplx2tm1Tyag

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPLX2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPLX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPLX2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CPLX2 (see all 119):
    hsa-miR-194* hsa-miR-548j hsa-miR-631 hsa-miR-1914* hsa-miR-218-1* hsa-miR-485-3p hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCPLX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CPLX2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CPLX2 (NM_006650)
    Sino Biological Human cDNA Clone for CPLX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPLX2_HUMAN, Q6PUV4: Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0030425dendrite IEA--
    GO:0031201SNARE complex ----
    GO:0042629mast cell granule IEA--
    GO:0043025neuronal cell body IEA--

    CPLX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPLX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Selected targets of GCR alpha
    Selected targets of GCR alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPLX2
        Synaptic Vesicle Pathway



    1 Kegg Pathway  (Kegg details for CPLX2):
        Synaptic vesicle cycle


    CPLX2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPLX2
    Interactions:

        GeneGlobe Interaction Network for CPLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CPLX2 (Q6PUV43 ENSP000003525444) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    STX3Q132773, ENSP000003385624I2D: score=1 STRING: ENSP00000338562
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    ETS1P149213I2D: score=1 
    PCBD1P614573I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0006904vesicle docking involved in exocytosis TAS7553862
    GO:0007399nervous system development IEA--
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0030154cell differentiation IEA--

    CPLX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPLX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CPLX2 gene (2 alternative transcripts): 
    NM_001008220.1  NM_006650.3  

    Unigene Cluster for CPLX2:

    Complexin 2
    Hs.193235  [show with all ESTs]
    Unigene Representative Sequence: NM_006650
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359546(uc003mde.1 uc003mdf.1) ENST00000506642 ENST00000515502
    ENST00000509837 ENST00000393745 ENST00000512824 ENST00000514150 ENST00000502265
    ENST00000515025 ENST00000515094
    miRNA
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    Block miRNA regulation of human, mouse, rat CPLX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPLX2 (see all 119):
    hsa-miR-194* hsa-miR-548j hsa-miR-631 hsa-miR-1914* hsa-miR-218-1* hsa-miR-485-3p hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCPLX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CPLX2
    Predesigned siRNA for gene silencing in human, mouse, rat CPLX2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPLX2 (NM_006650)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CPLX2
      QuantiFast Probe-based Assays in human, mouse, rat CPLX2

    Additional mRNA sequence: 

    AK055043.1 AK094266.1 AK124837.1 AK126590.1 AK293819.1 AK314177.1 AL512758.1 AY576870.1 
    BC039560.1 BC052974.1 BC065485.1 BC093706.1 BC112287.1 BC128413.1 U35100.1 Y15167.1 

    14 DOTS entries:

    DT.455059  DT.99966119  DT.95094911  DT.100031967  DT.120852880  DT.40120193  DT.120852856  DT.120852890 
    DT.120852891  DT.100787550  DT.120852866  DT.120852898  DT.75101500  DT.100787548 

    Selected AceView cDNA sequences (see all 162):

    AI497930 Z42213 BE265409 AA325350 BQ953624 T31067 CB144313 CB153756 
    AK124837 AY576870 CB155886 AL118919 CB152078 BQ932801 AK055043 AK094266 
    BM921723 AL110442 BU192399 NM_006650 AW137533 BM695061 BE261726 BM716283 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CPLX2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -     -     -                       -               
    SP2:                    -     -     -     -     -                                       
    SP3:                                            -                       -               
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CPLX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPLX2 expression in normal human tissues (normalized intensities)      CPLX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACAAAGA
    CPLX2 Expression
    About this image


    CPLX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
    CPLX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPLX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193235

    UniProtKB/Swiss-Prot: CPLX2_HUMAN, Q6PUV4
    Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons.
    Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major
    depression. Down-regulated in cerebellum from patients with schizophrenia

        Custom PCR Arrays for CPLX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CPLX2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx21 , 5 complexin 21, 5 92.79(n)1
    100(a)1
      13 (28.59 cM)5
    128901  NM_009946.21  NP_034076.11 
     543713495 
    chicken
    (Gallus gallus)
    Aves LOC1008572811 complexin-2-like 89.8(n)
    100(a)
      100857281  XM_003642055.2  XP_003642103.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689232 hypothetical protein MGC68923 80.29(n)    BC059299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cplx21 complexin 2 81.59(n)
    94.03(a)
      556701  NM_001199318.1  NP_001186247.1 


    ENSEMBL Gene Tree for CPLX2 (if available)
    TreeFam Gene Tree for CPLX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPLX2 gene
    CPLX12  
    1 SIMAP similar gene for CPLX2 using alignment to 7 protein entries:     CPLX2_HUMAN (see all proteins):
    CPLX1

    CPLX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPLX2 (see all 1705)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs623871061,2
    C,F--170395163(+) TATTCG/ACCAGT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1465902721,2
    --170395274(+) CAGCCA/TCCCAC 1 -- us2k10--------
    rs562795131,2
    C--170395305(+) ATAGAG/AAACCC 1 -- us2k14Minor allele frequency- A:0.14WA NA EA 360
    rs1412851351,2
    C--170395337(+) TATCCC/TATGGC 1 -- us2k10--------
    rs24342391,2
    C,F,A--175221644(-) TGACAA/GCCTTA 1 -- us2k1 tfbs33Minor allele frequency- G:0.16WA NA EA 358
    rs757175591,2
    F--175221698(+) TGTGTA/GGGAGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs24435401,2
    C,F,A--175221857(+) CATTCG/ATAGAT 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358
    rs1932691751,2
    --175221964(+) TTCTCA/TCAGAA 1 -- us2k10--------
    rs24435411,2
    C,F,A,H--175221988(+) GAACAC/TTGCAG 1 -- us2k125Minor allele frequency- T:0.15NS EA NA WA 3186
    rs738030491,2
    C,F--175222028(+) GTTGCG/ATTTGA 1 -- us2k13Minor allele frequency- A:0.06WA CSA 122

    HapMap Linkage Disequilibrium report for CPLX2 (175223313 - 175311023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPLX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663183CNV Deletion23128226
    nsv462538CNV Loss19166990
    nsv883121CNV Gain21882294

    Human Gene Mutation Database (HGMD): CPLX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPLX2
    DNA2.0 Custom Variant and Variant Library Synthesis for CPLX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605033    OMIM disorders: --

    7 diseases for CPLX2:    About MalaCards
    mood disorder    schizophrenia    huntington's disease    bipolar disorder
    hypertension    obesity    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CPLX2:
    Schizophrenia     Huntington's disease

    CPLX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CPLX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 23.9 8 16131404 (6), 16442780 (1)

    Genetic Association Database (GAD): CPLX2
    Human Genome Epidemiology (HuGE) Navigator: CPLX2 (8 documents)

    Export disorders for CPLX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPLX2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CPLX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity. (PubMed id 16162394)1, 2, 3, 9 Raevskaya N.M.... Limborska S.A. (Gene 2005)
    2. Complexins: cytosolic proteins that regulate SNAP receptor function. (PubMed id 7553862)1, 2, 3 McMahon H.T.... Suedhof T.C. (Cell 1995)
    3. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PubMed id 16131404)1, 4, 9 Lee H.J....Fukumaki Y. (Behav Brain Funct 2005)
    4. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PubMed id 16442780)1, 4, 9 Kishi T....Iwata N. (Schizophr. Res. 2006)
    5. Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements. (PubMed id 15906159)1, 2, 9 DiProspero N.A....Tagle D.A. (J. Neurocytol. 2004)
    6. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    7. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10814 HGNC: 2310 AceView: CPLX2andDKFZp547D155 Ensembl:ENSG00000145920 euGenes: HUgn10814
    ECgene: CPLX2 Kegg: 10814 H-InvDB: CPLX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPLX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CPLX2 gene:
    Search GeneIP for patents involving CPLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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