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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPLX1 Gene

protein-coding   GIFtS: 62
GCID: GC04M000778

Complexin 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complexin 11 2     complexin-12
Complexin I2 3     Synaphin 22
CPX I2 3     synaphin-22
CPX12 5     Synaphin-23
CPX-I2     

External Ids:    HGNC: 23091   Entrez Gene: 108152   Ensembl: ENSG000001689937   OMIM: 6050325   UniProtKB: O148103   

Export aliases for CPLX1 gene to outside databases

Previous GC identifers: GC04M000804 GC04M000769 GC04M000770 GC04M000771 GC04M000749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPLX1 Gene:
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle
exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to
the SNAP receptor complex and disrupts it, allowing transmitter release. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPLX1 Gene: 
CPLX1 (complexin 1) is a protein-coding gene. Diseases associated with CPLX1 include wernicke encephalopathy, and parkinson's disease, and among its related super-pathways are Synaptic Vesicle Pathway and Serotonin Neurotransmitter Release Cycle. GO annotations related to this gene include neurotransmitter transporter activity and syntaxin-1 binding. An important paralog of this gene is CPLX2.

UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
Function: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a
cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with
fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the
synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity)

Gene Wiki entry for CPLX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_037622.5  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPLX1 gene promoter:
         Sp1   HTF   Egr-4   CREB   deltaCREB   Cart-1   Msx-1   Pax-4a   LyF-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CPLX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

CPLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000778:  view genomic region     (about GC identifiers)

Start:
778,745 bp from pter      End:
819,986 bp from pter
Size:
41,242 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810 (See protein sequence)
Recommended Name: Complexin-1  
Size: 134 amino acids; 15030 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A
Subcellular location: Cytoplasm, cytosol (By similarity). Note=Enriched at synaptic-releasing sites in mature
neurons (By similarity)
2 PDB 3D structures from and Proteopedia for CPLX1:
3RK3 (3D)        3RL0 (3D)    
Secondary accessions: A6NI80 B2R4R5 D3DVN3

Explore the universe of human proteins at neXtProt for CPLX1: NX_O14810

Explore proteomics data for CPLX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14810

  • CPLX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPLX1 Protein Expression
    REFSEQ proteins: NP_006642.1  
    ENSEMBL proteins: 
     ENSP00000305613   ENSP00000425960   ENSP00000421947  
    Reactome Protein details: O14810
    Human Recombinant Protein Products for CPLX1: 
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    ProSpec Recombinant Protein for CPLX1
    Cloud-Clone Corp. Proteins for CPLX1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--
    GO:0031201SNARE complex ----
    GO:0043025neuronal cell body IEA--
    GO:0043234protein complex ----

    CPLX1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry O14810

    ProtoNet protein and cluster: O14810

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
    Similarity: Belongs to the complexin/synaphin family


    CPLX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX1_HUMAN, O14810
    Function: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a
    cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with
    fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the
    synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005326neurotransmitter transporter activity IEA--
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding ----
         
    CPLX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPLX1:
     Decreased influenza A virus in 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cplx1):
     behavior/neurological  growth/size  hearing/vestibular/ear  mortality/aging  nervous system 
     reproductive system 

    CPLX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cplx1tm1Rmnd for CPLX1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPLX1 
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    SwitchGear 3'UTR luciferase reporter plasmidCPLX1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPLX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    2Serotonin Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.60
    Acetylcholine Neurotransmitter Release Cycle0.53
    Dopamine Neurotransmitter Release Cycle0.60
    Glutamate Neurotransmitter Release Cycle0.44
    Norepinephrine Neurotransmitter Release Cycle0.60
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    4GABA synthesis, release, reuptake and degradation
    GABA synthesis, release, reuptake and degradation0.53
    Neurotransmitter Release Cycle0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPLX1
        Synaptic Vesicle Pathway


    5/9        Reactome Pathways for CPLX1 (see all 9)
        Acetylcholine Neurotransmitter Release Cycle
    Transmission across Chemical Synapses
    GABA synthesis, release, reuptake and degradation
    Neurotransmitter Release Cycle
    Neuronal System


    1         Kegg Pathway  (Kegg details for CPLX1):
        Synaptic vesicle cycle


    CPLX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPLX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for CPLX1 (O148103 ENSP000003056134) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0006887exocytosis TAS7553862
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0014047glutamate secretion TAS--

    CPLX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPLX1

    Search CenterWatch for drugs/clinical trials and news about CPLX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPLX1 gene: 
    NM_006651.3  

    Unigene Cluster for CPLX1:

    Complexin 1
    Hs.478930  [show with all ESTs]
    Unigene Representative Sequence: NM_006651
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304062(uc003gbi.3 uc003gbj.3) ENST00000505203 ENST00000506404
    ENST00000504062

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    Additional mRNA sequence: 

    AB593095.1 AF022383.1 AK126578.1 AK311921.1 BC002471.2 BT007029.1 

    6 DOTS entries:

    DT.408291  DT.101980599  DT.100036075  DT.92065654  DT.40120035  DT.92422340 

    24/80 AceView cDNA sequences (see all 80):

    BQ130485 BM543581 AW296025 CB153682 BM716718 BU739726 AK126578 CK300528 
    BI489595 NM_006651 BM714837 AA323455 T34916 BE222735 BT007029 CR603035 
    AI886623 BC002471 BU952000 BM707217 BU187125 AW955150 BX446900 AI362937 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CPLX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                    -     -                           
    SP2:                    -     -                           
    SP3:                          -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for CPLX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPLX1 expression in normal human tissues (normalized intensities)      CPLX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGGCCCC
    CPLX1 Expression
    About this image


    CPLX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See CPLX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPLX1

    SOURCE GeneReport for Unigene cluster: Hs.478930

    UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
    Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons.
    Overexpressed in substantia nigra from patients with Parkinson disease

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPLX1 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx11 , 5 complexin 11, 5 87.06(n)1
    97.01(a)1
      5 (53.17 cM)5
    128891  NM_007756.31  NP_031782.31 
     1085185545 
    chicken
    (Gallus gallus)
    Aves CPLX21 complexin 2 79.85(n)
    91.79(a)
      427286  XM_424869.3  XP_424869.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPLX16
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343201.1(1682861-1908280)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc97e102 Transcribed sequence with moderate similarity to protein more 74.67(n)    CK363405.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cpx6
    complexin
    34(a)
    1 → many
    3R(105906-130349)
    worm
    (Caenorhabditis elegans)
    Secernentea cpx-16
    Putative complexin-1
    32(a)
    1 → many
    I(1594656-1596175)


    ENSEMBL Gene Tree for CPLX1 (if available)
    TreeFam Gene Tree for CPLX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPLX1 gene
    CPLX22  
    1 SIMAP similar gene for CPLX1 using alignment to 4 protein entries:     CPLX1_HUMAN (see all proteins):
    CPLX2

    CPLX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 SNPs in CPLX1 are shown (see all 952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38220271,2
    C,F,A--778275(+) CTGGGT/CTGGGG 1 -- ds50019Minor allele frequency- C:0.10EA NA WA CSA 1745
    rs37333561,2
    C,F,A--778376(+) GGGGTG/ACTGGG 1 -- ds50019Minor allele frequency- A:0.27NA WA CSA EA 368
    rs117344621,2
    C,H--778488(+) TCCTAG/TGTGGG 1 -- ds50014Minor allele frequency- T:0.00NS EA 404
    rs37333571,2
    C,F,A--778549(+) GCGGGA/GGACCC 1 -- ds50018Minor allele frequency- G:0.38NA WA CSA 249
    rs37333581,2
    C,F,H--778599(+) CTGGAC/TGGCCT 1 -- ds50018Minor allele frequency- T:0.13EA NS NA 2110
    rs1440304901,2
    C--778814(+) TGCAGA/GAGGAG 1 -- ut310--------
    rs1880136261,2
    --778910(+) CGCAGA/GTTCTA 1 -- ut310--------
    rs1464331461,2
    --778916(+) TTCTAC/TGAGAG 1 -- ut310--------
    rs1809253221,2
    --778973(+) AGTTTA/TTAAAA 1 -- ut310--------
    rs1397940781,2
    C--778981(+) AAAGAC/GACGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CPLX1 (778745 - 819986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/31 variations for CPLX1 (see all 31):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726712CNV Deletion23290073
    esv996415CNV Deletion20482838
    esv990610CNV Deletion20482838
    esv2726711CNV Deletion23290073
    esv2726713CNV Deletion23290073
    esv2661833CNV Deletion23128226
    esv2354094CNV Deletion18987734
    esv2726709CNV Deletion23290073
    esv2726710CNV Deletion23290073
    dgv5389n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605032    OMIM disorders: --

    5 diseases for CPLX1:    About MalaCards
    wernicke encephalopathy    parkinson's disease    schizophrenia    neuronitis
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for CPLX1:
    Wernicke encephalopathy     Schizophrenia

    CPLX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CPLX1
    Human Genome Epidemiology (HuGE) Navigator: CPLX1 (2 documents)

    Export disorders for CPLX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPLX1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CPLX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complexins: cytosolic proteins that regulate SNAP receptor function. (PubMed id 7553862)1, 2, 3 McMahon H.T.... Suedhof T.C. (1995)
    2. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PubMed id 16442780)1, 4, 9 Kishi T....Iwata N. (2006)
    3. Complexin cross-links prefusion SNAREs into a zigzag array. (PubMed id 21785414)1, 2 Kummel D.... Reinisch K.M. (2011)
    4. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    5. Proteome analysis of human substantia nigra in Parkinson's disease. (PubMed id 15526345)1, 2 Basso M....Fasano M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cerebellar synaptic protein expression in schizophrenia. (PubMed id 11483314)1, 2 Eastwood S.L.... Harrison P.J. (2001)
    8. Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. (PubMed id 9853440)1, 2 Harrison P.J. and Eastwood S.L. (1998)
    9. Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. (PubMed id 18240322)1, 9 Salimi K....Jarskog L.F. (2008)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10815 HGNC: 2309 AceView: CPLX1 Ensembl:ENSG00000168993 euGenes: HUgn10815
    ECgene: CPLX1 Kegg: 10815 H-InvDB: CPLX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPLX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPLX1 gene:
    Search GeneIP for patents involving CPLX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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