Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CPLX1 Gene

protein-coding   GIFtS: 62
GCID: GC04M000778

Complexin 1

  See CPLX1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Complexin 11 2     complexin-12
Complexin I2 3     Synaphin 22
CPX I2 3     synaphin-22
CPX12 5     Synaphin-23
CPX-I2     

External Ids:    HGNC: 23091   Entrez Gene: 108152   Ensembl: ENSG000001689937   OMIM: 6050325   UniProtKB: O148103   

Export aliases for CPLX1 gene to outside databases

Previous GC identifers: GC04M000804 GC04M000769 GC04M000770 GC04M000771 GC04M000749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CPLX1 Gene:
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle
exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to
the SNAP receptor complex and disrupts it, allowing transmitter release. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPLX1 Gene:
CPLX1 (complexin 1) is a protein-coding gene. Diseases associated with CPLX1 include wernicke encephalopathy. GO annotations related to this gene include neurotransmitter transporter activity and syntaxin-1 binding. An important paralog of this gene is CPLX2.

UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
Function: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a
cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with
fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the
synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity)

Gene Wiki entry for CPLX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPLX1 gene promoter:
         Sp1   HTF   Egr-4   CREB   deltaCREB   Cart-1   Msx-1   Pax-4a   LyF-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CPLX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

CPLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPLX1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M000778:  view genomic region     (about GC identifiers)

Start:
778,745 bp from pter      End:
819,986 bp from pter
Size:
41,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810 (See protein sequence)
Recommended Name: Complexin-1  
Size: 134 amino acids; 15030 Da
Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A
2 PDB 3D structures from and Proteopedia for CPLX1:
3RK3 (3D)        3RL0 (3D)    
Secondary accessions: A6NI80 B2R4R5 D3DVN3

Explore the universe of human proteins at neXtProt for CPLX1: NX_O14810

Explore proteomics data for CPLX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CPLX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006642.1  
    ENSEMBL proteins: 
     ENSP00000305613   ENSP00000425960   ENSP00000421947  
    Reactome Protein details: O14810

    CPLX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CPLX1
    OriGene Protein Over-expression Lysate for CPLX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CPLX1
    GenScript Custom Purified and Recombinant Proteins Services for CPLX1
    Novus Biologicals CPLX1 Proteins
    Novus Biologicals CPLX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CPLX1
    Cloud-Clone Corp. Proteins for CPLX1

     
    Search eBioscience for Proteins for CPLX1 

    CPLX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CPLX1
    R&D Systems Antibodies for CPLX1 (Complexin-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CPLX1
    Novus Biologicals CPLX1 Antibody
    Abcam antibodies for CPLX1
    Cloud-Clone Corp. Antibodies for CPLX1
    ThermoFisher Antibodies for CPLX1
    LSBio Antibodies in human, mouse, rat for CPLX1

    CPLX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CPLX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPLX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPLX1
    Cloud-Clone Corp. CLIAs for CPLX1
    Search eBioscience for ELISAs for CPLX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008849 Synaphin

    Graphical View of Domain Structure for InterPro Entry O14810

    ProtoNet protein and cluster: O14810

    1 Blocks protein domain: IPB008849 Synaphin

    UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
    Similarity: Belongs to the complexin/synaphin family


    Find genes that share domains with CPLX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPLX1_HUMAN, O14810
    Function: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a
    cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with
    fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the
    synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005326neurotransmitter transporter activity IEA--
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding ----
         
    Find genes that share ontologies with CPLX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CPLX1:
     Decreased influenza A virus in 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cplx1):
     behavior/neurological  growth/size/body  hearing/vestibular/ear  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with CPLX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cplx1tm1Rmnd for CPLX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPLX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPLX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPLX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPLX1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CPLX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPLX1 (see all 27):
    hsa-miR-185* hsa-miR-99b* hsa-miR-4272 hsa-miR-765 hsa-miR-25 hsa-miR-570 hsa-miR-421 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidCPLX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPLX1
    Predesigned siRNA for gene silencing in human, mouse, rat CPLX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPLX1

    Clone
    Products:
         
    OriGene clones in human, mouse for CPLX1 (see all 5)
    OriGene ORF clones in mouse, rat for CPLX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPLX1 (NM_006651)
    Sino Biological Human cDNA Clone for CPLX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CPLX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CPLX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CPLX1_HUMAN, O14810: Cytoplasm, cytosol (By similarity). Note=Enriched at synaptic-releasing sites in mature
    neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--
    GO:0031201SNARE complex ----
    GO:0043025neuronal cell body IEA--
    GO:0043234protein complex ----

    Find genes that share ontologies with CPLX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CPLX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.40
    Glutamate Neurotransmitter Release Cycle0.00
    Neurotransmitter Release Cycle0.32
    Dopamine Neurotransmitter Release Cycle0.00
    Acetylcholine Neurotransmitter Release Cycle0.00
    Norepinephrine Neurotransmitter Release Cycle0.00
    GABA synthesis, release, reuptake and degradation0.00
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68


    Find genes that share SuperPaths with CPLX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPLX1
        Synaptic Vesicle Pathway


    Selected Reactome Pathways for CPLX1 (see all 6)
        Acetylcholine Neurotransmitter Release Cycle
    Glutamate Neurotransmitter Release Cycle
    Norepinephrine Neurotransmitter Release Cycle
    Dopamine Neurotransmitter Release Cycle
    GABA synthesis, release, reuptake and degradation


    1 Kegg Pathway  (Kegg details for CPLX1):
        Synaptic vesicle cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPLX1
    Interactions:

        GeneGlobe Interaction Network for CPLX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CPLX1 (O148103 ENSP000003056134) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport ----
    GO:0006887exocytosis TAS7553862
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0014047glutamate secretion TAS--

    Find genes that share ontologies with CPLX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPLX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CPLX1 gene: 
    NM_006651.3  

    Unigene Cluster for CPLX1:

    Complexin 1
    Hs.478930  [show with all ESTs]
    Unigene Representative Sequence: NM_006651
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304062(uc003gbi.3 uc003gbj.3) ENST00000505203 ENST00000506404
    ENST00000504062
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPLX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPLX1 (see all 27):
    hsa-miR-185* hsa-miR-99b* hsa-miR-4272 hsa-miR-765 hsa-miR-25 hsa-miR-570 hsa-miR-421 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidCPLX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPLX1
    Predesigned siRNA for gene silencing in human, mouse, rat CPLX1
    Clone
    Products:
         
    OriGene clones in human, mouse for CPLX1 (see all 5)
    OriGene ORF clones in mouse, rat for CPLX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPLX1 (NM_006651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPLX1
    OriGene qSTAR qPCR primer pairs in human, mouse for CPLX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPLX1
      QuantiTect SYBR Green Assays in human, mouse, rat CPLX1
      QuantiFast Probe-based Assays in human, mouse, rat CPLX1

    Additional mRNA sequence: 

    AB593095.1 AF022383.1 AK126578.1 AK311921.1 BC002471.2 BT007029.1 

    6 DOTS entries:

    DT.408291  DT.101980599  DT.100036075  DT.92065654  DT.40120035  DT.92422340 

    Selected AceView cDNA sequences (see all 80):

    NM_006651 BU739726 AA323455 BM716718 BE222735 AK126578 AI886623 CR603035 
    T34916 BI489595 CB153682 BM714837 BT007029 BM543581 AW296025 BQ130485 
    CK300528 BM702265 BX446900 AF022383 BM932290 BU728350 AI933099 BM714464 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CPLX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                    -     -                           
    SP2:                    -     -                           
    SP3:                          -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for CPLX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CPLX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGGCCCC
    CPLX1 Expression
    About this image


    CPLX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    CPLX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPLX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.478930

    UniProtKB/Swiss-Prot: CPLX1_HUMAN, O14810
    Tissue specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons.
    Overexpressed in substantia nigra from patients with Parkinson disease

        Custom PCR Arrays for CPLX1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CPLX1
    OriGene qSTAR qPCR primer pairs in human, mouse for CPLX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPLX1
    QuantiTect SYBR Green Assays in human, mouse, rat CPLX1
    QuantiFast Probe-based Assays in human, mouse, rat CPLX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CPLX1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cplx11 , 5 complexin 11, 5 87.06(n)1
    97.01(a)1
      5 (53.17 cM)5
    128891  NM_007756.31  NP_031782.31 
     1085185545 
    chicken
    (Gallus gallus)
    Aves CPLX21 complexin 2 79.85(n)
    91.79(a)
      427286  XM_424869.4  XP_424869.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPLX16
    complexin 1
    93(a)
    1 ↔ 1
    GL343201.1(1682861-1908280)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cplx11 complexin 1 72.68(n)
    90.23(a)
      100124828  NM_001102793.1  NP_001096263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc97e102 Transcribed sequence with moderate similarity to protein more 74.67(n)    CK363405.1 


    ENSEMBL Gene Tree for CPLX1 (if available)
    TreeFam Gene Tree for CPLX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CPLX1 gene
    CPLX22  
    1 SIMAP similar gene for CPLX1 using alignment to 4 protein entries:     CPLX1_HUMAN (see all proteins):
    CPLX2

    Find genes that share paralogs with CPLX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CPLX1 (see all 952)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38220271,2
    C,F,A--778275(+) CTGGGT/CTGGGG 1 -- ds50019Minor allele frequency- C:0.10EA NA WA CSA 1745
    rs37333561,2
    C,F,A--778376(+) GGGGTG/ACTGGG 1 -- ds50019Minor allele frequency- A:0.27NA WA CSA EA 368
    rs117344621,2
    C,H--778488(+) TCCTAG/TGTGGG 1 -- ds50014Minor allele frequency- T:0.00NS EA 404
    rs37333571,2
    C,F,A--778549(+) GCGGGA/GGACCC 1 -- ds50018Minor allele frequency- G:0.38NA WA CSA 249
    rs37333581,2
    C,F,H--778599(+) CTGGAC/TGGCCT 1 -- ds50018Minor allele frequency- T:0.13EA NS NA 2110
    rs1440304901,2
    C--778814(+) TGCAGA/GAGGAG 1 -- ut310--------
    rs1880136261,2
    --778910(+) CGCAGA/GTTCTA 1 -- ut310--------
    rs1464331461,2
    --778916(+) TTCTAC/TGAGAG 1 -- ut310--------
    rs1809253221,2
    --778973(+) AGTTTA/TTAAAA 1 -- ut310--------
    rs1397940781,2
    C--778981(+) AAAGAC/GACGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CPLX1 (778745 - 819986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CPLX1 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726712CNV Deletion23290073
    esv996415CNV Deletion20482838
    esv990610CNV Deletion20482838
    esv2726711CNV Deletion23290073
    esv2726713CNV Deletion23290073
    esv2661833CNV Deletion23128226
    esv2354094CNV Deletion18987734
    esv2726709CNV Deletion23290073
    esv2726710CNV Deletion23290073
    dgv5389n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPLX1
    DNA2.0 Custom Variant and Variant Library Synthesis for CPLX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605032    OMIM disorders: --

    1 disease for CPLX1:    
    About MalaCards
    wernicke encephalopathy

    2 diseases from the University of Copenhagen DISEASES database for CPLX1:
    Wernicke encephalopathy     Schizophrenia

    Find genes that share disorders with CPLX1           About GenesLikeMe

    Genetic Association Database (GAD): CPLX1
    Human Genome Epidemiology (HuGE) Navigator: CPLX1 (2 documents)

    Export disorders for CPLX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CPLX1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CPLX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complexins: cytosolic proteins that regulate SNAP receptor function. (PubMed id 7553862)1, 2, 3 McMahon H.T.... Suedhof T.C. (Cell 1995)
    2. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. (PubMed id 16442780)1, 4, 9 Kishi T....Iwata N. (Schizophr. Res. 2006)
    3. Complexin cross-links prefusion SNAREs into a zigzag array. (PubMed id 21785414)1, 2 Kummel D.... Reinisch K.M. (Nat. Struct. Mol. Biol. 2011)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. Proteome analysis of human substantia nigra in Parkinson's disease. (PubMed id 15526345)1, 2 Basso M....Fasano M. (Proteomics 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cerebellar synaptic protein expression in schizophrenia. (PubMed id 11483314)1, 2 Eastwood S.L.... Harrison P.J. (Neuroscience 2001)
    8. Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. (PubMed id 9853440)1, 2 Harrison P.J. and Eastwood S.L. (Lancet 1998)
    9. Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. (PubMed id 18240322)1, 9 Salimi K....Jarskog L.F. (Synapse 2008)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10815 HGNC: 2309 AceView: CPLX1 Ensembl:ENSG00000168993 euGenes: HUgn10815
    ECgene: CPLX1 Kegg: 10815 H-InvDB: CPLX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CPLX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CPLX1 gene:
    Search GeneIP for patents involving CPLX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CPLX1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for CPLX1 (Complexin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CPLX1  
     OriGene qPCR primer pairs and template standards for CPLX1   OriGene Protein Over-expression Lysate for CPLX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CPLX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CPLX1   OriGene Purified Protein for CPLX1  
     OriGene ORF clones in mouse, rat for CPLX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CPLX1   OriGene Custom Protein Services for CPLX1  

     
     
     Block miRNA regulation of human, mouse, rat CPLX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CPLX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPLX1 Predesigned siRNA for gene silencing in human, mouse, rat CPLX1
     QuantiFast Probe-based Assays in human, mouse, rat CPLX1 QuantiTect SYBR Green Assays in human, mouse, rat CPLX1
     Custom PCR Arrays for CPLX1 Search Chromatin IP Primers for CPLX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPLX1  GeneGlobe Interaction Network for CPLX1
     Regulatory tfbs in CPLX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CPLX1 GenScript cDNA clones with any tag delivered in your preferred vector for CPLX1
     GenScript Custom Assay Services for CPLX1 GenScript Custom overexpressing Cell Line Services for CPLX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CPLX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CPLX1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CPLX1 antibodies
     CPLX1 proteins
     CPLX1 lysates
     Antibodies for CPLX1
     See all of Abcam's Antibodies, Kits and Proteins for CPLX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CPLX1
     Proteins for CPLX1
     Antibodies for CPLX1
     ELISAs for CPLX1
     CLIAs for CPLX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CPLX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPLX1
     SwitchGear 3'UTR luciferase reporter plasmids for CPLX1
     Browse SwitchGear Promoter luciferase reporter plasmids for CPLX1
     ThermoFisher Antibodies for CPLX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPLX1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPLX1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPLX1
     LSBio Antibodies in human, mouse, rat for CPLX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CPLX1
      Search eBioscience for proteins for CPLX1
      Search eBioscience for elisas for CPLX1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CPLX1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4