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Aliases for CPED1 Gene

Aliases for CPED1 Gene

  • Cadherin Like And PC-Esterase Domain Containing 1 2 3 5
  • C7orf58 3 4
  • Cadherin-Like And PC-Esterase Domain-Containing Protein 1 3
  • Cadherin-Like And PC-Esterase Domain Containing 1 2
  • Chromosome 7 Open Reading Frame 58 2

External Ids for CPED1 Gene

Previous HGNC Symbols for CPED1 Gene

  • C7orf58

Previous GeneCards Identifiers for CPED1 Gene

  • GC07P120629

Summaries for CPED1 Gene

GeneCards Summary for CPED1 Gene

CPED1 (Cadherin Like And PC-Esterase Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for CPED1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPED1 Gene

Genomics for CPED1 Gene

Regulatory Elements for CPED1 Gene

Enhancers for CPED1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F121081 1.6 FANTOM5 Ensembl ENCODE 35.8 +95.9 95930 6.3 HDGF HDAC1 ATF1 PKNOX1 ARNT SIN3A NFXL1 ZNF2 RAD21 RFX5 CPED1 ING3 RNA5SP241 GC07M121084 GC07P121089
GH07F121041 1.2 Ensembl ENCODE 12 +53.3 53300 1.4 TBP HDAC1 ATF1 TBL1XR1 NFRKB PTRF FEZF1 RAD21 ELK1 GATA2 CPED1 HMGN1P18
GH07F121075 1 ENCODE 12.9 +88.0 88036 1.8 PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 FOS GTF2B JUNB REST CPED1 ING3 GC07M121084 RNA5SP241 HMGN1P18
GH07F121022 1.1 Ensembl ENCODE 11.1 +35.1 35149 2.4 PKNOX1 FEZF1 ZNF664 CTBP1 ZNF366 PRDM10 ZSCAN29 NR2F6 HLF NR4A1 CPED1 TSPAN12 HMGN1P18
GH07F121032 1.1 Ensembl ENCODE 10.8 +44.2 44195 1.1 INSM2 ZNF175 FEZF1 BCL11B ZNF366 PRDM10 ZNF600 KLF8 ZBTB20 ZNF362 CPED1 HMGN1P18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPED1 Gene

120,988,677 bp from pter
121,297,444 bp from pter
308,768 bases
Plus strand

Genomic View for CPED1 Gene

Genes around CPED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPED1 Gene

Proteins for CPED1 Gene

  • Protein details for CPED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cadherin-like and PC-esterase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K1R3
    • Q6UXT1
    • Q86T76
    • Q86T84
    • Q8N2T5
    • Q96NC9

    Protein attributes for CPED1 Gene

    1026 amino acids
    Molecular mass:
    117491 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30538.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CPED1 Gene


neXtProt entry for CPED1 Gene

Post-translational modifications for CPED1 Gene

  • Glycosylation at Asn 251, Asn 404, Asn 413, Asn 737, Asn 791, and Asn 985
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CPED1 Gene

Domains & Families for CPED1 Gene

Protein Domains for CPED1 Gene


Suggested Antigen Peptide Sequences for CPED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PC-esterase family.
  • Belongs to the PC-esterase family.
genes like me logo Genes that share domains with CPED1: view

No data available for Gene Families for CPED1 Gene

Function for CPED1 Gene

genes like me logo Genes that share phenotypes with CPED1: view

Animal Model Products

miRNA for CPED1 Gene

miRTarBase miRNAs that target CPED1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPED1 Gene

Localization for CPED1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPED1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with CPED1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPED1 Gene

Pathways & Interactions for CPED1 Gene

SuperPathways for CPED1 Gene

No Data Available

Interacting Proteins for CPED1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000309772 A4D0V7-CPED1_HUMAN for CPED1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CPED1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPED1 Gene

Transcripts for CPED1 Gene

Unigene Clusters for CPED1 Gene

Cadherin-like and PC-esterase domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPED1 Gene

No ASD Table

Relevant External Links for CPED1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPED1 Gene

This gene is overexpressed in Artery - Tibial (x7.9), Artery - Coronary (x4.5), and Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for CPED1 Gene

This gene is overexpressed in Monocytes (48.5) and Ovary (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPED1 Gene

Protein tissue co-expression partners for CPED1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPED1 Gene:


SOURCE GeneReport for Unigene cluster for CPED1 Gene:

genes like me logo Genes that share expression patterns with CPED1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPED1 Gene

Orthologs for CPED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPED1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPED1 34 35
  • 99.25 (n)
(Bos Taurus)
Mammalia CPED1 34 35
  • 86.88 (n)
(Canis familiaris)
Mammalia CPED1 34 35
  • 84.78 (n)
(Rattus norvegicus)
Mammalia Cped1 34
  • 80.67 (n)
(Mus musculus)
Mammalia Cped1 34 16 35
  • 80.64 (n)
(Monodelphis domestica)
Mammalia CPED1 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CPED1 35
  • 63 (a)
(Gallus gallus)
Aves CPED1 34 35
  • 66.6 (n)
(Anolis carolinensis)
Reptilia CPED1 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cped1 34
  • 59.7 (n)
(Danio rerio)
Actinopterygii cped1 34 35
  • 51.59 (n)
Species where no ortholog for CPED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPED1 Gene

Gene Tree for CPED1 (if available)
Gene Tree for CPED1 (if available)

Paralogs for CPED1 Gene

(2) SIMAP similar genes for CPED1 Gene using alignment to 6 proteins: Pseudogenes for CPED1 Gene

genes like me logo Genes that share paralogs with CPED1: view

No data available for Paralogs for CPED1 Gene

Variants for CPED1 Gene

Sequence variations from dbSNP and Humsavar for CPED1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1005400 -- 121,098,215(+) TTAGC(A/G)TCTAA intron-variant
rs10085474 -- 121,193,985(+) AACAT(A/G)GATGA intron-variant
rs10085563 -- 121,055,438(+) ATATC(A/G)TTTAT intron-variant
rs10085590 -- 121,191,969(+) TATAA(A/G)TAGGC intron-variant
rs10155891 -- 121,060,826(+) ttttg(C/T)gcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPED1 Gene

Variant ID Type Subtype PubMed ID
nsv981572 CNV duplication 23825009
nsv831114 CNV loss 17160897
nsv7405 OTHER inversion 18451855
nsv608327 CNV loss 21841781
nsv5930 CNV insertion 18451855
nsv528485 CNV loss 19592680
nsv523626 CNV loss 19592680
nsv474817 CNV novel sequence insertion 20440878
nsv471958 CNV novel sequence insertion 20440878
nsv1133108 OTHER inversion 24896259
nsv1115001 CNV deletion 24896259
nsv1115000 CNV deletion 24896259
nsv1075992 CNV deletion 25765185
nsv1034353 CNV loss 25217958
nsv1030988 CNV gain 25217958
nsv1021918 CNV loss 25217958
esv3614817 CNV loss 21293372
esv3614814 CNV loss 21293372
esv3572116 CNV loss 25503493
esv3542353 CNV deletion 23714750
esv3276606 CNV deletion 24192839
esv2759558 CNV loss 17122850
esv2735080 CNV deletion 23290073
esv2735079 CNV deletion 23290073
esv2669346 CNV deletion 23128226
esv2523024 CNV deletion 19546169
esv24150 CNV loss 19812545
esv1968318 CNV deletion 18987734
esv1560116 CNV deletion 17803354
dgv3655n106 CNV deletion 24896259

Variation tolerance for CPED1 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.78; 73.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPED1 Gene

Disorders for CPED1 Gene

Relevant External Links for CPED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPED1 Gene

Publications for CPED1 Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V. … Aravind L. (Biol. Direct 2010) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. (PMID: 24945404) Kemp J.P. … Evans D.M. (PLoS Genet. 2014) 3 64
  5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3 64

Products for CPED1 Gene

Sources for CPED1 Gene

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