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Aliases for CPEB4 Gene

Aliases for CPEB4 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 4 2 3 5
  • CPE-Binding Protein 4 3 4
  • CPE-BP4 3 4
  • HCPEB-4 3 4
  • KIAA1673 4

External Ids for CPEB4 Gene

Previous GeneCards Identifiers for CPEB4 Gene

  • GC05P173250
  • GC05P173297
  • GC05P173248
  • GC05P168411
  • GC05P173315

Summaries for CPEB4 Gene

GeneCards Summary for CPEB4 Gene

CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation and Oocyte meiosis. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB4 Gene

Genomics for CPEB4 Gene

Regulatory Elements for CPEB4 Gene

Enhancers for CPEB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPEB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB4 Gene

173,888,280 bp from pter
173,961,976 bp from pter
73,697 bases
Plus strand

Genomic View for CPEB4 Gene

Genes around CPEB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB4 Gene

Proteins for CPEB4 Gene

  • Protein details for CPEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B7ZLQ7
    • Q7Z310
    • Q8N405
    • Q9C0J0

    Protein attributes for CPEB4 Gene

    729 amino acids
    Molecular mass:
    80152 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPEB4 Gene

    Alternative splice isoforms for CPEB4 Gene


neXtProt entry for CPEB4 Gene

Proteomics data for CPEB4 Gene at MOPED

Post-translational modifications for CPEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB4 Gene

Domains & Families for CPEB4 Gene

Gene Families for CPEB4 Gene

Protein Domains for CPEB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB4: view

Function for CPEB4 Gene

Gene Ontology (GO) - Molecular Function for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0043022 ribosome binding IBA --
genes like me logo Genes that share ontologies with CPEB4: view
genes like me logo Genes that share phenotypes with CPEB4: view

Animal Models for CPEB4 Gene

MGI Knock Outs for CPEB4:

Animal Model Products

miRNA for CPEB4 Gene

miRTarBase miRNAs that target CPEB4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB4 Gene

Localization for CPEB4 Gene

Subcellular locations from

Jensen Localization Image for CPEB4 Gene COMPARTMENTS Subcellular localization image for CPEB4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPEB4 Gene

Pathways & Interactions for CPEB4 Gene

genes like me logo Genes that share pathways with CPEB4: view

Pathways by source for CPEB4 Gene

Gene Ontology (GO) - Biological Process for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0043524 negative regulation of neuron apoptotic process ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for SIGNOR curated interactions for CPEB4 Gene

Drugs & Compounds for CPEB4 Gene

No Compound Related Data Available

Transcripts for CPEB4 Gene

Unigene Clusters for CPEB4 Gene

Cytoplasmic polyadenylation element binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for CPEB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPEB4 Gene

mRNA expression in normal human tissues for CPEB4 Gene

mRNA differential expression in normal tissues according to GTEx for CPEB4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CPEB4 Gene

This gene is overexpressed in Placenta (24.0), Adrenal (17.5), Peripheral blood mononuclear cells (10.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPEB4 Gene

SOURCE GeneReport for Unigene cluster for CPEB4 Gene Hs.127126

genes like me logo Genes that share expression patterns with CPEB4: view

Protein tissue co-expression partners for CPEB4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CPEB4 Gene

Orthologs for CPEB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPEB4 35
  • 95.52 (n)
  • 99.59 (a)
CPEB4 36
  • 99 (a)
(Mus musculus)
Mammalia Cpeb4 35
  • 93 (n)
  • 98.35 (a)
Cpeb4 16
Cpeb4 36
  • 98 (a)
(Pan troglodytes)
Mammalia CPEB4 35
  • 99.73 (n)
  • 100 (a)
CPEB4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cpeb4 35
  • 92.46 (n)
  • 98.89 (a)
(Canis familiaris)
Mammalia CPEB4 36
  • 99 (a)
(Monodelphis domestica)
Mammalia CPEB4 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia CPEB4 36
  • 97 (a)
(Gallus gallus)
Aves CPEB4 35
  • 86.4 (n)
  • 95.36 (a)
CPEB4 36
  • 97 (a)
(Anolis carolinensis)
Reptilia CPEB4 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb4 35
  • 83.73 (n)
  • 94.37 (a)
Str.4214 35
(Danio rerio)
Actinopterygii cpeb4 35
  • 72.06 (n)
  • 78.53 (a)
zgc66166 35
cpeb4 36
  • 77 (a)
CPEB4 (2 of 3) 36
  • 99 (a)
CPEB4 (3 of 3) 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11294 35
fruit fly
(Drosophila melanogaster)
Insecta orb2 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea cpb-1 36
  • 32 (a)
cpb-2 36
  • 29 (a)
fog-1 36
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14697 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 80 (a)
-- 36
  • 90 (a)
Species with no ortholog for CPEB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB4 Gene

Gene Tree for CPEB4 (if available)
Gene Tree for CPEB4 (if available)

Paralogs for CPEB4 Gene

Paralogs for CPEB4 Gene

(5) SIMAP similar genes for CPEB4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB4: view

Variants for CPEB4 Gene

Sequence variations from dbSNP and Humsavar for CPEB4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs747472 -- 173,926,511(-) TCTAC(A/G)CTACC intron-variant
rs2659179 -- 173,895,531(+) TGCTG(C/G)AGTGC intron-variant
rs966544 -- 173,923,402(+) TCTCA(A/G)TCATT intron-variant
rs969518 -- 173,953,343(+) TAGAA(C/T)GGGAG intron-variant
rs969519 -- 173,953,592(+) TTTGT(A/T)CTGTG intron-variant

Variation tolerance for CPEB4 Gene

Residual Variation Intolerance Score: 8.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CPEB4 Gene

Disorders for CPEB4 Gene

Relevant External Links for CPEB4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPEB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB4 Gene

Publications for CPEB4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3
  3. The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4. (PMID: 26209100) Huang W. … Luo R. (Diagn Pathol 2015) 3
  4. MicroRNA-203-mediated posttranscriptional deregulation of CPEB4 contributes to colorectal cancer progression. (PMID: 26361147) Zhong X. … Liu X. (Biochem. Biophys. Res. Commun. 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for CPEB4 Gene

Sources for CPEB4 Gene