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Aliases for CPEB4 Gene

Aliases for CPEB4 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 4 2 3 5
  • CPE-Binding Protein 4 3 4
  • CPE-BP4 3 4
  • HCPEB-4 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 4 3
  • KIAA1673 4

External Ids for CPEB4 Gene

Previous GeneCards Identifiers for CPEB4 Gene

  • GC05P173250
  • GC05P173297
  • GC05P173248
  • GC05P168411
  • GC05P173315

Summaries for CPEB4 Gene

GeneCards Summary for CPEB4 Gene

CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Dorso-ventral axis formation. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB3.

UniProtKB/Swiss-Prot for CPEB4 Gene

  • RNA-binding protein which, in contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB4 Gene

Genomics for CPEB4 Gene

Regulatory Elements for CPEB4 Gene

Enhancers for CPEB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F173774 1.7 FANTOM5 Ensembl ENCODE 20.3 -109.0 -108956 10.2 HDGF PKNOX1 ARNT YY1 FOS KLF13 ZNF263 REST SMARCB1 ZNF592 CPEB4 BOD1 LINC01485 LINC01484
GH05F173865 1.6 FANTOM5 Ensembl ENCODE 19 -20.4 -20411 4.3 ATF1 PKNOX1 CREB3L1 ARID4B FEZF1 DMAP1 ZNF2 ZNF48 ZNF121 GATA2 CPEB4 BOD1 HMP19 PIR46909
GH05F173857 1.6 FANTOM5 Ensembl ENCODE 12.5 -28.8 -28826 4.3 HDGF PKNOX1 ATF1 ZNF133 FEZF1 YBX1 ZNF121 GATA2 ZNF207 ZNF416 LOC102724551 RPL12P22 ENSG00000254011 ENSG00000249722 ENSG00000251670 ENSG00000253172 CPEB4 BOD1 CREBRF PIR46909
GH05F173819 1.6 FANTOM5 Ensembl ENCODE 12.4 -64.6 -64563 7.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 CPEB4 BOD1 LINC01485 PIR46909
GH05F173864 1.1 Ensembl ENCODE 12.5 -23.4 -23414 1.5 ELF3 PKNOX1 ZNF792 SAP130 ETV1 DMAP1 ZNF384 ZNF644 ZKSCAN1 ZNF335 CPEB4 BOD1 PIR46909 LINC01485
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPEB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB4 Gene

173,888,280 bp from pter
173,961,976 bp from pter
73,697 bases
Plus strand

Genomic View for CPEB4 Gene

Genes around CPEB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB4 Gene

Proteins for CPEB4 Gene

  • Protein details for CPEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B7ZLQ7
    • Q7Z310
    • Q8N405
    • Q9C0J0

    Protein attributes for CPEB4 Gene

    729 amino acids
    Molecular mass:
    80152 Da
    Quaternary structure:
    • Interacts with TOB1.

    Three dimensional structures from OCA and Proteopedia for CPEB4 Gene

    Alternative splice isoforms for CPEB4 Gene


neXtProt entry for CPEB4 Gene

Post-translational modifications for CPEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB4 Gene

Domains & Families for CPEB4 Gene

Gene Families for CPEB4 Gene

Protein Domains for CPEB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB4: view

Function for CPEB4 Gene

Molecular function for CPEB4 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which, in contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR.

Gene Ontology (GO) - Molecular Function for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding IBA --
genes like me logo Genes that share ontologies with CPEB4: view
genes like me logo Genes that share phenotypes with CPEB4: view

Animal Models for CPEB4 Gene

MGI Knock Outs for CPEB4:

Animal Model Products

miRNA for CPEB4 Gene

miRTarBase miRNAs that target CPEB4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB4 Gene

Localization for CPEB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB4 Gene

Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CPEB4: view

Pathways & Interactions for CPEB4 Gene

genes like me logo Genes that share pathways with CPEB4: view

Pathways by source for CPEB4 Gene

Gene Ontology (GO) - Biological Process for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0006412 translation IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
GO:0036294 cellular response to decreased oxygen levels ISS --
GO:0042149 cellular response to glucose starvation ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for SIGNOR curated interactions for CPEB4 Gene

Transcripts for CPEB4 Gene

Unigene Clusters for CPEB4 Gene

Cytoplasmic polyadenylation element binding protein 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for CPEB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPEB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPEB4 Gene

mRNA differential expression in normal tissues according to GTEx for CPEB4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CPEB4 Gene

This gene is overexpressed in Placenta (24.0), Adrenal (17.5), Peripheral blood mononuclear cells (10.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPEB4 Gene

Protein tissue co-expression partners for CPEB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPEB4 Gene:


SOURCE GeneReport for Unigene cluster for CPEB4 Gene:

genes like me logo Genes that share expression patterns with CPEB4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CPEB4 Gene

Orthologs for CPEB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPEB4 34 35
  • 99.73 (n)
(Canis familiaris)
Mammalia CPEB4 35
  • 99 (a)
(Monodelphis domestica)
Mammalia CPEB4 35
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia CPEB4 35
  • 97 (a)
(Bos Taurus)
Mammalia CPEB4 34 35
  • 95.52 (n)
(Mus musculus)
Mammalia Cpeb4 34 16 35
  • 93 (n)
(Rattus norvegicus)
Mammalia Cpeb4 34
  • 92.46 (n)
(Gallus gallus)
Aves CPEB4 34 35
  • 86.4 (n)
(Anolis carolinensis)
Reptilia CPEB4 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb4 34
  • 83.73 (n)
Str.4214 34
(Danio rerio)
Actinopterygii CPEB4 (2 of 3) 35
  • 99 (a)
CPEB4 (3 of 3) 35
  • 77 (a)
cpeb4 34 35
  • 72.06 (n)
zgc66166 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11294 34
fruit fly
(Drosophila melanogaster)
Insecta orb2 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea cpb-1 35
  • 32 (a)
cpb-2 35
  • 29 (a)
fog-1 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 90 (a)
-- 35
  • 80 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14697 34
Species where no ortholog for CPEB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB4 Gene

Gene Tree for CPEB4 (if available)
Gene Tree for CPEB4 (if available)

Paralogs for CPEB4 Gene

Paralogs for CPEB4 Gene

(5) SIMAP similar genes for CPEB4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB4: view

Variants for CPEB4 Gene

Sequence variations from dbSNP and Humsavar for CPEB4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10043713 -- 173,926,946(+) gagtt(C/T)gagat intron-variant
rs10054905 -- 173,903,413(+) AAGGA(G/T)CTAAT intron-variant
rs10059384 -- 173,922,113(+) GTTCA(A/G)TGGCC intron-variant
rs10065165 -- 173,943,786(+) AAATA(C/T)ACTGT intron-variant
rs10074386 -- 173,952,103(+) CCTTG(A/G)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB4 Gene

Variant ID Type Subtype PubMed ID
nsv600298 CNV gain 21841781
nsv600323 CNV gain 21841781
nsv950446 CNV duplication 24416366

Variation tolerance for CPEB4 Gene

Residual Variation Intolerance Score: 8.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB4 Gene

Disorders for CPEB4 Gene

Relevant External Links for CPEB4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPEB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB4 Gene

Publications for CPEB4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PMID: 22210626) Mead S. … Collinge J. (Hum. Mol. Genet. 2012) 3 46 64
  3. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N. … Hoshino S. (EMBO J. 2011) 3 4 64
  4. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K. … Weersma R.K. (Hum. Mol. Genet. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for CPEB4 Gene

Sources for CPEB4 Gene

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