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Aliases for CPEB4 Gene

Aliases for CPEB4 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 4 2 3
  • CPE-Binding Protein 4 3 4
  • KIAA1673 4 6
  • CPE-BP4 3 4
  • HCPEB-4 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 4 3

External Ids for CPEB4 Gene

Summaries for CPEB4 Gene

GeneCards Summary for CPEB4 Gene

CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPEB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB4 Gene

Genomics for CPEB4 Gene

Genomic Location for CPEB4 Gene

Start:
173,888,280 bp from pter
End:
173,961,976 bp from pter
Size:
73,697 bases
Orientation:
Plus strand

Genomic View for CPEB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB4 Gene

Regulatory Elements for CPEB4 Gene

Proteins for CPEB4 Gene

  • Protein details for CPEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RY0-CPEB4_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Protein Accession:
    Q17RY0
    Secondary Accessions:
    • B7ZLQ7
    • Q7Z310
    • Q8N405
    • Q9C0J0

    Protein attributes for CPEB4 Gene

    Size:
    729 amino acids
    Molecular mass:
    80152 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPEB4 Gene

    Alternative splice isoforms for CPEB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB4 Gene

Proteomics data for CPEB4 Gene at MOPED

Post-translational modifications for CPEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPEB4 Gene

No data available for DME Specific Peptides for CPEB4 Gene

Domains for CPEB4 Gene

Gene Families for CPEB4 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CPEB4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CPEB4_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q17RY0
Family:
  • Belongs to the RRM CPEB family.:
    • Q17RY0
genes like me logo Genes that share domains with CPEB4: view

Function for CPEB4 Gene

Gene Ontology (GO) - Molecular Function for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 21336257
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CPEB4: view
genes like me logo Genes that share phenotypes with CPEB4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPEB4 Gene

Localization for CPEB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB4 Gene COMPARTMENTS Subcellular localization image for CPEB4 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0014069 postsynaptic density ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with CPEB4: view

Pathways for CPEB4 Gene

SuperPathways for CPEB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
GO:0036294 cellular response to decreased oxygen levels ISS --
GO:0042149 cellular response to glucose starvation ISS --
GO:0043524 negative regulation of neuron apoptotic process ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for Pathways by source for CPEB4 Gene

Transcripts for CPEB4 Gene

Unigene Clusters for CPEB4 Gene

Cytoplasmic polyadenylation element binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for CPEB4 Gene

GeneLoc Exon Structure for
CPEB4
ECgene alternative splicing isoforms for
CPEB4

Expression for CPEB4 Gene

mRNA expression in normal human tissues for CPEB4 Gene

mRNA differential expression in normal tissues according to GTEx for CPEB4 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPEB4 Gene

SOURCE GeneReport for Unigene cluster for CPEB4 Gene Hs.127126

genes like me logo Genes that share expressions with CPEB4: view

Orthologs for CPEB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB4 36
  • 99.73 (n)
  • 100 (a)
CPEB4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB4 36
  • 95.52 (n)
  • 99.59 (a)
CPEB4 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPEB4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpeb4 36
  • 93 (n)
  • 98.35 (a)
Cpeb4 16
Cpeb4 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPEB4 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB4 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpeb4 36
  • 92.46 (n)
  • 98.89 (a)
chicken
(Gallus gallus)
Aves CPEB4 36
  • 86.4 (n)
  • 95.36 (a)
CPEB4 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPEB4 37
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb4 36
  • 83.73 (n)
  • 94.37 (a)
Str.4214 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11294 36
zebrafish
(Danio rerio)
Actinopterygii cpeb4 36
  • 72.06 (n)
  • 78.53 (a)
cpeb4 37
  • 77 (a)
OneToMany
CPEB4 (2 of 3) 37
  • 99 (a)
OneToMany
CPEB4 (3 of 3) 37
  • 77 (a)
OneToMany
zgc66166 36
fruit fly
(Drosophila melanogaster)
Insecta orb2 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 37
  • 32 (a)
ManyToMany
cpb-2 37
  • 29 (a)
ManyToMany
fog-1 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14697 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 80 (a)
ManyToMany
-- 37
  • 90 (a)
ManyToMany
Species with no ortholog for CPEB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB4 Gene

ENSEMBL:
Gene Tree for CPEB4 (if available)
TreeFam:
Gene Tree for CPEB4 (if available)

Paralogs for CPEB4 Gene

Paralogs for CPEB4 Gene

Selected SIMAP similar genes for CPEB4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB4: view

Variants for CPEB4 Gene

Sequence variations from dbSNP and Humsavar for CPEB4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs359413 -- 173,917,175(-) TTTAT(C/T)CCCAA intron-variant
rs359414 -- 173,917,101(-) GTTTC(C/T)AGAGC intron-variant
rs359415 -- 173,918,484(+) TGTCT(C/G/T)TGGGT intron-variant
rs359416 -- 173,919,082(+) AGTTC(C/T)CTTAT intron-variant
rs359417 -- 173,919,575(+) GCTAC(A/G)AAAAC intron-variant

Relevant External Links for CPEB4 Gene

HapMap Linkage Disequilibrium report
CPEB4

No data available for Structural Variations from Database of Genomic Variants (DGV) for CPEB4 Gene

Disorders for CPEB4 Gene

Relevant External Links for CPEB4

Genetic Association Database (GAD)
CPEB4
Human Genome Epidemiology (HuGE) Navigator
CPEB4
genes like me logo Genes that share disorders with CPEB4: view

No data available for UniProtKB/Swiss-Prot for CPEB4 Gene

Publications for CPEB4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PMID: 20935629) Heid I.M. … Lindgren C.M. (Nat. Genet. 2010) 3 49
  5. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PMID: 22210626) Mead S. … Collinge J. (Hum. Mol. Genet. 2012) 3 49

Products for CPEB4 Gene

Sources for CPEB4 Gene

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