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Aliases for CPEB4 Gene

Aliases for CPEB4 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 4 2 3 5
  • CPE-Binding Protein 4 3 4
  • CPE-BP4 3 4
  • HCPEB-4 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 4 3
  • KIAA1673 4

External Ids for CPEB4 Gene

Previous GeneCards Identifiers for CPEB4 Gene

  • GC05P173250
  • GC05P173297
  • GC05P173248
  • GC05P168411
  • GC05P173315

Summaries for CPEB4 Gene

GeneCards Summary for CPEB4 Gene

CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation and Oocyte meiosis. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB2.

UniProtKB/Swiss-Prot for CPEB4 Gene

  • Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB4 Gene

Genomics for CPEB4 Gene

Regulatory Elements for CPEB4 Gene

Enhancers for CPEB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G173777 2 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -107.5 -107525 7.4 HDGF FOXA2 PKNOX1 ARNT ZBTB7B YY1 ZNF766 FOS KLF13 REST CPEB4 BOD1 LINC01485 LINC01484
GH05G173865 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19 -20.4 -20411 4.3 PKNOX1 CREB3L1 SIN3A ARID4B DMAP1 FEZF1 ZNF2 ZBTB7B CBX5 ZNF143 CPEB4 BOD1 HMP19 PIR46909
GH05G173819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -64.6 -64563 7.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CPEB4 BOD1 LINC01485 PIR46909
GH05G173857 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -28.8 -28826 4.3 HDGF PKNOX1 ATF1 ZNF133 FEZF1 YBX1 TCF12 ZNF121 GATA2 ZNF207 CPEB4 BOD1 CREBRF PIR46909 LINC01485
GH05G173864 1.3 Ensembl ENCODE dbSUPER 12.5 -23.7 -23668 1.0 ELF3 PKNOX1 ZNF792 SAP130 ETV1 DMAP1 ZNF384 ZNF644 GATA3 CTBP1 CPEB4 BOD1 PIR46909 LINC01485
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPEB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB4 Gene

Chromosome:
5
Start:
173,888,280 bp from pter
End:
173,961,976 bp from pter
Size:
73,697 bases
Orientation:
Plus strand

Genomic View for CPEB4 Gene

Genes around CPEB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB4 Gene

Proteins for CPEB4 Gene

  • Protein details for CPEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RY0-CPEB4_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Protein Accession:
    Q17RY0
    Secondary Accessions:
    • B7ZLQ7
    • Q7Z310
    • Q8N405
    • Q9C0J0

    Protein attributes for CPEB4 Gene

    Size:
    729 amino acids
    Molecular mass:
    80152 Da
    Quaternary structure:
    • Interacts with TOB1.

    Three dimensional structures from OCA and Proteopedia for CPEB4 Gene

    Alternative splice isoforms for CPEB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB4 Gene

Post-translational modifications for CPEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB4 Gene

Domains & Families for CPEB4 Gene

Gene Families for CPEB4 Gene

Protein Domains for CPEB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q17RY0

UniProtKB/Swiss-Prot:

CPEB4_HUMAN :
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (PubMed:24990967). The interdomain linker (564-579) acts as a hinge to fix the relative orientation of the 2 RRMs (PubMed:24990967). The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs (By similarity). Unlike in CPEB1, a continuous polar interface is formed between the 2 RRMs (PubMed:24990967).
  • Belongs to the RRM CPEB family.
Domain:
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (PubMed:24990967). The interdomain linker (564-579) acts as a hinge to fix the relative orientation of the 2 RRMs (PubMed:24990967). The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs (By similarity). Unlike in CPEB1, a continuous polar interface is formed between the 2 RRMs (PubMed:24990967).
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB4: view

Function for CPEB4 Gene

Molecular function for CPEB4 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Gene Ontology (GO) - Molecular Function for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, nucleic acid binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005515 protein binding IPI 21336257
genes like me logo Genes that share ontologies with CPEB4: view
genes like me logo Genes that share phenotypes with CPEB4: view

Animal Models for CPEB4 Gene

MGI Knock Outs for CPEB4:

Animal Model Products

CRISPR Products

miRNA for CPEB4 Gene

miRTarBase miRNAs that target CPEB4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB4 Gene

Localization for CPEB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB4 Gene

Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density ISS --
genes like me logo Genes that share ontologies with CPEB4: view

Pathways & Interactions for CPEB4 Gene

genes like me logo Genes that share pathways with CPEB4: view

Pathways by source for CPEB4 Gene

Gene Ontology (GO) - Biological Process for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0006412 translation IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
GO:0036294 cellular response to decreased oxygen levels ISS --
GO:0042149 cellular response to glucose starvation ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for SIGNOR curated interactions for CPEB4 Gene

Drugs & Compounds for CPEB4 Gene

No Compound Related Data Available

Transcripts for CPEB4 Gene

Unigene Clusters for CPEB4 Gene

Cytoplasmic polyadenylation element binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for CPEB4 Gene

GeneLoc Exon Structure for
CPEB4
ECgene alternative splicing isoforms for
CPEB4

Expression for CPEB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPEB4 Gene

mRNA differential expression in normal tissues according to GTEx for CPEB4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CPEB4 Gene

This gene is overexpressed in Placenta (24.0), Adrenal (17.5), Peripheral blood mononuclear cells (10.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPEB4 Gene



Protein tissue co-expression partners for CPEB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPEB4 Gene:

CPEB4

SOURCE GeneReport for Unigene cluster for CPEB4 Gene:

Hs.127126

mRNA Expression by UniProt/SwissProt for CPEB4 Gene:

Q17RY0-CPEB4_HUMAN
Tissue specificity: Expressed in pancreas in islets and ductal cells (at protein level) (PubMed:22138752). Expressed in melanocytes (PubMed:27857118).

Evidence on tissue expression from TISSUES for CPEB4 Gene

  • Nervous system(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with CPEB4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPEB4 Gene

Orthologs for CPEB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB4 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia CPEB4 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPEB4 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB4 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB4 34 35
  • 95.52 (n)
mouse
(Mus musculus)
Mammalia Cpeb4 34 16 35
  • 93 (n)
rat
(Rattus norvegicus)
Mammalia Cpeb4 34
  • 92.46 (n)
chicken
(Gallus gallus)
Aves CPEB4 34 35
  • 86.4 (n)
lizard
(Anolis carolinensis)
Reptilia CPEB4 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb4 34
  • 83.73 (n)
Str.4214 34
zebrafish
(Danio rerio)
Actinopterygii CPEB4 (2 of 3) 35
  • 99 (a)
OneToMany
CPEB4 (3 of 3) 35
  • 77 (a)
OneToMany
cpeb4 34 35
  • 72.06 (n)
zgc66166 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11294 34
fruit fly
(Drosophila melanogaster)
Insecta orb2 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 35
  • 32 (a)
ManyToMany
cpb-2 35
  • 29 (a)
ManyToMany
fog-1 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 90 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14697 34
Species where no ortholog for CPEB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB4 Gene

ENSEMBL:
Gene Tree for CPEB4 (if available)
TreeFam:
Gene Tree for CPEB4 (if available)

Paralogs for CPEB4 Gene

Paralogs for CPEB4 Gene

(5) SIMAP similar genes for CPEB4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB4: view

Variants for CPEB4 Gene

Sequence variations from dbSNP and Humsavar for CPEB4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000031740 -- 173,961,479(+) TGGTG(C/T)GTCTG downstream-variant-500B
rs1000081230 -- 173,915,925(+) AAAAT(C/T)AGGGA intron-variant
rs1000095673 -- 173,911,942(+) AAAAC(A/G)TTTTA intron-variant
rs1000176169 -- 173,901,598(+) TTAAA(C/T)CACTT intron-variant
rs1000209149 -- 173,905,142(+) CCTTT(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB4 Gene

Variant ID Type Subtype PubMed ID
nsv600298 CNV gain 21841781
nsv600323 CNV gain 21841781
nsv950446 CNV duplication 24416366

Variation tolerance for CPEB4 Gene

Residual Variation Intolerance Score: 8.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB4 Gene

Human Gene Mutation Database (HGMD)
CPEB4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB4 Gene

Disorders for CPEB4 Gene

Relevant External Links for CPEB4

Genetic Association Database (GAD)
CPEB4
Human Genome Epidemiology (HuGE) Navigator
CPEB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB4

No disorders were found for CPEB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB4 Gene

Publications for CPEB4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle. (PMID: 26398195) GiangarrA V. … Mendez R. (PLoS ONE 2015) 3 4 64
  3. Key contribution of CPEB4-mediated translational control to cancer progression. (PMID: 22138752) Ortiz-Zapater E. … Navarro P. (Nat. Med. 2012) 3 4 64
  4. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PMID: 22210626) Mead S. … Collinge J. (Hum. Mol. Genet. 2012) 3 46 64
  5. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N. … Hoshino S. (EMBO J. 2011) 3 4 64

Products for CPEB4 Gene

Sources for CPEB4 Gene

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