CPEB3 Gene
protein-coding GIFtS: 50
GCID: GC10M093798
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cytoplasmic polyadenylation element binding protein 3
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Aliases
for CPEB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytoplasmic Polyadenylation Element Binding Protein 31 2 | | KIAA09401 3 5 | | CPE-BP32 3 | | CPE-Binding Protein 32 3 | | HCPEB-31 | | Cytoplasmic Polyadenylation Element-Binding Protein 32 |
Export aliases for CPEB3 gene to outside databasesPrevious GC identifers: GC10M093939 GC10M093472 GC10M093473 GC10M087437 |
Summaries
for CPEB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CPEB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CPEB3 gene promoter:
Pax-5 Nkx2-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 LCR-F1 HEN1 COMP1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CPEB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPEB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.32 Ensembl cytogenetic band: 10q23.32 HGNC cytogenetic band: 10q23.33CPEB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M093798: view genomic region
(about GC identifiers)
Start:
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93,808,397 bp from pter |
End:
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94,050,875 bp from pter |
Size:
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242,479 bases |
Orientation:
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minus strand |
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Proteins
for CPEB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CPEB3_HUMAN, Q8NE35 (See
protein sequence)Recommended Name: Cytoplasmic polyadenylation element-binding protein 3 Size: 698 amino acids; 76014 Da
Sequence caution: Sequence=BAA76784.2; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for CPEB3:2DNL (3D)
Secondary accessions: Q5T389 Q9NQJ7 Q9Y2E9Alternative splicing: 2 isoforms: Q8NE35-1 Q8NE35-2 Explore the universe of human proteins at neXtProt for CPEB3: NX_Q8NE35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NE35
CPEB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171608.1 NP_055727.3
ENSEMBL proteins: ENSP00000377760 ENSP00000265997 ENSP00000398310
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045202 | synapse |
IEA | -- |
CPEB3 for ontologies About GeneDecksing
CPEB3 Antibody Products:
Assay Products for CPEB3: |
Protein
Domains /
Families
for CPEB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPEB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NE35ProtoNet protein and cluster: Q8NE35 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: CPEB3_HUMAN, Q8NE35Similarity: Belongs to the RRM CPEB familySimilarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for CPEB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CPEB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPEB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPEB3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CPEB3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CPEB3:
|
Pathways & Interactions
for CPEB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPEB3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for CPEB3 (Q8NE352, 3 ENSP000002659974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0017148 | negative regulation of translation |
IEA | -- |
CPEB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CPEB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CPEB3
Search CenterWatch for drugs/clinical trials and news about CPEB3
|
Transcripts
for CPEB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CPEB3 gene (2 alternative transcripts): NM_001178137.1 NM_014912.4 Unigene Cluster for CPEB3: Cytoplasmic polyadenylation element binding protein 3 Hs.131683 [show with all ESTs]Unigene Representative Sequence: NM_0149123 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394210(uc001khu.2 uc001khw.2 uc010qnn.2) ENST00000265997
ENST00000412050(uc001khv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CPEB3 (NM_014912) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CPEB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPEB3 |
Additional cDNA sequence: AB023157.1 AK127060.1 AK302576.1 BC036444.2 7 DOTS entries: DT.452787 DT.402838 DT.100022631 DT.65285379 DT.92420332 DT.121222591 DT.75127040 24/57 AceView cDNA sequences (see all 57): BX109142 NM_014912 BU159553 BF509277 BE673893 AB023157 CK821783 AI016770 CK821782 AL600688 AK127060 CA429073 BQ001990 CA842835 BF223344 BU785488 BU948940 BX502175 BP343639 BX499410 AL703759 CA848776 BX486614 AI827590
GeneLoc Exon Structure
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Expression
for CPEB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPEB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTAAAATA
About this image
See CPEB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPEB3
SOURCE GeneReport for Unigene cluster: Hs.131683
SABiosciences Custom PCR Arrays for CPEB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPEB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPEB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPEB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPEB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPEB3 |
Orthologs
for CPEB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CPEB3 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for CPEB3 (if available)
TreeFam Gene Tree for CPEB3 (if available) |
Paralogs
for CPEB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CPEB3 gene
- CPEB22 CPEB42 ENSG000002608362 CPEB12
5 SIMAP similar genes for CPEB3 using alignment to 3 protein entries: CPEB3_HUMAN (see all proteins):DKFZp686L03182 CPEB 4 variant CPEB2 CPEB4 CPEB1
CPEB3 for paralogs About GeneDecksing
|
Genomic Variants
for CPEB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CPEB3 (93808397 - 94050875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CPEB3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPEB3 |
|
Disorders
/ Diseases
for CPEB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPEB3 for disorders About GeneDecksing
OMIM gene information: 610606
OMIM disorders: --
1  disease for CPEB3: About MalaCardsalzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: CPEB3 (3 documents)
Export disorders for CPEB3 gene to outside databases
|
Publications
for CPEB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPEB3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CPEB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- CPEB2, a novel putative translational regulator in mo use haploid germ cells. (PubMed id 12672660)1, 3 Kurihara Y....Uesugi S. (2003)
- Calpain 2 activated through N-methyl-D-aspartic acid r eceptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neu rons. (PubMed id 22711986)1 Wang C.F. and Huang Y.S. (2012)
- Anti-proliferative protein Tob negatively regulates C PEB3 target by recruiting Caf1 deadenylase. (PubMed id 21336257)1 Hosoda N....Hoshino S. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The human HDV-like CPEB3 ribozyme is intrinsically fa st-reacting. (PubMed id 20524672)1 Chadalavada D.M....Bevilacqua P.C. (2010)
- CPEB3 is associated with human episodic memory. (PubMed id 19503753)1 Vogler C....de Quervain D.J. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for CPEB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CPEB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPEB3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CPEB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CPEB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CPEB3 gene:
Search GeneIP for patents involving CPEB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CPEB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CPEB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPEB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPEB3 | | | OriGene Protein Over-expression Lysate for CPEB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CPEB3 | | OriGene 3'-UTR Clone for CPEB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPEB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPEB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPEB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPEB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPEB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPEB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPEB3 |
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 | | | CPEB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPEB3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CPEB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPEB3 |
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