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Aliases for CPEB3 Gene

Aliases for CPEB3 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 3 2 3
  • CPE-Binding Protein 3 3 4
  • KIAA0940 4 6
  • CPE-BP3 3 4
  • HCPEB-3 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 3 3

External Ids for CPEB3 Gene

Summaries for CPEB3 Gene

GeneCards Summary for CPEB3 Gene

CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPEB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB3 Gene

Genomics for CPEB3 Gene

Genomic Location for CPEB3 Gene

Start:
92,046,692 bp from pter
End:
92,291,118 bp from pter
Size:
244,427 bases
Orientation:
Minus strand

Genomic View for CPEB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB3 Gene

Regulatory Elements for CPEB3 Gene

Proteins for CPEB3 Gene

  • Protein details for CPEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE35-CPEB3_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 3
    Protein Accession:
    Q8NE35
    Secondary Accessions:
    • Q5T389
    • Q9NQJ7
    • Q9Y2E9

    Protein attributes for CPEB3 Gene

    Size:
    698 amino acids
    Molecular mass:
    76014 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76784.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPEB3 Gene

    Alternative splice isoforms for CPEB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB3 Gene

Proteomics data for CPEB3 Gene at MOPED

Post-translational modifications for CPEB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPEB3 Gene

No data available for DME Specific Peptides for CPEB3 Gene

Domains for CPEB3 Gene

Gene Families for CPEB3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CPEB3 Gene

UniProtKB/Swiss-Prot:

CPEB3_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q8NE35
Family:
  • Belongs to the RRM CPEB family.:
    • Q8NE35
genes like me logo Genes that share domains with CPEB3: view

Function for CPEB3 Gene

Gene Ontology (GO) - Molecular Function for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 22730302
GO:0003730 mRNA 3-UTR binding ISS --
genes like me logo Genes that share ontologies with CPEB3: view

Phenotypes for CPEB3 Gene

GenomeRNAi human phenotypes for CPEB3:
genes like me logo Genes that share phenotypes with CPEB3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPEB3 Gene

Localization for CPEB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB3 Gene COMPARTMENTS Subcellular localization image for CPEB3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639532
GO:0005737 cytoplasm ISS --
GO:0030014 CCR4-NOT complex IDA 21336257
GO:0030425 dendrite ISS --
GO:0043005 neuron projection ISS --
genes like me logo Genes that share ontologies with CPEB3: view

Pathways for CPEB3 Gene

SuperPathways for CPEB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20639532
GO:0006412 translation IEA --
GO:0007616 long-term memory ISS --
GO:0017148 negative regulation of translation IDA 21336257
GO:0045727 positive regulation of translation ISS --
genes like me logo Genes that share ontologies with CPEB3: view

No data available for Pathways by source for CPEB3 Gene

Transcripts for CPEB3 Gene

Unigene Clusters for CPEB3 Gene

Cytoplasmic polyadenylation element binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB3 Gene

No ASD Table

Relevant External Links for CPEB3 Gene

GeneLoc Exon Structure for
CPEB3
ECgene alternative splicing isoforms for
CPEB3

Expression for CPEB3 Gene

mRNA expression in normal human tissues for CPEB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPEB3 Gene

SOURCE GeneReport for Unigene cluster for CPEB3 Gene Hs.131683

genes like me logo Genes that share expressions with CPEB3: view

Orthologs for CPEB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB3 36
  • 98.91 (n)
  • 99.02 (a)
CPEB3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB3 36
  • 92.78 (n)
  • 95.12 (a)
CPEB3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPEB3 36
  • 93.53 (n)
  • 96.41 (a)
CPEB3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpeb3 36
  • 90.84 (n)
  • 96.12 (a)
Cpeb3 16
Cpeb3 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPEB3 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB3 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpeb3 36
  • 90.9 (n)
  • 96.4 (a)
chicken
(Gallus gallus)
Aves CPEB3 36
  • 83.16 (n)
  • 90.47 (a)
CPEB3 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPEB3 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb3 36
  • 78.27 (n)
  • 85.39 (a)
zebrafish
(Danio rerio)
Actinopterygii cpeb3 36
  • 74.03 (n)
  • 79.68 (a)
cpeb3 37
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta orb2 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 37
  • 33 (a)
ManyToMany
cpb-2 37
  • 29 (a)
ManyToMany
fog-1 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 78 (a)
ManyToMany
-- 37
  • 88 (a)
ManyToMany
Species with no ortholog for CPEB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB3 Gene

ENSEMBL:
Gene Tree for CPEB3 (if available)
TreeFam:
Gene Tree for CPEB3 (if available)

Paralogs for CPEB3 Gene

Paralogs for CPEB3 Gene

Selected SIMAP similar genes for CPEB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CPEB3: view

Variants for CPEB3 Gene

Sequence variations from dbSNP and Humsavar for CPEB3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs701844 -- 92,094,442(-) cgtat(C/T)tttag intron-variant
rs701845 -- 92,097,659(-) AAGTT(A/C)TTTTA intron-variant
rs701846 -- 92,111,309(-) TTGAA(C/T)TTCTT intron-variant
rs701847 -- 92,113,481(-) TTTAA(C/G/T)TTGGT intron-variant
rs724425 -- 92,287,491(+) TCACC(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB3 Gene

Variant ID Type Subtype PubMed ID
nsv895893 CNV Gain 21882294
esv2671036 CNV Deletion 23128226
esv2664459 CNV Deletion 23128226
esv2739562 CNV Deletion 23290073

Relevant External Links for CPEB3 Gene

HapMap Linkage Disequilibrium report
CPEB3

Disorders for CPEB3 Gene

Relevant External Links for CPEB3

Genetic Association Database (GAD)
CPEB3
Human Genome Epidemiology (HuGE) Navigator
CPEB3
genes like me logo Genes that share disorders with CPEB3: view

No data available for UniProtKB/Swiss-Prot for CPEB3 Gene

Publications for CPEB3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  3. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPEB3 Gene

Sources for CPEB3 Gene

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