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Aliases for CPEB3 Gene

Aliases for CPEB3 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 3 2 3 5
  • CPE-Binding Protein 3 3 4
  • CPE-BP3 3 4
  • HCPEB-3 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 3 3
  • KIAA0940 4

External Ids for CPEB3 Gene

Previous GeneCards Identifiers for CPEB3 Gene

  • GC10M093939
  • GC10M093472
  • GC10M093473
  • GC10M093798
  • GC10M087437

Summaries for CPEB3 Gene

GeneCards Summary for CPEB3 Gene

CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Dorso-ventral axis formation. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB2.

UniProtKB/Swiss-Prot for CPEB3 Gene

  • Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB3 Gene

Genomics for CPEB3 Gene

Regulatory Elements for CPEB3 Gene

Enhancers for CPEB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F092238 1.6 FANTOM5 Ensembl ENCODE 29 +51.2 51213 4.2 ATF1 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CPEB3 KIF11 MARCH5 BTAF1 NHP2P1 ENSG00000199881
GH10F092210 1.4 FANTOM5 Ensembl ENCODE 14.3 +80.0 79954 2.1 HDGF TBL1XR1 BMI1 ZNF121 CBX5 FOS CREM ZNF362 CBFB JUNB CPEB3 TNKS2-AS1 EXOC6 BTAF1 TNKS2 GC10M092205 ENSG00000221042 NHP2P1
GH10F092100 1.2 Ensembl ENCODE 15.5 +189.3 189281 1.9 HDGF PKNOX1 SIN3A FEZF1 CBX5 FOS YY2 JUNB REST TBX21 CPEB3 MARCH5 ENSG00000252993 SDHCP2
GH10F092114 0.9 ENCODE 19.1 +176.7 176710 0.2 ELF3 MLX RARA YY1 CREM MIXL1 THAP11 PPARG KAT8 MIER3 CPEB3 ENSG00000252993 MARCH5 NHP2P1 SDHCP2
GH10F092289 1.1 ENCODE 15.2 -0.5 -522 3.3 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 CPEB3 RPL17P34 BTAF1 NHP2P1 MARCH5 GC10P092304
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPEB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB3 Gene

Chromosome:
10
Start:
92,046,692 bp from pter
End:
92,291,118 bp from pter
Size:
244,427 bases
Orientation:
Minus strand

Genomic View for CPEB3 Gene

Genes around CPEB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB3 Gene

Proteins for CPEB3 Gene

  • Protein details for CPEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE35-CPEB3_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 3
    Protein Accession:
    Q8NE35
    Secondary Accessions:
    • Q5T389
    • Q9NQJ7
    • Q9Y2E9

    Protein attributes for CPEB3 Gene

    Size:
    698 amino acids
    Molecular mass:
    76014 Da
    Quaternary structure:
    • Following synaptic activity, forms amyloid-like oligomers (By similarity). Aggregation requires an intact actin cytoskeleton (By similarity). Interacts with STAT5B; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532). Interacts with E3 ubiquitin-protein ligase NEURL1; this leads to monoubiquitination and activation of CPEB3 (By similarity). Interacts with CAPN2; this leads to cleavage of CPEB3 (By similarity). Interacts (via C-terminal RNA-binding region) with TOB1; TOB1 also binds CNOT7/CAF1 and recruits it to CPEB3 to form a ternary complex (PubMed:21336257). Interacts with SUMO-conjugating enzyme UBC9 (By similarity). Interacts with IPO5; the interaction is enhanced in a RAN-regulated manner following neuronal stimulation and mediates CPEB3 nuclear import (PubMed:22730302). Interacts with exportin XPO1/CRM1 (PubMed:22730302).
    Miscellaneous:
    • The CPEB3 gene contains an intron-encoded self-cleaving ribozyme which is structurally and biochemically related to human hepatitis delta virus ribozymes and which may play a role in the regulation of CPEB3 translation (PubMed:16990549). A polymorphism in the ribozyme sequence which influences cleavage activity of the ribozyme may play a role in episodic memory with carriers of a rare C allele-containing ribozyme showing significantly poorer memory recall performance than T allele carriers (PubMed:19503753).
    SequenceCaution:
    • Sequence=BAA76784.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPEB3 Gene

    Alternative splice isoforms for CPEB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB3 Gene

Post-translational modifications for CPEB3 Gene

  • Activated by NEURL1-mediated monoubiquitination, resulting in the growth of new dendritic spines and increased levels of GRIA1 and GRIA2. NEURL1-mediated monoubiquitination facilitates synaptic plasticity and hippocampal-dependent memory storage.
  • Following neuronal stimulation, cleaved by CAPN2 which abolishes its translational repressor activity, leading to translation of CPEB3 target mRNAs.
  • Phosphorylation is enhanced by neuronal stimulation.
  • Under basal unstimulated conditions when CPEB3 is mainly unaggregated, sumoylated and acts as a translational repressor. Following neuronal stimulation, becomes desumoylated and aggregated which is required for the translation of mRNA targets and for dendritic filopodia formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB3 Gene

Domains & Families for CPEB3 Gene

Gene Families for CPEB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NE35

UniProtKB/Swiss-Prot:

CPEB3_HUMAN :
  • The N-terminal Gln-rich region is required for the formation of amyloid-like oligomers and for the stability of long-term potentiation and spatial memory.
  • Belongs to the RRM CPEB family.
Domain:
  • The N-terminal Gln-rich region is required for the formation of amyloid-like oligomers and for the stability of long-term potentiation and spatial memory.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB3: view

Function for CPEB3 Gene

Molecular function for CPEB3 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195).

Gene Ontology (GO) - Molecular Function for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS,IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22730302
GO:0003730 mRNA 3-UTR binding ISS --
genes like me logo Genes that share ontologies with CPEB3: view
genes like me logo Genes that share phenotypes with CPEB3: view

Animal Models for CPEB3 Gene

MGI Knock Outs for CPEB3:

Animal Model Products

miRNA for CPEB3 Gene

miRTarBase miRNAs that target CPEB3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB3 Gene

Localization for CPEB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB3 Gene

Cytoplasm. Nucleus. Cell junction, synapse. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation (PubMed:20639532, PubMed:22730302). Nuclear import is mediated by importin IPO5 (By similarity). {ECO:0000250 UniProtKB:Q7TN99, ECO:0000269 PubMed:20639532, ECO:0000269 PubMed:22730302}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB3 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639532
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density IEA --
GO:0030014 CCR4-NOT complex IDA 21336257
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CPEB3: view

Pathways & Interactions for CPEB3 Gene

genes like me logo Genes that share pathways with CPEB3: view

Pathways by source for CPEB3 Gene

Gene Ontology (GO) - Biological Process for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20639532
GO:0006412 translation IEA --
GO:0007616 long-term memory ISS --
GO:0017148 negative regulation of translation IDA 21336257
GO:0045727 positive regulation of translation ISS --
genes like me logo Genes that share ontologies with CPEB3: view

No data available for SIGNOR curated interactions for CPEB3 Gene

Transcripts for CPEB3 Gene

Unigene Clusters for CPEB3 Gene

Cytoplasmic polyadenylation element binding protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB3 Gene

No ASD Table

Relevant External Links for CPEB3 Gene

GeneLoc Exon Structure for
CPEB3
ECgene alternative splicing isoforms for
CPEB3

Expression for CPEB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPEB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPEB3 Gene

This gene is overexpressed in Frontal cortex (32.3), Pancreas (20.2), Spinal cord (10.1), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPEB3 Gene



Protein tissue co-expression partners for CPEB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPEB3 Gene:

CPEB3

SOURCE GeneReport for Unigene cluster for CPEB3 Gene:

Hs.131683
genes like me logo Genes that share expression patterns with CPEB3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPEB3 Gene

Orthologs for CPEB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB3 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia CPEB3 34 35
  • 93.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB3 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB3 34 35
  • 92.78 (n)
rat
(Rattus norvegicus)
Mammalia Cpeb3 34
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Cpeb3 34 16 35
  • 90.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CPEB3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPEB3 34 35
  • 83.16 (n)
lizard
(Anolis carolinensis)
Reptilia CPEB3 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb3 34
  • 78.27 (n)
zebrafish
(Danio rerio)
Actinopterygii cpeb3 34 35
  • 74.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta orb2 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 35
  • 33 (a)
ManyToMany
cpb-2 35
  • 29 (a)
ManyToMany
fog-1 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 88 (a)
ManyToMany
-- 35
  • 78 (a)
ManyToMany
Species where no ortholog for CPEB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB3 Gene

ENSEMBL:
Gene Tree for CPEB3 (if available)
TreeFam:
Gene Tree for CPEB3 (if available)

Paralogs for CPEB3 Gene

Paralogs for CPEB3 Gene

(5) SIMAP similar genes for CPEB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CPEB3: view

Variants for CPEB3 Gene

Sequence variations from dbSNP and Humsavar for CPEB3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1022985 -- 92,121,948(-) AGCCA(A/G)AGTCA intron-variant
rs10509642 -- 92,086,957(+) TTATC(C/T)GGGAC intron-variant
rs10509643 -- 92,155,896(+) TAGGC(A/G)ACTTT intron-variant
rs10534634 -- 92,203,338(+) AGATG(-/AT)ATATA intron-variant
rs10587336 -- 92,236,987(+) ATAAA(-/CT)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB3 Gene

Variant ID Type Subtype PubMed ID
esv2664459 CNV deletion 23128226
esv2671036 CNV deletion 23128226
esv2739562 CNV deletion 23290073
esv2761614 CNV loss 21179565
esv3401672 CNV insertion 20981092
esv3579073 CNV loss 25503493
esv3624217 CNV loss 21293372
esv3624218 CNV loss 21293372
nsv1046258 CNV gain 25217958
nsv1113327 CNV deletion 24896259
nsv473136 CNV novel sequence insertion 20440878
nsv551923 CNV loss 21841781
nsv948136 CNV duplication 23825009
nsv948137 CNV duplication 23825009
nsv948138 CNV duplication 23825009

Variation tolerance for CPEB3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB3 Gene

Disorders for CPEB3 Gene

Relevant External Links for CPEB3

Genetic Association Database (GAD)
CPEB3
Human Genome Epidemiology (HuGE) Navigator
CPEB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB3

No disorders were found for CPEB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB3 Gene

Publications for CPEB3 Gene

  1. CPEB3 is associated with human episodic memory. (PMID: 19503753) Vogler C. … de Quervain D.J. (Front Behav Neurosci 2009) 3 4 46 64
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3. (PMID: 25066254) Tsuda K. … Muto Y. (Proteins 2014) 3 4 64
  4. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. (PMID: 22730302) Chao H.W. … Huang Y.S. (Nucleic Acids Res. 2012) 3 4 64
  5. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N. … Hoshino S. (EMBO J. 2011) 3 4 64

Products for CPEB3 Gene

Sources for CPEB3 Gene

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