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Aliases for CPEB3 Gene

Aliases for CPEB3 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 3 2 3 5
  • CPE-Binding Protein 3 3 4
  • CPE-BP3 3 4
  • HCPEB-3 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 3 3
  • KIAA0940 4

External Ids for CPEB3 Gene

Previous GeneCards Identifiers for CPEB3 Gene

  • GC10M093939
  • GC10M093472
  • GC10M093473
  • GC10M093798
  • GC10M087437

Summaries for CPEB3 Gene

GeneCards Summary for CPEB3 Gene

CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Dorso-ventral axis formation. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB3 Gene

Genomics for CPEB3 Gene

Regulatory Elements for CPEB3 Gene

Enhancers for CPEB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CPEB3 on UCSC Golden Path with GeneCards custom track

Promoters for CPEB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPEB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB3 Gene

Chromosome:
10
Start:
92,046,692 bp from pter
End:
92,291,118 bp from pter
Size:
244,427 bases
Orientation:
Minus strand

Genomic View for CPEB3 Gene

Genes around CPEB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB3 Gene

Proteins for CPEB3 Gene

  • Protein details for CPEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE35-CPEB3_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 3
    Protein Accession:
    Q8NE35
    Secondary Accessions:
    • Q5T389
    • Q9NQJ7
    • Q9Y2E9

    Protein attributes for CPEB3 Gene

    Size:
    698 amino acids
    Molecular mass:
    76014 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76784.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPEB3 Gene

    Alternative splice isoforms for CPEB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB3 Gene

Post-translational modifications for CPEB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPEB3 Gene

Antibody Products

  • Abcam antibodies for CPEB3

No data available for DME Specific Peptides for CPEB3 Gene

Domains & Families for CPEB3 Gene

Gene Families for CPEB3 Gene

Protein Domains for CPEB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NE35

UniProtKB/Swiss-Prot:

CPEB3_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB3: view

Function for CPEB3 Gene

Gene Ontology (GO) - Molecular Function for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS --
GO:0003723 RNA binding IDA 22730302
GO:0003730 mRNA 3-UTR binding ISS --
GO:0005515 protein binding IPI 20639532
genes like me logo Genes that share ontologies with CPEB3: view
genes like me logo Genes that share phenotypes with CPEB3: view

Animal Models for CPEB3 Gene

MGI Knock Outs for CPEB3:

Animal Model Products

CRISPR Products

miRNA for CPEB3 Gene

miRTarBase miRNAs that target CPEB3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB3 Gene

Localization for CPEB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB3 Gene COMPARTMENTS Subcellular localization image for CPEB3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639532
GO:0005737 cytoplasm ISS --
GO:0030014 CCR4-NOT complex IDA 21336257
GO:0030425 dendrite ISS --
GO:0043005 neuron projection ISS --
genes like me logo Genes that share ontologies with CPEB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPEB3 Gene

Pathways & Interactions for CPEB3 Gene

genes like me logo Genes that share pathways with CPEB3: view

Pathways by source for CPEB3 Gene

Gene Ontology (GO) - Biological Process for CPEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20639532
GO:0006412 translation IEA --
GO:0007616 long-term memory ISS --
GO:0017148 negative regulation of translation IDA 21336257
GO:0045727 positive regulation of translation ISS --
genes like me logo Genes that share ontologies with CPEB3: view

No data available for SIGNOR curated interactions for CPEB3 Gene

Drugs & Compounds for CPEB3 Gene

No Compound Related Data Available

Transcripts for CPEB3 Gene

Unigene Clusters for CPEB3 Gene

Cytoplasmic polyadenylation element binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB3 Gene

No ASD Table

Relevant External Links for CPEB3 Gene

GeneLoc Exon Structure for
CPEB3
ECgene alternative splicing isoforms for
CPEB3

Expression for CPEB3 Gene

mRNA expression in normal human tissues for CPEB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPEB3 Gene

This gene is overexpressed in Frontal cortex (32.3), Pancreas (20.2), Spinal cord (10.1), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPEB3 Gene



Protein tissue co-expression partners for CPEB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPEB3 Gene:

CPEB3

SOURCE GeneReport for Unigene cluster for CPEB3 Gene:

Hs.131683
genes like me logo Genes that share expression patterns with CPEB3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPEB3 Gene

Orthologs for CPEB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPEB3 34
  • 92.78 (n)
  • 95.12 (a)
CPEB3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPEB3 34
  • 93.53 (n)
  • 96.41 (a)
CPEB3 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpeb3 34
  • 90.84 (n)
  • 96.12 (a)
Cpeb3 16
Cpeb3 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPEB3 34
  • 98.91 (n)
  • 99.02 (a)
CPEB3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpeb3 34
  • 90.9 (n)
  • 96.4 (a)
oppossum
(Monodelphis domestica)
Mammalia CPEB3 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB3 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPEB3 34
  • 83.16 (n)
  • 90.47 (a)
CPEB3 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPEB3 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb3 34
  • 78.27 (n)
  • 85.39 (a)
zebrafish
(Danio rerio)
Actinopterygii cpeb3 34
  • 74.03 (n)
  • 79.68 (a)
cpeb3 35
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta orb2 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 35
  • 33 (a)
ManyToMany
cpb-2 35
  • 29 (a)
ManyToMany
fog-1 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
ManyToMany
-- 35
  • 88 (a)
ManyToMany
Species where no ortholog for CPEB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB3 Gene

ENSEMBL:
Gene Tree for CPEB3 (if available)
TreeFam:
Gene Tree for CPEB3 (if available)

Paralogs for CPEB3 Gene

Paralogs for CPEB3 Gene

(5) SIMAP similar genes for CPEB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CPEB3: view

Variants for CPEB3 Gene

Sequence variations from dbSNP and Humsavar for CPEB3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs17853616 - 92,239,381(+) GGTCC(A/G)GAAAG reference, missense
rs1935864 -- 92,072,844(-) GCATA(C/T)TTGAG intron-variant
rs1935865 -- 92,114,732(-) GTTCC(A/G)CCACT intron-variant
rs1935866 -- 92,147,749(+) ACAGG(A/T)GGGCA intron-variant
rs1971471 -- 92,236,671(-) CCCGG(G/T)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB3 Gene

Variant ID Type Subtype PubMed ID
esv2664459 CNV deletion 23128226
esv2671036 CNV deletion 23128226
esv2739562 CNV deletion 23290073
esv2761614 CNV loss 21179565
esv3401672 CNV insertion 20981092
esv3579073 CNV loss 25503493
esv3624217 CNV loss 21293372
esv3624218 CNV loss 21293372
nsv1046258 CNV gain 25217958
nsv1113327 CNV deletion 24896259
nsv473136 CNV novel sequence insertion 20440878
nsv551923 CNV loss 21841781
nsv948136 CNV duplication 23825009
nsv948137 CNV duplication 23825009
nsv948138 CNV duplication 23825009

Variation tolerance for CPEB3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB3 Gene

Disorders for CPEB3 Gene

Relevant External Links for CPEB3

Genetic Association Database (GAD)
CPEB3
Human Genome Epidemiology (HuGE) Navigator
CPEB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB3

No disorders were found for CPEB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB3 Gene

Publications for CPEB3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. CPEB3 is associated with human episodic memory. (PMID: 19503753) Vogler C. … de Quervain D.J. (Front Behav Neurosci 2009) 3 46 65
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65

Products for CPEB3 Gene

Sources for CPEB3 Gene

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