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Aliases for CPEB2 Gene

Aliases for CPEB2 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 2 2 3 5
  • CPE-Binding Protein 2 3 4
  • CPE-BP2 3 4
  • HCPEB-2 3 4
  • CPEB-2 3

External Ids for CPEB2 Gene

Previous GeneCards Identifiers for CPEB2 Gene

  • GC04P014707
  • GC04P014756
  • GC04P014681
  • GC04P014355

Summaries for CPEB2 Gene

Entrez Gene Summary for CPEB2 Gene

  • The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPEB2 Gene

CPEB2 (Cytoplasmic Polyadenylation Element Binding Protein 2) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation and Oocyte meiosis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPEB3.

UniProtKB/Swiss-Prot for CPEB2 Gene

  • May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB2 Gene

Genomics for CPEB2 Gene

Regulatory Elements for CPEB2 Gene

Enhancers for CPEB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPEB2 on UCSC Golden Path with GeneCards custom track

Promoters for CPEB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CPEB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPEB2 Gene

Chromosome:
4
Start:
15,002,451 bp from pter
End:
15,070,153 bp from pter
Size:
67,703 bases
Orientation:
Plus strand

Genomic View for CPEB2 Gene

Genes around CPEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB2 Gene

Proteins for CPEB2 Gene

  • Protein details for CPEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5Q1-CPEB2_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 2
    Protein Accession:
    Q7Z5Q1
    Secondary Accessions:
    • E7EPM3
    • F5H160
    • Q3B8N6
    • Q3MI89
    • Q3MI90
    • Q3MI92
    • Q7Z5Q0

    Protein attributes for CPEB2 Gene

    Size:
    589 amino acids
    Molecular mass:
    64944 Da
    Quaternary structure:
    • Interacts with PAPD4/GLD2.

    Alternative splice isoforms for CPEB2 Gene

neXtProt entry for CPEB2 Gene

Proteomics data for CPEB2 Gene at MOPED

Post-translational modifications for CPEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB2 Gene

Domains & Families for CPEB2 Gene

Gene Families for CPEB2 Gene

Protein Domains for CPEB2 Gene

Suggested Antigen Peptide Sequences for CPEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5Q1

UniProtKB/Swiss-Prot:

CPEB2_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB2: view

Function for CPEB2 Gene

Molecular function for CPEB2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).

Gene Ontology (GO) - Molecular Function for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0005095 GTPase inhibitor activity ISS --
genes like me logo Genes that share ontologies with CPEB2: view

Phenotypes for CPEB2 Gene

genes like me logo Genes that share phenotypes with CPEB2: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPEB2 Gene

Localization for CPEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB2 Gene COMPARTMENTS Subcellular localization image for CPEB2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CPEB2 Gene

Pathways & Interactions for CPEB2 Gene

genes like me logo Genes that share pathways with CPEB2: view

Pathways by source for CPEB2 Gene

Interacting Proteins for CPEB2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000443985%0d%0a9606.ENSP00000358815%0d%0a9606.ENSP00000358795%0d%0a9606.ENSP00000391723%0d%0a9606.ENSP00000338173%0d%0a
Selected Interacting proteins: ENSP00000443985 for CPEB2 Gene via STRING

Gene Ontology (GO) - Biological Process for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0034599 cellular response to oxidative stress ISS --
GO:0071456 cellular response to hypoxia IDA 18752464
GO:2000766 negative regulation of cytoplasmic translation IMP 18752464
genes like me logo Genes that share ontologies with CPEB2: view

No data available for SIGNOR curated interactions for CPEB2 Gene

Drugs & Compounds for CPEB2 Gene

No Compound Related Data Available

Transcripts for CPEB2 Gene

Unigene Clusters for CPEB2 Gene

Cytoplasmic polyadenylation element binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for CPEB2 Gene

GeneLoc Exon Structure for
CPEB2
ECgene alternative splicing isoforms for
CPEB2

Expression for CPEB2 Gene

mRNA expression in normal human tissues for CPEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPEB2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPEB2 Gene



SOURCE GeneReport for Unigene cluster for CPEB2 Gene Hs.656937

genes like me logo Genes that share expression patterns with CPEB2: view

Protein tissue co-expression partners for CPEB2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPEB2 Gene

Orthologs for CPEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPEB2 35
  • 93.2 (n)
  • 93.6 (a)
CPEB2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPEB2 35
  • 95.78 (n)
  • 96.99 (a)
CPEB2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpeb2 35
  • 88.09 (n)
  • 88.61 (a)
Cpeb2 16
Cpeb2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPEB2 35
  • 97.68 (n)
  • 96.85 (a)
CPEB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpeb2 35
  • 91.37 (n)
  • 95.48 (a)
oppossum
(Monodelphis domestica)
Mammalia CPEB2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPEB2 35
  • 90.04 (n)
  • 99.29 (a)
CPEB2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7189 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7084 35
zebrafish
(Danio rerio)
Actinopterygii cpeb2 35
  • 70.51 (n)
  • 78.54 (a)
CPEB2 36
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta orb2 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 36
  • 31 (a)
ManyToMany
cpb-2 36
  • 28 (a)
ManyToMany
fog-1 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 80 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
Species with no ortholog for CPEB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB2 Gene

ENSEMBL:
Gene Tree for CPEB2 (if available)
TreeFam:
Gene Tree for CPEB2 (if available)

Paralogs for CPEB2 Gene

Paralogs for CPEB2 Gene

(5) SIMAP similar genes for CPEB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB2: view

Variants for CPEB2 Gene

Sequence variations from dbSNP and Humsavar for CPEB2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs367900636 -- 15,004,107(+) AGCGT(G/T)CCGAC reference, synonymous-codon
rs370002891 -- 15,004,052(+) CCCGG(C/T)CTTCT reference, missense
rs201682122 -- 15,004,132(+) GCGGC(G/T)GCTTC reference, missense
rs191240869 -- 15,004,214(+) CCCGC(C/T)GCCCG reference, missense
rs199765976 -- 15,004,074(+) TCGCC(C/T)GTGTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CPEB2 Gene

Variant ID Type Subtype PubMed ID
nsv461280 CNV Loss 19166990
nsv829868 CNV Gain 17160897
esv29275 CNV Loss 19812545
esv2437263 CNV Deletion 19546169
nsv518661 CNV Loss 19592680
nsv878711 CNV Loss 21882294

Variation tolerance for CPEB2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.16; 98.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPEB2 Gene

Disorders for CPEB2 Gene

Relevant External Links for CPEB2

Genetic Association Database (GAD)
CPEB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB2

No disorders were found for CPEB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB2 Gene

Publications for CPEB2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) HAogele S. … Katschinski D.M. (Biochem. J. 2009) 3 23
  3. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3
  4. The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer. (PMID: 26304115) Johnson R.M. … Park M.A. (J. Biol. Chem. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CPEB2 Gene

Sources for CPEB2 Gene

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