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Aliases for CPEB2 Gene

Aliases for CPEB2 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 2 2 3
  • CPE-Binding Protein 2 3 4
  • CPE-BP2 3 4
  • HCPEB-2 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 2 3
  • CPEB-2 3

External Ids for CPEB2 Gene

Previous GeneCards Identifiers for CPEB2 Gene

  • GC04P014707
  • GC04P014756
  • GC04P014681
  • GC04P014355

Summaries for CPEB2 Gene

Entrez Gene Summary for CPEB2 Gene

  • The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPEB2 Gene

CPEB2 (Cytoplasmic Polyadenylation Element Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CPEB3.

UniProtKB/Swiss-Prot for CPEB2 Gene

  • May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB2 Gene

Genomics for CPEB2 Gene

Regulatory Elements for CPEB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPEB2 Gene

15,002,674 bp from pter
15,070,153 bp from pter
67,480 bases
Plus strand

Genomic View for CPEB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB2 Gene

Proteins for CPEB2 Gene

  • Protein details for CPEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • E7EPM3
    • F5H160
    • Q3B8N6
    • Q3MI89
    • Q3MI90
    • Q3MI92
    • Q7Z5Q0

    Protein attributes for CPEB2 Gene

    589 amino acids
    Molecular mass:
    64944 Da
    Quaternary structure:
    • Interacts with PAPD4/GLD2.

    Alternative splice isoforms for CPEB2 Gene

neXtProt entry for CPEB2 Gene

Proteomics data for CPEB2 Gene at MOPED

Post-translational modifications for CPEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CPEB2 Gene

Domains for CPEB2 Gene

Gene Families for CPEB2 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for CPEB2 Gene

Suggested Antigen Peptide Sequences for CPEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z5Q1
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB2: view

Function for CPEB2 Gene

Molecular function for CPEB2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity).

Gene Ontology (GO) - Molecular Function for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS --
GO:0003676 nucleic acid binding --
GO:0005095 GTPase inhibitor activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CPEB2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPEB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CPEB2 Gene

Localization for CPEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB2 Gene


Subcellular locations from

Jensen Localization Image for CPEB2 Gene COMPARTMENTS Subcellular localization image for CPEB2 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639532
GO:0005737 cytoplasm IDA 20639532
GO:0005844 polysome IEA --
GO:1990124 messenger ribonucleoprotein complex ISS --
genes like me logo Genes that share ontologies with CPEB2: view

Pathways for CPEB2 Gene

SuperPathways for CPEB2 Gene

No Data Available

Interacting Proteins for CPEB2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000443985 for CPEB2 Gene via STRING

Gene Ontology (GO) - Biological Process for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032869 cellular response to insulin stimulus IDA 18752464
GO:0033125 obsolete negative regulation of GTP catabolic process --
GO:0034260 negative regulation of GTPase activity ISS --
GO:0034599 cellular response to oxidative stress ISS --
GO:0045900 negative regulation of translational elongation --
genes like me logo Genes that share ontologies with CPEB2: view

No data available for Pathways by source for CPEB2 Gene

Transcripts for CPEB2 Gene

Unigene Clusters for CPEB2 Gene

Cytoplasmic polyadenylation element binding protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPEB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -

Relevant External Links for CPEB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPEB2 Gene

mRNA expression in normal human tissues for CPEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CPEB2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPEB2 Gene

SOURCE GeneReport for Unigene cluster for CPEB2 Gene Hs.656937

genes like me logo Genes that share expressions with CPEB2: view

Expression partners for CPEB2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPEB2 Gene

Orthologs for CPEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPEB2 35
  • 93.2 (n)
  • 93.6 (a)
CPEB2 36
  • 97 (a)
(Canis familiaris)
Mammalia CPEB2 35
  • 95.78 (n)
  • 96.99 (a)
CPEB2 36
  • 99 (a)
(Mus musculus)
Mammalia Cpeb2 35
  • 88.09 (n)
  • 88.61 (a)
Cpeb2 16
Cpeb2 36
  • 92 (a)
(Pan troglodytes)
Mammalia CPEB2 35
  • 97.68 (n)
  • 96.85 (a)
CPEB2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cpeb2 35
  • 91.37 (n)
  • 95.48 (a)
(Monodelphis domestica)
Mammalia CPEB2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia CPEB2 36
  • 99 (a)
(Gallus gallus)
Aves CPEB2 35
  • 90.04 (n)
  • 99.29 (a)
CPEB2 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
-- 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7189 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7084 35
(Danio rerio)
Actinopterygii cpeb2 35
  • 70.51 (n)
  • 78.54 (a)
CPEB2 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta orb2 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea cpb-1 36
  • 31 (a)
cpb-2 36
  • 28 (a)
fog-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 80 (a)
-- 36
  • 90 (a)
Species with no ortholog for CPEB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB2 Gene

Gene Tree for CPEB2 (if available)
Gene Tree for CPEB2 (if available)

Paralogs for CPEB2 Gene

Paralogs for CPEB2 Gene

Selected SIMAP similar genes for CPEB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB2: view

Variants for CPEB2 Gene

Sequence variations from dbSNP and Humsavar for CPEB2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs967090 -- 15,041,654(+) CACCT(C/T)GGCCT intron-variant
rs967364 -- 15,041,745(+) GTGTG(C/T)ACTTT intron-variant
rs968365 -- 15,042,115(+) TACCA(A/G)TCTGT intron-variant
rs987399 -- 15,058,363(+) ACTGA(A/G)ATTTG intron-variant
rs1349999 -- 15,058,364(+) CTGAA(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB2 Gene

Variant ID Type Subtype PubMed ID
nsv461280 CNV Loss 19166990
nsv829868 CNV Gain 17160897
esv29275 CNV Loss 19812545
esv2437263 CNV Deletion 19546169
nsv518661 CNV Loss 19592680
nsv878711 CNV Loss 21882294

Relevant External Links for CPEB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB2 Gene

Disorders for CPEB2 Gene

Relevant External Links for CPEB2

Genetic Association Database (GAD)

No disorders were found for CPEB2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CPEB2 Gene

Publications for CPEB2 Gene

  1. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) HAogele S. … Katschinski D.M. (Biochem. J. 2009) 3 23
  2. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. (PMID: 20639532) Peng S.C. … Huang Y.S. (Nucleic Acids Res. 2010) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for CPEB2 Gene

Sources for CPEB2 Gene

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