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Aliases for CPEB2 Gene

Aliases for CPEB2 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 2 2 3 5
  • CPE-Binding Protein 2 3 4
  • CPE-BP2 3 4
  • HCPEB-2 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 2 3
  • CPEB-2 3

External Ids for CPEB2 Gene

Previous GeneCards Identifiers for CPEB2 Gene

  • GC04P014707
  • GC04P014756
  • GC04P014681
  • GC04P014355

Summaries for CPEB2 Gene

Entrez Gene Summary for CPEB2 Gene

  • The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPEB2 Gene

CPEB2 (Cytoplasmic Polyadenylation Element Binding Protein 2) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation and Oocyte meiosis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPEB4.

UniProtKB/Swiss-Prot for CPEB2 Gene

  • May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB2 Gene

Genomics for CPEB2 Gene

Regulatory Elements for CPEB2 Gene

Enhancers for CPEB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G015000 1.4 ENCODE dbSUPER 10.3 +1.2 1226 6.1 HDGF FOXA2 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 CPEB2 LINC00504 CPEB2-AS1 GC04M015093 RN7SKP170
GH04G014855 1.6 FANTOM5 Ensembl ENCODE 5 -146.0 -146005 2.5 PKNOX1 ATF1 ZNF766 CBX5 FOS JUNB TBX21 SMARCA4 NBN NR2C1 CPEB2 LINC00504 ENSG00000202449
GH04G015231 1.3 FANTOM5 Ensembl ENCODE 3.7 +231.4 231362 4.4 CTCF RAD21 ZBTB40 YY1 HIC1 POLR2A ZNF143 SMC3 FOS MAFK C1QTNF7 LOC101929095 CPEB2 BST1 FBXL5 LOC105374501
GH04G015129 0.7 dbSUPER 6.8 +129.8 129838 5.1 GTF2F1 MAX CEBPG RAD21 SCRT2 RCOR1 DEK NFE2L2 TCF7L2 ELK4 LINC00504 CPEB2 LOC105374501 C1QTNF7
GH04G015106 0.6 ENCODE 7.9 +104.4 104370 1.6 JUND ATF1 ATF3 CREB1 HNF4A ATF2 CPEB2 PIR36892 RN7SKP170 GC04M015093
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPEB2 on UCSC Golden Path with GeneCards custom track

Promoters for CPEB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166138 1449 5801 HDGF FOXA2 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for CPEB2 Gene

Chromosome:
4
Start:
15,002,451 bp from pter
End:
15,070,153 bp from pter
Size:
67,703 bases
Orientation:
Plus strand

Genomic View for CPEB2 Gene

Genes around CPEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB2 Gene

Proteins for CPEB2 Gene

  • Protein details for CPEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5Q1-CPEB2_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 2
    Protein Accession:
    Q7Z5Q1
    Secondary Accessions:
    • E7EPM3
    • F5H160
    • Q3B8N6
    • Q3MI89
    • Q3MI90
    • Q3MI92
    • Q7Z5Q0

    Protein attributes for CPEB2 Gene

    Size:
    589 amino acids
    Molecular mass:
    64944 Da
    Quaternary structure:
    • Interacts with PAPD4/GLD2.

    Alternative splice isoforms for CPEB2 Gene

neXtProt entry for CPEB2 Gene

Post-translational modifications for CPEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB2 Gene

Domains & Families for CPEB2 Gene

Gene Families for CPEB2 Gene

Suggested Antigen Peptide Sequences for CPEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5Q1

UniProtKB/Swiss-Prot:

CPEB2_HUMAN :
  • Belongs to the RRM CPEB family.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB2: view

Function for CPEB2 Gene

Molecular function for CPEB2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).

Gene Ontology (GO) - Molecular Function for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, nucleic acid binding ISS,IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005095 GTPase inhibitor activity ISS --
genes like me logo Genes that share ontologies with CPEB2: view
genes like me logo Genes that share phenotypes with CPEB2: view

Animal Models for CPEB2 Gene

MGI Knock Outs for CPEB2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB2 Gene

Localization for CPEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20639532
GO:0005737 cytoplasm IEA,IDA 20639532
GO:0043005 neuron projection IBA --
GO:0045202 synapse IBA --
GO:1990124 messenger ribonucleoprotein complex IBA,ISS --
genes like me logo Genes that share ontologies with CPEB2: view

Pathways & Interactions for CPEB2 Gene

genes like me logo Genes that share pathways with CPEB2: view

Pathways by source for CPEB2 Gene

Interacting Proteins for CPEB2 Gene

Gene Ontology (GO) - Biological Process for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006417 regulation of translation IEA --
GO:0032869 cellular response to insulin stimulus IDA 18752464
GO:0034260 negative regulation of GTPase activity ISS --
GO:0034599 cellular response to oxidative stress ISS --
genes like me logo Genes that share ontologies with CPEB2: view

No data available for SIGNOR curated interactions for CPEB2 Gene

Drugs & Compounds for CPEB2 Gene

No Compound Related Data Available

Transcripts for CPEB2 Gene

Unigene Clusters for CPEB2 Gene

Cytoplasmic polyadenylation element binding protein 2:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for CPEB2 Gene

GeneLoc Exon Structure for
CPEB2
ECgene alternative splicing isoforms for
CPEB2

Expression for CPEB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPEB2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPEB2 Gene



Protein tissue co-expression partners for CPEB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPEB2 Gene:

CPEB2

SOURCE GeneReport for Unigene cluster for CPEB2 Gene:

Hs.656937
genes like me logo Genes that share expression patterns with CPEB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPEB2 Gene

Orthologs for CPEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPEB2 34 35
  • 97.68 (n)
dog
(Canis familiaris)
Mammalia CPEB2 34 35
  • 95.78 (n)
oppossum
(Monodelphis domestica)
Mammalia CPEB2 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB2 34 35
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia Cpeb2 34
  • 91.37 (n)
mouse
(Mus musculus)
Mammalia Cpeb2 34 16 35
  • 88.09 (n)
chicken
(Gallus gallus)
Aves CPEB2 34 35
  • 90.04 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 97 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7189 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7084 34
zebrafish
(Danio rerio)
Actinopterygii CPEB2 35
  • 89 (a)
OneToOne
cpeb2 34
  • 70.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta orb2 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 35
  • 31 (a)
ManyToMany
cpb-2 35
  • 28 (a)
ManyToMany
fog-1 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 90 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
Species where no ortholog for CPEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB2 Gene

ENSEMBL:
Gene Tree for CPEB2 (if available)
TreeFam:
Gene Tree for CPEB2 (if available)

Paralogs for CPEB2 Gene

Paralogs for CPEB2 Gene

(5) SIMAP similar genes for CPEB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CPEB2: view

Variants for CPEB2 Gene

Sequence variations from dbSNP and Humsavar for CPEB2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000140067 -- 15,060,325(+) CAAAA(C/G)AGAGA intron-variant
rs1000149028 -- 15,003,759(+) CCCCA(-/GGAGGCGGAGGG)GGAGG upstream-variant-2KB, cds-indel
rs1000176224 -- 15,064,603(+) ATGAG(A/C)AAGAA intron-variant
rs1000197408 -- 15,011,693(+) CATAT(A/G)TTTTA intron-variant
rs1000246778 -- 15,023,599(+) TTAAC(-/TTTT)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB2 Gene

Variant ID Type Subtype PubMed ID
dgv8976n54 CNV gain+loss 21841781
dgv8977n54 CNV loss 21841781
dgv8978n54 CNV loss 21841781
esv2437263 CNV deletion 19546169
esv29275 CNV loss 19812545
esv3563459 CNV deletion 23714750
nsv1073312 CNV deletion 25765185
nsv1145026 CNV deletion 24896259
nsv461280 CNV loss 19166990
nsv518661 CNV loss 19592680
nsv593757 CNV loss 21841781
nsv593758 CNV gain 21841781
nsv593759 CNV loss 21841781
nsv593760 CNV gain 21841781
nsv829868 CNV gain 17160897

Variation tolerance for CPEB2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.16; 98.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB2 Gene

Disorders for CPEB2 Gene

Relevant External Links for CPEB2

Genetic Association Database (GAD)
CPEB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB2

No disorders were found for CPEB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB2 Gene

Publications for CPEB2 Gene

  1. Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle. (PMID: 26398195) GiangarrA V. … Mendez R. (PLoS ONE 2015) 3 4 64
  2. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) HAogele S. … Katschinski D.M. (Biochem. J. 2009) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y. … Uesugi S. (Biol. Reprod. 2003) 2 3 64
  5. LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis. (PMID: 28358263) Wang Q. … Hao S. (Cell Cycle 2017) 3 64

Products for CPEB2 Gene

Sources for CPEB2 Gene

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