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Aliases for CPEB1 Gene

Aliases for CPEB1 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 1 2 3 5
  • CPE-Binding Protein 1 3 4
  • CPE-BP1 3 4
  • HCPEB-1 3 4
  • H-CPEB 3 4
  • CPEB 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 1 3
  • CPEB-1 3

External Ids for CPEB1 Gene

Previous GeneCards Identifiers for CPEB1 Gene

  • GC15M079015
  • GC15M076145
  • GC15M080796
  • GC15M080939
  • GC15M080940
  • GC15M081009
  • GC15M083211
  • GC15M059482

Summaries for CPEB1 Gene

Entrez Gene Summary for CPEB1 Gene

  • This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CPEB1 Gene

CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CPEB1 include Kuru and Choline Deficiency Disease. Among its related pathways are Oocyte meiosis and Aurora A signaling. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000260836.

UniProtKB/Swiss-Prot for CPEB1 Gene

  • Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Gene Wiki entry for CPEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB1 Gene

Genomics for CPEB1 Gene

Regulatory Elements for CPEB1 Gene

Enhancers for CPEB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F083010 1.1 ENCODE 21.5 -362.6 -362599 2.8 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK C15orf40 FAM103A1 SNHG21 RPL9P9 CPEB1 CPEB1-AS1 EFL1 AP3B2 WHAMM ENSG00000260579
GH15F082803 1.4 FANTOM5 Ensembl ENCODE 12.7 -159.8 -159751 9.8 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 WHAMM AP3B2 FAM103A1 CPEB1-AS1 CPEB1 SCARNA15 EFL1 HDGFRP3 GOLGA6L9 C15orf40
GH15F082081 0.6 ENCODE 12.3 +566.3 566268 1.2 ZNF263 CTCF MAX REST ZNF2 RAD21 JUND ZNF157 SMC3 FOS CPEB1 CPEB1-AS1 AP3B2 SNHG21 MEX3B LINC01583
GH15F082708 0.2 ENCODE 11 -60.5 -60471 2.0 HDGF PKNOX1 ZNF133 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 KLF7 AP3B2 LINC01583 SAXO2 C15orf40 SNHG21 CPEB1 CPEB1-AS1 EFL1 PIR57194
GH15F082260 0.6 ENCODE 10 +386.5 386508 3.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF207 FOS KLF13 SP3 SAXO2 CSPG4P10 HDGFRP3 CPEB1 AP3B2 EFL1 GC15M082251
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CPEB1 on UCSC Golden Path with GeneCards custom track

Promoters for CPEB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000412467 1061 1201 ATF1 CREB3L1 SIN3A GLIS2 ZNF202 SP3 REST SMARCA4 GLIS1 KDM1A

Genomic Location for CPEB1 Gene

Chromosome:
15
Start:
82,543,201 bp from pter
End:
82,648,861 bp from pter
Size:
105,661 bases
Orientation:
Minus strand

Genomic View for CPEB1 Gene

Genes around CPEB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB1 Gene

Proteins for CPEB1 Gene

  • Protein details for CPEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZB8-CPEB1_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 1
    Protein Accession:
    Q9BZB8
    Secondary Accessions:
    • B7Z6C6
    • Q86W46
    • Q8IV41
    • Q9BZB7
    • Q9H8V5

    Protein attributes for CPEB1 Gene

    Size:
    566 amino acids
    Molecular mass:
    62595 Da
    Quaternary structure:
    • Interacts with kinesin, dynein, APLP1, APLP2, PAPD4/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CPEB1 Gene

    Alternative splice isoforms for CPEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB1 Gene

Post-translational modifications for CPEB1 Gene

  • Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CPEB1 (CPEB)
  • Cloud-Clone Corp. Antibodies for CPEB1

No data available for DME Specific Peptides for CPEB1 Gene

Domains & Families for CPEB1 Gene

Suggested Antigen Peptide Sequences for CPEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZB8

UniProtKB/Swiss-Prot:

CPEB1_HUMAN :
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
  • Belongs to the RRM CPEB family.
Domain:
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB1: view

No data available for Gene Families for CPEB1 Gene

Function for CPEB1 Gene

Molecular function for CPEB1 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Gene Ontology (GO) - Molecular Function for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS,IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding IBA --
genes like me logo Genes that share ontologies with CPEB1: view
genes like me logo Genes that share phenotypes with CPEB1: view

Animal Models for CPEB1 Gene

MGI Knock Outs for CPEB1:

Animal Model Products

miRNA for CPEB1 Gene

miRTarBase miRNAs that target CPEB1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB1 Gene

Localization for CPEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB1 Gene

Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB1 Gene COMPARTMENTS Subcellular localization image for CPEB1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS,IDA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CPEB1: view

Pathways & Interactions for CPEB1 Gene

genes like me logo Genes that share pathways with CPEB1: view

Pathways by source for CPEB1 Gene

1 Cell Signaling Technology pathway for CPEB1 Gene
1 BioSystems pathway for CPEB1 Gene

Interacting Proteins for CPEB1 Gene

Gene Ontology (GO) - Biological Process for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006412 translation IEA --
GO:0006417 regulation of translation IEA --
GO:0032869 cellular response to insulin stimulus IDA 18752464
GO:0071230 cellular response to amino acid stimulus ISS --
genes like me logo Genes that share ontologies with CPEB1: view

No data available for SIGNOR curated interactions for CPEB1 Gene

Drugs & Compounds for CPEB1 Gene

(5) Drugs for CPEB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CPEB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPEB1: view

Transcripts for CPEB1 Gene

Unigene Clusters for CPEB1 Gene

Cytoplasmic polyadenylation element binding protein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB1 Gene

No ASD Table

Relevant External Links for CPEB1 Gene

GeneLoc Exon Structure for
CPEB1
ECgene alternative splicing isoforms for
CPEB1

Expression for CPEB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPEB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPEB1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for CPEB1 Gene

This gene is overexpressed in Heart (34.4) and Neutrophil (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPEB1 Gene



Protein tissue co-expression partners for CPEB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPEB1 Gene:

CPEB1

SOURCE GeneReport for Unigene cluster for CPEB1 Gene:

Hs.547988

mRNA Expression by UniProt/SwissProt for CPEB1 Gene:

Q9BZB8-CPEB1_HUMAN
Tissue specificity: Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.
genes like me logo Genes that share expression patterns with CPEB1: view

Primer Products

Orthologs for CPEB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB1 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
CPEB1 34
  • 92.58 (n)
dog
(Canis familiaris)
Mammalia CPEB1 34
  • 94 (n)
-- 35
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cpeb1 34 16 35
  • 92.03 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cpeb1 34
  • 91.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 85 (a)
OneToMany
CPEB1 34
  • 80.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb1 34
  • 74.81 (n)
Str.5854 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.984 34
zebrafish
(Danio rerio)
Actinopterygii cpeb1b 34 35
  • 68.14 (n)
cpeb1a 35 35
  • 55 (a)
ManyToMany
zorba 34
fruit fly
(Drosophila melanogaster)
Insecta orb 36 35
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea cpb-3 36 35
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4588 34
Species where no ortholog for CPEB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB1 Gene

ENSEMBL:
Gene Tree for CPEB1 (if available)
TreeFam:
Gene Tree for CPEB1 (if available)

Paralogs for CPEB1 Gene

Paralogs for CPEB1 Gene

genes like me logo Genes that share paralogs with CPEB1: view

Variants for CPEB1 Gene

Sequence variations from dbSNP and Humsavar for CPEB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152286 -- 82,616,214(+) tgaga(G/T)catga intron-variant
rs10162807 -- 82,620,430(+) aaaaa(A/G)aaaaa intron-variant
rs10163167 -- 82,560,645(+) ACCTC(A/G)GCCTC intron-variant
rs10220739 -- 82,643,497(+) ggtgg(C/T)gcgtg intron-variant
rs10400906 -- 82,628,387(+) acaat(C/T)tgata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB1 Gene

Variant ID Type Subtype PubMed ID
dgv2637n100 CNV gain 25217958
esv1651554 CNV deletion 17803354
esv21531 CNV gain+loss 19812545
esv2160515 CNV deletion 18987734
esv22027 CNV gain+loss 19812545
esv2449307 CNV deletion 19546169
esv2566465 CNV deletion 19546169
esv2671639 CNV deletion 23128226
esv2674021 CNV deletion 23128226
esv2749956 CNV deletion 23290073
esv2749957 CNV deletion 23290073
esv33057 CNV gain 17666407
esv34318 CNV loss 17911159
esv3552762 CNV deletion 23714750
esv3637058 CNV gain 21293372
esv3637059 CNV loss 21293372
esv3637060 CNV loss 21293372
esv4952 CNV loss 18987735
esv5568 CNV loss 19470904
nsv1035899 CNV gain 25217958
nsv1069878 CNV deletion 25765185
nsv1069879 CNV deletion 25765185
nsv1069880 CNV deletion 25765185
nsv1116092 CNV deletion 24896259
nsv1120052 OTHER inversion 24896259
nsv1122985 CNV deletion 24896259
nsv1126402 CNV deletion 24896259
nsv1131093 CNV deletion 24896259
nsv1640 CNV insertion 18451855
nsv472570 CNV novel sequence insertion 20440878
nsv483125 CNV loss 15286789
nsv817702 CNV loss 17921354
nsv833071 CNV gain 17160897
nsv952012 CNV deletion 24416366

Variation tolerance for CPEB1 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.77; 93.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB1 Gene

Human Gene Mutation Database (HGMD)
CPEB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB1 Gene

Disorders for CPEB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPEB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kuru
  • kuru, susceptibility to
choline deficiency disease
  • choline deficiency
- elite association - COSMIC cancer census association via MalaCards
Search CPEB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPEB1

Genetic Association Database (GAD)
CPEB1
Human Genome Epidemiology (HuGE) Navigator
CPEB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB1
genes like me logo Genes that share disorders with CPEB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPEB1 Gene

Publications for CPEB1 Gene

  1. Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein. (PMID: 11223249) Welk J.F. … MacNicol A.M. (Gene 2001) 2 3 4 64
  2. The C-Terminal region of cytoplasmic polyadenylation element binding protein is a ZZ domain with potential for protein-protein interactions. (PMID: 23500490) Merkel D.J. … Lee B.M. (J. Mol. Biol. 2013) 3 4 64
  3. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D. … Houlston R.S. (Nat. Genet. 2010) 3 46 64
  4. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) HAogele S. … Katschinski D.M. (Biochem. J. 2009) 3 22 64
  5. Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development. (PMID: 19161537) Hansen C.N. … Norrild B. (APMIS 2009) 3 22 64

Products for CPEB1 Gene

Sources for CPEB1 Gene

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