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Aliases for CPEB1 Gene

Aliases for CPEB1 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 1 2 3
  • CPE-Binding Protein 1 3 4
  • CPE-BP1 3 4
  • HCPEB-1 3 4
  • H-CPEB 3 4
  • CPEB 3 4
  • CPEB-1 3

External Ids for CPEB1 Gene

Previous GeneCards Identifiers for CPEB1 Gene

  • GC15M079015
  • GC15M076145
  • GC15M080796
  • GC15M080939
  • GC15M080940
  • GC15M081009
  • GC15M083211
  • GC15M059482

Summaries for CPEB1 Gene

Entrez Gene Summary for CPEB1 Gene

  • This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CPEB1 Gene

CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1) is a Protein Coding gene. Among its related pathways are Translational Control and Aurora A signaling. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPEB2.

UniProtKB/Swiss-Prot for CPEB1 Gene

  • Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Gene Wiki entry for CPEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB1 Gene

Genomics for CPEB1 Gene

Regulatory Elements for CPEB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPEB1 Gene

Chromosome:
15
Start:
82,543,201 bp from pter
End:
82,648,861 bp from pter
Size:
105,661 bases
Orientation:
Minus strand

Genomic View for CPEB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB1 Gene

Proteins for CPEB1 Gene

  • Protein details for CPEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZB8-CPEB1_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 1
    Protein Accession:
    Q9BZB8
    Secondary Accessions:
    • B7Z6C6
    • Q86W46
    • Q8IV41
    • Q9BZB7
    • Q9H8V5

    Protein attributes for CPEB1 Gene

    Size:
    566 amino acids
    Molecular mass:
    62595 Da
    Quaternary structure:
    • Interacts with kinesin, dynein, APLP1, APLP2, PAPD4/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CPEB1 Gene

    Alternative splice isoforms for CPEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB1 Gene

Proteomics data for CPEB1 Gene at MOPED

Post-translational modifications for CPEB1 Gene

  • Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CPEB1 (CPEB)

No data available for DME Specific Peptides for CPEB1 Gene

Domains & Families for CPEB1 Gene

Protein Domains for CPEB1 Gene

Suggested Antigen Peptide Sequences for CPEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZB8

UniProtKB/Swiss-Prot:

CPEB1_HUMAN :
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
  • Belongs to the RRM CPEB family.
Domain:
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB1: view

No data available for Gene Families for CPEB1 Gene

Function for CPEB1 Gene

Molecular function for CPEB1 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Gene Ontology (GO) - Molecular Function for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000900 translation repressor activity, nucleic acid binding ISS --
GO:0003676 nucleic acid binding --
GO:0003730 mRNA 3-UTR binding IBA --
GO:0008135 translation factor activity, RNA binding IBA --
genes like me logo Genes that share ontologies with CPEB1: view
genes like me logo Genes that share phenotypes with CPEB1: view

Animal Models for CPEB1 Gene

MGI Knock Outs for CPEB1:

Animal Model Products

CRISPR Products

miRNA for CPEB1 Gene

miRTarBase miRNAs that target CPEB1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPEB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CPEB1 Gene

Localization for CPEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB1 Gene

Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPEB1 Gene COMPARTMENTS Subcellular localization image for CPEB1 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CPEB1: view

Pathways & Interactions for CPEB1 Gene

genes like me logo Genes that share pathways with CPEB1: view

Pathways by source for CPEB1 Gene

1 Cell Signaling Technology pathway for CPEB1 Gene
1 BioSystems pathway for CPEB1 Gene

Interacting Proteins for CPEB1 Gene

Selected Interacting proteins: Q9BZB8-CPEB1_HUMAN for CPEB1 Gene via I2D

Symbol External ID(s) Details
DYNLRB1
KIF1B

Gene Ontology (GO) - Biological Process for CPEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006412 translation IBA --
GO:0032869 cellular response to insulin stimulus IDA 18752464
GO:0071230 cellular response to amino acid stimulus ISS --
GO:0071456 cellular response to hypoxia IDA 18752464
genes like me logo Genes that share ontologies with CPEB1: view

No data available for SIGNOR curated interactions for CPEB1 Gene

Drugs & Compounds for CPEB1 Gene

(4) Drugs for CPEB1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Calcium Nutra 0
serine Nutra 420
threonine Nutra 16

(2) Additional Compounds for CPEB1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with CPEB1: view

Transcripts for CPEB1 Gene

Unigene Clusters for CPEB1 Gene

Cytoplasmic polyadenylation element binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPEB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB1 Gene

No ASD Table

Relevant External Links for CPEB1 Gene

GeneLoc Exon Structure for
CPEB1
ECgene alternative splicing isoforms for
CPEB1

Expression for CPEB1 Gene

mRNA expression in normal human tissues for CPEB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPEB1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for CPEB1 Gene

This gene is overexpressed in Heart (34.4) and Neutrophil (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CPEB1 Gene



SOURCE GeneReport for Unigene cluster for CPEB1 Gene Hs.547988

mRNA Expression by UniProt/SwissProt for CPEB1 Gene

Q9BZB8-CPEB1_HUMAN
Tissue specificity: Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.
genes like me logo Genes that share expression patterns with CPEB1: view

Protein tissue co-expression partners for CPEB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CPEB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPEB1 35
  • 92.58 (n)
  • 98.03 (a)
-- 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CPEB1 35
  • 94 (n)
  • 95.9 (a)
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cpeb1 35
  • 92.03 (n)
  • 96.04 (a)
Cpeb1 16
Cpeb1 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CPEB1 35
  • 99.47 (n)
  • 99.11 (a)
CPEB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpeb1 35
  • 91.31 (n)
  • 95.32 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves CPEB1 35
  • 80.06 (n)
  • 86.25 (a)
-- 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb1 35
  • 74.81 (n)
  • 83.12 (a)
Str.5854 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.984 35
zebrafish
(Danio rerio)
Actinopterygii cpeb1b 35
  • 68.14 (n)
  • 69.12 (a)
zorba 35
cpeb1a 36
  • 55 (a)
ManyToMany
cpeb1a 36
  • 55 (a)
ManyToMany
cpeb1b 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta orb 37
  • 59 (a)
orb 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-3 37
  • 44 (a)
cpb-3 36
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4588 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CPEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB1 Gene

ENSEMBL:
Gene Tree for CPEB1 (if available)
TreeFam:
Gene Tree for CPEB1 (if available)

Paralogs for CPEB1 Gene

Paralogs for CPEB1 Gene

Pseudogenes.org Pseudogenes for CPEB1 Gene

genes like me logo Genes that share paralogs with CPEB1: view

Variants for CPEB1 Gene

Sequence variations from dbSNP and Humsavar for CPEB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1367841 -- 82,641,874(-) TATAA(C/T)GTGGT intron-variant
rs4297655 -- 82,590,050(+) tTTTG(C/T)TTCTA intron-variant
rs4778686 -- 82,642,084(+) ACTAT(A/G)ATTGA intron-variant
rs4779037 -- 82,628,025(+) aaggg(G/T)tcata intron-variant
rs4779038 -- 82,632,644(+) ccaag(C/T)agctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB1 Gene

Variant ID Type Subtype PubMed ID
nsv428309 CNV Gain 18775914
dgv763e1 CNV Complex 17122850
dgv764e1 CNV Complex 17122850
esv22027 CNV Gain+Loss 19812545
nsv483125 CNV Loss 15286789
nsv833071 CNV Gain 17160897
esv2449307 CNV Deletion 19546169
nsv1640 CNV Insertion 18451855
esv2160515 CNV Deletion 18987734
esv1651554 CNV Deletion 17803354
esv2749956 CNV Deletion 23290073
esv4952 CNV Deletion 18987735
esv2671639 CNV Deletion 23128226
esv2566465 CNV Deletion 19546169
esv5568 CNV Loss 19470904
esv34318 CNV Loss 17911159
esv2749957 CNV Deletion 23290073
esv2674021 CNV Deletion 23128226
nsv817702 CNV Loss 17921354
esv33057 CNV Gain 17666407

Variation tolerance for CPEB1 Gene

Residual Variation Intolerance Score: 39.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.77; 93.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPEB1 Gene

HapMap Linkage Disequilibrium report
CPEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB1 Gene

Disorders for CPEB1 Gene

Relevant External Links for CPEB1

Genetic Association Database (GAD)
CPEB1
Human Genome Epidemiology (HuGE) Navigator
CPEB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPEB1
genes like me logo Genes that share disorders with CPEB1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB1 Gene

Publications for CPEB1 Gene

  1. Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron. (PMID: 19887896) Chae Y.S. … Kaang B.K. (Exp. Mol. Med. 2010) 23 67
  2. Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control. (PMID: 20364142) Novoa I. … Mendez R. (Nat. Cell Biol. 2010) 23 67
  3. Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development. (PMID: 19161537) Hansen C.N. … Norrild B. (APMIS 2009) 23 67
  4. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) HAogele S. … Katschinski D.M. (Biochem. J. 2009) 23 67
  5. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. (PMID: 19254368) Lin A.C. … Holt C.E. (Neural Dev 2009) 23 67

Products for CPEB1 Gene

Sources for CPEB1 Gene

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