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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPE Gene

protein-coding   GIFtS: 72
GCID: GC04P166300

Carboxypeptidase E

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase E1 2     Prohormone-Processing Carboxypeptidase2 3
Carboxypeptidase H1 2 3     CPH2 3
Enkephalin Convertase1 2 3     EC 3.4.17.103 8
Cobalt-Stimulated Chromaffin Granule Carboxypeptidase1 2     EC 3.4.178
Insulin Granule-Associated Carboxypeptidase1 2     

External Ids:    HGNC: 23031   Entrez Gene: 13632   Ensembl: ENSG000001094727   OMIM: 1148555   UniProtKB: P168703   

Export aliases for CPE gene to outside databases

Previous GC identifers: GC04P167151 GC04P166728 GC04P166877 GC04P166657 GC04P166519 GC04P162051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPE Gene:
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the
biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein.
The protein specifically binds regulated secretory pathway proteins, including prohormones, but not
constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CPE Gene: 
CPE (carboxypeptidase E) is a protein-coding gene. Diseases associated with CPE include obesity with impaired prohormone processing, and pulmonary neuroendocrine tumor, and among its related super-pathways are Peptide hormone metabolism and Allograft rejection. GO annotations related to this gene include carboxypeptidase activity and cell adhesion molecule binding. An important paralog of this gene is CPZ.

UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
Function: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone
processing. Processes proinsulin

Gene Wiki entry for CPE (Carboxypeptidase E) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPE gene promoter:
         Pax-5   XBP-1   IRF-1   AP-4   Cdc5   E47   GATA-2   HOXA5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPE promoter sequence
   Search SABiosciences Chromatin IP Primers for CPE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

CPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P166300:  view genomic region     (about GC identifiers)

Start:
166,282,346 bp from pter      End:
166,419,482 bp from pter
Size:
137,137 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870 (See protein sequence)
Recommended Name: Carboxypeptidase E precursor  
Size: 476 amino acids; 53151 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Isoform 2 interacts with HDAC1 and HDAC2
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By
similarity). Secreted (By similarity). Note=Associated with the secretory granule membrane through direct binding
to lipid rafts in intragranular conditions (By similarity)
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=BAG52254.1; Type=Frameshift; Positions=415;
Secondary accessions: A8K4N1 B3KR42 B4DFN4 D3DP33 Q9UIU9
Alternative splicing: 2 isoforms:  P16870-1   P16870-2   

Explore the universe of human proteins at neXtProt for CPE: NX_P16870

Explore proteomics data for CPE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16870

  • 4/19 DME Specific Peptides for CPE (P16870) (see all 19)
     VANYPYD  GDYWRLL  GNMHGNE  IPFVLSA 

    CPE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPE Protein Expression
    REFSEQ proteins: NP_001864.1  
    ENSEMBL proteins: 
     ENSP00000424830   ENSP00000386104   ENSP00000427629   ENSP00000416601   ENSP00000423699  
    Reactome Protein details: P16870
    Human Recombinant Protein Products for CPE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CPE (Carboxypeptidase E/CPE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CPE
    GenScript Custom Purified and Recombinant Proteins Services for CPE
    Novus Biologicals CPE Proteins
    Sino Biological Recombinant Protein for CPE
    Sino Biological Cell Lysate for CPE 
    ProSpec Recombinant Protein for CPE
    Cloud-Clone Corp. Proteins for CPE 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005794Golgi apparatus IDA19166515
    GO:0005886plasma membrane TAS9019408
    GO:0030658transport vesicle membrane IEA--

    CPE for ontologies           About GeneDecksing



    CPE Antibody Products: 
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    R&D Systems Antibodies for CPE (Carboxypeptidase E/CPE)
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    GenScript Custom Superior Antibodies Services for CPE
    Novus Biologicals CPE Antibodies
    Abcam antibodies for CPE
    Cloud-Clone Corp. Antibodies for CPE 
    ThermoFisher Antibodies for CPE
    LSBio Antibodies in human, mouse, rat for CPE 

    Assay Products for CPE: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPE 
    Cloud-Clone Corp. CLIAs for CPE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase E 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14

    Graphical View of Domain Structure for InterPro Entry P16870

    ProtoNet protein and cluster: P16870

    1 Blocks protein domain: IPB000834 Zinc carboxypeptidase A metalloprotease (M14)

    UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
    Similarity: Belongs to the peptidase M14 family


    CPE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPE_HUMAN, P16870
    Function: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone
    processing. Processes proinsulin
    Catalytic activity: Release of C-terminal arginine or lysine residues from polypeptides

         Genatlas biochemistry entry for CPE:
    carboxypeptidase E,metallo carboxypeptidase family,regulated secretory pathway sorting receptor,involved in the
    trimming of paired basic residues at the C terminus of prohormone-derived peptides,mutated in the obese fat mouse

         Enzyme Numbers (IUBMB): EC 3.4.17.101 2 EC 3.4.172

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS9019408
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0042043neurexin family protein binding IPI19166515
    GO:0050839cell adhesion molecule binding IPI19166515
         
    CPE for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cpe):
     adipose tissue  behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  integument  muscle  nervous system  reproductive system 

    CPE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cpetm1Yplo for CPE

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPE 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPE
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPE:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCPE 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CPE

    Clone
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    GenScript: all cDNA clones in your preferred vector: CPE (NM_001873)
    Sino Biological Human cDNA Clone for CPE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPE
    Sirion Biotech Customized lentivirus for stable overexpression of CPE 
                         Customized lentivirus expression plasmids for stable overexpression of CPE 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin Processing
    Peptide hormone metabolism0.39
    Insulin Processing0.39
    2Allograft rejection
    Type I diabetes mellitus0.69
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Arf6 trafficking events
    Arf6 trafficking events
    5Adenylate cyclase-activating neuropeptides
    Adenylate cyclase-activating neuropeptides

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CPE
        Adenylate cyclase-activating neuropeptides


    1 BioSystems Pathway for CPE
        Arf6 trafficking events


    3        Reactome Pathways for CPE
        Insulin Processing
    Metabolism of proteins
    Peptide hormone metabolism


    1         Kegg Pathway  (Kegg details for CPE):
        Type I diabetes mellitus


    CPE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/29 Interacting proteins for CPE (P168701, 2, 3 ENSP000003861044) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63496 I2D: score=5 
    GTF3C1Q127892, 3MINT-63489 I2D: score=5 
    MED31Q9Y3C72, 3MINT-63495 I2D: score=5 
    POLA2Q141812, 3MINT-63490 I2D: score=5 
    POLDIP2Q9Y2S72, 3MINT-63494 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0006464cellular protein modification process NAS2334405
    GO:0006508proteolysis IEA--
    GO:0007218neuropeptide signaling pathway NAS2334405
    GO:0008152metabolic process TAS7663508

    CPE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPE for compounds           About GeneDecksing

    EMD Millipore small molecules for CPE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPE (CBPE)

    2 HMDB Compounds for CPE    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CPE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--12588113 2481446 17016423 17139284 9452465
    Insulin Regular -- 11061-68-0target--17139284 17016423

    10/14 Novoseek inferred chemical compound relationships for CPE gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidylglycine 86.3 8 18411149 (1), 7681630 (1), 7865135 (1), 8402152 (1) (see all 7)
    gemsa 82.1 3 7696431 (2)
    prepro npy 67.2 5 19428990 (2), 19190683 (1)
    proglucagon 54.1 1 9287128 (1)
    c-peptide 46.7 2 9662053 (1)
    lysine 23 2 8600990 (1), 9624159 (1)
    glutamate 22.3 6 8314014 (2), 8864828 (1), 8262314 (1), 7556984 (1) (see all 5)
    forskolin 13.3 2 8051069 (1)
    serine 13.2 2 9572108 (1), 19419578 (1)
    glucose 5.23 3 17957445 (1), 8522057 (1)

    Search CenterWatch for drugs/clinical trials and news about CPE / CBPE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPE gene: 
    NM_001873.2  

    Unigene Cluster for CPE:

    Carboxypeptidase E
    Hs.75360  [show with all ESTs]
    Unigene Representative Sequence: NM_001873
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513982 ENST00000402744(uc003irg.4) ENST00000480404 ENST00000431967
    ENST00000511992

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPE:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCPE 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPE

    Additional mRNA sequence: 

    AK090962.1 AK127165.1 AK290996.1 AK294175.1 BC033866.1 BC053612.1 X51405.1 

    22 DOTS entries:

    DT.92453863  DT.97819616  DT.101984035  DT.100881222  DT.92453871  DT.100764518  DT.121254437  DT.121254414 
    DT.121254436  DT.121254470  DT.92453856  DT.92453870  DT.100881228  DT.121254387  DT.121254441  DT.121254454 
    DT.92453867  DT.95273839  DT.95273844  DT.95273850  DT.97857650  DT.95273838 

    24/786 AceView cDNA sequences (see all 786):

    AW264534 CA397468 AA626597 BU072838 BQ582169 BQ632761 AA846222 BF111134 
    BQ268303 AI492611 AA370044 D57796 CA841752 BM512464 BM505396 AV728533 
    CA844206 BU788971 BQ128170 BM314800 BM857424 AI625285 BM352545 BM690232 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CPE (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                          -     -     -     -                                                                                       
    SP2:              -           -     -     -     -                                                                                       
    SP3:                                      -                                                                                             
    SP4:                                                                                                  -     -                           
    SP5:                          -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for CPE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPE expression in normal human tissues (normalized intensities)      CPE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAAAGA
    CPE Expression
    About this image


    CPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Septum   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             Immature Schwann Cells Peripheral Nerve Domain
             Human Schwann Cells (HSC)   
             spinal/ganglion/dorsal root ganglion   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Normal Human Articular chondrocytes (NHAC)   
             skeleton/cranium   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
             colon ; endothelial cells   

    See CPE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPE

    SOURCE GeneReport for Unigene cluster: Hs.75360

    UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
    Tissue specificity: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level),
    as well as in other tumors, including pheochromocytomas and paragangliomas

        SABiosciences Expression via Pathway-Focused PCR Array including CPE: 
              Obesity in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPE gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpe1 , 5 carboxypeptidase E1, 5 88.66(n)1
    96.64(a)1
      8 (32.30 cM)5
    128761  NM_013494.31  NP_038522.21 
     645925585 
    chicken
    (Gallus gallus)
    Aves CPE1 carboxypeptidase E 82.73(n)
    90.19(a)
      422424  XM_420392.3  XP_420392.3 
    lizard
    (Anolis carolinensis)
    Reptilia CPE6
    CPD6
    Uncharacterized protein
    93(a)
    2(a)
    1 ↔ 1
    possible ortholog
    GL343317.1(161017-177495)
    AAWZ02040490(2155-6752)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88362 Xenopus laevis transcribed sequence with weak similarity more 79.89(n)    CD302212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpe1 carboxypeptidase E 74.08(n)
    82.8(a)
      407979  NM_214810.1  NP_999975.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F01D4.43
    egl-211
    zinc carboxypeptidase3
    Protein EGL-211
    44(a)
    (best of 3)3
    53.06(n)1
    46.21(a)1
      IV(10478817-10481942)3
    1779401  NM_069534.51  NP_501935.11 


    ENSEMBL Gene Tree for CPE (if available)
    TreeFam Gene Tree for CPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPE gene
    CPZ2  CPXM22  AEBP12  CPN12  CPD2  CPM2  CPXM12  
    8 SIMAP similar genes for CPE using alignment to 5 protein entries:     CBPE_HUMAN (see all proteins):
    CPN1    CPXM1    CPXM2    CPD    CPZ    DKFZp666J235
    CPM    AEBP1

    CPE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2582 SNPs in CPE are shown (see all 2582)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360114
    A colorectal cancer sample4--see VAR_0360112 R Q mis40--------
    rs709556241,2
    C--162133047(+) AAAAA-/A/AAAA
            
    GGAAA
    1 -- int11NA 2
    rs1130154061,2
    C--166099286(+) TTGCAAAATG/
            
    AAATA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1387359251,2
    C--166298159(+) CCTGAA/TGAATT 1 -- us2k10--------
    rs1415367131,2
    --166298167(+) ATTCAC/TAGGGG 1 -- us2k10--------
    rs1461819931,2
    C--166298270(+) TTAGGA/GAAACA 1 -- us2k10--------
    rs1868196121,2
    --166298303(+) ACCCCC/TTGCCC 1 -- us2k10--------
    rs1921860951,2
    --166298373(+) ATAAAA/TTTTTT 1 -- us2k10--------
    rs15836451,2
    C,F,A,H--166298451(+) TACATG/ATGCCA 1 -- us2k132Minor allele frequency- A:0.42NS MN EA NA WA CSA 2991
    rs1857667381,2
    --166298756(+) GGCTTC/TCAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPE (166282346 - 166419482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPE:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv822820CNV Loss20364138
    nsv819783CNV Loss19587683
    nsv822819CNV Loss20364138


    Human Gene Mutation Database (HGMD): CPE
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPE
    DNA2.0 Custom Variant and Variant Library Synthesis for CPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114855    OMIM disorders: --

    20/29 diseases for CPE (see all 29):    About MalaCards
    obesity with impaired prohormone processing    pulmonary neuroendocrine tumor    neuroendocrine tumor    insulinoma
    obesity, association with    paraganglioma    autoimmune hepatitis    small cell carcinoma
    gastroenteritis    obesity    alcohol dependence    anorexia nervosa
    diarrhea    pheochromocytoma    pituitary adenoma    hyperglycemia
    choroiditis    alcoholism    diabetes mellitus    adenoma

    2 diseases from the University of Copenhagen DISEASES database for CPE:
    Diarrhea     Insulinoma

    CPE for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for CPE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes autoimmune 54.2 7 19120309 (2), 15804058 (2), 17213576 (2), 19893254 (1)
    insulinoma 42.3 5 9870681 (2), 15163304 (1)
    diabetes mellitus insulin-dependent 28.1 1 8314014 (1)
    obesity 27.6 9 9662053 (2), 16219026 (1), 19419578 (1), 9207799 (1)
    neuroendocrine tumors 22.5 3 15492986 (2)
    aqueous humor 21.1 1 8592153 (1)
    niddm 12 3 9662053 (2), 19893254 (1)
    autoimmunity 9.4 1 9421429 (1)
    cancer lung 0 1 20040394 (1)
    glioma 0 3 1764034 (2)

    Genetic Association Database (GAD): CPE
    Human Genome Epidemiology (HuGE) Navigator: CPE (16 documents)

    Export disorders for CPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPE gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with CPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. (PubMed id 2334405)1, 2, 3, 9 Manser E....Lim L. (1990)
    2. Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis. (PubMed id 17957445)1, 4, 9 Jia E.Z....Ma W.Z. (2008)
    3. Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis. (PubMed id 18080843)1, 4, 9 Jia E.Z....Ma W.Z. (2007)
    4. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. (PubMed id 9662053)1, 2, 9 Utsunomiya N.... Nanjo K. (1998)
    5. Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population. (PubMed id 18501121)1, 4, 9 Wang J....Jia E.Z. (2008)
    6. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. (PubMed id 21285511)1, 2 Lee T.K.... Loh Y.P. (2011)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Severe obesity is associated with novel single nucleo tide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese. (PubMed id 19491387)1, 4 Chen H.H....Pan W.H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1363 HGNC: 2303 AceView: CPE Ensembl:ENSG00000109472 euGenes: HUgn1363
    ECgene: CPE Kegg: 1363 H-InvDB: CPE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPE gene:
    Search GeneIP for patents involving CPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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