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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPE Gene

protein-coding   GIFtS: 68
GCID: GC04P166300

carboxypeptidase E
 Explore 33 diseases affiliated with
CPE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPE    

Aliases
for CPE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase E1 2     EC 3.4.17.103 8
Carboxypeptidase H2 3     Cobalt-Stimulated Chromaffin Granule Carboxypeptidase2
Enkephalin Convertase2 3     Insulin Granule-Associated Carboxypeptidase2
Prohormone-Processing Carboxypeptidase2 3     EC 3.4.178
CPH2 3     

External Ids:    HGNC: 23031   Entrez Gene: 13632   Ensembl: ENSG000001094727   OMIM: 1148555   UniProtKB: P168703   

Export aliases for CPE gene to outside databases

Previous GC identifers: GC04P167151 GC04P166728 GC04P166877 GC04P166657 GC04P166519 GC04P162051


Summaries
for CPE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPE:
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of
peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein
specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted
proteins. Mutations in this gene are implicated in type II diabetes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
Function: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone
processing. Processes proinsulin

Gene Wiki entry for CPE (Carboxypeptidase E)


Genomic Views
for CPE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPE gene promoter:
         Pax-5   XBP-1   IRF-1   AP-4   Cdc5   E47   GATA-2   HOXA5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPE promoter sequence
   Search SABiosciences Chromatin IP Primers for CPE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

CPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P166300:  view genomic region     (about GC identifiers)

Start:
 166,282,346 bp from pter      End:
 166,419,482 bp from pter
Size:
 137,137 bases      Orientation:
 plus strand

Proteins
for CPE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870 (See protein sequence)
Recommended Name: Carboxypeptidase E precursor  
Size: 476 amino acids; 53151 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Isoform 2 interacts with HDAC1 and HDAC2
Subcellular location: Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By
similarity). Secreted (By similarity). Note=Associated with the secretory granule membrane through direct binding to
lipid rafts in intragranular conditions (By similarity)
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=BAG52254.1; Type=Frameshift; Positions=415;
Secondary accessions: A8K4N1 B3KR42 B4DFN4 D3DP33 Q9UIU9
Alternative splicing: 2 isoforms:  P16870-1   P16870-2   

Explore the universe of human proteins at neXtProt for CPE: NX_P16870

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16870

    • 4/19 DME Specific Peptides for CPE (P16870) (see all 19)
     VANYPYD  GDYWRLL  GNMHGNE  IPFVLSA 

    CPE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001864.1  
    ENSEMBL proteins: 
     ENSP00000424830   ENSP00000386104   ENSP00000427629   ENSP00000416601   ENSP00000423699  
    Reactome Protein details: P16870
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CPE (Carboxypeptidase E/CPE)
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    Novus Biologicals CPE Protein
    Sino Biological Recombinant Protein for CPE
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPE

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005794Golgi apparatus IDA19166515
    GO:0005886plasma membrane TAS9019408
    GO:0030141secretory granule TAS--


    CPE for ontologies           About GeneDecksing



    CPE Antibody Products: 
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    Novus Biologicals CPE Antibodies
    Search for Antibodies for CPE at Abcam  
    Uscn Antibodies for CPE
    ThermoFisher Antibodies for CPE

    Assay Products for CPE: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for CPE

    Protein Domains /
    Families
    for CPE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPE for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14

    Graphical View of Domain Structure for InterPro Entry P16870

    ProtoNet protein and cluster: P16870

    1 Blocks protein family: IPB000834 Zinc carboxypeptidase A metalloprotease (M14)

    UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
    Similarity: Belongs to the peptidase M14 family


    Function
    for CPE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
    Function: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone
    processing. Processes proinsulin
    Catalytic activity: Release of C-terminal arginine or lysine residues from polypeptides

         Genatlas biochemistry entry for CPE:
    carboxypeptidase E,metallo carboxypeptidase family,regulated secretory pathway sorting receptor,involved in the
    trimming of paired basic residues at the C terminus of prohormone-derived peptides,mutated in the obese fat mouse

    Enzyme Numbers (IUBMB): EC 3.4.17.101 2 EC 3.4.172

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPE
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPE:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmid: CPE 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPE (see all 7)
    OriGene shRNA RFP: CPE
    OriGene siRNA: CPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CPE

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPE (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CPE (NM_001873)
    Sino Biological Human cDNA Clone for CPE
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPE 

    Cell Line
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    Search LifeMap BioReagents cell lines for CPE

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS9019408
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0042043neurexin family protein binding IPI19166515
    GO:0050839cell adhesion molecule binding IPI19166515


    CPE for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cpetm1Yplo for CPE
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cpe):
     adipose tissue  behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  integument  muscle  nervous system  reproductive system 

    CPE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CPE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Insulin Processing
    		Insulin Processing1.00
    		Peptide hormone metabolism0.39
    2Adenylate cyclase-activating neuropeptides
    		Adenylate cyclase-activating neuropeptides1.00
    3Arf6 trafficking events
    		Arf6 trafficking events1.00
    4Processing of Proinsulin to Insulin
    		Processing of Proinsulin to Insulin1.00
    5Allograft rejection
    		Type I diabetes mellitus0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CPE
        Adenylate cyclase-activating neuropeptides


    1 BioSystems Pathway for CPE 
        Arf6 trafficking events

    4        Reactome Pathways for CPE
        Processing of Proinsulin to Insulin
    Insulin Processing
    Metabolism of proteins
    Peptide hormone metabolism


    1         Kegg Pathway  (Kegg details for CPE):
        Type I diabetes mellitus


    CPE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/29 Interacting proteins for CPE (P168701, 2, 3 ENSP000003861044) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63496 I2D: score=5 
    GTF3C1Q127892, 3MINT-63489 I2D: score=5 
    MED31Q9Y3C72, 3MINT-63495 I2D: score=5 
    POLA2Q141812, 3MINT-63490 I2D: score=5 
    POLDIP2Q9Y2S72, 3MINT-63494 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0006464cellular protein modification process NAS2334405
    GO:0006508proteolysis IEA--
    GO:0007218neuropeptide signaling pathway NAS2334405
    GO:0008152metabolic process TAS7663508


    CPE for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPE for compounds           About GeneDecksing

    EMD Millipore small molecules for CPE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPE

    2 HMDB Compounds for CPE    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CPE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--12588113 2481446 17016423 17139284 9452465
    Insulin recombinant-- 9004-10-8target--17139284 17016423

    10/14 Novoseek chemical compound relationships for CPE gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidylglycine 86.3 8 18411149 (1), 7681630 (1), 7865135 (1), 8402152 (1) (see all 7)
    gemsa 82.1 3 7696431 (2)
    prepro npy 67.2 5 19428990 (2), 19190683 (1)
    proglucagon 54.1 1 9287128 (1)
    c-peptide 46.7 2 9662053 (1)
    lysine 23 2 8600990 (1), 9624159 (1)
    glutamate 22.3 6 8314014 (2), 8864828 (1), 8262314 (1), 7556984 (1) (see all 5)
    forskolin 13.3 2 8051069 (1)
    serine 13.2 2 9572108 (1), 19419578 (1)
    glucose 5.23 3 17957445 (1), 8522057 (1)

    Search CenterWatch for drugs/clinical trials and news about CPE / CBPE 

    Transcripts
    for CPE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPE gene: 
    NM_001873.2  

    Unigene Cluster for CPE:

    Carboxypeptidase E
    Hs.75360  [show with all ESTs]
    Unigene Representative Sequence: NM_001873
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513982 ENST00000402744(uc003irg.4) ENST00000480404 ENST00000431967
    ENST00000511992

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPE
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CPE:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmid: CPE 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPE (see all 7)
    OriGene shRNA RFP: CPE
    OriGene siRNA: CPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPE
    Clone
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    Additional cDNA sequence: 

    AK090962.1 AK127165.1 AK290996.1 AK294175.1 BC033866.1 BC053612.1 X51405.1 

    23 DOTS entries:

    DT.92453863  DT.101984035  DT.97819616  DT.100881222  DT.92453871  DT.100764518  DT.121254437  DT.121254414 
    DT.121254436  DT.121254470  DT.92453856  DT.92453870  DT.100881228  DT.121254385  DT.121254387  DT.121254441 
    DT.121254454  DT.92453867  DT.95273839  DT.95273844  DT.95273850  DT.97857650  DT.95273838 

    24/786 AceView cDNA sequences (see all 786):

    BQ636794 AV749385 BQ632473 CA771044 BM504141 BM875466 BQ549358 BC033866 
    BQ694118 BM505364 BM512464 BM263358 N45521 BQ268131 BE219511 AI915632 
    AA385766 CA867094 BF448835 BQ581498 AI423107 CA844206 AI521167 CD676602 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CPE (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                          -     -     -     -                                                                                       
    SP2:              -           -     -     -     -                                                                                       
    SP3:                                      -                                                                                             
    SP4:                                                                                                  -     -                           
    SP5:                          -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for CPE

    Expression
    for CPE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTACAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CPE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CPE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPE

    SOURCE GeneReport for Unigene cluster: Hs.75360

    UniProtKB/Swiss-Prot: CBPE_HUMAN, P16870
    Tissue specificity: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as
    well as in other tumors, including pheochromocytomas and paragangliomas

        SABiosciences Expression via Pathway-Focused PCR Array including CPE: 
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPE

    Orthologs
    for CPE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPE gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPE1 carboxypeptidase E 82.73(n)
    90.19(a)    		   422424  XM_420392.3  XP_420392.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CPE6
    --
    		 --
    		 93(a)
    47(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343317.1(161017-177384)
    AAWZ02040490(2225-6619)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.88362 Xenopus laevis transcribed sequence with weak similarity more 79.89(n)    CD302212.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cpe1 carboxypeptidase E 74.08(n)
    82.8(a)    		   407979  NM_214810.1  NP_999975.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG46783 carboxypeptidase D 41(a)   15A3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F01D4.43
    egl-211    		 zinc carboxypeptidase3
    Protein EGL-211    		 44(a)
    (best of 3)3
    53.06(n)1
    46.21(a)1    		   IV(10478817-10481942)3
    1779401  NM_069534.51  NP_501935.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SOL16
    		 putative carboxypeptidase D
    		 30(a)
    		 1 → many
    		 1(26966887-26970572)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 zinc carboxypeptidase family protein, putative, ex...
    		 35(a)
    		 1 → many
    		 6(2357309-2364541)


    ENSEMBL Gene Tree for CPE (if available)
    TreeFam Gene Tree for CPE (if available) 

    Paralogs
    for CPE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPE gene
    CPZ2  CPXM22  AEBP12  CPN12  CPD2  CPXM12  CPM2  
    8 SIMAP similar genes for CPE using alignment to 5 protein entries:     CBPE_HUMAN (see all proteins):
    CPN1    CPXM1    CPXM2    CPD    CPZ    DKFZp666J235
    CPM    AEBP1

    CPE for paralogs           About GeneDecksing



    Genomic Variants
    for CPE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CPE
         1 CNV: 59180
    Human Gene Mutation Database (HGMD): CPE
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPE
    DNA2.0 Custom Variant and Variant Library Synthesis for CPE

    Disorders / Diseases
    for CPE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPE for disorders           About GeneDecksing

    OMIM gene information: 114855    OMIM disorders: --

    20/33 diseases for CPE (see all 33):    About MalaCards
    obesity with impaired prohormone processing    dna topoisomerase ii    neuroendocrine tumor    hyperproinsulinemia
    pulmonary neuroendocrine tumor    anorexia nervosa    diabetes mellitus    gastroenteritis
    alcohol dependence    small cell carcinoma    pituitary adenoma    insulinoma
    paraganglioma    obesity    autoimmune hepatitis    obesity, association with
    diarrhea    pheochromocytoma    adenoma    hyperglycemia

    2 diseases from the University of Copenhagen DISEASES database for CPE:
    Diarrhea     Insulinoma

    10/11 Novoseek disease relationships for CPE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes autoimmune 54.2 7 19120309 (2), 15804058 (2), 17213576 (2), 19893254 (1)
    insulinoma 42.3 5 9870681 (2), 15163304 (1)
    diabetes mellitus insulin-dependent 28.1 1 8314014 (1)
    obesity 27.6 9 9662053 (2), 16219026 (1), 19419578 (1), 9207799 (1)
    neuroendocrine tumors 22.5 3 15492986 (2)
    aqueous humor 21.1 1 8592153 (1)
    niddm 12 3 9662053 (2), 19893254 (1)
    autoimmunity 9.4 1 9421429 (1)
    cancer lung 0 1 20040394 (1)
    glioma 0 3 1764034 (2)

    Human Genome Epidemiology (HuGE) Navigator: CPE (16 documents)

    Export disorders for CPE gene to outside databases

    Publications
    for CPE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPE gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with CPE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. (PubMed id 2334405)1, 2, 3, 9 Manser E....Lim L. (1990)
    2. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. (PubMed id 9662053)1, 2, 9 Utsunomiya N.... Nanjo K. (1998)
    3. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. (PubMed id 21285511)1, 2 Lee T.K.... Loh Y.P. (2011)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. (PubMed id 18550819)1, 9 Jeffrey K.D....Johnson J.D. (2008)
    7. Effects of carboxypeptidase E overexpression on insulin mRNA levels, regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA. (PubMed id 12588113)7, 9 Polastri L....Davalli A.M. (2002)
    8. Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord. (PubMed id 9815277)1, 9 Reznik S.E....Fricker L.D. (1998)
    9. Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis. (PubMed id 17957445)1, 9 Jia E.Z....Ma W.Z. (2008)
    10. Processing of procarboxypeptidase E into carboxypeptidase E occurs in secretory vesicles. (PubMed id 7790890)1, 9 Song L. and Fricker L. (1995)

    External Searches for CPE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CPE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1363 HGNC: 2303 AceView: CPE Ensembl:ENSG00000109472 euGenes: HUgn1363
    ECgene: CPE Kegg: 1363 H-InvDB: CPE

    Other Databases showing CPE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPE Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CPE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPE gene:
    Search GeneIP for patents involving CPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CPE gene

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    Advanced Cell Diagnostics
    About This Section

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