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Aliases for CPD Gene

Aliases for CPD Gene

  • Carboxypeptidase D 2 3 5
  • Metallocarboxypeptidase D 2 3 4
  • EC 4 58
  • GP180 3 4
  • EC 3.4.17 58

External Ids for CPD Gene

Previous GeneCards Identifiers for CPD Gene

  • GC17P028459
  • GC17P030612
  • GC17P028851
  • GC17P025730
  • GC17P028705
  • GC17P024916

Summaries for CPD Gene

Entrez Gene Summary for CPD Gene

  • The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPD Gene

CPD (Carboxypeptidase D) is a Protein Coding gene. Diseases associated with CPD include Hepatitis B. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. GO annotations related to this gene include metallocarboxypeptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is CPE.

Gene Wiki entry for CPD Gene

Additional gene information for CPD Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPD Gene

Genomics for CPD Gene

Regulatory Elements for CPD Gene

Enhancers for CPD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H030350 1.1 Ensembl ENCODE 11.7 -27.3 -27326 2.9 BATF RAD21 ZBTB40 RARA FOS RUNX3 CREM IKZF2 ZNF362 SP5 CPD BLMH RNU6-1267P SLC6A4 GC17M030345 GC17P030362 ENSG00000207132
GH17H030363 1.5 FANTOM5 Ensembl ENCODE 8.3 -15.0 -14969 1.1 HDAC1 PKNOX1 BMI1 EGR1 ZNF143 FOS ATF7 ETV6 RUNX3 CREM GOSR1 TEFM ATAD5 CPD BLMH LOC101927093 NSRP1 SSH2 GC17P030363
GH17H030476 1.1 ENCODE 10.9 +98.7 98665 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NF1 GOSR1 ATAD5 SUZ12P1 RNF135 SH3GL1P2 ENSG00000264456 CORO6 CPD LRRC37BP1
GH17H030343 2 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -33.7 -33714 4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 BLMH RNU6-1267P TBC1D29 CPD EFCAB5 NSRP1 GC17M030345 ENSG00000207132 GC17P030362
GH17H030263 0.8 ENCODE 10.4 -114.6 -114594 1.7 FOXA2 KLF1 MAX FEZF1 RAD21 YY1 ZNF664 POLR2A GLI2 OVOL3 BLMH SLC6A4 RNU6-1267P NSRP1 CPD TBC1D29 LRRC37BP1 CORO6 GC17M030249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPD on UCSC Golden Path with GeneCards custom track

Promoters for CPD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092988 895 2801 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Locations for CPD Gene

Genomic Locations for CPD Gene
91,085 bases
Plus strand

Genomic View for CPD Gene

Genes around CPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPD Gene

Proteins for CPD Gene

  • Protein details for CPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase D
    Protein Accession:
    Secondary Accessions:
    • B7Z7T9
    • B7ZAU4
    • F5GZH6
    • O15377
    • Q86SH9
    • Q86XE6

    Protein attributes for CPD Gene

    1380 amino acids
    Molecular mass:
    152931 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPD Gene

    Alternative splice isoforms for CPD Gene


neXtProt entry for CPD Gene

Selected DME Specific Peptides for CPD Gene


Post-translational modifications for CPD Gene

  • Glycosylation at posLast=4040, posLast=4141, isoforms=42, posLast=4343, posLast=4444, isoforms=45, isoforms=172, posLast=217217, posLast=399399, isoforms=2410, isoforms=2429, isoforms=2489, isoforms=2522, posLast=626626, posLast=811811, posLast=855855, isoforms=2867, posLast=879879, posLast=955955, posLast=978978, posLast=10701070, and posLast=11421142
  • Modification sites at PhosphoSitePlus

Other Protein References for CPD Gene

Domains & Families for CPD Gene

Gene Families for CPD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
  • Belongs to the peptidase M14 family.
  • There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPD: view

Function for CPD Gene

Molecular function for CPD Gene

GENATLAS Biochemistry:
carboxypeptidase D,175-180kDa ,regulatory family,highly expressed in placenta,pancreas,hepatoma cells,most cell glycoprotein binding duck hepatitis B virus particles,involved in secretory pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
Releases C-terminal Arg and Lys from polypeptides.

Enzyme Numbers (IUBMB) for CPD Gene

Gene Ontology (GO) - Molecular Function for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA,IBA --
GO:0004185 serine-type carboxypeptidase activity TAS 9064476
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPD: view
genes like me logo Genes that share phenotypes with CPD: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPD Gene

Localization for CPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPD Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPD gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CPD: view

Pathways & Interactions for CPD Gene

genes like me logo Genes that share pathways with CPD: view

Gene Ontology (GO) - Biological Process for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CPD: view

No data available for SIGNOR curated interactions for CPD Gene

Drugs & Compounds for CPD Gene

(29) Drugs for CPD Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2239
Pomalidomide Approved Pharma 138
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents 1173
Zinc Approved Pharma 2359
Guanidinoethylmercaptosuccinic acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with CPD: view

Transcripts for CPD Gene

Unigene Clusters for CPD Gene

Carboxypeptidase D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPD Gene

No ASD Table

Relevant External Links for CPD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPD Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for CPD Gene

This gene is overexpressed in Salivary gland (21.6) and Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPD Gene

Protein tissue co-expression partners for CPD Gene

NURSA nuclear receptor signaling pathways regulating expression of CPD Gene:


SOURCE GeneReport for Unigene cluster for CPD Gene:


mRNA Expression by UniProt/SwissProt for CPD Gene:

Tissue specificity: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.

Evidence on tissue expression from TISSUES for CPD Gene

  • Nervous system(4.8)
  • Liver(4.6)
genes like me logo Genes that share expression patterns with CPD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPD Gene

Orthologs for CPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CPD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPD 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia CPD 33 34
  • 92.52 (n)
(Bos Taurus)
Mammalia CPD 34
  • 92 (a)
(Mus musculus)
Mammalia Cpd 33 16 34
  • 88.26 (n)
(Rattus norvegicus)
Mammalia Cpd 33
  • 87.83 (n)
(Ornithorhynchus anatinus)
Mammalia CPD 34
  • 87 (a)
(Monodelphis domestica)
Mammalia CPD 34
  • 81 (a)
(Gallus gallus)
Aves CPD 33 34
  • 75.04 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730225 33
  • 69.58 (n)
(Danio rerio)
Actinopterygii cpda 33 34
  • 62.68 (n)
cpdb 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta svr 35 33 34
  • 48.74 (n)
CG4678 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002414 33
  • 47.32 (n)
(Caenorhabditis elegans)
Secernentea cpd-2 33 34
  • 53.75 (n)
F59A3.1 35
  • 49 (a)
T27A8.1 35
  • 45 (a)
F01D4.4 35
  • 42 (a)
cpd-1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
Species where no ortholog for CPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPD Gene

Gene Tree for CPD (if available)
Gene Tree for CPD (if available)

Paralogs for CPD Gene

Paralogs for CPD Gene

(3) SIMAP similar genes for CPD Gene using alignment to 4 proteins: Pseudogenes for CPD Gene

genes like me logo Genes that share paralogs with CPD: view

Variants for CPD Gene

Sequence variations from dbSNP and Humsavar for CPD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000039223 -- 30,455,075(+) TTCTT(C/T)TTGTT intron-variant
rs1000081517 -- 30,434,420(+) CCAGT(A/G)AAGGG intron-variant
rs1000139534 -- 30,447,741(+) CCCAG(A/G)GAAAA intron-variant
rs1000149770 -- 30,397,430(+) AGTTC(A/G)AAGAG intron-variant
rs1000241630 -- 30,383,104(+) AGTTA(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPD Gene

Variant ID Type Subtype PubMed ID
nsv515870 CNV gain 19592680
nsv1064611 CNV gain 25217958
esv3554304 CNV deletion 23714750
esv2673490 CNV deletion 23128226

Variation tolerance for CPD Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPD Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPD Gene

Disorders for CPD Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPD Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards
Search CPD in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPD Gene

Publications for CPD Gene

  1. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. (PMID: 9355738) Tan F … Skidgel RA (The Biochemical journal 1997) 2 3 4 22 60
  2. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. (PMID: 12643288) Kalinina EV … Fricker LD (The Journal of biological chemistry 2003) 3 4 22 60
  3. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley DA … Skidgel RA (Genomics 1998) 2 3 22 60
  4. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. (PMID: 9714835) Ishikawa T … Kuroki K (Gene 1998) 3 4 22 60
  5. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. (PMID: 9064476) McGwire GB … Skidgel RA (Life sciences 1997) 3 4 22 60

Products for CPD Gene

Sources for CPD Gene

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