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CPD Gene

protein-coding   GIFtS: 62
GCID: GC17P028705

Carboxypeptidase D

  See CPD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase D1 2
Metallocarboxypeptidase D1 2 3
EC 3.4.17.223 8
GP1802
gp1803
EC 3.4.178

External Ids:    HGNC: 23011   Entrez Gene: 13622   Ensembl: ENSG000001085827   OMIM: 6031025   UniProtKB: O759763   

Export aliases for CPD gene to outside databases

Previous GC identifers: GC17P028459 GC17P030612 GC17P028851 GC17P025730 GC17P024916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPD Gene:
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The
pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has
been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B
virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CPD Gene:
CPD (carboxypeptidase D) is a protein-coding gene. Diseases associated with CPD include hepatitis b, and hepatitis. GO annotations related to this gene include metallocarboxypeptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is CPZ.

Gene Wiki entry for CPD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPD gene promoter:
         CREB   GATA-3   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPD promoter sequence
   Search Chromatin IP Primers for CPD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

CPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPD gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P028705:  view genomic region     (about GC identifiers)

Start:
28,705,923 bp from pter      End:
28,797,007 bp from pter
Size:
91,085 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976 (See protein sequence)
Recommended Name: Carboxypeptidase D precursor  
Size: 1380 amino acids; 152931 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Secondary accessions: B7Z7T9 B7ZAU4 F5GZH6 O15377 Q86SH9 Q86XE6
Alternative splicing: 2 isoforms:  O75976-1   O75976-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPD: NX_O75976

Explore proteomics data for CPD at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr40, Thr41, Thr42, Thr43, Thr44, Ser45, Asn172, Asn217, Asn399, Asn410,
                                 Asn429, Thr489, Asn522, Asn626, Asn811, Asn855, Asn867, Asn879, Asn955, Asn978 (see all 22)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CPD (O75976) (see all 39)
     GLENATI  GDYWRLL  GNMHGNE  LTACIIWC 


    See CPD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186704.1  NP_001295.2  

    ENSEMBL proteins: 
     ENSP00000225719   ENSP00000444443   ENSP00000463763   ENSP00000466049   ENSP00000464255  
    Reactome Protein details: O75976

    CPD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for CPD
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPD

     
    Search eBioscience for Proteins for CPD 

    CPD Antibody Products:

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    Abcam antibodies for CPD
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    LSBio Antibodies in human, mouse, rat for CPD

    CPD Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPD
    Cloud-Clone Corp. CLIAs for CPD
    Search eBioscience for ELISAs for CPD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase D
    Serine-type carboxypeptidases

    4 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14
     IPR015567 Pept_M14B_carboxypept_D2

    Graphical View of Domain Structure for InterPro Entry O75976

    ProtoNet protein and cluster: O75976

    UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976
    Domain: There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic
    activity
    Similarity: Belongs to the peptidase M14 family


    Find genes that share domains with CPD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPD_HUMAN, O75976
    Catalytic activity: Releases C-terminal Arg and Lys from polypeptides
    Biophysicochemical properties: pH dependence: Optimum pH is 6.0-6.5;

         Genatlas biochemistry entry for CPD:
    carboxypeptidase D,175-180kDa ,regulatory family,highly expressed in placenta,pancreas,hepatoma cells,most cell
    glycoprotein binding duck hepatitis B virus particles,involved in secretory pathway

         Enzyme Numbers (IUBMB): EC 3.4.17.221 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0004185serine-type carboxypeptidase activity TAS9064476
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CPD           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CPD:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CPD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPD

    miRNA
    Products:
        
    miRTarBase miRNAs that target CPD:
    hsa-mir-19b-3p (MIRT031284), hsa-mir-320a (MIRT044809), hsa-mir-196a-5p (MIRT026089), hsa-mir-155-5p (MIRT020910)

    Block miRNA regulation of human, mouse, rat CPD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPD (see all 139):
    hsa-miR-124* hsa-miR-579 hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-376a* hsa-miR-508-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCPD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CPD
    Predesigned siRNA for gene silencing in human, mouse, rat CPD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPD

    Clone
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    OriGene clones in human, mouse for CPD (see all 8)
    OriGene ORF clones in mouse, rat for CPD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPD (NM_001304)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPD

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBPD_HUMAN, O75976: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane TAS9064476
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with CPD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPD About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with CPD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CPD
        Golgi Associated Vesicle Biogenesis


        Pathway & Disease-focused RT2 Profiler PCR Array including CPD: 
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CPD (O759763 ENSP000002257194) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CBP621403I2D: score=1 
    LCKENSP000003378254STRING: ENSP00000337825
    UHRF2ENSP000002768934STRING: ENSP00000276893
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    TCF3ENSP000002629654STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with CPD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPD (CBPD)

    1 HMDB Compound for CPD    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CPD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Guanidinoethylmercaptosuccinic acidgemsa (see all 2)77482-44-1target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for CPD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 58.6 1 16190982 (1)
    1,10-phenanthroline 40.8 1 15918796 (1)
    acth 18.2 1 11373325 (1)
    nitric oxide 0 9 11306718 (4), 18535109 (1)



    Find genes that share compounds with CPD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPD gene (2 alternative transcripts): 
    NM_001199775.1  NM_001304.4  

    Unigene Cluster for CPD:

    Carboxypeptidase D
    Hs.446079  [show with all ESTs]
    Unigene Representative Sequence: NM_001304
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225719(uc002hfb.2 uc010wbo.2 uc010wbp.2) ENST00000583275
    ENST00000543464 ENST00000581826 ENST00000584221 ENST00000588977 ENST00000584050
    ENST00000584051 ENST00000579502 ENST00000580396
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CPD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPD (see all 139):
    hsa-miR-124* hsa-miR-579 hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-376a* hsa-miR-508-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCPD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CPD
    Predesigned siRNA for gene silencing in human, mouse, rat CPD
    Clone
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    OriGene clones in human, mouse for CPD (see all 8)
    OriGene ORF clones in mouse, rat for CPD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPD (NM_001304)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPD
    OriGene qSTAR qPCR primer pairs in human, mouse for CPD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPD
      QuantiTect SYBR Green Assays in human, mouse, rat CPD
      QuantiFast Probe-based Assays in human, mouse, rat CPD

    Additional mRNA sequence: 

    AK302497.1 AK302878.1 AK316409.1 AL049339.1 BC020457.1 BC045549.1 BC045624.1 BC051702.1 
    BC054116.1 BX648887.1 D85390.1 U65090.3 U90914.1 

    15 DOTS entries:

    DT.92370719  DT.447770  DT.91936692  DT.100780712  DT.100664113  DT.75182329  DT.86840795  DT.100044504 
    DT.114730  DT.120932053  DT.120932076  DT.433612  DT.454066  DT.91933726  DT.95090892 

    Selected AceView cDNA sequences (see all 373):

    BU195450 AW418840 AI741239 BU169559 N48278 AA709452 T32556 AW004697 
    AI420553 BU739481 AI569607 AW629853 CB306623 BM718958 AA496545 BP351930 
    AA315128 AW243079 BM671703 AI453446 BU632127 R71517 AI300347 D85390 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTGTGCCT
    CPD Expression
    About this image


    CPD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Thalamus
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testis Somatic Cells Primitive Gonad
             Testis Interstitium
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             Thymus
    CPD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446079

    UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976
    Tissue specificity: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal
    muscle, heart and colon carcinoma and melanoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including CPD: 
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CPD
    OriGene qSTAR qPCR primer pairs in human, mouse for CPD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPD
    QuantiTect SYBR Green Assays in human, mouse, rat CPD
    QuantiFast Probe-based Assays in human, mouse, rat CPD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CPD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpd1 , 5 carboxypeptidase D1, 5 88.26(n)1
    91.68(a)1
      11 (46.05 cM)5
    128741  NM_007754.21  NP_031780.21 
     767784245 
    chicken
    (Gallus gallus)
    Aves CPD1 carboxypeptidase D 75.04(n)
    79.86(a)
      417590  XM_004946643.1  XP_004946700.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    many ↔ many
    GL343236.1(1774354-1815170)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL877064.22   -- 76.56(n)    AL877064.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cpda1 carboxypeptidase D, a 62.68(n)
    63.33(a)
      563008  XM_686372.6  XP_691464.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46783
    svr1
    carboxypeptidase D3
    silver1
    44(a)
    (best of 2)3
    48.74(n)1
    40.11(a)1
      15A33
    309981  NM_206596.11  NP_996319.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F59A3.13
    cpd-21
    carboxypeptidase3
    cpd-21
    49(a)
    (best of 3)3
    53.75(n)1
    46.7(a)1
      I(5520395-5529523)3
    1816841  NM_078224.41  NP_510625.21 


    ENSEMBL Gene Tree for CPD (if available)
    TreeFam Gene Tree for CPD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPD gene
    CPZ2  CPE2  CPXM22  AEBP12  CPN12  CPM2  CPXM12  
    3 SIMAP similar genes for CPD using alignment to 4 protein entries:     CBPD_HUMAN (see all proteins):
    CPM    CPE    CPN1

    Find genes that share paralogs with CPD           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CPD
    PGOHUM00000237004 PGOHUM00000244532 PGOHUM00000263036


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPD (see all 1506)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785986631,2
    C,F--28703982(+) ACTCCC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1874888371,2
    --28704057(+) TAATGC/TAGACT 1 -- us2k10--------
    rs1173217801,2
    C,F--28704089(+) AGAGCC/TATTCA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs775827281,2
    C--28704217(+) GTAACT/GTGAAG 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1132626191,2
    C--28704466(+) CTCCAT/CGGCCT 1 -- us2k12Minor allele frequency- C:0.07CSA WA 120
    rs732775371,2
    C,F--28704538(+) CCCTGC/AATGCA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1453585181,2
    C--28704540(+) CTGCAC/TGCAAT 1 -- us2k10--------
    rs1932614741,2
    --28704581(+) CCTGCA/GGCTTT 1 -- us2k10--------
    rs1425920701,2
    --28704633(+) CCATGA/GTTTCT 1 -- us2k10--------
    rs1853747021,2
    --28704857(+) CCTGAA/GATAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPD (28705923 - 28797007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CPD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673490CNV Deletion23128226
    nsv515870CNV Gain19592680
    nsv908044CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPD
    DNA2.0 Custom Variant and Variant Library Synthesis for CPD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603102    OMIM disorders: --

    2 diseases for CPD:    
    About MalaCards
    hepatitis b    hepatitis


    Find genes that share disorders with CPD           About GenesLikeMe

    1 Novoseek inferred disease relationship for CPD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 42.2 9 9714835 (2), 9525948 (2), 9064476 (2), 11602705 (1) (see all 5)


    Export disorders for CPD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CPD gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with CPD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. (PubMed id 9355738)1, 2, 3, 9 Tan F.... Skidgel R.A. (Biochem. J. 1997)
    2. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. (PubMed id 12643288)1, 2, 9 Kalinina E.V. and Fricker L.D. (J. Biol. Chem. 2003)
    3. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. (PubMed id 9714835)1, 2, 9 Ishikawa T....Kuroki K. (Gene 1998)
    4. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. (PubMed id 9064476)1, 2, 9 McGwire G.B.... Skidgel R.A. (Life Sci. 1997)
    5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828)1, 3, 9 Riley D.A....Skidgel R.A. (Genomics 1998)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. (PubMed id 15918796)1, 9 O'Malley P.G....Too C.K. (Biochem. J. 2005)
    9. Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium. (PubMed id 11306718)1, 9 Hadkar V. and Skidgel R.A. (Mol. Pharmacol. 2001)
    10. Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus. (PubMed id 17641957)1, 9 Hoff N.P....Wurthner J.U. (J. Clin. Immunol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1362 HGNC: 2301 AceView: CPD Ensembl:ENSG00000108582 euGenes: HUgn1362
    ECgene: CPD H-InvDB: CPD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CPD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CPD gene:
    Search GeneIP for patents involving CPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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