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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPD Gene

protein-coding   GIFtS: 59
GCID: GC17P028705

carboxypeptidase D
 Explore 14 diseases affiliated with
CPD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPD    

Aliases
for CPD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase D1 2
GP1801 2
Metallocarboxypeptidase D2 3
EC 3.4.17.223 8
Gp1801
EC 3.4.178

External Ids:    HGNC: 23011   Entrez Gene: 13622   Ensembl: ENSG000001085827   OMIM: 6031025   UniProtKB: O759763   

Export aliases for CPD gene to outside databases

Previous GC identifers: GC17P028459 GC17P030612 GC17P028851 GC17P025730 GC17P024916


Summaries
for CPD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPD:
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The
pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been
identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding
protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. (provided by RefSeq,
Jul 2008)

Gene Wiki entry for CPD


Genomic Views
for CPD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPD gene promoter:
         CREB   GATA-3   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPD promoter sequence
   Search SABiosciences Chromatin IP Primers for CPD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

CPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPD gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P028705:  view genomic region     (about GC identifiers)

Start:
 28,705,923 bp from pter      End:
 28,797,007 bp from pter
Size:
 91,085 bases      Orientation:
 plus strand

Proteins
for CPD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976 (See protein sequence)
Recommended Name: Carboxypeptidase D precursor  
Size: 1380 amino acids; 152931 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B7Z7T9 B7ZAU4 F5GZH6 O15377 Q86SH9 Q86XE6
Alternative splicing: 2 isoforms:  O75976-1   O75976-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPD: NX_O75976

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75976

    • 4/39 DME Specific Peptides for CPD (O75976) (see all 39)
     GLENATI  GDYWRLL  GNMHGNE  LTACIIWC 

    CPD Protein expression data from MOPED and PaxDb:    About this image 
    CPD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186704.1  NP_001295.2  

    ENSEMBL proteins: 
     ENSP00000225719   ENSP00000444443   ENSP00000463763   ENSP00000466049   ENSP00000464255  
    Reactome Protein details: O75976
    Human Recombinant Protein Products for CPD: 
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    Uscn Proteins for CPD

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus ----
    GO:0005792microsome ----
    GO:0005802trans-Golgi network ----
    GO:0016020membrane TAS9064476

    CPD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CPD

    Protein Domains /
    Families
    for CPD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPD for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR000834 Peptidase_M14
     IPR015567 Pept_M14B_carboxypept_D2

    Graphical View of Domain Structure for InterPro Entry O75976

    ProtoNet protein and cluster: O75976

    UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976
    Domain: There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity
    Similarity: Belongs to the peptidase M14 family


    Function
    for CPD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPD_HUMAN, O75976
    Catalytic activity: Releases C-terminal Arg and Lys from polypeptides
    Biophysicochemical properties: pH dependence: Optimum pH is 6.0-6.5;

         Genatlas biochemistry entry for CPD:
    carboxypeptidase D,175-180kDa ,regulatory family,highly expressed in placenta,pancreas,hepatoma cells,most cell
    glycoprotein binding duck hepatitis B virus particles,involved in secretory pathway

         Enzyme Numbers (IUBMB): EC 3.4.17.221 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0004185serine-type carboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPD for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CPD:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPD 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CPD
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPD
    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate CPD (see all 139):
    hsa-miR-124* hsa-miR-579 hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-376a* hsa-miR-508-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CPD 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPD (see all 7)
    OriGene shRNA RFP: CPD
    OriGene siRNA: CPD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPD
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPD 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CPD 
    Sirion Biotech Customized adenovirus for potent knockdown of CPD

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPD 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPD


    Pathways & Interactions
    for CPD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		trans-Golgi Network Vesicle Budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for CPD
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    CPD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for CPD (O759763 ENSP000002257194) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CBP621403I2D: score=1 
    LCKENSP000003378254STRING: ENSP00000337825
    UHRF2ENSP000002768934STRING: ENSP00000276893
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    TCF3ENSP000002629654STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0071352cellular response to interleukin-2 ----

    CPD for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPD

    1 HMDB Compound for CPD    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CPD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Guanidinoethylmercaptosuccinic acidgemsa (see all 2)77482-44-1target--17139284 17016423 10592235

    4 Novoseek chemical compound relationships for CPD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 58.6 1 16190982 (1)
    1,10-phenanthroline 40.8 1 15918796 (1)
    acth 18.2 1 11373325 (1)
    nitric oxide 0 9 11306718 (4), 18535109 (1)

    Search CenterWatch for drugs/clinical trials and news about CPD / CBPD 

    Transcripts
    for CPD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPD gene (2 alternative transcripts): 
    NM_001199775.1  NM_001304.4  

    Unigene Cluster for CPD:

    Carboxypeptidase D
    Hs.446079  [show with all ESTs]
    Unigene Representative Sequence: NM_001304
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225719(uc002hfb.2 uc010wbo.2 uc010wbp.2) ENST00000583275
    ENST00000543464 ENST00000581826 ENST00000584221 ENST00000588977 ENST00000584050
    ENST00000584051 ENST00000579502 ENST00000580396

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CPD
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPD
    8/139 QIAGEN miScript miRNA Assays for microRNAs that regulate CPD (see all 139):
    hsa-miR-124* hsa-miR-579 hsa-miR-520f hsa-miR-199a-3p hsa-miR-128 hsa-miR-376a* hsa-miR-508-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CPD 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPD (see all 7)
    OriGene shRNA RFP: CPD
    OriGene siRNA: CPD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPD
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPD 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CPD (NM_001304)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPD 
    Primer
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    Additional cDNA sequence: 

    AK302497.1 AK302878.1 AK316409.1 AL049339.1 BC020457.1 BC045549.1 BC045624.1 BC051702.1 
    BC054116.1 BX648887.1 D85390.1 U65090.3 U90914.1 

    15 DOTS entries:

    DT.92370719  DT.447770  DT.91936692  DT.100780712  DT.100664113  DT.75182329  DT.86840795  DT.114730 
    DT.100044504  DT.120932053  DT.120932076  DT.433612  DT.454066  DT.91933726  DT.95090892 

    24/373 AceView cDNA sequences (see all 373):

    BQ022546 CA449784 AI310982 AW418840 BU739481 AW629853 BM992717 NM_001304 
    BP351930 CB306623 BM682631 CA441758 AU132669 AA315128 CB160037 AI420553 
    BQ009632 CA502812 BE349147 AA866109 BU632127 AA639408 N48278 CB122738 

    GeneLoc Exon Structure


    Expression
    for CPD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTGTGCCT
    CPD Expression
    About this image

    CPD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CPD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPD

    SOURCE GeneReport for Unigene cluster: Hs.446079

    UniProtKB/Swiss-Prot: CBPD_HUMAN, O75976
    Tissue specificity: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle,
    heart and colon carcinoma and melanoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including CPD: 
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPD

    Orthologs
    for CPD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CPD gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPD1 carboxypeptidase D 74.98(n)
    79.52(a)    		   417590  XM_415836.3  XP_415836.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 50(a)
    		 possible ortholog
    		 AAWZ02040490(2225-6619)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL877064.22   -- 76.56(n)    AL877064.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii cpd1 carboxypeptidase D 62.57(n)
    62.98(a)    		   563008  XM_686372.5  XP_691464.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG46783
    svr1    		 carboxypeptidase D3
    silver1    		 44(a)
    (best of 2)3
    48.6(n)1
    40.11(a)1    		   15A33
    309981  NM_166846.41  NP_726675.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea F59A3.13
    cpd-21    		 carboxypeptidase3
    Protein CPD-21    		 49(a)
    (best of 3)3
    53.92(n)1
    47.09(a)1    		   I(5520395-5529523)3
    1816841  NM_078224.31  NP_510625.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SOL16
    		 putative carboxypeptidase D
    		 34(a)
    		 1 → many
    		 1(26966887-26970572)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 zinc carboxypeptidase family protein, putative, ex...
    		 40(a)
    		 1 → many
    		 6(2357309-2364541)


    ENSEMBL Gene Tree for CPD (if available)
    TreeFam Gene Tree for CPD (if available) 

    Paralogs
    for CPD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPD gene
    CPZ2  CPXM22  CPE2  AEBP12  CPN12  CPXM12  CPM2  
    3 SIMAP similar genes for CPD using alignment to 4 protein entries:     CBPD_HUMAN (see all proteins):
    CPM    CPE    CPN1

    CPD for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CPD
    PGOHUM00000237004 PGOHUM00000244532 PGOHUM00000263036


    Genomic Variants
    for CPD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1249 NCBI SNPs in CPD are shown (see all 1249)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs344197291,2
    		C--24981566(+) GTAAC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs785986631,2
    		C,F--28703982(+) ACTCCC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1874888371,2
    		--28704057(+) TAATGC/TAGACT 1 -- us2k10--------
    rs1173217801,2
    		F--28704089(+) AGAGCC/TATTCA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs775827281,2
    		C--28704217(+) GTAACT/GTGAAG 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1132626191,2
    		C--28704466(+) CTCCAT/CGGCCT 1 -- us2k12Minor allele frequency- C:0.07CSA WA 120
    rs732775371,2
    		C--28704538(+) CCCTGC/AATGCA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1453585181,2
    		--28704540(+) CTGCAC/TGCAAT 1 -- us2k10--------
    rs1932614741,2
    		--28704581(+) CCTGCA/GGCTTT 1 -- us2k10--------
    rs1425920701,2
    		--28704633(+) CCATGA/GTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPD (28705923 - 28797007 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CPD
         2 CNVs: 88415 77567

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    Disorders / Diseases
    for CPD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPD for disorders           About GeneDecksing

    OMIM gene information: 603102    OMIM disorders: --

    14 diseases for CPD:    About MalaCards
    hepatitis b    hepatitis    pancreatitis    amblyopia
    herpes simplex    astigmatism    pituitary adenoma    lupus erythematosus
    adenoma    colon carcinoma    hepatocellular carcinoma    breast cancer
    carcinoma    melanoma

    1 Novoseek disease relationship for CPD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 42.2 9 9714835 (2), 9525948 (2), 9064476 (2), 11602705 (1) (see all 5)


    Export disorders for CPD gene to outside databases

    Publications
    for CPD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPD gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CPD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. (PubMed id 9355738)1, 2, 3, 9 Tan F.... Skidgel R.A. (1997)
    2. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. (PubMed id 12643288)1, 2, 9 Kalinina E.V. and Fricker L.D. (2003)
    3. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. (PubMed id 9714835)1, 2, 9 Ishikawa T....Kuroki K. (1998)
    4. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. (PubMed id 9064476)1, 2, 9 McGwire G.B.... Skidgel R.A. (1997)
    5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PubMed id 9628828)1, 3, 9 Riley D.A....Skidgel R.A. (1998)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    8. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. (PubMed id 15918796)1, 9 O'Malley P.G....Too C.K. (2005)
    9. Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium. (PubMed id 11306718)1, 9 Hadkar V. and Skidgel R.A. (2001)
    10. Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus. (PubMed id 17641957)1, 9 Hoff N.P....Wurthner J.U. (2007)

    External Searches for CPD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CPD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1362 HGNC: 2301 AceView: CPD Ensembl:ENSG00000108582 euGenes: HUgn1362
    ECgene: CPD H-InvDB: CPD

    Other Databases showing CPD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CPD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPD gene:
    Search GeneIP for patents involving CPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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