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Aliases for CPD Gene

Aliases for CPD Gene

  • Carboxypeptidase D 2 3
  • Metallocarboxypeptidase D 2 3 4
  • EC 4 64
  • GP180 3 4
  • EC 3.4.17 64

External Ids for CPD Gene

Summaries for CPD Gene

Entrez Gene Summary for CPD Gene

  • The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPD Gene

CPD (Carboxypeptidase D) is a Protein Coding gene. Diseases associated with CPD include hepatitis b and hepatitis. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include metallocarboxypeptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is CPN1.

Gene Wiki entry for CPD Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPD Gene

Genomics for CPD Gene

Genomic Location for CPD Gene

30,378,905 bp from pter
30,469,989 bp from pter
91,085 bases
Plus strand

Genomic View for CPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPD Gene

Regulatory Elements for CPD Gene

Proteins for CPD Gene

  • Protein details for CPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase D
    Protein Accession:
    Secondary Accessions:
    • B7Z7T9
    • B7ZAU4
    • F5GZH6
    • O15377
    • Q86SH9
    • Q86XE6

    Protein attributes for CPD Gene

    1380 amino acids
    Molecular mass:
    152931 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPD Gene


neXtProt entry for CPD Gene

Proteomics data for CPD Gene at MOPED

Post-translational modifications for CPD Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr40, Thr41, Thr42, Thr43, Thr44, Ser45, Asn172, Asn217, Asn399, Asn410, Asn429, Thr489, Asn522, Asn626, Asn811, Asn855, Asn867, Asn879, Asn955, Asn978, Asn1070, and Asn1142

Other Protein References for CPD Gene

Domains for CPD Gene

Gene Families for CPD Gene


  • There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity:
    • O75976
  • Belongs to the peptidase M14 family.:
    • O75976
genes like me logo Genes that share domains with CPD: view

Function for CPD Gene

Molecular function for CPD Gene

GENATLAS Biochemistry: carboxypeptidase D,175-180kDa ,regulatory family,highly expressed in placenta,pancreas,hepatoma cells,most cell glycoprotein binding duck hepatitis B virus particles,involved in secretory pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 6.0-6.5.;
UniProtKB/Swiss-Prot CatalyticActivity: Releases C-terminal Arg and Lys from polypeptides

Enzyme Numbers (IUBMB) for CPD Gene

Gene Ontology (GO) - Molecular Function for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0004185 serine-type carboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPD: view

Phenotypes for CPD Gene

genes like me logo Genes that share phenotypes with CPD: view

miRNA for CPD Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CPD Gene

Localization for CPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPD Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CPD Gene COMPARTMENTS Subcellular localization image for CPD gene
Compartment Confidence
endosome 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CPD: view

Pathways for CPD Gene

genes like me logo Genes that share pathways with CPD: view

Gene Ontology (GO) - Biological Process for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPD: view

Compounds for CPD Gene

(1) HMDB Compounds for CPD Gene

Compound Synonyms Cas Number PubMed IDs
  • Zinc

(2) Drugbank Compounds for CPD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3458-28-4 target
Guanidinoethylmercaptosuccinic acid
  • gemsa
77482-44-1 target

(4) Novoseek inferred chemical compound relationships for CPD Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 58.6 1
1,10-phenanthroline 40.8 1
acth 18.2 1
nitric oxide 0 5
genes like me logo Genes that share compounds with CPD: view

Transcripts for CPD Gene

Unigene Clusters for CPD Gene

Carboxypeptidase D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPD Gene

No ASD Table

Relevant External Links for CPD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPD Gene

mRNA expression in normal human tissues for CPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPD Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPD Gene

SOURCE GeneReport for Unigene cluster for CPD Gene Hs.446079

mRNA Expression by UniProt/SwissProt for CPD Gene

Tissue specificity: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines
genes like me logo Genes that share expressions with CPD: view

Orthologs for CPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CPD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPD 36
  • 99.71 (n)
  • 99.56 (a)
CPD 37
  • 99 (a)
(Bos Taurus)
Mammalia CPD 37
  • 92 (a)
(Canis familiaris)
Mammalia CPD 36
  • 92.52 (n)
  • 95.02 (a)
CPD 37
  • 94 (a)
(Mus musculus)
Mammalia Cpd 36
  • 88.26 (n)
  • 91.68 (a)
Cpd 16
Cpd 37
  • 91 (a)
(Monodelphis domestica)
Mammalia CPD 37
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CPD 37
  • 87 (a)
(Rattus norvegicus)
Mammalia Cpd 36
  • 87.83 (n)
  • 91.62 (a)
(Gallus gallus)
Aves CPD 36
  • 75.04 (n)
  • 79.86 (a)
CPD 37
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730225 36
  • 69.58 (n)
  • 69.73 (a)
(Danio rerio)
Actinopterygii cpda 36
  • 62.68 (n)
  • 63.33 (a)
cpda 37
  • 61 (a)
cpdb 37
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002414 36
  • 47.32 (n)
  • 41.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta svr 36
  • 48.74 (n)
  • 40.11 (a)
svr 37
  • 32 (a)
svr 38
  • 35 (a)
CG4678 38
  • 44 (a)
(Caenorhabditis elegans)
Secernentea cpd-1 37
  • 28 (a)
cpd-2 36
  • 53.75 (n)
  • 46.7 (a)
cpd-2 37
  • 38 (a)
F01D4.4 38
  • 42 (a)
T27A8.1 38
  • 45 (a)
F59A3.1 38
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
Species with no ortholog for CPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPD Gene

Gene Tree for CPD (if available)
Gene Tree for CPD (if available)

Paralogs for CPD Gene

Paralogs for CPD Gene

Selected SIMAP similar genes for CPD Gene using alignment to 4 proteins: Pseudogenes for CPD Gene

genes like me logo Genes that share paralogs with CPD: view

Variants for CPD Gene

Sequence variations from dbSNP and Humsavar for CPD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9406 -- 30,467,002(+) CTTGT(A/G)TTACC utr-variant-3-prime
rs25547 -- 30,425,126(+) GTCTC(-/TT)GCAAT intron-variant
rs717663 -- 30,380,830(+) AGTGT(A/C)TGAAG intron-variant
rs719600 -- 30,404,244(+) aaaaa(A/G)GCTTT intron-variant
rs719601 -- 30,404,397(+) ATGCC(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPD Gene

Variant ID Type Subtype PubMed ID
nsv908044 CNV Gain 21882294
esv2673490 CNV Deletion 23128226
nsv515870 CNV Gain 19592680

Relevant External Links for CPD Gene

HapMap Linkage Disequilibrium report

Disorders for CPD Gene

(2) MalaCards Diseases for CPD Gene

Search for CPD Gene in MalaCards »

(1) Novoseek inferred disease relationships for CPD Gene

Disease -log(P) Hits PubMed IDs
hepatitis b 42.2 8
genes like me logo Genes that share disorders with CPD: view

No data available for UniProtKB/Swiss-Prot for CPD Gene

Publications for CPD Gene

  1. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. (PMID: 9355738) Tan F. … Skidgel R.A. (Biochem. J. 1997) 2 3 4 23
  2. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. (PMID: 12643288) Kalinina E.V. … Fricker L.D. (J. Biol. Chem. 2003) 3 4 23
  3. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley D.A. … Skidgel R.A. (Genomics 1998) 2 3 23
  4. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. (PMID: 9714835) Ishikawa T. … Kuroki K. (Gene 1998) 3 4 23
  5. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. (PMID: 9064476) McGwire G.B. … Skidgel R.A. (Life Sci. 1997) 3 4 23

Products for CPD Gene

Sources for CPD Gene

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