Aliases for CPB2 Gene
External Ids for CPB2 Gene
Previous GeneCards Identifiers for CPB2 Gene
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for CPB2 Gene
CPB2 (Carboxypeptidase B2) is a Protein Coding gene. Diseases associated with CPB2 include Factor Xiii Deficiency and Chronic Thromboembolic Pulmonary Hypertension. Among its related pathways are Collagen chain trimerization and Peptide hormone metabolism. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPB1.
UniProtKB/Swiss-Prot for CPB2 Gene
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.