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Aliases for CPB2 Gene

Aliases for CPB2 Gene

  • Carboxypeptidase B2 (Plasma) 2 3
  • TAFI 3 4 6
  • CPU 3 4 6
  • Carboxypeptidase B2 (Plasma, Carboxypeptidase U) 2 3
  • Thrombin-Activatable Fibrinolysis Inhibitor 2 3
  • Thrombin-Activable Fibrinolysis Inhibitor 3 4
  • Plasma Carboxypeptidase B 2 4
  • Carboxypeptidase U 2 4
  • Carboxypeptidase R 2 3
  • EC 3.4.17.20 4 64
  • PCPB 3 4
  • Carboxypeptidase B-Like Protein 3
  • Carboxypeptidase B2 3
  • EC 3.4.17 64

External Ids for CPB2 Gene

Summaries for CPB2 Gene

Entrez Gene Summary for CPB2 Gene

  • Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for CPB2 Gene

CPB2 (Carboxypeptidase B2 (Plasma)) is a Protein Coding gene. Diseases associated with CPB2 include meningococcal infection and hemophilia b. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPB2 Gene

  • Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Gene Wiki entry for CPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPB2 Gene

Genomics for CPB2 Gene

Genomic Location for CPB2 Gene

Start:
46,053,066 bp from pter
End:
46,121,116 bp from pter
Size:
68,051 bases
Orientation:
Minus strand

Genomic View for CPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPB2 Gene

Regulatory Elements for CPB2 Gene

Proteins for CPB2 Gene

  • Protein details for CPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IY4-CBPB2_HUMAN
    Recommended name:
    Carboxypeptidase B2
    Protein Accession:
    Q96IY4
    Secondary Accessions:
    • A8K464
    • Q15114
    • Q5T9K1
    • Q5T9K2
    • Q9P2Y6

    Protein attributes for CPB2 Gene

    Size:
    423 amino acids
    Molecular mass:
    48424 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPB2 Gene

    Alternative splice isoforms for CPB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPB2 Gene

Proteomics data for CPB2 Gene at MOPED

Post-translational modifications for CPB2 Gene

  • N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn44, Asn73, Asn85, Asn108, and Asn241

Other Protein References for CPB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CPB2 Gene

Gene Families for CPB2 Gene

UniProtKB/Swiss-Prot:

CBPB2_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • Q96IY4
genes like me logo Genes that share domains with CPB2: view

Function for CPB2 Gene

Molecular function for CPB2 Gene

GENATLAS Biochemistry: carboxypeptidase B2,plasma,regulator of plasminogen activation
UniProtKB/Swiss-Prot CatalyticActivity: Release of C-terminal Arg and Lys from a polypeptide.
UniProtKB/Swiss-Prot EnzymeRegulation: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-324.
UniProtKB/Swiss-Prot Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Enzyme Numbers (IUBMB) for CPB2 Gene

Gene Ontology (GO) - Molecular Function for CPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPB2: view
genes like me logo Genes that share phenotypes with CPB2: view

Animal Models for CPB2 Gene

MGI Knock Outs for CPB2:

miRNA for CPB2 Gene

miRTarBase miRNAs that target CPB2

No data available for Transcription Factor Targeting and HOMER Transcription for CPB2 Gene

Localization for CPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPB2 Gene COMPARTMENTS Subcellular localization image for CPB2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CPB2: view

Pathways for CPB2 Gene

genes like me logo Genes that share pathways with CPB2: view

Gene Ontology (GO) - Biological Process for CPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003331 positive regulation of extracellular matrix constituent secretion IEA --
GO:0006508 proteolysis IEA --
GO:0007596 blood coagulation IEA --
GO:0009408 response to heat IEA --
GO:0010757 negative regulation of plasminogen activation IEA --
genes like me logo Genes that share ontologies with CPB2: view

Compounds for CPB2 Gene

(1) HMDB Compounds for CPB2 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(10) Novoseek inferred chemical compound relationships for CPB2 Gene

Compound -log(P) Hits PubMed IDs
hippuryl-l-arginine 93.5 3
hippuryl-l-lysine 91.4 1
lysine 45.2 7
fibrinogen 18.8 2
arginine 18.1 5
genes like me logo Genes that share compounds with CPB2: view

Transcripts for CPB2 Gene

mRNA/cDNA for CPB2 Gene

Unigene Clusters for CPB2 Gene

Carboxypeptidase B2 (plasma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPB2 Gene

No ASD Table

Relevant External Links for CPB2 Gene

GeneLoc Exon Structure for
CPB2
ECgene alternative splicing isoforms for
CPB2

Expression for CPB2 Gene

mRNA expression in normal human tissues for CPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPB2 Gene

This gene is overexpressed in Liver (52.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPB2 Gene

SOURCE GeneReport for Unigene cluster for CPB2 Gene Hs.512937

mRNA Expression by UniProt/SwissProt for CPB2 Gene

Q96IY4-CBPB2_HUMAN
Tissue specificity: Plasma; synthesized in the liver
genes like me logo Genes that share expressions with CPB2: view

Orthologs for CPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPB2 36
  • 99.53 (n)
  • 99.05 (a)
CPB2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPB2 36
  • 85.03 (n)
  • 78.25 (a)
CPB2 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPB2 36
  • 85.42 (n)
  • 80.14 (a)
CPB2 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpb2 36
  • 83.89 (n)
  • 84.36 (a)
Cpb2 16
Cpb2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPB2 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPB2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpb2 36
  • 84.01 (n)
  • 83.37 (a)
chicken
(Gallus gallus)
Aves CPB2 36
  • 65.68 (n)
  • 59.51 (a)
CPB2 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPB2 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpb2 36
  • 61.67 (n)
  • 58.7 (a)
Str.15504 36
zebrafish
(Danio rerio)
Actinopterygii cpb2 36
  • 54.73 (n)
  • 47.84 (a)
cpb2 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3097 38
  • 42 (a)
CG8563 38
  • 34 (a)
CG3108 38
  • 33 (a)
CG18585 38
  • 34 (a)
CG15769 38
  • 26 (a)
CG14820 38
  • 38 (a)
CG18415 38
  • 32 (a)
CG8945 38
  • 30 (a)
CG8562 38
  • 30 (a)
CG2915 38
  • 33 (a)
CG4408 38
  • 34 (a)
CG4017 38
  • 34 (a)
CG7025 38
  • 30 (a)
CG18417 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 36
  • 50.05 (n)
  • 40.3 (a)
R11A5.7 38
  • 31 (a)
Y59C2A.1 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
ManyToMany
CSA.4459 37
  • 35 (a)
ManyToMany
Species with no ortholog for CPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPB2 Gene

ENSEMBL:
Gene Tree for CPB2 (if available)
TreeFam:
Gene Tree for CPB2 (if available)

Paralogs for CPB2 Gene

Paralogs for CPB2 Gene

Selected SIMAP similar genes for CPB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPB2: view

Variants for CPB2 Gene

Sequence variations from dbSNP and Humsavar for CPB2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs927851 -- 46,122,071(-) GGTGG(C/T)ACTCG upstream-variant-2KB
rs1326397 -- 46,107,987(-) TCATT(A/G)CTGTT intron-variant
rs2025734 -- 46,122,469(-) CAAAC(C/T)TGCTT upstream-variant-2KB
rs2025735 -- 46,120,904(-) CTGGG(A/C/G)TAGCC intron-variant
rs2025736 -- 46,120,765(-) TCATG(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPB2 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
dgv1579n71 CNV Gain 21882294
nsv832598 CNV Gain 17160897
dgv1580n71 CNV Gain 21882294
dgv1581n71 CNV Loss 21882294
esv2673081 CNV Deletion 23128226
nsv455876 CNV Gain 19166990
esv1459731 CNV Insertion 17803354
esv2675321 CNV Deletion 23128226
nsv820278 CNV Loss 19587683
dgv1582n71 CNV Loss 21882294
nsv900047 CNV Loss 21882294
nsv900048 CNV Loss 21882294
dgv1583n71 CNV Loss 21882294
dgv1584n71 CNV Loss 21882294
nsv900054 CNV Loss 21882294
esv270613 CNV Insertion 20981092
esv273625 CNV Insertion 20981092
esv1489617 CNV Insertion 17803354
nsv900055 CNV Loss 21882294
nsv900056 CNV Gain 21882294
nsv900057 CNV Loss 21882294
nsv900058 CNV Loss 21882294

Relevant External Links for CPB2 Gene

HapMap Linkage Disequilibrium report
CPB2
Human Gene Mutation Database (HGMD)
CPB2

Disorders for CPB2 Gene

(1) University of Copenhagen DISEASES for CPB2 Gene

(5) Novoseek inferred disease relationships for CPB2 Gene

Disease -log(P) Hits PubMed IDs
thrombosis 42.1 7
hemophilia a 33.7 1
coagulopathy 31.1 2
bleeding 21.1 4
sepsis 0 2

Relevant External Links for CPB2

Genetic Association Database (GAD)
CPB2
Human Genome Epidemiology (HuGE) Navigator
CPB2
genes like me logo Genes that share disorders with CPB2: view

No data available for UniProtKB/Swiss-Prot for CPB2 Gene

Publications for CPB2 Gene

  1. The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13. (PMID: 1427879) Tsai S.P. … Drayna D. (Genomics 1992) 2 3 23
  2. Association of a single nucleotide polymorphism in CPB2 encoding the thrombin-activable fibrinolysis inhibitor (TAF1) with blood pressure. (PMID: 11903334) Koschinsky M.L. … Hegele R.A. (Clin. Genet. 2001) 3 23 49
  3. Thrombin activatable fibrinolysis inhibitor gene polymorphisms are associated with antigenic levels in the Asian-Indian population but may not be a risk for stroke. (PMID: 18986391) Biswas A. … Saxena R. (Br. J. Haematol. 2008) 3 23 49
  4. Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study. (PMID: 19017260) Tregouet D.A. … Morange P.E. (J. Thromb. Haemost. 2009) 3 23 49
  5. Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages. (PMID: 19038242) Matus V. … Mezzano D. (Clin. Chim. Acta 2009) 3 23 49

Products for CPB2 Gene

Sources for CPB2 Gene

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