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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPB2 Gene

protein-coding   GIFtS: 66
GCID: GC13M046627

Carboxypeptidase B2 (Plasma)

(Previous names: carboxypeptidase B2 (plasma, carboxypeptidase U))
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase B2 (Plasma)1 2     Thrombin-Activable Fibrinolysis Inhibitor2 3
CPU2 3 5     EC 3.4.17.203 8
TAFI2 3 5     PCPB2
Carboxypeptidase B2 (Plasma, Carboxypeptidase U)1 2     Carboxypeptidase B-Like Protein2
Carboxypeptidase U1 3     Carboxypeptidase B22
Plasma Carboxypeptidase B1 3     pCPB3
Carboxypeptidase R1 2     EC 3.4.178
Thrombin-Activatable Fibrinolysis Inhibitor1 2     

External Ids:    HGNC: 23001   Entrez Gene: 13612   Ensembl: ENSG000000806187   OMIM: 6031015   UniProtKB: Q96IY43   

Export aliases for CPB2 gene to outside databases

Previous GC identifers: GC13M044627 GC13M040614 GC13M045563 GC13M044425 GC13M045525 GC13M027424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPB2 Gene:
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes
metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are
referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino
residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates.
After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for
this gene and its promoter region. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Jun 2013)

GeneCards Summary for CPB2 Gene: 
CPB2 (carboxypeptidase B2 (plasma)) is a protein-coding gene. Diseases associated with CPB2 include meningococcal infection, and gastroduodenitis, and among its related super-pathways are Complement and Coagulation Cascades and Renin-angiotensin system. GO annotations related to this gene include metallocarboxypeptidase activity and zinc ion binding. An important paralog of this gene is CPO.

UniProtKB/Swiss-Prot: CBPB2_HUMAN, Q96IY4
Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or
anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing
C-terminal lysine residues from fibrin that has already been partially degraded by plasmin

Gene Wiki entry for CPB2 (Carboxypeptidase B2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPB2 gene promoter:
         Sox5   Pbx1a   FOXD1   LUN-1   HNF-1A   C/EBPalpha   AREB6   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.11

CPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPB2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M046627:  view genomic region     (about GC identifiers)

Start:
46,627,321 bp from pter      End:
46,679,211 bp from pter
Size:
51,891 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPB2_HUMAN, Q96IY4 (See protein sequence)
Recommended Name: Carboxypeptidase B2 precursor  
Size: 423 amino acids; 48424 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for CPB2:
3D66 (3D)        3D67 (3D)        3D68 (3D)        3LMS (3D)    
Secondary accessions: A8K464 Q15114 Q5T9K1 Q5T9K2 Q9P2Y6
Alternative splicing: 2 isoforms:  Q96IY4-1   Q96IY4-2   

Explore the universe of human proteins at neXtProt for CPB2: NX_Q96IY4

Explore proteomics data for CPB2 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96IY4

  • 4/9 DME Specific Peptides for CPB2 (Q96IY4) (see all 9)
     PESEPEV  GIKYSFT  HAREWIS  GIHAREW 

    CPB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265470.1  NP_001863.3  

    ENSEMBL proteins: 
     ENSP00000181383   ENSP00000400714  
    Reactome Protein details: Q96IY4
    Human Recombinant Protein Products for CPB2: 
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    Novus Biologicals CPB2 Proteins
    Novus Biologicals CPB2 Lysates
    Sino Biological Recombinant Protein for CPB2
    Sino Biological Cell Lysate for CPB2 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CPB2 for ontologies           About GeneDecksing



    CPB2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase B2 (plasma) 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry Q96IY4

    ProtoNet protein and cluster: Q96IY4

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPB2_HUMAN, Q96IY4
    Similarity: Belongs to the peptidase M14 family


    CPB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPB2_HUMAN, Q96IY4
    Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or
    anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing
    C-terminal lysine residues from fibrin that has already been partially degraded by plasmin
    Catalytic activity: Release of C-terminal Arg and Lys from a polypeptide
    Enzyme regulation: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short
    half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by
    interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and
    in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic
    thrombin-cleavage site present at Arg-324

         Genatlas biochemistry entry for CPB2:
    carboxypeptidase B2,plasma,regulator of plasminogen activation

         Enzyme Numbers (IUBMB): EC 3.4.17.201 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPB2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cpb2):
     growth/size  homeostasis/metabolism  immune system  mortality/aging  renal/urinary system 
     respiratory system  tumorigenesis 

    CPB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CPB2: Cpb2tm1Mng Cpb2tm1Efp Cpb2tm1Nok Cpb2tm1Jcmm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPB2 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CPB2:
    hsa-miR-1323 hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidCPB2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPB2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Renin-angiotensin system
    Metabolism of Angiotensinogen to Angiotensins0.43
    3Insulin Processing
    Peptide hormone metabolism0.39
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CPB2
        Complement and Coagulation Cascades


    3        Reactome Pathways for CPB2
        Metabolism of Angiotensinogen to Angiotensins
    Metabolism of proteins
    Peptide hormone metabolism


    3         Kegg Pathways  (Kegg details for CPB2):
        Complement and coagulation cascades
    Pancreatic secretion
    Protein digestion and absorption


    CPB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CPB2 (Q96IY43 ENSP000001813834) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=2 STRING: ENSP00000308541
    A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
    C5P010313, ENSP000002236424I2D: score=1 STRING: ENSP00000223642
    PLGP007473, ENSP000003089384I2D: score=2 STRING: ENSP00000308938
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007596blood coagulation IEA--
    GO:0009408response to heat IEA--
    GO:0042493response to drug IEA--
    GO:0042730fibrinolysis IEA--

    CPB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPB2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CPB2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPB2 (CBPB2)

    1 HMDB Compound for CPB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    10 Novoseek inferred chemical compound relationships for CPB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hippuryl-l-arginine 93.5 4 10351989 (1), 2328266 (1), 15802136 (1)
    hippuryl-l-lysine 91.4 1 2328266 (1)
    lysine 45.2 8 11292199 (2), 10351989 (1), 10686274 (1), 10759708 (1) (see all 6)
    fibrinogen 18.8 2 15691280 (1), 14697944 (1)
    arginine 18.1 6 15802136 (3), 10759708 (1), 11939578 (1)
    pcbs 16.3 11 9162090 (5), 12162965 (3)
    heparin 10.4 1 12195701 (1)
    cholesterol 0 2 12439147 (1)
    calcium 0 1 9162090 (1)
    creatinine 0 5 12439147 (1), 14697944 (1)

    Search CenterWatch for drugs/clinical trials and news about CPB2 / CBPB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPB2 gene (3 alternative transcripts): 
    NM_001278541.1  NM_001872.4  NM_016413.3  

    Unigene Cluster for CPB2:

    Carboxypeptidase B2 (plasma)
    Hs.512937  [show with all ESTs]
    Unigene Representative Sequence: NM_001872
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000181383(uc001vaw.3 uc001vax.3) ENST00000439329

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CPB2:
    hsa-miR-1323 hsa-miR-548o
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    Additional mRNA sequence: 

    AB011969.1 AK290829.1 BC007057.1 BT006936.1 M75106.1 

    7 DOTS entries:

    DT.452838  DT.91750453  DT.91750451  DT.100785542  DT.91750457  DT.100785543  DT.91873259 

    24/103 AceView cDNA sequences (see all 103):

    AA343872 CR626525 CB157619 CB156851 AU100156 CB154355 AV655223 AV652340 
    BG616950 BG567264 BG568240 AI271641 BG569281 BG617911 CB161453 BG566051 
    BC007057 CB161965 AV651850 AV651233 BG616456 BG565100 T89568 AV662298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPB2 expression in normal human tissues (normalized intensities)      CPB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTTACC
    CPB2 Expression
    About this image


    CPB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             visceral organ   
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Uterus (Reproductive System)
             cervix   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See CPB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPB2

    SOURCE GeneReport for Unigene cluster: Hs.512937

    UniProtKB/Swiss-Prot: CBPB2_HUMAN, Q96IY4
    Tissue specificity: Plasma; synthesized in the liver

        SABiosciences Custom PCR Arrays for CPB2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPB2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpb21 , 5 carboxypeptidase B2 (plasma)1, 5 83.93(n)1
    84.32(a)1
      14 (39.73 cM)5
    563731  NM_019775.31  NP_062749.21 
     752422875 
    chicken
    (Gallus gallus)
    Aves CPB21 carboxypeptidase B2 (plasma) 65.65(n)
    60.51(a)
      418851  XM_417046.3  XP_417046.3 
    lizard
    (Anolis carolinensis)
    Reptilia CPB26
    carboxypeptidase B2 (plasma)
    60(a)
    1 ↔ 1
    1(132089979-132107479)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.155042 Transcribed sequence with weak similarity to protein more 72.1(n)    BX703112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpb21 carboxypeptidase B2 (plasma) 54.49(n)
    47.84(a)
      100000935  NM_001020703.2  NP_001018539.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y59C2A.13
    F02D8.41
    carboxypeptidase3
    Protein F02D8.41
    36(a)
    (best of 2)3
    48.62(n)1
    39.05(a)1
      II(2208118-2212891)3
    1799941  NM_074283.51  NP_506684.31 


    ENSEMBL Gene Tree for CPB2 (if available)
    TreeFam Gene Tree for CPB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPB2 gene
    CPO2  CPA22  CPA12  CPA62  CPB12  CPA32  CPA52  CPA42  
    8 SIMAP similar genes for CPB2 using alignment to 1 protein entry:     CBPB2_HUMAN:
    CPO    CPB1    CPA3    CPA1    CPA4    CPA2
    CPA6    CPA5

    CPB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1069 SNPs in CPB2 are shown (see all 1069)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0222584
    ----see VAR_0222582 I T mis40--------
    rs674028091,2
    C--27429407(+) TGCTG-/AAATAA 1 -- int10--------
    rs178441131,2
    C,F--27437764(-) AACAT-/ATGGAAT 1 -- int12Minor allele frequency- AT:0.29NS 74
    rs1479038131,2
    C--27438469(+) ATCTC-/AAAA  
            
    AAAAA
    1 -- int10--------
    rs345835491,2
    C--27438809(+) AAAAAA/-TTAAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs1510457901,2
    C--27438810(+) AAGTT-/AAAAAA 1 -- int10--------
    rs115749971,2
    C,F--27571081(-) GCGGCA/GTTTTG 1 -- ds50015Minor allele frequency- G:0.01NA 184
    rs1512144931,2
    C--27571115(+) TCCTCC/TGTAGA 1 -- ds50010--------
    rs1403944191,2
    C--27571174(+) CCCTTC/TGTGGA 1 -- ds50010--------
    rs1456164511,2
    C--27571560(+) GGCACA/GAGCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CPB2 (46627321 - 46679211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for CPB2 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv250e201CNV Deletion23290073
    esv2675321CNV Deletion23128226
    esv2673081CNV Deletion23128226
    esv273625CNV Insertion20981092
    esv1459731CNV Insertion17803354
    esv270613CNV Insertion20981092
    esv1489617CNV Insertion17803354
    nsv900054CNV Loss21882294
    dgv1582n71CNV Loss21882294
    nsv900055CNV Loss21882294


    Human Gene Mutation Database (HGMD): CPB2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CPB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603101    OMIM disorders: --

    20/44 diseases for CPB2 (see all 44):    About MalaCards
    meningococcal infection    gastroduodenitis    hemophilia    hemophilia b
    venous thromboembolism    retinal vein occlusion    blood clots    pulmonary embolism
    von willebrand's disease    cerebrovascular accident    antiphospholipid syndrome    thromboembolism
    thrombophilia    thrombocytosis    gestational diabetes    hyperthyroidism
    disseminated intravascular coagulation    cerebral infarction    thrombosis    behcet's disease

    1 disease from the University of Copenhagen DISEASES database for CPB2:
    Disseminated intravascular coagulation

    CPB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    5 Novoseek inferred disease relationships for CPB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 42.1 8 19195685 (2), 17127436 (1), 19719827 (1), 12958609 (1) (see all 6)
    hemophilia a 33.7 1 15719893 (1)
    coagulopathy 31.1 2 11328287 (1), 15719893 (1)
    bleeding 21.1 4 19719827 (1), 10759708 (1), 15719893 (1), 19038242 (1)
    sepsis 0 2 19719827 (1), 14717966 (1)

    Genetic Association Database (GAD): CPB2
    Human Genome Epidemiology (HuGE) Navigator: CPB2 (36 documents)

    Export disorders for CPB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPB2 gene, integrated from 9 sources (see all 245):
    (articles sorted by number of sources associating them with CPB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma. (PubMed id 1939207)1, 2, 3 Eaton D.L.... Drayna D. (1991)
    2. Association of a single nucleotide polymorphism in CPB2 encoding the thrombin-activable fibrinolysis inhibitor (TAF1) with blood pressure. (PubMed id 11903334)1, 4, 9 Koschinsky M.L....Hegele R.A. (2001)
    3. Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages. (PubMed id 19038242)1, 4, 9 Matus V....Mezzano D. (2009)
    4. [Study on the association of thrombin activatable fibrinolysis inhibitor and the Thr325Ile and Thr147Ala polymorphisms of its encoding gene CPB2 in patients with coronary heart disease] (PubMed id 18683146)1, 4, 9 Xu C.W....Jiang C.Y. (2008)
    5. Thrombin-activatable fibrinolysis inhibitor genetic p olymorphisms as markers of the type of acute coronary syndrome. (PubMed id 19699511)1, 4, 9 TA ssies D....Reverter J.C. (2009)
    6. The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13. (PubMed id 1427879)1, 3, 9 Tsai S.P. and Drayna D. (1992)
    7. Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study. (PubMed id 19017260)1, 4, 9 Tregouet D.A....Morange P.E. (2009)
    8. Thrombin activatable fibrinolysis inhibitor gene polymorphisms are associated with antigenic levels in the Asian-Indian population but may not be a risk for stroke. (PubMed id 18986391)1, 4, 9 Biswas A....Saxena R. (2008)
    9. +1040 C/T polymorphism in coding region of thrombin-a ctivatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fet al loss. (PubMed id 20729722)1, 4 Pruner I....Radojkovic D. (2010)
    10. [Prognosis value of thrombin activatable fibrinolysis inhibitor concentration and C1040T polymorphism in acute myocardial infarction treated with fibrinolysis.]. (PubMed id 20627371)1, 4 GonzA!lez F.J....Benlloch S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1361 HGNC: 2300 AceView: CPB2 Ensembl:ENSG00000080618 euGenes: HUgn1361
    ECgene: CPB2 Kegg: 1361 H-InvDB: CPB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPB2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cpb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPB2 gene:
    Search GeneIP for patents involving CPB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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